REVIEW OF STUDIES CONCERNING THE TUMORIGENICITY OF 2-BUTOXYETHANOL IN B6C3F1 MICE AND ITS RELEVANCE FOR HUMAN RISK ASSESSMENT

REFERENCES

• Boatman , R. J. and Knaak , J. B. 2001 . “ Ethers of ethylene glycol and derivatives ” . In Patty’s industrial hygiene and toxicology , 5th ed. , Edited by: Bingham , E. , Cohrssen , B. and Powell , C. H. 73 – 270 . New York : Wiley Interscience .
   Google Scholar
• Bus , J. S. and Popp , J. A. 1987 . Perspectives on the mechanism of action of splenic toxicity of aniline and structurally-related compounds . Food Chem. Toxicol , 25 : 619 – 626 .
   PubMed Web of Science ®Google Scholar
• Carpenter , C. P. , Pozzani , U. C. , Weil , C. S. , Nair , J. H. III , Keck , G. A. and Smyth , H. F. Jr. 1956 . The toxicity of butyl cellosolve solvent . AMA Arch. Ind. Health , 14 : 114 – 131 .
   PubMedGoogle Scholar
• Chiu , D. , Lubin , B. , Roelofsen , B. and van , DeenenL. L. 1981 . Sickled erythrocytes accelerate clotting in vitro: An effect of abnormal membrane lipid asymmetry . Blood , 58 : 398 – 401 .
   PubMed Web of Science ®Google Scholar
• Ciccoli , L. , Ferrali , M. , Rossi , V. , Signorini , C. , Allessandrini , C. and Comporti , M. 1999 . Hemolytic drugs and dapsone induce iron release in erythrocytes and increase the free iron pool in spleen and liver . Toxicol. Lett. , 110 : 57 – 66 .
   PubMed Web of Science ®Google Scholar
• Corley , R. A. , Bormett , G. A. and Ghanayem , B. I. 1994 . Physiologically based pharmacokinetics of 2-butoxyethanol and its major metabolite, 2-butoxyacetic acid, in rats and humans . Toxicol. Appl. Pharmacol. , 129 : 61 – 79 .
   PubMed Web of Science ®Google Scholar
• Cunningham , M. L. 2002 . A mouse is not a rat is not a human: Species differences exist . Toxicol. Sci. , 70 : 157 – 158 .
   PubMed Web of Science ®Google Scholar
• ECETOC . 2004 . The toxicology of glycol ethers and its relevance to man , Brussels, , Belgium : European Centre for Ecotoxicology and Toxicology of Chemicals . Technical Report No. 92
   Google Scholar
• Elliot , B. M. and Ashby , J. 1997 . Review of the genotoxicity of 2-butoxyethanol . Mutat. Res. , 387 : 89 – 96 .
   PubMed Web of Science ®Google Scholar
• Ghanayem , B. I. and Sullivan , C. A. 1993 . Assessment of the haemolytic activity of 2-butoxyethanol and its major metabolite, butoxyacetic acid, in various mammals including humans . Hum. Exp. Toxicol. , 12 : 305 – 311 .
   PubMed Web of Science ®Google Scholar
• Ghanayem , B. I. , Burka , L. T. and Matthews , H. B. 1987 . Metabolic basis of ethylene glycol monobutyl ether (2-butoxyethanol) toxicity: Role of alcohol and aldehyde dehydrogenases . J. Pharmacol. Exp. Ther. , 242 : 222 – 231 .
   PubMed Web of Science ®Google Scholar
• Ghanayem , B. I. , Sanchez , I. M. and Matthews , H. B. 1992 . Development of tolerance to 2-butoxyethanol-induced hemolytic anemia and studies to elucidate the underlying mechanisms . Toxicol. Appl. Pharmacol. , 112 : 198 – 206 .
   PubMed Web of Science ®Google Scholar
• Gingell , R. , Boatman , R. J. and Lewis , S. 1998 . Acute toxicity of ethylene glycol-n-butyl ether in the guinea pig . Food Chem. Toxicol. , 36 : 825 – 829 .
   PubMed Web of Science ®Google Scholar
• Gottschling , B. C. , Kamendulis , L. M. and Klaunig , J. E. 2000 . Modulation of focal and non-focal hepatocyte DNA synthesis in 2-butoxyethanol treated mice . Toxicologist , 54 (abst. 942)
   Google Scholar
• Green , T. , Toghill , A. , Lee , R. , Moore , R. and Foster , J. 2002 . The development of forestomach tumours in the mouse following exposure to 2-butoxyethanol by inhalation: Studies on the mode of action and relevance to humans . Toxicology , 180 : 257 – 273 .
   PubMed Web of Science ®Google Scholar
• Kamendulis , L. M. , Park , J. J. and Klaunig , J. E. 1999 . Potential mechanisms of rodent liver toxicity by 2-butoxyethanol: Oxidative stress studies , Indiana University . Toxicology Project No. 98-102, final report prepared for the Chemical Manufacturers Association (11 December)
   Google Scholar
• Khan , M. F. , Wu , X. , Alcock , N. W. , Boor , P. J. and Ansari , G. A. S. 1999 . Iron execerbates aniline-associated splenic toxicity . J. Toxicol. Environ. Health A , 57 : 173 – 184 .
   PubMed Web of Science ®Google Scholar
• Klaunig , J. E. and Kamendulis , L. M. 2004 . The role of oxidative stress in carcinogenesis . Annu. Rev. Pharmacol. Toxicol. , 44 : 239 – 67 .
   PubMed Web of Science ®Google Scholar
• Klaunig , J. E. , Xu , Y. , Isenberg , J. S. , Bachowski , S. , Ketchum , C. A. , Isenberg , J. S. , Kolaja , K. L. , Baker , T. K. , Walborg , E. F. Jr. and Stevenson , D. E. 1995 . Oxidative stress in nongenotoxic carcinogenesis . Toxicol. Lett. , 82–83 : 683 – 691 .
   PubMed Web of Science ®Google Scholar
• Klaunig , J. E. , Xu , Y. , Isenberg , J. S. , Bachowski , S. , Kolaja , K. L. , Jiang , J. , Stevenson , D. E. and Walborg , E. F. Jr. 1998 . The role of oxidative stress in chemical carcinogenesis . Environ. Health Perspect. , 106 ( suppl. 1 ) : 289 – 295 .
   PubMed Web of Science ®Google Scholar
• Kroes , R. and Wester , P. W. 1986 . Forestomach carcinogens: Possible mechanisms of action . Food Chem. Toxicol. , 24 : 1083 – 1089 .
   PubMed Web of Science ®Google Scholar
• LeBoeuf , R. A. , Kerckaert , G. A. , Aardema , M. J. , Gibson , D. P. , Brauninger , R. and Isfort , R. J. 1996 . The pH 6.7 Syrian hamster embryo cell transformation assay for assessing the carcinogenic potential of chemicals . Mutat. Res. , 356 : 85 – 107 .
   PubMed Web of Science ®Google Scholar
• National Toxicology Program . 1993 . Toxicology and carcinogenesis studies of p-nitroaniline (CAS No. 100-01-6) in B6C3F1 mice (gavage studies) , National Toxicology Program Technical Report Series No. 418 Research Triangle Park, NC : U.S. Department of Health and Human Services, Public Health Service, National Institutes of Health .
   Google Scholar
• National Toxicology Program . 2000 . Toxicology and carcinogenesis studies of 2-butoxyethanol (CAS No. 111-76-2) in F344/N rats and B6C3F₁ mice (inhalation studies) , National Toxicology Program Technical Report Series No. 484 Research Triangle Park, NC : U.S. Department of Health and Human Services, Public Health Service, National Institutes of Health .
   Google Scholar
• Omara , F. O. , Blakley , B. R. and Wanjala , L. S. 1993 . Hepatotoxicity associated with dietary iron overload in mice . Hum. Exp. Toxicol. , 12 : 463 – 467 .
   PubMed Web of Science ®Google Scholar
• Park , J. , Kamendulis , L. M. and Klaunig , J. E. 2002a . Effects of 2-butoxyethanol on hepatic oxidative damage . Toxicol. Lett. , 126 : 19 – 29 .
   PubMed Web of Science ®Google Scholar
• Park , J. , Kamendulis , L. M. and Klaunig , J. E. 2002b . Mechanisms of 2-butoxyethanol carcinogenicity: Studies on Syrian hamster embryo (SHE) cell transformation Toxicol. Sci. , 68 : 43 – 50 .
   Google Scholar
• Poet , T. S. , Soelberg , J. J. , Weitz , K. K. , Mast , T. J. , Miller , R. A. , Thrall , B. D. and Corley , R. A. 2003 . Mode of action and pharmacokinetics studies of 2-butoxyethanol in the mouse with emphasis on forestomach dosimetry . Toxicol. Sci , 71 : 176 – 189 .
   PubMed Web of Science ®Google Scholar
• Schroit , A. J. , Tanaka , Y. , Madsen , J. and Fidler , I. J. 1984 . The recognition of red blood cells by macrophages: Role of phosphatidylserine and possible implications of membrane phospholipid asymmetry . Biol. Cell , 51 : 227 – 238 .
   PubMed Web of Science ®Google Scholar
• Schroit , A. J. , Madsen , J. W. and Tanaka , Y. 1985 . In vivo recognition and clearance of red blood cells containing phosphatidylserine in their plasma membranes . J. Biol. Chem. , 260 : 5131 – 5138 .
   PubMed Web of Science ®Google Scholar
• Schwartz , R. S. , Tanaka , Y. , Fidler , I. J. , Chiu , D. T. , Lubin , B. and Schroit , A. J. 1985 . Increased adherence of sickled and phosphatidylserine-enriched human erythrocytes to cultured human peripheral blood monocytes . J. Clin. Invest. , 75 : 1965 – 1972 .
   PubMed Web of Science ®Google Scholar
• Siesky , A. M. , Gottschling , B. C. , Park , J. , Kamendulis , L. M. and Klaunig , J. E. 2001 . Modulation of hepatic cell proliferation and oxidative stress in 2-butoxyethanol treated mice . Toxicologist , 60 (abstr. 1367)
   Google Scholar
• Siesky , A. M. , Kamendulis , L. M. and Klaunig , J. E. 2002 . Hepatic effects of 2-butoxyethanol in rodents . Toxicol. Sci. , 70 : 252 – 260 .
   PubMed Web of Science ®Google Scholar
• Sivaroa , D. V. and Mehendale , H. M. 1995 . Butoxyethanol autoprotection is due to resilience of newly formed erythrocytes to hemolysis . Arch. Toxicol. , 69 : 526 – 532 .
   PubMed Web of Science ®Google Scholar
• Söhnlein , B. , Letzel , S. , Weltle , D. , Rudiger , H. W. and Angerer , J. 1993 . Occupational chronic exposure to organic solvents. XIV. Examinations concerning the evaluation of a limit value for 2-ethoxyethanol and 2-ethoxyethyl acetate and the genotoxic effects of these glycol ethers . Int. Arch. Occup. Environ. Health , 64 : 479 – 484 .
   PubMed Web of Science ®Google Scholar
• Tamirisa , A. , Udden , M. M. and Patton , C. S. 2002 . Annexin V binding and hemolysis of rat RBCs exposed to butoxyacetic acid . Blood , 100 : 7b suppl. 1, part 2
   Web of Science ®Google Scholar
• Udden , M. M. 1994 . Hemolysis and decreased deformability of erythrocytes exposed to butoxyacetic acid, a metabolite of 2-butoxyethanol: II. Resistance in red blood cells from humans with potential susceptibility . J. Appl. Toxicol , 14 : 97 – 102 .
   PubMed Web of Science ®Google Scholar
• Udden , M. M. 2000 . Rat erythrocyte morphological changes after gavage dosing with 2-butoxyethanol: A comparison within vitro effects of butoxyacetic acid on rat or human erythrocytes . J. Appl. Toxicol. , 20 : 381 – 387 .
   PubMed Web of Science ®Google Scholar
• Udden , M. M. 2002 . In vitro sub-hemolytic effects of butoxyacetic acid on human and rat erythrocytes . Toxicol. Sci. , 69 : 258 – 264 .
   PubMed Web of Science ®Google Scholar
• Udden , M. M. and Patton , C. S. 1994 . Hemolysis and decreased deformability of erythrocytes exposed to butoxyacetic acid, a metabolite of 2-butoxyethanol. I. Sensitivity in rats and resistance in normal humans . J. Appl. Toxicol. , 14 : 91 – 96 .
   PubMed Web of Science ®Google Scholar
• U.S. Environmental Protection Agency . 1999 . Toxicological review of ethylene glycol monobutyl ether (EGBE), CAS 111-76-2, in support of summary information on the Integrated Risk Information System (IRIS) , Washington, DC : U.S. Environmental Protection Agency . The most up-to-date version of this document is available electronically via the Internet at
   Google Scholar
• Wilkinson , C. F. and Killeen , J. C. 1996 . A mechanistic interpretation of the oncogenicity of chlorothalonil in rodents and an assessment of human relevance . Regul. Toxicol. Pharmacol. , 24 : 69 – 84 .
   PubMed Web of Science ®Google Scholar
• Xue , H. , Kamendulis , L. M. and Klaunig , J. E. 1999 . A potential mechanism for 2-butoxyethanol (2-BE) induced mouse liver neoplasia . Toxicologist , 48 (abst. 1084)
   Google Scholar