A New Fibrin Sealant From Crotalus durissus terrificus Venom: Applications in Medicine

REFERENCES

• Alexander , A. , Grothusen , J. , Zepeda , H. and Schwartzman , R. J. 1988 . Gyroxin a toxin from the venom of Crotalus durissus terrificus, is a thrombin-like enzyme . Toxicon , 26 : 953 – 960 .
   PubMed Web of Science ®Google Scholar
• Alving , B. M. , Weinstein , M. J. , Finlaynson , J. S. , Menitone , J. E. and Fratantoni , J. C. 1995 . Fibrin sealant: Summary of a conference on characteristics and clinical uses . Transfusion , 35 : 783 – 790 .
   PubMed Web of Science ®Google Scholar
• Ambacher , T. , Kuhn , P. , Schmidth , R. , Disselhorst-Klug , C. and Paar , O. 2001 . Muscle strength and functional results after surgical repair of Achilles tendon rupture with fibrin gluing . Zentrlbl. Chir. , 126 : 989 – 994 .
   Google Scholar
• Antonelli , M. , Cicconetti , F. , Vivino , G. and Gasparetto , A. 1991 . Closure of tracheoesophageal fistulas by bronchoscopic application of fibrin glue and decontamination of the oral cavity . Chest , 100 : 578 – 579 .
   PubMed Web of Science ®Google Scholar
• Banninger , H. , Hardegger , T. , Tobler , A. , Barth , A. , Schupbach , P. , Reinhart , W. , Lammle , B. and Furlan , M. 1993 . Fibrin glue in surgery: Frequent development of inhibitors of bovine thrombin and human factor V . Br. J. Haematol. , 85 : 528 – 532 .
   PubMed Web of Science ®Google Scholar
• Barbosa , M. D. S. , Greghi , S. L. A. and Passanezi , E. 2007 . Fibrin adhesive derived from snake venom in periodontal surgery . J. Periodontol. , 78 : 2026 – 2031 .
   Google Scholar
• Barbosa , M. D. S. , Stipp , A. C. , Passanezi , E. and Greghi , L. A. 2008 . Fibrin adhesive derived from snake venom in periodontal surgery. Histological analysis . J. Appl. Oral Sci. , 16 : 310 – 315 .
   Google Scholar
• Bar-Hava , I. , Krissi , H. , Ashkenazi , J. , Orvieto , R. , Shelef , M. and Ben-Rafael , Z. 1999 . Fibrin glue improves pregnancy rates in women of advanced reproductive age and in patients in whom in vitro fertilization attempts repeatedly fail . Fertil. Steril. , 71 : 821 – 824 .
   PubMed Web of Science ®Google Scholar
• Barrio , A. 1961 . Gyroxin, a new neurotoxin of Crotalus durissus terrificus venom . Acta Physiol Latin Am. , 11 : 224 – 232 .
   Google Scholar
• Bergel , S. 1909 . Uber wirkungen des fibrins . Dtsh. Med. Wochenschr. , 35 : 633 – 665 .
   Google Scholar
• Biedner , B. and Rosenthal , G. 1996 . Conjunctival closure in strabismus surgery: Vicryl versus fibrin glue . Ophthalmic Surg. Lasers , 27 : 967
   PubMedGoogle Scholar
• Borst , H. G. , Haverich , A. , Walterbush , G. and Maatz , W. 1982 . Fibrin adhesive: an important hemostatic adjunct in cardiovascular operations . J. Thoracic Cardiovasc. Surg. , 84 : 548 – 553 .
   PubMed Web of Science ®Google Scholar
• Braud , S. , Bon , C. and Wisner , A. 2000 . Snake venom acting on haemostasis . Biochimie , 82 : 851 – 859 .
   PubMedGoogle Scholar
• Brega Massone , P. P. , Magnani , B. , Conti , B. , Lequaglie , C. and Cataldo , I. 2003 . Cauterization versus fibrin glue for aerostasis in precision for secondary lung tumors . Ann. Surg. Oncol. , 10 : 441 – 446 .
   Google Scholar
• Brennan , M. 1991 . Fibrin glue . Blood Rev. , 5 : 240 – 244 .
   PubMed Web of Science ®Google Scholar
• Chiquito , G. C. M. 2007 . Comparison between suture and fibrin adhesive derived from snake venom for fixation of connective tissue graft in correction of marginal tissue recession . J. Venom Anim. Toxins Trop. Dis. , 13 : 559
   Google Scholar
• Cintron , J. R. , Park , J. J. , Orsay , C. P. , Pearl , R. K. , Nelson , R. L. , Sone , J. H. , Song , R. and Abcarian , H. 2000 . Repair of fistulas-in-ano using fibrin-adhesive: Long-term follow-up . Dis. Colon Rectum , 43 : 944 – 949 .
   PubMed Web of Science ®Google Scholar
• Costa , F. L. S. , Rodrigues , R. S. , Izidoro , L. F. M. , Menaldo , D. L. , Hamaguchi , A. , Homsi-Brandeburgo , M. I. , Fuly , A. L. , Soares , S. G. , Selistre-de-Araújo , H. S. , Barraviera , B. , Soares , A. M. and Rodrigues , V. M. 2009 . Biochemical and functional properties of a thrombin-like enzyme isolated from Bothrops pauloensis snake venom . Toxicon , 54 : 725 – 735 .
   Google Scholar
• Cronkite , E. P. , Lozner , E. L. and Deaver , J. M. 1944 . Use of thrombin and fibrinogen in skin grafting . J. Am. Med. Assoc. , 124 : 976 – 978 .
   Google Scholar
• Ellis , R. A. and Levine , A. M. 1963 . Experimental suture-less ocular surgery . Am J Ophthalmol. , 55 : 733 – 741 .
   Google Scholar
• Endo , M. and Kurosawa , H. 2004 . Left ventricular free wall rupture . Kyobu Geka , 57 : 690 – 697 .
   Google Scholar
• Esmon , C. T. 2000 . Regulation of blood coagulation . Biochim. Biophys. Acta , 1477 : 349 – 360 .
   PubMed Web of Science ®Google Scholar
• Evans , L. A. , Ferguson , K. H. , Foley , J. , Rozanski , T. A. and Morey , A. F. 2003 . Fibrin sealant for the management of genitourinary injuries, fistulas and surgical complications . J. Urol. , 169 : 1360 – 1362 .
   Web of Science ®Google Scholar
• Fattahi , T. , Mohan , M. and Caldwell , G. T. 2004 . Clinical applications of fibrin sealants . J. Oral Maxillofacial Surg. , 62 : 218 – 224 .
   Google Scholar
• Ferraro , G. C. , Moraes , J. R. E. , Shimano , A. C. , Pereira , G. T. , Moraes , F. R. and Bueno de Camargo , M. H. 2005a . Effect of snake venom derived fibrin glue on the tendon healing in dogs. Clinical and biomechanical study . J. Venom. Anim. Toxins Trop. Dis. , 11 : 261 – 274 .
   Google Scholar
• Ferraro , G. C. , Moraes , J. R. E. , Pereira , G. T. , Moraes , F. R. and Bueno de Camargo , M. H. 2005b . Clinical and morphological evaluation of snake venom derived of fibrin glue tendon healing in dogs . J. Venom. Anim. Toxins Trop. Dis. , 11 : 433 – 446 .
   Google Scholar
• Ferreira , R. S. Jr. , Alves , J. B. , Couto , R. , Meira , D. A. , Nascimento , N. and Barraviera , B. 2006 . Laboratory evaluation of young ovines inoculated with natural or 60Co-irradiated Crotalus durissus terrificus venom during hyperimmunization process . J. Venom. Anim. Toxins Trop. Dis. , 12 : 620 – 631 .
   Google Scholar
• Fezza , J. P. , Cartwright , M. , Mack , W. and Flaherty , P. 2002 . The use of aerosolized fibrin glue in face-lift surgery . Plastic Reconstr. Surg. , 110 : 658 – 664 .
   Google Scholar
• Flemming , I. 1992 . Fibrin glue in face-lifts . Facial Plastic Surg. , 8 : 79 – 88 .
   Google Scholar
• Gatti , M. A. N. 2009 . Treatment of venous ulcers with surgical adhesive derived from snake venom . J. Venom. Anim. Toxins Trop. Dis. , 15 : 368
   Google Scholar
• Gestring , G. F. and Lerner , R. 1983 . Autologous fibrin for tissue-adhesion, haemostasis and embolization . Vasc. Surg. , 17 : 294 – 304 .
   Google Scholar
• Glover , W. , Chavis , T. V. , Daniel , T. M. , Kron , I. L. and Spotnitz , W. D. 1987 . Fibrin glue application through the fiberoptic bronchoscope. Closure of bronchopleural fistulase . J. Thoracic Cardiovasc. Surg. , 93 : 470 – 472 .
   PubMed Web of Science ®Google Scholar
• Greco , F. , Depalma , L. , Spagnolo , N. , Rossi , A. , Specchia , N. and Gigante , A. 1991 . Fibrin-antibiotic mixtures: An in vitro study assessing the possibility of using a biological carrier for local drug delivery . J. Biomed. Mater. Res. , 25 : 39 – 51 .
   PubMed Web of Science ®Google Scholar
• Grey , E. G. 1915 . Fibrin as a hemostatic in cerebral surgery . Surg. Gynecol. Obstet. , 21 : 452 – 454 .
   Google Scholar
• Grossman , J. A. , Capraro , P. A. and Burneikis , V. 2001 . Minimizing complications in the use of fibrin sealant in aesthetic facial procedures . Anesth. Surg. J. , 21 : 32 – 39 .
   Google Scholar
• Halfpenny , W. , Fraser , J. S. and Adlam , D. M. 2001 . Comparison of 2 hemostatic agents for the prevention of postextraction hemorrhage in patients on anticoagulants . Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endodontol. , 92 : 257 – 259 .
   Google Scholar
• Hansen , M. K. , Kruse-Andersens , S. and Watt-Boolsen , S. 1989 . Spontaneous pneumothorax and fibrin sealant during thoracoscopy . Eur. J. Cardiothoracic Surg. , 3 : 512 – 514 .
   Google Scholar
• Hashimoto , J. , Kusosaka , M. , Yoshiya , S. and Hirohata , K. 1992 . Meniscal repair using fibrin sealant and endotelial cell growth factor. An experimental study in dogs . Am. J. Sports Med. , 20 : 537 – 541 .
   Google Scholar
• Heneghan , M. A. , Byrne , A. and Harrison , P. M. 2002 . An open pilot study of the effects of a human fibrin glue for endoscopic treatment of patients with acute bleeding from gastric varices . Gastrointestinal Endosc. , 56 : 422 – 426 .
   Google Scholar
• Hillerdal , G. , Gustafsson , G. and Wegenitus , G. 1995 . Large emphysematous bullae. Successful treatment with thorascopic technique using fibrin glue in poor-risk pacients . Chest , 107 : 1450 – 1453 .
   PubMed Web of Science ®Google Scholar
• Hino , M. , Ishiko , O. , Honda , K. I. , Yamane , T. , Ohta , K. , Takubo , T. and Tatsumi , N. 2000 . Transmission of symptomatic parvovirus B19 infection by fibrin sealant used during surgery . Br. J. Haematol. , 108 : 194 – 195 .
   PubMed Web of Science ®Google Scholar
• Ishitani , M. B. , Mcgahren , E. D. , Sibley , D. A. , Spotnitz , W. D. and Rodgers , B. M. 1989 . Laparoscopically applied fibrin glue in experimental liver trauma . J. Pediatr. Surg. , 24 : 867 – 871 .
   PubMed Web of Science ®Google Scholar
• Israels , S. J. and Israels , E. D. 1994 . Development of antibodies to bovine and human factor V in two children after exposure to topical bovine thrombin . Am. J. Pediatr. Hematol. Oncol. , 16 : 249 – 254 .
   PubMedGoogle Scholar
• Iuan , F. C. , Thomazini , I. A. , Giannini , M. J. M. , Viterbo , F. , Toscano , E. , Moraes , R. A. and Barraviera , B. 1995 . Reparation of peripheral nerves with fibrin glue prepared from snake venom. Preliminary results . São Paulo Med. J. , 113 : 1000 – 1002 .
   Google Scholar
• Iwaya , K. , Mizoi , K. , Tessler , A. and Itoh , Y. 1999 . Neurotrophic agents in fibrin glue mediate adult dorsal root regeneration into spinal cord . Neurosurgery , 44 : 589 – 595 .
   PubMed Web of Science ®Google Scholar
• Jia , Y. H. , Jin , Y. , Lü , Q. M. , Li , D. S. , Wang , W. Y. and Xiong , Y. L. 2003 . Jerdonase, a novel serine protease with kini-realising and fibrinogenolytic activity from Trimeresurus jerdonii venom . Acta Biochim. Biophys. Sin. , 359 : 689 – 694 .
   Google Scholar
• Kassam , A. , Horowitz , M. , Carrau , K. , Snyderman , C. , Welch , W. , Hirsch , B. and Chang , Y. F. 2003 . Use of tissel fibrin sealant in neurosurgical procedures: Incidence of cerebrospinal fluid leaks and cost-benefit analysis in a retrospective study . Neurosurgery , 52 : 1102 – 1105 .
   Google Scholar
• Kheirabadi , B. S. , Pearson , R. and Rudnicka , K. 2001 . Development of animal model for assessment of the hemostatic efficacy of fibrin sealant in vascular surgery . J. Surg. Res. , 100 : 84 – 92 .
   PubMedGoogle Scholar
• Kiilhoma , P. , Haarala , M. , Polvi , H. , Mäkinen , J. and Chancellor , M. B. 1995 . Sutureless endoscopic colposuspension with fibrin sealant . Tech. Urol. , 1 : 81 – 83 .
   Google Scholar
• Kitazawa , H. , Sato , H. , Adachi , I. , Masuko , Y. and Horikoshi , I. 1997 . Microdialysis assessment of fibrin glue containing sodium alginate for local delivery of doxorubicin in tumor-bearing rats . Biol. Pharm. Bull. , 20 : 278 – 281 .
   PubMed Web of Science ®Google Scholar
• Kjaergard , H. K. and Trumbull , H. R. 2000 . Bleeding from sternal marrow can be stopped using Vivostat patient-derived sealant . Ann. Thoracic Surg. , 69 : 1173 – 1175 .
   Google Scholar
• Koh , Y. S. , Chung , K. H. and Kim , D. S. 2001 . Biochemical characterization of thrombin-like enzyme and fibrinolytic serine protease from snake (Agkistrodon saxatilis) venom . Toxicon , 39 : 555 – 560 .
   Google Scholar
• Kram , H. B. , Ocampo , H. P. , Yamaguchi , M. P. , Nathan , R. C. and Shoemaker , W. C. 1989 . Fibrin glue in renal and ureteral trauma . Urology , 33 : 215 – 218 .
   PubMed Web of Science ®Google Scholar
• Kram , H. B. , Bansul , M. , Timberlake , O. and Sholmaker , W. C. 1991 . Antibacterial effects of fibrin glue and glue-antibiotics mixtures . J. Surg. Res. , 50 : 175 – 178 .
   PubMed Web of Science ®Google Scholar
• Lagoutte , F. M. , Gauthier , L. and Comte , P. R. M. 1989 . A fibrin sealant for perforated and preperforated corneal ulcers . Br. J. Ophthalmol. , 73 : 757 – 761 .
   PubMed Web of Science ®Google Scholar
• Lee , K. C. , Park , S. K. and Lee , K. S. 1991 . Neurosurgical application of fibrin tissue . Yon. Med. J. , 32 : 53 – 57 .
   PubMedGoogle Scholar
• Leite , C. V. S. , Naresse , L. E. , Arantes , H. L. , Lopes , A. F. , Thomazini-Santos , I. A. , Giannini , M. J. S. , Mercadante , M. C. , Barraviera , B. and Kobayasi , S. 2000 . An evaluation by rat colon anastomosis of the efficacy of fibrin glue derived from snake venom . J. Venom. Anim. Toxins , 6 : 180 – 193 .
   Google Scholar
• Lerner , R. and Binur , N. S. 1990 . Current status of surgical adhesives . J. Surg. Res. , 48 : 165 – 181 .
   Google Scholar
• Levinson , A. K. , Swanson , D. A. , Johnson , D. E. , Greskovich , F. J. , Stepheson , R. A. and Lichtiger , B. 1991 . Fibrin glue for partial nephrectomy . Urology , 38 : 314 – 316 .
   PubMed Web of Science ®Google Scholar
• Levy , O. , Martinowitz , U. , Oran , A. , Hashomer , T. and Tauber , C. 1999 . The fibrin tissue adhesive to reduce blood loss and the need for blood transfusion after total knee arthroplasty . J. Bone Joint Surg. Am. , 81 : 1580 – 1588 .
   PubMedGoogle Scholar
• Markland Junior , F. S. 1998 . Snake venoms and the hemostatic system . Toxicon , 36 : 1749 – 1800 .
   Google Scholar
• Marsh , N. A. 1994 . Snake venoms affecting the haemostatic mechanism a consideration of their mechanisms, pratical applications and biological significance . Blood Coagul. Fibrinolysis , 5 : 399 – 410 .
   PubMed Web of Science ®Google Scholar
• Marsh , N. and Williams , V. 2005 . Practical applications of snake venom toxins in haemostasis . Toxicon , 45 : 1171 – 1181 .
   PubMed Web of Science ®Google Scholar
• Martinowitz , U. , Varon , D. , Jonas , P. , Bar-Maor , A. , Brenner , B. , Leibovitch , I. and Heim , M. 1992 . Circumcision in hemophilia: The use of fibrin glue for local haemostasis . J. Urol. , 148 : 855 – 857 .
   PubMed Web of Science ®Google Scholar
• Martinowitz , U. and Spotnitz , W. D. 1997 . Fibrin tissue adhesives . Thromb. Haemost. , 78 : 661 – 666 .
   PubMed Web of Science ®Google Scholar
• Matras , H. 1985 . Fibrin seal: The state of art . J. Oral Maxillofac Surg. , 43 : 605 – 611 .
   Google Scholar
• Matras , H. , Dinges , H. P. and Monoli , B. 1972 . Zur naktlosen interfarszikularen nerventransplantation in tiex experiment . Wien. Med. Wochenschr. , 122 : 517 – 523 .
   PubMedGoogle Scholar
• Matras , H. 1982 . The use of fibrin sealant in oral and maxillofacial surgery . J. Oral Maxillofacial Surg. , 40 : 617 – 622 .
   Web of Science ®Google Scholar
• Matsui , T. , Fujimura , Y. and Titani , K. 2000 . Snake venom proteases affecting haemostasis and thrombosis . Biochim. Biophys. Acta , 1477 : 146 – 156 .
   PubMedGoogle Scholar
• McGill , V. , Kowal-Vern , A. , Lee , M. , Greenhalgh , D. G. , Gomperts , E. D. , Bray , G. and Gamelli , R. L. 1997 . Use of fibrin sealant in thermal injury . J. Burn Care Rehab. , 18 : 429 – 434 .
   Google Scholar
• Miura , S. , Mii , Y. , Miyauchi , Y. , Ohgushi , H. , Morishita , T. , Hohnoki , K. , Aoki , M. , Tama , S. and Konishi , Y. 1995 . Efficacy of slow-releasing anticancer drug delivery systems on transplantable osteosarcomas in rats . Jpn. J. Clin. Oncol. , 25 : 61 – 71 .
   PubMed Web of Science ®Google Scholar
• Moraes , J. R. E. , Correa , P. H. A. , Camplesi , A. C. and Moraes , F. R. 2004 . Experimental use of fibrin glue derived from snake venom in non-pregnant canine uterus . J. Venom. Anim. Toxins Trop. Dis. , 10 : 133 – 143 .
   Google Scholar
• Morandini , W. and Ortiz , V. 1992 . Adesivos biológicos em cirurgia . Acta Cir. Bras. , 7 : 80 – 85 .
   Google Scholar
• Mosensson , M. W. 2003 . Fibrinogen gamma chain functions . J. Thromb. Haemostasis , 1 : 231 – 238 .
   Google Scholar
• Moskovitz , M. G. , Bass , L. , Zhang , L. and Seibert , J. W. 1994 . Microvascular anastomoses utilizing new intravascular stents . Ann. Plastic Surg. , 32 : 612 – 618 .
   Google Scholar
• Nakamura , H. , Matsuyama , Y. , Yoshihara , H. , Sakai , Y. , Katayama , Y. , Nakashima , S. , Takamatsu , J. and Ishiguro , N. 2005 . The effect of autologous fibrin tissue adhesive on postoperative cerebrospinal fluid leak in spinal cord surgery; A randomized controlled trial . Spine , 30 : E347 – E351 .
   Google Scholar
• Nervi , C. , Gamelli , R. L. , Greenhalgh , D. G. , Luterman , A. , Hansbrough , J. F. , Achauer , B. M. , Gomperts , E. D. , Lee , M. , Navalta , L. and Cruciani , T.R. 2001 . A multicenter clinical trial to evaluate the topical hemostatic efficacy of fibrin sealant in burn patients . J. Burn Care Rehab. , 22 : 99 – 103 .
   Google Scholar
• Nomori , H. , Horio , H. and Svemasu , K. 2000 . Mixing collagen with fibrin glue to strengthen the sealing effect for pulmonary air leakage . Ann. Thoracic Surg. , 70 : 1666 – 1670 .
   Google Scholar
• Okereke , I. , Murthy , S. C. , Alster , J. M. , Blackstone , E. H. and Rice , T. W. 2005 . Characterization and importance of air leak after lobectomy . Ann. Thoracic Surg. , 79 : 1167 – 1173 .
   Google Scholar
• Oliveira , M. D. O. 2002 . Use of snake venom derived fibrin glue for the immobilization of free gingival grafts: clinical and histological study . J. Venom. Anim. Toxins , 8 : 325
   Google Scholar
• Oliver , D. W. , Hamilton , S. A. , Figle , A. A. , Wood , S. H. and Lamberty , B. G. 2001 . A prospective, randomized, double-blind trial of the use of fibrin sealant for face lifts . Plastic Reconstr. Surg. , 108 : 2101 – 2105 .
   Google Scholar
• Padubidri , A. N. , Browne , E. and Kononov , A. 1993 . Fibrin-glue assisted end-to-side anastomosis of rat femoral vessels: comparison with convencional suture method . Ann. Plastic Surg. , 37 : 41 – 47 .
   Google Scholar
• Pirkle , H. 1998 . Thrombin-like enzymes from snake venoms: An update inventory . Thromb. Haemost. , 79 : 675 – 683 .
   Google Scholar
• Radosevich , M. , Goubran , H. A. and Burnof , T. 1997 . Fibrin sealant: Scientific, rationale, production methods, properties and current clinical use . Vox Sang. , 72 : 133 – 143 .
   PubMed Web of Science ®Google Scholar
• Rahal , S. C. , Amaral , M. S. P. , Pai , V. D. , Barraviera , S. R. C. S. and Caporali , E. H. G. 2004 . Effect of fibrin glue derived from snake venom on the viability of autogenous split-thickness skin graft . J. Venom. Anim. Toxins Trop. Dis. , 10 : 161 – 172 .
   Google Scholar
• Rakocz , M. , Mazar , A. , Varon , D. , Spierer , S. , Blinder , D. and Martinowitz , U. 1993 . Dental extractions in patients with bleeding disorders. The use of fibrin glue . Oral Surg. Oral Med. Oral Pathol. , 75 : 280 – 282 .
   PubMedGoogle Scholar
• Rapaport , S. I. , Zivelin , A. , Minow , R. , Hunter , C. S. and Donnelly , K. 1992 . Clinical significance of antibodies to bovine and human thrombin and factor V after surgical use of bovine thrombin . Am. J. Clin. Pathol. , 97 : 84 – 91 .
   PubMed Web of Science ®Google Scholar
• Raw , I. , Rocha , M. C. , Esteves , M. I. and Kamiguti , A. S. 1986 . Isolation and characterization of a thrombin-like enzyme from the venom of Crotalus durissus terrificus . Braz. J. Med. Biol. Res. , 19 : 333 – 338 .
   PubMedGoogle Scholar
• Redl , H. , Schlag , G. , Stanek , G. , Hirschl , A. and Seelick , T. 1983 . In vitro properties of mixtures of fibrin seal and antibiotics . Biomaterials , 4 : 29 – 32 .
   PubMed Web of Science ®Google Scholar
• Reis , F. A. 2000 . A comparative study of axonal sprouting from the vagus nerve in autologous grafts . J. Venom. Anim. Toxins , 6 : 120
   Google Scholar
• Sampaio , R. L. , Ranzani , J. J. T. , Brandão , C. V. S. , Thomazini-Santos , I. A , Barraviera , B. , Barraviera , S. R. C. S. and Giannini , M. J. S. M. 2007 . Use of fibrin glue derived from snake venom in the repair of deep corneal ulcers—Experimental study in dogs . J. Venom. Anim. Toxins Trop. Dis. , 13 : 857 – 873 .
   Google Scholar
• Sartori Filho , R. , Prestes , N. C. , Thomazini , I. A. , Mendes-Giannini , M. J. S. , Toscano , E. , Canavesi , A. M. O. and Barraviera , B. 1998 . Use of fibrin glue derived from snake venom in testicular biopsy of rams . J. Venom. Anim. Toxins , 4 : 23 – 35 .
   Google Scholar
• Schwartz , M. , Madariaga , J. , Hirose , R. , Shaver , T. R. , Sher , L. , Chari , R. , Colonna , J. O. , Heaton , N. , Mirza , D. , Adams , R. , Ress , M. and Lloyd , D. 2004 . Comparison of a new fibrin sealant with standard topical hemostatic agents . Arch. Surg. , 139 : 1148 – 1154 .
   PubMed Web of Science ®Google Scholar
• Sciscione , A. C. , Manley , J. S. , Pollock , M. , Maas , M. , Shlossman , P. A. , Mulla , W. , Lankiewicz , M. and Colmorge , G. H. C. 2001 . Intracervical fibrin sealants: A potencial treatament for early preterm premature rupture of the membranes . Am. J. Obstet. Gynecol. , 184 : 368 – 373 .
   PubMed Web of Science ®Google Scholar
• Seddon , H. J. and Medawar , P. B. 1942 . Fibrin suture of human nerves . Lancet , 2 : 87 – 92 .
   Google Scholar
• Seguin , J. R. , Frapier , J. M. , Colson , P. and Chaptal , P. A. 1992 . Fibrin sealant for early repair of acquired ventricular septal defect . J. Thoracic Cardiovasc. Surg. , 104 : 748 – 751 .
   Google Scholar
• Seki , C. , Vidal , J. C. and Barrio , A. 1980 . Purification of gyroxin from a South American rattlesnake (Crotalus durissus terrificus) venom . Toxicon , 18 : 235 – 247 .
   Google Scholar
• Serrano , S. M. and Maroun , R. C. 2005 . Snake venom serine proteinases: Sequence homology vs. substrate specificity, a paradox to be solved . Toxicon , 45 : 1115 – 1132 .
   PubMed Web of Science ®Google Scholar
• Shaffrey , C. I. , Spotnitz , W. D. , Shaffrey , M. E. and Jane , J. A. 1990 . Neurosurgical applications of fibrin glue: augmentation of dural closure in 134 patients . Neurosurgery , 269 : 207 – 210 .
   Google Scholar
• Sharma , A. , Kaur , R. , Kumar , S. , Gupta , P. , Pandav , S. , Patnaik , B. and Gupta , A. 2003 . Fibrin glue versus n-butyl-2-cyanoacrylate in corneal perforation . Ophthalmology , 110 : 291 – 298 .
   PubMed Web of Science ®Google Scholar
• Sharma , S. K. , Perry , K. T. and Turk , T. M. 2005 . Endoscopic injection of fibrin glue for the treatment of urinary-tract pathology . J. Endourol. , 19 : 419 – 423 .
   PubMedGoogle Scholar
• Siedentop , K. H. , Harris , D. M. and Sanchez , B. 1989 . Autologous fibrin tissue adhesive . Laryngoscope , 95 : 1074 – 1076 .
   Google Scholar
• Sierra , D. H. 1993 . Fibrin sealant adhesive systems: A review of their chemistry, material properties ans clinical application . J. Biomater. Appl. , 7 : 309 – 352 .
   PubMedGoogle Scholar
• Spotnitz , W. D. , Mintz , P. D. , Avery , N. , Bithell , T. C. , Kauls , S. and Nolan , S. P. 1987 . Fibrin glue from stored human plasma: An inexpensive and efficient method of local blood bank preparation . Am. Surg. , 53 : 460 – 464 .
   PubMed Web of Science ®Google Scholar
• Spotnitz , W. D. and Prabhu , R. 2005 . Fibrin sealant adhesive—Review and update . J. Long-Term Effects Med. Implants , 15 : 245 – 270 .
   PubMedGoogle Scholar
• Staindl , O. 1979 . Tissue adhesion with highy concentratred human fibrinogen in otolaryngology . Ann. Otolaryngol. Rhinol. Laryngol. , 88 : 413 – 418 .
   PubMed Web of Science ®Google Scholar
• Stolf , H. O. 1999 . The use of fibrin adhesive derived from snake venom and the evaluation of skin grafting using skin from patient´s nasolabial fold . J. Venom. Anim. Toxins , 5 : 227
   Google Scholar
• Tanaka , S. , Hirohashi , K. , Tanaka , H. , Shuto , T. , Lee , S. H. , Kubo , S. , Takemura , S. , Yamamoto , T. , Uenishi , T. and Kinoshita , H. 2002 . Incidence and management of bile leakage after hepatic resection for malignant hepatic tumor . J. Am. Coll. Surg. , 195 : 484 – 489 .
   Google Scholar
• Thomazini-Santos , I. A. 2001 . Fibrin adhesive from snake venom: the effect of adding epsilon-aminocaproic acid, tranexamic acid and aprotinin for coaptation of wound in rat skin incisions . J. Venom. Anim. Toxins , 7 : 148 – 149 .
   Google Scholar
• Thomazini-Santos , I. A. , Giannini , M. J. S. M. , Toscano , E. , Machado , P. E. A. , Lima , C. R. G. and Barraviera , B. 1998 . The evaluation of clotting time in bovine thrombin, Reptilase®, and thrombin-like fraction of Crotalus durissus terrificus venom using bovine, equine, ovine, bubaline and human cryoprecipitades . J. Venom. Anim. Toxins , 4 : 120 – 136 .
   Google Scholar
• Thompson , D. F. and Davis , T. W. 1997 . The addition of antibiotics to fibrin glue . South. Med. J. , 90 : 681 – 684 .
   PubMed Web of Science ®Google Scholar
• Tidrick , R. T. and Warner , E. D. 1944 . Fibrin fixation of skin transplants . Surgery , 15 : 90 – 95 .
   Google Scholar
• Vicente , E. J. D. , Rodrigues , A. C. , Vicente , P. C. , Mármora , C. H. C. , Chagas , P. S. C. and Santos , S. M. R. 2007 . Regeneração do nervo periférico por meio de coaptação com cola de fibrina . Rev. Méd. Hosp. Univ. , 33 : 53 – 56 .
   Google Scholar
• Viterbo , F. , Thomazini , I. A. and Giannini , M. J. S. M. 1993 . Reparação de nervo periférico com cola de fibrina derivada de veneno de cobra . Acta Cir. Bras. , 8 : 85
   Google Scholar
• Wang , G. J. , Goldthwaite , C. A. and Burks , S. G. 2003 . Fibrin sealant reduces perioperative blood loss in total hip replacement . J. Long-Term Effects Med. Implants , 13 : 399 – 411 .
   PubMedGoogle Scholar
• White , J. K. , Titus , J. S. , Tanabe , H. , Aretz , T. and Torchiana , D. F. 2000 . The use of a novel tissue sealant as a hemostatic adjunct in cardiac surgery . Heart Surg. Forum , 3 : 56 – 61 .
   Google Scholar
• Wilson , S. M. , Pell , P. and Donegan , E. A. 1991 . HIV-1 transmission following the use of cryoprecipitate fibrinogen as gel/adhesive . Transfusion , 31 : 51S
   Google Scholar
• Yin , Q. , Kemp , G. J. , Yu , L. G. , Wagstaff , S. C. and Frostick , S. P. 2001 . Neurotrophin-4 delivered by fibrin glue promotes peripheral nerve regeneration . Muscle Nerve , 24 : 345 – 351 .
   PubMed Web of Science ®Google Scholar
• Young , J. Z. and Medawar , P. B. 1940 . Fibrin suture of peripheral nerves . Lancet , 2 : 126 – 128 .
   Google Scholar
• Yucel , E. A. , Oral , O. , Olgac , V. and Oral , C.K. 2003 . Effects of fibrin glue on wound heling in oral cavity . J. Dent. , 31 : 569 – 575 .
   Google Scholar