1,044
Views
44
CrossRef citations to date
0
Altmetric
Original Articles

Neuroendocrine Effects of Endocrine Disruptors in Teleost Fish

, , , &
Pages 370-386 | Published online: 26 Jul 2011

REFERENCES

  • Aluru , N. , Jorgensen , E. H. , Maule , A. G. and Vijayan , M. M. 2004 . PCB disruption of the hypothalamus–pituitary–interrenal axis involves brain glucocorticoid receptor downregulation in anadromous Arctic charr . Am. J. Physiol. Regul. Integr. Comp. Physiol , 287 : R787 – 93 .
  • Bakker , J. 2003 . Sexual differentiation of the neuroendocrine mechanisms regulating mate recognition in mammals . J. Neuroendocrinol , 15 : 615 – 21 .
  • Bakker , J. and Baum , M. J. 2008 . Role for estradiol in female-typical brain and behavioral sexual differentiation . Front. Neuroendocrinol , 29 : 1 – 16 .
  • Bakker , J. and Brock , O. 2010 . Early oestrogens in shaping reproductive networks: Evidence for a potential organisational role of oestradiol in female brain development . J. Neuroendocrinol , 22 : 728 – 35 .
  • Bakker , J. , Honda , S. , Harada , N. and Balthazart , J. 2002 . The aromatase knock-out mouse provides new evidence that estradiol is required during development in the female for the expression of sociosexual behaviors in adulthood . J. Neurosci , 22 : 9104 – 12 .
  • Bakker , J. , Pierman , S. and Gonzalez-Martinez , D. 2010 . Effects of aromatase mutation (ArKO) on the sexual differentiation of kisspeptin neuronal numbers and their activation by same versus opposite sex urinary pheromones . Hormones Behav , 57 : 390 – 95 .
  • Balthazart , J. 1990 . Brain aromatization of testosterone regulates male reproductive behavior in birds . Prog. Clin. Biol. Res , 342 : 92 – 98 .
  • Balthazart , J. , Absil , P. , Foidart , A. , Houbart , M. , Harada , N. and Ball , G. F. 1996 . Distribution of aromatase-immunoreactive cells in the forebrain of zebra finches (Taeniopygia guttata): Implications for the neural action of steroids and nuclear definition in the avian hypothalamus . J. Neurobiol , 31 : 129 – 48 .
  • Balthazart , J. and Ball , G. F. 1998 . New insights into the regulation and function of brain estrogen synthase (aromatase) . Trends Neurosci , 21 : 243 – 49 .
  • Bellingham , M. , Fowler , P. A. , Amezaga , M. R. , Rhind , S. M. , Cotinot , C. , Mandon-Pepin , B. , Sharpe , R. M. and Evans , N. P. 2009 . Exposure to a complex cocktail of environmental endocrine-disrupting compounds disturbs the kisspeptin/GPR54 system in ovine hypothalamus and pituitary gland . Environ. Health Perspect , 117 : 1556 – 62 .
  • Benito , S. , Fernandez , Y. , Mitjavila , S. , Moussa , M. , Anglade , F. and Periquet , A. 1997 . Phospholipid fatty acid composition affects enzymatic antioxidant defenses in cultured Swiss 3T3 fibroblasts . Redox Rep , 3 : 281 – 86 .
  • Bernard , D. J. , Bentley , G. E. , Balthazart , J. , Turek , F. W. and Ball , G. F. 1999 . Androgen receptor, estrogen receptor alpha, and estrogen receptor beta show distinct patterns of expression in forebrain song control nuclei of European starlings . Endocrinology , 140 : 4633 – 43 .
  • Bourguignon , J. P. , Rasier , G. , Lebrethon , M. C. , Gerard , A. , Naveau , E. and Parent , A. S. 2010 . Neuroendocrine disruption of pubertal timing and interactions between homeostasis of reproduction and energy balance . Mol. Cell. Endocrinol , 324 : 110 – 20 .
  • Cargouet , M. , Perdiz , D. , Mouatassim-Souali , A. , Tamisier-Karolak , S. and Levi , Y. 2004 . Assessment of river contamination by estrogenic compounds in Paris area (France) . Sci. Total Environ , 324 : 55 – 66 .
  • Chang , J. P. , Peter , R. E. and Crim , L. W. 1984 . Effects of dopamine and apomorphine on gonadotropin release from the transplanted pars distalis in goldfish . Gen. Comp. Endocrinol , 55 : 347 – 50 .
  • Cheshenko , K. , Pakdel , F. , Segner , H. , Kah , O. and Eggen , R. I. 2008 . Interference of endocrine disrupting chemicals with aromatase CYP19 expression or activity, and consequences for reproduction of teleost fish . Gen. Comp. Endocrinol , 155 : 31 – 62 .
  • Choi , S. M. , Yoo , S. D. and Lee , B. M. 2004 . Toxicological characteristics of endocrine-disrupting chemicals: Developmental toxicity, carcinogenicity and mutagenicity . J. Toxicol. Environ. Health B , 7 : 1 – 24 .
  • Choksi , N. Y. , Kodavanti , P. R. , Tilson , H. A. and Booth , R. G. 1997 . Effects of polychlorinated biphenyls (PCBs) on brain tyrosine hydroxylase activity and dopamine synthesis in rats . Fundam. Appl. Toxicol , 39 : 76 – 80 .
  • Chow , J. D. , Simpson , E. R. and Boon , W. C. 2009 . Alternative 5′-untranslated first exons of the mouse Cyp19A1 (aromatase) gene . J. Steroid Biochem. Mol. Biol , 115 : 115 – 25 .
  • Coe , T. S. , Hamilton , P. B. , Hodgson , D. , Paull , G. C. , Stevens , J. R. , Sumner , K. and Tyler , C. R. 2008 . An environmental estrogen alters reproductive hierarchies, disrupting sexual selection in group-spawning fish . Environ. Sci. Technol , 42 : 5020 – 25 .
  • Crews , D. , Gore , A. C. , Hsu , T. S. , Dangleben , N. L. , Spinetta , M. , Schallert , T. , Anway , M. D. and Skinner , M. K. 2007 . Transgenerational epigenetic imprints on mate preference . Proc. Natl. Acad. Sci. USA , 104 : 5942 – 46 .
  • De Roux , N. , Genin , E. , Carel , J. C. , Matsuda , F. , Chaussain , J. L. and Milgrom , E. 2003 . Hypogonadotropic hypogonadism due to loss of function of the KiSS1-derived peptide receptor GPR54 . Proc. Natl. Acad. Sci. USA , 100 : 10972 – 76 .
  • Diamanti-Kandarakis , E. , Bourguignon , J. P. , Giudice , L. C. , Hauser , R. , Prins , G. S. , Soto , A. M. , Zoeller , R. T. and Gore , A. C. 2009 . Endocrine-disrupting chemicals: An Endocrine Society scientific statement . Endocr. Rev , 30 : 293 – 42 .
  • Diotel , N. , Le Page , Y. , Mouriec , K. , Tong , S. K. , Pellegrini , E. , Vaillant , C. , Anglade , I. , Brion , F. , Pakdel , F. , Chung , B. C. and Kah , O. 2010 . Aromatase in the brain of teleost fish: Expression, regulation and putative functions . Front. Neuroendocrinol , 31 : 172 – 92 .
  • Garcia-Ovejero , D. , Azcoitia , I. , Doncarlos , L. L. , Melcangi , R. C. and Garcia-Segura , L. M. 2005 . Glia–neuron crosstalk in the neuroprotective mechanisms of sex steroid hormones . Brain Res. Brain Res. Rev , 48 : 273 – 86 .
  • Garcia-Segura , L. M. 2008 . Aromatase in the brain: Not just for reproduction anymore . J. Neuroendocrinol , 20 : 705 – 12 .
  • Garcia-Segura , L. M. , Wozniak , A. , Azcoitia , I. , Rodriguez , J. R. , Hutchison , R. E. and Hutchison , J. B. 1999 . Aromatase expression by astrocytes after brain injury: Implications for local estrogen formation in brain repair . Neuroscience , 89 : 567 – 78 .
  • Gaspar , P. , Cases , O. and Maroteaux , L. 2003 . The developmental role of serotonin: news from mouse molecular genetics . Nat. Rev. Neurosci , 4 : 1002 – 12 .
  • Gesto , M. , Tintos , A. , Rodriguez-Illamola , A. , Soengas , J. L. and Miguez , J. M. 2009 . Effects of naphthalene, beta-naphthoflavone and benzo(a)pyrene on the diurnal and nocturnal indoleamine metabolism and melatonin content in the pineal organ of rainbow trout, Oncorhynchus mykiss . Aquat. Toxicol , 92 : 1 – 8 .
  • Gesto , M. , Tintos , A. , Soengas , J. L. and Miguez , J. M. 2006 . Effects of acute and prolonged naphthalene exposure on brain monoaminergic neurotransmitters in rainbow trout (Oncorhynchus mykiss) . Comp. Biochem. Physiol. C Toxicol. Pharmacol , 144 : 173 – 83 .
  • Gonzalez , A. and Piferrer , F. 2003 . Aromatase activity in the European sea bass (Dicentrarchus labrax L.) brain. Distribution and changes in relation to age, sex, and the annual reproductive cycle . Gen. Comp. Endocrinol , 132 : 223 – 30 .
  • Gore , A. C. 2010 . Neuroendocrine targets of endocrine disruptors . Hormones (Athens) , 9 : 16 – 27 .
  • Gothilf , Y. , Munoz-Cueto , J. A. , Sagrillo , C. A. , Selmanoff , M. , Chen , T. T. , Kah , O. , Elizur , A. and Zohar , Y. 1996 . Three forms of gonadotropin-releasing hormone in a perciform fish (Sparus aurata): Complementary deoxyribonucleic acid characterization and brain localization . Biol. Reprod , 55 : 636 – 45 .
  • Hallgren , S. and Olsen , K. H. 2009 . Effects on guppy brain aromatase activity following short-term steroid and 4-nonylphenol exposures . Environ. Toxicol , 25 : 261 – 71 .
  • Halm , S. , Pounds , N. , Maddix , S. , Rand-Weaver , M. , Sumpter , J. P. , Hutchinson , T. H. and Tyler , C. R. 2002 . Exposure to exogenous 17beta-oestradiol disrupts p450aromB mRNA expression in the brain and gonad of adult fathead minnows (Pimephales promelas) . Aquat. Toxicol , 60 : 285 – 99 .
  • Herbison , A. E. 2009 . Rapid actions of oestrogen on gonadotropin-releasing hormone neurons; From fantasy to physiology? . J. Physiol , 587 : 5025 – 30 .
  • Herbison , A. E. , THorvath , T. L. , Naftolin , F. and Leranth , C. 1995 . Distribution of estrogen receptor-immunoreactive cells in monkey hypothalamus: Relationship to neurones containing luteinizing hormone-releasing hormone and tyrosine hydroxylase . Neuroendocrinology , 61 : 1 – 10 .
  • Herbison , A. E. and Theodosis , D. T. 1992 . Localization of oestrogen receptors in preoptic neurons containing neurotensin but not tyrosine hydroxylase, cholecystokinin or luteinizing hormone-releasing hormone in the male and female rat . Neuroscience , 50 : 283 – 98 .
  • Hill , R. A. and Boon , W. C. 2009 . Estrogens, brain, and behavior: Lessons from knockout mouse models . Semin. Reprod. Med , 27 : 218 – 28 .
  • Hill , R. A. , McInnes , K. J. , Gong , E. C. , Jones , M. E. , Simpson , E. R. and Boon , W. C. 2007 . Estrogen deficient male mice develop compulsive behavior . Biol. Psychiatry , 61 : 359 – 66 .
  • Hinfray , N. , Palluel , O. , Turies , C. , Cousin , C. , Porcher , J. M. and Brion , F. 2006 . Brain and gonadal aromatase as potential targets of endocrine disrupting chemicals in a model species, the zebrafish (Danio rerio) . Environ. Toxicol , 21 : 332 – 37 .
  • Hutchinson , T. H. , Ankley , G. T. , Segner , H. and Tyler , C. R. 2006 . Screening and testing for endocrine disruption in fish-biomarkers as “signposts,” not “traffic lights,” in risk assessment . Environ. Health Perspect , 114 ( suppl. 1 ) : 106 – 114 .
  • Jacobs , B. L. and Azmitia , E. C. 1992 . Structure and function of the brain serotonin system . Physiol. Rev , 72 : 165 – 229 .
  • Kah , O. 2009 . “ Endocrine targets of the hypothalamus and pituitary ” . In Fish physiology , Edited by: Bernier , N. J. , Van Der Kraak , G. , Farrell , A. P. and Brauner , C. J. Vol. 28 , 75 – 112 . Burlington : Academic Press .
  • Kah , O. , Breton , B. , Dulka , J. G. , Nunez-Rodriguez , J. , Peter , R. E. , Corrigan , A. , Rivier , J. E. and Vale , W. W. 1986 . A reinvestigation of the Gn-RH (gonadotrophin-releasing hormone) systems in the goldfish brain using antibodies to salmon Gn-RH . Cell Tissue Res , 244 : 327 – 37 .
  • Kah , O. and Dufour , S. 2010 . “ Conserved and divergent features of reproductive neuroendocrinology in fish ” . In Hormones and reproduction of vertebrates, Vol. 1, Fishes , Edited by: Norris , D. O. and Lopez , K. H. 15 – 42 . San Diego, CA : Elsevier .
  • Kah , O. , Dulka , J. G. , Dubourg , P. , Thibault , J. and Peter , R. E. 1987 . Neuroanatomical substrate for the inhibition of gonadotrophin secretion in goldfish: Existence of a dopaminergic preoptico-hypophyseal pathway . Neuroendocrinology , 45 : 451 – 58 .
  • Kah , O. , Lethimonier , C. , Somoza , G. , Guilgur , L. G. , Vaillant , C. and Lareyre , J. J. 2007 . GnRH and GnRH receptors in metazoa: A historical, comparative, and evolutive perspective . Gen. Comp. Endocrinol , 153 : 346 – 64 .
  • Kah , O. , Pellegrini , E. , Mouriec , K. , Diotel , N. , Anglade , I. , Vaillant , C. , Thieulant , M. L. , Tong , S. K. , Brion , F. , Chung , B. C. and Pakdel , F. 2009 . Oestrogens and neurogenesis: New functions for an old hormone. Lessons from the zebrafish . J. Soc. Biol , 203 : 29 – 38 .
  • Kah , O. , Pontet , A. , Danger , J. M. , Dubourg , P. , Pelletier , G. , Vaudry , H. and Calas , A. 1989 . Characterization, cerebral distribution, and gonadotrophin-release activity of neuorpeptide Y (NPY) in the goldfish . Fish Physiol. Biochem , 7 : 69 – 76 .
  • Kah , O. , Trudeau , V. L. , Sloley , B. D. , Chang , J. P. , Dubourg , P. , Yu , K. L. and Peter , R. E. 1992 . Influence of GABA on gonadotrophin release in the goldfish . Neuroendocrinology , 55 : 396 – 404 .
  • Kaiser , U. B. and Kuohung , W. 2005 . KiSS-1 and GPR54 as new players in gonadotropin regulation and puberty . Endocrine , 26 : 277 – 84 .
  • Kanda , S. , Akazome , Y. , Matsunaga , T. , Yamamoto , N. , Yamada , S. , Tsukamura , H. , Maeda , K. and Oka , Y. 2008 . Identification of KiSS-1 product kisspeptin and steroid-sensitive sexually dimorphic kisspeptin neurons in medaka (Oryzias latipes) . Endocrinology , 149 : 2467 – 76 .
  • Khan , I. A. , Mathews , S. , Okuzawa , K. , Kagawa , H. and Thomas , P. 2001 . Alterations in the GnRH-LH system in relation to gonadal stage and Aroclor 1254 exposure in Atlantic croaker . Comp. Biochem. Physiol. B Biochem. Mol. Biol , 129 : 251 – 59 .
  • Khan , I. A. and Thomas , P. 1992 . Stimulatory effects of serotonin on maturational gonadotropin release in the Atlantic croaker, Micropogonias undulatus . Gen. Comp. Endocrinol , 88 : 388 – 96 .
  • Khan , I. A. and Thomas , P. 1997 . Aroclor 1254-induced alterations in hypothalamic monoamine metabolism in the Atlantic croaker (Micropogonias undulatas): correlation with pituitary gonadotropin release . Neurotoxicology , 18 : 553 – 60 .
  • Khan , I. A. and Thomas , P. 2001 . Disruption of neuroendocrine control of luteinizing hormone secretion by Aroclor 1254 involves inhibition of hypothalamic tryptophan hydroxylase activity . Biol. Reprod , 64 : 955 – 64 .
  • Khan , I. A. and Thomas , P. 2006 . PCB congener-specific disruption of reproductive neuroendocrine function in Atlantic croaker . Mar. Environ. Res , 62 ( suppl. ) : S25 – 28 .
  • Kitahashi , T. , Ogawa , S. and Parhar , I. S. 2009 . Cloning and expression of kiss2 in the zebrafish and medaka . Endocrinology , 150 : 821 – 31 .
  • Kloas , W. , Urbatzka , R. , Opitz , R. , Wurtz , S. , Behrends , T. , Hermelink , B. , Hofmann , F. , Jagnytsch , O. , Kroupova , H. , Lorenz , C. , Neumann , N. , Pietsch , C. , Trubiroha , A. , Van Ballegooy , C. , Wiedemann , C. and Lutz , I. 2009 . Endocrine disruption in aquatic vertebrates . Ann. NY Acad. Sci , 1163 : 187 – 200 .
  • Kortner , T. M. , Mortensen , A. S. , Hansen , M. D. and Arukwe , A. 2009 . Neural aromatase transcript and protein levels in Atlantic salmon (Salmo salar) are modulated by the ubiquitous water pollutant, 4-nonylphenol . Gen. Comp. Endocrinol , 164 : 91 – 99 .
  • Kuhl , A. J. and Brouwer , M. 2006 . Antiestrogens inhibit xenoestrogen-induced brain aromatase activity but do not prevent xenoestrogen-induced feminization in Japanese medaka (Oryzias latipes) . Environ. Health Perspect , 114 : 500 – 6 .
  • Le Page , Y. , Menuet , A. , Kah , O. and Pakdel , F. 2008 . Characterization of a cis-acting element involved in cell-specific expression of the zebrafish brain aromatase gene . Mol. Reprod. Dev , 75 : 1549 – 57 .
  • Le Page , Y. , Scholze , M. , Kah , O. and Pakdel , F. 2006 . Assessment of xenoestrogens using three distinct estrogen receptors and the zebrafish brain aromatase gene in a highly responsive glial cell system . Environ. Health Perspect , 114 : 752 – 58 .
  • Lee , Y. M. , Seo , J. S. , Kim , I. C. , Yoon , Y. D. and Lee , J. S. 2006 . Endocrine disrupting chemicals (bisphenol A, 4-nonylphenol, 4-tert-octylphenol) modulate expression of two distinct cytochrome P450 aromatase genes differently in gender types of the hermaphroditic fish Rivulus marmoratus . Biochem. Biophys. Res. Commun , 345 : 894 – 903 .
  • Lethimonier , C. , Madigou , T. , Munoz-Cueto , J. A. , Lareyre , J. J. and Kah , O. 2004 . Evolutionary aspects of GnRHs, GnRH neuronal systems and GnRH receptors in teleost fish . Gen. Comp. Endocrinol , 135 : 1 – 16 .
  • Levavi-Sivan , B. , Bogerd , J. , Mananos , E. L. , Gomez , A. and Lareyre , J. J. 2010 . Perspectives on fish gonadotropins and their receptors . Gen. Comp. Endocrinol , 165 : 412 – 37 .
  • Linderoth , M. , Norman , A. , Noaksson , E. , Zebuhr , Y. , Norrgren , L. and Balk , L. 2006 . Steroid biosynthetic enzyme activities in leachate-exposed female perch (Perca fluviatilis) as biomarkers for endocrine disruption . Sci. Total Environ , 366 : 638 – 48 .
  • Liu , C. , Deng , J. , Yu , L. , Ramesh , M. and Zhou , B. 2009a . Endocrine disruption and reproductive impairment in zebrafish by exposure to 8:2 fluorotelomer alcohol . Aquat. Toxicol , 96 : 70 – 76 .
  • Liu , C. , Yu , L. , Deng , J. , Lam , P. K. , Wu , R. S. and Zhou , B. 2009b . Waterborne exposure to fluorotelomer alcohol 6:2 FTOH alters plasma sex hormone and gene transcription in the hypothalamic-pituitary-gonadal (HPG) axis of zebrafish . Aquat. Toxicol , 93 : 131 – 37 .
  • Losa , S. M. , Todd , K. L. , Sullivan , A. W. , Cao , J. , Mickens , J. A. and Patisaul , H. B. 2010 . Neonatal exposure to genistein adversely impacts the ontogeny of hypothalamic kisspeptin signaling pathways and ovarian development in the peripubertal female rat . Reprod. Toxicol , 31 ( 3 ) : 280 – 89 .
  • Lubzens , E. , Young , G. , Bobe , J. and Cerda , J. 2010 . Oogenesis in teleosts: How eggs are formed . Gen. Comp. Endocrinol , 165 : 367 – 89 .
  • Lyssimachou , A. , Jenssen , B. M. and Arukwe , A. 2006 . Brain cytochrome P450 aromatase gene isoforms and activity levels in Atlantic salmon after waterborne exposure to nominal environmental concentrations of the pharmaceutical ethynylestradiol and antifoulant tributyltin . Toxicol. Sci , 91 : 82 – 92 .
  • Martinez-Cerdeno , V. , Noctor , S. C. and Kriegstein , A. R. 2006 . Estradiol stimulates progenitor cell division in the ventricular and subventricular zones of the embryonic neocortex . Eur J. Neurosci , 24 : 3475 – 88 .
  • Matsumoto , T. , Honda , S. and Harada , N. 2003 . Neurological effects of aromatase deficiency in the mouse . J. Steroid Biochem. Mol. Biol , 86 : 357 – 65 .
  • McCarthy , M. M. , Schwarz , J. M. , Wright , C. L. and Dean , S. L. 2008 . Mechanisms mediating oestradiol modulation of the developing brain . J. Neuroendocrinol , 20 : 777 – 83 .
  • Mennigen , J. A. , Lado , W. E. , Zamora , J. M. , Duarte-Guterman , P. , Langlois , V. S. , Metcalfe , C. D. , Chang , J. P. , Moon , T. W. and Trudeau , V. L. 2010 . Waterborne fluoxetine disrupts the reproductive axis in sexually mature male goldfish, Carassius auratus . Aquat. Toxicol , 100 : 354 – 64 .
  • Mennigen , J. A. , Martyniuk , C. J. , Crump , K. , Xiong , H. , Zhao , E. , Popesku , J. , Anisman , H. , Cossins , A. R. , Xia , X. and Trudeau , V. L. 2008 . Effects of fluoxetine on the reproductive axis of female goldfish (Carassius auratus) . Physiol. Genom , 35 : 273 – 82 .
  • Mennigen , J. A. , Stroud , P. , Zamora , J. M. , Moon , T. W. and Trudeau , V. L. 2011 . Pharmaceuticals as neuroendocrine disruptors: Lessons learned from fish on Prozac . J. Toxicol. Environ. Health B , 14
  • Menuet , A. , Pellegrini , E. , Brion , F. , Gueguen , M. M. , Anglade , I. , Pakdel , F. and Kah , O. 2005 . Expression and estrogen-dependent regulation of the zebrafish brain aromatase gene . J. Comp. Neurol , 485 : 304 – 20 .
  • Mitani , Y. , Kanda , S. , Akazome , Y. , Zempo , B. and Oka , Y. 2010 . Hypothalamic Kiss1 but not Kiss2 neurons are involved in estrogen feedback in medaka (Oryzias latipes) . Endocrinology , 151 : 1751 – 59 .
  • Mouriec , K. , Gueguen , M. M. , Manuel , C. , Percevault , F. , Thieulant , M. L. , Pakdel , F. and Kah , O. 2009 . Androgens upregulate cyp19a1b (aromatase B) gene expression in the brain of zebrafish (Danio rerio) through estrogen receptors . Biol. Reprod , 80 : 889 – 96 .
  • Mouriec , K. , Pellegrini , E. , Anglade , I. , Menuet , A. , Adrio , F. , Thieulant , M. L.,. , Pakdel , F. and Kah , O. 2008 . Synthesis of estrogens in progenitor cells of adult fish brain: Evolutive novelty or exaggeration of a more general mechanism implicating estrogens in neurogenesis? . Brain Res. Bull , 75 : 274 – 80 .
  • Navas , J. M. , Anglade , I. , Bailhache , T. , Pakdel , F. , Breton , B. , Jego , P. and Kah , O. 1995 . Do gonadotrophin-releasing hormone neurons express estrogen receptors in the rainbow trout? A double immunohistochemical study . J. Comp. Neurol , 363 : 461 – 74 .
  • Pakdel , F. , Feon , S. , Le Gac , F. , Le Menn , F. and Valotaire , Y. 1991 . In vivo estrogen induction of hepatic estrogen receptor mRNA and correlation with vitellogenin mRNA in rainbow trout . Mol. Cell. Endocrinol , 75 : 205 – 12 .
  • Pakdel , F. , Le Guellec , C. , Vaillant , C. , Le Roux , M. G. and Valotaire , Y. 1989 . Identification and estrogen induction of two estrogen receptors (ER) messenger ribonucleic acids in the rainbow trout liver: sequence homology with other ERs . Mol. Endocrinol , 3 : 44 – 51 .
  • Pasmanik , M. and Callard , G. V. 1985 . Aromatase and 5 alpha-reductase in the teleost brain, spinal cord, and pituitary gland . Gen. Comp. Endocrinol , 60 : 244 – 51 .
  • Patisaul , H. B. , Todd , K. L. , Mickens , J. A. and Adewale , H. B. 2009 . Impact of neonatal exposure to the ER-alpha agonist PPT, bisphenol-A or phytoestrogens on hypothalamic kisspeptin fiber density in male and female rats . Neurotoxicology , 30 : 350 – 57 .
  • Pelissero , C. , Flouriot , G. , Foucher , J. L. , Bennetau , B. , Dunogues , J. , Le Gac , F. and Sumpter , J. P. 1993 . Vitellogenin synthesis in cultured hepatocytes; An in vitro test for the estrogenic potency of chemicals . J. Steroid Biochem. Mol. Biol , 44 : 263 – 72 .
  • Pellegrini , E. , Mouriec , K. , Anglade , I. , Menuet , A. , Le Page , Y. , Gueguen , M. M. , Marmignon , M. H. , Brion , F. , Pakdel , F. and Kah , O. 2007 . Identification of aromatase-positive radial glial cells as progenitor cells in the ventricular layer of the forebrain in zebrafish . J. Comp. Neurol , 501 : 150 – 67 .
  • Peter , R. E. , Chang , J. P. , Nahorniak , C. S. , Omeljaniuk , R. J. , Sokolowska , M. , Shih , S. H. and Billard , R. 1986 . Interactions of catecholamines and GnRH in regulation of gonadotropin secretion in teleost fish . Recent Prog. Hormone Res , 42 : 513 – 48 .
  • Petit , F. , Le Goff , P. , Cravedi , J. P. , Valotaire , Y. and Pakdel , F. 1997 . Two complementary bioassays for screening the estrogenic potency of xenobiotics: Recombinant yeast for trout estrogen receptor and trout hepatocyte cultures . J. Mol. Endocrinol , 19 : 321 – 35 .
  • Petit , F. , Valotaire , Y. and Pakdel , F. 1995 . Differential functional activities of rainbow trout and human estrogen receptors expressed in the yeast Saccharomyces cerevisiae . Eur J Biochem , 233 ( 2 ) : 584 – 92 .
  • Pierman , S. , Tirelli , E. , Douhard , Q. , Baum , M. J. and Bakker , J. 2006 . Male aromatase knockout mice acquire a conditioned place preference for cocaine but not for contact with an estrous female . Behav. Brain Res , 174 : 64 – 69 .
  • Rosenblum , P. M. and Peter , R. E. 1989 . Evidence for the involvement of endogenous opioids in the regulation of gonadotropin secretion in male goldfish . Carassius auratus. Gen. Comp. Endocrinol , 73 : 21 – 27 .
  • Schulz , R. W. , de Franca , L. R. , Lareyre , J. J. , Le Gac , F. , Chiarini-Garcia , H. , Nobrega , R. H. and Miura , T. 2010 . Spermatogenesis in fish . Gen. Comp. Endocrinol , 165 : 390 – 411 .
  • Seminara , S. B. , Messager , S. , Chatzidaki , E. E. , Thresher , R. R. , Acierno , J. S. Jr. , Shagoury , J. K. , Bo-Abbas , Y. , Kuohung , W. , Schwinof , K. M. , Hendrick , A. G. , Zahn , D. , Dixon , J. , Kaiser , U. B. , Slaugenhaupt , S. A. , Gusella , J. F. , O'Rahilly , S. , Carlton , M. B. , Crowley , W. F. Jr. , Aparicio , S. A. and Colledge , W. H. 2003 . The GPR54 gene as a regulator of puberty . N. Engl. J. Med , 349 : 1614 – 1627 .
  • Servili , A. , Le Page , Y. , Leprince , J. , Caraty , A. , Escobar , S. , Parha , I. S. , Seong , J. Y. , Vaudry , H. and Kah , O. 2011 . Organization of two independent kisspeptin systems derived from evolutionary-ancient kiss genes in the brain of zebrafish . Endocrinology , 152 ( 4 ) : 1527 – 40 .
  • Servili , A. , Lethimonier , C. , Lareyre , J. J. , Lopez-Olmeda , J. F. , Sanchez-Vazquez , F. J. , Kah , O. and Munoz-Cueto , J. A. 2010 . The highly conserved gonadotropin-releasing hormone-2 form acts as a melatonin-releasing factor in the pineal of a teleost fish, the European sea bass Dicentrarchus labrax . Endocrinology , 151 : 2265 – 75 .
  • Shivers , B. D. , Harlan , R. E. , Morrell , J. I. and Pfaff , D. W. 1983 . Absence of oestradiol concentration in cell nuclei of LHRH-immunoreactive neurones . Nature , 304 : 345 – 47 .
  • Simpson , E. R. , Zhao , Y. , Agarwal , V. R. , Michael , M. D. , Bulun , S. E. , Hinshelwood , M. M. , Graham-Lorence , S. , Sun , T. , Fisher , C. R. , Qin , K. and Mendelson , C. R. 1997 . Aromatase expression in health and disease . Recent Prog. Hormone Res , 52 : 185 – 213 . discussion 213–14
  • Somoza , G. M. , Yu , K. L. and Peter , R. E. 1988 . Serotonin stimulates gonadotropin release in female and male goldfish, Carassius auratus L . Gen. Comp. Endocrinol , 72 : 374 – 82 .
  • Sumpter , J. P. and Jobling , S. 1995 . Vitellogenesis as a biomarker for estrogenic contamination of the aquatic environment . Environ. Health Perspect , 103 ( suppl. 7 ) : 173 – 78 .
  • Tchoudakova , A. and Callard , G. V. 1998 . Identification of multiple CYP19 genes encoding different cytochrome P450 aromatase isozymes in brain and ovary . Endocrinology , 139 : 2179 – 89 .
  • Tchoudakova , A. , Kishida , M. , Wood , E. and Callard , G. V. 2001 . Promoter characteristics of two cyp19 genes differentially expressed in the brain and ovary of teleost fish . J. Steroid Biochem. Mol. Biol , 78 : 427 – 39 .
  • Ternes , T. A. , Kreckel , P. and Mueller , J. 1999 . Behaviour and occurrence of estrogens in municipal sewage treatment plants—II. Aerobic batch experiments with activated sludge . Sci. Total Environ , 225 : 91 – 99 .
  • Thomas , P. , Rahman , M. S. , Khan , I. A. and Kummer , J. A. 2007 . Widespread endocrine disruption and reproductive impairment in an estuarine fish population exposed to seasonal hypoxia . Proc. Biol. Sci , 274 : 2693 – 701 .
  • Tomy , S. , Wu , G. C. , Huang , H. R. and Chang , C. F. 2009 . Age-dependent differential expression of genes involved in steroid signalling pathway in the brain of protandrous black porgy . Acanthopagrus schlegeli. Dev. Neurobiol , 69 : 299 – 313 .
  • Tomy , S. , Wu , G. C. , Huang , H. R. , Dufour , S. and Chang , C. F. 2007 . Developmental expression of key steroidogenic enzymes in the brain of protandrous black porgy fish, Acanthopagrus schlegeli . J. Neuroendocrinol , 19 : 643 – 55 .
  • Tong , S. K. and Chung , B. C. 2003 . Analysis of zebrafish cyp19 promoters . J. Steroid Biochem. Mol. Biol , 86 : 381 – 86 .
  • Trudeau , V. L. , Spanswick , D. , Fraser , E. J. , Lariviere , K. , Crump , D. , Chiu , S. , MacMillan , M. and Schulz , R. W. 2000 . The role of amino acid neurotransmitters in the regulation of pituitary gonadotropin release in fish . Biochem. Cell Biol , 78 : 241 – 59 .
  • Tyler , C. R. , Jobling , S. and Sumpter , J. P. 1998 . Endocrine disruption in wildlife: A critical review of the evidence . Crit. Rev. Toxicol , 28 : 319 – 61 .
  • Tyler , C. R. , Lange , A. , Paull , G. C. , Katsu , Y. and Iguchi , T. 2007 . The roach (Rutilus rutilus) as a sentinel for assessing endocrine disruption . Environ. Sci , 14 : 235 – 53 .
  • Vaillant , C. , Le Guellec , C. , Pakdel , F. and Valotaire , Y. 1988 . Vitellogenin gene expression in primary culture of male rainbow trout hepatocytes . Gen. Comp. Endocrinol , 70 : 284 – 90 .
  • van der Ven , K. , Keil , D. , Moens , L. N. , Van Leemput , K. , van Remortel , P. and De Coen , W. M. 2006 . Neuropharmaceuticals in the environment: Mianserin-induced neuroendocrine disruption in zebrafish (Danio rerio) using cDNA microarrays . Environ. Toxicol. Chem , 25 : 2645 – 52 .
  • Vetillard , A. and Bailhache , T. 2005 . Cadmium: an endocrine disrupter that affects gene expression in the liver and brain of juvenile rainbow trout . Biol. Reprod , 72 : 119 – 26 .
  • Vitalis , T. and Parnavelas , J. G. 2003 . The role of serotonin in early cortical development . Dev. Neurosci , 25 : 245 – 56 .
  • Vizziano-Cantonnet , D. , Anglade , I. , Pellegrini , E. , Gueguen , M. M. , Fostier , A. , Guiguen , Y. and Kah , O. 2011 . Sexual dimorphism in the brain aromatase expression and activity, and in the central expression of other steroidogenic enzymes during the period of sex differentiation in monosex rainbow trout populations . Gen. Comp. Endocrinol , 170 : 346 – 55 .
  • Vosges , M. , Le Page , Y. , Chung , B. C. , Combarnous , Y. , Porcher , J. M. , Kah , O. and Brion , F. 2010 . 17-Alpha-ethinylestradiol disrupts the ontogeny of the forebrain GnRH system and the expression of brain aromatase during early development of zebrafish . Aquat. Toxicol , 99 : 479 – 91 .
  • Wang , L. , Andersson , S. , Warner , M. and Gustafsson , J. A. 2001 . Morphological abnormalities in the brains of estrogen receptor beta knockout mice . Proc. Natl. Acad. Sci. USA , 98 : 2792 – 96 .
  • Wang , L. , Andersson , S. , Warner , M. and Gustafsson , J. A. 2002 . Estrogen actions in the brain . Sci. STKE , 2002 : e29
  • Waters , E. M. and Simerly , R. B. 2009 . Estrogen induces caspase-dependent cell death during hypothalamic development . J. Neurosci , 29 : 9714 – 18 .
  • Waye , A. and Trudeau , V. L. 2011 . Neuroendocrine disruption: More than hormones are upset . J. Toxicol. Environ. Health. B , 14 : 270 – 291 .
  • Zikopoulos , B. , Kentouri , M. and Dermon , C. R. 2000 . Proliferation zones in the adult brain of a sequential hermaphrodite teleost species (Sparus aurata) . Brain Behav. Evol , 56 : 310 – 22 .
  • Zikopoulos , B. , Kentouri , M. and Dermon , C. R. 2001 . Cell genesis in the hypothalamus is associated to the sexual phase of a hermaphrodite teleost . Neuroreport , 12 : 2477 – 81 .
  • Zohar , Y. , Munoz-Cueto , J. A. , Elizur , A. and Kah , O. 2010 . Neuroendocrinology of reproduction in teleost fish . Gen. Comp. Endocrinol , 165 : 438 – 55 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.