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Original Articles

Genetic Polymorphism in CYP2E1: Population Distribution of CYP2E1 Activity

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Pages 362-388 | Published online: 06 Oct 2009

REFERENCES

  • Agundez , J. , Rodriguez , I. , Olivera , M. , Ladero , J. , Garcia , M. , Ribera , J. and Benitez , J. 1997 . CYP2D6, NAT2 and CYP2E1 genetic polymorphisms in nonagenarians . Age Ageing , 26 : 147 – 151 .
  • Albano , E. , Tomasi , A. , Goria-Gatti , L. , Persson , O. , Tereius , Y. , Goria-Gatti , L. , Ingelman-Sundberg , M. and Dianzani , M. 1991 . Role of ethanol-inducible cytochrome P450 (P450IIEI) in catalyzing the free radical activation of aliphatic alcohols . Biochem. Pharmacol. , 41 : 1895 – 1902 .
  • Antonarakis , S. E. 1998 . Recommendations for a nomenclature system for human gene mutations . Nomenclature Working Group , 11 : 1 – 3 .
  • Anwar , W. , Abdel-Rahman , S. , El-Zein , R. , Mostafa , H. and Au , W. 1996 . Genetic polymorphism of GSTM1, CYP2E1 and CYP2D6 in Egyptian bladder cancer patients . Carcinogenesis , 17 : 1923 – 1929 .
  • Barcelo , S. , Gardiner , J. , Gescher , A. and Chipman , J. 1996 . CYP2E1-mediated mechanism of anti-genotoxicity of the broccoli constituent sulforphane . Carcinogenesis (Lond.) , 17 : 277 – 282 .
  • Block , G. , Patterson , B. and Subar , A. 1992 . Fruit, vegetables and cancer prevention: A review of the epidemiological evidence . Nutr. Cancer , 18 : 1 – 29 .
  • Boccia , S. , DeLauretis , A. , Gianfagna , F. , van Duijn , C. M. and Ricciardi , G. 2007 . CYP2E1 PstI/RsaI polymorphism and interaction with tobacco, alcohol and GSTs in gastric cancer susceptibility: A meta-analysis of the literature . Carcinogenesis , 28 : 101 – 106 .
  • Bolt , H. M. , Roos , P. H. and Thier , R. 2003 . The cytochrome P-450 isoenzyme CYP2E1 in the biological processing of industrial chemicals: Consequences for occupational and environmental medicine . Int. Arch. Occup. Environ. Health , 76 : 174 – 185 .
  • Borowsky , S. and Lieber , C. 1978 . Interaction of methadone and ethanol metabolism . J. Pharmacol. Exp. Ther. , 207 : 123 – 129 .
  • Brady , J. , Ishizaki , H. , Fukuto , J. , Lin , M. , Fadel , A. , Gupac , J. and Yang , C. 1991 . Inhibition of cytochrome P-450 2E1 by diallyl sulfide and its metabolites . Chem. Res.Toxicol. , 4 : 642 – 647 .
  • Brockmoller , J. , Cascorbi , I. , Kerb , R. and Roots , I. 1996 . Combined analysis of inherited polymorphisms in arylamine N-acetyltransferase 2, glutathione S-transferases M1 and T1, microsomal epoxide hydrolase, and cytochrome P450 enzymes as modulators of bladder cancer risk . Cancer Res. , 56 : 3915 – 3925 .
  • Carriere , V. , Goasduff , T. , Ratanasavanh , D. , Morel , F. , Gautier , J. C. , Guillouzo , A. , Beaune , P. and Berthou , F. 1993 . Both cytochrome P450 2E1 and 1A1 are involved in the metabolism of chlorzaxazone . Chem. Res. Toxicol. , 6 : 852 – 857 .
  • Carriere , V. , Berthou , F. , Baird , S. , Belloc , C. , Beaune , P. and de Waziers , I. 1996 . Human cytochrome P450 2E1: From genotype to phenotype . Pharmacogenetics , 6 : 203 – 211 .
  • Carroccio , A. , Wu , D. and Cederbaum , AI. 1994 . Ethanol increases content and activity of human cytochrome P4502E1 in a transduced HepG2 cell line . Biochem. Biophys. Res. Commun. , 203 : 727 – 733 .
  • Cartmell , M. T. , Schulz , H. U. , O'Reilly , D. A. , Yang , B. M. , Kielstein , V. , Dunlop , S. P. , Halangk , W. , Demaine , A. G. and Kingsnorth , A. N. 2005 . Cytochrome P450 2E1 high activity polymorphism in alcohol abuse and end-organ disease . World J. Gastroenterol. , 11 : 6445 – 6449 .
  • Chao , Y. , Young , T. , Chang , W. , Tang , H. and Hsu , C. 1995 . An investigation of whether polymorphisms of cytochrome P4502E1 are genetic markers of susceptibility to alcoholic end-stage organ damage in a Chinese population . Hepatology , 22 : 1409 – 1414 .
  • Cho , E. Y. , Yun , C. H. , Chae , H. Z. , Chae , H. J. and Ahn , T. 2008a . Anionic phospholipids-induced regulation of reactive oxygen species production by human cytochrome P450 2E1 . FEBS Lett. , 582 : 1771 – 1776 .
  • Cho , E. Y. , Yun , C. H. , Chae , H. Z. , Chae , H. J. and Ahn , T. 2008b . Lysophophatidylserine-induced functional switch of human cytochrome P450 1A2 and 2E1 from monooxygenase to phospholipase D . Biochem. Biophys. Res. Commun. , 376 : 584 – 589 .
  • Cho , U. S. , Park , E. Y. , Dong , M. S. , Park , B. S. , Kim , K. and Kim , K. H. 2003 . Tight-binding inhibition by alpha-naphthaoflavone of cytochrome P450 1A2 . Biochim. Biophys. Acta , 1648 : 195 – 202 .
  • Chen , K. , Day , N. , Duffy , S. , Lam , T. , Fok , M. and Wong , J. 1992 . Pickled vegetables in the etiology of esophageal cancer in Hong Kong Chinese . Lancet , 339 : 1314 – 1318 .
  • Degawa , M. , Stern , S. , Martin , M. , Guengerich , F. , Fu , P. , Ilett , K. , Kaderlik , R. and Kadlubar , F. 1994 . Metabolic activation and carcinogen DNA adduct detection in human larynx . Cancer Res. , 54 : 4915 – 4919 .
  • den Dunnen , J. T. and Antonarakis , S. E. 2001 . Nomenclature for the description of human sequence variations . Hum. Genet. , 109 : 121 – 124 .
  • Diehl , A. M. , Bisgaard , H. C. , Kren , B. T. and Steer , C. J. 1991 . Ethanol interferes with regeneration-associated changes in biotransforming enzymes: A potential mechanism underlying ethanol's carcinogenicity? . Hepatology , 13 : 722 – 727 .
  • Dong , Z. , Hong , J. , Ma , Q. , Li , DC. , Bullock , J. , Gonzalez , F. J. , Park , S. S. , Gelboin , H. V. and Yang , C. S. 1988 . Mechanism of induction of cytochrome P-450ac (P-450j) in chemically induced and spontaneously diabetic rats . Arch. Biochem. Biophys. , 263 : 29 – 35 .
  • d'Errico , A. , Malats , N. , Vineis , P. and Boffetta , P. 1999 . “ Review of studies of selected metabolic polymorphisms and cancer ” . In Metabolic polymorphisms and susceptibility to cancer , Edited by: Vineis , P. , Malats , N. , Lang , M. , d'Errico , A. , Caporaso , N. , Cuzick , J. and Boffetta , P. 323 – 345 . Lyon : International Agency for Research on Cancer (IARC) . Scientific Publication No. 148
  • Eap , C. B. , Schnyder , C. , Besson , J. , Savary , L. and Buclin , T. 1998 . Inhibition of CYP2E1 by chlormethiazole as measured by chlorzoxazone pharmacokinetics in patients with alcoholism and in healthy volunteers . Clin. Pharmacol. Ther. , 64 : 52 – 57 .
  • Eliasson , E. , Johansson , I. and Ingelman-Sundberg , M. 1988 . Ligand dependent maintenance of ethanol inducible cytochrome P-450 in primary rat hepatocyte cell cultures . Biochem. Biophys. Res. Commun. , 150 : 436 – 443 .
  • Ernstgard , LW. , Warholm , M. and Johanson , G. 2004 . Robustness of chlorzoxazone as an in vivo measure of cytochrome P450 2E1 activity . Br. J. Clin. Pharmacol. , 58 : 190 – 200 .
  • Fairbrother , K. , Grove , J. , Waziers , I. , Steimel , D. , Day , C. , Crespi , C. and Daly , A. 1998 . Detection and characterization of novel polymorphisms in the CYP2E1 gene . Pharmacogenetics , 8 : 543 – 552 .
  • Farker , K. , Lehmann , M. , Kastner , R. , Hoffman , A. , Janitzky , V. , Schubert , J. , Matz , U. and Hofmann , W. 1998 . CYP2E1 genotyping in renal cell/urothelial cancer patients in comparison with control populations . Int. J. Clin. Pharmacol. Ther. , 36 : 463 – 468 .
  • Fritsche , E. , Pittman , G. S. and Bell , D. A. 2000 . Localization, sequence analysis and ethnic distribution of a 96 bp insertion in the promoter of the human CYP2E1 gene . Mutat. Res. Genom. , 432 : 1 – 5 .
  • Gannett , P. , Iversen , P. and Lawson , T. 1990 . The mechanism of inhibition of cytochrome P-450IIE1 by dihydrocapsaicin . Bioorg. Chem. , 18 : 185 – 198 .
  • George , J. , Byth , K. and Farrell , G. 1995 . Age but not gender selectively affects expression of individual cytochrome P450 proteins in human liver . Biochem. Pharmacol. , 50 : 727 – 730 .
  • Ginsberg , G. , Smolenski , S. , Hattis , D. and Sonawane , B. 2002 . Population distribution of aldehyde dehydrogenase-2 genetic polymorphism: Implications for risk assessment . Regul. Toxicol. Pharmacol. , 36 : 297 – 309 .
  • Girre , C. , Lucas , D. , Hispard , E. , Menez , C. , Dally , S. and Menez , J. 1994 . Assessment of cytochrome P450 2E1 induction in alcoholic patients by chlorzoxazone pharmacokinetics . Biochem. Pharmacol. , 47 : 1503 – 1508 .
  • Guengerich , F. and Turvy , C. 1991 . Comparison of levels of several human microsomal cytochrome P-450 enzymes and epoxide hydrolase in normal and disease states using immunochemical analysis of surgical liver samples . J. Pharmacol. Exp. Ther. , 256 : 1189 – 1194 .
  • Guengerich , F. , Kim , D. and Iwasaki , M. 1991 . Role of human cytochrome P-450IIE1 in the oxidation of many low molecular weight cancer suspects . Chem. Res. Toxicol. , 4 : 168 – 179 .
  • Gut , I. , Nedelcheva , V. , Soucek , P. , Stopka , P. and Tichavska , B. 1996 . Cytochromes P450 in benzene metabolism and involvement of their metabolites and reactive oxygen species in toxicity . Environ. Health Perspect. , 104 : 1211 – 1218 .
  • Hanoika , N. , Tanaka-Kagawa , T. , Miyata , Y. , Makino , Y. , Ohno , A. , Yoda , R. , Jinno , H. and Ando , M. 2003 . Functional characterization of three human cytochrome p450 2E1 variants with amino acid substitutions . Xenobiotica , 33 : 575 – 586 .
  • Hasumura , Y. , Teschke , R. and Lieber , C. S. 1975 . Acetaldehyde oxidation by hepatic mitochondria: decrease after chronic ethanol consumption . Science , 189 : 727 – 729 .
  • Hayashi , S. , Watanabe , J. and Kawajiri , K. 1991 . Genetic polymorphisms in the 5′-flanking region change transcriptional regulation of the human cytochrome P450IIE1 gene . J. Biochem. , 110 : 559 – 565 .
  • Hildesheim , A. , Anderson , L. , Chen , C. , Cheng , Y. , Brinton , L. , Daly , A. , Reed , C. , Chen , I. , Caporaso , N. , Hsu , M. , Chen , J. , Idle , J. , Hoover , R. , Yang , C. and Chhabra , S. 1997 . CYP2E1 genetic polymorphisms and risk of nasopharyngeal carcinoma in Taiwan . JNCI , 89 : 1207 – 1212 .
  • Hirvonen , A. , Husgafvel-Pursiainen , K. , Anttila , S. , Karjalainen , A. and Vainio , H. 1993 . The human CYP2E1 gene and lung cancer: DraI and RsaI restriction fragment length polymorphisms in a Finnish study population . Carcinogenesis , 14 : 85 – 88 .
  • Hong , J. , Pan , J. , Gonzalez , F. , Gelboin , H. and Yang , C. 1987 . The induction of a specific form of cytochrome P450 (P450j) by fasting . Biochem. Biophys. Res. Commun. , 142 : 1077 – 1083 .
  • Howard , L. A. , Micu , A. L. , Sellers , E. M. and Tyndal , R. F. 2001 . Low doses of ethanol and nicotine induce CYP2E1 and chlorzoxazone metabolism in rat liver . J. Pharmacol. Exp. Ther. , 299 : 542 – 550 .
  • Hu , Y. , Oscarson , M. , Johansson , I. , Yue , Q. , Dahl , M. , Tabone , M. , Arinco , S. , Albano , E. and Ingelman-Sundberg , M. 1997 . Genetic polymorphism of human CYP2E1: Characterization of two variant alleles . Mol. Pharmacol. , 51 : 370 – 376 .
  • Hu , Y. , Hakkola , J. , Oscarson , M. and Ingelman-Sundberg , M. 1999 . Structural and functional characterization of the 5’-flanking region of the rat and human cytochrome P450 2E1 genes: Identification of a polymorphic repeat in the human gene . Biochem. Biophys. Res. Commun. , 263 : 286 – 293 .
  • Huang , Y. S. , Chern , H. D. , Su , W. J. , Wu , J. C. , Chang , S. C. , Chiang , C. H. , Chang , F. Y. and Lee , S. D. 2003 . Cytochrome P450 2E1 genotype and the susceptibility to antituberculosis drug-induced hepatitis . Hepatology , 37 : 924 – 930 .
  • Hukkanen , J. , Hakkola , J. , Anttila , S. , Piipari , R. , Karjalainen , A. , Pelkonen , O. and Raunio , H. 1997 . Detection of mRNA encoding xenobiotic-metabolizing cytochrome P450 s in human bronchoalveolar macrophages and peripheral blood lymphocytes . Mol. Carcinogen. , 20 : 224 – 230 .
  • Hung , H. , Chuang , J. , Chien , Y. , Chern , H. , Chiang , C. , Hidesheim , A. and Chen , C. 1997 . Genetic polymorphisms of CYP2E1, GSTM1, and GSTT1: Environmental factors and risk of oral cancer . Cancer Epidemiol. Biomarkers Prev. , 6 : 901 – 905 .
  • Ingleman-Sundberg , M. and Hagbjörk , A. 1982 . On the significance of the cytochrome P-450-dependent hydroxyl radical mediated oxygenation mechanism . Xenobiotica , 12 : 673 – 686 .
  • Ingleman-Sundberg , M. and Johannson , I. 1984 . Mechanisms of hydroxyl radical formation and ethanol oxidation by ethanol-inducible and other forms of rabbit liver microsomal cytochromes P–450 . J. Biol. Chem. , 259 : 6447 – 6458 .
  • Ingleman-Sundberg , M. , Johannson , I. , Yin , H. , Terelius , Y. , Eliasson , E. , Clot , P. and Albano , E. 1993 . Ethanol-inducible cytochrome P4502E1: Genetic polymorphism, regulation, and possible role in the etiology of alcohol-induced liver disease . Alcohol , 10 : 447 – 452 .
  • Inoue , K. , Yamazaki , H. and Shimada , T. 2000 . Characterization of liver microsomal 7-ethoxycoumarin O-deethylation and chlorzoxazone 6-hydroxylation activities in Japanese and Caucasian subjects genotyped for CYP2E1 gene . Arch. Toxicol. , 74 : 372 – 378 .
  • Ishizaki , H. , Brady , J. , Ning , S. and Yang , C. 1990 . Effect of phenethyl isothiocyanate on microsomal N-nitroxodimethylamine metabolism and other monooxygenase activities . Xenobiotica , 20 : 255 – 264 .
  • Iwahashi , K. , Matsuo , Y. , Suwaki , H. , Nakamura , K. and Ichikawa , Y. 1995 . CYP2E1 and ALDH2 genotype and alcohol dependence in Japanese . Alcohol Clin. Exp. Res. , 19 : 564 – 566 .
  • Iwahashi , K. , Ameno , S. , Ameno , K. , Okada , N. , Kinoshita , H. , Sakae , Y. , Nakamura , K. , Watanabe , M. , Ijiri , I. and Harada , S. 1998 . Relationship between alcoholism and CYP2E1 C/D polymorphism . Neuropsychobiology , 38 : 218 – 221 .
  • Johansson , I. and Ingelman-Sundberg , M. 1988 . Benzene metabolism by ethanol-, acetone-, and benzene-inducible cytochrome P-450 (IIEI) in rat and rabbit liver microsomes . Cancer Res. , 48 : 5387 – 5390 .
  • Johns , D. O. , Daniell , W. E. , Shen , D. D. , Kalman , D. A. , Dills , R. L. and Morgan , M. S. 2006 . Ethanol-induced increase in the metabolic clearance of 1,1,1-trichloroethane in human volunteers . Toxicol. Sci. , 92 : 61 – 70 .
  • Joly , J. and Hetu , C. 1975 . Effects of chronic ethanol administration in the rat. Relative dependency on dietary lipids. I. Induction of hepatic drug-metabolism enzymes in vitro . Biochem. Pharmacol. , 24 : 1475 – 1480 .
  • Joly , J. and Hetu , C. 1977 . Effects of chronic ethanol administration in the rat. Relative dependency on dietary lipids. II. Paradoxical role of linoleate in the induction of hepatic drug metabolizing enzymes in vitro . Can. J. Physiol. Pharmacol. , 55 : 34 – 41 .
  • Kato , S. , Shields , P. , Caporaso , N. , Hoover , R. , Trump , B. , Sugimura , H. , Weston , A. and Harris , C. 1992 . Cytochrome P450IIE1 genetic polymorphisms, racial variation, and lung cancer risk . Cancer Res. , 52 : 6712 – 6715 .
  • Kato , S. , Shield , P. G. , Caporaso , N. E. , Sugimura , H. , Trivers , G. E. , Tucker , M. A. , Trump , B. F. , Weston , A. and Harris , C. C. 2003 . CYP2E1: Biochemistry, toxicology, regulation and function in ethanol-induced liver injury . Curr. Mol. Med. , 3 : 509 – 518 .
  • Kessova , I. and Cederbaum , A. I. 1994 . Analysis of cytochrome P450 2E1 genetic polymorphisms in relation to human lung cancer . Cancer Epididemiol. Biomarkers Prev. , 3 : 515 – 518 .
  • Kedderis , G. L. 1997 . Extrapolation of in vitro enzyme induction data to humans in vivo . Chem. Biol. Interact. , 107 : 109 – 121 .
  • Khani , S. , Zaphiropoulos , P. , Fujita , V. , Porter , T. , Koop , D. and Coon , M. 1987 . cDNA and derived amino acid sequence of ethanol-inducible rabbit liver cytochrome P-450 isozyme 3a (P-450ALC) . Proc. Natl. Acad. Sci. USA , 84 : 638 – 642 .
  • Khemawoot , P. , Nishino , K. , Ishizaki , J. , Yokogawa , K. and Miyamoto , K. 2007 . Circadian rhythm of cytochrome P4502E1 and its effect on disposition kinetics of chlorzoxazone in rats . Eur. J. Pharmacol. , 574 : 71 – 76 .
  • Kim , S. and Novak , R. 1990 . Induction of rat hepatic P-450IIEI (CYP 2E1) by pyridine: Evidence for a role of protein synthesis in the absence of transcriptional activation . Biochem. Biophys. Res. Commun. , 166 : 1072 – 1079 .
  • Kim , R. , O'Shea , D. and Wilkinson , G. 1995 . Interindividual variability of chlorzoxazone 6-hydroxylation in men and women and its relationship to cyp2E1 genetic polymorphisms . Clin. Pharmacol. Ther. , 57 : 645 – 666 .
  • Kim , R. , Yamazaki , H. , Chiba , K. , O'Shea , D. , Mimura , M. , Guengerich , P. , Ishizaki , T. , Shimada , T. and Wilkinson , G. 1996 . In vivo and in vitro characterization of CYP2E1 activity in Japanese and Caucasians . Pharmacol. Exp. Ther. , 279 : 4 – 11 .
  • Kim , J. , Lee , C. , Park , Y. , Kim , K. , Kim , I. , Sohn , Y. , Min , H. , Lee , J. and Namkoong , S. 2000 . Combined analysis of germline polymorphisms of p53, GSTM1, GSTT1, CYP1A1 and CYP2E1: Relation to the incidence rate of cervical carcinoma . Cancer , 88 : 2082 – 2091 .
  • Kiss , I. , Sandor , J. , Pajkos , G. , Bogner , B. , Hegedus , G. and Ember , I. 2000 . Colorectal cancer risk in relation of genetic polymorphism of cytochrome P450 1A1, 2E1, and GSTM1 enzymes . Anticancer Res. , 20 : 519 – 522 .
  • Kirvisto , K. , Linder , A. , Friedel , G. , Beaune , P. , Belloc , C. , Kroemer , H. and Fritz , P. 1995 . Immunohistochemical localization of cytochrome P4502E1 in human pulmonary carcinoma and normal bronchial tissue . Virchows Arch. Toxicol. , 426 : 243 – 247 .
  • Kolm , R. , Danielson , U. , Zhang , Y. , Talalay , P. and Mannervik , B. 1995 . Isothiocyannates as substrates for human glutathione transferase: structure–activity studies . Biochem. J. , 311 : 453 – 459 .
  • Koop , D. 1992 . Oxidative and reductive metabolism by cytochrome P450 2E1 . FASEB J. , 6 : 724 – 730 .
  • Koop , D. , Crump , B. , Nordblom , G. and Coon , M. 1985 . Immunochemical evidence for induction of the alcohol-oxidizing cytochrome P-450 of rabbit liver microsomes by diverse agents: Ethanol, imidazole, trichloroethylene, acetone, pyrazole and isoniazid . Proc. Natl. Acad. Sci. USA , 82 : 4065 – 4069 .
  • Krishna , D. and Klotz , U. 1994 . Extrahepatic metabolism of drugs in humans . Clin. Pharmacokinet. , 26 : 144 – 160 .
  • Kubota , S. , Lasker , J. and Lieber , C. 1988 . Molecular regulation of ethanol inducible cytochrome P-450-IIEI in hamsters . Biochem. Biophys. Res. Commun. , 150 : 304 – 310 .
  • Ladero , L. , Agundez , J. , Rodriguez-Lescure , A. , Diaz-Rubio , M. and Benitez , J. 1996 . RsaI polymorphism at the cytocrome P4502E1 locus and risk of hepatocellular carcinoma . Gut , 39 : 330 – 333 .
  • Lechevrel , M. , Casson , A. , Wolf , C. , Hardie , L. , Flinterman , M. , Montesano , R. and Wild , C. 1999 . Characterization of cytochrome P450 expression in human oesophageal mucosa . Carcinogenesis , 20 : 243 – 248 .
  • Leclercq , I. , Desago , J. and Horsman , Y. 1998 . Inhibition of chlorzoxazone metabolism, a clinical probe for CYP2E1, by a single ingestions of watercress . Clin. Pharmacol. Ther. , 64 : 144 – 149 .
  • Lee , S. , Buters , J. , Pineau , T. , Fernandez-Salguero , P. and Gonzalez , F. 1996 . Role of CYP2E1 in the hepatotoxicity of acetaminophen . J. Biol. Chem. , 271 : 12063 – 12067 .
  • Lee , A. M. , Yue , J. and Tyndale , R. F. 2006 . In vivo and in vitro characterization of chlorzoxazone metabolism and hepatic CYP2E1 levels in African Green monkeys: Induction by chronic nicotine treatment . Drug Metab. Dispos. , 34 : 1508 – 1515 .
  • Le Marchand , L. , Sivaraman, Pierce , L. , Seifried , A. , Lum , A. , Wilkens , L. and Lau , A. 1998 . Associations of CYP1A1, GSTM1, and CYP2E1 polymorphisms with lung cancer suggest cell type specificities to tobacco carcinogens . Cancer Res. , 58 : 4858 – 4863 .
  • Le Marchand , L. , Wilkinson , G. and Wilkens , L. 1999 . Genetic and dietary predictors of CYP2E1 activity: A phenotyping study in Hawaii Japanese using chlorzoxazone . Cancer Epidemiol. Biomarkers Prev. , 8 : 495 – 500 .
  • Levin , W. , Thomas , P. , Oldfield , N. and Ryan , D. 1986 . N-Demethylation of N-nitrosodimethylamine catalyzed by purified rat hepatic microsomal cytochrome P-450: Isozyme specificity and role of cytochrome b5 . Arch. Biochem. Biophys. , 248 : 158 – 165 .
  • Li , D. , Dandara , C. and Parker , M. I. 2005 . Association of cytochrome P450 2E1 genetic polymorphisms with squamous cell carcinoma of the esophagus . Clin. Chem. Lab. Med. , 43 : 370 – 375 .
  • Lieber , C. 1994 . Alcohol and the liver: 1994 update . Hepatology , 106 : 1085 – 1105 .
  • Lieber , C. 1997a . Ethanol metabolism, cirrhosis and alcoholism . Clin. Chim. Acta , 257 : 59 – 84 .
  • Lieber , C. 1997b . Cytochrome P-4502E1: Its physiological and pathological role . Physiol. Rev. , 77 : 517 – 544 .
  • Lin , D. , Tang , Y. , Peng , Q. , Lu , S. , Ambrosone , C. and Kadlubar , F. 1998 . Susceptibility to esophageal cancer and genetic polymorphisms in glutathione S-transferases T1, P1, and M1 and cytochrome P4502E1 . Cancer Epidemiol. Biomarkers Prev. , 7 : 1013 – 1018 .
  • Lipscomb , J. C. 2003 . How differences in enzyme expression can translate into pharmacokinetic variance and susceptibility to toxicity . J. Child. Health , 1 : 189 – 202 .
  • Lipscomb , J. and Kedderis , G. 2002 . Incorporating human interindividual biotransformation variance in health risk assessment . Sci. Total Environ. , 288 : 13 – 21 .
  • Lipscomb , J. C. and Poet , T. S. 2008 . In vitro measurements of metabolism for application in pharmacokinetic modeling . Pharmacol. Ther. , 118 : 82 – 103 .
  • Lipscomb , J. , Garrett , C. and Snawder , J. 1997 . Cytochrome P450-dependent metabolism of trichloroethylene: Interindividual differences in humans . Toxicol. Appl. Pharmacol. , 142 : 311 – 318 .
  • Lipscomb , J. C. , Teuschler , L. K. , Swartout , J. C. , Striley , C. A. F. and Snawder , J. E. 2003 . Variance in microsomal protein content and cytochrome P450 2E1 and 3A forms in adult human liver . Toxicol. Mech. Methods , 13 : 45 – 51 .
  • Lucas , D. , Berthou , F. , Dreano , Y. , Lozac'h , P. , Volcent , A. and Menez , J. 1993 . Comparison of levels of cytochromes P450, CYP1A2, CYP2E1 and their related monooxygenase activities in human surgical liver samples . Alcohol Clin. Exp. Res. , 17 : 900 – 905 .
  • Lucas , D. , Gill , K. , Menez , J. and Deitrich , R. 1995a . Differences in cytochrome P450 2E1 and 1A1 genotyping between American Indians and Caucasians . Alcohol Clin. Exp. Res. , 19 : 74A
  • Lucas , D. , Menez , C. , Girre , C. , Berthou , F. , Bodenez , P. , Joannet , I. , Hispard , E. , Bardou , L. and Menez , J. 1995b . Cytochrome P450 2E1 genotype and chlorzoxazone metabolism in healthy and alcoholic Caucasian subjects . Pharmacogenetics , 5 : 298 – 304 .
  • Lucas , D. , Menez , C. , Girre , C. , Bodenez , P. , Hispard , E. and Menez , J. 1995c . Decrease in cytochrome P4502E1 as assessed by the rate of chlorzoxazaone hydroxylation in alcoholics during the withdrawal phase . Alcohol. Clin. Exp. Res. , 19 : 362 – 366 .
  • Lucas , D. , Menez , J. and Berthou , F. 1996a . Chlorzoxazaone: An in vitro and in vivo substrate probe for liver CYP2E1 . Methods Enzymol. , 272 : 115 – 123 .
  • Lucas , D. , Menez , C. , Floch , F. , Gourlaouen , Y. , Sparfel , O. , Joannet , I. , Bodenez , P. , Jezequel , J. , Gouerou , H. , Berthou , F. , Bardou , L. and Menez , J. 1996b . Cytochromes P4502E1 and P4501A1 genotypes and susceptibility to cirrhosis or upper aerodigestive tract cancer in alcoholic Caucasians . Alcohol. Clin. Exp. Res. , 20 : 1033 – 1037 .
  • Maezawa , Y. , Yamauchi , M. and Toda , G. 1994 . Association between restriction fragment length polymorphism of the human cytochrome p450IIE1 gene and susceptibility to alcoholic liver cirrhosis . Am. J. Gastroenterol. , 89 : 561 – 565 .
  • Martinez , C. , Agundez , J. , Olivera , M. , LLerena , A. , Ramirez , R. , Hernandez , M. and Benitez , J. 1998 . Influence of genetic admixture on polymorphisms of drug metabolizing enzymes: Analyses of mutations on NAT2 and Cyp2E1 genes in a mixed Hispanic population . Clin. Pharmacol. Ther. , 63 : 623 – 628 .
  • Matthias , C. , Bockmuhl , U. , Jahnke , V. , Hones , P. , Hayes , J. , Alldersea , J. , Gilford , J. , Bailey , L. , Bath , J. , Worrall , S. , Hand , P. , Fryer , A. and Strange , R. 1998 . Polymorphism in cytochrome P450 CYP2D6, CYP1A1, CYP2E1 and glutathione S-transferase, GSTM1, GSTM3, GSTT1 and susceptibility to tobacco-related cancers: Studies in upper aerodigestive tract cancers . Pharmacogenetics , 8 : 91 – 100 .
  • McBride , O. W. , Umeno , M. , Gelboin , H. V. and Gonzalez , F. J. 1987 . A Taq I polymorphism in the human P450IIE1 gene on chromosome 10 (CYP2E) . Nucleic Acids Res. , 15 : 10071
  • McCarver , D. , Byun , R. , Hines , R. , Hichme , M. and Wegenek , W. A. 1998 . Genetic polymorhism in the regulatory sequences of human Cyp2e1: Association with increased chlorzoxazone hydroxylation in the presence of obesity and ethanol intake . Toxicol. Appl. Pharmacol. , 152 : 276 – 281 .
  • Miller , K. and Yang , C. 1984 . Studies on the mechanisms of induction of N-nitrosodimethylamine demethylase by fasting, acetone and ethanol . Arch. Biochem. Biophys. , 229 : 483 – 491 .
  • Mishin , V. , Koivisto , T. and Lieber , C. 1996 . The determination of cytochrome P-450 2E1 dependent p-nitrophenol hydroxylation by high performance liquid chromatography with electrochemical dectection . Anal. Biochem. , 233 : 212 – 215 .
  • Morgan , E. T. , Koop , D. R. and Coon , M. J. 1983 . Comparison of six rabbit cytochrome P-450 isozymes in formation of a reactive metabolite of acetaminophen . Biochem. Biophys. Res. Commun. , 112 : 8 – 13 .
  • Morita , S. , Yano , M. , Shiozaki , H. , Tsujinaka , T. , Ebisui , C. , Morimoto , T. , Kishibuti , M. , Fujita , J. , Ogawa , A. , Taniguchi , M. , Inoue , M. , Tamura , S. , Yamazoki , K. , Kikkawa , N. , Mizunoya , S. and Monden , M. 1997 . CYP1A1, CYP2E1 and GSTM1 polymorphisms are not associated with susceptibility to squamous cell carcinoma of the esophagus . Int. J. Cancer , 71 : 192 – 195 .
  • Nakamura , K. , Iwahashi , K. , Matsuo , Y. , Miyatake , R. and Ichikawa , Y. 1996 . Characteristic of Japanese alcoholics with the atypical aldehydrogenase 2∗2. I. A comparison of the genotypes of ALDH2, ADH2, ADH3 and cytochrome P4502E1 between alcoholics and non-alcoholics . Alcohol. Clin. Exp. Res. , 20 : 52 – 55 .
  • Nedelcheva , V. , Gut , I. , Soucek , P. , Tichavska , B. , Tynkova , L. , Mraz , J. , Guengerich , F. and Ingelman-Sundberg , M. 1999 . Metabolism of benzene in human liver microsomes: individual variations in relation to CYP2E1 expression . Arch. Toxicol. , 73 : 33 – 40 .
  • Nelson , S. D. 1990 . Molecular mechanisms of the hepatotoxicity caused by acetaminophen . Semin. Liver Dis. , 10 : 267 – 278 .
  • Ohnishi , K. and Lieber , S. 1977 . Reconstitution of the microsomal ethanol oxidizing system (MEOS): Qualitative and quantitative changes of cytochrome P-450 after chronic ethanol consumption . J. Biol. Chem. , 252 : 7124 – 7131 .
  • Ono , S. , Hatanaka , T. , Hotta , H. , Tsusui , M. , Satoh , T. and Gonzalez , F. 1995 . Chlorzoxazone is metabolized by human CYP1A2 as well as human CYP2E1 . Pharmacogenetics , 5 : 143 – 150 .
  • O'Shea , D. , Davis , S. , Kim , R. and Wilkinson , G. 1994 . Effect of fasting and obesity in humans on the 6-hydroxylation of chlorzoxazone: A putative probe of CYP2E1 activity . Clin. Pharmacol. Ther. , 56 : 359 – 367 .
  • Oyama , T. , Kawamoto , T. , Mizoue , T. , Sugio , K. , Kodama , Y. , Mitsudomi , T. and Yasumoto , K. 1997 . Cytochrome P4502E1 polymorphism as a risk factor for lung cancer: in relation to p53 gene mutation . Anticancer Res. , 17 : 583 – 588 .
  • Pasanen , M. and Pelkonen , O. 1994 . The expression and environmental regulation of P450 enzymes in human placenta . Crit. Rev. Toxicol. , 24 : 211 – 229 .
  • Perrot , N. , Nalpas , B. , Yang , C. and Beaune , P. 1989 . Modulation of cytochrome P450 isozymes in human liver by ethanol and drug intake . Eur. J. Clin. Invest. , 19 : 549 – 555 .
  • Persson , I. , Terelius , Y. and Ingelman-Sundberg , M. 1990 . Cytochrome P-450-dependent formation of reactive oxygen radicals; Isozyme-specific inhibition of P-450 mediated reduction of oxygen and carbon tetrachloride . Xenobiotica , 20 : 887 – 900 .
  • Persson , I. , Johansson , I. , Bergling , H. , Dahl , M. , Seidegard , J. , Rylander , R. , Rannug , A. , Hogberg , J. and Ingelman-Sundberg , M. 1993 . Genetic polymorphism of cytochrome P4502E1 in a Swedish population. Relationship to incidence of lung cancer . FEBS Lett. , 319 : 207 – 211 .
  • Peter , R. , Bocker , R. , Beaune , P. , Iwasaki , M. , Guengerich , F. and Yang , C. 1990 . Hydroxylation of chlorzoxazone as a specific probe for human liver cytochrome P450IIEI . Chem. Res. Toxicol. , 3 : 566 – 573 .
  • Peter , R. , Bocker , R. , Beaune , P. H. , Iwasaki , M. , Guengerich , F. P. and Yang , C. S. 1991 . Hydroxylation of chlorzoxazone as a specific probe for human liver cytochrome P-450IIE1 . Chem. Res. Toxicol. , 3 : 566 – 573 .
  • Pirmohamed , M. , Quest , K. , Kitteringham , N. , Allott , R. , Gilmore , I. and Park , B. 1994 . Association between cytochrome P450 2E1 (CYP2E1) restriction fragment length polymorphism and alcoholic liver disease in Caucasians . Hepatology , 20 : 317A
  • Porter , T. , Khani , S. and Coon , M. 1989 . Induction and tissue specific expression of rabbit cytochrome P-450IIE1 and IIE2 genes . Mol. Pharmacol. , 36 : 61 – 65 .
  • Powell , H. , Kitteringham , N. , Pirmohamed , M. , Smith , D. and Park , B. 1998 . Expression of cytochrome P4502E1 in human liver: assessment by mRNA, genotype, and phenotype . Pharmacogenetics , 8 : 411 – 421 .
  • Raucy , J. , Lasker , J. , Kramer , J. , Salazer , D. , Lieer , C. and Corcoran , G. 1991 . Induction of P-450IIE1 in the obese rat . Mol. Pharmacol. , 39 : 275 – 280 .
  • Raucy , J. L. , Kraner , J. C. and Lasker , J. M. 1993 . Bioactivation of halogenated hydrocarbons by cytochrome P4502E1 . Crit. Rev. Toxicol. , 23 : 1 – 20 .
  • Reinke , L. , Lai , E. and McCay , P. 1988 . Ethanol feeding stimulates trichlormethyl radical formation from carbon tetrachloride in liver . Xenobiotica , 18 : 1311 – 1318 .
  • Rihs , H. P. , Triebig , G. , Werner , P. , Rabstein , S. , Heinze , E. , Pesch , B. and Bruning , T. 2008 . Association between genetic polymorphisms in styrene-metabolizing enzymes and biomarkers in styrene-exposed workers . J. Toxicol. Environ. Health A , 71 : 866 – 873 .
  • Ronis , M. J. J. , Huang , J. , Crouch , J. , Mercado , C. , Irby , D. , Valentine , C. R. , Lumpkin , C. K. , Ingelman-Sundberg , M. and Badger , T. M. 1993 . Cytochrome P450 2E1 induction during chronic ethanol exposure occurs by a two step mechanism associated with blood alcohol concentrations in rats . J. Pharmacol. Exp. Ther. , 264 : 944 – 950 .
  • Ryan , D. E. , Ramanathan , L. , Iida , S. , Thomas , PE. , Haniu , M. , Shively , J. E. , Lieber , C. S. and Levin , W. 1985 . Characterization of a major form of rat hepatic microsomal cytochrome P-450 induced by isoniazid . J. Biol. Chem. , 260 : 6385 – 6393 .
  • Ryan , D. and Levin , W. 1990 . Purification and characterization of hepatic microsomal cytochrome P-450 . Pharmacol. Ther. , 45 : 153 – 239 .
  • Sakurai , K. and Cederbaum , A. 1998 . Oxidative stress and cytotoxicity induced by ferric-nitrilotriacetate in HepG2 cells that express cytochrome P450 2E1 . Mol. Pharmacol. , 54 : 1024 – 1035 .
  • Salazar , D. , Sorge , C. and Corcoran , G. 1988 . Obesity as a risk factor for drug-induced organ injury. VI. Increased hepatic P-450 concentration and microsomal ethanol oxidizing activity in the obese overfed rat . Biochem. Biophys. Res. Commun. , 157 : 315 – 320 .
  • Sai , Y. , Yang , T. , Krausz , K. , Gonzalez , F. and Gelboin , H. 1999 . An inhibitory monoclonal antibody to human cytochrome P450 2A6 defines its role in the metabolism of coumarin, 7-ethoxycoumarin and 4-nitroanisole in human liver . Pharmacogenetics , 9 : 229 – 237 .
  • Saito , K. , Yamazoe , Y. , Kamataki , T. and Kato , R. 1983 . Activation and detoxification of N-hydroxy-Tryp-P-2 by glutathione transferases . Carcinogenesis (Lond.) , 4 : 1551 – 1557 .
  • Sangrajrang , S. , Jedpiyawongse , A. and Srivatanakul , P. 2006 . Genetic polymorphisms of CYP2E1 and GSTM1 in a Thai population . Asian Pacific J. Cancer Prev. , 7 : 415 – 419 .
  • Sato , M. and Lieber , C. 1981 . Hepatic vitamin A depletion after chronic ethanol consumption in baboons and rats . J. Nutr. , 111 : 2015 – 2023 .
  • Schindler , J. , Li , Y. , Marion , M. J. , Paroly , A. and Brandt-Rauf , P. W. 2007 . The effect of genetic polymorphisms in the vinyl chloride metabolic pathway on mutagenic risk . J. Hum. Genet. , 52 : 448 – 455 .
  • Shi , S. , Wang , Z. , Smith , T. , Hong , J. , Chen , W. , Ho , C. and Yang , C. 1994 . Effects of green tea and black tea on 4-(methynitrosamino)-1-(3-pyridyl)-1-butanone bioactivation, DNA methylation and lung tumorigenesis I A/J mice . Cancer Res. , 54 : 4641 – 4647 .
  • Shields , P. , Ambrosone , C. , Graham , S. , Bowman , E. , Harrington , A. , Gillenwater , K. , Marshall , J. , Vena , J. , Laughlin , R. , Nemoto , T. and Freudenheim , J. 1996 . A cytochrome P4502E1 genetic polymorphism and tobacco smoking in breast cancer . Mol. Carcinogen. , 17 : 144 – 150 .
  • Shimada , T. , Yamazaki , H. , Mimura , M. , Inui , Y. and Guengerich , F. 1994 . Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: Studies with liver microsomes of 30 Japanese and 30 Caucasians . J. Pharmacol. Exp. Ther. , 270 : 414 – 423 .
  • Shimada , T. , Tsumura , F. and Yamazaki , H. 1999 . Prediction of human liver microsomal oxidations of 7-ethoxycoumarin and chlorzoxazone with kinetic parameters of recombinant cytochrome P-450 enzymes . Drug Metab. Dispos. , 27 : 1274 – 1280 .
  • Shows , T. B. , McAlpine , P. J. , Boucheix , C. , Collins , F. S. , Conneally , P. M. , Frezal , J. , Gershowitz , H. , Goodfellow , P. N. , Hall , J. G. , Issitt , P. , Jones , C. A. , Knowles , B. B. , Lewis , M. , McKusick , V. A. , Meisler , M. , Morton , N. E. , Rubenstein , P. , Schanfield , M. S. , Schmickel , R. D. , Skolnick , M. H. , Spence , M. A. , Sutherland , G. R. , Traver , M. , Vancong , N. and Willard , H. F. 1987 . Guidelines for human gene nomenclature. An international system for human gene nomenclature . Cytogenet. Cell Genet. , l46 : 11 – 28 .
  • Snyder , R. and Hedli , C. 1996 . An overview of benzene metabolism . Environ. Health Perspect. , 104 ( suppl. 6 ) : 1165 – 1171 .
  • Song , B. , Gelboin , H. , Park , S. , Yang , C. and Gonzalez , F. 1986 . Complementary DNA and protein sequences of ethanol inducible rat and human cytochrome P-450s: Transcriptional and posttranscriptional regulation of the rat enzyme . J. Biol. Chem. , 261 : 16689 – 16697 .
  • Song , B. , Matsunaga , T. , Hardwick , J. , Park , S. , Veech , R. , Yang , C. , Gelboin , H. and Gonzalez , F. 1987 . Stabilization of cytochrome P-450J messenger ribonucleic acid in the diabetic rat . Mol. Endocrinol. , 1 : 542 – 547 .
  • Song , B. , Veech , R. , Park , S. , Gelboin , H. and Gonzalez , F. 1989 . Induction of rat hepatic N-nitrosodimethylamine demethylase by acetone is due to protein stabilization . J. Biol. Chem. , 264 : 3568 – 3572 .
  • Song , B. , Veech , R. and Saenger , P. 1990 . Cytochrome P-450IIEI is elevated in lymphocytes from poorly controlled insulin dependent diabetics . J. Clin. Endocrinol. Metab. , 71 : 1036 – 1040 .
  • Stephens , E. , Taylor , J. , Kaplan , N. , Yang , C. , Hsieh , L. , Lucier , G. and Bell , D. 1994 . Ethnic variation in the CYP2E1 gene: Polymorphism analysis of 695 African-Americans, European-Americans and Taiwanese . Pharmacogentics , 4 : 185 – 192 .
  • Stubbins , M. and Wolf , C. 1999 . “ Additional polymorphisms and cancer ” . In Metabolic polymorphisms and susceptibility to cancer , Edited by: Ryder , W. 271 – 302 . Lyon : International Agency for Research on Cancer . IARC Scientific Publication No. 148
  • Sugimura , H. , Hamada , G. , Suzuki , I. , Iwase , T. , Kiyokawa , E. , Kino , I. and Tsugane , S. 1995 . CYP1A1 and CYP2E1 polymorphism and lung cancer, case control study in Rio de Janeiro, Brazil . Pharmacogenetics , 5 : S145 – S148 .
  • Takahashi , T. , Lasker , J. , Rosman , A. and Lieber , C. 1993 . Induction of cytochrome P-4502E1 in the human liver by ethanol is caused by a corresponding increase in encoding messenger RNA . Hepatology , 17 : 236 – 245 .
  • Tanaka , E. 1998 . In vivo age-related changes in hepatic drug-oxidizing capacity in humans . J. Clin. Pharmacol. Ther. , 23 : 247 – 255 .
  • Tan , W. , Song , N. , Wang , G. , Liu , Q. , Tang , H. , Kadlubar , F. and Lin , D. 2000 . Impact of genetic polymorphisms in cytochrome P4502E1 and GST M1, T1, and P1 on susceptibility to esophageal cancer among high risk individuals in China . Cancer Epidemiol. Biomarkers Prev. , 9 : 551 – 556 .
  • Tassaneekyakul , W. , Veronese , M. , Birkett , D. , Gonzalez , F. and Miners , J. 1993 . Validation of 4-nitrophenol as an in vitro substrate probe for human liver CYP2E1 using cDNA expression and microsomal kinetic techniques . Biochem. Pharmacol. , 46 : 1975 – 1981 .
  • Terelius , Y. , Nersten-Hoog , C. , Cronholm , T. and Ingerman-Sundberg , M. 1991 . Acetaldehyde as a substrate for ethanol-inducible cytochrome P450 (CYP2E1) . Biochem. Biophys. Res. Commun. , 179 : 689 – 694 .
  • Teschke , R. , Moreno , F. and Petrides , A. 1981 . Hepatic microsomal ethanol oxidizing system (MEOS): Respective roles of ethanol and carbohydrates for the enhanced activity after chronic alcohol consumption . Biochem. Pharmacol. , 30 : 1745 – 1751 .
  • Thomasson , H. , Edenber , J. , Crabb , D. , Mai , X. , Jerome , R. , Li , T. , Wang , S. , Lin , Y. , Lu , R. and Yin , S. 1991 . Alcohol and aldehyde dehydrogenase genotypes and alcoholism in Chinese men . Am. J. Hum. Genet. , 48 : 677 – 681 .
  • Togawa , H. , Shinkai , S. and Mizutani , T. 2008 . Induction of human UGT1A1 by bilirubin through AhR dependent pathway . Drug Metab. Lett. , 2 : 231 – 237 .
  • Trichopoulos , D. , Lagiou , P. , Trichopoulou , A. and Trichopoulos , D. 2002 . Nutritional epidemiology of cancer: accomplishments and prospects . Proc. Nutr. Soc. , 61 : 217 – 222 .
  • Tsutsumi , M. , Lasker , J. , Shimizi , M. , Rosman , A. and Lieber , C. 1989 . The intralobular distribution of ethanol-inducible P450 IIEI in rat and human liver . Hepatology , 10 : 437 – 446 .
  • Tsutsumi , M. , Matsuda , Y. and Takada , A. 1993 . Role of ethanol-inducible cytochrome P-450 2E1 in the development of hepatocellular carcinoma by the chemical carcinogen N-nitrosodemethylamine . Hepatology , 18 : 1483 – 1489 .
  • Tsutsumi , M. , Takada , A. and Wang , J. 1994 . Genetic polymorphisms of cytochrome P4502E1 related to the development of alcoholic liver disease . Gastroenterology , 107 : 1430 – 1435 .
  • Uchimoto , T. , Itoga , S. , Nezu , M. , Sunaga , M. , Tomonaga , T. and Nomura , F. 2007 . Role of the genetic polymorphisms in the 5’ flanking region for transcriptional regulation of the human CYP2E1 gene . Alcohol. Clin. Exp. Res. , 31 : 36S – 42S .
  • Uematsu , F. , Tsutsumi , M. , Takase , S. , Matsuda , Y. and Kawahara , H. 1991 . Association between restriction fragment length polymorphism of the human cytochrome P4502E1 gene and susceptibility to lung cancer . Jpn. J. Cancer Res. , 82 : 254 – 256 .
  • Uematsu , F. , Ikawa , S. , Kikuchi , H. , Sagami , I. , Kanamaru , R. , Abe , T. , Satoh , K. , Motomiya , M. and Watanabe , M. 1994 . Restriction fragment length polymorphism of the human CYP2E1 (cytochrome P450IIEI) gene and susceptibility to lung cancer: possible relation to low smoking exposure . Pharmacogenetics , 4 : 58 – 63 .
  • Ueshima , Y. , Tsutsumi , M. , Takase , S. , Matsuda , Y. and Yawahara , H. 1996 . Acetaminophen metabolism in patients with different cytochrome P4502E1 genotypes . Alcohol. Clin. Exp. Res. , 20 : 25A – 28A .
  • Umbenhauer , D. , Wild , C. P. , Montesano , R. , Saffhill , R. , Boyle , J. M. , Huh , N. , Kirstein , U. , Thomale , J. , Rajewsky , M. F. and Lu , S. H. 1985 . O(6)-Methyldeoxyguanosine in oesophageal DNA among individuals at high risk of oesophageal cancer . Int. J. Cancer , 36 : 661 – 665 .
  • Vieira , I. , Sonnier , M. and Crestiel , T. 1996 . Developmental expression of CYP2E1 in the human liver. Hypermethylation control of gene expression during the neonatal period . Eur. J. Biochem. , 238 : 476 – 483 .
  • Watanabe , J. , Hayashi , S. , Nakachi , K. , Imai , K. , Suda , Y. , Sekine , T. and Kawajiri , K. 1990 . PstI and RsaI RFLPs in complete linkage disequilibrium at the CYP2E gene . Nucleic Acids Res. , 18 : 7194
  • Watanabe , J. , Hayashi , S. and Nakachi , K. 1994 . Different regulation and expression of the human CYP2E1 gene due to Rsa I polymorphism in the 5’-flanking region . J. Biochem. , 116 : 321 – 326 .
  • Watanabe , J. , Yang , JP. , Eguchi , H. , Hayashi , S. , Imai , K. , Nakachi , K. and Kawajiri , K. 1995 . An Rsa I polymorphism in the CYP2E1 gene does not affect lung cancer risk in a Japanese population . Jpn. J. Cancer Res. , 86 : 245 – 248 .
  • Wattenberg , L. 1992 . Inhibition of carcinogenesis by minor dietary constituents . Cancer Res. , 52 : 2085s – 2091s .
  • Wrighton , S. , Thomas , P. , Molowa , D. , Haniu , M. , Shively , J. , Maines , S. , Watkins , P. , Parker , G. , Mendez-Picon , G. , Levin , W. and Guzelian , P. 1986 . Characterization of ethanol-inducible human liver N-nitrosodimethylamine demethylase . Biochemistry , 25 : 6731 – 6735 .
  • Wu , D. , Clejan , L. , Potter , B. and Cederbaum , A. 1990 . Rapid decrease of cytochrome P-450IIE1 in primary hepatocyte culture and its maintenance by added 4-methylpyrazole . Hepatocyte , 6 : 1379 – 1389 .
  • Wu , X. , Shi , H. , Jiang , H. , Kemp , B. , Hong , W. K. , Delclos , G. L. and Spitz , M. R. 1997 . Associations between cytochrome P4502E1 genotype, mutagen sensitivity, cigarette smoking and susceptibility to lung cancer . Carcinogenesis , 18 : 967 – 973 .
  • Wu , X. , Amos , C. , Kemp , B. , Shi , H. , Jiang , H. , Wan , Y. and Spitz , M. 1998 . Cytochrome P4502E1 DraI polymorphisms in lung cancer in minority populations . Cancer Epidemiol. Biomarkers.Prev. , 7 : 13 – 18 .
  • Yamazaki , H. , Guo , Z. and Guengerich , FP. 1995 . Selectivity of cytochrome P4502E1 in chlorzoxazone 6-hydroxylation . Drug Metab. Dispos. , 23 : 438 – 440 .
  • Yamazaki , H. , Inoue , K. , Mimura , M. , Oda , Y. , Guengerich , F. and Shimada , T. 1996 . 7-Ethoxycoumarin O-deethylation catalyzed by cytochromes P450 1A2 and 2E1 in human liver microsomes . Biochem. Pharmacol. , 51 : 313 – 319 .
  • Yamazaki , H. and Shimada , T. 2006 . Cytochrome P450 reconstitution systems . Methods Mol. Biol. , 320 : 61 – 71 .
  • Yang , C. and Smith , T. 1996 . Mechanisms of nitrosamine bioactivation and carcinogenesis . Adv. Exp. Med. Biol. , 387 : 385 – 394 .
  • Yang , C. , Yoo , J. , Ishizaki , H. and Hong , J. 1990 . Cytochrome P-450IIEI: Roles in nitrosamine metabolism and mechanisms of regulation . Drug Metab. Rev. , 22 : 147 – 159 .
  • Yang , T. , Krausz , K. , Sai , Y. , Gonzalez , F. and Gelboin , H. 1999 . Eight inhibitory monoclonal antibodies define the role of individual P-450s in human liver microsomal diazepam, 7-ethoxycoumarin, and imipramine metabolism . Drug Metab. Dispos. , 27 : 102 – 109 .
  • Yoo , J. , Guengerich , F. and Yang , C. 1988 . Metabolism of N-nitosodialkylamines by human liver microsomes . Cancer Res. , 48 : 1499 – 1504 .
  • Yu , M. , Gladek-Yarborough , A. , Chiamprasert , S. , Santella , R. , Liaw , Y. and Chen , C. 1995 . Cytochrome P-450 2E1 and glutathione S-transferase M1 polymorphisms and susceptibility to hepatocellular carcinoma . Gastroenterology , 109 : 1266 – 1273 .
  • Yun , Y. , Casazza , J. , Sohn , D. , Veech , R. and Song , B. 1992 . Pretranslational activation of cytochrome P-450IIE1 during ketosis induced by a high fat diet . Mol. Pharmacol. , 41 : 474 – 479 .
  • Zand , R. , Nelson , S. , Slattery , J. , Thummel , K. , Kalhorn , T. , Adams , S. and Wright , J. 1993 . Inhibition and induction of cytochrome P-4502E1 catalyzed oxidation by isoniazid in humans . Clin. Pharmacol. Ther. , 54 : 142 – 149 .

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