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Journal of Environmental Science and Health, Part A
Toxic/Hazardous Substances and Environmental Engineering
Volume 51, 2016 - Issue 13
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ARTICLES

Effects of anti-androgens cyproterone acetate, linuron, vinclozolin, and p,p'-DDE on the reproductive organs of the copepod Acartia tonsa

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Pages 1111-1120 | Received 26 Jan 2016, Published online: 15 Jul 2016

References

  • LeBlanc, G.A. Crustacean endocrine toxicology: A review. Ecotoxicology 2007, 16(1), 61–81.
  • LeBlanc, G.A.; Cambell, P.M.; den Besten, P.; Brown, R.P.; Chang, E.; Coats, J.; deFur, P.L.; Dhaldialla, T.; Edwards, J.; Riddiford, L.M.; Simpson, M.; Snell, T.; Thorndyke, M.; Matsumura, F. The endocrinology of invertebrates. In Endocrine Disruption in Invertebrates: Endocrinology, Testing, and Assessment; DeFur, P.L.; Crane, M.; Ingersoll, C.; Tattersfield, L., Eds.; SETAC Press: Pensacola, FL, 1999; 23–106.
  • Lafont, R.; Mathieu, M. Steroids in aquatic invertebrates. Ecotoxicology 2007, 16(1), 109–130.
  • Fingerman, M.; Nagabhushanam, R.; Sarojini, R. Vertebrate-type hormones in crustaceans: Localization, identification and functional significance. Zool. Sci. 1993, 10, 13–29.
  • Andersen, H.R.; Halling-Sørensen, B.; Kusk, K.O. A parameter for detecting estrogenic exposure in the copepod Acartia tonsa. Ecotoxicol. Environ. Saf. 1999, 44(1), 56–61.
  • Wollenberger, L.; Dinan, L.; Breitholtz, M. Brominated flame retardants: Activities in a crustacean development test and in an ecdysteroid screening assay. Environ. Toxicol. Chem. 2005, 24(2), 400–407.
  • Andersen, H.R.; Wollenberger, L.; Halling-Sørensen, B.; Kusk, K.O. Development of copepod nauplii to copepodites—A parameter for chronic toxicity including endocrine disruption. Environ. Toxicol. Chem. 2001, 20(12), 2821–2829.
  • Kusk, K.O.; Petersen, S. Acute and chronic toxicity of tributyltin and linear alkylbenzene sulfonate to the marine copepod Acartia tonsa. Environ. Toxicol. Chem. 1997, 16(8), 1629–1633.
  • Watermann, B.T.; Albanis, T.A.; Dagnac, T.; Gnass, K.; Kusk, K.O.; Sakkas, V.A.; Wollenberger, L. Effects of methyltestosterone, letrozole, triphenyltin and fenarimol on histology of reproductive organs of the copepod Acartia tonsa. Chemosphere 2013, 92(5), 544–554.
  • Schneider, H.P.G. Androgens and antiandrogens. Ann. N. Y. Acad. Sci. 2003, 997, 292–306.
  • US National Library of Medicine Hazardous Substances Data Bank (HSDB). Available at http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?HSDB (accessed May 2016).
  • Cook, J.C.; Mullin, L.S.; Frame, S.R.; Biegel, L.B. Investigation of a mechanism for Leydig cell tumorigenesis by linuron in rats. Toxicol. Appl. Pharmacol. 1993, 119(2), 195–204.
  • Lambright, C.; Ostby, J.; Bobseine, K.; Wilson, V.; Hotchkiss, A.K.; Mann, P.C.; Gray, L.E. Cellular and molecular mechanisms of action of linuron: An antiandrogenic herbicide that produces reproductive malformations in male rats. Toxicol. Sci. 2000, 56(2), 389–399.
  • McIntyre, B.S.; Barlow, N.J.; Wallace, D.G.; Maness, S.C.; Gaido, K.W.; Foster, P.M. Effects of in utero exposure to linuron on androgen-dependent reproductive development in the male Crl:CD(SD)BR rat. Toxicol. Appl. Pharmacol. 2000, 167(2), 87–99.
  • Gray, L.E.; Ostby, J.S.; Kelce, W.R. Developmental effects of an environmental antiandrogen: The fungicide vinclozolin alters sex differentiation of the male rat. Toxicol. Appl. Pharmacol. 1994, 129(1), 46–52.
  • Orton, F.; Rosivatz, E.; Scholze, M.; Kortenkamp, A. Competitive androgen receptor antagonism as a factor determining the predictability of cumulative antiandrogenic effects of widely used pesticides. Environ. Health Perspect. 2012, 120(11), 1578–1584.
  • Nyarango, P.M.; Gebremeskel, T.; Mebrahtu, G.; Mufunda, J.; Abdulmumini, U.; Ogbamariam, A.; Kosia, A.; Gebremichael, A.; Gunawardena, D.; Ghebrat, Y.; Okbaldet, Y. A steep decline of malaria morbidity and mortality trends in Eritrea between 2000 and 2004: The effect of combination of control methods. Malar. J. 2006, 5, 33.
  • Kelce, W.R.; Stone, C.R.; Laws, S.C.; Gray, L.E.; Kemppainen, J.A.; Wilson, E.M. Persistent DDT metabolite p,p’-DDE is a potent androgen receptor antagonist. Nature 1995, 375(6532), 581–585.
  • Dinan, L.; Bourne, P.; Whiting, P.; Dhadialla, T.S.; Hutchinson, T.H. Screening of environmental contaminants for ecdysteroid agonist and antagonist activity using the Drosophila melanogaster BII cell in vitro assay. Environ. Toxicol. Chem. 2001, 20(9), 2038–2046.
  • Sugni, M.; Manno, V.; Barbaglio, A.; Mozzi, D.; Bonasoro, F.; Tremolada, P.; Candia Carnevali, M.D.C. Echinoderm regenerative response as a sensitive ecotoxicological test for the exposure to endocrine disrupters: Effects of p,p’-DDE and CPA on crinoid arm regeneration. Cell Biol. Toxicol. 2008, 24(6), 573–586.
  • Sugni, M.; Tremolada, P.; Porte, C.; Barbaglio, A.; Bonasoro, F.; Carnevali, M.D.C. Chemical fate and biological effects of several endocrine disrupters compounds in two echinoderm species. Ecotoxicology 2010, 19(3), 538–554.
  • Kusk, K.O.; Wollenberger, L. Fully defined saltwater medium for cultivation of and toxicity testing with marine copepod Acartia tonsa. Environ. Toxicol. Chem. 1999, 18(7), 1564–1567.
  • International Organisation for Standardization. Water Quality—Determination of Acute Lethal Toxicity to Marine Copepods (Copepoda, Crustacea); International Standard ISO 14669:1999: Geneva, Switzerland, 1999.
  • Kusk, K.O.; Wollenberger, L. Towards an internationally harmonized test method for reproductive and developmental effects of endocrine disrupters in marine copepods. Ecotoxicology 2007, 16(1), 183–195.
  • International Organisation for Standardization. Water Quality—Calanoid Copepod Early-life Stage Test with Acartia tonsa; International Standard ISO 16778:2015: Geneva, Switzerland, 2015.
  • Woudneh, M.B.; Ou, Z.; Sekela, M.; Tuominen, T.; Gledhill, M. Pesticide multiresidues in waters of the Lower Fraser Valley, British Columbia, Canada. Part I. Surface water. J. Environ. Qual. 2009, 38(3), 940–947.
  • Ducrot, V.; Teixeira-Alves, M.; Lopes, C.; Delignette-Muller, M.-L.; Charles, S.; Lagadic, L. Development of partial life-cycle experiments to assess the effects of endocrine disruptors on the freshwater gastropod Lymnaea stagnalis: A case-study with vinclozolin. Ecotoxicology 2010, 19(7), 1312–1321.
  • Green, C.; Brian, J.; Kanda, R.; Scholze, M.; Williams, R.; Jobling, S. Environmental concentrations of anti-androgenic pharmaceuticals do not impact sexual disruption in fish alone or in combination with steroid oestrogens. Aquat. Toxicol. 2015, 160, 117–127.
  • Guo, Y.; Yu, H.-Y.; Zeng, E.Y. Occurrence, source diagnosis, and biological effect assessment of DDT and its metabolites in various environmental compartments of the Pearl River Delta, South China: A review. Environ. Pollut. 2009, 157(6), 1753–1763.
  • Xing, Y.-N.; Guo, Y.; Xie, M.; Shen, R.-L.; Zeng, E.Y. Detection of DDT and its metabolites in two estuaries of South China using a SPME-based device: First report of p,p’-DDMU in water column. Environ. Pollut. 2009, 157(4), 1382–1387.
  • Xing, Z.; Chow, L.; Cook, A.; Benoy, G.; Rees, H.; Ernst, B.; Meng, F.; Li, S.; Zha, T.; Murphy, C.; Batchelor, S.; Hewitt, L.M. Pesticide application and detection in variable agricultural intensity watersheds and their river systems in the maritime region of Canada. Arch. Environ. Contam. Toxicol. 2012, 63(4), 471–483.
  • Organisation for Economic Cooperation and Development. OECD Guidelines for Testing of Chemicals No. 211: Daphnia Magna Reproduction Test; OECD: Paris, 1998.
  • Galassi, S.; Bettinetti, R.; Neri, M.C.; Falandysz, J.; Kotecka, W.; King, I.; Lo, S.; Klingmueller, D.; Schulte-Oehlmann, U. p,p’-DDE contamination of the blood and diet in central European populations. Sci. Total Environ. 2008, 390(1), 45–52.
  • Kiørboe, T. Sex, sex-ratios, and the dynamics of pelagic copepod populations. Oecologia 2006, 148(1), 40–50.
  • Gusmao, L.F.M.; McKinnon, A.D. Sex ratios, intersexuality and sex change in copepods. J. Plankton Res. 2009, 31(9), 1101–1117.
  • Viguier-Martinez, M.-C.; Hochereau-de Reviers, M.-T. Comparative action of cyproterone and cyproterone acetate on pituitary and plasma gonadotropin levels, the male genital tract and spermatogenesis in the growing rat. Ann. Biol. Anim. Biochim. Biophys. 1977, 17(6), 1069–1076.
  • O'Connor, J.C.; Frame, S.R.; Ladics, G.S. Evaluation of a 15-day screening assay using intact male rats for identifying antiandrogens. Toxicol. Sci. 2002, 69(1), 92–108.
  • Tillmann, M.; Schulte-Oehlmann, U.; Duft, M.; Markert, B.; Oehlmann, J. Effects of endocrine disruptors on prosobranch snails (Mollusca: Gastropoda) in the laboratory. Part III: Cyproterone acetate and vinclozolin as antiandrogens. Ecotoxicology 2001, 10(6), 373–388.
  • European Commission DG ENV. Towards the Establishment of a Priority List of Substances for Further Evaluation of Their Role in Endocrine Disruption: Preparation of a Candidate List of Substances as a Basis for Priority Setting; BKH Consulting Engineers: The Netherlands, 2000.
  • Tinwell, H.; Friry-Santini, C.; Rouquié, D.; Belluco, S.; Elies, L.; Pallen, C.; Bars, R. Evaluation of the antiandrogenic effects of flutamide, DDE, and linuron in the weanling rat assay using organ weight, histopathological, and proteomic approaches. Toxicol. Sci. 2007, 100(1), 54–65.
  • Wolf, C.; Lambright, C.; Mann, P.; Price, M.; Cooper, R.L.; Ostby, J.; Gray, L.E. Administration of potentially antiandrogenic pesticides (procymidone, linuron, iprodione, chlozolinate, p,p’-DDE, and ketoconazole) and toxic substances (dibutyl- and diethylhexyl phthalate, PCB 169, and ethane dimethane sulphonate) during sexual differentiation produces diverse profiles of reproductive malformations in the male rat. Toxicol. Ind. Health 1999, 15(1–2), 94–118.
  • Marlatt, V.L.; Lo, B.P.; Ornostay, A.; Hogan, N.S.; Kennedy, C.J.; Elphick, J.R.; Martyniuk, C.J. The effects of the urea-based herbicide linuron on reproductive endpoints in the fathead minnow (Pimephales promelas). Comp. Biochem. Physiol. C Toxicol. Pharmacol. 2013, 157(1), 24–32.
  • Clement, T.M.; Savenkova, M.I.; Settles, M.; Anway, M.D.; Skinner, M.K. Alterations in the developing testis transcriptome following embryonic vinclozolin exposure. Reprod. Toxicol. 2010, 30(3), 353–364.
  • Haeba, M.H.; Hilscherová, K.; Mazurová, E.; Bláha, L. Selected endocrine disrupting compounds (vinclozolin, flutamide, ketoconazole and dicofol): Effects on survival, occurrence of males, growth, molting and reproduction of Daphnia magna. Environ. Sci. Pollut. Res. 2008, 15(3), 222–227.
  • Hiransuchalert, R.; Yocawibun, P.; Klinbunga, S.; Khamnamtong, B.; Menasveta, P. Isolation of cDNA, genomic organization and expression of small androgen receptor-interacting protein 1 (PmSARIP1) in the giant tiger shrimp Penaeus monodon. Aquaculture 2013, 412–413, 151–159.
  • Billig, H.; Furuta, I.; Hsueh, A.J. Estrogens inhibit and androgens enhance ovarian granulosa cell apoptosis. Endocrinology 1993, 133(5), 2204–2212.
  • Nakanishi, Y.; Shiratsuchi, A. Phagocytic removal of apoptotic spermatogenic cells by Sertoli cells: Mechanisms and consequences. Biol. Pharm. Bull. 2004, 27(1), 13–16.

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