Neuropeptides and Enzymes are Targets for the Action of Endocrine Disrupting Chemicals in the Vertebrate Brain

REFERENCES

• Adewale , H. B. , Todd , K. L. , Mickens , J. A. and Patisaul , H. B. 2011 . The impact of neonatal bisphenol-A exposure on sexually dimorphic hypothalamic nuclei in the female rat . Neurotoxicology , 32 : 38 – 49 .
   PubMed Web of Science ®Google Scholar
• Advis , J. P. , Klein , J. , Kuljis , R. O. , Sarkar , D. K. , McDonald , J. M. and Conover , C. A. 2003 . Regulation of gonadotropin releasing hormone release by neuropeptide Y at the median eminence during the preovulatory period in ewes . Neuroendocrinology , 77 : 246 – 57 .
   PubMed Web of Science ®Google Scholar
• Allen , J. M. 1990 . Molecular structure of neuropeptide Y . Ann. NY Acad. Sci. , 611 : 86 – 98 .
   PubMed Web of Science ®Google Scholar
• Allieri , F. , Spigolon , G. , Viglietti Panzica , C. , Garcia-Falgueras , A. , Guillamon , A. , Collado , P. and Panzica , G. C. 2005 . The Tfm rat, a model to study the influence of testosterone on the development of limbic vasopressinergci system . Trab. Inst. Cajal LXXX , : 198 – 199 .
   Google Scholar
• Argiolas , A. 1999 . Neuropeptides and sexual behaviour . Neurosci. Biobehav. Rev. , 23 : 1127 – 42 .
   PubMed Web of Science ®Google Scholar
• Arukwe , A. 2006 . Organ-specific patterns of P450arom gene isoforms are modulated by p,p'-DDE in adult male European common frog, Rana temporaria . Mar. Environ. Res. , 62 ( suppl. ) : S215 – 18 .
   Google Scholar
• Aste , N. , Panzica , G. C. , Aimar , P. , Viglietti-Panzica , C. , Harada , N. , Foidart , A. and Balthazart , J. 1994 . Morphometric studies demonstrate that aromatase-immunoreactive cells are the main target of androgens and estrogens in the quail medial preoptic nucleus . Exp. Brain Res. , 101 : 241 – 52 .
   PubMed Web of Science ®Google Scholar
• Aste , N. , Panzica , G. C. , Viglietti-Panzica , C. and Balthazart , J. 1991 . Effects of in ovo estradiol benzoate treatments on sexual behavior and size of neurons in the sexually dimorphic medial preoptic nucleus of Japanese quail . Brain Res. Bull. , 27 : 713 – 20 .
   PubMed Web of Science ®Google Scholar
• Atoji , Y. , Yamamoto , Y. and Suzuki , Y. 2001 . Distribution of NADPH diaphorase-containing neurons in the pigeon central nervous system . J. Chem. Neuroanat. , 21 : 1 – 22 .
   PubMed Web of Science ®Google Scholar
• Axelsson , J. , Mattsson , A. , Brunström , B. and Halldin , K. 2007 . Expression of estrogen receptor alpha and -beta mRNA in the brain of Japanese quail embryos . Dev. Neurobiol. , 67 : 1742 – 50 .
   PubMed Web of Science ®Google Scholar
• Azcoitia , I. , Moreno , A. , Carrero , P. , Palacios , S. and Garcia-Segura , L. M. 2006 . Neuroprotective effects of soy phytoestrogens in the rat brain . Gynecol. Endocrinol. , 22 : 63 – 69 .
   PubMed Web of Science ®Google Scholar
• Bale , T. L. and Dorsa , D. M. 1995 . Sex differences in and effects of estrogen on oxytocin receptor messenger ribonucleic acid expression in the ventromedial hypothalamus . Endocrinology , 136 : 27 – 32 .
   PubMed Web of Science ®Google Scholar
• Balthazart , J. , Baillien , M. , Charlier , T. D. and Ball , G. F. 2003 . Calcium-dependent phosphorylation processes control brain aromatase in quail . Eur. J. Neurosci. , 17 : 1591 – 1606 .
   PubMed Web of Science ®Google Scholar
• Balthazart , J. and Ball , G. F. 2006a . Is brain estradiol a hormone or a neurotransmitter? . Trends Neurosci. , 29 : 241 – 49 .
   PubMed Web of Science ®Google Scholar
• Balthazart , J. , Cornil , C. A. , Charlier , T. D. , Taziaux , M. and Ball , G. F. 2009 . Estradiol, a key endocrine signal in the sexual differentiation and activation of reproductive behavior in quail . J. Exp. Zool. A Ecol. Genet. Physiol. , 311 : 323 – 45 .
   PubMed Web of Science ®Google Scholar
• Balthazart , J. , Tlemçani , O. and Ball , G. F. 1996b . Do sex differences in the brain explain sex differences in the hormonal induction of reproductive behavior? What 25 years of research on the Japanese quail tells us . Hormone Behav. , 30 : 627 – 61 .
   PubMed Web of Science ®Google Scholar
• Balthazart , J. , Tlemçani , O. and Harada , N. 1996 . Localization of testosterone-sensitive and sexually dimorphic aromatase-immunoreactive cells in the quail preoptic area . J. Chem. Neuroanat. , 11 : 147 – 71 .
   PubMed Web of Science ®Google Scholar
• Bateman , H. L. and Patisaul , H. B. 2008 . Disrupted female reproductive physiology following neonatal exposure to phytoestrogens or estrogen specific ligands is associated with decreased GnRH activation and kisspeptin fiber density in the hypothalamus . Neurotoxicology , 29 : 988 – 97 .
   PubMed Web of Science ®Google Scholar
• Beck , B. 2000 . Neuropeptides and obesity . Nutrition , 16 : 916 – 23 .
   PubMed Web of Science ®Google Scholar
• Bellingham , M. , Fowler , P. A. , Amezaga , M. R. , Rhind , S. M. , Cotinot , C. , Mandon-Pepin , B. , Sharpe , R. M. and Evans , N. P. 2009 . Exposure to a complex cocktail of environmental endocrine-disrupting compounds disturbs the kisspeptin/GPR54 system in ovine hypothalamus and pituitary gland . Environ. Health Perspect. , 117 : 1556 – 62 .
   PubMed Web of Science ®Google Scholar
• Bo , E. , Sterchele , D. , Viglietti-Panzica , C. and Panzica , G. C. 2009 . “ Effect of endocrine disrupter TBT on mouse brain circuits controlling food intake ” . In Program 374.11/EE122 Neuroscience Meeting Planner , Chicago : Society for Neuroscience, Online .
   Google Scholar
• Bodo , C. , Kudwa , A. E. and Rissman , E. F. 2006 . Both estrogen receptor-alpha and -beta are required for sexual differentiation of the anteroventral periventricular area in mice . Endocrinology , 147 : 415 – 20 .
   PubMed Web of Science ®Google Scholar
• Boyd , S. K. 1994 . Gonadal steroid modulation of vasotocin concentrations in the bullfrog brain . Neuroendocrinology , 60 : 150 – 56 .
   PubMed Web of Science ®Google Scholar
• Bredt , D. S. and Snyder , S. H. 1992 . Nitric oxide, a novel neuronal messenger . Neuron , 8 : 3 – 11 .
   PubMed Web of Science ®Google Scholar
• Brüning , G. 1993 . Localization of NADPH-diaphorase in the brain of the chicken . J. Comp. Neurol. , 334 : 192 – 208 .
   PubMed Web of Science ®Google Scholar
• Brüning , G. , Katzbach , R. and Mayer , B. 1995 . Histochemical and immunocytochemical localization of nitric- oxide synthase in the central nervous system of the goldfish, Carassius auratus . J. Comp. Neurol. , 358 : 353 – 82 .
   PubMed Web of Science ®Google Scholar
• Brüning , G. and Mayer , B. 1996 . Localization of nitric oxide synthase in the brain of the frog, Xenopus laevis . Brain Res. , 741 : 331 – 343 .
   PubMed Web of Science ®Google Scholar
• Brüning , G. , Wiese , S. and Mayer , B. 1994 . Nitric oxide synthase in the brain of the turtle Pseudemys scripta elegans . J. Comp. Neurol. , 348 : 183 – 206 .
   PubMed Web of Science ®Google Scholar
• Carrillo , B. , Pinos , H. , Guillamon , A. , Panzica , G. C. and Collado , P. 2007 . Morphometrical and neurochemical changes in the anteroventral subdivision of the rat medial amygdala during estrus cycle . Brain Res. , 1150 : 83 – 93 .
   PubMed Web of Science ®Google Scholar
• Carter , C. S. 1998 . Neuroendocrine perspectives on social attachment and love . Psychoneuroendocrinology , 23 : 779 – 818 .
   PubMed Web of Science ®Google Scholar
• Ceccatelli , S. , Grandison , L. , Scott , R. E. M. , Pfaff , D. W. and Kow , L. M. 1996 . Estradiol regulation of nitric oxide synthase mRNAs in rat hypothalamus . Neuroendocrinology , 64 : 357 – 63 .
   PubMed Web of Science ®Google Scholar
• Cheng , S.-B. , Kuchiiwa , S. , Ren , X.-Q. , Gao , H.-Z. , Kuchiiwa , T. and Nakagawa , S. 2003 . Dioxin exposure down-regulates nitric oxide synthase and NADPH-diaphorase activities in the hypothalamus of Long-Evans rat . Neurosci. Lett. , 345 : 5 – 8 .
   PubMed Web of Science ®Google Scholar
• Cheshenko , K. , Brion , F. , Le Page , Y. , Hinfray , N. , Pakdel , F. , Kah , O. , Segner , H. and Eggen , R. I. 2007 . Expression of zebra fish aromatase cyp19a and cyp19b genes in response to the ligands of estrogen receptor and aryl hydrocarbon receptor . Toxicol. Sci. , 96 : 255 – 67 .
   PubMed Web of Science ®Google Scholar
• Cheshenko , K. , Pakdel , F. , Segner , H. , Kah , O. and Eggen , R. I. 2008 . Interference of endocrine disrupting chemicals with aromatase CYP19 expression or activity, and consequences for reproduction of teleost fish . Gen. Comp. Endocrinol. , 155 : 31 – 62 .
   PubMed Web of Science ®Google Scholar
• Chronwall , B. M. and Zukowska , Z. 2004 . Neuropeptide Y, ubiquitous and elusive . Peptides , 25 : 359 – 63 .
   PubMed Web of Science ®Google Scholar
• Chu , H. P. , Sarkar , G. and Etgen , A. M. 2004 . Estradiol and progesterone modulate the nitric oxide/cyclic gmp pathway in the hypothalamus of female rats and in GT1-1 cells . Endocrine , 24 : 177 – 84 .
   PubMed Web of Science ®Google Scholar
• Clark , J. T. , Kalra , P. S. and Kalra , S. P. 1985 . Neuropeptide Y stimulates feeding but inhibits sexual behavior in rats . Endocrinology , 117 : 2435 – 42 .
   PubMed Web of Science ®Google Scholar
• Clarkson , J. and Herbison , A. E. 2006 . Postnatal development of kisspeptin neurons in mouse hypothalamus; Sexual dimorphism and projections to gonadotropin-releasing hormone neurons . Endocrinology , 147 : 5817 – 25 .
   PubMed Web of Science ®Google Scholar
• Coburn , C. G. , Curras-Collazo , M. C. and Kodavanti , P. R. 2007 . Polybrominated diphenyl ethers and ortho-substituted polychlorinated biphenyls as neuroendocrine disruptors of vasopressin release: Effects during physiological activation in vitro and structure-activity relationships . Toxicol. Sci. , 98 : 178 – 86 .
   PubMed Web of Science ®Google Scholar
• Coburn , C. G. , Gillard , E. R. and Curras-Collazo , M. C. 2005 . Dietary exposure to aroclor 1254 alters central and peripheral vasopressin release in response to dehydration in the rat . Toxicol. Sci. , 84 : 149 – 56 .
   PubMed Web of Science ®Google Scholar
• Colciago , A. , Casati , L. , Mornati , O. , Vergoni , A. V. , Santagostino , A. , Celotti , F. and Negri-Cesi , P. 2009 . Chronic treatment with polychlorinated biphenyls (PCB) during pregnancy and lactation in the rat Part 2: Effects on reproductive parameters, on sex behavior, on memory retention and on hypothalamic expression of aromatase and 5alpha-reductases in the offspring . Toxicol. Appl. Pharmacol. , 239 : 46 – 54 .
   PubMed Web of Science ®Google Scholar
• Collado , P. , Guillamon , A. , Pinos , H. , Perez-Izquierdo , M. A. , Garcıa-Falgueras , A. , Carrillo , B. , Rodrıguez , C. and Panzica , G. C. 2003 . NADPH-diaphorase activity increases during estrous phase in the bed nucleus of the accessory olfactory tract in the female rat . Brain Res. , 983 : 223 – 29 .
   PubMed Web of Science ®Google Scholar
• Cozzi , B. , Massa , R. and Panzica , G. C. 1997 . The NADPH-diaphorase-containing system in the brain of the budgerigar (Melopsittacus undulatus) . Cell Tissue Res. , 287 : 101 – 12 .
   PubMed Web of Science ®Google Scholar
• De Graan , P. N. E. , Schotman , P. and Versteeg , D. H. G. 1990 . “ Neural mechanisms of action of neuropeptides: Macromolecules and neurotransmitters ” . In In Neuropeptides: Basics and perspectives , Edited by: De Wied , D. 139 – 164 . Amsterdam : Elsevier Science .
   Google Scholar
• De Vries , G. J. and Panzica , G. C. 2006 . Sexual differentiation of central vasopressin and vasotocin systems in vertebrates: different mechanisms, similar endpoints . Neuroscience , 138 : 947 – 955 .
   PubMed Web of Science ®Google Scholar
• De Vries , G. J. and Buijs , R. M. 1983 . The origin of the vasopressinergic and oxytocinergic innervation of the rat brain with special reference to the lateral septum . Brain Res. , 273 : 307 – 17 .
   PubMed Web of Science ®Google Scholar
• De Vries , G. J. , Buijs , R. M. and Sluiter , A. A. 1984a . Gonadal hormone actions on the morphology of the vasopressinergic innervation of the adult rat brain . Brain Res. , 298 : 141 – 45 .
   PubMed Web of Science ®Google Scholar
• De Vries , G. J. , Buijs , R. M. and Van Leeuwen , F. W. 1984b . Sex differences in vasopressin and other neurotransmitter systems in the brain . Prog. Brain Res. , 61 : 185 – 203 .
   PubMed Web of Science ®Google Scholar
• Della Seta , D. , Minder , I. , Dessi-Fulgheri , F. and Farabollini , F. 2005 . Bisphenol-A exposure during pregnancy and lactation affects maternal behavior in rats . Brain Res. Bull. , 65 : 255 – 60 .
   PubMed Web of Science ®Google Scholar
• Diotel , N. , Le Page , Y. , Mouriec , K. , Tong , S. K. , Pellegrini , E. , Vaillant , C. , Anglade , I. , Brion , F. , Pakdel , F. , Chung , B. C. and Kah , O. 2010 . Aromatase in the brain of teleost fish: Expression, regulation and putative functions . Front. Neuroendocrinol. , 31 : 172 – 92 .
   PubMed Web of Science ®Google Scholar
• Du , J. and Hull , E. M. 1999 . Effects of testosterone on neuronal nitric oxide synthase and tyrosine hydroxylase . Brain Res. , 836 : 90 – 98 .
   PubMed Web of Science ®Google Scholar
• Edelmann , M. , Wolfe , C. , Scordalakes , E. M. , Rissman , E. F. and Tobet , S. 2007 . Neuronal nitric oxide synthase and calbindin delineate sex differences in the developing hypothalamus and preoptic area . Dev. Neurobiol. , 67 : 1371 – 81 .
   PubMed Web of Science ®Google Scholar
• Engell , M. D. , Godwin , J. , Young , L. J. and Vandenbergh , J. G. 2006 . Perinatal exposure to endocrine disrupting compounds alters behavior and brain in the female pine vole . Neurotoxicol. Teratol. , 28 : 103 – 10 .
   PubMed Web of Science ®Google Scholar
• Eva , C. , Serra , M. , Mele , P. , Panzica , G. C. and Oberto , A. 2006 . Physiology and gene regulation of the brain NPY Y1 receptor . Front. Neuroendocrinol. , 27 : 308 – 39 .
   PubMed Web of Science ®Google Scholar
• Everts , H. G. J. , de Ruiter , A. J. and Koolhaas , J. M. 1997 . Differential lateral septal vasopressin in Wild-type rats: Correlation with aggression . Hormones Behav. , 31 : 136 – 44 .
   PubMed Web of Science ®Google Scholar
• Fabre-Nys , C. 1998 . Steroid control of monoamines in relation to sexual behaviour . Rev. Reprod. , 3 : 31 – 41 .
   PubMedGoogle Scholar
• Faqi , A. S. and Chahoud , I. 1998 . Antiestrogenic effects of low doses of 2,3,7,8-TCDD in offspring of female rats exposed throughout pregnancy and lactation . Bull. Environ. Contam. Toxicol. , 61 : 462 – 69 .
   PubMed Web of Science ®Google Scholar
• Ferguson , J. N. , Young , L. J. and Insel , T. R. 2002 . The neuroendocrine basis of social recognition . Front. Neuroendocrinol. , 23 : 200 – 24 .
   PubMed Web of Science ®Google Scholar
• Foidart , A. , Reid , J. , Absil , P. , Yoshimura , N. , Harada , N. and Balthazart , J. 1995 . Critical re-examination of the distribution of aromatase-immunoreactive cells in the quail forebrain using antibodies raised against human placental aromatase and against the recombinant quail, mouse or human enzyme . J. Chem. Neuroanat. , 8 : 267 – 82 .
   PubMed Web of Science ®Google Scholar
• Forstermann , U. , Closs , E. I. , Pollock , J. S. , Nakane , M. , Schwarz , P. , Gath , I. and Kleinert , H. 1994 . Nitric oxide synthase isozymes. Characterization, purification, molecular cloning, and functions . Hypertension , 23 : 1121 – 31 .
   PubMed Web of Science ®Google Scholar
• Garcia-Falgueras , A. , Pinos , H. , Collado , P. , Pasaro , E. , Fernandez , R. , Jordan , C. L. , Segovia , S. and Guillamon , A. 2005 . The role of the androgen receptor in CNS masculinization . Brain Res. , 1035 : 13 – 23 .
   PubMed Web of Science ®Google Scholar
• Garcia-Segura , L. M. 2008 . Aromatase in the brain: Not just for reproduction anymore . J. Neuroendocrinol. , 20 : 705 – 12 .
   PubMed Web of Science ®Google Scholar
• García-Segura , L. M. , Wozniak , A. , Azcoitia , I. , Rodriguez , J. R. , Hutchison , R. E. and Hutchison , J. B. 1999 . Aromatase expression by astrocytes after brain injury: Implications for local estrogen formation in brain repair . Neuroscience , 89 : 567 – 78 .
   PubMed Web of Science ®Google Scholar
• Goodson , J. L. 2008 . Nonapeptides and the evolutionary patterning of sociality . Prog. Brain Res. , 170 : 3 – 15 .
   PubMed Web of Science ®Google Scholar
• Goodson , J. L. and Adkins-Regan , E. 1999 . Effect of intraseptal vasotocin and vasoactive intestinal polypeptide infusions on courtship song and aggression in the male zebra finch (Taeniopygia guttata) . J. Neuroendocrinol. , 11 : 19 – 25 .
   PubMed Web of Science ®Google Scholar
• Goodson , J. L. and Bass , A. H. 2001 . Social behavior functions and related anatomical characteristics of vasotocin/vasopressin systems in vertebrates . Brain Res. Rev. , 35 : 246 – 65 .
   PubMed Web of Science ®Google Scholar
• Goodson , J. L. , Lindberg , L. and Johnson , P. 2004 . Effects of central vasotocin and mesotocin manipulations on social behavior in male and female zebra finches . Hormones Behav. , 45 : 136 – 43 .
   PubMed Web of Science ®Google Scholar
• Gore , A. C. 2008 . Developmental programming and endocrine disruptor effects on reproductive neuroendocrine systems . Front. Neuroendocrinol. , 29 : 358 – 74 .
   PubMed Web of Science ®Google Scholar
• Gotti , S. , Martini , M. , Pradotto , M. , Viglietti-Panzica , C. and Panzica , G. C. 2009 . Rapid changes on nitrinergic system in female mouse hippocampus during the ovarian cycle . J. Chem. Neuroanat. , 38 : 117 – 23 .
   PubMed Web of Science ®Google Scholar
• Gotti , S. , Martini , M. , Viglietti-Panzica , C. , Miceli , D. and Panzica , G. C. 2010 . Effects of estrous cycle and xenoestrogens expositions on mice nitric oxide producing system . Ital. J. Anat. Embryol. , 115 : 103 – 108 .
   PubMedGoogle Scholar
• Gotti , S. , Sica , M. , Viglietti Panzica , C. and Panzica , G. C. 2005 . The distribution of nitric oxide sythase immunoreactivity in the mouse brain . Microsc. Res. Technol. , 68 : 13 – 35 .
   PubMed Web of Science ®Google Scholar
• Grassi , D. , Amorim , M. A. , Garcia-Segura , L. M. and Panzica , G. 2010 . Estrogen receptor alpha is involved in the estrogenic regulation of arginine vasopressin immunoreactivity in the supraoptic and paraventricular nuclei of ovariectomized rats . Neurosci. Lett. , 474 : 135 – 39 .
   PubMed Web of Science ®Google Scholar
• Greives , T. J. , Kriegsfeld , L. J. , Bentley , G. E. , Tsutsui , K. and Demas , G. E. 2008 . Recent advances in reproductive neuroendocrinology: A role for RFamide peptides in seasonal reproduction? . Proc. Biol. Sci. , 275 : 1943 – 51 .
   PubMed Web of Science ®Google Scholar
• Greives , T. J. , Mason , A. , Scotti , M.-A. L. , Levine , J. , Ketterson , E. D. , Kriegsfeld , L. J. and Demas , G. E. 2007 . Environmental control of kisspeptin: Implications for seasonal reproduction . Endocrinology , 148 : 1158 – 66 .
   PubMed Web of Science ®Google Scholar
• Grun , F. , Watanabe , H. , Zamanian , Z. , Maeda , L. , Arima , K. , Cubacha , R. , Gardiner , D. M. , Kanno , J. , Iguchi , T. and Blumberg , B. 2006 . Endocrine-disrupting organotin compounds are potent inducers of adipogenesis in vertebrates . Mol. Endocrinol. , 20 : 2141 – 55 .
   PubMed Web of Science ®Google Scholar
• Guillemin , R. 2005 . Hypothalamic hormones a.k.a. hypothalamic releasing factors . J. Endocrinol. , 184 : 11 – 28 .
   PubMed Web of Science ®Google Scholar
• Gulpinar , M. A. and Yegen , B. C. 2004 . The physiology of learning and memory: Role of peptides and stress . Curr. Protein Peptide Sci. , 5 : 457 – 73 .
   PubMed Web of Science ®Google Scholar
• Gyllenhammar , I. , Eriksson , H. , Soderqvist , A. , Lindberg , R. H. , Fick , J. and Berg , C. 2009 . Clotrimazole exposure modulates aromatase activity in gonads and brain during gonadal differentiation in Xenopus tropicalis frogs . Aquat. Toxicol. , 91 : 102 – 9 .
   PubMed Web of Science ®Google Scholar
• Hadeishi , Y. and Wood , R. I. 1996 . Nitric oxide synthase in mating behavior circuitry of male Syrian hamster brain . J. Neurobiol. , 30 : 480 – 92 .
   PubMedGoogle Scholar
• Halldin , K. , Axelsson , J. and Brunstrom , B. 2005 . Effects of endocrine modulators on sexual differentiation and reproductive function in male Japanese quail . Brain Res. Bull. , 65 : 211 – 18 .
   PubMed Web of Science ®Google Scholar
• Hamson , D. K. , Jones , B. A. and Watson , N. V. 2004 . Distribution of androgen receptor immunoreactivity in the brainstem of male rats . Neuroscience , 127 : 797 – 803 .
   PubMed Web of Science ®Google Scholar
• Han , T. M. and De Vries , G. J. 2003 . Organizational effects of testosterone, estradiol, and dihydrotestosterone on vasopressin mRNA expression in the bed nucleus of the stria terminalis . J. Neurobiol. , 54 : 502 – 10 .
   PubMedGoogle Scholar
• Hattori , T. and Wilczynski , W. 2009 . Comparison of arginine vasotocin immunoreactivity differences in dominant and subordinate green anole lizards . Physiol. Behav. , 96 : 104 – 7 .
   PubMed Web of Science ®Google Scholar
• Heinrichs , M. and Domes , G. 2008 . Neuropeptides and social behaviour: Effects of oxytocin and vasopressin in humans . Prog. Brain Res. , 170 : 337 – 50 .
   PubMed Web of Science ®Google Scholar
• Hill , J. W. , Xu , M. and Levine , J. E. 2002 . Revisiting the reproductive functions of neuropeptide Y . Curr. Opin. Endocrinol. Diabetes , 9 : 203 – 14 .
   Google Scholar
• Hillsman , K. D. , Sanderson , N. S. and Crews , D. 2007 . Testosterone stimulates mounting behavior and arginine vasotocin expression in the brain of both sexual and unisexual whiptail lizards . Sex. Dev. , 1 : 77 – 84 .
   PubMed Web of Science ®Google Scholar
• Howdeshell , K. L. , Hotchkiss , A. K. , Thayer , K. A. , Vandenbergh , J. G. and vom Saal , F. S. 1999 . Exposure to bisphenol A advances puberty . Nature , 401 : 763 – 64 .
   PubMed Web of Science ®Google Scholar
• Hull , E. M. and Dominguez , J. M. 2006 . Getting his act together: Roles of glutamate, nitric oxide, and dopamine in the medial preoptic area . Brain Res. , 1126 : 66 – 75 .
   PubMed Web of Science ®Google Scholar
• Hull , E. M. , Lorrain , D. S. , Du , J. , Matuszewich , L. , Lumley , L. A. , Putnam , S. K. and Moses , J. 1999 . Hormone-neurotransmitter interactions in the control of sexual behavior . Behav. Brain Res. , 105 : 105 – 16 .
   PubMed Web of Science ®Google Scholar
• Hutchinson , T. H. , Brown , R. , Brugger , K. E. , Campbell , P. M. , Holt , M. , Lange , R. , McCahon , P. , Tattersfield , L. J. and van Egmond , R. 2000 . Ecological risk assessment of endocrine disruptors . Environ. Health Perspect. , 108 : 1007 – 14 .
   PubMed Web of Science ®Google Scholar
• Kask , A. , Harro , J. , von Horsten , S. , Redrobe , J. P. , Dumont , Y. and Quirion , R. 2002 . The neurocircuitry and receptor subtypes mediating anxiolytic-like effects of neuropeptide Y . Neurosci. Biobehav. Rev. , 26 : 259 – 83 .
   PubMed Web of Science ®Google Scholar
• Kauffman , A. S. 2009 . Sexual differentiation and the Kiss1 system: Hormonal and developmental considerations . Peptides , 30 : 83 – 93 .
   PubMed Web of Science ®Google Scholar
• Kime , N. M. , Whitney , T. K. , Davis , E. S. and Marler , C. A. 2007 . Arginine vasotocin promotes calling behavior and call changes in male tungara frogs . Brain Behav. Evol. , 69 : n254 – 65 .
   PubMed Web of Science ®Google Scholar
• Kime , N. M. , Whitney , T. K. , Ryan , M. J. , Rand , A. S. and Marler , C. A. 2010 . Treatment with arginine vasotocin alters mating calls and decreases call attractiveness in male tungara frogs . Gen. Comp. Endocrinol. , 165 : 221 – 28 .
   PubMed Web of Science ®Google Scholar
• Kishida , M. , McLellan , M. , Miranda , J. A. and Callard , G. V. 2001 . Estrogen and xenoestrogens upregulate the brain aromatase isoform (P450aromB) and perturb markers of early development in zebrafish (Danio rerio) . Comp. Biochem. Physiol. B Biochem. Mol. Biol. , 129 : 261 – 68 .
   PubMed Web of Science ®Google Scholar
• Kodavanti , P. R. and Curras-Collazo , M. C. 2010 . Neuroendocrine actions of organohalogens: Thyroid hormones, arginine vasopressin, and neuroplasticity . Front. Neuroendocrinol. , 31 : 479 – 496 .
   PubMed Web of Science ®Google Scholar
• Kubo , K. , Arai , O. , Ogata , R. , Omura , M. , Hori , T. and Aou , S. 2001 . Exposure to bisphenol A during the fetal and suckling periods disrupts sexual differentiation of the locus coeruleus and of behavior in the rat . Neurosci. Lett. , 304 : 73 – 76 .
   PubMed Web of Science ®Google Scholar
• Kubo , K. , Arai , O. , Omura , M. , Watanabe , R. , Ogata , R. and Aou , S. 2003 . Low dose effects of bisphenol A on sexual differentiation of the brain and behavior in rats . Neurosci. Res. , 45 : 345 – 56 .
   PubMed Web of Science ®Google Scholar
• Kuhl , A. J. and Brouwer , M. 2006 . Antiestrogens inhibit xenoestrogen-induced brain aromatase activity but do not prevent xenoestrogen-induced feminization in Japanese medaka (Oryzias latipes) . Environ. Health Perspect. , 114 : 500 – 6 .
   PubMed Web of Science ®Google Scholar
• Landgraf , R. 2001 . Neuropeptides and anxiety-related behavior . Endocr. J. , 48 : 517 – 33 .
   PubMed Web of Science ®Google Scholar
• Le Page , Y. , Scholze , M. , Kah , O. and Pakdel , F. 2006 . Assessment of xenoestrogens using three distinct estrogen receptors and the zebrafish brain aromatase gene in a highly responsive glial cell system . Environ. Health Perspect. , 114 : 752 – 58 .
   PubMed Web of Science ®Google Scholar
• Lee , P. R. , Brady , D. L. , Shapiro , R. A. , Dorsa , D. M. and Koenig , J. I. 2005 . Social interaction deficits caused by chronic phencyclidine administration are reversed by oxytocin . Neuropsychopharmacology , 30 : 1883 – 94 .
   PubMed Web of Science ®Google Scholar
• Lee , P. R. , Brady , D. L. , Shapiro , R. A. , Dorsa , D. M. and Koenig , J. L. 2007 . Prenatal stress generates deficits in rat social behavior: Reversal by oxytocin . Brain Res. , 1156 : 152 – 67 .
   PubMed Web of Science ®Google Scholar
• Lee , Y. M. , Seo , J. S. , Kim , I. C. , Yoon , Y. D. and Lee , J. S. 2006 . Endocrine disrupting chemicals (bisphenol A, 4-nonylphenol, 4-tert-octylphenol) modulate expression of two distinct cytochrome P450 aromatase genes differently in gender types of the hermaphroditic fish Rivulus marmoratus . Biochem. Biophy., Res. Commun. , 345 : 894 – 903 .
   PubMed Web of Science ®Google Scholar
• Lephart , E. D. , Adlercreutz , H. and Lund , T. D. 2001 . Dietary soy phytoestrogen effects on brain structure and aromatase in Long-Evans rats . Neuroreport , 12 : 3451 – 55 .
   PubMed Web of Science ®Google Scholar
• Lin , F. , Wu , J. , Abdelnabi , M. A. , Ottinger , M. A. and Giusti , M. M. 2004 . Effects of dose and glycosylation on the transfer of genistein into the eggs of the Japanese quail (Coturnix japonica) . J. Agric. Food Chem. , 52 : 2397 – 403 .
   PubMed Web of Science ®Google Scholar
• Luque , J. M. , Deblas , M. R. , Segovia , S. and Guillamon , A. 1992 . Sexual dimorphism of the dopamine-beta-hydroxylase-immunoreactive neurons in the rat locus ceruleus . Dev. Brain Res. , 67 : 211 – 15 .
   PubMedGoogle Scholar
• Lyssimachou , A. , Jenssen , B. M. and Arukwe , A. 2006 . Brain cytochrome P450 aromatase gene isoforms and activity levels in atlantic salmon after waterborne exposure to nominal environmental concentrations of the pharmaceutical ethynylestradiol and antifoulant tributyltin . Toxicol. Sci. , 91 : 82 – 92 .
   PubMed Web of Science ®Google Scholar
• Magni , P. , Dozio , E. , Ruscica , M. , Celotti , F. , Masini , M. A. , Prato , P. , Broccoli , M. , Mambro , A. , More , M. and Strollo , F. 2009 . Feeding behavior in mammals including humans . Ann. NY Acad. Sci. , 1163 : 221 – 32 .
   PubMed Web of Science ®Google Scholar
• Martini , M. , Di Sante , G. , Collado , P. , Pinos , H. , Guillamon , A. and Panzica , G. C. 2008 . Androgen receptors are required for full masculinization of nitric oxide synthase system in rat limbic-hypothalamic region . Hormones Behav. , 54 : 557 – 64 .
   PubMed Web of Science ®Google Scholar
• Martini , M. , Miceli , D. , Gotti , S. , Viglietti-Panzica , C. , Fissore , E. , Palanza , P. and Panzica , G. C. 2010 . Effects of perinatal administration of bisphenol A on the neuronal nitric oxide synthase expressing system in the hypothalamus and limbic system of CD1 mice . J. Neuroendocrinol. , 22 : 1004 – 12 .
   PubMed Web of Science ®Google Scholar
• Martini , M. , Pradotto , M. , Viglietti-Panzica , C. and Panzica , G. C. 2009 . Synergic effects of estradiol and progesterone on regulation of the hypothalamic neuronal nitric oxide synthase expression in ovariectomized mice . Trab. Instit. Cajal , 82 : 250
   Google Scholar
• Mattsson , A. , Mura , E. , Brunstrom , B. , Panzica , G. and Halldin , K. 2008 . Selective activation of estrogen receptor alpha in Japanese quail embryos affects reproductive organ differentiation but not the male sexual behavior or the parvocellular vasotocin system . Gen. Comp. Endocrinol. , 159 : 150 – 57 .
   PubMed Web of Science ®Google Scholar
• McCarthy , M. M. , Wright , C. L. and Schwarz , J. M. 2009 . New tricks by an old dogma: mechanisms of the organizational/activational hypothesis of steroid-mediated sexual differentiation of brain and behavior . Hormones Behav. , 55 : 655 – 65 .
   PubMed Web of Science ®Google Scholar
• McEwen , B. S. 1987 . Steroid hormones and brain development: Some guidelines for understanding actions of pseudohormones and other toxic agents . Environ. Health Perspect. , 74 : 177 – 84 .
   PubMed Web of Science ®Google Scholar
• Miceli , D. , Martini , M. , Franceschini , I. , Palanza , P. and Panzica , G. C. Organizational effects of bisphenol-A on kisspeptin expression in the hypothalamus of CD1 mouse . Paper read at 1st World Conference on Kisspeptin, at Cordoba . October 2008 , Spain.
   Google Scholar
• Miceli , D. , Silvestrini , V. , Viglietti-Panzica , C. , Palanza , P. and Panzica , G. C. Early exposure to bisphenol A induces alterations of Locus Coeruleus volume in CD1 mice . 7th Int. Congr. Neuroendocrinology (Rouen) Abstracts . pp. P2 – 179 .
   Google Scholar
• Milligan , S. R. , Khan , O. and Nash , M. 1998 . Competitive binding of xenobiotic oestrogens to rat alpha-fetoprotein and to sex steroid binding proteins in human and rainbow trout (Oncorhynchus mykiss) plasma . Gen. Comp. Endocrinol. , 112 : 89 – 95 .
   PubMed Web of Science ®Google Scholar
• Moore , F. L. and Lowry , C. A. 1998 . “ Comparative neuroanatomy of vasotocin and vasopressin in the vertebrate brain ” . In Comparative neuroendocrinology of vertebrate reproduction and growth: Organismal, cellular and molecular aspects Edited by: Trudeau , V. L. Vol. 119(C) , 251 – 60 . Comp. Biochem. Physiol
   Google Scholar
• Mosconi , G. , Carnevali , O. , Franzoni , M. F. , Cottone , E. , Lutz , I. , Kloas , W. , Yamamoto , K. , Kikuyama , S. and Polzonetti-Magni , A. M. 2002 . Environmental estrogens and reproductive biology in amphibians . Gen. Comp. Endocrinol. , 126 : 125 – 29 .
   PubMed Web of Science ®Google Scholar
• Mura , E. , Barale , C. , Quinn , M. J. Jr. , Panzica , G. C. , Ottinger , M. A. and Viglietti Panzica , C. 2009 . Organizational effects of DDE on brain vasotocin system in male Japanese quail . Neurotoxicology , 30 : 479 – 84 .
   PubMed Web of Science ®Google Scholar
• Naftolin , F. 1994 . Brain aromatization of androgens . J. Reprod. Med. , 39 : 257 – 61 .
   PubMed Web of Science ®Google Scholar
• Naftolin , F. , Horvath , T. L. and Balthazart , J. 2001 . Estrogen synthetase (aromatase) immunohistochemistry reveals concordance between avian and rodent limbic systems and hypothalami . Exp. Biol. Med. , 226 : 717 – 25 .
   Web of Science ®Google Scholar
• Navarro , V. M. , Sanchez-Garrido , M. A. , Castellano , J. M. , Roa , J. , Garcia-Galiano , D. , Pineda , R. , Aguilar , E. , Pinilla , L. and Tena-Sempere , M. 2009 . Persistent impairment of hypothalamic KiSS-1 system after exposures to estrogenic compounds at critical periods of brain sex differentiation . Endocrinology , 150 : 2359 – 67 .
   PubMed Web of Science ®Google Scholar
• Nelson , R. J. , Trainor , B. C. , Chiavegatto , S. and Demas , G. E. 2006 . Pleiotropic contributions of nitric oxide to aggressive behavior . Neurosci. Biobehav. Rev. , 30 : 346 – 55 .
   PubMed Web of Science ®Google Scholar
• Nelson , R. J. , Kriegsfeld , L. J. , Dawson , V. L. and Dawson , T. M. 1997 . Effects of nitric oxide on neuroendocrine function and behavior . Front. Neuroendocrinol. , 18 : 463 – 91 .
   PubMed Web of Science ®Google Scholar
• Newbold , R. R. , Padilla-Banks , E. , Jefferson , W. N. and Heindel , J. J. 2008 . Effects of endocrine disruptors on obesity . Int. J. Androl. , 31 : 201 – 8 .
   PubMed Web of Science ®Google Scholar
• Oberto , A. , Tolosano , E. , Brusa , R. , Altruda , F. , Panzica , G. and Eva , C. 1998 . The murine Y1 receptor 5' upstream sequence directs cell-specific and developmentally regulated LacZ expression in transgenic mice CNS . Eur. J. Neurosci. , 10 : 3257 – 68 .
   PubMed Web of Science ®Google Scholar
• Ottinger , M. A. , Lavoie , E. T. , Thompson , N. , Bohannon , M. , Dean , K. and Quinn , M. J. Jr. 2009 . Is the gonadotropin releasing hormone system vulnerable to endocrine disruption in birds? . Gen. Comp. Endocrinol. , 163 : 104 – 8 .
   PubMed Web of Science ®Google Scholar
• Ottinger , M. A. , Lavoie , E. , Thompson , N. , Barton , A. , Whitehouse , K. , Abdelnabi , M. , Quinn , M. J. Jr. , Panzica , G. C. and Viglietti-Panzica , C. 2008 . Neuroendocrine and behavioral effects of embryonic exposure to endocrine disrupting chemicals in birds . Brain Res. Rev. , 57 : 376 – 85 .
   PubMedGoogle Scholar
• Panzica , G. C. , Arevalo , R. , Sanchez , F. , Alonso , J. R. , Aste , N. , Viglietti-Panzica , C. , Aijon , J. and Vazquez , R. 1994 . Topographical distribution of reduced nicotinamide adenine dinucleotide phosphate-diaphorase in the brain of the Japanese quail . J. Comp. Neurol. , 342 : 97 – 114 .
   PubMed Web of Science ®Google Scholar
• Panzica , G. C. , Aste , N. , Castagna , C. , Viglietti-Panzica , C. and Balthazart , J. 2001 . Steroid-induced plasticity in the sexually dimorphic vasotocinergic innervation of the avian brain: Behavioral implications . Brain Res. Rev. , 37 : 178 – 200 .
   PubMedGoogle Scholar
• Panzica , G. C. , Viglietti-Panzica , C. and Balthazart , J. 1996 . The sexually dimorphic medial preoptic nucleus of quail: A key brain area mediating steroid action on male sexual behavior . Front. Neuroendocrinol. , 17 : 51 – 125 .
   PubMed Web of Science ®Google Scholar
• Panzica , G. C. , Viglietti-Panzica , C. , Sica , M. , Gotti , S. , Martini , M. , Pinos , H. , Carrillo , B. and Collado , P. 2006 . Effects of gonadal hormones on central nitric oxide producing systems . Neuroscience , 138 : 987 – 95 .
   PubMed Web of Science ®Google Scholar
• Panzica , G. C. , Balthazart , J. , Pessatti , M. and Viglietti-Panzica , C. 2002 . The parvocellular vasotocin system of Japanese quail: a developmental and adult model for the study of influences of gonadal hormones on sexually differentiated and behaviorally relevant neural circuits . Environ. Health Perspect. , 110 ( suppl. 3 ) : 423 – 28 .
   PubMed Web of Science ®Google Scholar
• Panzica , G. C. , Castagna , C. , Viglietti-Panzica , C. , Russo , C. , Tlemçani , O. and Balthazart , J. 1998 . Organizational effects of estrogens on brain vasotocin and sexual behavior in quail . J. Neurobiol , 37 : 684 – 99 .
   PubMedGoogle Scholar
• Panzica , G. C. , Mura , E. , Miceli , D. , Martini , M. , Gotti , S. and Viglietti Panzica , C. 2009 . “ Effects of xenoestrogens on the differentiation of behaviorally-relevant neural circuits in higher vertebrates ” . In Trends in comparative endocrinology and neurobiology , Edited by: Vaudry , H. , Rubois , E. , Coast , G. M. and Vallarino , M. 271 – 278 . New York : New York Academy of Sciences .
   Google Scholar
• Panzica , G. C. , Viglietti Panzica , C. and Ottinger , M. A. 2005 . Introduction: Neurobiological impact of environmental estrogens . Brain Res. Bull. , 65 : 187 – 91 .
   PubMed Web of Science ®Google Scholar
• Panzica , G. C. , Viglietti-Panzica , C. , Mura , E. , Quinn , M. J. Jr. , Palanza , P. and Ottinger , M. A. 2007 . Effects of xenoestrogens on the differentiation of behaviorally relevant neural circuits . Front. Neuroendocrinol. , 28 : 179 – 200 .
   PubMed Web of Science ®Google Scholar
• Parhar , I. S. , Tosaki , H. , Sakuma , Y. and Kobayashi , M. 2001 . Sex differences in the brain of goldfish: Gonadotropin-releasing hormone and vasotocinergic neurons . Neuroscience , 104 : 1099 – 110 .
   PubMed Web of Science ®Google Scholar
• Patisaul , H. B. , Todd , K. L. , Mickens , J. A. and Adewale , H. B. 2009 . Impact of neonatal exposure to the ERalpha agonist PPT, bisphenol-A or phytoestrogens on hypothalamic kisspeptin fiber density in male and female rats . Neurotoxicology , 30 : 350 – 57 .
   PubMed Web of Science ®Google Scholar
• Patisaul , H. B. , Fortino , A. E. and Polston , E. K. 2006 . Neonatal genistein or bisphenol-A expose alters sexual differentiation of the AVPV . Neurotoxicol. Teratol. , 28 : 111 – 18 .
   PubMed Web of Science ®Google Scholar
• Pelissero , C. , Lenczowski , M. J. , Chinzi , D. , Davail-Cuisset , B. , Sumpter , J. P. and Fostier , A. 1996 . Effects of flavonoids on aromatase activity, an in vitro study . J. Steroid Biochem. Mol. Biol. , 57 : 215 – 23 .
   PubMed Web of Science ®Google Scholar
• Peterson , R. S. , Saldanha , C. J. and Schlinger , B. A. 2001 . Rapid upregulation of aromatase mRNA and protein following neural injury in the zebra finch (Taeniopygia guttata) . J. Neuroendocrinol. , : 13317 – 23 .
   Web of Science ®Google Scholar
• Pierman , S. , Sica , M. , Allieri , F. , Viglietti-Panzica , C. , Panzica , G. C. and Bakker , J. 2008 . Activational effects of estradiol and dihydrotestosterone on social recognition and the arginine-vasopressin immunoreactive system in male mice lacking a functional aromatase gene . Hormones Behav. , 54 : 98 – 106 .
   PubMed Web of Science ®Google Scholar
• Plumari , L. , Viglietti Panzica , C. , Allieri , F. , Honda , S. , Harada , N. , Absil , P. , Balthazar , J. and Panzica , G. C. 2002 . Changes in the arginine-vasopressin immunoreactive systems in male mice lacking a functional aromatase gene . J. Neuroendocrinol. , 14 : 971 – 78 .
   PubMed Web of Science ®Google Scholar
• Ponzi , D. , Palanza , P. , Maruniak , J. A. , Parmigiani , S. and Vom Saal , F. S. Sexual dimorphism in the number of TH-immunostained neurons in the locus coeruleus of young mice is eliminated by prenatal exposure to bisphenol A . 5th Forum of European Neuroscience Abstract A008.21 .
   Google Scholar
• Popik , P. and Van Ree , J. M. 1998 . Neurohypophyseal peptides and social recognition in rats . Prog. Brain Res. , 119 : 415 – 36 .
   PubMed Web of Science ®Google Scholar
• Roa , J. , Aguilar , E. , Dieguez , C. , Pinilla , L. and Tena-Sempere , M. 2008 . New frontiers in kisspeptin/GPR54 physiology as fundamental gatekeepers of reproductive function . Front. Neuroendocrinol. , 29 : 48 – 69 .
   PubMed Web of Science ®Google Scholar
• Roselli , C. E. , Liu , M. and Hurn , P. D. 2009 . Brain aromatization: Classic roles and new perspectives . Semin. Reprod. Med. , 27 : 207 – 17 .
   PubMed Web of Science ®Google Scholar
• Roselli , C. E. , Abdelgadir , S. E. and Resko , J. A. 1997 . “ Regulation of aromatase gene expression in the adult rat brain ” . In Hormones, brain, and behavior Edited by: Panzica , G. C. and Balthazart , J. Vol. 44 , 351 – 57 . Brain Res. Bull
   Google Scholar
• Roy , B. N. , Reid , R. L. and Van Vug , D. A. 1999 . The effects of estrogen and progesterone on corticotropin-releasing hormone and arginine vasopressin messenger ribonucleic acid levels in the paraventricular nucleus and supraoptic nucleus of the rhesus monkey . Endocrinology , 140 : 2191 – 98 .
   PubMed Web of Science ®Google Scholar
• Rubin , B. S. , Lenkowski , J. R. , Schaeberle , C. M. , Vandenberg , L. N. , Ronsheim , P. M. and Soto , A. M. 2006 . Evidence of altered brain sexual differentiation in mice exposed perinatally to low, environmentally relevant levels of bisphenol A . Endocrinology , 147 : 3681 – 91 .
   PubMed Web of Science ®Google Scholar
• Rubin , B. S. , Murray , M. K. , Damassa , D. A. , King , J. C. and Soto , A. M. 2001 . Perinatal exposure to low doses of bisphenol-A affects body weight, patterns of estrous cyclicity and plasma LH levels . Environ. Health Perspect. , 109 : 675 – 80 .
   PubMed Web of Science ®Google Scholar
• Ruhlen , R. L. , Howdeshell , K. L. , Mao , J. , Taylor , J. A. , Bronson , F. H. , Newbold , R. R. , Welshons , W. V. and vom Saal , F. S. 2008 . Low phytoestrogen levels in feed increase fetal serum estradiol resulting in the “fetal estrogenization syndrome” and obesity in CD-1 mice . Environ. Health Perspect. , 116 : 322 – 28 .
   PubMed Web of Science ®Google Scholar
• Sakimura , M. , Tsukada , A. , Usami , M. , Hanzawa , S. , Saito , N. , Ohno , Y. and Shimada , K. 2002 . Effect of estradiol and nonylphenol on mRNA expression of estrogen receptors α and β, and cytochrome P450 aromatase in the gonad of chicken embryos . J. Poult. Sci. , 39 : 302 – 9 .
   Google Scholar
• Saldanha , C. J. , Duncan , K. A. and Walters , B. J. 2009 . Neuroprotective actions of brain aromatase . Front. Neuroendocrinol. , 30 : 106 – 18 .
   PubMed Web of Science ®Google Scholar
• Scallet , A. C. , Wofford , M. , Meredith , J. C. , Allaben , W. T. and Ferguson , S. A. 2003 . Dietary exposure to genistein increases vasopressin but does not alter beta-endorphin in the rat hypothalamus . Toxicol. Sci. , 72 : 296 – 300 .
   PubMed Web of Science ®Google Scholar
• Scholz , B. , Alm , H. , Mattsson , A. , Nilsson , A. , Kultima , K. , Savitski , M. M. , Falth , M. , Skold , K. , Brunstrom , B. , Andren , P. E. and Dencker , L. 2010 . Neuropeptidomic analysis of the embryonic Japanese quail diencephalon . BMC Dev. Biol. , 10 : 30
   PubMed Web of Science ®Google Scholar
• Scordalakes , E. M. and Rissman , E. F. 2004 . Aggression and arginine vasopressin immunoreactivity regulation by androgen receptor and estrogen receptor alpha . Genes Brain Behav. , 3 : 20 – 26 .
   PubMed Web of Science ®Google Scholar
• Sica , M. , Martini , M. , Verzè , L. , Viglietti-Panzica , C. and Panzica , G. C. 2007 . Expression of nitric oxide synthase in the male mouse limbic system is mediated by estrogen receptors . Trab. Inst. Cajal LXXXI , : 47 – 48 .
   Google Scholar
• Sica , M. , Martini , M. , Viglietti-Panzica , C. and Panzica , G. C. 2009 . Estrous cycle influences the expression of neuronal nitric oxide synthase in the hypothalamus and limbic system of female mice . BMC Neurosci. , 10 ( 78 ) : 01 – 14 .
   PubMed Web of Science ®Google Scholar
• Sica , M. , Plumari , L. , Honda , S. , Harada , N. , Absil , P. , Viglietti Panzica , C. , Balthazart , J. and Panzica , G. C. 2002 . Changes in the neuronal nitric oxide synthase immunoreactive system in male mice lacking a functional aromatase gene . Hormones Behav. , 41 : 490
   Google Scholar
• Simerly , R. B. , Swanson , L. W. and Gorski , R. A. 1985 . The distribution of monoaminergic cells and fibers in a periventricular preoptic nucleus involved in the control of gonadotropin release: Immunohistochemical evidence for a dopaminergic sexual dimorphism . Brain Res. , 330 : 55 – 64 .
   PubMed Web of Science ®Google Scholar
• Simerly , R. B. , Swanson , L. W. , Handa , R. J. and Gorski , R. A. 1985 . Influence of perinatal androgen on the sexually dimorphic distribution of tyrosine hydroxylase-immunoreactive cells and fibers in the anteroventral periventricular nucleus of the rat . Neuroendocrinology , 40 : 501 – 10 .
   PubMed Web of Science ®Google Scholar
• Simpson , E. R. , Clyne , C. , Rubin , G. , Boon , W. C. , Robertson , K. , Britt , K. , Speed , C. and Jones , M. 2002 . Aromatase—A brief overview . Annu. Rev. Physiol. , 64 : 93 – 127 .
   PubMed Web of Science ®Google Scholar
• Skuse , D. H. and Gallagher , L. 2009 . Dopaminergic-neuropeptide interactions in the social brain . Trends Cogn. Sci. , 13 : 27 – 35 .
   PubMed Web of Science ®Google Scholar
• Smith , J. T. , Clifton , D. K. and Steiner , R. A. 2006 . Regulation of the neuroendocrine reproductive axis by kisspeptin-GPR54 signaling . Reproduction , 131 : 623 – 30 .
   PubMed Web of Science ®Google Scholar
• Snyder , S. H. , Jaffrey , S. R. and Zakhary , R. 1998 . Nitric oxide and carbon monoxide: Parallel roles as neural messengers . Brain Res. Rev. , 26 : 167 – 75 .
   PubMedGoogle Scholar
• Stanley , B. G. , Kyrkpouli , S. E. , Lampert , S. and Leibowitz , S. F. 1986 . Neuropeptide Y injected into the hypothalamus: A powerful neurochemical inducer of hyperphagia and obesity . Peptides , 7 : 1189 – 92 .
   PubMed Web of Science ®Google Scholar
• Stoker , T. E. , Cooper , R. L. , Lambright , C. S. , Wilson , V. S. , Furr , J. and Gray , L. E. 2005 . In vivo and in vitro anti-androgenic effects of DE-71, a commercial polybrominated diphenyl ether (PBDE) mixture . Toxicol. Appl. Pharmacol. , 207 : 78 – 88 .
   PubMed Web of Science ®Google Scholar
• Sumpter , J. P. 1998 . Xenoendocrine disrupters: Environmental impacts . Toxicol. Lett. , 102–3 : 337 – 42 .
   Google Scholar
• Tena-Sempere , M. 2010 . Kisspeptin signaling in the brain: Recent developments and future challenges . Mol. Cell. Endocrinol. , 314 : 164 – 69 .
   PubMed Web of Science ®Google Scholar
• Tena-Sempere , M. 2010 . Kisspeptin/GPR54 system as potential target for endocrine disruption of reproductive development and function . Int. J. Androl. , 33 : 360 – 68 .
   PubMed Web of Science ®Google Scholar
• Thompson , R. R. , Walton , J. C. , Bhalla , R. , George , K. C. and Beth , E. H. 2008 . A primitive social circuit: Vasotocin–substance P interactions modulate social behavior through a peripheral feedback mechanism in goldfish . Eur. J. Neurosci. , 27 : 2285 – 93 .
   PubMed Web of Science ®Google Scholar
• Urano , A. , Hyodo , S. and Suzuki , M. 1992 . Molecular evolution of neurohypophysial hormone precursors . Prog. Brain Res. , 92 : 39 – 46 .
   PubMed Web of Science ®Google Scholar
• Urbatzka , R. , Lutz , I. , Opitz , R. and Kloas , W. 2006 . Luteinizing hormone, follicle stimulating hormone, and gonadotropin releasing hormone mRNA expression of Xenopus laevis in response to endocrine disrupting compounds affecting reproductive biology . Gen. Comp. Endocrinol. , 146 : 119 – 25 .
   PubMed Web of Science ®Google Scholar
• Valassi , E. , Scacchi , M. and Cavagnini , F. 2008 . Neuroendocrine control of food intake . Nutr. Metab. Cardiovasc. Dis. , 18 : 158 – 68 .
   PubMed Web of Science ®Google Scholar
• Veenema , A. H. and Neumann , I. D. 2008 . Central vasopressin and oxytocin release: Regulation of complex social behaviours . Prog. Brain Res. , 170 : 261 – 76 .
   PubMed Web of Science ®Google Scholar
• Viglietti-Panzica , C. , Anselmetti , G. C. , Balthazart , J. , Aste , N. and Panzica , G. C. 1992 . Vasotocinergic innervation of the septal region in the Japanese quail: Sexual differences and the influence of testosterone . Cell Tissue Res. , 267 : 261 – 65 .
   Web of Science ®Google Scholar
• Viglietti-Panzica , C. , Aste , N. , Balthazart , J. and Panzica , G. C. 1994 . Vasotocinergic innervation of sexually dimorphic medial preoptic nucleus of the male Japanese quail: influence of testosterone . Brain Res. , 657 : 171 – 84 .
   PubMed Web of Science ®Google Scholar
• Viglietti-Panzica , C. , Montoncello , B. , Mura , E. , Pessatti , M. and Panzica , G. C. 2005 . Organizational effects of diethylstilbestrol on brain vasotocin and sexual behavior in male quail . Brain Res. Bull. , 65 : 225 – 33 .
   PubMed Web of Science ®Google Scholar
• Viglietti-Panzica , C. , Mura , E. and Panzica , G. C. 2007 . Effects of early embryonic exposure to genistein on male copulatory behavior and vasotocin system of Japanese quail . Hormones Behav. , 51 : 355 – 63 .
   PubMed Web of Science ®Google Scholar
• Vincent , S. R. 2010 . Nitric oxide neurons and neurotransmission . Prog. Neurobiol. , 90 : 246 – 55 .
   PubMed Web of Science ®Google Scholar
• Vincent , S. R. and Kimura , H. 1992 . Histochemical mapping of nitric oxide synthase in the rat brain . Neuroscience , 46 : 755 – 84 .
   PubMed Web of Science ®Google Scholar
• vom Saal , F. S. and Welshons , W. V. 2006 . Large effects from small exposures. II. The importance of positive controls in low-dose research on bisphenol A . Environ. Res. , 100 : 50 – 76 .
   PubMed Web of Science ®Google Scholar
• Wallen , K. 2009 . The organizational hypothesis: Reflections on the 50th anniversary of the publication of Phoenix, Goy, Gerall, and Young (1959) . Hormones Behav. , 55 : 561 – 65 .
   PubMed Web of Science ®Google Scholar
• Weber , K. S. , Setchell , K. D. R. and Lephart , E. D. 2001 . Maternal and perinatal brain aromatase: Effects of dietary soy phytoestrogens . Dev. Brain Res. , 126 : 217 – 21 .
   PubMedGoogle Scholar
• Welshons , W. V. , Nagel , S. C. and vom Saal , F. S. 2006 . Large effects from small exposures. III. Endocrine mechanisms mediating effects of bisphenol A at levels of human exposure . Endocrinology , 147 ( 6 suppl ) : S56 – 69 .
   PubMed Web of Science ®Google Scholar
• Welshons , W. V. , Thayer , K. A. , Judy , B. M. , Taylor , J. A. , Curran , E. M. and vom Saal , F. S. 2003 . Large effects from small exposures. I. Mechanisms for endocrine-disrupting chemicals with estrogenic activity . Environ. Health Perspect. , 111 : 994 – 1006 .
   PubMed Web of Science ®Google Scholar
• Wilson , J. Y. , McArthur , A. G. and Stegeman , J. J. 2005 . Characterization of a cetacean aromatase (CYP19) and the phylogeny and functional conservation of vertebrate aromatase . Gen. Comp. Endocrinol. , 140 : 74 – 3 .
   PubMed Web of Science ®Google Scholar
• Ye , L. and Leung , L. K. 2008 . Effect of dioxin exposure on aromatase expression in ovariectomized rats . Toxicol. Appl. Pharmacol. , 229 : 102 – 8 .
   PubMed Web of Science ®Google Scholar
• Young , L. J. and Wang , Z. 2004 . The neurobiology of pair bonding . Nature Neurosci. , 7 : 1048 – 54 .
   PubMed Web of Science ®Google Scholar
• Young , L. J. , Wang , Z. and Insel , T. R. 1998 . Neuroendocrine bases of monogamy . Trends Neurosci. , 21 : 71 – 75 .
   PubMed Web of Science ®Google Scholar
• Zhao , C. , Fujinaga , R. , Yanai , A. , Kokubu , K. , Takeshita , Y. , Watanabe , Y. and Shinoda , K. 2008 . Sex-steroidal regulation of aromatase mRNA expression in adult male rat brain: A quantitative non-radioactive in situ hybridization study . Cell Tissue Res. , 332 : 381 – 91 .
   PubMed Web of Science ®Google Scholar