The effect of apigenin on cyclophosphamide and doxorubicin genotoxicity in vitro and in vivo

References

• Blaszkowsky , L. S. and Erlichman , C. 2006 . “ Carcinogenesis of anticancer drugs ” . In Cancer chemotherapy and biotherapy: principles and practice , Edited by: Chabner , B. A. and Longo , D. L. 70 – 90 . Philadelphia : Lippincott Williams & Wilkins .
   Google Scholar
• Keizer , H. G. , Pinedo , H. M. , Schuurhuis , G. J. and Joenje , H. 1990 . Doxorubicin (adriamycin): A critical review of free radical-dependent mechanisms of cytotoxicity . Pharmacol. Ther. , 47 ( 2 ) : 219 – 231 .
   PubMed Web of Science ®Google Scholar
• Smith , J. J. , Tully , P. and Padberg , R. M. 2005 . Chemoprevention: A primary cancer prevention strategy . Seminars in Oncology Nursing , 21 ( 4 ) : 243 – 251 .
   PubMedGoogle Scholar
• Aydemir , N. , Çelikler , S. and Bilaloðlu , R. 2005 . In vitro genotoxic effects of the anticancer drug gemcitabine in human lymphocytes . Muta. Res. Genetic Toxicol. Environ. Mutagen. , 582 ( 1–2 ) : 35 – 41 .
   Web of Science ®Google Scholar
• Nafisi , S. , Hashemi , M. , Rajabi , M. and Tajmir-Riahi , H. A. 2008 . DNA adducts with antioxidant flavonoids: Morin, apigenin, and naringin . DNA Cell Biol. , 27 ( 8 ) : 433 – 442 .
   PubMed Web of Science ®Google Scholar
• Uhl , M. , Ecker , S. , Kassie , F. , Lhoste , E. , Chakraborty , A. , Mohn , G. and Knasmuller , S. 2003 . Effect of chrysin, a flavonoid compound, on the mutagenic activity of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and benzo(a)pyrene (B(a)P) in bacterial and human hepatoma (Hep G2) cells . Arch. Toxicol. , 77 ( 8 ) : 477 – 484 .
   PubMed Web of Science ®Google Scholar
• Wang , I.-K. , Lin-Shiau , S.-Y. and Lin , J.-K. 1999 . Induction of apoptosis by apigenin and related flavonoids through cytochrome c release and activation of caspase-9 and caspase-3 in leukaemia HL-60 cells . Eur. J. Cancer , 35 ( 10 ) : 1517 – 1525 .
   PubMed Web of Science ®Google Scholar
• Ujiki , M. B. , Ding , X.-Z. , Salabat , M. R. , Bentrem , D. J. , Golkar , L. , Milam , B. , Talamonti , M. S. , Bell , R.H. Jr. , Iwamura , T. and Adrian , T. E. 2006 . Apigenin inhibits pancreatic cancer cell proliferation through G2/M cell cycle arrest . Mol. Cancer , 5 : 76
   PubMed Web of Science ®Google Scholar
• Hertog , M. G.L. , Hollman , P. C.H. , Katan , M. B. and Kromhout , D. 1993 . Intake of potentially anticarcinogenic flavonoids and their determinants in adults in The Netherlands . Nutr. Cancer , 20 ( 1 ) : 21 – 29 .
   PubMed Web of Science ®Google Scholar
• Pietta , P. , Gardana , C. and Pietta , A. 2003 . “ Flavonoids in herbs ” . In Flavonoids in health and disease , Edited by: Rice-Evans , C. A. and Packer , L. 43 – 70 . New York : Marcel Dekker .
   Google Scholar
• Soobrattee , M. A. , Neergheen , V. S. , Luximon-Ramma , A. , Aruoma , O. I. and Bahorun , T. 2005 . Phenolics as potential antioxidant therapeutic agents: Mechanism and actions . Mut. Res. , 579 ( 1–2 ) : 200 – 213 .
   PubMed Web of Science ®Google Scholar
• Siddique , Y. H. and Afzal , M. 2009 . Protective effect of apigenin against hydrogen peroxide induced genotoxic damage on cultured human peripheral blood . J. Appl. Biomed. , 7 ( 1 ) : 35 – 43 .
   Web of Science ®Google Scholar
• Rithidech , K. N. , Tungjai , M. and Whorton , E. B. 2005 . Protective effect of apigenin on radiation-induced chromosomal damage in human lymphocytes . Mut. Res. , 585 ( 1–2 ) : 96 – 104 .
   PubMed Web of Science ®Google Scholar
• Jeyabal , P. V.S. , Syed , M. B. , Venkataraman , M. , Sambandham , J. K. and Sakthisekaran , D. 2005 . Apigenin inhibits oxidative stress-induced macromolecular damage in N-nitrosodiethylamine (NDEA)-induced hepatocellular carcinogenesis in Wistar albino rats . Molec. Carcin. , 44 ( 1 ) : 11 – 20 .
   PubMed Web of Science ®Google Scholar
• Khan , T. H. , Jahangir , T. , Prasad , L. and Sarwat , S. 2006 . Inhibitory effect of apigenin on benzo(a) pyrene-mediated genotoxicity in Swiss albino mice . J. Pharm. Pharmacol. , 58 ( 12 ) : 1655 – 1660 .
   PubMed Web of Science ®Google Scholar
• Gajski , G. and Garaj Vrhovac , V. 2010 . Increased frequency of sister chromatid exchanges and decrease in cell viability and proliferation kinetics in human peripheral blood lymphocytes after in vitro exposure to whole bee venom . J. Environ. Sci. Health A , 45 ( 12 ) : 1654 – 1659 .
   Web of Science ®Google Scholar
• Birt , D. F. , Walker , B. , Tibbels , M. G. and Bresnick , E. 1986 . Anti-mutagenesis and anti-promotion by apigenin, robinetin and indole-3-carbinol . Carcinogenesis , 7 ( 6 ) : 959 – 963 .
   PubMed Web of Science ®Google Scholar
• Choi , J. S. , Park , K. Y. , Moon , S. H. , Rhee , S. H. and Young , H. S. 1994 . Antimutagenic effect of plant flavonoids in the Salmonella assay system . Arch. Pharm. Res. , 17 ( 2 ) : 71 – 75 .
   PubMedGoogle Scholar
• Nagasugi , T. , Nakashima , M. and Komai , K. 2000 . Antimutagens in gaiyou (Artemisia argyi levl. et vant.). . J. Agric. Food Chem. , 48 ( 8 ) : 3256 – 3266 .
   PubMed Web of Science ®Google Scholar
• Balasubramanian , S. and Eckert , R. L. 2007 . Keratinocyte proliferation, differentiation, and apoptosis-Differential mechanisms of regulation by curcumin, EGCG and apigenin . Toxicol. Appl. Pharmacol. , 224 ( 3 ) : 214 – 219 .
   PubMed Web of Science ®Google Scholar
• Torkin , R. , Lavoie , J.-F. , Kaplan , D. R. and Yeger , H. 2005 . Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma . Molec. Cancer Ther. , 4 ( 1 ) : 1 – 11 .
   PubMed Web of Science ®Google Scholar
• Maron , D. M. and Ames , B. N. 1983 . Revised methods for the Salmonella mutagenicity test . Mut. Res. , 113 ( 3–4 ) : 173 – 215 .
   PubMed Web of Science ®Google Scholar
• Musatov , S. A. , Anisimov , V. N. , André , V. , Vigreux , C. , Godard , T. , Gauduchon , P. and Sichel , F. 1998 . Modulatory effects of melatonin on genotoxic response of reference mutagens in the Ames test and comet assay . Mut. Res. , 417 ( 2–3 ) : 75 – 84 .
   PubMed Web of Science ®Google Scholar
• Morita , T. , Asano , N. , Awogi , T. , Sasaki , Y. F. , Sato , S. I. , Shimada , H. , Sutou , S. , Suzuki , T. , Wakata , A. , Sofuni , T. and Hayashi , M. 1997 . Evaluation of the rodent micronucleus assay in the screening of IARC carcinogens (Groups 1, 2A and 2B): The summary report of the 6th collaborative study by CSGMT/JEMS MMS. Collaborative Study of the Micronucleus Group Test . Mammalian Mutagenicity Study Group. Mut. Res. , 389 ( 1 ) : 3 – 122 .
   PubMed Web of Science ®Google Scholar
• Hayashi , M. , Morita , T. , Kodama , Y. , Sofuni , T. and Ishidate , M. Jr. 1990 . The micronucleus assay with mouse peripheral blood reticulocytes using acridine orange-coated slides . Mut. Res. , 245 ( 4 ) : 245 – 249 .
   PubMed Web of Science ®Google Scholar
• Noel , S. , Kasinathan , M. and Rath , S. K. 2006 . Evaluation of apigenin using in vitro cytochalasin blocked micronucleus assay . Toxicol. in Vitro , 20 ( 7 ) : 1168 – 1172 .
   PubMed Web of Science ®Google Scholar
• Garaj Vrhovac , V. , Orešèanin , V. , Ruk , D. and Gajski , G. 2009 . In vitro assessment of genotoxic effects of electric arc furnace dust on human lymphocytes using the alkaline comet assay . J. Environ. Sci. Health A. , 44 ( 3 ) : 279 – 87 .
   Google Scholar
• Nijveldt , R. J. , Van Nood , E. , Van Hoorn , D. E.C. , Boelens , P. G. , Van Norren , K. and Van Leeuwen , P. A.M. 2001 . Flavonoids: A review of probable mechanisms of action and potential applications . Am. J. Clin. Nutr. , 74 ( 4 ) : 418 – 425 .
   PubMed Web of Science ®Google Scholar
• Nagao , M. , Morita , N. , Yahagi , T. , Shimizu , M. , Kuroyanagi , M. , Fukuoka , M. , Yoshihira , K. , Matori , S. , Fujino , T. and Sugimura , T. 1981 . Mutagenicities of 61 flavonoids and 11 related compounds . Environ. Mut. , 3 ( 4 ) : 401 – 420 .
   PubMedGoogle Scholar
• Czeczot , H. , Tudek , B. , Kusztelak , J. , Szymczyk , T. , Dobrowolska , B. , Glinkowska , G. , Malinowski , J. and Strzelecka , H. 1990 . Isolation and studies of the mutagenic activity in the Ames test of flavonoids naturally occurring in medical herbs . Mut. Res. , 240 ( 3 ) : 209 – 216 .
   PubMed Web of Science ®Google Scholar
• Cutts , S. M. , Nudelman , A. , Rephaeli , A. and Phillips , D. R. 2005 . The power and potential of doxorubicin-DNA adducts . IUBMB Life , 57 ( 2 ) : 73 – 81 .
   PubMed Web of Science ®Google Scholar
• Webb , M. R. and Ebeler , S. E. 2004 . Comparative analysis of topoisomerase IB inhibition and DNA intercalation by flavonoids and similar compounds: structural determinates of activity . Biochem. J. , 384 ( Pt 3 ) : 527 – 541 .
   PubMed Web of Science ®Google Scholar
• Kanakis , C. D. , Nafisi , S. and Rajabi , M. 2009 . Structural analysis of DNA and RNA interactions with antioxidant flavonoids . Spectroscopy , 23 ( 1 ) : 29 – 43 .
   Web of Science ®Google Scholar
• Snyder , R. D. and Gillies , P. J. 2002 . Evaluation of the clastogenic, DNA intercalative, and topoisomerase II-interactive properties of bioflavonoids in Chinese hamster V79 cells . Environ. Molec. Mut , 40 ( 4 ) : 266 – 276 .
   PubMed Web of Science ®Google Scholar
• Wan , L. , Guo , C. , Yu , Q. , Li , Y. , Wang , X. , Wang , X. and Chen , C. 2007 . Quantitative determination of apigenin and its metabolism in rat plasma after intravenous bolus administration by HPLC coupled with tandem mass spectrometry . J. Chromatogr. B. , 855 ( 2 ) : 286 – 289 .
   PubMed Web of Science ®Google Scholar
• Samy , R. P. , Gopalakrishnakone , P. and Ignacimuthu , S. 2006 . Anti-tumor promoting potential of luteolin against 7,12-dimethylbenz(a)anthracene-induced mammary tumors in rats . Chem. Biol. Interact. , 164 ( 1–2 ) : 1 – 14 .
   PubMed Web of Science ®Google Scholar
• Fleming , R. A. 1997 . An overview of cyclophosphamide and ifosfamide pharmacology . Pharmacotherapy. , 17 ( 5 Pt 2 ) : 146S – 154S .
   PubMed Web of Science ®Google Scholar
• Sharma , N. , Trikha , P. , Athar , M. and Raisuddin , S. 2001 . Inhibition of benzo[a]pyrene- and cyclophoshamide induced mutagenicity by Cinnamomum cassia . Mut. Res. , 480–481 : 179 – 88 .
   PubMed Web of Science ®Google Scholar
• Chen , Y. , Jia , X. , Chen , J. , Wang , J. and Hu , M. 2010 . The pharmacokinetics of raloxifene and its interaction with apigenin in rat . Molecules. , 15 ( 11 ) : 8478 – 8487 .
   PubMed Web of Science ®Google Scholar
• Psotová , J. , Chlopčíkova , Š. , Miketová , P. , Hrbác , J. and Šimánek , V. 2004 . Chemoprotective effect of plant phenolics against anthracycline-induced toxicity on rat cardiomyocytes. Part III. Apigenin, baicalelin, kaempherol, luteolin and quercetin . Phytother. Res. , 18 ( 7 ) : 516 – 521 .
   PubMed Web of Science ®Google Scholar
• Navarro , J. , Obrador , E. , Carretero , J. , Petschen , I. , Aviñó , J. , Perez , P. and Estrela , J. M. 1999 . Changes in glutathione status and the antioxidant system in blood and in cancer cells associate with tumour growth in vivo . Free Rad. Biol. Med. , 26 ( 3–4 ) : 410 – 418 .
   PubMed Web of Science ®Google Scholar
• Thomasset , S. C. , Berry , D. P. , Garcea , G. , Marczylo , T. , Steward , W. P. and Gescher , A. J. 2007 . Dietary polyphenolic phytochemicals - Promising cancer chemopreventive agents in humans? A review of their clinical properties . Int. J. Cancer , 120 ( 3 ) : 451 – 458 .
   PubMed Web of Science ®Google Scholar
• Subapriya , R. , Kumaraguruparan , R. , Abraham , S. K. and Nagini , S. 2004 . Protective effects of ethanolic neem leaf extract on N-methyl-N′ -nitro-N-nitrosoguanidine-induced genotoxicity and oxidative stress in mice . Drug Chem. Toxicol. , 27 ( 1 ) : 15 – 26 .
   PubMed Web of Science ®Google Scholar
• Kumaraguruparan , R. , Chandra Mohan , K. V.P. , Abraham , S. K. and Nagini , S. 2005 . Attenuation of N-methyl-N′-nitro-N-nitrosoguanidine induced genotoxicity and oxidative stress by tomato and garlic combination . Life Sci. , 76 ( 19 ) : 2247 – 2255 .
   PubMed Web of Science ®Google Scholar
• Larramendy , M. L. , Bianchi , M. S. and Padron , J. 1989 . Correlation between the anti-oxidant enzyme activities of blood fractions and the yield bleomycin-induced chromosome damage . Mut. Res. , 214 ( 1 ) : 129 – 136 .
   PubMed Web of Science ®Google Scholar