Publication Cover
Journal of Environmental Science and Health, Part A
Toxic/Hazardous Substances and Environmental Engineering
Volume 54, 2019 - Issue 5
494
Views
17
CrossRef citations to date
0
Altmetric
Articles

Ecotoxicological characterization of the antiepileptic drug carbamazepine using eight aquatic species: baseline study for future higher tier tests

, , , , , , & ORCID Icon show all
Pages 441-451 | Received 01 Oct 2018, Accepted 11 Dec 2018, Published online: 21 Feb 2019

References

  • Björlenius, B.; Ripszám, M.; Haglund, P.; Lindberg, R. H.; Tysklind, M.; Fick, J. Pharmaceutical Residues Are Widespread in Baltic Sea Coastal and Offshore Waters – Screening for Pharmaceuticals and Modelling of Environmental Concentrations of Carbamazepine. Sci. Total Environ. 2018, 633, 1496–1509. DOI:10.1016/j.scitotenv.2018.03.276.
  • López-Serna, R.; Petrović, M.; Barceló, D. Occurrence and Distribution of Multi-class Pharmaceuticals and Their Active Metabolites and Transformation Products in the Ebro River Basin (NE Spain). Sci. Total Environ. 2012, 440, 280–289. DOI:10.1016/j.scitotenv.2012.06.027.
  • Luo, Y.; Guo, W.; Ngo, H. H.; Nghiem, L. D.; Hai, F. I.; Zhang, J.; Liang, S.; Wang, X. C. A Review on the Occurrence of Micropollutants in the Aquatic Environment and Their Fate and Removal during Wastewater Treatment. Sci. Total Environ. 2014, 473–474, 619–641. DOI:10.1016/j.scitotenv.2013.12.065.
  • Meyer, W.; Reich, M.; Beier, S.; Behrendt, J.; Gulyas, H.; Otterpohl, R. Measured and Predicted Environmental Concentrations of Carbamazepine, Diclofenac, and Metoprolol in Small and Medium Rivers in Northern Germany. Environ. Monit. Assess. 2016, 188, 487–487.
  • McEneff, G.; Barron, L.; Kelleher, B.; Paull, B.; Quinn, B. A Year-long Study of the Spatial Occurrence and Relative Distribution of Pharmaceutical Residues in Sewage Effluent, receiving Marine Waters and Marine Bivalves. Sci. Total Environ. 2014, 476, 317–326. DOI:10.1016/j.scitotenv.2013.12.123.
  • Schindler, W. New n-heterocyclic compounds. U.S. Patent 2948718. 1960.
  • Bernus, I.; Dickinson, R. G.; Hooper, W. D.; Eadie, M. J. Dose-Dependent Metabolism of Carbamazepine in Humans. Epilepsy Res. 1996, 24, 163–172. DOI:10.1016/0920-1211(96)00011-3
  • Jelic, A.; Gros, M.; Ginebreda, A.; Cespedes-Sánchez, R.; Ventura, F.; Petrovic, M.; Barcelo, D. Occurrence, Partition and Removal of Pharmaceuticals in Sewage Water and Sludge during Wastewater Treatment. Water Res. 2011, 45, 1165–1176. DOI:10.1016/j.watres.2010.11.010.
  • Vulliet, E.; Cren-Olivé, C. Screening of Pharmaceuticals and Hormones at the Regional Scale, in Surface and Groundwaters Intended to Human Consumption. Environ. Pollut. 2011, 159, 2929–2934. DOI:10.1016/j.envpol.2011.04.033.
  • Writer, J. H.; Ferrer, I.; Barber, L. B.; Thurman, E. M. Widespread Occurrence of Neuro-active Pharmaceuticals and Metabolites in 24 Minnesota Rivers and Wastewaters. Sci. Total Environ. 2013, 461–462, 519–527. DOI:10.1016/j.scitotenv.2013.04.099.
  • Aus der Beek, T.; Weber, F.-A.; Bergmann, A.; Hickmann, S.; Ebert, I.; Hein, A.; Küster, A. Pharmaceuticals in the Environment - Global Occurrences and Perspectives. Environ. Toxicol. Chem. 2016, 35, 823–835. DOI:10.1002/etc.3339.
  • Moermond, C. T. A.; Smit, C. E. Derivation of Water Quality Standards for Carbamazepine, Metoprolol, and Metformin and Comparison with Monitoring Data. Environ. Toxicol. Chem. 2016, 35, 882–888. DOI:10.1002/etc.3178.
  • Oekotoxzentrum, E. Q. S. Vorschlag des Oekotoxzentrums für: Carbamazepin und Haupttransformationsprodukte [EQS Proposal by Oekotoxzentrum for: Carbamazepine and Main Transformation Products]. Swiss Federal Institute of Aquatic Science and Technology (Eawag): Dübendorf, Switzerland, 2016.
  • Moermond, C. T. A, Environmental Risk Limits for Pharmaceuticals: Derivation of WFD Water Quality Standards for Carbamazepine, metoprolol, metformin and Amidotrizoic Acid. National Institute for Public Health and the Environment (RIVM): Bilthoven, 2014.
  • Wenzel, A.; Shemotyuk, L. EQS Datasheet: Environmental Quality Standard Carbamazepine. Federal Environmental Agency (UBA): Dessau-Roßlau, Germany, 2014.
  • Ferrari, B.; Paxéus, N.; Giudice, R. L.; Pollio, A.; Garric, J. Ecotoxicological Impact of Pharmaceuticals Found in Treated Wastewaters: Study of Carbamazepine, Clofibric Acid, and Diclofenac.Ecotoxicol.Environ. Saf. 2003, 55, 359–370. DOI:10.1016/S0147-6513(02)00082-9.
  • Lürling, M.; Sargant, E.; Roessink, I. Life-history Consequences for Daphnia pulex Exposed to Pharmaceutical Carbamazepine. Environ. Toxicol. 2006, 21, 172–180. DOI:10.1002/tox.20171.
  • Harris, C. A.; Scott, A. P.; Johnson, A. C.; Panter, G. H.; Sheahan, D.; Roberts, M.; Sumpter, J. P. Principles of Sound Ecotoxicology. Environ. Sci. Technol. 2014, 48, 3100–3111. DOI:10.1021/es4047507.
  • Cleuvers, M. Aquatic Ecotoxicity of Pharmaceuticals Including the Assessment of Combination Effects. Toxicol. Lett. 2003, 142, 185–194. DOI:10.1016/S0378-4274(03)00068-7.
  • Liebig, M. Untersuchungen zu Umweltrisikoabschätzungen von Humanpharmaka und Inhaltsstoffen von Körperpflegeprodukten vor dem Hintergrund europäischer Bewertungskonzepte [Environmental risk assessment of human pharmaceuticals and personal care products according to European assessment criteria]. Doctoral thesis: Goethe University Frankfurt am Main, Germany, 2005.
  • Oropesa, A. L.; Floro, A. M.; Palma, P. Assessment of the Effects of the Carbamazepine on the Endogenous Endocrine System of Daphnia Magna. Environ. Sci. Pollut. Res. 2016, 1–11. DOI:10.1007/s11356-016-6907-7
  • Lamichhane, K.; Garcia, S. N.; Huggett, D. B.; DeAngelis, D. L.; La Point, T. W. Chronic Effects of Carbamazepine on Life-history Strategies of Ceriodaphnia dubia in Three Successive Generations. Arch. Environ. Contam. Toxicol. 2013, 64, 427–438. DOI:10.1007/s00244-012-9845-5.
  • Jubeaux, G.; Simon, R.; Salvador, A.; Lopes, C.; Lacaze, E.; Quéau, H.; Chaumot, A.; Geffard, O. Vitellogenin-like Protein Measurement in Caged Gammarus fossarum Males as a Biomarker of Endocrine Disruptor Exposure: Inconclusive Experience. Aquat. Toxicol. 2012, 122-123, 9–18. DOI:10.1016/j.aquatox.2012.05.007.
  • Oetken, M.; Nentwig, G.; Löffler, D.; Ternes, T.; Oehlmann, J. Effects of Pharmaceuticals on Aquatic Invertebrates. Part I. The Antiepileptic Drug Carbamazepine. Arch. Environ. Contam. Toxicol. 2005, 49, 353–361.
  • Heye, K.; Becker, D.; Lütke Eversloh, C.; Durmaz, V.; Ternes, T. A.; Oetken, M.; Oehlmann, J. Effects of Carbamazepine and Two of Its Metabolites on the Non-biting Midge Chironomus riparius in a Sediment Full Life Cycle Toxicity Test. Water Res. 2016, 98, 19–27. DOI:10.1016/j.watres.2016.03.071.
  • Nieto, E.; Corada-Fernández, C.; Hampel, M.; Lara-Martín, P. A.; Sánchez-Argüello, P.; Blasco, J. Effects of Exposure to Pharmaceuticals (Diclofenac and Carbamazepine) spiked Sediments in the Midge, Chironomus riparius (Diptera, Chironomidae). Sci. Total Environ. 2017, 609, 715–723. DOI:10.1016/j.scitotenv.2017.07.171.
  • Ferreira da Silva, B.; Jelic, A.; López-Serna, R.; Mozeto, A. A.; Petrovic, M.; Barceló, D. Occurrence and Distribution of Pharmaceuticals in Surface Water, suspended Solids and Sediments of the Ebro River Basin, Spain. Chemosphere 2011, 85, 1331–1339. DOI:10.1016/j.chemosphere.2011.07.051.
  • OECD. OECD Guidelines for the Testing of Chemicals, No. 201: Freshwater Alga and Cyanobacteria, growth Inhibition Test. Organisation of Economic Co-operation and Development: Paris, 2006.
  • OECD. OECD Guidelines for the Testing of Chemicals No. 211: Daphnia Magna Reproduction Test. Organisation of Economic Co-operation and Development: Paris, 2012.
  • Elendt, B. P.; Bias, W. R. Trace Nutrient Deficiency in Daphnia magna Cultured in Standard Medium for Toxicity Testing. Effects of the Optimization of Culture Conditions on Life History Parameters of D. magna. Water Res. 1990, 24, 1157–1167. DOI:10.1016/0043-1354(90)90180-E.
  • US EPA. Method 1002.0: Daphnid, Ceriodaphnia dubia, survival and reproduction test; chronic toxicity. Excerpt from: Short-term Methods for Estimating the Chronic Toxicity of Effluents and Receiving Waters to Freshwater Organisms, 4th ed. EPA-821-R-02-013. US Environmental Protection Agency: Washington, DC, 2002.
  • Borgmann, U. Systematic Analysis of Aqueous Ion Requirements of Hyalella Azteca: A Standard Artificial Medium Including the Essential Bromide Ion. Arch. Environ. Contam. Toxicol. 1996, 30, 356–363. DOI:10.1007/BF00212294.
  • OECD. OECD Guideline for the Testing of Chemicals, No. 242: Potamopyrgus Antipodarum Reproduction Test. Organisation of Economic Co-operation and Development: Paris, 2016.
  • OECD. OECD Guideline for the Testing of Chemicals No. 225: Sediment-water Lumbriculus Toxicity Test Using Spiked Sediment. Organisation of Economic Co-operation and Development: Paris, 2007.
  • OECD. OECD Guidelines for the Testing of Chemicals No. 219: Sediment-water Chironomid Toxicity Using Spiked Water. Organisation of Economic Co-operation and Development: Paris, 2004.
  • EC. Technical Guidance Document on risk assessment part II, EUR 20418 EN/2 European Communities: Italy, 2003.
  • Hermes, N.; Jewell, K. S.; Wick, A.; Ternes, T. A. Quantification of More than 150 Micropollutants Including Transformation Products in Aqueous Samples by Liquid Chromatography-tandem Mass Spectrometry Using Scheduled Multiple Reaction Monitoring. J Chromatogr A 2018, 1531, 64–73. DOI:10.1016/j.chroma.2017.11.020.
  • Fenet, H.; Mathieu, O.; Mahjoub, O.; Li, Z.; Hillaire-Buys, D.; Casellas, C.; Gomez, E. Carbamazepine, Carbamazepine epoxide and Dihydroxycarbamazepine Sorption to Soil and Occurrence in a Wastewater Reuse Site in Tunisia. Chemosphere 2012, 88, 49–54. DOI:10.1016/j.chemosphere.2012.02.050.
  • Stein, K.; Ramil, M.; Fink, G.; Sander, M.; Ternes, T. A. Analysis and Sorption of Psychoactive Drugs onto Sediment. Environ. Sci. Technol. 2008, 42, 6415–6423. DOI:10.1021/es702959a.
  • Suarez, S.; Lema, J. M.; Omil, F. Removal of Pharmaceutical and Personal Care Products (PPCPs) under Nitrifying and Denitrifying Conditions. Water Res. 2010, 44, 3214–3224. DOI:10.1016/j.watres.2010.02.040.
  • Landrum, P. F.; Reinhold, M. D.; Nihart, S. R.; Eadie, B. J. Predicting the Bioavailability of Organic Xenobiotics to Pontoporeia hoyi in the Presence of Humic and Fulvic Materials and Natural Dissolved Organic Matter. Environ. Toxicol. Chem. 1985, 4, 459–467.
  • Muir, D. C. G.; Rawn, G. P.; Townsend, B. E.; Lockart, W. L.; Greenhalgh, R. Bioconcentration of Cypermethrin, Deltamethrin, Fenvalerate and Permethrin by Chironomus tentans Larvae in Sediment and Water. Environ. Toxicol. Chem. 1985, 4, 51–61. DOI:10.1002/etc.5620040108.
  • McLachlan, A. J. Sexual Dimorphism in Midges: Strategies for Flight in the Rain-pool Dweller Chironomus imicola (Diptera: Chironomidae). J. Anim. Ecol. 1986, 55, 261–267. DOI:10.2307/4706.
  • Neems, R. M.; McLachlan, A. J.; Chambers, R. Body Size and Lifetime Mating Success of Male Midges (Diptera: Chironomidae). Anim. Behav. 1990, 40, 648–652. DOI:10.1016/S0003-3472(05)80694-3.
  • Wiklund, C.; Fagerström, T. Why Do Males Emerge before Females?: A Hypothesis to Explain the Incidence of Protandry in Butterflies. Oecologia 1977, 31, 153–158. DOI:10.1007/BF00346917.
  • Hooper, H. L.; Sibly, R. M.; Hutchinson, T. H.; Maund, S. J. Joint Effects of Density and a Growth Inhibitor on the Life History and Population Growth Rate of the Midge Chironomus riparius. Environ. Toxicol. Chem. 2005, 24, 1140. DOI:10.1897/04-254R.1.
  • Sibley, P. K.; Ankley, G. T.; Benoit, D. A. Factors Affecting Reproduction and the Importance of Adult Size on Reproductive Output of the Midge Chironomus tentans. Environ. Toxicol. Chem. 2001, 20, 1296–1303. DOI:10.1897/1551-5028(2001)020<1296:FARATI>2.0.CO;2.
  • Cavallaro, M. C.; Morrissey, C. A.; Headley, J. V.; Peru, K. M.; Liber, K. Comparative Chronic Toxicity of Imidacloprid, clothianidin, and Thiamethoxam to Chironomus Dilutus and Estimation of Toxic Equivalency Factors. Environ. Toxicol. Chem. 2017, 36, 372–382. DOI:10.1002/etc.3536.
  • Postma, J. F; Buckert-de Jong, M. C.; Staats, N.; Davids, C. Chronic Toxicity of Cadmium to Chironomus riparius (Diptera: Chironomidae) at Different Food Levels. Arch. Environ. Contam. Toxicol 1994, 26, 143–148.
  • Stoughton, S. J.; Liber, K.; Culp, J.; Cessna, A. Acute and Chronic Toxicity of Imidacloprid to the Aquatic Invertebrates Chironomus tentans and Hyalella azteca under Constant- and Pulse-exposure Conditions. Arch. Environ. Contam. Toxicol. 2008, 54, 662–673. DOI:10.1007/s00244-007-9073-6.
  • Nentwig, G. Arzneimittel als Umweltrisiko? Ökotoxikologische Untersuchung und Risikobewertung für vier in der aquatischen Umwelt nachgewiesene Pharmaka [Pharmaceuticals as an environmental hazard? Ecotoxicological investigation and risk assessment of four environmentally relevant pharmaceuticals]. Doctoral Thesis: Goethe University Frankfurt am Main, Germany, 2006.
  • Hutchinson, T. H.; Solbe, J.; Kloepper-Sams, P. J. Analysis of the Ecetoc Aquatic Toxicity (EAT) database III — Comparative Toxicity of Chemical Substances to Different Life Stages of Aquatic Organisms. Chemosphere 1998, 36, 129–142. DOI:10.1016/S0045-6535(97)10025-X.
  • Williams, K. A.; Green, D. W. J.; Pascoe, D.; Gower, D. E. The Acute Toxicity of Cadmium to Different Larval Stages of Chironomus riparius (Diptera: Chironomidae) and Its Ecological Significance for Pollution Regulation. Oecologia 1986, 70, 362–366. DOI:10.1007/BF00379498.
  • Riddiford, L. M.; Truman, J. W. Hormone Receptors and the Regulation of Insect Metamorphosis. Am. Zool. 1993, 33, 340–347. DOI:10.1093/icb/33.3.340.
  • McLean, M. J.; Macdonald, R. L. Carbamazepine and 10,11-epoxycarbamazepine Produce Use- and Voltage-dependent Limitation of Rapidly Firing Action Potentials of Mouse Central Neurons in Cell Culture. J. Pharmacol. Exp. Ther 1986, 238, 727–738.
  • Elliott, P. Action of Antiepileptic and Anaesthetic Drugs on Na- and Ca-spikes in Mammalian Non-Myelinated Axons. Eur. J. Pharmacol. 1990, 175, 155–163. DOI:10.1016/0014-2999(90)90226-V.
  • Matsumoto, Y.; Enomoto, K.; Moritake, K.; Maeno, T. Effects of Carbamazepine on Nerve Activity and Transmitter Release in Neuroblastoma-Glioma Hybrid Cells and the Frog Neuromuscular Junction. Cell Biol. Toxicol 1998, 14, 191–198. DOI:10.1023/A:1007410509772.
  • Yamamura, S.; Hamaguchi, T.; Ohoyama, K.; Sugiura, Y.; Suzuki, D.; Kanehara, S.; Nakagawa, M.; Motomura, E.; Matsumoto, T.; Tanii, H.; et al. Topiramate and Zonisamide Prevent Paradoxical Intoxication Induced by Carbamazepine and Phenytoin. Epilepsy Res 2009, 84, 172–186. DOI:10.1016/j.eplepsyres.2009.01.015.
  • Martin-Diaz, L.; Franzellitti, S.; Buratti, S.; Valbonesi, P.; Capuzzo, A.; Fabbri, E. Effects of Environmental Concentrations of the Antiepilectic Drug Carbamazepine on Biomarkers and cAMP-mediated Cell Signaling in the Mussel Mytilus galloprovincialis. Aquat. Toxicol 2009, 94, 177–185. DOI:10.1016/j.aquatox.2009.06.015.
  • Dussault, E. B.; Balakrishnan, V. K.; Sverko, E.; Solomon, K. R.; Sibley, P. K. Toxicity of Human Pharmaceuticals and Personal Care Products to Benthic Invertebrates. Environ. Toxicol. Chem 2008, 27, 425–432. DOI:10.1897/07-354R.1.
  • Baird, D. J.; Barber, I.; Bradley, M.; Soares, A. M. V. M.; Calow, P. A Comparative Study of Genotype Sensitivity to Acute Toxic Stress Using Clones of Daphnia magna Straus. Ecotoxicol. Environ. Saf 1991, 21, 257–265. DOI:10.1016/0147-6513(91)90064-V.
  • Cowgill, U. M. Critical Analysis of Factors Affecting the Sensitivity of Zooplankton and the Reproducibility of Toxicity Test Results. Water Res. 1987, 21, 1453–1462. DOI:10.1016/0043-1354(87)90128-X.
  • US EPA. Pesticide Fact Sheet: Cyprodinil. US Environmental Proctection Agency: Washington, 1998.
  • Loos, R.; Gawlik, B. M.; Locoro, G.; Rimaviciute, E.; Contini, S.; Bidoglio, G. EU-wide Survey of Polar Organic Persistent Pollutants in European River Waters. Environ. Pollut. 2009, 157, 561–568. DOI:10.1016/j.envpol.2008.09.020.
  • Brezina, E.; Prasse, C.; Meyer, J.; Mückter, H.; Ternes, T. A. Investigation and Risk Evaluation of the Occurrence of Carbamazepine, Oxcarbazepine, their Human Metabolites and Transformation Products in the Urban Water Cycle. Environ. Pollut. 2017, 225, 261–269. DOI:10.1016/j.envpol.2016.10.106.
  • Minguez, L.; Pedelucq, J.; Farcy, E.; Ballandonne, C.; Budzinski, H.; Halm-Lemeille, M.-P. Toxicities of 48 Pharmaceuticals and Their Freshwater and Marine Environmental Assessment in Northwestern France. Environ. Sci. Pollut. Res. 2014,
  • Berger, E.; Haase, P.; Oetken, M.; Sundermann, A. Field Data Reveal Low Critical Chemical Concentrations for River Benthic Invertebrates. Sci. Total Environ. 2016, 544, 864–873. DOI:10.1016/j.scitotenv.2015.12.006.
  • Jarvis, A. L.; Bernot, M. J.; Bernot, R. J. The Effects of the Psychiatric Drug Carbamazepine on Freshwater Invertebrate Communities and Ecosystem Dynamics. Sci. Total Environ. 2014, 496, 461–470. DOI:10.1016/j.scitotenv.2014.07.084.
  • Liess, M.; Foit, K.; Knillmann, S.; Schäfer, R. B.; Liess, H.-D. Predicting the Synergy of Multiple Stress Effects. Sci. Rep. 2016, 6, 32965. DOI:10.1038/srep32965.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.