559
Views
49
CrossRef citations to date
0
Altmetric
Original Articles

Xenobiotic-Metabolizing Enzyme and Transporter Gene Expression in Primary Cultures of Human Hepatocytes Modulated by Toxcast Chemicals

, , , , , , , , , & show all
Pages 329-346 | Published online: 21 Jun 2010

REFERENCES

  • Dix , D. J. , Houck , K. A. , Martin , M. T. , Richard , A. M. , Setzer , R. W. and Kavlock , R. J. 2007 . The ToxCast program for prioritizing toxicity testing of environmental chemicals . Toxicol. Sci. , 95 : 5 – 12 .
  • Ebmeier , C. C. and Anderson , R. J. 2004 . Human thyroid phenol sulfotransferase enzymes 1A1 and 1A3: Activities in normal and diseased thyroid glands, and inhibition by thyroid hormones and phytoestrogens . J. Clin. Endocrinol. Metab. , 89 : 5597 – 5605 .
  • Food and Drug Administration. 2006. Draft guidance for industry-Drug interaction studies: Study design, data analysis, and implications for dosing and labeling. Food and Drug Administration Publication. http://www.fda.gov/downloads/Drugs/GuidanceComplianceRegulatoryInformation/Guidances/ucm072101.pdf
  • Gonzalez , F. J. and Shah , Y. M. 2008 . PPARalpha: Mechanism of species differences and hepatocarcinogenesis of peroxisome proliferators . Toxicology , 246 : 2 – 8 .
  • Guillouzo , A. , Morel , F. , Langouet , S. , Maheo , K. and Rissel , M. 1997 . Use of hepatocyte cultures for the study of hepatotoxic compounds . J. Hepatol. , 26 ( suppl. 2 ) : 73 – 80 .
  • Honkakoski , P. , Sueyoshi , T. and Negishi , M. 2003 . Drug-activated nuclear receptors CAR and PXR . Ann. Med. , 35 : 172 – 182 .
  • James , N. H. , Gill , J. H. , Brindle , R. , Woodyatt , N. J. , Macdonald , N. , Rolfe , M. , Hasmall , S. C. , Tugwood , J. D. , Holden , P. R. and Roberts , R. A. 1998 . Peroxisome proliferator-activated receptor (PPAR) alpha-regulated growth responses and their importance to hepatocarcinogenesis . Toxicol. Lett. , 102–103 : 91 – 96 .
  • Judson , R. , Richard , A. M. , Dix , D. J. , Houck , K. A. , Martin , M. T. , Kavlock , R. J. , Dellarco , V. , Henry , T. , Holderman , T. , Sayre , P. , Tan , S. , Carpenter , T. and Smith , E. 2009 . The toxicity data landscape for environmental chemicals . Environ. Health Perspect. , 117 : 685 – 695 .
  • Konno , Y. , Negishi , M. and Kodama , S. 2008 . The roles of nuclear receptors CAR and PXR in hepatic energy metabolism . Drug Metab. Pharmacokinet. , 23 : 8 – 13 .
  • LeCluyse , E. , Bullock , P. , Madan , A. , Carroll , K. and Parkinson , A. 1999 . Influence of extracellular matrix overlay and medium formulation on the induction of cytochrome P-450 2B enzymes in primary cultures of rat hepatocytes . Drug Metab. Dispos. , 27 : 909 – 915 .
  • LeCluyse , E. L. 2001 . Human hepatocyte culture systems for the in vitro evaluation of cytochrome P450 expression and regulation . Eur. J. Pharm. Sci. , 13 : 343 – 368 .
  • LeCluyse , E. L. , Alexandre , E. , Hamilton , G. A. , Viollon-Abadie , C. , Coon , D. J. , Jolley , S. and Richert , L. 2005 . Isolation and culture of primary human hepatocytes . Methods Mol. Biol. , 290 : 207 – 229 .
  • Maglich , J. M. , Watson , J , McMillen , P. J. , Goodwin , B. , Willson , T.M. and Moore , J.T. 2004 . The nuclear receptor CAR is a regulator of thyroid hormone metabolism during caloric restriction . J. Biol.Chem. , 279 : 19832 – 19838 .
  • Martin , M. T. , Judson , R. , Reif , D. M. , Kavlock , R. J. and Dix , D. J. 2009 . Profiling chemicals based on chronic toxicity results from the U.S. EPA ToxRef database . Environ. Health Perspect. , 117 : 392 – 399 .
  • Nakata , K. , Tanaka , Y. , Nakano , T. , Adachi , T. , Tanaka , H. , Kaminuma , T. and Ishikawa , T. 2006 . Nuclear receptor-mediated transcriptional regulation in Phase I, II, and III xenobiotic metabolizing systems . Drug Metab. Pharmacokinet. , 21 : 437 – 457 .
  • National Research Council . 2007 . Toxicity testing in the 21st century: A vision and a strategy , Washington, DC : National Academies Press .
  • Prueksaritanont , T. , Richards , K. M. , Qiu , Y. , Strong-Basalyga , K. , Miller , A. , Li , C. , Eisenhandler , R. and Carlini , E. J. 2005 . Comparative effects of fibrates on drug metabolizing enzymes in human hepatocytes . Pharm. Res. , 22 : 71 – 78 .
  • R Development Core Team . 2008 . R: A language and environment for statistical computing , Vienna, Austria : R Foundation for Statistical Computing .
  • Roberts , R. A. , Sabalos , C. M. , LeBlanc , M. L. , Martel , R. R. , Frutiger , Y. M. , Unger , J. M. , Botros , I. W. , Rounseville , M. P. , Seligmann , B. E. , Miller , T. P. , Grogan , T. M. and Rimsza , L. M. 2007 . Quantitative nuclease protection assay in paraffin-embedded tissue replicates prognostic microarray gene expression in diffuse large-B-cell lymphoma . Lab. Invest. , 87 : 979 – 997 .
  • Tyson , C. and Green , C. 1987 . “ Cytotoxicity measures: Choices and methods ” . In The isolated hepatocyte: Use in toxicology and xenobiotic biotransformation , 119 – 158 . New York : Academic Press .
  • Yamamoto , Y. , Moore , R. , Goldsworthy , T. L. , Negishi , M. and Maronpot , R. R. 2004 . The orphan nuclear receptor constitutive active/androstane receptor is essential for liver tumor promotion by phenobarbital in mice . Cancer Res. , 64 : 7197 – 7200 .
  • Zhang , J. H. , Chung , T. D. and Oldenburg , K. R. 1999 . A simple statistical parameter for use in evaluation and validation of high throughput screening assays . J. Biomol. Screen. , 4 : 67 – 73 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.