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Original Articles

The Influence of Genetic Polymorphisms on Population Variability in Six Xenobiotic-Metabolizing Enzymes

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Pages 307-333 | Published online: 06 Oct 2009

REFERENCES

  • Agundez , J. , Ledesma , M. and Ladero , J. 1995 . Prevalence of CYP2D6 gene duplication and its repercussion on the oxidative phenotype in a white population . Clin. Pharmacol. Ther. , 57 : 265 – 269 .
  • Avard , D. and Joly , M. 2008 . Improved understanding of genetic and genomic influences on drug disposition and action: implications for children . Paediatr. Drugs , 10 : 275 – 278 .
  • Bernardini , S. , Hirvonen , A. , Pelin , K. and Norppa , H. 1998 . Induction of sister chromatid exchange by 1,2-epoxy-3-butene in cultured human lymphocytes: Influence of GSTT1 genotype . Carcinogenesis , 2 : 377 – 380 .
  • Bertilsson , L. , Lou , Y.-Q. , Du , Y.-L. , Liu , Y. , Kuang , T.-Y. , Liao , X.-M , Wang , K.-Y. , Reviriego , J. , Iselius , L. and Sjoquist , F. 1992 . Pronounced differences between native Chinese and Swedish populations in the polymorphic hydroxylations of debrisoquin and S-mephenytoin . Clin. Pharmacol. Ther. , 51 : 388 – 397 .
  • Blatter-Garin , M. , James , R. , Dussoix , P. , Blanche , H. , Passa , P. , Froguel , P. and Ruiz , J. 1997 . Paraoxonase polymorphism Met-Leu55 is associated with modified serum concentrations of the enzyme. A possible link between the paraoxonase gene and increased risk of cardiovascular disease in diabetes . J. Clin. Invest. , 99 : 62 – 66 .
  • Bois , F. Y. , Krowech , G. and Zeise , L. 1995 . Modeling human interindividual variability in metabolism and risk: The example of 4-aminobiphenyl . Risk Anal. , 15 : 205213
  • Bolt , H. M. and Thier , R. 2006 . Relevance of the deletion polymorphisms of the glutathione S-transferases GSTT1 and GSTM1 in pharmacology and toxicology . Curr. Drug Metab. , 7 : 613 – 628 .
  • Brophy , V. , Jarvik , G. , Richter , R. , Rozek , L. , Schellenberg , G. and Furlong , C. 2000 . Analysis of paraoxonase (PON1) L55M status requires both genotype and phenotype . Pharmacogenetics , 10 : 453 – 460 .
  • Bruhn , C. , Brockmöller , J. , Cascorbi , I. , Roots , I. and Borchert , H.-H. 1999 . Correlation between genotype and phenotype of the human arylamine N-acetyltransferase Type 1 (NAT1) . Biochem. Pharmacol. , 58 : 1759 – 1764 .
  • Bruning , T. , Lammert , M. , Kempkes , M. , Thier , R. , Golka , K. and Bolt , H. M. 1997 . Influence of polymorphisms of GSTM1 and GSTT1 for risk of renal cell cancer in workers with long-term high occupational exposure to trichloroethene . Arch. Toxicol. , 71 : 596 – 599 .
  • Carriere , V. , Berthou , F. , Baird , S. , Belloc , C. , Beaune , P. and de Waziers , I. 1996 . Human Cytochrome P450 2E1: From genotype to phenotype . Pharmacogenetics , 6 : 203 – 211 .
  • Cascorbi , I. 2006 . Genetic basis of toxic reactions to drugs and chemicals . Toxicol. Lett. , 162 : 16 – 28 .
  • Cascorbi , I. 2003 . Pharmacogenetics of cytochrome p4502D6: Genetic background and clinical implication . Eur. J. Clin. Invest. , 33 ( suppl. 2 ) : 17 – 22 .
  • Cascorbi , I. , Drakoulis , N. , Brockmöller , J. , Mauer , A. , Sperling , K. and Roots , I. 1995 . Arylamine N-acetyltransferase (NAT2) mutations and their allelic linkage in unrelated caucasian individuals: Correlation with phenotypic activity . Am. J. Hum. Genet. , 57 : 581 – 592 .
  • Chen , Y. C. , Peng , G. S. , Wang , M. F. , Tsao , T. P. and Yin , S. J. 2008 . Polymorphism of ethanol-metabolism genes and alcoholism: Correlation of allelic variations with the pharmacokinetic and pharmacodynamic consequences . Chem. Biol. Interact. , 10.1016/j.cbi.2008.10.029
  • Chen , J. , Kumar , M. , Chan , W. , Berkowitz , G. and Wetmur , J. G. 2003 . Increased influence of genetic variation on PON1 activity in neonates . Environ. Health Perspect. , 111 : 1403 – 1409 .
  • Christensen , P. M. , Gotzsche , P. C. and Brosen , K. 1997 . The sparteine/debrisoquine (CYP2D6) oxidation polymorphism and the risk of lung cancer: A meta-analysis . Eur. J. Clin. Pharmacol. , 51 : 389 – 393 .
  • Corley , R. A. , Mendrala , A. L. , Smith , F. A. , Staats , D. A. , Gargas , M. L. , Conolly , R. B. , Anderson , M. E. and Reitz , R. H. 1990 . Development of a physiologically based pharmacokinetic model for chloroform . Toxicol. Appl. Pharmacol. , 103 : 512 – 527 .
  • Costa , L. , Li , W. , Richter , R. , Shih , D. , Lusis , A. and Furlong , C. 1999 . The role of paraoxonase (PON1) in the detoxication of organophosphates and its human polymorphism . Chem. Biol. Interact. , 119–120 : 429 – 438 .
  • Costa , L. G. , Vitalone , A. , Cole , T. B. and Furlong , C. E. 2005 . Modulation of paraoxonase (PON1) activity . Biochem. Pharmacol. , 69 : 541 – 550 .
  • Dalen , P. , Dahl , J.-L. , Eichelbaum , M. , Bertilsson , L. and Wilkinson , G. R. 1999 . Disposition of debrisoquine in Caucasians with different CYP2D6-genotypes including those with multiple genes . Pharmacogenetics , 9 : 697 – 706 .
  • Davies , H. , Richter , R. , Keifer , M. , Broomfield , C. , Sowalla , J. and Furlong , C. 1996 . The effect of the human serum paraoxonase polymorphism is reversed with diazoxon, soma and sarin . Nat. Genet. , 14 : 334 – 336 .
  • DePalma , G. , Manini , P. , Mozzoni , P. , Andreoli , R. , Bergamaschi , E. , Cavazzini , S. , Franchini , I. and Mutti , A. 2001 . Polymorphism of xenobiotic-metabolizing enzymes and excretion of styrene-specific mercapturic acids . Chem. Res. Toxicol. , 14 : 1393 – 1400 .
  • Dong , H. , Haining , R. L. , Thummel , K. E. , Rettie , A. E. and Nelson , S. D. 2000 . Involvement of human cytochrome P450 2D6 in the bioactivation of acetaminophen . Drug Metab. Dispos. , 28 : 1397 – 1400 .
  • Eaton , D. 2000 . Biotransformation enzyme polymorphism and pesticide susceptibility . Neurotoxicology , 21 : 101 – 112 .
  • Eng , M. Y. , Luczak , S. E. and Wall , T. L. 2007 . ALDH2, ADH1B, and ADH1C genotypes in Asians: a literature review . Alcohol Res. Health , 30 : 22 – 27 .
  • El-Masri , H. A. , Bell , D. A. and Portier , C. J. 1999 . Effects of glutathione transferase theta polymorphism on the risk estimates of dichloromethane to humans . Toxicol. Appl. Pharmacol. , 158 : 221 – 230 .
  • Evans , W. E. and Relling , M. V. 1999 . Pharmacogenomics: translating functional genomics into rational therapeutics . Science , 286 : 487 – 491 .
  • Foster , P. , Blackburn , D. M. , Moore , R. B. and Lloyd , S. C. 1986 . Testicular toxicity of 2- methoxyacetaldehyde, a possible metabolite of ethylene glycol monomethyl ether in the rat . Toxicol. Lett. , 32 : 73 – 80 .
  • Furlong, C. E. 2002. Comments on genetic and developmental variability of sensitivity to chlorpyrifos/chlorpyrifos oxon exposure as modulated by plasma paraoxonase (PON1). Comments provided to U.S. EPA SAP on chlorpyrifos http://www.epa.gov/scipoly/sap/2002/june/chlorphyr.pdf
  • Furlong , C. , Li , W.-F. , Brophy , V. , Jarvik , P. , Richter , R. , Shih , D. , Lusis , A. and Costa , L. 2000 . The PON1 gene and detoxication . Neurotoxicology , 21 : 581 – 588 .
  • Gentry , P. R. , Hack , C. E. , Haber , L. , Maier , A. and Clewell , H. J. 2002 . An approach for the quantitative consideration of genetic polymorphism data in chemical risk assessment: examples with warfarin and parathion . Toxicol. Sci. , 70 : 120 – 139 .
  • Gilham , D. , Cairns , W. , Paine , M. , Modi , S. , Poulsom , R. , Roberts , G. and Wolf , C. 1997 . Metabolism of MPTP by cytochrome P4502D6 and the demonstration of 2D6 mRNA in human foetal and adult brain by in situ hybridization . Xenobiotica , 27 : 111 – 125 .
  • Ginsberg , G. , Smolenski , S. , Hattis , D. and Sonawane , B. 2002 . Population distribution of aldehyde dehydrogenase-2 genetic polymorphism: Implications for risk assessment . Regul. Toxicol. Pharmacol. , 36 : 297 – 309 .
  • Golka , K. , Schmidt , T. , Seidel , T. , Dietrich , H. , Roemer , H. C. , Lohlein , D. , Reckwitz , T. , Sokeland , J. , Weistenhofer , W. , Blaszkewicz , M. and Selinski , S. 2008 . The influence of polymorphisms of glutathione S-transferases M1 and M3 on the development of human urothelial cancer . J. Toxicol. Envoron. Health A , 71 : 881 – 886 .
  • Goode , E. L. , Ulrich , C. M. and Potter , J. D. 2002 . Polymorphisms in DNA repair genes and associations with cancer risk . Cancer Epidemiol. Biomarkers Prev. , 11 : 1513 – 1530 .
  • Grant , D. M. , Hughes , N. C. , Janezic , S. A. , Goodfellow , G. H. , Chen , H. J. , Gaedigk , A. , Yu , V. L. and Grewal , R. 1997 . Human acetyltransferase polymorphisms . Mutat. Res. , 376 : 61 – 70 .
  • Guengerich , F. , Kim , D. and Iwasaki , M. 1991 . Role of human cytochrome P-450IIE1 in the oxidation of many low molecular weight cancer suspects . Chem. Res. Toxicol. , 4 : 168 – 179 .
  • Haber , L. T. , Maier , A. , Gentry , P. R. , Clewell , H. J. and Dourson , M. L. 2002 . Genetic polymorphisms in assessing interindividual variability in delivered dose . Regul. Toxicol. Pharmacol. , 35 : 177 – 197 .
  • Hanoika , N. , Tanaka-Kagawa , T. , Miyata , Y. , Makino , Y. , Ohno , A. , Yoda , R. , Jinno , H. and Ando , M. 2003 . Functional characterization of three human cytochrome p450 2E1 variants with amino acid substitutions . Xenobiotica , 33 : 575 – 586 .
  • Hassett , C. , Aicher , L. , Sidhu , J. S. and Omiecinski , C. J. 1994 . Human microsomal epoxide hydrolase: Genetic polymorphism and functional expression in vitro of amino acid variants . Hum. Mol. Genet. , 3 : 421 – 428 .
  • Hattis , D. and Barlow , K. 1996 . Human interindividual variability. In Cancer Risks—Technical and Management Challenges . Hum. Ecol. Risk Assess. , 2 : 194 – 220 .
  • Hattis , D. , Banati , P. and Goble , R. 1999 . Distributions of individual susceptibility among humans for toxic effects: for what fraction of which kinds of chemicals and effects does the traditional 10-fold factor provide how much protection? . Ann. NY Acad. Sci. , 895 : 286 – 316 .
  • Hayes , J. D. , Flanagan , J. U. and Jowsey , I. R. 2005 . Glutathione transferases . Annu. Rev. Pharmacol. Toxicol. , 45 : 51 – 88 .
  • Hein , D. W. 2006 . N-Acetyltransferase 2 genetic polymorphism: Effects of carcinogen and haplotype on urinary bladder cancer risk . Oncogene , 25 : 1649 – 1658 .
  • Hein , D. W. , Doll , M. A. , Rustan , T. D. and Ferguson , R. J. 1995 . Metabolic activation of N-hydroxyarylamines and N-hydroxyarylamides by 16 recombinant human NAT2 allozymes: Effects of specific NAT2 nucleic acid substitutions . Cancer Res. , 55 : 3531 – 3536 .
  • Hein , D. W. , McQueen , C. A. , Grant , D. M. , Goodfellow , G. H. , Kadlubar , F. and Weber , W. W. 2000a . Pharmacogenetics of the arylamine N-acetyltransferases: A symposium in honor of Wendell W. Weber . Drug Metab. Dispos. , 28 : 1425 – 1432 .
  • Hein , D. W. , Doll , M. A. , Fretland , A. J. , Leff , M. A. , Webb , S. J. , Xiao , G. H. , Devanaboyina , U.-S. , Nangju , N. A. and Feng , Y. 2000b . Molecular genetics and epidemiology of the NAT1 and NAT2 acetylation polymorphisms . Cancer Epidemiol. Biomarkers Prev. , 9 : 29 – 42 .
  • Helzlsouer , K. , Selmin , O. , Huang , H. , Strickland , P. , Hoffman , S. , Alberg , A. , Watson , M. , Comstock , G. and Bell , D. 1998 . Association between glutathione S-transferase M1, P1, and T1 genetic polymorphisms and development of breast cancer . JNCI , 90 : 484 – 485 .
  • Hirvonen , A. and Pelkonen , O. 2001 . “ Measurement of drug metabolizing enzyme polymorphism as indicators of susceptibility ” . In Environmental health criteria: Biomarkers in risk assessment: Validity and validation , Vol. 222 , 146 – 201 . Geneva : WHO/IPCS .
  • Hu , X. , Herzog , C. , Zimniak , P. and Singh , S. V. 1999 . Differential protection against benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide-induced DNA damage in HepG2 cells stably transfected with allelic variants of π class human glutathione S-transferase . Cancer Res. , 59 : 2358 – 2362 .
  • Hughes , N. C. , Janezic , S. A. , McQueen , K. L. , Jewett , M. A. S. , Castranio , T. , Bell , D. A. and Grant , D. M. 1998 . Identification and characterization of variant alleles of human acetyltransferase NAT1 with defective function using p-aminosalicylate as an in-vivo and in-vitro probe . Pharmacogenetics , 8 : 55 – 66 .
  • Ingelman-Sundberg , M. 1998 . Functional consequences of polymorphism of xenobiotic metabolizing enzymes . Toxicol. Lett. , 102–103 : 155 – 160 .
  • Ingelman-Sundberg , M. 2005 . Genetic polymorphisms of cytochrome P450 2D6 (CYP2D6): Clinical consequences, evolutionary aspects and functional diversity . Pharmacogenom. J. , 5 : 6 – 13 .
  • International Programme on Chemical Safety . 2005 . “ Chemical-specific adjustment factors for interspecies differences and human variability: Guidance document for use of data in dose/concentration-response assessment ” . In Harmonization Project Document No. 2 , Geneva, Switzerland : World Health Organization, International Programme on Chemical Safety .
  • Jarvik , G. , Rozek , L. , Brophy , V. , Hatsukami , T. , Richter , R. , Schellenberg , G. and Furlong , C. 2000 . Paraoxonase (PON1) phenotype is a better predictor of vascular disease than is PON1192 or PON155 genotype . Arterioscler. Thomb. Vasc. Biol. , 20 : 2441 – 2447 .
  • Jonsson , F. and Johanson , G. 2001 . A Bayesian analysis of the influence of GSTT1 polymorphism on the cancer risk estimate for dichloromethane . Toxicol. Appl. Pharmacol. , 174 : 99 – 112 .
  • Kato , S. , Bowmann , E. D. , Harrington , A. M. , Blomeke , B. and Shields , P. G. 1995 . Human lung carcinogen-DNA adduct levels mediated by genetic polymorphisms in vivo . JNCI , 87 : 902 – 907 .
  • Kawamoto , T. , Koga , M. , Murata , K. , Matsuda , S. and Kodama , Y. 1995 . Effects of ALDH2, CYP1A1, and CYP2E1 genetic polymorphisms and smoking and drinking habits on toluene metabolism in humans . Toxicol. Appl. Pharmacol. , 133 : 295 – 304 .
  • Kedderis , G. L. 1997 . Extrapolation of in vitro enzyme induction data to humans in vivo . Chem. Biol. Interact. , 107 : 109 – 121 .
  • Kim , J. S. , Kim , Y. J. , Kim , T. Y. , Song , J. Y. , Cho , Y. H. , Park , Y. C. and Chung , H. W. 2005 . Association of ALDH2 polymorphism with sensitivity to acetaldehyde-induced micronuclei and facial flushing after alcohol intake . Toxicology , 210 : 169 – 174 .
  • Kim , B. S. and Smialowicz , R. J. 1997 . The role of metabolism in 2-methoxyethanol-induced suppression of in vitro polyclonal antibody responses by rat and mouse lymphocytes . Toxicology , 123 : 227 – 239 .
  • Kim , R. , O'Shea , D. and Wilkinson , G. 1995 . Interindividual variability of chlorzoxazone 6-hydroxylation in men and women and its relationship to cyp2E1 genetic polymorphisms . Clin. Pharmacol. Ther. , 57 : 645 – 666 .
  • Kitagawa , K. , Kawamoto , T. , Kunugita , N. , Tsukiyama , T. , Okamoto , K. , Yoshida , A. , Nakayama , K. and Nakayama , K. 2000 . Aldehyde dehydrogenase (ALDH2) 2 associates with oxidation of methoxyacetaldehyde; In vitro analysis with liver subcellular fraction derived from human and aldh2 gene targeting mouse . FEBS Lett. , 476 : 306 – 311 .
  • Klyosov , A. A. , Rashkovetsky , L. G. , Tahir , M. K. and Keung , W. M. 1996 . Possible role of liver cytosolic and mitochondrial aldehyde dehydrogenases in acetaldehyde metabolism . Biochemistry , 35 : 4445 – 4456 .
  • La Du , B. , Billecke , S. , Hsu , C. , Haley , R. and Broomfield , C. 2001 . Serum paraoxonase (PON1) isozymes: the quantitative analysis of isozymes affecting individual sensitivity to environmental chemicals . Drug Metab. Dispos. , 29 : 566 – 569 .
  • Landi , S. 2000 . Mammalian class theta GST and differential susceptibility to carcinogens: A review . Mutat. Res. , 463 : 247 – 283 .
  • Landi , S. , Norppa , H. , Frenzilli , G. , Cipollini , G. , Ponzanelli , I. , Barale , R. and Hirvonen , A. 1998 . Individual sensitivity to cytogenetic effects of 1,2:3,4-diepoxybutane in cultured human lymphocytes: Influence of glutathione S-transferase M1, P1 and T1 genotypes . Pharmacogenetics , 8 : 461 – 471 .
  • Larson , R. A. , Wang , Y. X. , Banerjee , M. , Wiemels , H. , Hartford , C. , LeBeau , M. M. and Smith , M. T. 1999 . Prevalence of the inactivation C-609→T polymorphism in the NAD(P)H;quinone oxidoreductase (NQO1) gene in patients with primary and therapy-related meyloid leukemia . Blood , 94 : 803 – 807 .
  • Leathart , J. , London , S. J. , Steward , A. , Adams , J. D. , Idle , J. R. and Daly , A. K. 1998 . CYP2D6 phenotype-genotype relationships in African-Americans and Caucasians in Los Angeles . Pharmacogenetics , 8 : 529 – 541 .
  • Li , W. , Costa , L. , Richter , R. , Hagen , T. , Shih , D. , Tward , A. , Lusis , A. and Furlong , C. 2000 . Catalytic efficiency determines the in-vivo efficacy of PON1 for detoxifying organophosphorus compounds . Pharmacogenetics , 10 : 767 – 779 .
  • Lieber , C. 1997 . Cytochrome P-4502E1: Its physiological and pathological role . Physiol. Rev. , 77 : 517 – 544 .
  • Lipscomb , J. C. 2003 . How differences in enzyme expression can translate into pharmacokinetic variance and susceptibility to toxicity . J. Child. Health , 1 : 189 – 202 .
  • Lipscomb , J. C. and Kedderis , G. L. 2002 . Incorporating human interindividual biotransformation variance in health risk assessment . Sci. Total Environ. , 288 : 13 – 21 .
  • Lipscomb , J. , Garrett , C. and Snawder , J. 1997 . Cytochrome P450-dependent metabolism of trichloroethylene: interindividual differences in humans . Toxicol. Appl. Pharmacol. , 142 : 311 – 318 .
  • Lipscomb , JC. , Teuschler , LK. , Swartout , J. , Popken , D. , Cox , T. and Kedderis , G. L. 2003 . The impact of cytochrome P450 2E1-dependent metabolic variance on risk-relevant pharmacokinetic outcome in humans . Risk Anal. , 23 : 1221 – 1238 .
  • Lunn , R. M. , Helzlsouer , K. J. , Parshad , R. , Umbach , D. M. , Harris , E. L. , Sanford , K. K. and Bell , D. A. 2000 . XPD polymorphisms: Effects on DNA repair proficiency . Carcinogenesis , 21 : 551 – 555 .
  • Ma , H. , An , J. , Hsie , A. W. and Au , W. W. 1993 . Mutagenicity and cytotoxicity of 2-methoxyethanol and its metabolites in Chinese hamster cells (the CHO and AS52/GPT assays) . Mutat. Res. , 298 : 219 – 225 .
  • Mahgoub , A. , Idle , J. R. , Dring , L. G. , Lancaster , R. and Smith , R. L. 1977 . Polymorphic hydroxylation of debrisoquine in man . Lancet , 2 : 584 – 586 .
  • McCarver , D. , Byun , R. , Hines , R. , Hichme , M. and Wegenek , W. 1998 . A genetic polymorhism in the regulatory sequences of human Cyp2E1: Association with increased chlorzoxazone hydroxylation in the presence of obesity and ethanol intake . Toxicol. Appl. Pharmacol. , 152 : 276 – 281 .
  • McLellan , R. , Oscarson , M. , Alexandrie , A. , Seidegard , J. , Evans , D. , Rannug , A. and Ingelman-Sundberg , M. 1997 . Characterization of a human glutathione S-transferase μ cluster containing a duplicated GSTM1 gene that causes ultrarapid enzyme activity . Mol. Pharmacol. , 52 : 958 – 965 .
  • Miller , M. S. , McCarver , D. G. , Bell , D. A. , Eaton , D. L. and Goldstein , J. A. 1997 . Genetic polymorphisms in human drug metabolic enzymes . Fundam. Appl. Toxicol. , 40 : 1 – 14 .
  • Miller , M. C. , Mohrenweiser , H. W. and Bell , D. A. 2001 . Genetic variability in susceptibility and response to toxicants . Toxicol. Lett. , 120 : 269 – 280 .
  • Mizoi , Y. , Yamamoto , K. , Ueno , Y. , Fukunaga , T. and Harada , S. 1994 . Involvement of genetic polymorphism of alcohol and aldehyde dehydrogenases in individual variation of alcohol metabolism . Alcohol Alcoholism , 29 : 707 – 710 .
  • Moran , J. L. , Siegel , D. and Ross , D. 1999 . A potential mechanism underlying the increased susceptibility of individuals with a polymorphism in NADPH:quinone oxidoreductase 1 (NQO1) to benzene toxicity . Proc. Natl. Acad. Sci. USA , 96 : 8150 – 8155 .
  • Nakajima , T. and Aoyama , T. 2000 . Polymorphism of drug-metabolizing enzymes in relation to individual susceptibility to industrial chemicals . Ind. Health , 38 : 143 – 152 .
  • National Research Council . 2000 . Scientific frontiers in developmental toxicology and risk assessment , Washington, DC : National Academy Press .
  • Nebert , D. W. 1991 . Polymorphism of human CYP2D genes involved in drug metabolism possible relationship to individual cancer risk . Cancer Cell , 3 : 93 – 96 .
  • Nebert , D. W. and Roe , A. L. 2001 . Ethnic and genetic differences in metabolism genes and risk of toxicity and cancer . Sci. Total Environ. , 274 : 93 – 102 .
  • Nedelcheva , V. , Gut , I. , Soucek , P. , Tichavska , B. , Tynkova , L. , Mraz , J. , Guengerich , F. and Ingelman-Sundberg , M. 1999 . Metabolism of benzene in human liver microsomes: Individual variations in relation to CYP2E1 expression . Arch. Toxicol. , 73 : 33 – 40 .
  • Norppa , H. , Hirvonen , A. , Jarventaus , H. , UuskOula , M. , Tasa , G. , OjajOarvi , A. and Sorsa , M. 1995 . Role of GSTT1 and GSTM1 genotypes in determining individual sensitivity to sister chromatid exchange induction by diepoxybutane in cultured human lymphocytes . Carcinogenesis , 16 : 1261 – 1264 .
  • Okumura , K. , Kita , T. , Chikazawa , S. , Komada , F. , Iwakaw , S. and Tanigawara , Y. 1997 . Genotyping of N-acetylation polymorphism and correlation with procainamide metabolism . Clin. Pharmacol. Ther. , 61 : 509 – 517 .
  • Ollikainen , T. , Hirvonen , A. and Norppa , H. 1998 . Influence of GSTT1 genotype on sister chromatid exchange induction by styrene-7, 8-oxide in cultured human lymphocytes . Environ. Mol. Mutagen. , 31 : 311 – 315 .
  • Patten , C. , Smith , T. , Murphy , S. , Wang , M. , Lee , J. , Tynes , R. , Koch , P. and Yang , C. 1996 . Kinetic analysis of the activation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone by heterologously expressed human P450 enzymes and the effect of P450-specific chemical inhibitors on this activation in human liver microsomes . Arch. Biochem. Biophys. , 333 : 127 – 138 .
  • Raimundo , S. , Toscano , C. , Klein , K. , Griese , E. U. , Eichelbaum , M. , Schwab , M. and Zanger , UM. 2004 . A novel intronic mutation, 2988G>A, with high predictivity for impaired function of cytochrome P450 2D6 in white subjects . Clin. Pharmacol. Ther. , 76 : 128 – 138 .
  • Reitz , R. H. , Gargas , M. L. , Mendrala , A. L. and Schumann , A. M. 1996 . In vivo and in vitro studies of perchloroethylene metabolism for physiologically based pharmacokinetic modeling in rats, mice, and humans . Toxicol. Appl. Pharmacol. , 136 : 289 – 306 .
  • Reitz , R. H. , Mendrala , A. L. and Guengerich , F. P. 1989 . In vitro metabolism of methylene chloride in human and animal tissues: Use in physiologically based pharmacokinetic models . Toxicol. Appl. Pharmacol. , 97 : 230 – 246 .
  • Renwick , A. G. 1998 . Toxicokinetics in infants and children in relation to the ADI and TDI . Food Addit. Contam. , 15 : 17 – 35 .
  • Renwick , A. G. and Lazarus , N. R. 1998 . Human variability and noncancer risk assessment—An analysis of the default uncertainty factor . Regul. Toxicol. Pharmacol. , 27 : 3 – 20 .
  • Roemer , H. C. , Weistenhofer , W. , Lohlein , D. , Geller , F. , Blomeke , B. and Golka , K. 2008 . N-Acetyltransferase 1 in colon and rectal cancer cases from an industrialized area . J. Toxicol. Environ. Health A , 71 : 902 – 905 .
  • Rojas , M. , Alexandrov , K. , Cascorbi , I. , Brockmoller , J. , Likhachev , A. , Pozharisski , K. , Bouvier , G. , Auburtin , G. , Mayer , L. , Kopp-Schneider , A. , Roots , I. and Bartsch , H. 1998 . High benzo[a]pyrene diol-epoxide DNA adduct levels in lung and blood cells from individuals with combined CYP1A1 MspI/MspI-GSTM1∗0/∗0 genotypes . Pharmacogenetics , 8 : 109 – 118 .
  • Rothman , N. , Smith , M. T. , Hayes , R. D. , Hoener , B. , Campleman , S. , Li , G. L. , Dosemeci , M. , Linet , M. , Zhang , L. , Xi , L. , Wacholder , S. , Lu , W. , Meyer , K. B. , Titenko-Holland , N. , Stewart , J. T. , Yin , S. and Ross , D. 1997 . Benzene poisoning, a risk factor for hematological malignancy, is associated with the NQO1 609C-T mutation and rapid fractional excretion of chlorzoxazone . Cancer Res. , 57 : 2839 – 2842 .
  • Sachse , C. , Brockmoller , J. , Bauer , S. and Roots , I. 1997 . Cytochrome P450 2D6 variants in a Caucasian population: Allele frequencies and phenotypic consequences . Am. J. Hum. Genet. , 60 : 284 – 295 .
  • Sams , C. , Mason , H. J. and Rawbone , R. 2000 . Evidence for the activation of organophosphate pesticides by cytochromes P450 3A4 and 2D6 in human liver microsomes . Toxicol. Lett. , 116 : 217 – 221 .
  • Seidegard , J. and Ekstrom , G. 1997 . The role of human glutathione transferases and epoxide hydrolases in the metabolism of xenobiotics . Environ. Health Perspect. , 105 : 791 – 799 .
  • Shih , D. , Gu , L. and Xia , Y. 1998 . Mice lacking serum paraoxonase are susceptible to organophosphate toxicity and atherosclerosis . Nature , 394 : 284 – 287 .
  • Shimada , T. , Tsumura , F. and Yamazaki , H. 1999 . Prediction of human liver microsomal oxidations of 7-ethoxycoumarin and chlorzoxazone with kinetic parameters of recombinant cytochrome P-450 enzymes . Drug Metab. Dispos. , 27 : 1274 – 1280 .
  • Smolen , A. , Eckerson , H. , Gan , K. , Hailat , N. and LaDu , B. 1991 . Characteristics of the genetically determined polymorphic forms of human serum paraoxonase/arylesterase . Drug Metab. Dispos. , 19 : 107 – 112 .
  • Sprenger , R. , Schlagenhaufer , R. , Kerb , R. , Bruhn , C. , Brockmoller , J. , Roots , I. and Brinkmann , U. 2000 . Characterization of the glutathione S-transferase GSTT1 deletion: Discrimination of all genotypes by polymerase chain reaction indicates a trimodular genotype-phenotype correlation . Pharmacogenetics , 10 : 557 – 565 .
  • Srivastava , S. K. , Singhal , S. S. , Hu , X. , Awasthi , Y. C. , Zimniak , P. and Singh , S. V. 1999 . Differential catalytic efficiency of allelic variants of human glutathione S-transferase Pi in catalyzing the glutathione conjugation of thiotepa1 . Arch. Biochem. Biophys. , 366 : 89 – 94 .
  • Stucker , I. , Hirvonin , A. , deWaziers , I. , Cabelguenne , A. , Mitrunen , K. , Cenee , S. , Koum-Besson , E. , Hemon , D. , Beaune , P. and Loriot , MA. 2002 . Genetic polymorphisms of glutathione S-transferases as modulators of lung cancer susceptibility . Carcinogenesis , 23 : 1475 – 1481 .
  • Taningher , M. , Malacarne , D. , Izzotti , A. , Ugolini , D. and Parodi , S. 1999 . Drug metabolism polymorphisms as modulators of cancer susceptibility . Mutat. Res. , 436 : 227 – 261 .
  • Tateishi , T. , Chida , M. , Ariyoshi , N. , Mizorogi , Y. , Kamataki , T. and Kobayashi , S. 1999 . Analysis of the CYP2D6 gene in relation to dextromethorphan O-demethylation capacity in a Japanese population . Clin. Pharmacol. Ther. , 65 : 570 – 575 .
  • Teeguarden , J. G. , Bogdanffy , M. S. , Covington , T. R. , Tan , C. and Jarabek , A. M. 2008 . A PBPK model for evaluating the impact of aldehyde dehydrogenase polymorphisms on comparative rat and human nasal tissue acetaldehyde dosimetry . Inhal. Toxicol. , 20 : 375 – 390 .
  • Thier , R. , Wiebel , F. , Hinkel , A. , Burger , A. , Bruning , T. , Morgenroth , K. , Senge , T. , Wilhelm , M. and Schulz , T. 1998 . Species differences in the glutathione transferase GSTT1-1 activity towards the model substrates methyl chloride and dichloromethane in liver and kidney . Arch. Toxicol. , 72 : 622 – 629 .
  • Their , R. , Balkenhol , H. , Lewalter , J. , Selinski , S. , Dommermuth , A. and Bolt , H. M. 2001 . Influence of polymorphisms of the human glutathione transferases and cytochrome P450 2E1 enzyme on the metabolism and toxicity of ethylene oxide and acrylonitrile . Mutat. Res. , 482 : 41 – 46 .
  • Thier , R. , Bruning , T. , Roos , P. H. , Rihs , H. P. , Golka , K. , Ko , Y. and Bolt , H. M. 2003 . Markers of genetic susceptibility in human environmental hygiene and toxicology: The role of selected CYP, NAT and GST genes . Int. J. Hyg. Environ. Health , 206 : 149 – 171 .
  • Toscano , C. , Klein , K. , Blievernicht , J. , Schaeffeler , E. , Saussele , T. , Raimundo , S. , Eichelbaum , M. , Schwab , M. and Zanger , UM. 2006 . Impaired expression of CYP2D6 in intermediate metabolizers carrying the ∗41 allele caused by the intronic SNP 2988G>A: Evidence for modulation of splicing events . Pharmacogenet. Genom. , 16 : 755 – 766 .
  • Traver , R. D. , Hoikoshi , T. , Danenberg , K. D. , Stadlbauer , T. H. W. , Danenberg , P. V. , Ross , D. and Gibson , N. W. 1992 . NAD(P)H:quinone oxidoreductase gene expression in human colon carcinoma cells: characterization of a mutation which modulates DT-diaphorase activity and mitomycin sensitivity . Cancer Res. , 52 : 797 – 802 .
  • Uchimoto , T. , Itoga , S. , Nezu , M. , Sunaga , M. , Tomonaga , T. and Nomura , F. 2007 . Role of the genetic polymorphisms in the 5’ flanking region for transcriptional regulation of the human CYP2E1 gene . Alcohol. Clin. Exp. Res. , 31 : 36S – 42S .
  • U.S. Environmental Protection Agency. 2004. IRIS profile for boron and compounds http://www.epa.gov/ncea/iris/subst/0410.htm (Accessed: 16 December 2008 ).
  • Vasiliou , V. and Pappa , A. 2000 . Polymorphisms of human aldehyde dehydrogenases . Pharmacology , 61 : 192 – 198 .
  • Venkatakrishnan , K. , Von Molpke , L. L. , Court , M. H. , Harmatz , J. S. , Crespi , C. L. and Greenblatt , D. J. 2000 . Comparison between cytochrome P-450 (CYP) content and relative activity approaches to scaling from cDNA-expressed CYPs to human liver microsomes: Ratios of accessory proteins as sources of discrepancies between the approaches . Drug Metab. Dispos. , 28 : 1493 – 1504 .
  • Vitarius , J. and Sultatos , L. 1994 . Kinetic mechanism of the detoxification of the organophosphate paraoxon by human serum A-esterase . Drug Metab. Dispos. , 22 : 472 – 478 .
  • Vodicka , P. , Soucek , P. , Tates , A. , Dusinska , M. , Sarmanova , J. , Zamecnikova , M. , Vodickova , L. , Koskinen , M. , de Zwart , F. , Natarajan , A. and Hemminki , K. 2001 . Association between genetic polymorphisms and biomarkers in styrene-exposed workers . Mutat. Res. , 482 : 89 – 103 .
  • Watanabe , J. , Hayashi , S. and Nakachi , K. 1994 . Different regulation and expression of the human CYP2E1 gene due to Rsa I polymorphism in the 5’-flanking region . J. Biochem. , 116 : 32 – 326 .
  • Watson , M. A. , Stewart , R. K. , Graeme , B. J. S. , Massey , T. E. and Bell , D. A. 1998 . Human glutathione S-transferase P1 polymorphisms: Relationship to lung tissue enzyme activity and population frequency distribution . Carcinogenesis , 19 : 275 – 280 .
  • Whalen , R. and Boyer , T. 1998 . Human glutathione S-transferase . Semin. Liver Dis. , 18 : 345 – 358 .
  • Weistenhofer , W. , Blaskzkewicz , M. , Bolt , H. M. and Golka , K. 2008 . N-Acetyltransferase-2 and medical history in bladder cancer cases with a suspected occupational disease (BK 1301) in Germany . J. Toxicol. Environ. Health A , 71 : 906 – 910 .
  • Windmill , K. F. , McKinnon , R. A. , Zhu , X. , Gaedigk , A. , Grant , D. M. and McManus , M. E. 1997 . The role of xenobiotic metabolizing enzymes in arylamine toxicity and carcinogenesis: Functional and localization studies . Mutat. Res. , 376 : 153 – 160 .
  • Wormhoudt , L. , Commandeur , J. and Vermeulen , N. 1999 . Genetic polymorphisms of human N-acetyltransferase, cytochrome P450, glutathione-S-transferase, and epoxide hydrolase enzymes: relevance to xenobiotic metabolism and toxicity . Crit. Rev. Toxicol. , 29 : 59 – 124 .
  • Yamazaki , H. , Guo , Z. and Guengerich , F. P. 1995 . Selectivity of cytochrome P4502E1 in chlorzoxazone 6-hydroxylation . Drug Metab. Dispos. , 23 : 438 – 440 .
  • Yokoyama , A. , Muramatsu , T. , Ohmori , T. , Yokoyama , T. , Okuyama , K. , Takahashi , H. , Hasegawa , Y. , Higuchi , S. , Maruyama , K. , Shirakura , K. and Ishii , H. 1998 . Alcohol-related cancers and aldehyde dehydrogenase-2 in Japanese alcoholics . Carcinogenesis , 19 : 1383 – 1387 .
  • Yokoyama , A. , Muramatsu , T. , Omori , T. , Yokoyama , T. , Matsushita , S. , Higuchi , S. , Maruyama , K. and Ishii , H. 2001 . Alcohol and aldehyde dehydrogenase gene polymorphisms and oropharyngolaryngeal, esophageal and stomach cancers in Japanese alcoholics . Carcinogenesis , 22 : 433 – 439 .
  • Zanger , U. M. , Raimundo , S. and Eichelbaum , M. 2004 . Cytochrome P450 2D6: Overview and update on pharmacology, genetics, biochemistry . Naunyn Schmiedebergs Arch. Pharmacol. , 369 : 23 – 37 .
  • Zimmermann , A. , Blaszkewicz , M. , Roth , G. , Seidel , T. , Dietrich , H. , Schutschkow , O. , Bolt , H. M. and Golka , K. 2008 . UDP-glucuronosyltransferase 2B7 C802T (His268Tyr) polymorphism in bladder cancer cases . J. Toxicol. Environ. Health A , 71 : 911 – 914 .

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