590
Views
74
CrossRef citations to date
0
Altmetric
Original Articles

Renal Effects of Exposure to Natural and Depleted Uranium: A Review of the Epidemiologic and Experimental Data

, , &
Pages 527-545 | Published online: 17 Dec 2010

REFERENCES

  • Abu-Qare , A. W. and Abou-Donia , M. B. 2002 . Depleted uranium—The growing concern . J. Appl. Toxicol. , 22 : 149 – 152 .
  • Arfsten , D. P. , Still , K. R. and Ritchie , G. D. 2001 . A review of the effects of uranium and depleted uranium exposure on reproduction and fetal development . Toxicol. Ind. Health , 17 : 180 – 191 .
  • Agency for Toxic Substances and Disease Registry. 1999. Toxicological profile for uranium. Atlanta, GA: U.S. Department of Health and Human Services, Agency for Toxic Substances and Disease Registry http://www.atsdr.cdc.gov/toxprofiles/tp150.pdf (http://www.atsdr.cdc.gov/toxprofiles/tp150.pdf)
  • Bagshaw , S. M. , Langenberg , C. , Haase , M. , Wan , L. , May , C. N. and Bellomo , R. 2007 . Urinary biomarkers in septic acute kidney injury . Intens. Care Med. , 33 : 1285 – 1296 .
  • Banday , A. A. , Priyamvada , S. , Farooq , N. , Yusufi , A. N. and Khan , F. 2008 . Effect of uranyl nitrate on enzymes of carbohydrate metabolism and brush border membrane in different kidney tissues . Food Chem. Toxicol. , 46 : 2080 – 2088 .
  • Birn , H. and Christensen , E. I. 2006 . Renal albumin absorption in physiology and pathology . Kidney Int. , 69 : 440 – 449 .
  • Bleise , A. , Danesi , P. R. and Burkart , W. 2003 . Properties, use and health effects of depleted uranium (DU): A general overview . J. Environ. Radioact. , 64 : 93 – 112 .
  • Boice , J. D. Jr. , Cohen , S. S. , Mumma , M. T. , Chadda , B. and Blot , W. J. 2008 . A cohort study of uranium millers and miners of Grants, New Mexico, 1979–2005 . J. Radiol. Prot. , 28 : 303 – 325 .
  • Centers for Disease Control and Prevention. 2005. Third national report on human exposure to environmental chemicals. Atlanta, GA: U.S. Centers for Disease Control and Prevention http://www.cdc.gov/exposurereport/pdf/thirdreport.pdf (http://www.cdc.gov/exposurereport/pdf/thirdreport.pdf)
  • Checkoway , H. , Pearce , N. , Crawford-Brown , D. J. and Cragle , D. L. 1988 . Radiation doses and cause-specific mortality among workers at a nuclear materials fabrication plant . Am. J. Epidemiol. , 127 : 255 – 266 .
  • Comper , W. D. , Hilliard , L. M. , Nikolic-Paterson , D. J. and Russo , L.M. 2008 . Disease-dependent mechanisms of albuminuria . Am. J. Physiol. Renal Physiol. , 295 : F1589 – F1600 .
  • Craft , E. , Abu-Qare , A. , Flaherty , M. , Garofolo , M. , Rincavage , H. and Abou-Donia , M. 2004 . Depleted and natural uranium: Chemistry and toxicological effects . J. Toxicol. Environ. Health B , 7 : 297 – 317 .
  • Domingo , J. L. , Llobet , J. M. , Tomas , J. M. and Corbella , J. 1987 . Acute toxicity of uranium in rats and mice . Bull. Environ. Contam. Toxicol. , 39 : 168 – 174 .
  • Dupree-Ellis , E. , Watkins , J. , Ingle , J. N. and Phillips , J. 2000 . External radiation exposure and mortality in a cohort of uranium processing workers . Am. J. Epidemiol. , 152 : 9195
  • Dygert , H. P. , LaBelle , C. W. , Laskin , S. , Pozzani , U. C. , Roberts , E. , Rothermel , J. J. , Rothstein , A. , Spiegl , C. J. , Sprague , G. F. and Strokinger , H. E. 1949 . “ Toxicity following inhalation ” . In Pharmacology and Toxicology of Uranium Compounds , Edited by: Voegtlin , C. and Hodge , H. C. 423 – 524 . New York : McGraw-Hill .
  • Emeigh , S. and Kinter , L. 2005 . “ Assessing renal effects of toxicants in vitro ” . In Toxicology of the kidney , 3rd , Edited by: Tarloff , J. and Lash , L. 81 – 147 . Washington, D.C : CRC Press .
  • Emeigh Hart , S. 2005 . Assessment of renal injury in vivo . J. Pharmacol. Toxicol. Methods , 52 : 30 – 45 .
  • Frome , E. L. , Cragle , D. L. and McLain , R. W. 1990 . Poisson regression analysis of the mortality among a cohort of World War II nuclear industry workers . Radiat. Res. , 123 : 138 – 152 .
  • Gilman , A. P. , Moss , M. A. , Villeneuve , D. C. , Secours , V. E. , Yagminas , A. P. , Tracy , B. L. , Quinn , J. M. , Long , G. and Valli , V. E. 1998a . Uranyl nitrate: 91-Day exposure and recovery studies in the male New Zealand white rabbit . Toxicol. Sci. , 41 : 138 – 151 .
  • Gilman , A. P. , Villeneuve , D. C. , Secours , V. E. , Yagminas , A. P. , Tracy , B. L. , Quinn , J. M. , Valli , V. E. and Moss , M. A. 1998b . Uranyl nitrate: 91-Day toxicity studies in the New Zealand white rabbit . Toxicol. Sci. , 41 : 129 – 137 .
  • Gilman , A. P. , Villeneuve , D. C. , Secours , V. E. , Yagminas , A. P. , Tracy , B. L. , Quinn , J. M. , Valli , V. E. , Willes , R. J. and Moss , M. A. 1998c . Uranyl nitrate: 28-day and 91-day toxicity studies in the Sprague-Dawley rat . Toxicol. Sci. , 41 : 117 – 128 .
  • Goel , K. A. , Garg , V. K. and Garg , V. 1980 . Histopathology of kidney of albino rat poisoned with uranyl nitrate . Bull. Environ. Contam. Toxicol. , 24 : 9 – 12 .
  • Greaves , P. 2007 . Histopathology of preclinical toxicity studies: Interpretation and relevance in drug safety evaluation , 3rd , 570 – 623 . Boston : Academic Press .
  • Guéguen , Y. , Grandcolas , L. , Baudelin , C. , Grison , S. , Tissandié , E. , Jourdain , J. R. , Paquet , F. , Voisin , P. , Aigueperse , J. , Gourmelon , P. and Souidi , M. 2007 . Effect of acetaminophen administration to rats chronically exposed to depleted uranium . Toxicology , 229 : 62 – 72 .
  • Harteloh , P. , de Bruin , K. and Kardaun , J. 2010 . The reliability of cause-of-death coding in the Netherlands . Eur. J. Epidemiol. , March 23 [Epub ahead of print]
  • Hindin , R. , Brugge , D. and Panikkar , B. 2005 . Teratogenicity of depleted uranium aerosols: A review from an epidemiological perspective . Environ. Health , 4 : 17
  • Kurttio , P. , Auvinen , A. , Salonen , L. , Saha , H. , Pekkanen , J. , Makelainen , I. , Vaisanen , S. B. , Penttila , I. M. and Komulainen , H. 2002 . Renal effects of uranium in drinking water . Environ. Health Perspect. , 110 : 337 – 342 . Erratum: Environ. Health Perspect. 111:632 (2003)
  • Kurttio , P. , Harmoinen , A. , Saha , H. , Salonen , L. , Karpas , Z. , Komulainen , H. and Auvinen , A. 2006 . Kidney toxicity of ingested uranium from drinking water . Am. J. Kidney Dis. , 47 : 972 – 982 .
  • Levey , A. S. , Stevens , L. A. , Schmid , C. H. , Zhang , Y. L. , Castro , A. F. 3rd , Feldman , H. I. , Kusek , J. W. , Eggers , P. , Van Lente , F. , Greene , T. and Coresh , J. 2009 . A new equation to estimate glomerular filtration rate . Ann. Intern. Med. , 150 : 604 – 612 .
  • Linares , V. , Belles , M. , Albina , M. L. , Sirvent , J. J. , Sanchez , D. J. and Domingo , J. L. 2006 . Assessment of the pro-oxidant activity of uranium in kidney and testis of rats . Toxicol. Lett. , 167 : 152 – 161 .
  • Loomis , D. P. and Wolf , S. H. 1996 . Mortality of workers at a nuclear materials production plant at Oak Ridge, Tennessee, 1947–1990 . Am. J. Ind. Med. , 29 : 131 – 141 .
  • Magdo , H. S. , Forman , J. , Graber , N. , Newman , B. , Klein , K. , Satlin , L. , Amler , R. W. , Winston , J. A. and Landrigan , P. J. 2007 . Grand rounds: Nephrotoxicity in a young child exposed to uranium from contaminated well water . Environ. Health Perspect. , 115 : 1237 – 1241 .
  • Mao , Y. , Desmeules , M. , Schaubel , D. , Berube , D. , Dyck , R. , Brule , D. and Thomas , B. 1995 . Inorganic components of drinking water and microalbuminuria . Environ. Res. , 71 : 135 – 140 .
  • Maynard , E. A. and Hodge , H. C. 1949 . “ Study of toxicity of various uranium compounds when fed to experiment animals ” . In Pharmacology and toxicology of uranium compounds , Edited by: Voegtlin , C. and Hodge , H. C. 309 – 376 . New York : McGraw-Hill .
  • Maynard , E. A. , Downs , W. L. and Hodge , H. C. 1953 . “ Oral toxicity of uranium compounds ” . In Pharmacology and toxicology of uranium compounds , Edited by: Voegtlin , C. and Hodge , H. C. 1221 – 1369 . New York : McGraw-Hill .
  • McDiarmid , M. A. , Squibb , K. , Engelhardt , S. , Oliver , M. , Gucer , P. , Wilson , P. D. , Kane , R. , Kabat , M. , Kaup , B. , Anderson , L. , Hoover , D. , Brown , L. D. , Jacobson-Kram , D. and Depleted Uranium Follow-Up Program . 2001 . Surveillance of depleted uranium exposed Gulf War veterans: Health effects observed in an enlarged “friendly fire” cohort . J. Occup. Environ. Med. , 43 : 991 – 1000 .
  • McDiarmid , M. A. , Engelhardt , S. , Oliver , M. , Gucer , P. , Wilson , P. D. , Kane , R. , Kabat , M. , Kaup , B. , Anderson , L. , Hoover , D. , Brown , L. , Handwerger , B. , Albertini , R. J. , Jacobson-Kram , D. , Thorne , C. D. and Squibb , K. S. 2004 . Health effects of depleted uranium on exposed Gulf War veterans: A 10-year follow-up . J. Toxicol. Environ. Health A , 67 : 277 – 296 .
  • McDiarmid , M. A. , Engelhardt , S. M. , Oliver , M. , Gucer , P. , Wilson , P. D. , Kane , R. , Kabat , M. , Kaup , B. , Anderson , L. , Hoover , D. , Brown , L. , Albertini , R. J. , Gudi , R. , Jacobson-Kram , D. , Thorne , C. D. and Squibb , K. S. 2006 . Biological monitoring and surveillance results of Gulf War I veterans exposed to depleted uranium . Int. Arch. Occup. Environ. Health , 79 : 11 – 21 .
  • McDiarmid , M. A. , Engelhardt , S. M. , Oliver , M. , Gucer , P. , Wilson , P. D. , Kane , R. , Cernich , A. , Kaup , B. , Anderson , L. , Hoover , D. , Brown , L. , Albertini , R. , Gudi , R. , Jacobson-Kram , D. and Squibb , K. S. 2007 . Health surveillance of Gulf War I veterans exposed to depleted uranium: updating the cohort . Health Phys. , 93 : 60 – 73 .
  • McDiarmid , M. A. , Engelhardt , S. M. , Dorsey , C. D. , Oliver , M. , Gucer , P. , Wilson , P. D. , Kane , R. , Cernich , A. , Kaup , B. , Anderson , L. , Hoover , D. , Brown , L. , Albertini , R. , Gudi , R. and Squibb , K. S. 2009 . Surveillance results of depleted uranium-exposed Gulf War I veterans: Sixteen years of follow-up . J Toxicol Environ Health A , 72 : 14 – 29 .
  • McDonald-Taylor , C. K. , Bhatnagar , M. K. , Gilman , A. , Yagminas , A. and Singh , A. 1992 . Uranyl nitrate-induced glomerular basement membrane alterations in rabbits: A quantitative analysis . Bull. Environ. Contam. Toxicol. , 48 : 367 – 373 .
  • McDonald-Taylor , C. K. , Singh , A. and Gilman , A. 1997 . Uranyl nitrate-induced proximal tubule alterations in rabbits: A quantitative analysis . Toxicol. Pathol. , 25 : 381 – 389 .
  • McGeoghegan , D. and Binks , K. 2000a . The mortality and cancer morbidity experience of workers at the Capenhurst uranium enrichment facility 1946–95 . J. Radiol. Prot. , 20 : 381 – 401 .
  • McGeoghegan , D. and Binks , K. 2000b . The mortality and cancer morbidity experience of workers at the Springfields uranium production facility, 1946–95 . J. Radiol. Prot. , 20 : 111 – 137 .
  • Muller , D. , Houpert , P. , Cambar , J. and Henge-Napoli , M. H. 2006 . Role of the sodium-dependent phosphate co-transporters and of the phosphate complexes of uranyl in the cytotoxicity of uranium in LLC-PK1 cells . Toxicol. Appl. Pharmacol. , 214 : 166 – 177 .
  • Muller , D. S. , Houpert , P. , Cambar , J. and Henge-Napoli , M. H. 2008 . Role of the sodium-dependent phosphate cotransporters and absorptive endocytosis in the uptake of low concentrations of uranium and its toxicity at higher concentrations in LLC-PK1 cells . Toxicol. Sci. , 101 : 254 – 262 .
  • Orloff , K. G. , Mistry , K. , Charp , P. , Metcalf , S. , Marino , R. , Shelly , T. , Melaro , E. , Donohoe , A. M. and Jones , R. L. 2004 . Human exposure to uranium in groundwater . Environ. Res. , 94 : 319 – 326 .
  • Ortega , A. , Domingo , J. L. , Llobet , J. M. , Tomas , J. M. and Paternain , J. L. 1989 . Evaluation of the oral toxicity of uranium in a 4-week drinking-water study in rats . Bull. Environ. Contam. Toxicol. , 42 : 935 – 941 .
  • Ozmen , M. and Yurekli , M. 1998 . Subacute toxicity of uranyl acetate in Swiss-albino mice . Environ. Toxicol. Pharmacol. , 6 : 111 – 115 .
  • Parkhurst , M. A. and Guilmette , R. A. 2009 . Overview of the Capstone depleted uranium study of aerosols from impact with armored vehicles: Test setup and aerosol generation, characterization, and application in assessing dose and risk . Health Phys. , 96 : 207 – 220 .
  • Pellmar , T. C. , Hogan , J. B. , Benson , K. A. and Landauer , M. R. 1998 . Toxicological evaluation of depleted uranium in rats: Six-month evaluation point , Bethesda, MD : Uniformed Services University of the Health Sciences . ADA410643
  • Pellmar , T. C. , Fuciarelli , A. F. , Ejnik , J. W. , Hamilton , M. , Hogan , J. , Strocko , S. , Emond , C. , Mottaz , H. M. and Landauer , M. R. 1999 . Distribution of uranium in rats implanted with depleted uranium pellets . Toxicol. Sci. , 49 : 29 – 39 .
  • Pinkerton , L. E. , Bloom , T. F. , Hein , M. J. and Ward , E. M. 2004 . Mortality among a cohort of uranium mill workers: An update . Occup. Environ. Med. , 61 : 57 – 64 .
  • Polednak , A. P. and Frome , E. L. 1981 . Mortality among men employed between 1943 and 1947 at a uranium-processing plant . J. Occup. Med. , 23 : 169 – 178 .
  • Prat , O. , Berenguer , F. , Malard , V. , Tavan , E. , Sage , N. , Steinmetz , G. and Quemeneur , E. 2005 . Transcriptomic and proteomic responses of human renal HEK293 cells to uranium toxicity . Proteomics , 5 : 297 – 306 .
  • Prat , O. , Vercouter , T. , Ansoborlo , E. , Fichet , P. , Perret , P. , Kurttio , P. and Salonen , L. 2009 . Uranium speciation in drinking water from drilled wells in southern Finland and its potential links to health effects . Environ. Sci. Technol. , 43 : 3941 – 3946 .
  • Renault , S. , Faiz , H. , Gadet , R. , Ferrier , B. , Martin , G. , Baverel , G. and Conjard-Duplany , A. 2010 . Uranyl nitrate inhibits lactate gluconeogenesis in isolated human and mouse renal proximal tubules: A 13C-NMR study . Toxicol. Appl. Pharmacol. , 242 : 9 – 17 .
  • Ritz , B. , Morgenstern , H. , Crawford-Brown , D. and Young , B. 2000 . The effects of internal radiation exposure on cancer mortality in nuclear workers at Rocketdyne/Atomics International . Environ. Health Perspect. , 108 : 743 – 751 .
  • Seldén , A. I. , Lundholm , C. , Edlund , B. , Hogdahl , C. , Ek , B. M. , Bergstrom , B. E. and Ohlson , C. G. 2009 . Nephrotoxicity of uranium in drinking water from private drilled wells . Environ. Res. , 109 : 486 – 494 .
  • Squibb , K. S. and McDiarmid , M. A. 2006 . Depleted uranium exposure and health effects in Gulf War veterans . Philos. Trans. R. Soc. Lond. B Biol. Sci. , 361 : 639 – 648 .
  • Taulan , M. , Paquet , F. , Maubert , C. , Delissen , O. , Demaille , J. and Romey , M. C. 2004 . Renal toxicogenomic response to chronic uranyl nitrate insult in mice . Environ. Health Perspect. , 112 : 1628 – 1635 .
  • Thiebault , C. , Carriere , M. , Milgram , S. , Simon , A. , Avoscan , L. and Gouget , B. 2007 . Uranium induces apoptosis and is genotoxic to normal rat kidney (NRK-52E) proximal cells . Toxicol. Sci. , 98 : 479 – 487 .
  • Thun , M. J. , Baker , D. B. , Steenland , K. , Smith , A. B. , Halperin , W. and Berl , T. 1985 . Renal toxicity in uranium mill workers . Scand. J. Work Environ. Health , 11 : 83 – 90 .
  • Tolkoff-Rubin , N. E. , Rubin , R. H. and Bonventre , J. V. 1988 . Noninvasive renal diagnostic studies . Clin. Lab. Med. , 8 : 507 – 526 .
  • U. S. Environmental Protection Agency . 1985 . Nationwide occurrence of radon and other natural radioactivity in public water supplies , Montgomery, AL : U. S. Environmental Protection Agency . EPA Number 520585008
  • U. S. Environmental Protection Agency. 2000. Radionuclides notice of data availability technical support document. Washington, DC: U. S. Environmental Protection Agency http://www.epa.gov/OGWDW/radionuclides/pdfs/regulation_radionuclides_rulemaking_techsupportdoc.pdf (http://www.epa.gov/OGWDW/radionuclides/pdfs/regulation_radionuclides_rulemaking_techsupportdoc.pdf)
  • Walling , M. A. 1991 . “ Morphologic manifestation of toxic cell injury ” . In Handbook of toxicologic pathology , Edited by: Haschek , W. M. , Rousseaux , C. G. and Wallig , M. A. Vol. 2 , 39 – 64 . San Diego : Academic Press .
  • Waxweiler , R. J. , Archer , V. E. and Roscoe , R. J. Mortality patterns among a retrospective cohort of uranium mill workers . Epidemiology applied to health physics, Sixteenth midyear topical meeting of the Health Physics Society . Albuquerque, NM. pp. 428 – 435 .
  • World Health Organization. 2001. Depleted uranium sources, Exposure and health effects. Geneva, Switzerland: World Health Organization http://whqlibdoc.who.int/hq/2001/WHO_SDE_PHE_01.1.pdf (http://whqlibdoc.who.int/hq/2001/WHO_SDE_PHE_01.1.pdf)
  • Zalups , R. K. , Gelein , R. M. , Morrow , P. E. and Diamond , G. L. 1988 . Nephrotoxicity of uranyl fluoride in uninephrectomized and sham-operated rats . Toxicol. Appl. Pharmacol. , 94 : 11 – 22 .
  • Zamora , M. L. L. , Zielinski , J. M. , Moodie , G. B. , Falcomer , R. A. F. , Hunt , W. C. and Capello , K. 2009 . Uranium in drinking water: Renal effects of long-term ingestion by an Aboriginal community . Arch. Environ. Occup. Health , 64 : 228 – 241 .
  • Zamora , M. L. , Tracy , B. L. , Zielinski , J. M. , Meyerhof , D. P. and Moss , M. A. 1998 . Chronic ingestion of uranium in drinking water: A study of kidney bioeffects in humans . Toxicol. Sci. , 43 : 68 – 77 .
  • Zhu , G. , Xiang , X. , Chen , X. , Wang , L. , Hu , H. and Weng , S. 2009 . Renal dysfunction induced by long-term exposure to depleted uranium in rats . Arch. Toxicol. , 83 : 37 – 46 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.