References
- Khan, J. Z.; Sun, L.; Tian, Y.; Shi, G.; Feng, Y. Chemical Characterization and Source Apportionment of PM1 and PM2.5 in Tianjin, China: Impacts of Biomass Burning and Primary Biogenic Sources. J Environ Sci. 2021, 99, 196–209. DOI: https://doi.org/10.1016/j.jes.2020.06.027.
- Ambient (outdoor) Air Pollution. https://www.who.int/news-room/fact-sheets/detail/ambient-(outdoor)-air-quality-and-health (accessed Sep. 2021).
- Lewtas, J. Air Pollution Combustion Emissions: Characterization of Causative Agents and Mechanisms Associated with Cancer, Reproductive, and Cardiovascular Effects. Mutat Res. 2007, 636, 95–133. DOI: https://doi.org/10.1016/j.mrrev.2007.08.003.
- Farina, F.; Lonati, E.; Milani, C.; Massimino, L.; Ballarini, E.; Donzelli, E.; Crippa, L.; Marmiroli, P.; Botto, L.; Corsetto, P. A.; et al. In Vivo Comparative Study on Acute and Sub-Acute Biological Effects Induced by Ultrafine Particles of Different Anthropogenic Sources in BALB/c Mice. IJMS. 2019, 20, 2805. DOI: https://doi.org/10.3390/ijms20112805.
- Steiner, S.; Bisig, C.; Petri-Fink, A.; Rothen-Rutishauser, B. Diesel Exhaust: current Knowledge of Adverse Effects and Underlying Cellular Mechanisms the Diesel Engine: Opportunity and Challenge. Arch Toxicol. 2016, 90, 1541–1553. DOI: https://doi.org/10.1007/s00204-016-1736-5.
- Chuang, H.-C.; Cheng, Y.-L.; Lei, Y.-C.; Chang, H.-H.; Cheng, T.-J. Protective Effects of Pulmonary Epithelial Lining Fluid on Oxidative Stress and DNA Single-Strand Breaks Caused by Ultrafine Carbon Black, Ferrous Sulphate and Organic Extract of Diesel Exhaust Particles. Toxicol Appl Pharmacol. 2013, 266, 329–334. DOI: https://doi.org/10.1016/j.taap.2012.12.004.
- Forchhammer, L.; Loft, S.; Roursgaard, M.; Cao, Y.; Riddervold, I. S.; Sigsgaard, T.; Møller, P. Expression of Adhesion Molecules, Monocyte Interactions and Oxidative Stress in Human Endothelial Cells Exposed to Wood Smoke and Diesel Exhaust Particulate Matter. Toxicol Lett. 2012, 209, 121–128. DOI: https://doi.org/10.1016/j.toxlet.2011.12.003.
- Steiner, S.; Czerwinski, J.; Comte, P.; Popovicheva, O.; Kireeva, E.; Müller, L.; Heeb, N.; Mayer, A.; Fink, A.; Rothen-Rutishauser, B. Rothen-Rutishauser, B. Comparison of the Toxicity of Diesel Exhaust Produced by Bio- and Fossil Diesel Combustion in Human Lung Cells in Vitro. Atmos. Environ. 2013, 81, 380–388. DOI: https://doi.org/10.1016/j.atmosenv.2013.08.059.
- Jaramillo, I. C.; Sturrock, A.; Ghiassi, H.; Woller, D. J.; Deering-Rice, C. E.; Lighty, J. S.; Paine, R.; Reilly, C.; Kelly, K. E. Effects of Fuel Components and Combustion Particle Physicochemical Properties on Toxicological Responses of Lung Cells. J Environ Sci Health A Tox Hazard Subst Environ Eng. 2018, 53, 295–309. DOI: https://doi.org/10.1080/10934529.2017.1400793.
- Lichtveld, K. M.; Ebersviller, S. M.; Sexton, K. G.; Vizuete, W.; Jaspers, I.; Jeffries, H. E. In Vitro Exposures in Diesel Exhaust Atmospheres: Resuspension of PM from Filters versus Direct Deposition of PM from Air. Environ Sci Technol. 2012, 46, 9062–9070. DOI: https://doi.org/10.1021/es301431s.
- Fox, J. R.; Cox, D. P.; Drury, B. E.; Gould, T. R.; Kavanagh, T. J.; Paulsen, M. H.; Sheppard, L.; Simpson, C. D.; Stewart, J. A.; Larson, T. V.; Kaufman, J. D. Chemical Characterization and in Vitro Toxicity of Diesel Exhaust Particulate Matter Generated under Varying Conditions. Air Qual Atmos Health. 2015, 8, 507–519. DOI: https://doi.org/10.1007/s11869-014-0301-8.
- Kaur, K.; Mohammadpour, R.; Jaramillo, I.; Ghandehari, H.; Reilly, C.; Paine, R.; Kelly, K. Application of a Quartz Crystal Microbalance to Measure the Mass Concentration of Combustion Particle Suspensions. J. Aerosol Sci. 2019, 137, 105445. DOI: https://doi.org/10.1016/j.jaerosci.2019.105445.
- Lenz, A. G.; Karg, E.; Lentner, B.; Dittrich, V.; Brandenberger, C.; Rothen-Rutishauser, B.; Schulz, H.; Ferron, G. A.; Schmid, O. A Dose-Controlled System for Air-Liquid Interface Cell Exposure and Application to Zinc Oxide Nanoparticles. Part. Fibre Toxicol. 2009, 6, 32. DOI: https://doi.org/10.1186/1743-8977-6-32.
- Ihalainen, M.; Jalava, P.; Ihantola, T.; Kasurinen, S.; Uski, O.; Sippula, O.; Hartikainen, A.; Tissari, J.; Kuuspalo, K.; Lähde, A.; et al. Design and Validation of an Air-Liquid Interface (ALI) Exposure Device Based on Thermophoresis. Aerosol Sci. Technol. 2019, 53, 133–145. DOI: https://doi.org/10.1080/02786826.2018.1556775.
- Aufderheide, M.; Halter, B.; Möhle, N.; Hochrainer, D. The CULTEX RFS: A Comprehensive Technical Approach for the in Vitro Exposure of Airway Epithelial Cells to the Particulate Matter at the Air-Liquid Interface. Biomed Res. Int. 2013, 2013, 1–15. DOI: https://doi.org/10.1155/2013/734137.
- Volckens, J.; Dailey, L.; Walters, G.; Devlin, R. B.; Devlin, R. Direct Particle-to-Cell Deposition of Coarse Ambient Particulate Matter Increases the Production of Inflammatory Mediators from Cultured Human Airway Epithelial Cells. Environ Sci Technol. 2009, 43, 4595–4599. DOI: https://doi.org/10.1021/es900698a.
- Zavala, J.; Lichtveld, K.; Ebersviller, S.; Carson, J. L.; Walters, G. W.; Jaspers, I.; Jeffries, H. E.; Sexton, K. G.; Vizuete, W. The Gillings Sampler-An Electrostatic Air Sampler as an Alternative Method for Aerosol In Vitro Exposure Studies. Chem Biol Interact. 2014, 220, 158–168. DOI: https://doi.org/10.1016/j.cbi.2014.06.026.
- Tilly, T. B.; Ward, R. X.; Luthra, J. K.; Robinson, S. E.; Eiguren-Fernandez, A.; Lewis, G. S.; Salisbury, R. L.; Lednicky, J. A.; Sabo-Attwood, T. L.; Hussain, S. M.; Wu, C.-Y. Condensational Particle Growth Device for Reliable Cell Exposure at the Air–Liquid Interface to Nanoparticles. Aerosol Sci. Technol. 2019, 53, 1415–1428. DOI: https://doi.org/10.1080/02786826.2019.1659938.
- Kaur, K.; Jaramillo, I. C.; Mohammadpour, R.; Sturrock, A.; Ghandehari, H.; Reilly, C.; Paine, R.; Kelly, K. E. Effect of Collection Methods on Combustion Particle Physicochemical Properties and Their Biological Response in a Human Macrophage-like Cell Line. J Environ Sci Health A Tox Hazard Subst Environ Eng. 2019, 54, 1170–1185. DOI: https://doi.org/10.1080/10934529.2019.1632626.
- Secondo, L. E.; Liu, N. J.; Lewinski, N. A. Methodological Considerations When Conducting in Vitro, Air-Liquid Interface Exposures to Engineered Nanoparticle Aerosols. Crit Rev Toxicol. 2017, 47, 225–262. DOI: https://doi.org/10.1080/10408444.2016.1223015.
- Maikawa, C. L.; Zimmerman, N.; Rais, K.; Shah, M.; Hawley, B.; Pant, P.; Jeong, C.-H.; Delgado-Saborit, J. M.; Volckens, J.; Evans, G.; et al. Murine Precision-Cut Lung Slices Exhibit Acute Responses following Exposure to Gasoline Direct Injection Engine Emissions. Sci. Total Environ. 2016, 568, 1102–1109. DOI: https://doi.org/10.1016/j.scitotenv.2016.06.173.
- Holder, A. L.; Lucas, D.; Goth-Goldstein, R.; Koshland, C. P. Cellular Response to Diesel Exhaust Particles Strongly Depends on the Exposure Method. Toxicol Sci. 2008, 103, 108–115. DOI: https://doi.org/10.1093/toxsci/kfn014.
- Tomašek, I.; Horwell, C. J.; Damby, D. E.; Barošová, H.; Geers, C.; Petri-Fink, A.; Rothen-Rutishauser, B.; Clift, M. J. D. Combined Exposure of Diesel Exhaust Particles and Respirable Soufrière Hills Volcanic Ash Causes a (Pro-)Inflammatory Response in an in Vitro Multicellular Epithelial Tissue Barrier Model. Part Fibre Toxicol. 2016, 13, 67. DOI: https://doi.org/10.1186/s12989-016-0178-9.
- Barosova, H.; Chortarea, S.; Peikertova, P.; Clift, M. J. D.; Petri-Fink, A.; Kukutschova, J.; Rothen-Rutishauser, B. Biological Response of an in Vitro Human 3D Lung Cell Model Exposed to Brake Wear Debris Varies Based on Brake Pad Formulation. Arch Toxicol. 2018, 92, 2339–2351. DOI: https://doi.org/10.1007/s00204-018-2218-8.
- Endes, C.; Schmid, O.; Kinnear, C.; Mueller, S.; Camarero-Espinosa, S.; Vanhecke, D.; Foster, E. J.; Petri-Fink, A.; Rothen-Rutishauser, B.; Weder, C.; Clift, M. J. An in Vitro Testing Strategy towards Mimicking the Inhalation of High Aspect Ratio Nanoparticles. Part. Fibre Toxicol. 2014, 11, 40. DOI: https://doi.org/10.1186/s12989-014-0040x.
- Lovén, K.; Dobric, J.; Bölükbas, D. A.; Kåredal, M.; Tas, S.; Rissler, J.; Wagner, D. E.; Isaxon, C. Toxicological Effects of Zinc Oxide Nanoparticle Exposure: An In Vitro Comparison between Dry Aerosol air-Liquid Interface and Submerged Exposure Systems. Nanotoxicology. 2021, 15, 494–510. DOI: https://doi.org/10.1080/17435390.2021.1884301.
- Ghio, A. J.; Dailey, L. A.; Soukup, J. M.; Stonehuerner, J.; Richards, J. H.; Devlin, R. B. Growth of Human Bronchial Epithelial Cells at an Air-Liquid Interface Alters the Response to Particle Exposure. Part Fibre Toxicol. 2013, 10, 25. DOI: https://doi.org/10.1186/1743-8977-10-25.
- Stoehr, L. C.; Madl, P.; Boyles, M. S. P.; Zauner, R.; Wimmer, M.; Wiegand, H.; Andosch, A.; Kasper, G.; Pesch, M.; Lütz-Meindl, U.; et al. Enhanced Deposition by Electrostatic Field-Assistance Aggravating Diesel Exhaust Aerosol Toxicity for Human Lung Cells. Environ Sci Technol. 2015, 49, 8721–8730. DOI: https://doi.org/10.1021/acs.est.5b02503.
- Daigneault, M.; Preston, J. a.; Marriott, H. M.; Whyte, M. K. B.; Dockrell, D. H. The Identification of Markers of Macrophage Differentiation in PMA-Stimulated THP-1 Cells and Monocyte-Derived Macrophages. PLoS One. 2010, 5, e8668. DOI: https://doi.org/10.1371/journal.pone.0008668.
- Kasurinen, S.; Happo, M. S.; Rönkkö, T. J.; Orasche, J.; Jokiniemi, J.; Kortelainen, M.; Tissari, J.; Zimmermann, R.; Hirvonen, M.-R.; Jalava, P. I. Differences between co-Cultures and Monocultures in Testing the Toxicity of Particulate Matter Derived from Log Wood and Pellet Combustion. PLoS One. 2018, 13, e0192453. DOI: https://doi.org/10.1371/journal.pone.0192453.
- Wang, G.; Zhang, X.; Liu, X.; Zheng, J.; Chen, R.; Kan, H. Ambient Fine Particulate Matter Induce Toxicity in Lung Epithelial-Endothelial co-Culture Models. Toxicol Lett. 2019, 301, 133–145. DOI: https://doi.org/10.1016/j.toxlet.2018.11.010.
- Livak, K. J.; Schmittgen, T. D. Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 2001, 25, 402–408. DOI: https://doi.org/10.1006/meth.2001.1262.
- Murdock, R. C.; Braydich-Stolle, L.; Schrand, A. M.; Schlager, J. J.; Hussain, S. M. Characterization of Nanomaterial Dispersion in Solution Prior to in Vitro Exposure Using Dynamic Light Scattering Technique. Toxicol Sci. 2008, 101, 239–253. DOI: https://doi.org/10.1093/toxsci/kfm240.
- Dhital, N. B.; Wang, S.-X.; Lee, C.-H.; Su, J.; Tsai, M.-Y.; Jhou, Y.-J.; Yang, H.-H. Effects of Driving Behavior on Real-World Emissions of Particulate Matter, Gaseous Pollutants and Particle-Bound PAHs for Diesel Trucks. Environ. Pollut. 2021, 286, 117292. DOI: https://doi.org/10.1016/j.envpol.2021.117292.
- Kocbach, A.; Namork, E.; Schwarze, P. E. Pro-Inflammatory Potential of Wood Smoke and Traffic-Derived Particles in a Monocytic Cell Line. Toxicology. 2008, 247, 123–132. DOI: https://doi.org/10.1016/j.tox.2008.02.014.
- Jalava, P. I.; Salonen, R. O.; Nuutinen, K.; Pennanen, A. S.; Happo, M. S.; Tissari, J.; Frey, A.; Hillamo, R.; Jokiniemi, J.; Hirvonen, M. Effect of Combustion Condition on Cytotoxic and Inflammatory Activity of Residential Wood Combustion Particles. Atmos. Environ. 2010, 44, 1691–1698. DOI: https://doi.org/10.1016/j.atmosenv.2009.12.034.
- Schmid, O.; Cassee, F. R. On the Pivotal Role of Dose for Particle Toxicology and Risk Assessment: exposure is a Poor Surrogate for Delivered Dose. Part Fibre Toxicol. 2017, 14, 52. DOI: https://doi.org/10.1186/s12989-017-0233-1.
- Manzano-León, N.; Serrano-Lomelin, J.; Sánchez, B. N.; Quintana-Belmares, R.; Vega, E.; Vázquez-López, I.; Rojas-Bracho, L.; López-Villegas, M. T.; Vadillo-Ortega, F.; Vizcaya-Ruiz, A.; et al. TNFα and IL-6 Responses to Particulate Matter in Vitro: Variation according to PM Size, Season, and Polycyclic Aromatic Hydrocarbon and Soil Content. Environ Health Perspect. 2016, 124, 406–412. DOI: https://doi.org/10.1289/ehp.1409287.
- Jalava, P. I.; Hirvonen, M.-R.; Sillanpää, M.; Pennanen, A. S.; Happo, M. S.; Hillamo, R.; Cassee, F. R.; Gerlofs-Nijland, M.; Borm, P. J. A.; Schins, R. P. F.; et al. Associations of Urban Air Particulate Composition with Inflammatory and Cytotoxic Responses in RAW 246.7 Cell Line. Inhal Toxicol. 2009, 21, 994–1006. DOI: https://doi.org/10.1080/08958370802695710.
- Drasler, B.; Sayre, P.; Steinhäuser, K. G.; Petri-Fink, A.; Rothen-Rutishauser, B. Rothen-Rutishauser, B. In Vitro Approaches to Assess the Hazard of Nanomaterials. NanoImpact. 2017, 8, 99–116. DOI: https://doi.org/10.1016/j.impact.2017.08.002.
- Monteiller, C.; Tran, L.; MacNee, W.; Faux, S.; Jones, A.; Miller, B.; Donaldson, K. The Pro-Inflammatory Effects of Low-Toxicity Low-Solubility Particles, Nanoparticles and Fine Particles, on Epithelial Cells in Vitro: The Role of Surface Area. Occup Environ Med. 2007, 64, 609–615. DOI: https://doi.org/10.1136/oem.2005.024802.
- Stoeger, T.; Reinhard, C.; Takenaka, S.; Schroeppel, A.; Karg, E.; Ritter, B.; Heyder, J.; Schulz, H. Instillation of Six Different Ultrafine Carbon Particles Indicates a Surface Area Threshold Dose for Acute Lung Inflammation in Mice. Environ. Health Perspect. 2006, 114, 328–333. DOI: https://doi.org/10.1289/ehp.8266.
- Schmid, O.; Stoeger, T. Surface Area is the Biologically Most Effective Dose Metric for Acute Nanoparticle Toxicity in the Lung. J. Aerosol Sci. 2016, 99, 133–143. DOI: https://doi.org/10.1016/j.jaerosci.2015.12.006.
- Hawley, B.; McKenna, D.; Marchese, A.; Volckens, J. Time Course of Bronchial Cell Inflammation following Exposure to Diesel Particulate Matter Using a Modified EAVES. Toxicol Vitro. 2014, 28, 829–837. DOI: https://doi.org/10.1016/j.tiv.2014.03.001.
- Hilton, G.; Barosova, H.; Petri-Fink, A.; Rothen-Rutishauser, B.; Bereman, M. Leveraging Proteomics to Compare Submerged versus Air-Liquid Interface Carbon Nanotube Exposure to a 3D Lung Cell Model. Toxicol Vitro. 2019, 54, 58–66. DOI: https://doi.org/10.1016/j.tiv.2018.09.010.
- Wang, G.; Zhang, X.; Liu, X.; Zheng, J. Co-Culture of Human Alveolar Epithelial (A549) and Macrophage (THP-1) Cells to Study the Potential Toxicity of Ambient PM2.5: A Comparison of Growth under ALI and Submerged Conditions. Toxicol Res. 2020, 9, 636–651. DOI: https://doi.org/10.1093/toxres/tfaa072.
- Blank, F.; Rothen-Rutishauser, B. M.; Schurch, S.; Gehr, P. An Optimized in Vitro Model of the Respiratory Tract Wall to Study Particle Cell Interactions. J Aerosol Med. 2006, 19, 392–405. DOI: https://doi.org/10.1089/jam.2006.19.392.