Adequacy and Consistency of Animal Studies to Evaluate the Neurotoxicity of Chronic Low-Level Manganese Exposure in Humans

REFERENCES

• Agency for Toxic Substances and Disease Registry . 2000 . Toxicological profile for manganese (update) , Atlanta, GA : U.S. Department of Health and Human Services .
   Google Scholar
• Ardeleanu , A. , Loranger , S. , Kennedy , G. , L'Espérance , G. and Zayed , Z. 1999 . Emission rates and physico-chemical characteristics of Mn particles emitted by vehicles using methylcyclopentadienly manganese tricarbonyl (MMT) as an octane improver . Water Air Soil Pollut. , 115 : 411 – 427 .
   Web of Science ®Google Scholar
• Arnich , N. , Cunat , L. , Lanhers , M. C. and Burnel , D. 2004 . Comparative in situ study of the intestinal absorption of aluminum, manganese, nickel, and lead in rats . Biol. Trace Elem. Res. , 99 : 157 – 171 .
   PubMed Web of Science ®Google Scholar
• Autissier , N. , Rochette , L. , Dumas , P. , Beley , A. , Loireau , A. and Bralet , J. 1982 . Dopamine and norepinephrine turnover in various regions of the rat brain after chronic manganese chloride administration . Toxicology , 24 : 175 – 182 .
   PubMed Web of Science ®Google Scholar
• Baldwin , M. , Mergler , D. , Larribe , F. , Belanger , S. , Tardif , R. , Bilodeau , L. and Hudnell , K. 1999 . Bioindicator and exposure data for a population based study of manganese . Neurotoxicology , 20 : 343 – 353 .
   PubMed Web of Science ®Google Scholar
• Beuter , A. , Edwards , R. , deGeoffroy , A. , Mergler , D. and Hudnell , K. 1999 . Quantification of neuromotor function for detection of the effects of manganese . Neurotoxicology , 20 : 355 – 366 .
   PubMed Web of Science ®Google Scholar
• Bird , E. D. , Anton , A. H. and Bullock , B. 1984 . The effect of manganese inhalation on basal ganglia dopamine concentrations in rhesus monkey . Neurotoxicology , 5 : 59 – 65 .
   PubMed Web of Science ®Google Scholar
• Blumberg, K., and Walsh, M. P. 2004. Status report concerning the use of MMT in gasoline. International Council on Clean Transportation http://www.healthandcleanair.org/mmt/icct.pdf
   Google Scholar
• Bonilla , E. 1978 . Increased GABA content in caudate nucleus of rats after chronic manganese chloride administration . J. Neurochem. , 31 : 551 – 552 .
   PubMed Web of Science ®Google Scholar
• Bonilla , E. 1984 . Chronic manganese intake induces changes in the motor activity of rats . Exp. Neurol. , 84 : 696 – 700 .
   PubMed Web of Science ®Google Scholar
• Bonilla , E. and Prasad , A. L. 1984 . Effects of chronic manganese intake on the levels of biogenic amines in rat brain regions . Neurobehav. Toxicol. Teratol. , 6 : 341 – 344 .
   PubMedGoogle Scholar
• Bonilla , E. , Arrieta , A. , Castro , F. , Davila , J. O. and Quiroz , I. 1994 . Manganese toxicity: free amino acids in the striatum and olfactory bulb of the mouse . Invest. Clin. , 35 : 175 – 181 .
   PubMedGoogle Scholar
• Bourne , H. G. 1975 . The rhesus monkey , Vol. I , New York : Academic Press . Anatomy and physiology
   Google Scholar
• Bowler , R. M. , Mergler , D. , Sassine , M. P. , Larribe , F. and Hudnell , K. 1999 . Neuropsychiatric effects of manganese on mood . Neurotoxicology , 20 : 367 – 378 .
   PubMed Web of Science ®Google Scholar
• Brenneman , K. A. , Wong , B. A. , Buccellato , M. A. , Costa , E. R. , Gross , E. A. and Dorman , D. C. 2000 . Direct olfactory transport of inhaled manganese (54MnCl2) to the rat brain: Toxicokinetic investigations in a unilateral nasal occlusion model . Toxicol. Appl. Pharmacol. , 169 : 238 – 248 .
   PubMed Web of Science ®Google Scholar
• Bull , R. J. 1978 . Parodoxical decrease in corpus striatal manganese concentrations with manganese load . Commun. Psychopharmacol. , 2 : 17 – 20 .
   PubMedGoogle Scholar
• Calabresi , P. , Ammassari-Teule , M. , Gubellini , P. , Sancesario , G. , Morello , M. , Centonze , D. , Marfia , G. A. , Saulle , E. , Passino , E. , Picconi , B. and Bernardi , G. 2001 . A synaptic mechanism underlying the behavioral abnormalities induced by manganese intoxication . Neurobiol. Dis. , 8 : 419 – 432 .
   PubMed Web of Science ®Google Scholar
• Calne , D. B. , Chu , N. S. , Huang , C. C. , Lu , C. S. and Olanow , W. 1994 . Manganism and idiopathic parkinsonism: Similarities and differences . Neurology , 44 : 1583 – 1586 .
   PubMed Web of Science ®Google Scholar
• Chandra , S. V. 1983 . Psychiatric illness due to manganese poisoning . Acta Psychiatr. Scand. Suppl , 303 : 49 – 54 .
   PubMedGoogle Scholar
• Chandra , S. V. and Shukla , G. S. 1981 . Concentrations of striatal catecholamines in rats given manganese chloride through drinking water . J. Neurochem. , 36 : 683 – 687 .
   PubMed Web of Science ®Google Scholar
• Chandra , S. V. , Shukla , G. S. , Srivastava , R. S. , Singh , H. and Gupta , V. P. 1981 . An exploratory study of manganese exposure to welders . Clin. Toxicol. , 18 : 407 – 416 .
   PubMed Web of Science ®Google Scholar
• Cotzias , G. C. , Miller , S. T. , Papavasiliou , P. S. and Tang , L. C. 1976 . Interactions between manganese and brain dopamine . Med. Clin. North Am. , 60 : 729 – 738 .
   PubMed Web of Science ®Google Scholar
• Couper , J. 1837 . On the effects of black oxide of manganese when inhaled into the lungs . Br. Ann. Med. Pharmacol. Vital Stat. Gen. Sci. , 1 : 41 – 42 .
   Google Scholar
• Davis , J. M. , Jarabek , A. M. , Mage , D. T. and Graham , J. A. 1998 . The EPA health risk assessment of methylcyclopentadienyl manganese tricarbonyl (MMT) . Risk Anal. , 18 : 57 – 70 .
   PubMed Web of Science ®Google Scholar
• Dorman , D. C. , Struve , M. F. , Arden , J. R. , Marshall , M. W. , Parkinson , C. U. and Wong , B. A. 2001 . Influence of particle solubility on the delivery of inhaled manganese to the rat brain: Manganese sulfate and manganese tetroxide pharmacokinetics following repeated (14 day) exposure . Tox. and App. Pharm. , 170 : 79 – 87 .
   PubMed Web of Science ®Google Scholar
• Dorman , D. C. , Brenneman , K. A. , McElveen , A. M. , Lynch , S. E. , Roberts , K. C. and Wong , B. A. 2002 . Olfactory transport: A direct route of delivery of inhaled manganese phosphate to the rat brain . J. Toxicol. Environ. Health A , 65 : 1493 – 1511 .
   PubMed Web of Science ®Google Scholar
• Dorman , D. C. , McManus , B. E. , Parkinson , C. U. , Manuel , C. A. , McElveen , A. M. and Everitt , J. I. 2004 . Nasal toxicity of manganese sulfate and manganese phosphate in young male rats following subchronic (13-week) inhalation exposure . Inhal. Toxicol. , 16 : 481 – 488 .
   PubMed Web of Science ®Google Scholar
• Dorman , D. C. , McElveen , A. M. , Marshall , M. W. , Parkinson , C. U. , James , R. A. , Struve , M. F. and Wong , B. A. 2005 . Tissue manganese concentrations in lactating rats and their offspring following combined in utero and lactation exposure to inhaled manganese sulfate . Toxicol. Sci. , 84 : 12 – 21 .
   PubMed Web of Science ®Google Scholar
• Egyed , M. and Wood , G. C. 1996 . Risk assessment for combustion products of the gasoline additive MMT in Canada . Sci. Total Environ. , 190 : 11 – 20 .
   Google Scholar
• Eriksson , H. , Lenngren , S. and Heilbronn , E. 1987a . Effect of long-term administration of manganese on biogenic amine levels in discrete striatal regions of rat brain . Arch. Toxicol. , 59 : 426 – 431 .
   PubMed Web of Science ®Google Scholar
• Eriksson , H. , Mägiste , K. , Plantin , L. O. , Fonnum , F. , Hedström , K. G. , Theodorsson-Norheim , E. , Kristensson , K. , Stålberg , E. and Heilbronn , E. 1987b . Effects of manganese oxide on monkeys as revealed by a combined neurochemical, histological and neurophysiological evaluation . Arch. Toxicol. , 61 : 46 – 52 .
   PubMed Web of Science ®Google Scholar
• Eriksson , H , Gillberg , P. G. , Aquilonius , S. M. , Hedstrom , K. G. and Heilbronn , E. 1992a . Receptor alterations in manganese intoxicated monkeys . Arch. Toxicol , 66 : 359 – 364 .
   PubMed Web of Science ®Google Scholar
• Eriksson , H. , Tedroff , J. , Thuomas , K. A. , Aquilonius , S. M. , Hartvig , P. , Fasth , K. J. , Bjurling , P. , Langstrom , B. , Hedstrom , K. G. and Heilbronn , E. 1992b . Manganese induced brain lesions in Macaca fascicularis as revealed by positron emission tomography and magnetic resonance imaging . Arch. Toxicol. , 66 : 403 – 407 .
   PubMed Web of Science ®Google Scholar
• Frumkin , H. and Solomon , G. 1997 . Manganese in the U.S. gasoline supply . Am. J. Ind. Med , 31 : 107 – 115 .
   PubMed Web of Science ®Google Scholar
• Gianutsos , G. and Murray , M. T. 1982 . Alterations in brain dopamine and GABA following inorganic or organic manganese administration . Neurotoxicology , 3 : 75 – 81 .
   PubMed Web of Science ®Google Scholar
• Gorell , J. M. , Johnson , C. C. , Rybicki , B. A. , Peterson , E. L. , Kortsha , G. X. , Brown , G. G. and Richardson , R. J. 1999 . Occupational exposure to manganese, copper, lead, iron, mercury and zinc and the risk of Parkinson's disease . Neurotoxicology , 20 : 239 – 247 .
   PubMed Web of Science ®Google Scholar
• Gupta , S. K. , Murthy , R. C. and Chandra , S. V. 1980 . Neuromelanin in manganese-exposed primates . Toxicol. Lett , 6 : 17 – 20 .
   PubMed Web of Science ®Google Scholar
• Gwiazda , R. H. , Lee , D. , Sheridan , J. and Smith , D. R. 2002 . Low cumulative manganese exposure affects striatal GABA but not dopamine . Neurotoxicology , 23 : 69 – 76 .
   PubMed Web of Science ®Google Scholar
• Henriksson , J. and Tjalve , H. 2000 . Manganese taken up into the CNS via the olfactory pathway in rats affects astrocytes . Toxicol. Sci. , 55 : 392 – 398 .
   PubMed Web of Science ®Google Scholar
• Huang , C. C. , Chu , N. S. , Lu , C. S. , Wang , J. D. , Tsai , J. L. , Tzeng , J. L. , Wolters , E. C. and Calne , D. B. 1989 . Chronic manganese intoxication . Arch. Neurol. , 46 : 1104 – 1106 .
   PubMed Web of Science ®Google Scholar
• Huang , C. C. , Lu , C. S. , Chu , N. S. , Hochberg , F. , Lilienfeld , D. , Olanow , W. and Calne , D. B. 1993 . Progression after chronic manganese exposure . Neurology , 43 : 1479 – 1483 .
   PubMed Web of Science ®Google Scholar
• Hudnell , H. K. 1999 . Effects from environmental Mn exposures: A review of the evidence from nonoccupational exposure studies . Neurotoxicology , 20 : 379 – 397 .
   PubMed Web of Science ®Google Scholar
• Iregren , A. 1990 . Psychological test performance in foundry workers exposed to low levels of manganese . Neurotoxicol. Teratol. , 12 : 673 – 675 .
   PubMed Web of Science ®Google Scholar
• Iregren , A. 1999 . Manganese neurotoxicity in industrial exposures: proof of effects, critical exposure level, and sensitive tests . Neurotoxicology , 20 : 315 – 323 .
   PubMed Web of Science ®Google Scholar
• Kennedy , G. and Valentine , R. 1994 . “ Inhalation Toxicology ” . In Principles and methods of toxicology , Edited by: Hayes , A. W. 805 – 838 . New York : Raven Press .
   Google Scholar
• Kim , E. , Kim , Y. , Cheong , H. K. , Cho , S. , Shin , Y. C. , Sakong , J. , Kim , K. S. , Yang , J. S. , Jin , Y. W. and Kang , S. K. 2005 . Pallidal index on MRI as a target organ dose of manganese: Structural equation model analysis . Neurotoxicology , 26 : 351 – 359 .
   PubMed Web of Science ®Google Scholar
• Koller , W. C. , Lyons , K. E. and Truly , W. 2004 . Effect of levodopa treatment for parkinsonism in welders: A double-blind study . Neurology , 62 : 730 – 733 .
   PubMed Web of Science ®Google Scholar
• Komura , J. and Sakamoto , M. 1992 . Effects of manganese forms on biogenic amines in the brain and behavioral alterations in the mouse—Long-term oral administration of several manganese compounds . Environ. Res. , 57 : 34 – 44 .
   PubMed Web of Science ®Google Scholar
• Kondakis , X. G. , Makris , N. , Leotsinidis , M. , Prinou , M. and Papapetropoulos , T. 1989 . Possible health effects of high manganese concentration in drinking water . Arch. Environ. Health , 44 : 175 – 178 .
   PubMed Web of Science ®Google Scholar
• Kosicka , B. , Bugera , T. E. , Czlonkowski , A. and Smialek , M. 1983 . [Effect of experimental manganese chloride poisoning on the gamma-aminobutyric acid (GABA) content and dopaminergic receptor D–2 of the rat brain. Preliminary report], in polish . Neuropatol. Pol. , 21 : 411 – 418 .
   PubMedGoogle Scholar
• Lewis , J. , Bench , G. , Myers , O. , Tinner , B. , Staines , W. , Barr , E. , Divine , K. K. , Barrington , W. and Karlsson , J. 2005 . Trigeminal uptake and clearance of inhaled manganese chloride in rats and mice . Neurotoxicology , 26 : 113 – 123 .
   PubMed Web of Science ®Google Scholar
• Lipe , G. W. , Duhart , H. , Newport , G. D. , Slikker , W. and Ali , S. F. 1999 . Effect of manganese on the concentration of amino acids in different regions of the rat brain . J. Environ. Sci. Health B Pestic. , 34 : 119 – 132 .
   PubMed Web of Science ®Google Scholar
• Lu , C. S. , Huang , C. C. , Chu , N. S. and Calne , D. B. 1994 . Levodopa failure in chronic manganism . Neurology , 44 : 1600 – 1602 .
   PubMed Web of Science ®Google Scholar
• Lucchini , R. , Selis , L. , Folli , D. , Apostoli , P. , Mutti , A. , Vanoni , O. , Iregren , A. and Alessio , L. 1995 . Neurobehavioral effects of manganese in workers from a ferroalloy plant after temporary cessation of exposure . Scand. J. Work Environ. Health , 21 : 143 – 149 .
   PubMed Web of Science ®Google Scholar
• Lucchini , R. , Apostoli , P. , Perrone , C. , Placidi , D. , Albini , E. , Migliorati , P. , Mergler , D. , Sassine , M. P. , Palmi , S. and Alessio , L. 1999 . Long term exposure to "low levels" of manganese oxides and neurofunctional changes in ferroalloy workers . Neurotoxicology , 20 : 287 – 297 .
   PubMed Web of Science ®Google Scholar
• Lucchini , R. , Benedetti , L. , Borghesi , S. , Garattini , S. , Parrinello , G. and Alessio , L. 2003 . Exposure to neurotoxic metals and prevalence of parkinsonian syndrome in the area of Brescia . G. Ital. Med. Lav. Ergon. , 25 ( suppl. ) : 88 – 89 .
   PubMedGoogle Scholar
• Lyznicki , J. M. , Karlan , M. S. and Khan , M. K. 1999 . Manganese in gasoline. Council on Scientific Affairs, American Medical Association . J. Occup. Environ. Med , 41 : 140 – 143 .
   PubMed Web of Science ®Google Scholar
• Mella , H. 1924 . The experimental production of basal ganglia symptomatology in macacus rhesus . Arch. Neurol. Psychiat , 11 : 405 – 417 .
   Google Scholar
• Mena , I. , Court , J. , Fuenzalida , S. , Papavasiliou , P. S. and Cotzias , G. C. 1970 . Modification of chronic manganese poisoning. Treatment with L-dopa or 5-OH tryptophan . N. Engl. J. Med. , 282 : 5 – 10 .
   PubMed Web of Science ®Google Scholar
• Mergler , D. 1999 . Neurotoxic effects of low level exposure to manganese in human populations . Environ. Res. , 80 : 99 – 102 .
   PubMed Web of Science ®Google Scholar
• Mergler , D. and Baldwin , M. 1997 . Early manifestations of manganese neurotoxicity in humans: An update . Environ. Res. , 73 : 92 – 100 .
   PubMed Web of Science ®Google Scholar
• Mergler , D. , Huel , G. , Bowler , R. , Iregren , A. , Belanger , S. , Baldwin , M. , Tardif , R. , Smargiassi , A. and Martin , L. 1994 . Nervous system dysfunction among workers with long-term exposure to manganese . Environ. Res. , 64 : 151 – 180 .
   PubMed Web of Science ®Google Scholar
• Mergler , D. , Baldwin , M. , Belanger , S. , Larribe , F. , Beuter , A. , Bowler , R. , Panisset , M. , Edwards , R. , de Geoffroy , A. , Sassine , M. P. and Hudnell , K. 1999 . Manganese neurotoxicity, a continuum of dysfunction: results from a community based study . Neurotoxicology , 20 : 327 – 342 .
   PubMed Web of Science ®Google Scholar
• Molders , N. , Schilling , P. J. , Wong , J. , Roos , J. W. and Smith , I. L. 2001 . X-ray fluorescence mapping and micro-XANES spectroscopic characterization of exhaust particulates emitted from auto engines burning MMT-added gasoline . Environ. Sci. Technol. , 35 : 3122 – 3129 .
   PubMed Web of Science ®Google Scholar
• Montes , S. , Alcaraz-Zubeldia , M. , Muriel , P. and Rios , C. 2001 . Striatal manganese accumulation induces changes in dopamine metabolism in the cirrhotic rat . Brain Res. , 891 : 123 – 129 .
   PubMed Web of Science ®Google Scholar
• Morganti , J. B. , Lown , B. A. , Stineman , C. H. , D'Agostino , R. B. and Massaro , E. J. 1985 . Uptake, distribution and behavioral effects of inhalation exposure to manganese (MnO2) in the adult mouse . Neurotoxicology , 6 : 1 – 15 .
   PubMed Web of Science ®Google Scholar
• Nachtman , J. P. , Tubben , R. E. and Commissaris , R. L. 1986 . Behavioral effects of chronic manganese administration in rats: Locomotor activity studies . Neurobehav. Toxicol. Teratol , 8 : 711 – 715 .
   PubMedGoogle Scholar
• Neff , N. H. , Barrett , R. E. and Costa , E. 1969 . Selective depletion of caudate nucleus dopamine and serotonin during chronic manganese dioxide administration to squirrel monkeys . Experientia , 25 : 1140 – 1141 .
   PubMedGoogle Scholar
• Newland , M. C. 1999 . Animal models of manganese's neurotoxicity . Neurotoxicology , 20 : 415 – 432 .
   PubMed Web of Science ®Google Scholar
• Newland , M. C. and Weiss , B. 1992 . Persistent effects of manganese on effortful responding and their relationship to manganese accumulation in the primate globus pallidus . Toxicol. Appl. Pharmacol. , 113 : 87 – 97 .
   PubMed Web of Science ®Google Scholar
• Newland , M. C. , Ceckler , T. L. , Kordower , J. H. and Weiss , B. 1989 . Visualizing manganese in the primate basal ganglia with magnetic resonance imaging . Exp. Neurol. , 106 : 251 – 258 .
   PubMed Web of Science ®Google Scholar
• Nishiyama , K. , Suzuki , Y. , Fujii , N. , Yano , H. , Ohnishi , K. and Miyai , T. 1977 . Biochemical changes and manganese distribution in monkeys exposed to manganese dioxide dust . Tokushima J. Exp. Med. , 24 : 137 – 145 .
   PubMedGoogle Scholar
• Normandin , L. , Ann Beaupre , L. , Salehi , F. , St-Pierre , A. , Kennedy , G. , Mergler , D. , Butterworth , R. .F , Philippe , S. and Zayed , J. 2004 . Manganese distribution in the brain and neurobehavioral changes following inhalation exposure of rats to three chemical forms of manganese . Neurotoxicology , 25 : 433 – 441 .
   PubMed Web of Science ®Google Scholar
• Normandin , L. , Carrier , G. , Gardiner , P. F. , Kennedy , G. , Hazell , A. S. , Mergler , D. , Butterworth , R. F. , Philippe , S. and Zayed , J. 2002 . Assessment of bioaccumulation, neuropathology, and neurobehavior following subchronic (90 days) inhalation in Sprague-Dawley rats exposed to manganese phosphate . Toxicol. Appl. Pharmacol. , 183 : 135 – 145 .
   PubMed Web of Science ®Google Scholar
• Olanow , C. W. , Good , P. F. , Shinotoh , H. , Hewitt , K. A. , Vingerhoets , F. , Snow , B. J. , Beal , M. F. , Calne , D. B. and Perl , D. P. 1996 . Manganese intoxication in the rhesus monkey—A clinical, imaging, pathologic, and biochemical study . Neurology , 46 : 492 – 498 .
   PubMed Web of Science ®Google Scholar
• Pentschew , A. , Ebner , F. F and Kovatch , R. M. 1963 . Experimental manganese encephalopathy in monkeys. A preliminary report . J. Neuropathol. Exp. Neurol , 22 : 488 – 499 .
   PubMed Web of Science ®Google Scholar
• Racette , B. A. , Tabbal , S. D. , Jennings , D. , Good , L. , Perlmutter , J. S. and Evanoff , B. 2005a . Prevalence of Parkinsonism and relationship to exposure in a large sample of Alabama welders . Neurology , 64 : 230 – 235 .
   PubMed Web of Science ®Google Scholar
• Racette , B. A. , Antenor , J. A. , McGee-Minnich , L. , Moerlein , S. M. , Videen , T. O. , Kotagal , V. and Perlmutter , J. S. 2005b . [18F]FDOPA PET and clinical features in Parkinsonism due to manganism . Mov. Disord. , 20 : 492 – 496 .
   PubMed Web of Science ®Google Scholar
• Ressler , T. , Wong , J. and Roos , J. 1999 . Manganese speciation in exhaust particulates of automobiles using MMT-containing gasoline . J. Synchrotron Radiat. , 6 : 656 – 658 .
   PubMed Web of Science ®Google Scholar
• Rodier , J. 1955 . Manganese poisoning in Moroccan miners . Br. J. Ind. Med. , 12 : 21 – 35 .
   PubMedGoogle Scholar
• Roels , H. , Lauwerys , R. , Genet , P. , Sarhan , M. J. , de Fays , M. , Hanotiau , I. and Buchet , J. P. 1987 . Relationship between external and internal parameters of exposure to manganese in workers from a manganese oxide and salt producing plant . Am. J. Ind. Med. , 11 : 297 – 305 .
   PubMed Web of Science ®Google Scholar
• Roels , H. , Meiers , G. , Delos , M. , Ortega , I. , Lauwerys , R. , Buchet , J. P. and Lison , D. 1997 . Influence of the route of administration and the chemical form (MnCl2, MnO2) on the absorption and cerebral distribution of manganese in rats . Arch. Toxicol. , 71 : 223 – 230 .
   PubMed Web of Science ®Google Scholar
• Roels , H. A. , Ghyselen , P. , Buchet , J. P , Ceulemans , E. and Lauwerys , R. R. 1992 . Assessment of the permissible exposure level to manganese in workers exposed to manganese dioxide dust . Br. J. Ind. Med. , 49 : 25 – 34 .
   PubMedGoogle Scholar
• Rollin , H. , Mathee , A. , Levin , J. , Theodorou , P. and Wewers , F. 2005 . Blood manganese concentrations among first-grade schoolchildren in two South African cities . Environ. Res. , 97 : 93 – 99 .
   PubMed Web of Science ®Google Scholar
• Rosenstock , H. A. , Simons , D. G. and Meyer , J. S. 1971 . Chronic manganism. Neurologic and laboratory studies during treatment with levodopa. J . Am. Med. Assoc. , 217 : 1354 – 1358 .
   PubMed Web of Science ®Google Scholar
• Salehi , F. , Krewski , D. , Mergler , D. , Normandin , L. , Kennedy , G. , Philippe , S. and Zayed , J. 2003 . Bioaccumulation and locomotor effects of manganese phosphate/sulfate mixture in Sprague-Dawley rats following subchronic (90 days) inhalation exposure . Toxicol. Appl. Pharmacol. , 191 : 264 – 271 .
   PubMed Web of Science ®Google Scholar
• Sharp , P. E. and LaRegina , M. C. 1998 . The laboratory rat , A volume in the laboratory animal pocket reference series. Boca Raton, FL : CRC Press .
   Google Scholar
• Shinotoh , H. , Snow , B. J. , Hewitt , K. A. , Pate , B. D. , Doudet , D. , Nugent , R. , Perl , D. P. , Olanow , W. and Calne , D. B. 1995 . MRI and PET studies of manganese-Iintoxicated monkeys . Neurology , 45 : 1199 – 1204 .
   PubMed Web of Science ®Google Scholar
• Shinotoh , H. , Snow , B. J. , Chu , N. S. , Huang , C. C. , Lu , C. S. , Lee , C. , Takahashi , H. and Caine , D. B. 1997 . Presynaptic and postsynaptic striatal dopaminergic function in patients with manganese intoxication: A positron emission tomography study . Neurology , 48 : 1053 – 1056 .
   PubMed Web of Science ®Google Scholar
• Shukla , G. S. and Chandra , S. V. 1981 . Striatal dopamine turnover and L-dopa treatment after short-term exposure of rats to manganese . Arch. Toxicol , 47 : 191 – 196 .
   PubMed Web of Science ®Google Scholar
• Spadoni , F. , Stefani , A. , Morello , M. , Lavaroni , F. , Giacomini , P. and Sancesario , G. 2000 . Selective vulnerability of pallidal neurons in the early phases of manganese intoxication . Exp. Brain Res. , 135 : 544 – 551 .
   PubMed Web of Science ®Google Scholar
• St-Pierre , A. , Normandin , L. , Carrier , G. , Kennedy , G. , Butterworth , R. and Zayed , J. 2001 . Bioaccumulation and locomotor effect of manganese dust in rats . Inhal. Toxicol. , 13 : 623 – 632 .
   PubMed Web of Science ®Google Scholar
• Subhash , M. N. and Padmashree , T. S. 1990 . Regional distribution of dopamine beta-hydroxylase and monoamine oxidase in the brains of rats exposed to manganese . Food Chem. Toxicol , 28 : 567 – 570 .
   PubMed Web of Science ®Google Scholar
• Subhash , M. N. and Padmashree , T. S. 1991 . Effect of manganese on biogenic amine metabolism in regions of the rat brain . Food Chem. Toxicol. , 29 : 579 – 582 .
   PubMed Web of Science ®Google Scholar
• Suzuki , Y. , Mouri , T. , Nishiyama , K. and Fujii , N. 1975 . Study of subacute toxicity of manganese dioxide in monkeys. Tokushima . J. Exp. Med. , 22 : 5 – 10 .
   Google Scholar
• Talavera , E. J. , Arcaya , J. L. , Giraldoth , D. , Suarez , J. and Bonilla , E. 1999 . Decrease in spontaneous motor activity and in brain lipid peroxidation in manganese and melatonin treated mice . Neurochem. Res. , 24 : 705 – 708 .
   PubMed Web of Science ®Google Scholar
• Tanaka , S. and Lieben , J. 1969 . Manganese poisoning and exposure in Pennsylvania . Arch. Environ. Health , 19 : 674 – 684 .
   PubMed Web of Science ®Google Scholar
• Tapin , D. , Kennedy , G. , Lambert , J. and Zayed , J. 2005 . Bioaccumulation and locomotor effects of manganese sulfate in Sprague-Dawley rats following subchronic (90 days) inhalation exposure . Toxicol. Appl. Pharmacol. , 211 : 166 – 174 .
   PubMed Web of Science ®Google Scholar
• Thibault , C. , Kennedy , G. , Gareau , L. and Zayed , J. 2002 . Preliminary assessment of atmospheric methylcyclopentadienyl manganese tricarbonyl and particulate manganese in selected urban sites . J. Toxicol. Environ. Health A , 65 : 503 – 511 .
   PubMed Web of Science ®Google Scholar
• Ulrich , C. E. , Monaco , R. A. and Messer , S. M. 1977 . Baseline pulmonary physiologic values for the squirrel monkey (Saimiri sciureus) . Lab. Anim. Sci , 27 : 1024 – 1027 .
   PubMedGoogle Scholar
• Ulrich , C. E. , Rinehart , W. and Brandt , M. 1979a . Evaluation of the chronic inhalation toxicity of a manganese oxide aerosol. III. Pulmonary function, electromyograms, limb tremor, and tissue manganese data . Am. Ind. Hyg. Assoc. J , 40 : 349 – 353 .
   PubMed Web of Science ®Google Scholar
• Ulrich , C. E. , Rinehart , W. and Busey , W. 1979b . Evaluation of the chronic inhalation toxicity of a manganese oxide aerosol—I. Introduction, experimental design, and aerosol generation methods . 40 : 238 – 244 .
   Google Scholar
• Ulrich , C. E. , Rinehart , W. , Busey , W. and Dorato , M. A. 1979c . Evaluation of the chronic inhalation toxocity of a manganese oxide aerosol. II. Clinical observations, hematology, clinical chemistry and histopathology . Am. Ind. Hyg. Assoc. J. , 40 : 322 – 329 .
   PubMed Web of Science ®Google Scholar
• U. S. Environmental Protection Agency . 2004 . An examination of EPA risk assessments and practices , Washington, DC : Office of the Science Advisor, U.S. Environmental Protection Agency . EPA/100/B-04/001
   Google Scholar
• Van Bogaert , L. and Dallemagne , M. J. 1946 . Approches experimentales des troubles nerveux du manganisme . Monatisshrift. Psychiat. Neurol. , 111/112 : 61 – 89 .
   Google Scholar
• Vitarella , D. , Wong , B. A. , Moss , O. R. and Dorman , D. C. 2000 . Pharmacokinetics of inhaled manganese phosphate in male Sprague-Dawley rats following subacute (14-day) exposure . Toxicol. Appl. Pharmacol , 163 : 279 – 285 .
   PubMed Web of Science ®Google Scholar
• Weast , R. C. , ed. 1985 . Handbook of chemistry and physics, , 65th , Boca Raton, FL : CRC Press .
   Google Scholar
• Weigand , E. , Kirchgessner , M. and Helbig , U. 1986 . True absorption and endogenous fecal excretion of manganese in relation to its dietary supply in growing rats . Biol. Trace Elem. Res. , 10 : 265 – 279 .
   PubMed Web of Science ®Google Scholar
• Witholt , R. , Gwiazda , R. H. and Smith , D. R. 2000 . The neurobehavioral effects of subchronic manganese exposure in the presence and absence of pre-Parkinsonism . Neurotoxicol. Teratol. , 22 : 851 – 861 .
   PubMed Web of Science ®Google Scholar
• Wood , G. C. and Egyed , M. 1994 . Risk assessment for the combustion products of methylcyclopentadienyl manganese tricarbonyl (MMT) in gasoline , Ottawa : Environmental Health Directorate, Health Canada .
   Google Scholar
• Zayed , J. 2001 . Use of MMT in Canadian gasoline: Health and environment issues . Am. J. Ind. Med. , 39 : 426 – 433 .
   PubMed Web of Science ®Google Scholar