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Focus on Pharmacology

Prehospital Intranasal Glucagon for Hypoglycemia

ORCID Icon, , , , ORCID Icon, & show all
Pages 356-359 | Received 20 Dec 2021, Accepted 18 Feb 2022, Published online: 02 Mar 2022

References

  • Centers for Disease Control and Prevention. National Diabetes Statistics Report, 2020. Atlanta, GA: Centers for Disease Control and Prevention. U.S. Dept of Health and Human Services; 2020. https://www.cdc.gov/diabetes/data/statistics-report/index.html
  • Benoit SR, Kahn HS, Geller AI, Budnitz DS, Mann NC, Dai M, Gregg EW, Geiss LS. Diabetes-related emergency medical service activations in 23 states, United States 2015. Prehosp Emerg Care. 2018;22(6):705–12. doi:10.1080/10903127.2018.1456582.
  • Rostykus P, Kennel J, Adair K, Fillinger M, Palmberg R, Quinn A, Ripley J, Daya M. Variability in the treatment of prehospital hypoglycemia: a structured review of EMS protocols in the United States. Preh Emerg Care. 2016;20(4):524–30. doi:10.3109/10903127.2015.1128031.
  • Vukmir RB, Paris PM, Yealy DM. Glucagon: prehospital therapy for hypoglycemia. Ann Emerg Med. 1991;20(4):375–9. doi:10.1016/S0196-0644(05)81658-0.
  • Howell MA, Guly HR. A comparison of glucagon and glucose in the prehospital hypoglycaemia. J Accid Emerg Med. 1997;14(1):30–2. doi:10.1136/emj.14.1.30.
  • Carstens S, Sprehn M. Prehospital treatment of severe hypoglycemia: a comparison of intramuscular glucagon and intravenous dextrose. Prehosp Disaster Med. 1998;13(2-4):44–50. doi:10.1017/S1049023X00030132.
  • Alhazmi R, Parker RD, Wen S. Needlestick injuries among emergency medical services providers in urban and rural areas. J Community Health. 2018;43(3):518–23. doi:10.1007/s10900-017-0446-0.
  • Corrigan M, Wilson SS, Hampton J. Safety and efficacy of intranasally administered medications in the emergency department and prehospital settings. Am J Health Syst Pharm. 2015;72(18):1544–54. doi:10.2146/ajhp140630.
  • Pontiroli AE, Alberetto M, Pozza G. Intranasal glucagon raises blood glucose concentrations in healthy volunteers. Br Med J (Clin Res Ed)). 1983;287(6390):462–3. doi:10.1136/bmj.287.6390.462-a.
  • Freychet L, Rizkalla SW, Desplanque N, Basdevant A, Zirinis P, Tchobroutsky G, Slama G. Effect of intranasal glucagon on blood glucose levels in healthy subjects and hypoglycemic patients with insulin-dependent diabetes. Lancet. 1988;1(8599):1364–6. doi:10.1016/S0140-6736(88)92181-2.
  • Pontiroli AE, Calderara A, Pajetta E, Alberetto M, Pozza G. Intranasal glucagon as remedy for hypoglycemia. Studies in healthy subjects and type I diabetic patients. Diabetes Care. 1989;12(9):604–8. doi:10.2337/diacare.12.9.604.
  • Slama G, Alamowitch C, Desplanque N, Letanoux M, Zirinis P. A new non-invasive method for treating insulin-reaction: intranasal lyophylized glucagon. Diabetologia. 1990;33(11):671–4. doi:10.1007/BF00400568.
  • Rosenfalck AM, Bendtson I, Jørgensen S, Binder C. Nasal glucagon in the treatment of hypoglycemia in type 1 (insulin dependent) diabetic patients. Diabetes Res Clin Pract. 1992;17(1):43–50. doi:10.1016/0168-8227(92)90042-P.
  • Stenninger E, Aman J. Intranasal glucagon treatment relieves hypoglycaemia in children with type 1 (insulin-dependent) diabetes mellitus. Diabetologia. 1993;36(10):931–5. doi:10.1007/BF02374475.
  • Hvidberg A, Djurup R, Hilsted J. Glucose recovery after intranasal glucagon during hypoglycaemia in man. Eur J Clin Pharmacol. 1994;46(1):15–7. doi:10.1007/BF00195909.
  • Sibley T, Jacobsen R, Salomone J. Successful administration of intranasal glucagon in the out-of-hospital environment. Prehosp Emerg Care. 2013;17(1):98–102. doi:10.3109/10903127.2012.717171.
  • Leiss JK, Ratcliffe JM, Lyden JT, Sousa S, Orelien JG, Boal WL, Jagger J. Blood exposure among paramedics: incidence rates from the national study to prevent blood exposure in paramedics. Ann Epidemiol. 2006;16(9):720–5. doi:10.1016/j.annepidem.2005.12.007.
  • Reichard AA, Marsh SM, Tonozzi TR, Konda S, Gormley MA. Occupational injuries and exposures among emergency medical services workers. Prehosp Emerg Care. 2017;21(4):420–31. doi:10.1080/10903127.2016.1274350.
  • Deeb LC, Dulude H, Guzman CB, Zhang S, Reiner BJ, Piché CA, Pradhan S, Zhang XM. A phase 3 multicenter, open-label, prospective study designed to evaluate the effectiveness and ease of use of nasal glucagon in the treatment of moderate and severe hypoglycemia in children and adolescents with type 1 diabetes in the home or school setting. Pediatr Diabetes. 2018;19(5):1007–13. doi:10.1111/pedi.12668.
  • Seaquist ER, Dulude H, Zhang XM, Rabasa-Lhoret R, Tsoukas GM, Conway JR, Weisnagel SJ, Gerety G, Woo VC, Zhang S, et al. Prospective study evaluating the use of nasal glucagon for the treatment of moderate to severe hypoglycaemia in adults with type 1 diabetes in a real-world setting. Diabetes Obes Metab. 2018;20(5):1316–20. doi:10.1111/dom.13278.

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