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Toxic & hazardous substance control

Multivariate biological profiling of the subacute effects of halogenated aliphatic hydrocarbons

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Pages 1123-1144 | Received 13 May 1992, Accepted 17 Jul 1992, Published online: 15 Dec 2008

References

  • Wahlström , B. 1988 . “ The need for new strategies ‐ the OECD existing chemicals program ” . In The Use of QSAR for Chemicals Screening ‐ Limitations and Possibilities , Report No. 8/1988 Stockholm, , Sweden : National Chemicals Inspectorate .
  • Hermens , J.L.M. 1989 . “ Quantitative structure‐activity relationships of environmental pollutants ” . In The Handbook of Environmental Chemistry. , Edited by: Hutzinger , O. Berlin : Springer Verlag .
  • Turner , L. , Choplin , F. , Dugard , P. , Hermens , J. , Jaeckh , R. , Marsmann , M. and Roberts , D. 1987 . Structure‐activity relationships in toxicology and eco‐toxicology: an assessment . Toxicology in Vitro , 1 : 143 – 171 .
  • Blum , D.J.W. and Speece , R.E. 1990 . Determining chemical toxicity to aquatic species . Environmental Science and Technology , 24 : 284 – 293 .
  • Wold , S. and Dunn , W.J. III . 1983 . Multivariate quantitative structure‐activity relationships (QSAR): Conditions for their applicability . Journal of Chemical Information and Computer Science , 23 : 6 – 13 .
  • Tosato , M.L. , Marchini , S. , Passerini , L. , Pino , A. , Eriksson , L. , Lindgren , F. , Hellberg , S. , Sjöström , M. , Skagerberg , B. and Wold , S. 1990 . QSARs based on statistical design and their use for identifying chemicals for further biological testing . Environmental Toxicology and Chemistry , 9 : 265 – 277 .
  • Jonsson , J. , Eriksson , L. , Sjöström , M. , Wold , S. and Tosato , M.L. 1989 . A strategy for ranking environmentally occurring chemicals . Chemometrics and Intelligent Laboratory Systems , 5 : 169 – 186 .
  • Eriksson , L. 1991 . A Strategy for Ranking Environmentally Occurring Chemicals. , Sweden : University of Umeå . PhD thesis
  • Dunn , WJ. III , Wold , S. , Edlund , U. , Hellberg , S. and Gasteiger , J. 1984 . Multivariate structure‐activity relationships between data from a battery of biological tests and an ensemble of structure descriptors: The PLS method . Quantitative Structure‐Activity Relationships , 3 : 131 – 137 .
  • Box , G.E.P , Hunter , W.G. and Hunter , J.S. 1978 . Statistics for Experimenters. , New York : Wiley .
  • Skagerberg , B. 1989 . Principal Properties in Design and Structural Description in QSAR. , Sweden : University of Umeâ . PhD thesis
  • Tosato , M.L. , Vigano , L. , Skagerberg , B. and Clementi , S. 1991 . A new strategy for ranking chemical hazards. Framework and application . Environmental Science and Technology , 25 : 695 – 702 .
  • Tysklind , M. , Lundgren , K. , Rappe , C. , Eriksson , L. , Jonsson , J. , Sjöström , M. and Ahlborg , U.G. 1992 . Multivariate characterization and modeling of polychlorinated dibenzo‐p‐dioxins and dibenzofurans . Environmental Science and Technology , 26 : 1023 – 1029 .
  • Tysklind , M. , Lundgren , K. , Rappe , C. , Eriksson , L. , Jonsson , J. and Sjöström , M. in press . Multivariate quantitative structure‐activity relationships for polychlorinated dibenzo‐p‐dioxins and dibenzofurans . Environmental Toxicology and Chemistry ,
  • M. Tysklind, B. van Bavel, P. Haglund, and C. Rappe. Multivariate characterization of polychlorinated biphenyls. Manuscript in preparation.
  • Eriksson , L. , Jonsson , J. , Hellberg , S. , Lindgren , F. , Skagerberg , B. , Wold , S. , Sjöström , M. and Berglind , R. 1990 . A strategy for ranking environmentally occurring Chemicals, Part III: Multivariate quantitative structure‐activity relationships for halogenated aliphatics . Environmental Toxicology and Chemistry , 9 : 1339 – 1351 .
  • Eriksson , L. , Jonsson , J. , Hellberg , S. , Lindgren , F. , Sjöström , M. , Wold , S. , Sandström , B.E. and Svensson , I. 1991 . A strategy for ranking environmentally occurring chemicals. Part V: The development of two genotoxicity QSARs for halogenated aliphatics . Environmental Toxicology and Chemistry , 10 : 585 – 596 .
  • Eriksson , L. , Hellberg , S. , Johansson , E. , Jonsson , J. , Sjöström , M. , Wold , S. , Berglind , R. and Karlsson , B. 1991 . A strategy for ranking environmentally occurring chemicals. Part VI: QSARs for the mutagenic effects of halogenated aliphatics . Acta Chemica Scandinavica , 45 : 935 – 944 .
  • NBC‐National Defence Research Establishment . 1992 . Subacute toxicity of 10 halogenated alkanes in albino rat. , Report 803:4 Umeå, , Sweden
  • Organization for Economic Cooperation and Development . 1987 . Repeated Dose Oral Toxicity ‐ Rodent: 28/14 day. , OECD guidelines for testing of chemicals, No. 407
  • Jolliffe , I.T. 1986 . Principal Component Analysis. , Berlin : Springer Verlag .
  • Wold , S. , Albano , C. , Dunn , W.J. III , Edlund , U. , Esbensen , K. , Geladi , P. , Hellberg , S. , Johansson , E. , Lindberg , W. and Sjöström , M. 1984 . “ Multivariate data analysis in chemistry ” . In Chemometrics ‐ Mathematics and Statistics in Chemistry. , Edited by: Kowalski , B. Dordrecht : Reidel .
  • Eriksson , L. , Sjöström , M. and Wold , S. 1992 . Rational ranking of chemicals according to environmental risk: An illustration using multivariate biological profiling of halogenated aliphatic hydrocarbons . Chemometrics and Intelligent Laboratory Systems , 14 : 245 – 252 .
  • Wold , S. 1978 . Cross‐validatory estimation of the number of components in factor and principal components analysis . Technometrics , 20 : 397 – 405 .
  • 1990 . Documentation of the Threshold Limit Values and Biological Exposure Indices. , 5th edition , Cincinnati, OH : American Conference of Governmental Industrial Hygienists (ACGIH), Inc. .

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