Effects of Estrogens and Endocrine-Disrupting Chemicals on Cell Differentiation–Survival–Proliferation in Brain: Contributions of Neuronal Cell Lines

REFERENCES

• Acconcia , F. , Ascenzi , P. , Bocedi , A. , Spisni , E. , Tomasi , V. , Trentalance , A. , Visca , P. and Marino , M. 2005 . Palmitoylation v-dependent estrogen receptor alpha membrane localization: Regulation by 17beta-estradiol . Mol. Biol. Cell. , 16 : 231 – 37 .
   PubMed Web of Science ®Google Scholar
• Akama , K. T. and McEwen , B. S. 2003 . Estrogen stimulates postsynaptic density-95 rapid protein synthesis via the Akt/protein kinase B pathway . J. Neurosci. , 23 : 2333 – 39 .
   PubMed Web of Science ®Google Scholar
• Alexaki , V. I. , Charalampopoulos , I. , Kampa , M. , Nifli , A.P. , Hatzoglou , A. , Gravanis , A. and Castanas , E. 2006 . Activation of membrane estrogen receptors induce pro-survival kinases . J. Steroid Biochem. Mol. Biol. , 98 : 9 – 110 .
   Web of Science ®Google Scholar
• Alexaki , V. I. , Charalampopoulos , I. , Kampa , M. , Vassalou , H. , Theodoropoulos , P. , Stathopoulos , E.N. , Hatzoglou , A. , Gravanis , A. and Castanas , E. 2004 . Estrogen exerts neuroprotective effects via membrane estrogen receptors and rapid Akt/NOS activation . FASEB J. , 18 : 1594 – 96 .
   PubMed Web of Science ®Google Scholar
• Alkayed , N. J. , Harukuni , I. , Kimes , A. S. , London , E. D. , Traystman , R. J. and Hurn , P. D. 1998 . Gender-linked brain injury in experimental stroke . Stroke , 29 : 159 – 65 . discussion 166
   PubMed Web of Science ®Google Scholar
• Alves , S. E. , McEwen , B. S. , Hayashi , S. , Korach , K. S. , Pfaff , D. W. and Ogawa , S. 2000 . Estrogen-regulated progestin receptors are found in the midbrain raphe but not hippocampus of estrogen receptor alpha ER (alpha) gene-disrupted mice . J. Comp. Neurol. , 427 : 185 – 95 .
   PubMed Web of Science ®Google Scholar
• Arditsoglou , A. and Voutsa , D. 2010 . Partitioning of endocrine disrupting compounds in inland waters and wastewaters discharged into the coastal area of Thessaloniki, Northern Greece . Environ. Sci. Pollut. Res. Int. , 17 : 529 – 38 .
   PubMed Web of Science ®Google Scholar
• Arevalo , M. A. , Santos-Galindo , M. , Bellini , M. J. , Azcoitia , I. and Garcia-Segura , L.M. 2009 . Actions of estrogens on glial cells: Implications for neuroprotection . Biochim. Biophys. Acta , 1800 : 1106 – 12 .
   PubMed Web of Science ®Google Scholar
• Arnal , J. F. , Clamens , S. , Pechet , C. , Negre-Salvayre , A. , Allera , C. , Girolami , J. P. , Salvayre , R. and Bayard , F. 1996 . Ethinylestradiol does not enhance the expression of nitric oxide synthase in bovine endothelial cells but increases the release of bioactive nitric oxide by inhibiting superoxide anion production . Proc. Natl. Acad. Sci. USA , 93 : 4108 – 13 .
   PubMed Web of Science ®Google Scholar
• Baker , A. E. , Brautigam , V. M. and Watters , J. J. 2004 . Estrogen modulates microglial inflammatory mediator production via interactions with estrogen receptor beta . Endocrinology , 145 : 5021 – 32 .
   PubMed Web of Science ®Google Scholar
• Barrek , S. , Cren-Olive , C. , Wiest , L. , Baudot , R. , Arnaudguilhem , C. and Grenier-Loustalot , M. F. 2009 . Multi-residue analysis and ultra-trace quantification of 36 priority substances from the European Water Framework Directive by GC-MS and LC-FLD-MS/MS in surface waters . Talant , 79 : 712 – 22 .
   PubMed Web of Science ®Google Scholar
• Behl , C. 2002 . Oestrogen as a neuroprotective hormone . Nat. Rev. Neurosci. , 3 : 433 – 42 .
   PubMed Web of Science ®Google Scholar
• Billon-Gales , A. , Fontaine , C. , Filipe , C. , Douin-Echinard , V. , Fouque , M. J. , Flouriot , G. , Gourdy , P. , Lenfant , F. , Laurell , H. , Krust , A. , Chambon , P. and Arnal , J. F. 2009 . The transactivating function 1 of estrogen receptor alpha is dispensable for the vasculoprotective actions of 17beta-estradiol . Proc. Natl. Acad. Sci. USA , 106 : 2053 – 58 .
   PubMed Web of Science ®Google Scholar
• Bjornstrom , L. and Sjoberg , M. 2002 . Signal transducers and activators of transcription as downstream targets of nongenomic estrogen receptor actions . Mol. Endocrinol. , 16 : 2202 – 14 .
   PubMedGoogle Scholar
• Blaustein , J. D. 2010 . The year in neuroendocrinology . Mol. Endocrinol. , 24 : 252 – 60 .
   PubMedGoogle Scholar
• Bonnefont , A. B. , Munoz , F. J. and Inestrosa , N. C. 1998 . Estrogen protects neuronal cells from the cytotoxicity induced by acetylcholinesterase-amyloid complexes . FEBS Lett. , 441 : 220 – 24 .
   PubMed Web of Science ®Google Scholar
• Bouron , A. , Becker , C. and Porzig , H. 1999 . Functional expression of voltage-gated Na+ and Ca2+ channels during neuronal differentiation of PC12 cells with nerve growth factor or forskolin . Naunyn Schmiedebergs Arch. Pharmacol. , 359 : 370 – 77 .
   PubMed Web of Science ®Google Scholar
• Brailoiu , E. , Dun , S. L. , Brailoiu , G. C. , Mizuo , K. , Sklar , L. A. , Oprea , T. I. , Prossnitz , E. R. and Dun , N. J. 2007 . Distribution and characterization of estrogen receptor G protein-coupled receptor 30 in the rat central nervous system . J. Endocrinol , 193 : 311 – 21 .
   PubMed Web of Science ®Google Scholar
• Bredhult , C. , Backlin , B. M. and Olovsson , M. 2007 . Effects of some endocrine disruptors on the proliferation and viability of human endometrial endothelial cells in vitro . Reprod. Toxicol. , 23 : 550 – 59 .
   PubMed Web of Science ®Google Scholar
• Brown , J. S. Jr. 2009 . Effects of bisphenol-A and other endocrine disruptors compared with abnormalities of schizophrenia: An endocrine-disruption theory of schizophrenia . Schizophr. Bull. , 35 : 256 – 78 .
   PubMed Web of Science ®Google Scholar
• Bruce-Keller , A. J. , Keeling , J. L. , Keller , J. N. , Huang , F. F. , Camondola , S. and Mattson , M. P. 2000 . Antiinflammatory effects of estrogen on microglial activation . Endocrinology , 141 : 3646 – 56 .
   PubMed Web of Science ®Google Scholar
• Chen , T. C. , Shue , M. F. , Yeh , Y. L. , Hsieh , C. Y. , Kuo , Y. T. and Kuo , C. T. 2009 . Variation, correlation, and toxicity of phenolic endocrine-disrupting compounds in surface water . J. Environ. Sci. Health A Toxicol. Hazard Subst. Environ. Eng. , 44 : 1244 – 50 .
   PubMed Web of Science ®Google Scholar
• Chiasson , K. , Lahaie-Collins , V. , Bournival , J. , Delapierre , B. , Gelinas , S. and Martinoli , M. G. 2006 . Oxidative stress and 17-alpha- and 17-beta-estradiol modulate neurofilaments differently . J. Mol. Neurosci. , 30 : 297 – 10 .
   PubMed Web of Science ®Google Scholar
• Choi , S. M. , Yoo , S. D. and Lee , B. M. 2004 . Toxicological characteristics of endocrine-disrupting chemicals: Developmental, carcinogenicity and mutagenicity . J. Toxicol. Environ. Health B , 7 : 1 – 24 .
   PubMed Web of Science ®Google Scholar
• Ciana , P. , Ghisletti , S. , Mussi , P. , Eberini , I. , Vegeto , E. and Maggi , A. 2003 . Estrogen receptor alpha, a molecular switch converting transforming growth factor-alpha-mediated proliferation into differentiation in neuroblastoma cells . J. Biol. Chem. , 278 : 31737 – 44 .
   PubMed Web of Science ®Google Scholar
• Colborn , T. , vom Saal , F. S. and Soto , A. M. 1993 . Developmental effects of endocrine-disrupting chemicals in wildlife and humans . Environ. Health Perspect , 101 : 378 – 84 .
   PubMed Web of Science ®Google Scholar
• Denier , X. , Couteau , J. , Baudrimont , M. , Hill , E. M. , Rotchell , J. and Minier , C. 2008 . In vitro study of the effects of cadmium on the activation of the estrogen response element using the YES screen . Mar. Environ. Res. , 66 : 108 – 10 .
   PubMed Web of Science ®Google Scholar
• DeRosa , C. , Richter , P. , Pohl , H. and Jones , D. E. 1998 . Environmental exposures that affect the endocrine system: Public health implications . J. Toxicol. Environ. Health B , 1 : 3 – 26 .
   PubMed Web of Science ®Google Scholar
• Dhooge , W. , Arijs , K. , D'Haese , I. , Stuyvaert , S. , Versonnen , B. , Janssen , C. , Verstraete , W. and Comhaire , F. 2006 . Experimental parameters affecting sensitivity and specificity of a yeast assay for estrogenic compounds: Results of an interlaboratory validation exercise . Anal. Bioanal. Chem. , 386 : 1419 – 28 .
   PubMed Web of Science ®Google Scholar
• Dodel , R. C. , Du , Y. , Bales , K. R. , Gao , F. and Paul , S. M. 1999 . Sodium salicylate and 17beta-estradiol attenuate nuclear transcription factor NF-kappaB translocation in cultured rat astroglial cultures following exposure to amyloid A beta(1–40) and lipopolysaccharides . J. Neurochem. , 73 : 1453 – 60 .
   PubMed Web of Science ®Google Scholar
• Du , B. , Ohmichi , M. , Takahashi , K. , Kawagoe , J. , Ohshima , C. , Igarashi , H. , Mori-Abe , A. , Saitoh , M. , Ohta , T. , Ohishi , A. , Doshida , M. , Tezuka , N. , Takahashi , T. and Kurachi , H. 2004 . Both estrogen and raloxifene protect against beta-amyloid-induced neurotoxicity in estrogen receptor alpha-transfected PC12 cells by activation of telomerase activity via Akt cascade . J. Endocrinol. , 183 : 605 – 15 .
   PubMed Web of Science ®Google Scholar
• Dubal , D. B. , Kashon , M. L. , Pettigrew , L. C. , Ren , J. M. , Finklestein , S. P. , Rau , S. W. and Wise , P. M. 1998 . Estradiol protects against ischemic injury . J. Cereb. Blood Flow Metab. , 18 : 1253 – 58 .
   PubMed Web of Science ®Google Scholar
• Dubal , D. B. , Rau , S. W. , Shughrue , P. J. , Zhu , H. , Yu , J. , Cashion , A. B. , Suzuki , S. , Gerhold , L. M. , Bottner , M. B. , Dubal , S. B. , Merchanthaler , I. , Kindy , M. S. and Wise , P. M. 2006 . Differential modulation of estrogen receptors (ERs) in ischemic brain injury: A role for ERalpha in estradiol-mediated protection against delayed cell death . Endocrinology , 147 : 3076 – 84 .
   PubMed Web of Science ®Google Scholar
• Dubal , D. B. , Shughrue , P. J. , Wilson , M. E. , Merchenthaler , I. and Wise , P. M. 1999 . Estradiol modulates bcl-2 in cerebral ischemia: A potential role for estrogen receptors . J. Neurosci , 19 : 6385 – 93 .
   PubMed Web of Science ®Google Scholar
• Dubal , D. B. , Zhu , H. , Yu , J. , Rau , S. W. , Shughrue , P. J. , Merchenthaler , I. , Kindy , M. S. and Wise , P. M. 2001 . Estrogen receptor alpha, not beta, is a critical link in estradiol-mediated protection against brain injury . Proc. Natl. Acad. Sci. USA , 98 : 1952 – 57 .
   PubMed Web of Science ®Google Scholar
• Duong , C. N. , Ra , J. S. , Cho , J. , Kim , S.D. , Choi , H. K. , Park , J. H. , Kim , K. W. , Inam , E. and Kim , S. D. 2010 . Estrogenic chemicals and estrogenicity in river waters of South Korea and seven Asian countries . Chemosphere , 78 : 286 – 93 .
   Google Scholar
• Edwards , D. P. 2005 . Regulation of signal transduction pathways by estrogen and progesterone . Annu. Rev. Physiol. , 67 : 335 – 76 .
   PubMed Web of Science ®Google Scholar
• Elzer , J. G. , Muhammad , S. , Wintermantel , T. M. , Regnier-Vigouroux , A. , Ludwig , J. , Schutz , G. and Schwaninger , M. 2010 . Neuronal estrogen receptor-alpha mediates neuroprotection by 17beta-estradiol . J. Cereb. Blood Flow Metab. , 30 : 935 – 42 .
   PubMed Web of Science ®Google Scholar
• Flouriot , G. , Brand , H. , Denger , S. , Metivier , R. , Kos , M. , Reid , G. , Sonntag-Buck , V. and Gannon , F. 2000 . Identification of a new isoform of the human estrogen receptor-alpha (hER-alpha) that is encoded by distinct transcripts and that is able to repress hER-alpha activation function 1 . EMBO J. , 19 : 4688 – 700 .
   PubMed Web of Science ®Google Scholar
• Flouriot , G. , Pakdel , F. , Ducouret , B. and Valotaire , Y. 1995 . Influence of xenobiotics on rainbow trout liver estrogen receptor and vitellogenin gene expression . J. Mol. Endocrinol. , 15 : 143 – 51 .
   PubMed Web of Science ®Google Scholar
• Froissard , P. , Monrocq , H. and Duval , D. 1997 . Role of glutathione metabolism in the glutamate-induced programmed cell death of neuronal-like PC12 cells . Eur. J. Pharmacol. , 326 : 93 – 99 .
   PubMed Web of Science ®Google Scholar
• Fukui , M. , Choi , H. J. and Zhu , B. T. 2010 . Mechanism for the protective effect of resveratrol against oxidative stress-induced neuronal death in HT22 cells . Free Radical Biol. Med. , [Epub ahead of print]
   Web of Science ®Google Scholar
• Gagne , B. , Gelinas , S. , Bureau , G. , Lagace , B. , Ramassamy , C. , Chiasson , K. , Valastro , B. and Martinoli , M. G. 2003 . Effects of estradiol, phytoestrogens, and Ginkgo biloba extracts against 1-methyl-4-phenyl-pyridine-induced oxidative stress . Endocrine , 21 : 89 – 95 .
   PubMed Web of Science ®Google Scholar
• Garcia-Segura , L. M. , Duenas , M. , Fernandez-Galaz , M. C. , Chowen , J. A. , Argente , J. , Naftolin , F. and Torres-Aleman , I. 1996 . Interaction of the signalling pathways of insulin-like growth factor-I and sex steroids in the neuroendocrine hypothalamus . Hormone Res. , 46 : 160 – 64 .
   PubMedGoogle Scholar
• Garmy-Susini , B. , Delmas , E. , Gourdy , P. , Zhou , M. , Bossard , C. , Bugler , B. , Bayard , F. , Krust , A. , Prats , A. C. , Doetschman , T. , Prats , H. and Arnal , J. F. 2004 . Role of fibroblast growth factor-2 isoforms in the effect of estradiol on endothelial cell migration and proliferation . Circ. Res. , 94 : 1301 – 9 .
   PubMed Web of Science ®Google Scholar
• Garnier , M. , Di Lorenzo , D. , Albertini , A. and Maggi , A. 1997 . Identification of estrogen-responsive genes in neuroblastoma SK-ER3 cells . J. Neurosci. , 17 : 4591 – 99 .
   PubMed Web of Science ®Google Scholar
• George , J. , Banik , N. L. and Ray , S. K. 2010 . Genistein induces receptor and mitochondrial pathways and increases apoptosis during BCL-2 knockdown in human malignant neuroblastoma SK-N-DZ cells . J. Neurosci. Res. , 88 : 877 – 86 .
   PubMed Web of Science ®Google Scholar
• Gollapudi , L. and Oblinger , M. M. 1999a . Estrogen and NGF synergistically protect terminally differentiated, ERalpha-transfected PC12 cells from apoptosis . J. Neurosci. Res. , 56 : 471 – 81 .
   PubMed Web of Science ®Google Scholar
• Gollapudi , L. and Oblinger , M. M. 1999b . Stable transfection of PC12 cells with estrogen receptor (ERalpha): Protective effects of estrogen on cell survival after serum deprivation . J. Neurosci. Res. , 56 : 99 – 108 .
   PubMed Web of Science ®Google Scholar
• Gollapudi , L. and Oblinger , M. M. 2001 . Estrogen effects on neurite outgrowth and cytoskeletal gene expression in ERalpha-transfected PC12 cell lines . Exp. Neurol. , 171 : 308 – 16 .
   PubMed Web of Science ®Google Scholar
• Gonzalez , M. , Cabrera-Socorro , A. , Perez-Garcia , C. G. , Fraser , J. D. , Lopez , F. J. , Alonso , R. and Meyer , G. 2007 . Distribution patterns of estrogen receptor alpha and beta in the human cortex and hippocampus during development and adulthood . J. Comp. Neurol. , 503 : 790 – 802 .
   PubMed Web of Science ®Google Scholar
• Gore , A. C. 2008 . Developmental programming and endocrine disruptor effects on reproductive neuroendocrine systems . Front. Neuroendocrinol. , 29 : 358 – 74 .
   PubMed Web of Science ®Google Scholar
• Green , P. S. , Gridley , K. E. and Simpkins , J. W. 1998 . Nuclear estrogen receptor-independent neuroprotection by estratrienes: A novel interaction with glutathione . Neuroscience , 84 : 7 – 10 .
   PubMed Web of Science ®Google Scholar
• Greene , L. A. and Tischler , A. S. 1976 . Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor . Proc. Natl. Acad. Sci. USA , 73 : 2424 – 28 .
   PubMed Web of Science ®Google Scholar
• Gu , Q. , Korach , K. S. and Moss , R. L. 1999 . Rapid action of 17beta-estradiol on kainate-induced currents in hippocampal neurons lacking intracellular estrogen receptors . Endocrinology , 140 : 660 – 66 .
   PubMed Web of Science ®Google Scholar
• Guillette , L. J. Jr. , Gross , T. S. , Masson , G. R. , Matter , J. M. , Percival , H. F. and Woodward , A. R. 1994 . Developmental abnormalities of the gonad and abnormal sex hormone concentrations in juvenile alligators from contaminated and control lakes in Florida . Environ. Health Perspect , 102 : 680 – 88 .
   PubMed Web of Science ®Google Scholar
• Guillette , L. J. Jr , Pickford , D. B. , Crain , D. A. , Rooney , A. A. and Percival , H. F. 1996 . Reduction in penis size and plasma testosterone concentrations in juvenile alligators living in a contaminated environment . Gen. Comp. Endocrinol. , 101 : 32 – 42 .
   PubMed Web of Science ®Google Scholar
• Guo , J. , Krause , D. N. , Horne , J. , Weiss , J. H. , Li , X. and Duckles , S. P. 2010 . Estrogen-receptor-mediated protection of cerebral endothelial cell viability and mitochondrial function after ischemic insult in vitro . J. Cereb. Blood Flow Metab. , 30 : 545 – 54 .
   PubMed Web of Science ®Google Scholar
• Gursoy , E. , Cardounel , A. , Al-khlaiwi , T. , Al-drees , A. and Kalimi , M. 2002 . Tamoxifen protects clonal mouse hippocampal (HT-22) cells against neurotoxins-induced cell death . Neurochem. Int. , 40 : 405 – 12 .
   PubMed Web of Science ®Google Scholar
• Gursoy , E. , Cardounel , A. and Kalimi , M. 2001 . The environmental estrogenic compound bisphenol A exerts estrogenic effects on mouse hippocampal (HT-22) cells: Neuroprotection against glutamate and amyloid beta protein toxicity . Neurochem. Int. , 38 : 181 – 86 .
   PubMed Web of Science ®Google Scholar
• Habauzit , D. , Armengaud , J. , Roig , B. and Chopineau , J. 2008 . Determination of estrogen presence in water by SPR using estrogen receptor dimerization . Anal. Bioanal. Chem. , 390 : 873 – 83 .
   PubMed Web of Science ®Google Scholar
• Habauzit , D. , Boudot , A. , Kerdivel , G. , Flouriot , G. and Pakdel , F. 2010 . Development and validation of a test for environmental estrogens: Checking xeno-estrogen activity by CXCL12 secretion in breast cancer cell lines (CXCL-test) . Environ. Toxicol , 25 : 495 – 503 .
   PubMed Web of Science ®Google Scholar
• Habauzit , D. , Chopineau , J. and Roig , B. 2007 . SPR-based biosensors: A tool for biodetection of hormonal compounds . Anal. Bioanal. Chem. , 387 : 1215 – 23 .
   PubMed Web of Science ®Google Scholar
• Hall , E. D. , Pazara , K. E. and Linseman , K. L. 1991 . Sex differences in postischemic neuronal necrosis in gerbils . J. Cereb. Blood Flow Metab. , 11 : 292 – 98 .
   PubMed Web of Science ®Google Scholar
• Harrington , W. R. , Kim , S. H. , Funk , C. C. , Madak-Erdogan , Z. , Schiff , R. , Katzenellenbogen , J. A. and Katzenellenbogen , B. S. 2006 . Estrogen dendrimer conjugates that preferentially activate extranuclear, nongenomic versus genomic pathways of estrogen action . Mol. Endocrinol. , 20 : 491 – 502 .
   PubMed Web of Science ®Google Scholar
• Harris-White , M. E. , Chu , T. , Miller , S. A. , Simmons , M. , Teter , B. , Nash , D. , Cole , G. M. and Frautschy , S. A. 2001 . Estrogen (E2) and glucocorticoid (Gc) effects on microglia and A beta clearance in vitro and in vivo . Neurochem. Int. , 39 : 435 – 48 .
   PubMed Web of Science ®Google Scholar
• Henderson , B. E. , Ross , R. and Bernstein , L. 1988 . Estrogens as a cause of human cancer: The Richard and Hinda Rosenthal Foundation award lecture . Cancer Res. , 48 : 246 – 53 .
   PubMed Web of Science ®Google Scholar
• Higuchi , Y. and Matsukawa , S. 1999 . Glutathione depletion induces giant DNA and high-molecular-weight DNA fragmentation associated with apoptosis through lipid peroxidation and protein kinase C activation in C6 glioma cells . Arch. Biochem. Biophys. , 363 : 33 – 42 .
   PubMed Web of Science ®Google Scholar
• Hojo , Y. , Murakami , G. , Mukai , H. , Higo , S. , Hatanaka , Y. , Ogiue-Ikeda , M. , Ishii , H. , Kimoto , T. and Kawato , S. 2008 . Estrogen synthesis in the brain–role in synaptic plasticity and memory . Mol. Cell. Endocrinol. , 290 : 31 – 43 .
   PubMed Web of Science ®Google Scholar
• Jonkers , N. , Sousa , A. , Galante-Oliveira , S. , Barroso , C. M. , Kohler , H. P. and Giger , W. 2010 . Occurrence and sources of selected phenolic endocrine disruptors in Ria de Aveiro, Portugal . Environ. Sci. Pollut. Res. Int. , 17 : 834 – 43 .
   PubMed Web of Science ®Google Scholar
• Jung , J. Y. , Roh , K. H. , Jeong , Y. J. , Kim , S. H. , Lee , E. J. , Kim , M. S. , Oh , W. M. , Oh , H. K. and Kim , W. J. 2008 . Estradiol protects PC12 cells against CoCl2-induced apoptosis . Brain Res. Bull. , 76 : 579 – 85 .
   PubMed Web of Science ®Google Scholar
• Kajta , M. , Lason , W. and Kupiec , T. 2004 . Effects of estrone on N-methyl-D-aspartic acid- and staurosporine-induced changes in caspase-3-like protease activity and lactate dehydrogenase-release: Time- and tissue-dependent effects in neuronal primary cultures . Neuroscience , 123 : 515 – 26 .
   PubMed Web of Science ®Google Scholar
• Kang , M. K. , Kang , N. J. , Jang , Y. J. , Lee , K. W. and Lee , H. J. 2009 . Gallic acid induces neuronal cell death through activation of c-Jun N-terminal kinase and downregulation of Bcl-2 . Ann. NY Aca Sci , 1171 : 514 – 20 .
   PubMed Web of Science ®Google Scholar
• Kavlock , R. J. , Daston , G. P. , DeRosa , C. , Fenner-Crisp , P. , Gray , L. E. , Kaattari , S. , Lucier , G. , Luster , M. , Mac , M. J. , Maczka , C. , Miller , R. , Moore , J. , Rolland , R. , Scott , G. , Sheehan , D. M. , Sinks , T. and Tilson , H. A. 1996 . Research needs for the risk assessment of health and environment . Environ. Health Perspect , 104 ( suppl. 4 ) : 715 – 40 .
   PubMed Web of Science ®Google Scholar
• Kim , K. , Thu , N. , Saville , B. and Safe , S. 2003 . Domains of estrogen receptor alpha (ERalpha) required for ERalpha/Sp1-mediated activation of GC-rich promoters by estrogens and antiestrogens in breast cancer cells . Mol. Endocrinol. , 17 : 804 – 17 .
   PubMedGoogle Scholar
• Kim , K. , Son , T.G. , Kim , S.J. , Kim , H. S. , Kim , T. S. , Han , S. Y. and Lee , J. 2007 . Suppressive effects of bisphenol A on the proliferation of neural progenitor cells . J. Toxicol. Environ. Health A , 70 : 1288 – 95 .
   PubMed Web of Science ®Google Scholar
• Kimura-Kuroda , J. , Nagata , I. and Kuroda , Y. 2007 . Disrupting effects of hydroxy-polychlorinated biphenyl (PCB) congeners on neuronal development of cerebellar Purkinje cells: A possible causal factor for developmental brain disorders? . Chemosphere , 67 : S412 – 420 .
   Web of Science ®Google Scholar
• Kipp , M. , Karakaya , S. , Johann , S. , Kampmann , E. , Mey , J. and Beyer , C. 2007 . Oestrogen and progesterone reduce lipopolysaccharide-induced expression of tumour necrosis factor-alpha and interleukin-18 in midbrain astrocytes . J. Neuroendocrinol. , 19 : 819 – 22 .
   PubMed Web of Science ®Google Scholar
• Klintsova , A. , Levy , W. B. and Desmond , N. L. 1995 . Astrocytic volume fluctuates in the hippocampal CA1 region across the estrous cycle . Brain Res. , 690 : 269 – 74 .
   PubMed Web of Science ®Google Scholar
• Klotz , D. M. , Beckman , B. S. , Hill , S. M. , McLachlan , J. A. , Walters , M. R. and Arnold , S. F. 1996 . Identification of environmental chemicals with estrogenic activity using a combination of in vitro assays . Environ. Health Perspect , 104 : 1084 – 89 .
   PubMed Web of Science ®Google Scholar
• Koh , P. O. , Won , C. K. and Cho , J. H. 2006 . Estradiol prevents the injury-induced decrease of Akt/glycogen synthase kinase 3beta phosphorylation . Neurosci Lett , 404 : 303 – 8 .
   PubMed Web of Science ®Google Scholar
• Kos , M. , Denger , S. , Reid , G. , Korach , K. S. and Gannon , F. 2002 . Down but not out? A novel protein isoform of the estrogen receptor alpha is expressed in the estrogen receptor alpha knockout mouse . J. Mol. Endocrinol. , 29 : 281 – 86 .
   PubMed Web of Science ®Google Scholar
• Krause , D. N. , Duckles , S. P. and Pelligrino , D. A. 2006 . Influence of sex steroid hormones on cerebrovascular function . J. Appl. Physiol. , 101 : 1252 – 61 .
   PubMed Web of Science ®Google Scholar
• Kudo , C. , Wada , K. , Masuda , T. , Yonemura , T. , Shibuya , A. , Fujimoto , Y. , Nakajima , A. , Niwa , H. and Kamisaki , Y. 2004 . Nonylphenol induces the death of neural stem cells due to activation of the caspase cascade and regulation of the cell cycle . J. Neurochem. , 88 : 1416 – 23 .
   PubMed Web of Science ®Google Scholar
• Kuiper , G. G. , Carlsson , B. , Grandien , K. , Enmark , E. , Haggblad , J. , Nilsson , S. and Gustafsson , J. A. 1997 . Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta . Endocrinology , 138 : 863 – 70 .
   PubMed Web of Science ®Google Scholar
• Kushner , P. J. , Agard , D. A. , Greene , G. L. , Scanlan , T. S. , Shiau , A. K. , Uht , R. M. and Webb , P. 2000 . Estrogen receptor pathways to AP-1 . J. Steroid Biochem. Mol. Biol. , 74 : 311 – 17 .
   PubMed Web of Science ®Google Scholar
• Kusunoki , T. , Shimoke , K. , Komatsubara , S. , Kishi , S. and Ikeuchi , T. 2008 . p-Nonylphenol induces endoplasmic reticulum stress-mediated apoptosis in neuronally differentiated PC12 cells . Neurosci. Lett. , 431 : 256 – 61 .
   PubMed Web of Science ®Google Scholar
• Langer , G. , Bader , B. , Meoli , L. , Isensee , J. , Delbeck , M. , Noppinger , P. R. and Otto , C. 2010 . A critical review of fundamental controversies in the field of GPR30 research . Steroids , 75 : 603 – 10 .
   PubMed Web of Science ®Google Scholar
• Le Foll , I. and Duval , D. P. 2001 . Programmed cell death induced by glutathione depletion in PC 12 cells is blocked by inhibitors of 12 lipoxygenase, but does not appear to be mediated through the formation of 12 HETE derivatives . Free Radical Biol. Med. , 30 : 793 – 802 .
   PubMed Web of Science ®Google Scholar
• Le Guevel , R. and Pakdel , F. 2001 . Assessment of oestrogenic potency of chemicals used as growth promoter by in-vitro methods . Hum. Reprod. , 16 : 1030 – 36 .
   PubMed Web of Science ®Google Scholar
• Le Guevel , R. , Petit , F.G. , Le Goff , P. , Metivier , R. , Valotaire , Y. and Pakdel , F. 2000 . Inhibition of rainbow trout (Oncorhynchus mykiss) estrogen receptor activity by cadmium . Biol. Reprod. , 63 : 259 – 66 .
   PubMed Web of Science ®Google Scholar
• Lebesgue , D. , Chevaleyre , V. , Zukin , R. S. and Etgen , A. M. 2009 . Estradiol rescues neurons from global ischemia-induced cell death: multiple cellular pathways of neuroprotection . Steroids , 74 : 555 – 61 .
   PubMed Web of Science ®Google Scholar
• Lee , Y. M. , Seong , M. J. , Lee , J. W. , Lee , Y. K. , Kim , T. M. , Nam , S. Y. , Kim , D. J. , Yun , Y. W. , Kim , T. S. , Han , S. Y. and Hong , J. T. 2007 . Estrogen receptor independent neurotoxic mechanism of bisphenol A, an environmental estrogen . J. Vet. Sci. , 8 : 27 – 38 .
   PubMed Web of Science ®Google Scholar
• Leranth , C. , Hajszan , T. , Szigeti-Buck , K. , Bober , J. and MacLusky , N. J. 2008 . Bisphenol A prevents the synaptogenic response to estradiol in hippocampus and prefrontal cortex of ovariectomized nonhuman primates . Proc. Natl. Acad. Sci. USA , 105 : 14187 – 91 .
   PubMed Web of Science ®Google Scholar
• Levin , E. R. 2005 . Integration of the extranuclear and nuclear actions of estrogen . Mol. Endocrinol. , 19 : 1951 – 59 .
   PubMed Web of Science ®Google Scholar
• Levin , E. R. 2009 . G protein-coupled receptor 30: Estrogen receptor or collaborator? . Endocrinology , 150 : 1563 – 65 .
   PubMed Web of Science ®Google Scholar
• Li , W. , Seifert , M. , Xu , Y. and Hock , B. 2004 . Comparative study of estrogenic potencies of estradiol, tamoxifen, bisphenol-A and resveratrol with two in vitro bioassays . Environ. Int. , 30 : 329 – 35 .
   PubMed Web of Science ®Google Scholar
• Losordo , D. W. and Isner , J. M. 2001 . Estrogen and angiogenesis: A review . Arterioscler. Thromb. Vasc. Biol. , 21 : 6 – 12 .
   PubMed Web of Science ®Google Scholar
• Lu , C. B. , Fu , W. , Xu , X. and Mattson , M. P. 2009 . Numb-mediated neurite outgrowth is isoform-dependent, and requires activation of voltage-dependent calcium channels . Neuroscience , 161 : 403 – 12 .
   PubMed Web of Science ®Google Scholar
• Ma , T. C. , Campana , A. , Lange , P.S. , Lee , H. H. , Banerjee , K. , Bryson , J.B. , Mahishi , L. , Alam , S. , Giger , R. J. , Barnes , S. , Morris , S. M. Jr. , Willis , D. E. , Twiss , J. L. , Filbin , M. T. and Ratan , R. R. 2010a . A large-scale chemical screen for regulators of the arginase 1 promoter identifies the soy isoflavone daidzeinas a clinically approved small molecule that can promote neuronal protection or regeneration via a cAMP-independent pathway . J. Neurosci. , 30 : 739 – 48 .
   PubMed Web of Science ®Google Scholar
• Ma , W. , Yuan , L. , Yu , H. , Ding , B. , Xi , Y. , Feng , J. and Xiao , R. 2010b . Genistein as a neuroprotective antioxidant attenuates redox imbalance induced by beta-amyloid peptides 25–35 in PC12 cells . Int. J. Dev. Neurosci. , 28 : 289 – 95 .
   PubMed Web of Science ®Google Scholar
• Maggi , A. , Ciana , P. , Belcredito , S. and Vegeto , E. 2004 . Estrogens in the nervous system: mechanisms and nonreproductive functions . Annu. Rev. Physiol. , 66 : 291 – 313 .
   PubMed Web of Science ®Google Scholar
• Masuo , Y. , Ishido , M. , Morita , M. and Oka , S. 2004 . Effects of neonatal treatment with 6-hydroxydopamine and endocrine disruptors on motor activity and gene expression in rats . Neural Plast , 11 : 59 – 76 .
   PubMedGoogle Scholar
• Matsunaga , H. , Mizota , K. , Uchida , H. , Uchida , T. and Ueda , H. 2010 . Endocrine disrupting chemicals bind to a novel receptor, microtubule-associated protein 2, and positively and negatively regulate dendritic outgrowth in hippocampal neurons . J. Neurochem. , [Epub ahead of print]
   PubMed Web of Science ®Google Scholar
• McCarthy , M. M. 2008 . Estradiol and the developing brain . Physiol. Rev. , 88 : 91 – 124 .
   PubMed Web of Science ®Google Scholar
• McCullough , L. D. and Hurn , P. D. 2003 . Estrogen and ischemic neuroprotection: an integrated view . Trends Endocrinol. Metab. , 14 : 228 – 35 .
   PubMed Web of Science ®Google Scholar
• McEwen , B. 2002 . Estrogen actions throughout the brain . Recent Prog. Hormone Res. , 57 : 357 – 84 .
   PubMedGoogle Scholar
• McEwen , B. , Akama , K. , Alves , S. , Brake , W. G. , Bulloch , K. , Lee , S. , Li , C. , Yuen , G. and Milner , T. A. 2001 . Tracking the estrogen receptor in neurons: Implications for estrogen-induced synapse formation . Proc. Natl. Acad. Sci. USA , 98 : 7093 – 100 .
   PubMed Web of Science ®Google Scholar
• Mendelsohn , M. E. 2000 . Nongenomic, ER-mediated activation of endothelial nitric oxide synthase: How does it work? What does it mean? . Circ Res , 87 : 956 – 60 .
   PubMed Web of Science ®Google Scholar
• Merot , Y. , Ferriere , F. , Debroas , E. , Flouriot , G. , Duval , D. and Saligaut , C. 2005 . Estrogen receptor alpha mediates neuronal differentiation and neuroprotection in PC12 cells: Critical role of the A/B domain of the receptor . J. Mol. Endocrinol. , 35 : 257 – 67 .
   PubMed Web of Science ®Google Scholar
• Merot , Y. , Ferriere , F. , Gailhouste , L. , Huet , G. , Percevault , F. , Saligaut , C. and Flouriot , G. 2009 . Different outcomes of unliganded and liganded estrogen receptor-alpha on neurite outgrowth in PC12 cells . Endocrinology , 150 : 200 – 11 .
   PubMed Web of Science ®Google Scholar
• Metzger , D. , Ali , S. , Bornert , J. M. and Chambon , P. 1995 . Characterization of the amino-terminal transcriptional activation function of the human estrogen receptor in animal and yeast cells . J. Biol. Chem. , 270 : 9535 – 42 .
   PubMedGoogle Scholar
• Miller , N. R. , Jover , T. , Cohen , H. W. , Zukin , R. S. and Etgen , A. M. 2005 . Estrogen can act via estrogen receptor alpha and beta to protect hippocampal neurons against global ischemia-induced cell death . Endocrinology , 146 : 3070 – 79 .
   PubMed Web of Science ®Google Scholar
• Milner , T. A. , Ayoola , K. , Drake , C. T. , Herrick , S. P. , Tabori , N. E. , McEwen , B. S. , Warrier , S. and Alves , S. E. 2005 . Ultrastructural localization of estrogen receptor beta immunoreactivity in the rat hippocampal formation . J. Comp. Neurol. , 491 : 81 – 95 .
   PubMed Web of Science ®Google Scholar
• Mize , A. L. , Poisner , A. M. and Alper , R. H. 2001 . Estrogens act in rat hippocampus and frontal cortex to produce rapid, receptor-mediated decreases in serotonin 5-HT(1A) receptor function . Neuroendocrinology , 73 : 166 – 74 .
   PubMed Web of Science ®Google Scholar
• Mize , A. L. , Shapiro , R. A. and Dorsa , D. M. 2003 . Estrogen receptor-mediated neuroprotection from oxidative stress requires activation of the mitogen-activated protein kinase pathway . Endocrinology , 144 : 306 – 12 .
   PubMed Web of Science ®Google Scholar
• Mong , J. A. and Blutstein , T. 2006 . Estradiol modulation of astrocytic form and function: Implications for hormonal control of synaptic communication . Neuroscience , 138 : 967 – 75 .
   PubMed Web of Science ®Google Scholar
• Moreira , D. S. , Aquino , S. F. , Afonso , R. J. , Santos , E. P. and de Padua , V. L. 2009 . Occurrence of endocrine disrupting compounds in water sources of Belo Horizonte Metropolitan Area, Brazil . Environ. Technol. , 30 : 1041 – 49 .
   PubMed Web of Science ®Google Scholar
• Mukai , H. , Tsurugizawa , T. , Murakami , G. , Kominami , S. , Ishii , H. , Ogiue-Ikeda , M. , Takata , N. , Tanabe , N. , Furukawa , A. , Hojo , Y. , Ooishi , Y. , Morrison , J.H. , Janssen , W. G. , Rose , J. A. , Chambon , P. , Kato , S. , Izumi , S. , Yamazaki , T. , Kimoto , T. and Kawato , S. 2007 . Rapid modulation of long-term depression and spinogenesis via synaptic estrogen receptors in hippocampal principal neurons . J. Neurochem. , 100 : 950 – 67 .
   PubMed Web of Science ®Google Scholar
• Murphy , D. D. , Cole , N. B. and Segal , M. 1998 . Brain-derived neurotrophic factor mediates estradiol-induced dendritic spine formation in hippocampal neurons . Proc. Natl. Acad. Sci. USA , 95 : 11412 – 17 .
   PubMed Web of Science ®Google Scholar
• Negishi , T. , Ishii , Y. , Kyuwa , S. , Kuroda , Y. and Yoshikawa , Y. 2003 . Inhibition of staurosporine-induced neuronal cell death by bisphenol A and nonylphenol in primary cultured rat hippocampal and cortical neurons . Neurosci. Lett. , 353 : 99 – 102 .
   PubMed Web of Science ®Google Scholar
• Negishi , T. , Kawasaki , K. , Suzaki , S. , Maeda , H. , Ishii , Y. , Kyuwa , S. , Kuroda , Y. and Yoshikawa , Y. 2004 . Behavioral alterations in response to fear-provoking stimuli and tranylcypromine induced by perinatal exposure to bisphenol A and nonylphenol in male rats . Environ. Health Perspect , 112 : 1159 – 64 .
   PubMed Web of Science ®Google Scholar
• Nilsen , J. , Mor , G. and Naftolin , F. 1998 . Raloxifene induces neurite outgrowth in estrogen receptor positive PC12 cells . Menopause , 5 : 211 – 16 .
   PubMed Web of Science ®Google Scholar
• Ogiue-Ikeda , M. , Tanabe , N. , Mukai , H. , Hojo , Y. , Murakami , G. , Tsurugizawa , T. , Takata , N. , Kimoto , T. and Kawato , S. 2008 . Rapid modulation of synaptic plasticity by estrogens as well as endocrine disrupters in hippocampal neurons . Brain Res. Rev. , 57 : 363 – 75 .
   PubMed Web of Science ®Google Scholar
• Palmer , P. M. , Wilson , L. R. , Casey , A. C. and Wagner , R. E. 2010 . Occurrence of PCBs in raw and finished drinking water at seven public water systems along the Hudson River . Environ. Monit. Assess. , [Epub ahead of print]
   Web of Science ®Google Scholar
• Park , S. H. , Jang , J. H. , Chen , C. Y. , Na , H. K. and Surh , Y. J. 2010 . A formulated red ginseng extract rescues PC12 cells from PCB-induced oxidative cell death through Nrf2-mediated upregulation of heme oxygenase-1 and glutamate cysteine ligase . Toxicology. , [Epub ahead of print]
   Web of Science ®Google Scholar
• Payne , J. , Rajapakse , N. , Wilkins , M. and Kortenkamp , A. 2000 . Prediction and assessment of the effects of mixtures of four xenoestrogens . Environ. Health Perspect , 108 : 983 – 87 .
   PubMed Web of Science ®Google Scholar
• Pendaries , C. , Darblade , B. , Rochaix , P. , Krust , A. , Chambon , P. , Korach , K. S. , Bayard , F. and Arnal , J. F. 2002 . The AF-1 activation-function of ERalpha may be dispensable to mediate the effect of estradiol on endothelial NO production in mice . Proc. Natl. Acad. Sci. USA , 99 : 2205 – 10 .
   PubMed Web of Science ®Google Scholar
• Penot , G. , Le Peron , C. , Merot , Y. , Grimaud-Fanouillere , E. , Ferriere , F. , Boujrad , N. , Kah , O. , Saligaut , C. , Ducouret , B. , Metivier , R. and Flouriot , G. 2005 . The human estrogen receptor-alpha isoform hERalpha46 antagonizes the proliferative influence of hERalpha66 in MCF7 breast cancer cells . Endocrinology , 146 : 5474 – 84 .
   PubMed Web of Science ®Google Scholar
• Petit , F. , Le Goff , P. , Cravedi , J. P. , Valotaire , Y. and Pakdel , F. 1997 . Two complementary bioassays for screening the estrogenic potency of xenobiotics: Recombinant yeast for trout estrogen receptor and trout hepatocyte cultures . J. Mol. Endocrinol. , 19 : 321 – 35 .
   PubMed Web of Science ®Google Scholar
• Pike , C. J. , Carroll , J. C. , Rosario , E. R. and Barron , A. M. 2009 . Protective actions of sex steroid hormones in Alzheimer's disease . Front. Neuroendocrinol. , 30 : 239 – 58 .
   PubMed Web of Science ®Google Scholar
• Pike , M. C. , Krailo , M. D. , Henderson , B. E. , Casagrande , J. T. and Hoel , D. G. 1983 . ‘Hormonal’ risk factors, ‘breast tissue age’ and the age-incidence of breast cancer . Nature , 303 : 767 – 70 .
   PubMed Web of Science ®Google Scholar
• Poirier , J. , Hess , M. , May , P. C. and Finch , C. E. 1991 . Astrocytic apolipoprotein E mRNA and GFAP mRNA in hippocampus after entorhinal cortex lesioning . Brain Res. Mol. Brain Res. , 11 : 97 – 106 .
   PubMedGoogle Scholar
• Radio , N. M. , Breier , J. M. , Shafer , T. J. and Mundy , W. R. 2008 . Assessment of chemical effects on neurite outgrowth in PC12 cells using high content screening . Toxicol. Sci. , 105 : 106 – 18 .
   PubMed Web of Science ®Google Scholar
• Rubanyi , G. M. , Freay , A. D. , Kauser , K. , Sukovich , D. , Burton , G. , Lubahn , D. B. , Couse , J. F. , Curtis , S. W. and Korach , K. S. 1997 . Vascular estrogen receptors and endothelium-derived nitric oxide production in the mouse aorta. Gender difference and effect of estrogen receptor gene disruption . J. Clin. Invest , 99 : 2429 – 37 .
   PubMed Web of Science ®Google Scholar
• Sabbah , M. , Courilleau , D. , Mester , J. and Redeuilh , G. 1999 . Estrogen induction of the cyclin D1 promoter: involvement of a cAMP response-like element . Proc. Natl. Acad. Sci. USA , 96 : 11217 – 22 .
   PubMed Web of Science ®Google Scholar
• Safe , S. 2001 . Transcriptional activation of genes by 17 beta-estradiol through estrogen receptor-Sp1 interactions . Vitam. Horm. , 62 : 231 – 52 .
   PubMed Web of Science ®Google Scholar
• Sanfilippo , K. , Pinto , B. , Colombini , M.P. , Bartolucci , U. and Reali , D. 2010 . Determination of trace endocrine disruptors in ultrapure water for laboratory use by the yeast estrogen screen (YES) and chemical analysis (GC/MS) . J. Chromatogr. B Anal. Technol. Biomed. Life Sci. , 878 : 1190 – 94 .
   PubMed Web of Science ®Google Scholar
• Sato , K. , Akaishi , T. , Matsuki , N. , Ohno , Y. and Nakazawa , K. 2007 . beta-Estradiol induces synaptogenesis in the hippocampus by enhancing brain-derived neurotrophic factor release from dentate gyrus granule cells . Brain Res. , 1150 : 108 – 20 .
   PubMed Web of Science ®Google Scholar
• Sawada , H. , Ibi , M. , Kihara , T. , Urushitani , M. , Honda , K. , Nakanishi , M. , Akaike , A. and Shimohama , S. 2000 . Mechanisms of antiapoptotic effects of estrogens in nigral dopaminergic neurons . FASEB J. , 14 : 1202 – 14 .
   PubMed Web of Science ®Google Scholar
• Sawada , H. and Shimohama , S. 2003 . Estrogens and Parkinson disease: novel approach for neuroprotection . Endocrine , 21 : 77 – 79 .
   PubMed Web of Science ®Google Scholar
• Seifer , D. B. , Roa-Peña , L. , Keefe , D. L. , Zhang , H. , Goodman , S. , Jones , E. E. and Naftolin , F. 1994 . Increasing hypothalamic arcuate nucleus glial peroxidase activity in aging female rats is reduced by an antiestrogen and a gonadotropin-releasing hormone agonist . Menopause , 1 : 83 – 90 .
   Web of Science ®Google Scholar
• Serghini , R. , Froissard , P. , Sola , B. and Duval , D. 1994 . Cycloheximide and actinomycin D block the toxic effect of glutamic acid on PC12 cells . Neuroreport , 6 : 29 – 32 .
   PubMed Web of Science ®Google Scholar
• Shimokawa , N. , Miyazaki , W. , Iwasaki , T. and Koibuchi , N. 2006 . Low dose hydroxylated PCB induces c-Jun expression in PC12 cells . Neurotoxicology , 27 : 176 – 83 .
   PubMed Web of Science ®Google Scholar
• Shinomiya , N. and Shinomiya , M. 2003 . Dichlorodiphenyltrichloroethane suppresses neurite outgrowth and induces apoptosis in PC12 pheochromocytoma cells . Toxicol. Lett. , 137 : 175 – 83 .
   PubMed Web of Science ®Google Scholar
• Shughrue , P. J. and Dorsa , D. M. 1993 . Estrogen modulates the growth-associated protein GAP-43 (neuromodulin) mRNA in the rat preoptic area and basal hypothalamus . Neuroendocrinology , 57 : 439 – 47 .
   PubMed Web of Science ®Google Scholar
• Shughrue , P. J. , Lane , M. V. and Merchenthaler , I. 1997 . Comparative distribution of estrogen receptor-alpha and -beta mRNA in the rat central nervous system . J. Comp. Neurol. , 388 : 507 – 25 .
   PubMed Web of Science ®Google Scholar
• Shughrue , P. J. and Merchenthaler , I. 2003 . Estrogen prevents the loss of CA1 hippocampal neurons in gerbils after ischemic injury . Neuroscience , 116 : 851 – 61 .
   PubMed Web of Science ®Google Scholar
• Slotkin , T. A. and Seidler , F. J. 2009a . Benzo[a]pyrene impairs neurodifferentiation in PC12 cells . Brain Res. Bull. , 80 : 17 – 21 .
   PubMed Web of Science ®Google Scholar
• Slotkin , T. A. and Seidler , F. J. 2009b . Oxidative and excitatory mechanisms of developmental neurotoxicity: Transcriptional profiles for chlorpyrifos, diazinon, dieldrin, and divalent nickel in PC12 cells . Environ. Health Perspect , 117 : 587 – 96 .
   PubMed Web of Science ®Google Scholar
• Soares , R. , Guo , S. , Russo , J. and Schmitt , F. 2003 . Role of the estrogen antagonist ICI 182,780 in vessel assembly and apoptosis of endothelial cells . Ultrastruct. Pathol. , 27 : 33 – 39 .
   PubMed Web of Science ®Google Scholar
• Sohrabji , F. , Greene , L. A. , Miranda , R. C. and Toran-Allerand , C. D. 1994 . Reciprocal regulation of estrogen and NGF receptors by their ligands in PC12 cells . J. Neurobiol , 25 : 974 – 88 .
   PubMedGoogle Scholar
• Soto , A. M. , Rubin , B. S. and Sonnenschein , C. 2009 . Interpreting endocrine disruption from an integrative biology perspective . Mol. Cell. Endocrinol , 304 : 3 – 7 .
   PubMed Web of Science ®Google Scholar
• Soto , A. M. , Sonnenschein , C. , Chung , K. L. , Fernandez , M. F. , Olea , N. and Serrano , F. O. 1995 . The E-SCREEN assay as a tool to identify estrogens: An update on estrogenic environmental pollutants . Environ. Health Perspect , 103 ( suppl. 7 ) : 113 – 22 .
   PubMed Web of Science ®Google Scholar
• Staub , C. , Rauch , M. , Ferriere , F. , Trepos , M. , Dorval-Coiffec , I. , Saunders , P. T. , Cobellis , G. , Flouriot , G. , Saligaut , C. and Jegou , B. 2005 . Expression of estrogen receptor ESR1 and its 46-kDa variant in the gubernaculum testis . Biol. Reprod. , 73 : 703 – 12 .
   PubMed Web of Science ®Google Scholar
• Stice , J. P. , Lee , J. S. , Pechenino , A. S. and Knowlton , A. A. 2009 . Estrogen, aging and the cardiovascular system . Future Cardiol , 5 : 93 – 103 .
   PubMedGoogle Scholar
• Takahashi , N. , Tonchev , A. B. , Koike , K. , Murakami , K. , Yamada , K. , Yamashima , T. and Inoue , M. 2004 . Expression of estrogen receptor-beta in the postischemic monkey hippocampus . Neurosci. Lett , 369 : 9 – 13 .
   PubMed Web of Science ®Google Scholar
• Tavolari , S. , Bucci , L. , Tomasi , V. and Guarnieri , T. 2006 . Selected polychlorobiphenyls congeners bind to estrogen receptor alpha in human umbilical vascular endothelial (HUVE) cells modulating angiogenesis . Toxicology , 218 : 67 – 74 .
   PubMed Web of Science ®Google Scholar
• Tenenbaum , M. , Azab , A. N. and Kaplanski , J. 2007 . Effects of estrogen against LPS-induced inflammation and toxicity in primary rat glial and neuronal cultures . J. Endotoxin Res. , 13 : 158 – 66 .
   PubMedGoogle Scholar
• Teyssier , C. , Belguise , K. , Galtier , F. and Chalbos , D. 2001 . Characterization of the physical interaction between estrogen receptor alpha and JUN proteins . J. Biol. Chem. , 276 : 36361 – 69 .
   PubMed Web of Science ®Google Scholar
• Tiwari-Woodruff , S. and Voskuhl , R. R. 2009 . Neuroprotective and anti-inflammatory effects of estrogen receptor ligand treatment in mice . J. Neurol. Sci. , 286 : 81 – 85 .
   PubMed Web of Science ®Google Scholar
• Tofighi , R. , Johansson , C. , Goldoni , M. , Ibrahim , W. N. , Gogvadze , V. , Mutti , A. and Ceccatelli , S. 2010 . Hippocampal neurons exposed to the environmental contaminants methylmercury and polychlorinated biphenyls undergo cell death via parallel activation of calpains and lysosomal proteases . Neurotox. Res. , [Epub ahead of print]
   PubMed Web of Science ®Google Scholar
• Tora , L. , White , J. , Brou , C. , Tasset , D. , Webster , N. , Scheer , E. and Chambon , P. 1989 . The human estrogen receptor has two independent nonacidic transcriptional activation functions . Cell , 59 : 477 – 87 .
   PubMed Web of Science ®Google Scholar
• Toran-Allerand , C. D. 1980 . Sex steroids and the development of the newborn mouse hypothalamus and preoptic area in vitro. II. Morphological correlates and hormonal specificity . Brain Res. , 189 : 413 – 27 .
   PubMed Web of Science ®Google Scholar
• Toran-Allerand , C. D. , Miranda , R. C. , Hochberg , R. B. and MacLusky , N. J. 1992 . Cellular variations in estrogen receptor mRNA translation in the developing brain: Evidence from combined [125I]estrogen autoradiography and non-isotopic in situ hybridization histochemistry . Brain Res. , 576 : 25 – 41 .
   PubMed Web of Science ®Google Scholar
• Toran-Allerand , C. D. , Singh , M. and Setalo , G. Jr . 1999 . Novel mechanisms of estrogen action in the brain: New players in an old story . Front. Neuroendocrinol. , 20 : 97 – 121 .
   PubMed Web of Science ®Google Scholar
• Tsai , K. S. , Yang , R. S. and Liu , S. H. 2004 . Benzo[a]pyrene regulates osteoblast proliferation through an estrogen receptor-related cyclooxygenase-2 pathway . Chem. Res. Toxicol. , 17 : 679 – 84 .
   PubMed Web of Science ®Google Scholar
• Turgeon , J. L. , McDonnell , D. P. , Martin , K. A. and Wise , P. M. 2004 . Hormone therapy: Physiological complexity belies therapeutic simplicity . Science , 304 : 1269 – 73 .
   PubMed Web of Science ®Google Scholar
• Van den Belt , K. , Berckmans , P. , Vangenechten , C. , Verheyen , R. and Witters , H. 2004 . Comparative study on the in vitro/in vivo estrogenic potencies of 17beta-estradiol, estrone, 17alpha-ethynylestradiol and nonylphenol . Aquat. Toxicol. , 66 : 183 – 95 .
   PubMed Web of Science ®Google Scholar
• Vasudevan , N. and Pfaff , D. W. 2007 . Membrane-initiated actions of estrogens in neuroendocrinology: Emerging principles . Endocr. Rev. , 28 : 1 – 19 .
   PubMed Web of Science ®Google Scholar
• Vaudry , D. , Chen , Y. , Hsu , C. M. and Eiden , L. E. 2002a . PC12 cells as a model to study the neurotrophic activities of PACAP . Ann. NY Acad. Sci. , 971 : 491 – 96 .
   PubMed Web of Science ®Google Scholar
• Vaudry , D. , Stork , P. J. , Lazarovici , P. and Eiden , L. E. 2002b . Signaling pathways for PC12 cell differentiation: Making the right connections . Science , 296 : 1648 – 49 .
   PubMed Web of Science ®Google Scholar
• Vegeto , E. , Belcredito , S. , Etteri , S. , Ghisletti , S. , Brusadelli , A. , Meda , C. , Krust , A. , Dupont , S. , Ciana , P. , Chambon , P. and Maggi , A. 2003 . Estrogen receptor-alpha mediates the brain antiinflammatory activity of estradiol . Proc. Natl. Acad. Sci. USA , 100 : 9614 – 19 .
   PubMed Web of Science ®Google Scholar
• Wang , L. , Andersson , S. , Warner , M. and Gustafsson , J. A. 2001 . Morphological abnormalities in the brains of estrogen receptor beta knockout mice . Proc. Natl. Acad. Sci. USA , 98 : 2792 – 96 .
   PubMed Web of Science ®Google Scholar
• Wang , L. , Andersson , S. , Warner , M. and Gustafsson , J. A. 2003 . Estrogen receptor (ER)beta knockout mice reveal a role for ERbeta in migration of cortical neurons in the developing brain . Proc. Natl. Acad. Sci. USA , 100 : 703 – 8 .
   PubMed Web of Science ®Google Scholar
• Wang , X. , Dykens , J. A. , Perez , E. , Liu , R. , Yang , S. , Covey , D. F. and Simpkins , J. W. 2006 . Neuroprotective effects of 17beta-estradiol and nonfeminizing estrogens against H2O2 toxicity in human neuroblastoma SK-N-SH cells . Mol. Pharmacol. , 70 : 395 – 404 .
   PubMed Web of Science ®Google Scholar
• Webb , P. , Lopez , G. N. , Uht , R. M. and Kushner , P. J. 1995 . Tamoxifen activation of the estrogen receptor/AP-1 pathway: Potential origin for the cell-specific estrogen-like effects of antiestrogens . Mol. Endocrinol. , 9 : 443 – 56 .
   PubMed Web of Science ®Google Scholar
• Wilson , M. E. and Westberry , J. M. 2009 . Regulation of oestrogen receptor gene expression: New insights and novel mechanisms . J. Neuroendocrinol. , 21 : 238 – 42 .
   PubMed Web of Science ®Google Scholar
• Wise , P. M. and Dubal , D. B. 2000 . Estradiol protects against ischemic brain injury in middle-aged rats . Biol. Reprod. , 63 : 982 – 85 .
   PubMed Web of Science ®Google Scholar
• Witters , H. , Freyberger , A. , Smits , K. , Vangenechten , C. , Lofink , W. , Weimer , M. , Bremer , S. , Ahr , P. H. and Berckmans , P. 2010 . The assessment of estrogenic or anti-estrogenic activity of chemicals by the human stably transfected estrogen sensitive MELN cell line: Results of test performance and transferability . Reprod. Toxicol. , [Epub ahead of print]
   Web of Science ®Google Scholar
• Won , C. K. , Kim , M. O. and Koh , P. O. 2006 . Estrogen modulates Bcl-2 family proteins in ischemic brain injury . J. Vet. Med. Sci. , 68 : 277 – 80 .
   PubMed Web of Science ®Google Scholar
• Wooten , M. W. , Seibenhener , M. L. , Heikkila , J. E. and Mischak , H. 1998 . Delta-protein kinase C phosphorylation parallels inhibition of nerve growth factor-induced differentiation independent of changes in Trk A and MAP kinase signalling in PC12 cells . Cell Signal. , 10 : 265 – 76 .
   PubMed Web of Science ®Google Scholar
• Wu , T. W. , Wang , J. M. , Chen , S. and Brinton , R. D. 2005 . 17Beta-estradiol induced Ca2+ influx via L-type calcium channels activates the Src/ERK/cyclic-AMP response element binding protein signal pathway and BCL-2 expression in rat hippocampal neurons: A potential initiation mechanism for estrogen-induced neuroprotection . Neuroscience , 135 : 59 – 72 .
   PubMed Web of Science ®Google Scholar
• Yang , L. C. , Zhang , Q. G. , Zhou , C. F. , Yang , F. , Zhang , Y. D. , Wang , R. M. and Brann , D. W. 2010 . Extranuclear estrogen receptors mediate the neuroprotective effects of estrogen in the rat hippocampus . PLoS One , 5 : e9851
   Web of Science ®Google Scholar
• Yeh , I. T. 2007 . Postmenopausal hormone replacement therapy: Endometrial and breast effects . Adv. Anat. Pathol. , 14 : 17 – 24 .
   PubMed Web of Science ®Google Scholar
• Yokosuka , M. , Ohtani-Kaneko , R. , Yamashita , K. , Muraoka , D. , Kuroda , Y. and Watanabe , C. 2008 . Estrogen and environmental estrogenic chemicals exert developmental effects on rat hypothalamic neurons and glias . Toxicol. In Vitro , 2 : 1 – 9 .
   Google Scholar
• Yoon , Y. , Ryu , J. , Oh , J. , Choi , B. G. and Snyder , S. A. 2010 . Occurrence of endocrine disrupting compounds, pharmaceuticals, and personal care products in the Han River (Seoul, South Korea) . Sci. Total Environ , 408 : 636 – 43 .
   PubMed Web of Science ®Google Scholar
• York , R. D. , Molliver , D. C. , Grewal , S. S. , Stenberg , P. E. , McCleskey , E. W. and Stork , P. J. 2000 . Role of phosphoinositide 3-kinase and endocytosis in nerve growth factor-induced extracellular signal-regulated kinase activation via Ras and Rap1 . Mol. Cell Biol. , 20 : 8069 – 83 .
   PubMed Web of Science ®Google Scholar
• Yue , X. , Lu , M. , Lancaster , T. , Cao , P. , Honda , S. , Staufenbiel , M. , Harada , N. , Zhong , Z. , Shen , Y. and Li , R. 2005 . Brain estrogen deficiency accelerates Abeta plaque formation in an Alzheimer's disease animal model . Proc. Natl. Acad. Sci. USA , 102 : 19198 – 203 .
   PubMed Web of Science ®Google Scholar
• Zhang , Q. G. , Raz , L. , Wang , R. , Han , D. , De Sevilla , L. , Yang , F. , Vadlamudi , R. K. and Brann , D. W. 2009 . Estrogen attenuates ischemic oxidative damage via an estrogen receptor alpha-mediated inhibition of NADPH oxidase activation . J. Neurosci. , 29 : 13823 – 36 .
   PubMed Web of Science ®Google Scholar
• Zhao , L. and Brinton , R. D. 2007 . Estrogen receptor alpha and beta differentially regulate intracellular Ca(2+) dynamics leading to ERK phosphorylation and estrogen neuroprotection in hippocampal neurons . Brain Res. , 1172 : 48 – 59 .
   PubMed Web of Science ®Google Scholar