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Original Articles

NEPHROTOXICITY INDUCED BY C- AND N-ARYLSUCCINIMIDES

Pages 399-416 | Published online: 12 Aug 2010

REFERENCES

  • Ahmed , S. , Smith , J. H. , Nicholls , P. J. , Whomsley , R. and Cariuk , P. 1995 . Synthesis and evaluation of novel pyrrolidine-2,5-dione inhibitors as potential anti-tumor agents . Drug Des. Discovery , 12 : 275 – 287 .
  • Aleo , M. D. , Rankin , G. O. , Cross , T. J. and Schnellmann , R. G. 1991 . Toxicity of N-(3,5-dichlorophenyl)succinimide and metabolites to rat renal proximal tubules and mitochondria . Chem. Biol. Interact. , 78 : 109 – 121 .
  • Anders , M. W. 1980 . Metabolism of drugs by the kidney . Kidney Int. , 18 : 636 – 647 .
  • Anthony , M. L. , Gartland , K. P. R. , Beddell , C. R. , Lindon , J. C. and Nicholson , J. K. 1992 . Cephaloridine-induced nephrotoxicity in the Fischer 344 rat: Proton NMR spectroscopic studies of urine and plasma in relation to conventional clinical chemical and histopathological assessments of nephronal damage . Arch. Toxicol. , 66 : 525 – 537 .
  • Arjmand , M. and Sandermann , H. Jr. 1987 . N-(Chlorophenyl)succinimides: A novel metabolite class isolated from Phanerochaete chrysosporium . Pestic. Biochem. Physiol. , 27 : 173 – 181 .
  • Barrett , M. C. , Cashman , S. J. and Moss , J. 1983 . Experimental interstitial nephritis induced by N-(3,5-dichlorophenyl)succinimide . Br. J. Exp. Pathol. , 64 : 425 – 436 .
  • Beers , K. W. and Rankin , G. O. 1993 . Effect of N-(3,5-dichlorophenyl)-2-hydroxysuccinimide on renal function and hemodynamics in the anesthetized rat . Toxicology , 79 : 139 – 148 .
  • Browne , T. R. , Feldman , R. G. , Buchanan , R. A. , Allen , N. C. , Fawcett-Vickers , L. , Szabo , G. K. , Mattson , G. F. , Norman , S. E. and Greenblatt , D. J. 1983 . Methsuximide for complex partial seizures: Efficacy, toxicity, clinical pharmacology, and drug interactions . Neurology , 33 : 414 – 418 .
  • Carter , C. H. 1954 . Use of Milontin in the control of petit mal epilepsy . Neurology , 4 : 935 – 937 .
  • Chakrabarti , S. K. and Tuchweber , B. 1988 . Studies of acute nephrotoxic potential of trichloroethylene in Fischer 344 rats . J. Toxicol. Environ. Health A , 23 : 147 – 158 .
  • Chein , C. C. , Hung , Y. C. and Chu , C. L. 1972 . Greenhouse study and field experimentation on the control of sheath blight of rice with systemic fungicides . Yeh Yen Chiu , 21 : 191 – 202 .
  • Chen , G. , Weston , K. and Bratton , A. C. Jr. 1963 . Anticonvulsant activity and toxicity of phensuximide, methsuximide and ethosuximide . Epilepsia , 4 : 66 – 76 .
  • Chen , G. , Baron , J. and Duffel , M. W. 1995 . Enzyme- and sex-specific differences in the intralobular localizations and distributions of aryl sulfotransferase IV (tyrosine-ester sulfotransferase) and alcohol (hydroxysteroid) sulfotransferase A in rat liver . Drug Metab. Dispos. , 23 : 1346 – 1353 .
  • Cui , C. D. and Harvison , P. J. 1999 . Evidence for the formation of Phase II metabolites of N-(3,5-dichlorophenyl)succinimide (NDPS) in rats . Toxicologist , 48 : 29
  • Dahm , L. J. and Roth , R. A. 1991 . Protection against α-naphthyl isothiocyanate-induced liver injury by decreased hepatic non-protein sulfhydryl content . Biochem. Pharmacol. , 42 : 1181 – 1188 .
  • Davis , M. E. 1988 . Effects of AT-125 on the nephrotoxicity of hexachloro-1,3-butadiene in rats . Toxicol. Appl. Pharmacol. , 95 : 44 – 52 .
  • Dulude , H. , Salvador , R. and Gallant , G. 1995 . Synthesis and anti-HIV activity of new urea and nitrosourea derivatives of diamino acids . Bioorg. Med. Chem. , 3 : 151 – 160 .
  • Ellenhorn , M. J. and Barceloux , D. G. 1988 . Medical toxicology: Diagnosis and treatment of human poisoning , 229 – 266 . New York : Elsevier .
  • Ferrendelli , J. A. and Kupferberg , H. J. 1980 . “ Antiepileptic drugs: Succinimides ” . In In Antiepileptic drugs: Mechanisms of action , Edited by: Glaser , G. H. , Pentry , J. K. and Woodbury , D. M. 587 – 596 . New York : Raven Press .
  • Fowler , L. M. , Foster , J. R. and Lock , E. A. 1993 . Effect of ascorbic acid, acivicin and probenecid on the nephrotoxicity of 4-aminophneol in the Fischer 344 rat . Arch. Toxicol. , 67 : 613 – 621 .
  • Fujinami , A. , Ozaki , T. , Nodera , K. and Tanaka , K. 1972 . Studies on biological activity of cyclic imide compounds. Part. II. Antimicrobial activity of 1-phenylpyrrolidine-2,5-diones and related compounds . Agric. Biol. Chem. , 36 : 318 – 323 .
  • Goehring , R. R. , Greenwood , T. D. , Pisipati , J. S. and Wolfe , J. F. 1991 . Synthesis and anticonvulsant evaluation of some new 2-benzylsuccinimides . J. Pharm. Sci. , 80 : 790 – 792 .
  • Harvison , P. J. , Griffin , R. J. , Teets , V. J. , Nicoll , D. W. , Brown , P. I. and Rankin , G. O. 1992 . Nephrotoxic potential of N-(3,5-dichloro-4-hydroxypheny)succinimide and N-(3,5-dichlorophenyl-4-hydroxyphenyl)succinamic acid in Fischer 344 rats . Toxicol. Lett. , 60 : 221 – 226 .
  • Heaton , J. B. 1980 . Control of brown rot and transit rot of peaches with post-harvest fungicidal dips . Queens. J. Agric. Anim. Sci. , 37 : 155 – 159 .
  • Henesey , C. M. and Harvison , P. J. 1995 . Potential metabolism and cytotoxicity of N-(3,5-dichlorophenyl)succinimide and its hepatic metabolites in isolated rat renal cortical tubule cells . Toxicology , 104 : 9 – 16 .
  • Henesey , C. M. and Harvison , P. J. 2002 . Renal damage, metabolism and covalent binding following administration of the nephrotoxicant N-(3,5-dichlorophenyl)succinimide (NDPS) to male Fischer 344 rat . Toxicology , 170 : 187 – 200 .
  • Henesey , C. M. , Kellner-Weibel , G. L. , Tarloff , J. B. and Harvison , P. J. 1999 . Comparative disposition of the nephrotoxicant N(3,5dichlorophenyl)succinimide and the non-nephrotoxicant N-(3,5-difluorophenyl)succinimide in Fischer 344 rats . Drug Dispos. Metab. , 27 : 674 – 680 .
  • Hobbs , D. W. , Gould , N. P. , Hoffman , J. B. , Clineschmidt , B. V. , Pettibone , D. J. , Veber , D. F. and Freidinger , R. M. 1995 . Nonpeptide oxytocin antagonists: Identification and synthesis of a potent camphor aminosuccinimide . Bioorg. Med. Chem. Lett. , 5 : 119 – 122 .
  • Hong , S. K. , Anestis , D. K. , Ball , J. G. , Valentovic , M. A. and Rankin , G. O. 1997 . A role for leukotrienes in N-(3,5-dichlorophenyl) succinimide (NDPS) and NDPS metabolite nephrotoxicity in Fischer 344 rats . Toxicologist , 36 : 146
  • Hong , S. K. , Anestis , D. K. , Ball , J. G. , Valentovic , M. A. , Brown , P. I. and Rankin , G. O. 1999a. Sodium sulfate potentiates N-(3,5dichlorophenyl)-2-hydroxysuccinimide (NDHS) and N-(3,5-dichlorophenyl)-2-hydroxysuccinamic acid (2-NDHSA) nephrotoxicity in the Fischer 344 rat . Toxicology , 138 : 165 – 174 .
  • Hong , S. K. , Anestis , D. K. , Ball , J. G. , Valentovic , M. A. , Brown , P. I. and Rankin , G. O. 1999b . Effect of sulfation substrates/inhibitors on N-(3,5-dichlorophenyl)succinimide nephrotoxicity in Fischer 344 rats . J. Toxicol. Environ. Health A , 57 : 47 – 62 .
  • Hong , S. K. , Anestis , D. K. , Ball , J. G. , Valentovic , M. A. , Brown , P. I. and Rankin , G. O. 1999c . Effect of glucuronidation substrates/inhibitors on N-(3,5-dichlorophenyl)succinimide nephrotoxicity in the Fischer 344 rat . Toxicology , 132 : 43 – 55. .
  • Hong , S. K. , Anestis , D. K. , Skaggs , C. , Brown , P. I. and Rankin , G. O. 1999d . The role of glucuronidation in N-(3,5-dichlorophenyl) succinimide (NDPS) nephrotoxicity: Nephrotoxic potential of NDPS and NDPS metabolites in Gunn, Wistar and Fischer 344 rats . Toxicol. Appl. Pharmacol , 154 : 170 – 180. .
  • Huang , Z. , Qin , S. , Huang , Y. , Chen , P. , Huang , X. and Huang , J. 2000 . Composite agrochemicals for preventing and controlling plant diseases. People’s Rep. China Patent No. CN 1269140 . Chem. Abstr , 134 : 362775
  • Ito , N. , Sugihara , S. , Makiura , S. , Arai , M. , Hirao , K. , Denda , A. and Nishio , O. 1974 . Effect of N-(3,5-dichlorophenyl)succinimide on the histological pattern and incidence of kidney tumors in rats induced by dimethylnitrosoamine . Gann , 65 : 131 – 138 .
  • Jaklinski , A. and Bryc , R. 1975 . Microscopic examination of rat organs after administration of m-bromophenylsuccinimide for 6 and 14 weeks . Acta Polon. Pharm , 32 : 379 – 385 .
  • Jung , K. , Son , K. , Kim , M. , Lee , J. , Choi , J. , Lee , E. and Park , M. 1998 . The effect of N-alkyloxycarbonyl group on the anticonvulsant activities of N-alkyloxycarbonyl-alpha-amino-N-methylsuccinimides . Arch. Pharm. Res , 21 : 759 – 763 .
  • Kellner-Weibel , G. L. , Tchao , R. and Harvison , P. J. 1995 . Nephrotoxic potential of N-(3,5-dichlorophenyl)glutarimide and N-(3,5-dichlorophenyl)glutaric acid in Fischer 344 rats . Toxicol. Lett , 80 : 123 – 129 .
  • Kellner-Weibel , G. L. , Nyarko , A. K. , Tchao , R. , Henesey , C. M. and Harvison , P. J. 1997 . The effect of aromatic fluorine substitution on the nephrotoxicity and metabolism of N-(3,5-dichlorophenyl)succinimide in Fischer 344 rats . Toxicology , 117 : 73 – 83 .
  • Korinthenberg , R. , Wehrle , L. and Zimmerhackl , L. B. 1994 . Renal tubular dysfunction following treatment with anti-epileptic drugs . Eur. J. Pediatr , 153 : 855 – 858 .
  • Kuo , C.-H. , Braselton , W. E. and Hook , J. B. 1982 . Effect of phenobarbital on cephaloridine toxicity and accumulation in rabbit and rat kidneys . Toxicol. Appl. Pharmacol , 64 : 244 – 254 .
  • Kurono , M. , Fujiwari , I. and Yoshida , K. 2001 . Stereospecific interaction of a novel spirosuccinimide type aldose reductase inhibitor, AS3201, with aldose reductase . Biochemistry , 40 : 8216 – 8226 .
  • McNamara , J. O. 2001 . “ Drugs effective in the therapy of the epilepsies ” . In In The pharmacological basis of therapeutics , 10th ed. , Edited by: Hardman , J. , Limbird , L. E. and Gilman , A. G. 521 – 547 . New York : McGraw-Hill .
  • Millichap , J. G. 1952 . Milontin: A new drug in the treatment of petit mal . Lancet , 2 : 907 – 910 .
  • Nyarko , A. K. and Harvison , P. J. 1995 . Metabolism of the nephrotoxicant N-(3,5-dichlorophenyl)succinimide by isolated rat hepatocytes . Drug Metab. Dispos , 23 : 107 – 112 .
  • Ohkawa , H. , Hisada , Y. , Fujiwara , N. and Miyamato , J. 1974 . Metabolism of N-(3’,5’-dichlorophenyl)succinimide in rats and dogs . Agric. Biol. Chem , 38 : 1359 – 1369 .
  • Okuda , H. , Nojima , H. , Watanabe , N. and Watanabe , T. 1989 . Sulphotransferase-mediated activation of the carcinogen 5hydroxymethylchrysene. Species and sex differences in tissue distribution of the enzyme activity and a possible participation of hydroxysteroid sulphotransferases . Biochem. Pharmacol , 38 : 3003 – 3009. .
  • Omiecinski , C. J. , Remmel , R. P. and Hosagrahara , V. P. 1999 . Concise review of the cytochrome P450s and their roles in toxicology . Toxicol. Sci. , 48 : 151 – 156. .
  • Orton , T. C. and Nicholls , P. J. 1972 . Effects in rats of subacute administration of ethosuximide, methsuximide and phensuximide on hepatic microsomal enzymes and porphyrin turnover . Biochem. Pharmacol , 21 : 2253 – 2261. .
  • Prakash , C. and Cui , D. 1997 . Metabolism and excretion of a new antianxiety drug candidate, CP-93,393, in cynomolgus monkeys: Identification of the novel pyrimidine ring cleaved metabolites . Drug Metab. Dispos , 25 : 1395 – 1406. .
  • Prakash , C. , Cui , C. , Baxter , J. G. , Bright , G. M. , Miceli , J. and Wilner , K. 1998 . Metabolism and excretion of a new anxiolytic drug candidate, CP-93,393, in healthy male volunteers . Drug Metab. Dispos , 26 : 448 – 456. .
  • Rall , T. W. and Schleifer , L. S. 1985 . “ Drugs effective in the therapy of the epilepsies ” . In In The pharmacological basis of therapeutics , 7th ed , Edited by: Gilman , A. G. , Goodman , L. S. , Rall , T. W. and Murad , F. 446 – 472 . New York : Macmillan .
  • Rankin , G. O. 1982 . Nephrotoxicity following acute administration of N-(3,5-dichlorophenyl)succinimide in rats . Toxicology , 23 : 21 – 31. .
  • Rankin , G. O. 1997 . “ Succinimides ” . In In Comprehensive toxicology, Vol. 7, Renal toxicology , Edited by: Sipes , I. G. , McQueen , C. A. , Gandolfi , A. J. and Goldstein , R. S. 665 – 675 . Oxford : Elsevier Scientific .
  • Rankin , G. O. , Anestis , D. K. , Sun , H. , Crislip , T. W. , Casto , A. S. , Ball , J. G. and Valentovic , M. A. 2002 . Nephrotoxic effects of the R and S-enantiomers of N-(3,5-dichlorophenyl)-2-hydroxysuccinimde (NDHS) and its sulfate conjugate . Toxicologist , 66 : 81.
  • Rankin , G. O. , Beers , K. W. , Nicoll , D. W. , Anestis , D. K. , Shih , H. C. , Brown , P. I. and Hubbard , J. L. 1992a. Role of para-hydroxylation in phensuximide-induced urotoxicity in the Fischer 344 rat . Toxicology , 74 : 77 – 88. .
  • Rankin , G. O. , Beers , K. W. , Teets , V. J. , Nicoll , D. W. , Anestis , D. K. , Brown , P. I. and Wang , R. T. 1994 . Acute N-(3,5-dichlorophenyl) succinimide nephrotoxicity in female Fischer 344 rats . Toxicology , 88 : 151 – 164. .
  • Rankin , G. O. , Cressey-Veneziano , K. and Brown , P. I. 1984 . Onset of and recovery from acute N-(3,5-dichlorophenyl)succinimide-induced nephrotoxicity in Sprague-Dawley rats . Toxicology , 30 : 205 – 216. .
  • Rankin , G. O. , Cressey-Veneziano , K. , Wang , R.-T. and Brown , P. I. 1986a. Urinary tract effects of phensuximide in the Sprague-Dawley and Fischer 344 rat . J. Appl. Toxicol , 6 : 349 – 356. .
  • Rankin , G. O. , Hong , S. K. , Anestis , D. K. , Lash , L. H. and Miles , S. L. 2001a. In vitro nephrotoxicity induced by N-(3,5-dichlorophenyl) succinimide (NDPS) metabolites in isolated renal cortical cells from male and female Fischer 344 rats. Evidence for a nephrotoxic sulfate conjugate metabolite . Toxicology , 163 : 73 – 82. .
  • Rankin , G. O. , Hong , S. K. , Dial , L. D. and Anestis , D. K. 1996 . Effects of chloramphenicol, dehydroepiandrosterone (DHEA) and 2,6-dichloro-4-nitrophenol (DCNP) on N-(3,5-dichlorophenyl)-2-hydroxysuccinimide (NDHS) nephrotoxicity . Toxicologist , 30 : 303.
  • Rankin , G. O. , Hong , S. K. , Valentovic , M. A. , Beers , K. W. , Anestis , D. K. , Nicoll , D. W. , Ball , J. G. and Brown , P. I. 1997 . Effects of sodium sulfate on acute N-(3,5-dichlorophenyl)succinimide (NDPS) nephrotoxicity in the Fischer 344 rat . Toxicology , 123 : 1 – 13. .
  • Rankin , G. O. , Shih , H. C. , Teets , V. J. , Nicoll , D. W. and Brown , P. I. 1989 . Acute nephrotoxicity induced by N-(3,5-dichlorophenyl)-3hydroxysuccinamic acid in Fischer 344 rats . Toxicol. Lett , 48 : 217 – 223. .
  • Rankin , G. O. , Shih , H. C. , Teets , V. J. , Nicoll , D. W. and Brown , P. I. 1990a. Acute toxicity induced by 2-aryl-N-methylsuccinimides . J. Appl. Toxicol , 10 : 143 – 152. .
  • Rankin , G. O. , Shih , H. C. , Teets , V. J. , Yang , D. J. , Nicoll , D. W. and Brown , P. I. 1991a. N-(3,5-Dichlorophenyl)succinimide nephrotoxicity: Evidence against the formation of nephrotoxic glutathione or cysteine conjugates . Toxicology , 68 : 307 – 325. .
  • Rankin , G. O. , Shih , H. C. , Yang , D. J. , Richmond , C. D. , Teets , V. J. and Brown , P. I. 1988 . Nephrotoxicity of N-(3,5-dichlorophenyl) succinimide metabolites in vivo and in vitro . Toxicol. Appl. Pharmacol , 96 : 405 – 416. .
  • Rankin , G. O. , Sun , H. , Anestis , D. K. , Noe , O. II. , Ball , J. G. , Valentovic , M. A. , Brown , P. I. and Hubbard , J. L. 2001b . Role of stereochemistry in N-(3,5-dichlorophenyl)-2-hydroxysuccinamic acid (2-NDHSA) nephrotoxicity . Toxicology , 168 : 241 – 250 .
  • Rankin , G. O. , Teets , V. J. , Nicoll , D. W. and Brown , P. I. 1990b. Acute effects of the antiepileptic succinimides on the urinary tract and potentiation of phensuximide-induced urotoxicity by phenobarbital . J. Appl. Toxicol , 10 : 203 – 209. .
  • Rankin , G. O. , Teets , V. J. , Nicoll , D. W. and Brown , P. I. 1990c. Effect of buthionine sulfoximine on acute N-(3,5-dichlorophenyl) succinimide-induced nephrotoxicity in Fischer 344 rats . Toxicol. Lett , 52 : 91 – 100. .
  • Rankin , G. O. , Teets , V. J. , Nicoll , D. W. and Brown , P. I. 1991b. Effect of buthionine sulfoximine on N-(3,5-dichlorophenyl)-2-hydroxysuccinimide and N-(3,5-dichlorophenyl)-2-hydroxysuccinamic acid nephrotoxicity . Toxicol. Lett , 57 : 297 – 308. .
  • Rankin , G. O. , Teets , V. J. , Shih , H. C. , Beers , K. W. , Nicoll , D. W. , Anestis , D. K. , Brown , P. I. and Hubbard , J. L. 1992b. Renal effects of N-(3,5-disubstituted phenyl)succinimides in the Fischer 344 rat . J. Appl. Toxicol , 12 : 211 – 216. .
  • Rankin , G. O. , Yang , D. J. , Cressey-Veneziano , K. and Brown , P. I. 1985a. N-(3,5-Dichlorophenyl)succinimide nephrotoxicity in the Fischer 344 rat . Toxicol. Lett , 24 : 99 – 105. .
  • Rankin , G. O. , Yang , D. J. , Lahoda , E. P. , Cressey-Veneziano , K. , Bailey , M. and Brown , P. I. 1985b. Acute nephrotoxicity of N-phenyl and N-(monochlorophenyl)succinimides in Fischer 344 and Sprague-Dawley rats . Toxicology , 34 : 299 – 308. .
  • Rankin , G. O. , Yang , D. J. , Richmond , C. D. , Teets , V. J. , Wang , R. T. and Brown , P. I. 1987a. . Effect of microsomal enzyme activity modulation on N-(3,5-dichlrophenyl)succinimide-induced nephrotoxicity . Toxicology , 45 : 269 – 289. .
  • Rankin , G. O. , Yang , D. J. , Shih , H. C. and Hubbard , J. L. 1993 . Synthesis and toxicity of C- and N-arylsuccinimides . Trends Heterocycl. Chem , 3 : 83 – 93. .
  • Rankin , G. O. , Yang , D. J. , Teets , V. J. , Lo , H. H. and Brown , P. I. 1986b. 3,5-Dichloroaniline-induced nephrotoxicity in the Sprague-Dawley rat . Toxicol. Lett , 30 : 173 – 179. .
  • Reid , W. D. 1973 . Mechanism of renal necrosis induced by bromobenzene and chlorobenzene . Exp. Mol. Pathol , 19 : 197 – 214. .
  • Shafiee , A. , Amanlou , M. , Farsam , H. , Dehpour , A. R. , Mir-Ershadi , F. and Mani , A. R. 1999 . Synthesis and pharmacological activity of thebaine-derived mu-opiod receptor agonists . Pharm. Acta. Helv , 73 : 251 – 254. .
  • Shi , Z. , Zhou , M. and Ye , Z. 2000 . Resistance mechanisms of Sclerotina sclerotiorum to dimetachlon . Nongyaoxue Xuebao 2:47–51.Chem. Abstr. , 135 : 119456.
  • Sigler , M. , Strassburg , H. M. and Boenigk , H. E. 2001 . Effective and safe but forgotten: methsuximide in intractable epilepsies in children . Seizure , 10 : 120 – 124. .
  • Smith , P. C. and Lui , J. H. 1995 . Covalent binding of suprofen to renal tissue of rat correlates with excretion of its acyl glucuronide . Xenobiotica , 25 : 531 – 540. .
  • Spahn-Langguth , H. and Benet , L. Z. 1992 . Acyl glucuronides revisited: Is the glucuronidation process a toxification as well as a detoxification mechanism? . Drug Metab. Rev. , 24 : 5 – 48. .
  • Sugihara , S. , Shinohara , Y. , Miyata , Y. , Inoue , K. and Ito , N. 1975 . Pathologic analysis of chemical nephritis in rats induced by N-(3,5-dichlorophenyl)succinimide . Lab. Invest , 33 : 219 – 230. .
  • Takayama , C. and Fujinami , A. 1979 . Quantitative structure activity relationships of antifungal N-phenylsuccinimides and N-phenyl-1,2-dimethylcyclopropanedicarboximides . Pestic. Biochem. Physiol , 12 : 163 – 171. .
  • Takeda , S. , Koizumi , F. and Takazakura , E. 1996 . Ethosuximide-induced lupus-like syndrome with renal involvement . Intern. Med , 35 : 587 – 591. .
  • Tiegs , G. and Wendel , A. 1988 . Leukotriene-mediated liver injury . Biochem Pharmacol , 37 : 2569 – 2573. .
  • Vamecq , J. , Bac , P. , Herrenknecht , C. , Maurois , P. , Delcourt , P. and Stables , J. P. 2000 . Synthesis and anticonvulsant and neurotoxic properties of substituted N-phenyl derivatives of the phthalimide pharmacophore . J. Med. Chem , 43 : 1311 – 1319. .
  • Wang , H. and Mao , S. 2001 . Fungicidal composition containing zinc cyclohexylcarboxylate and organic heterocyclic substance . People Rep. China Patent No. CN 1303596.Chem. Abstr. , 135 : 340470.
  • Yang , D. J. , Lahoda , E. P. , Brown , P. I. and Rankin , G. O. 1985a . Acute nephrotoxicity of isomeric N-(dichlorophenyl)succinimides in Sprague-Dawley and Fischer 344 rats . Fundam. Appl. Pharmacol , 5 : 1119 – 1127. .
  • Yang , D. J. , Lahoda , E. P. , Brown , P. I. and Rankin , G. O. 1985b. Structure–nephrotoxicity relationships for para-substituted N-phenylsuccinimides in Sprague-Dawley and Fischer 344 rats . Toxicology , 36 : 23 – 35. .
  • Yang , D. J. , Richmond , C. D. , Teets , V. J. , Brown , P. I. and Rankin , G. O. 1985c. Effect of succinimide ring modification on N-(3,5-dichlorophenyl)succinimide nephrotoxicity in Sprague-Dawley and Fischer 344 rats . Toxicology , 37 : 65 – 77. .
  • Yang , D. J. , Lahoda , E. P. , Brown , P. I. and Rankin , G. O. 1986 . Acute N-(3,4,5-trichlorophenyl)succinimide-induced nephrotoxicity in Sprague-Dawley and Fischer 344 rats . Toxicol. Lett , 31 : 219 – 228. .
  • Yang , D. J. , Brown , P. I. , Lo , H. H. , Teets , V. J. and Rankin , G. O. 1987a. Structure–nephrotoxicity relationships for meta-substituted N-phenylsuccinimides . J. Appl. Toxicol , 7 : 153 – 160. .
  • Yang , D. J. , Lo , H. H. , Teets , V. J. , Brown , P. I. and Rankin , G. O. 1987b. Nephrotoxicity of N-(3,5-dihalophenyl)succinimides in Fischer 344 rats . J. Toxicol. Environ. Health A , 20 : 333 – 346. .
  • Yang , D. J. , Teets , V. J. , Bolton , B. , Brown , P. I. and Rankin , G. O. 1987c. Role of glutathione in acute N-(3,5-dichlorophneyl)succinimide-induced nephrotoxicity in Sprague-Dawley and Fischer 344 rats . Toxicology , 45 : 25 – 44. .
  • Zimmerman , F. T. 1956 . Evaluation of N-methyl-A, A-methylphenylsuccinimide in the treatment of petit mal epilepsy . NY State J. Med , 1956 : 1460 – 1465 .

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