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Journal of Environmental Science and Health, Part A
Toxic/Hazardous Substances and Environmental Engineering
Volume 55, 2020 - Issue 10
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Research Article

Blood lead level (BLL), δ-aminolevulinic acid dehydratase activity (ALAD), hemoglobin (Hb) and hematocrit (hct) in primary school-children and adult residents living in smelter rural areas in Kosovo

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Pages 1179-1187 | Received 18 Feb 2020, Accepted 04 Jun 2020, Published online: 22 Jun 2020

References

  • Flora, G.; Gupta, D.; Tiwari, A. Toxicity of Lead: A Review with Recent Updates. Interdiscip. Toxicol. 2012, 5, 47–58. DOI: 10.2478/v10102-012-0009-2.
  • Clune, A. L.; Falk, H.; Riederer, A. M. Mapping Global Environmental Lead Poisoning Children. J. Health Pollut. 2011, 1, 14–23. DOI: 10.5696/2156-9614.1.2.14..
  • Taylor, M. P.; Winder, C.; Lanphear, B. P. Australia's leading public health body delays action on the revision of the public health goal for blood lead exposures. Environ. Int. 2014, 70, 113–117. DOI: 10.1016/j.envint.2014.04.023.
  • Parry, Y. J. Metal Smelting Plants Poison Hundreds of Chinese Children. BMJ 2009, 339, b3433 DOI: 10.1136/bmj.b3433.
  • Sullivan, M. Reducing Lead in Air and Preventing Childhood Exposure near Lead Smelters: Learning from the U.S. experience. New Solut. 2015, 25, 78–101. DOI: 10.1177/1048291115569027.
  • Popovac, D.; Graziano, J.; Seaman, C.; Colakovic, B.; Popovac, R.; Osmani, I.; Haxhiu, M.; Begraca, M.; Bozovic, Z.; Mikic, M.; Kaul, B. Elevated Blood lead in a population near a lead smelter in Kosovo, Yugoslavia. Arch. Environ. Health. 1982, 37, 19–23. DOI: 10.1080/00039896.1982.10667527.
  • Graziano, J. S.; Dusan Popovac, D.; Factor-Litvak, P.; Shrout, P.; Kline, J.; Murphy, J.; Zhao, M. J.; Mehmeti, Y.; Ahmedi, A.; Rajovic, X.; et al. Determinants of Elevated Blood Lead during Pregnancy in a Population Surrounding a Lead Smelter in Kosovo, Yugoslavia. Environ. Health Perspect. 1990, 89, 95–10. DOI: 10.1289/ehp.908995.
  • Wasserman, G.; Graziano, J. H.; Factor-Litvak, P.; Popovac, D.; Morina, N.; Musabegovic, A.; Vrenezi, N.; Capuni-Paracka, S.; Lekic, V.; Preteni-Redjepi, E.; et al. Independent Effects of Lead Exposure and Iron Deficiency Anemia and on Development Outcomes at Age 2 Years. J. Pediatr. 1992, 121, 695–703. DOI: 10.1016/S0022-3476(05)81895-5.
  • Factor-Litvak, P.; Wasserman, G.; Kline, J. K.; Graziano, J. The Yugoslavia p Rospective Study of Environmental Lead Exposure. Environ. Health Perspect. 1999, 107, 9–15. DOI: 10.1289/eph.991079.
  • Factor -Litvak, P.; Kline, J.; Popovac, D.; Hadzhialjevic, S.; Lekic, V.; Preteni-Rexhepi, E.; Capuni-Paracka, S.; Slavcovich, V.; Graziano, J. H. Blood Lead and Blood Pressure in Young Children. Epidemiology 1996, 7, 633–637.
  • Factor-Litvak, P.; Slavkovich, V.; Liu, X.; Popovac, D.; Preteni, E.; Capuni-Paracka, S.; Hadzialjevic, S.; Lekic, V.; LoIacono, N.; Kline, J.; Graziano, J. Hyperproduction of erythropoietin in nonanemic lead-exposed children. Environ. Health Perspect. 1998, 106, 361–364. DOI: 10.1289/ehp.98106361.
  • Graziano, J.; Slavkovich, V.; Liu, X.; Factor-Litvak, P.; Todd, A. A Prospective Study of Prenatal and Childhood Lead Exposure and erythropoietin production. J. Occup. Environ. Med. 2004, 46, 924–929. DOI: 10.1097/01.jom.0000137721.95544.4f.
  • Camaj, P. R.; Graziano, J. H.; Preteni, E.; Popovac, D.; LoIacono, N.; Balac, O.; Factor-Litvak, P. Long-Term Effects of Environmental Lead Exposure on Blood Pressure and Plasma Soluble Cell Adhesion Molecules in Young Adults: A Follow-Up Study of a Prospective Cohort in Kosovo. J. Environ. Public Health 2018, 2018, 2018, 3180487–3180410. DOI: 10.1155/2018/3180487.
  • U.S. EPA. Integrated Science Assessment for Lead. EPA/600/R-10/075B U.S. EPA. Integrated Science Assessment (ISA) for Lead (Second External Review Draft, Mar 2012). U.S. Environmental Protection Agency, Washington, DC, EPA/600/R-10/075B, 2012.
  • Stewart, W. F.; Schwartz, B. S. Effects of Lead on the Adult Brain: A 15-year exploration. Am. J. Ind. Med. 2007, 50, 729–739. DOI: 10.1002/ajim.20434.
  • Bellinger, D. C. Environmental Chemical Exposures and Neurodevelopment Impairments in Children. Pediatr. Med 2018, 1, 1–13. DOI: 10.21037/pm.2018.11.03..
  • Tsoi, M.-F.; Cheung, C.-L.; Cheung, T. T.; Cheung, B. M. Y. Continual Decrease in Blood Lead Levels in Americans: United States National Health Nutrition Examination Survey. 1999-2014. Am. J. Med. 2016, 129, 1213–1218. DOI: 10.1016/j.amjmed.2016.05.042.
  • Murata, K.; Iwata, T.; Dakeishi, M.; Karita, K. Lead Toxicity: Does the Critical Level of Lead Resulting in Adverse Effects differ between adults and children?. J. Occup. Health. 2009, 51, 1–12. DOI: 10.1539/joh.k8003.
  • Elezaj, I. R.; Letaj, K.; Rr, Selimi, Q. I.; Rrustemi, A.; Zogaj, D.; Sefaja, L. Blood Lead Level and δ-Aminolevulinic Acid Dehydratase Activity in Pre-Menopausal and Post-Menopausal Women. J. Chem. Health Risk 2012, 12, 1–6. DOI: 10.22034/JCHR.2012.543989.
  • Šajn, R.; Aliu, M.; Stafilov, T.; Alijagic, J. Heavy Metal Contamination of Topsoil around a Lead and Zinc Smelter in Mitrovicë. Kosovë. J. Geochem. Explor. 2013, 134, 1–16. doi: 200210.1016/j.gexplo.2013.06.018. DOI: 10.1016/j.gexplo.2013.06.018.
  • Provisional Self Government in Kosovo Ministry of Health and National Institute for Research on Food and Nutrition-Italy (UNICEF) (2002),” Micro-nutrient status Survey in Kosovo, 2002.
  • Berlin, A.; Schaller, K. H. European Standardized Method for the Determination of Delta- Aminolevulinic Acid Dehydratase Activity in Blood. Z Klin. Chem. Klin. Biochem. 1974, 12, 389–390.
  • KutllovciZogaj, D.; Krasniqi, S.; Elezaj, I.; Ramadani, N.; Gjergji, T.; Zogaj, D.; Kutllovci, A.; Jaka, A.; Ukhaxhaj, A.; Gashi, S.; Bince, E. Correlation between Blood Lead Level and Hemoglobin Level in Mitrovica Children. Med. Arh. 2014, 68, 324–328. DOI: 10.5455/medarh.2014.68.324-328.
  • Centers for Disease Control and Prevention. CDC response to Advisory Committee on Childhood Lead Poisoning Prevention. Recommendations in “Low Level Lead Exposure Harms Children: a renewed call of primary prevention” [Internet]. Atlanta: CDC; 2013.
  • Oulhote, Y.; Le Bot, B.; Poupon, J.; Lucas, J.-P.; Mandin, C.; Etchevers, A.; Zmirou-Navier, D.; Glorennec, P. Identification of Sources of Lead Exposure in French Children by Lead Isotope Analysis: A Cross-Sectional Study. Environ Health 2011, 10, 75–11. DOI: 10.1186/1476-069X-10-75.
  • Yoshinaga, J. Lead in the Japanese Living Environment. Environ Health Prev Med 2012, 17, 433–443. DOI: 10.1007/s12199-012-0280-z.
  • Jež, E.; Lestan, D. Prediction of Blood Lead Levels in children before and after remediation of soil samples in the upper Meza Valley, Slovenia. J. Hazard. Mater. 2015, 296, 138–146. DOI: 10.1016/j.jhazmat.2015.04.049.
  • Kowalska, M.; Kulka, E.; Jarosz, W.; Kowalski, M. The Determinants of Lead and Cadmium Blood levels for preschool children from industrially contaminated sites in Poland. Int. J. Occup. Med. Environ. Health. 2018, 31, 351–359. DOI: 10.13075/ijomeh.1896.01153.
  • Gao, Z.; Cao, J.; Yan, J.; Wang, J.; Cai, S.; Yan, C. Blood Lead Levels and Risk Factors among Preschool Children in a Lead Polluted Area in Taizhou, China. Biomed Res Int . 2017, 2017, 4934198 . DOI: 10.1155/2017/4934198.
  • Prihartono, N. A.; Djuwita, R.; Mahmud, P. B.; Haryanto, B.; Helda, H.; Wahyono, T. Y. M.; Dignam, T. Prevalence of Blood Lead among Children Living in the Battery Recycling Communities in Greater Jakarta, Indonesia. IJERPH. 2019, 16, 1276. 16071276. DOI: 10.3390/ijerph.
  • Brown, M. J.; McWeeney, G.; Kim, R.; Tahirukaj, A.; Bulat, P.; Syla, S.; Savic, Z.; Amitai, Y.; Dignam, T.; Kaluski, D. N. Lead Poisoning among Internally Displaced Roma, Ashkali and Egyptian Children in the United Nations-Administered Province of Kosovo. Eur. J. Public Health. 2010, 20, 288–292. DOI: 10.1093/eurpub/ckp164.
  • Shabani, D.; Murtezani, A.; Tahirbegolli, B.; Bozalija, A.; Alili-Idrizi, E.; Ibraimi, Z. Blood Lead Level of Children and Its Trend in Mitrovica. JCS. 2019, 09, e84–e89. DOI: 10.1055/s-0039-1693515.
  • Diawara, M.; Shrestha, S.; Carsella, J.; Farmer, S. Smelting Remains a Public Health Risk Nearly a Century Later: A Case Study in Pueblo, Colorado, USA. IJERPH. 2018, 15, 932. pii: E932. DOI: 10.3390/ijerph15050932.
  • La-Llave-León, O.; Méndez-Hernández, E.; Castellanos-Juárez, F.; Esquivel-Rodríguez, E.; Vázquez-Alaniz, F.; Sandoval-Carrillo, A.; García-Vargas, G.; Duarte-Sustaita, J.; Candelas-Rangel, J.; Salas-Pacheco, J. Association between Blood Lead Levels and Delta-Aminolevulinic Acid Dehydratase in Pregnant Women. IJERPH. 2017, 14, 432. pii: E432. DOI: 10.3390/ijerph14040432.
  • Bergomi, M.; Borella, P.; Fantuzzi, G.; Vivoli, G.; Sturloni, N.; Cavazzuti, G.; Tampieri, A.; Tartoni, P. L. Relationship between Lead Exposure Indicators and Neuropsychological Performance in Children. Dev Med Child Neurol 1989, 31, 181–190. DOI: 10.1111/j.1469-8749.1989.tb03977.x.
  • Wang, Q.; Ye, L. X.; Zhao, H. H.; Chen, J. W.; Zhou, Y. K. Benchmark Dose Approach for low-level lead induced haematogenesis inhibition and associations of childhood intelligences with ALAD activity and ALA levels . Sci. Total Environ. 2011, 409, 1806–1810. DOI: 10.1016/j.scitotenv.2011.01.045.
  • Bradberry, S.; Vale, A. Specific Substances Lead and Mercury. Medicine 2007, 35, 627–628. DOI: 10.1016/j.mpmed.2007.09.004.
  • Ahamed, M.; Akhtar, M. J.; Verma, S.; Kumar, A.; Siddiqui, M. K. J. Environmental Lead Exposure as a Risk for Childhood Aplastic Anemia. Bst. 2011, 5, 38–43. DOI: 10.5582/bst.2011.v5.1.38.
  • Kasperczyk, A.; Machnik, G.; Dobrakowski, M.; Sypniewski, D.; Birkner, E.; Kasperczyk, S. Gene Expression and Activity of Antioxidant Enzymes in the Blood cells of workers who were occupationally exposed to lead. Toxicology 2012, 301, 79–84. DOI: 10.1016/j.tox.2012.07.002.
  • Kasperczyk, S.; Dobrakowski, M.; Ostałowska, A.; Kasperczyk, A.; Wilczyiński, S.; Wyparło-Wszelaki, M.; Kiełtucki, J.; Birkner, E. Lead-Elevated Activity of Xanthine Oxidase in Lead-Exposed Workers. Med. Pr. 2013, 64, 175–180. doi: . DOI: 10.13075/mp.5893/2013/0013.
  • Makino, S.; Shimizu, Y.; Takata, T. A Study on the Relationship between Blood Lead Levels and Anemia Indicators in Workers Exposed to Low Levels of Lead. Indust. Health 1997, 35, 537–541. DOI: 10.2486/indhealth.35.537.
  • Hu, H.; Watanabe, H.; Payton, M.; Korrick, S.; Rotnitzky, A. The Relationship between Bone Lead and Hemoglobin. JAMA. 1994, 272, 1512–1517. DOI: 10.1001/jama.1994.03520190058035.
  • Sudjaroen, Y.; Suwannahong, K. Biomarker Related Lead Exposure of Industrial Battery’s Workers. Ann. Trop. Med. Public Health 2017, 10, 194–198. DOI: 10.4103/1755-6783.196523.
  • Berisha, V. N.; Bakalli, R. I.; Elezaj, I.; Selimi, Q.; Reçi, H. The Relationship between Erythrocyte Delta Aminolevulinic Acid Dehydratase (ALAD) and Lead Levels in the Blood of School Age Children Living in the Community of Mitrovicë. Kosova. Faseb J. 2000, 14, A230. 165.5
  • Liu, C.; Huo, X.; Lin, P.; Zhang, Y.; Li, W.; Xu, X. Association between Blood Erythrocyte Lead Concentrations and Hemoglobin Levels in Preschool Children. Environ. Sci. Pollut. Res. Int. 2015, 22, 9233–9240. DOI: 10.1007/s11356-014-3992-3.
  • Gilbert, S. G.; Weiss, B. A Rationale for Lowering the Blood Lead Action Level from 10 to 2 microg/dL. Neurotoxicology 2006, 27, 693–701. DOI: 10.1016/j.neuro.2006.06.008.

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