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Original Articles

Respiratory Health Effects of Large Animal Farming Environments

, &
Pages 524-541 | Published online: 30 Nov 2012

REFERENCES

  • American Thoracic Society . 1998 . Respiratory health hazards in agriculture . Am. J. Respir. Crit. Care Med. , 158 : S1 – S76 .
  • Akira , S. , Uematsu , S. and Takeuchi , O. 2006 . Pathogen recognition and innate immunity . Cell , 124 : 783 – 801 .
  • Alexis , N. E. , Lay , J. C. , Zeman , K. , Bennett , W. E. , Peden , D. B. , Soukup , J. M. , Devlin , R. B. and Becker , S. 2006 . Biological material on inhaled coarse fraction particulate matter activates airway phagocytes in vivo in healthy volunteers . J. Allergy Clin. Immunol. , 117 : 1396 – 1403 .
  • Bailey , K. L. , Poole , J. A. , Mathisen , T. L. , Wyatt , T. A. , Von Essen , S. G. and Romberger , D. J. 2008 . Toll-like receptor 2 is upregulated by hog confinement dust in an IL-6-dependent manner in the airway epithelium . Am. J. Physiol. Lung Cell Mol. Physiol. , 294 : L1049 – L1054 .
  • Becker , S. , Fenton , M. J. and Soukup , J. M. 2002 . Involvement of microbial components and toll-like receptors 2 and 4 in cytokine responses to air pollution particles. Am. J. Respir. Cell Mol. Biol. , 27 : 611 – 618 .
  • Becker , S. , Soukup , J. M. , Sioutas , C. and Cassee , F. R. 2003 . Response of human alveolar macrophages to ultrafine, fine, and coarse urban air pollution particles. Exp. Lung Res. , 29 : 29 – 44 .
  • Braun-Fahrlander , C. 2003 . Environmental exposure to endotoxin and other microbial products and the decreased risk of childhood atopy: Evaluating developments since April 2002 . Curr. Opin. Allergy Clin. Immunol. , 3 : 325 – 329 .
  • Braun-Fahrlander , C. , Gassner , M. , Grize , L. , Neu , U. , Sennhauser , F. H. , Varonier , H. S. , Vuille , J. C. and Wuthrich , B. 1999 . Prevalence of hay fever and allergic sensitization in farmer's children and their peers living in the same rural community. SCARPOL team. Swiss study on childhood allergy and respiratory symptoms with respect to air pollution . Clin. Exp. Allergy , 29 : 28 – 34 .
  • Burch , J. B. , Svendsen , E. , Siegel , P. D. , Wagner , S. E. , Von Essen , S. , Keefe , T. , Mehaffy , J. , Martinez , A. S. , Bradford , M. , Baker , L. , Cranmer , B. , Saito , R. , Tessari , J. , Linda , P. , Andersen , C. , Christensen , O. , Koehncke , N. and Reynolds , S. J. 2010 . Endotoxin exposure and inflammation markers among agricultural workers in Colorado and Nebraska . J. Toxicol. Environ. Health A , 73 : 5 – 22 .
  • Centers for Disease Control. 1993. Fatalities attributed to entering manure waste pits—Minnesota, 1992. Morbid. Mortal. Weekly Rep. 42(17): 325–329. http://www.cdc.gov/mmwr/preview/mmwrhtml/00020468.htm (http://www.cdc.gov/mmwr/preview/mmwrhtml/00020468.htm)
  • Charavaryamath , C. , Juneau , V. , Suri , S. S. , Janardhan , K. S. , Townsend , H. and Singh , B. 2008 . Role of toll-like receptor 4 in lung inflammation following exposure to swine barn air . Exp. Lung Res. , 34 : 19 – 35 .
  • Chen , Y. , Rennie , D. , Cormier , Y. , McDuffie , H. , Pahwa , P. and Dosman , J. 2007 . Reduced risk of atopic sensitization among farmers: The Humboldt study . Int. Arch. Allergy Immunol. , 144 : 338 – 342 .
  • Cleave , J. , Willson , P. J. , Town , J. and Gordon , J. R. 2010 . Fractionation of swine barn dust and assessment of its impact on the respiratory tract following repeated airway exposure . J. Toxicol. Environ. Health A , 73 : 1090 – 1101 .
  • Cormier , Y. , Duchaine , C. , Israel-Assayag , E. , Bedard , G. , Laviolette , M. and Dosman , J. 1997 . Effects of repeated swine building exposures on normal naive subjects . Eur. Respir. J. , 10 : 1516 – 1522 .
  • Donham , K. J. , Reynolds , S. J. , Whitten , P. , Merchant , J. A. , Burmeister , L. and Popendorf , W. J. 1995 . Respiratory dysfunction in swine production facility workers: Dose-response relationships of environmental exposures and pulmonary function . Am. J. Ind. Med. , 27 : 405 – 418 .
  • Dosman , J. A. , Lawson , J. A. , Kirychuk , S. P. , Cormier , Y. , Biem , J. and Koehncke , N. 2006 . Three new cases of apparent occupational asthma in swine confinement facility employees . Eur. Respir. J. , 28 : 1281 – 1282 .
  • Dosman , J. A. , Lawson , J. A. , Kirychuk , S. P. , Cormier , Y. , Biem , J. and Koehncke , N. 2004 . Occupational asthma in newly employed workers in intensive swine confinement facilities . Eur. Respir. J. , 24 : 698 – 702 .
  • Dosman , J. A. , Senthilselvan , A. , Kirychuk , S. P. , Lemay , S. , Barber , E. M. , Willson , P. , Cormier , Y. and Hurst , T. S. 2000 . Positive human health effects of wearing a respirator in a swine barn . Chest , 118 : 852 – 860 .
  • Eder , W. , Klimecki , W. , Yu , L. , von Mutius , E. , Riedler , J. , Braun-Fahrlander , C. , Nowak , D. and Martinez , F. D. 2004 . ALEX Study Team . Toll-like receptor 2 as a major gene for asthma in children of European farmers. J. Allergy Clin. Immunol. , 113 : 482 – 488 .
  • Eder , W. , Klimecki , W. , Yu , L. , von Mutius , E. , Riedler , J. , Braun-Fahrlander , C. , Nowak , D. , Holst , O. , Martinez , F. D. and Team , ALEX . 2006 . Association between exposure to farming, allergies and genetic variation in CARD4/NOD1 . Allergy , 61 : 1117 – 1124 .
  • Eduard , W. , Douwes , J. , Omenaas , E. and Heederik , D. 2004 . Do farming exposures cause or prevent asthma? Results from a study of adult Norwegian farmers . Thorax , 59 : 381 – 386 .
  • Eduard , W. , Pearce , N. and Douwes , J. 2009 . Chronic bronchitis, COPD, and lung function in farmers: The role of biological agents . Chest , 136 : 716 – 725 .
  • Ege , M. J. , Mayer , M. , Normand , A. C. , Genuneit , J. , Cookson , W. O. , Braun-Fahrlander , C. , Heederik , D. , Piarroux , R. and von Mutius , E. 2011 . GABRIELA Transregio 22 Study Group . Exposure to environmental microorganisms and childhood asthma. N. Engl. J. Med. , 364 : 701 – 709 .
  • Ek , A. , Palmberg , L. , Sundblad , B. M. and Larsson , K. 2005 . Salmeterol does not alter increased bronchial responsiveness caused by organic dust exposure . Chest , 128 : 3038 – 3047 .
  • Ernst , P. and Cormier , Y. 2000 . Relative scarcity of asthma and atopy among rural adolescents raised on a farm . Am. J. Respir. Crit. Care Med. , 161 : 1563 – 1566 .
  • Farthing , P. , Rennie , D. , Pahwa , P. , Janzen , B. and Dosman , J. 2009 . The association between farming activities and respiratory health in rural school age children . J. Agromed. , 14 : 256 – 262 .
  • Ghio , A. J. , Carraway , M. S. and Madden , M. C. 2012 . Composition of air pollution particles and oxidative stress in cells, tissues, and living systems . J. Toxicol. Environ. Health B , 15 : 1 – 21 .
  • Girard , M. and Cormier , Y. 2010 . Hypersensitivity pneumonitis . Curr. Opin. Allergy Clin. Immunol. , 10 : 99 – 103 .
  • Hiel , D. , von Scheele , I. , Sundblad , B. M. , Larsson , K. and Palmberg , L. 2009 . Evaluation of respiratory effects related to high-pressure cleaning in a piggery with and without robot pre-cleaning . Scand. J. Work Environ. Health , 35 : 376 – 383 .
  • Israel-Assayag , E. and Cormier , Y. 2002 . Adaptation to organic dust exposure: A potential role of L-selectin shedding? . Eur. Respir. J. , 19 : 833 – 837 .
  • Ivanov , S. , Palmberg , L. , Venge , P. , Larsson , K. and Linden , A. 2005 . Interleukin-17A mRNA and protein expression within cells from the human bronchoalveolar space after exposure to organic dust . Respir. Res. , 6 : 44
  • Key, N., and McBride, W. D. 2008. Amber waves. The economics of food, farming, natural resources, and rural America. Technology, larger farm size increased productivity on U.S. hog farms. http://webarchives.cdlib.org/sw1vh5dg3r/http://ers.usda.gov/AmberWaves/April08/Features/USHogFarms.htm (http://webarchives.cdlib.org/sw1vh5dg3r/http://ers.usda.gov/AmberWaves/April08/Features/USHogFarms.htm)
  • Kilburn , K. H. 1984 . Particles causing lung disease . Environ. Health Perspect. , 55 : 97 – 109 .
  • Kirkhorn , S. R. and Garry , V. F. 2000 . Agricultural lung diseases . Environ. Health Perspect. , 108 : 705 – 712 .
  • Klintberg , B. , Berglund , N. , Lilja , G. , Wickman , M. and van Hage-Hamsten , M. 2001 . Fewer allergic respiratory disorders among farmers’ children in a closed birth cohort from Sweden . Eur. Respir. J. , 17 : 1151 – 1157 .
  • Kogevinas , M. , Anto , J. M. , Sunyer , J. , Tobias , A. , Kromhout , H. and Burney , P. 1999 . Occupational asthma in europe and other industrialised areas: A population-based study. european community respiratory health survey study group . Lancet , 353 : 1750 – 1754 .
  • Larsson , B. M. , Larsson , K. , Malmberg , P. and Palmberg , L. 2002 . Airways inflammation after exposure in a swine confinement building during cleaning procedure . Am. J. Ind. Med. , 41 : 250 – 258 .
  • Larsson , B. M. , Larsson , K. , Malmberg , P. and Palmberg , L. 1999 . Gram positive bacteria induce IL-6 and IL-8 production in human alveolar macrophages and epithelial cells . Inflammation , 23 : 217 – 230 .
  • Larsson , B. M. , Palmberg , L. , Malmberg , P. O. and Larsson , K. 1997 . Effect of exposure to swine dust on levels of IL-8 in airway lavage fluid . Thorax , 52 : 638 – 642 .
  • Larsson , K. A. , Eklund , A. G. , Hansson , L. O. , Isaksson , B. M. and Malmberg , P. O. 1994 . Swine dust causes intense airways inflammation in healthy subjects . Am. J. Respir. Crit. Care Med. , 150 : 973 – 977 .
  • Lawson , J. A. , Dosman , J. A. , Rennie , D. C. , Beach , J. , Newman , S. C. and Senthilselvan , A. 2011 . The association between endotoxin and lung function among children and adolescents living in a rural area . Can. Respir. J. , 18 : e89 – e94 .
  • Lawson , J. A. , Dosman , J. A. , Rennie , D. C. , Beach , J. , Newman , S. C. and Senthilselvan , A. 2011 . Relationship of endotoxin and tobacco smoke exposure to wheeze and diurnal peak expiratory flow variability in children and adolescents . Respirology , 16 : 332 – 339 .
  • Letourneau , V. , Nehme , B. , Meriaux , A. , Masse , D. , Cormier , Y. and Duchaine , C. 2010a . Human pathogens and tetracycline-resistant bacteria in bioaerosols of swine confinement buildings and in nasal flora of hog producers . Int. J. Hyg. Environ. Health , 213 : 444 – 449 .
  • Letourneau , V. , Nehme , B. , Meriaux , A. , Masse , D. and Duchaine , C. 2010b . Impact of production systems on swine confinement buildings bioaerosols . J. Occup. Environ. Hyg. , 7 : 94 – 102 .
  • LeVan , T. D. , Von Essen , S. , Romberger , D. J. , Lambert , G. P. , Martinez , F. D. , Vasquez , M. M. and Merchant , J. A. 2005 . Polymorphisms in the CD14 gene associated with pulmonary function in farmers . Am. J. Respir. Crit. Care Med. , 171 : 773 – 779 .
  • Mathisen , T. , Von Essen , S. G. , Wyatt , T. A. and Romberger , D. J. 2004 . Hog barn dust extract augments lymphocyte adhesion to human airway epithelial cells . J. Appl. Physiol. , 96 : 1738 – 1744 .
  • May , J. J. , Stallones , L. , Darrow , D. and Pratt , D. S. 1986 . Organic dust toxicity (pulmonary mycotoxicosis) associated with silo unloading . Thorax , 41 : 919 – 923 .
  • Mayeux , P. R. 1997 . Pathobiology of lipopolysaccharide . J. Toxicol. Environ. Health , 51 : 415 – 435 .
  • Merchant , J. A. , Naleway , A. L. , Svendsen , E. R. , Kelly , K. M. , Burmeister , L. F. , Stromquist , A. M. , Taylor , C. D. , Thorne , P. S. , Reynolds , S. J. , Sanderson , W. T. and Chrischilles , E. A. 2005 . Asthma and farm exposures in a cohort of rural Iowa children . Environ. Health Perspect. , 113 : 350 – 356 .
  • Monso , E. , Riu , E. , Radon , K. , Magarolas , R. , Danuser , B. , Iversen , M. , Morera , J. and Nowak , D. 2004 . Chronic obstructive pulmonary disease in never-smoking animal farmers working inside confinement buildings . Am. J. Ind. Med. , 46 : 357 – 362 .
  • Nehme , B. , Gilbert , Y. , Letourneau , V. , Forster , R. J. , Veillette , M. , Villemur , R. and Duchaine , C. 2009 . Culture-independent characterization of archaeal biodiversity in swine confinement building bioaerosols . Appl. Environ. Microbiol. , 75 : 5445 – 5450 .
  • Nehme , B. , Letourneau , V. , Forster , R. J. , Veillette , M. and Duchaine , C. 2008 . Culture-independent approach of the bacterial bioaerosol diversity in the standard swine confinement buildings, and assessment of the seasonal effect . Environ. Microbiol. , 10 : 665 – 675 .
  • O'Connor , A. M. , Auvermann , B. , Bickett-Weddle , D. , Kirkhorn , S. , Sargeant , J. M. , Ramirez , A. and Von Essen , S. G. 2010 . The association between proximity to animal feeding operations and community health: A systematic review . PloS One e9530. , 5
  • Omland , O. 2002 . Exposure and respiratory health in farming in temperate zones—A review of the literature . Ann. Agric. Environ. Med. , 9 : 119 – 136 .
  • Palmberg , L. , Larssson , B. M. , Malmberg , P. and Larsson , K. 2002 . Airway responses of healthy farmers and nonfarmers to exposure in a swine confinement building . Scand. Work Environ. Health , 28 : 256 – 263 .
  • Pedersen , B. , Iversen , M. , Bundgaard Larsen , B. and Dahl , R. 1996 . Pig farmers have signs of bronchial inflammation and increased numbers of lymphocytes and neutrophils in BAL fluid . Eur. Respir. J. , 9 : 524 – 530 .
  • Pekkanen , J. , Xu , B. and Jarvelin , M. R. 2001 . Gestational age and occurrence of atopy at age 31--a prospective birth cohort study in Finland . Clin. Exp. Allergy , 31 : 95 – 102 .
  • Poole , J. A. , Alexis , N. E. , Parks , C. , MacInnes , A. K. , Gentry-Nielsen , M. J. , Fey , P. D. , Larsson , L. , Allen-Gipson , D. , Von Essen , S. G. and Romberger , D. J. 2008 . Repetitive organic dust exposure in vitro impairs macrophage differentiation and function . J. Allergy Clin. Immunol. , 122 : 375 – 382 .
  • Poole , J. A. , Dooley , G. P. , Saito , R. , Burrell , A. M. , Bailey , K. L. , Romberger , D. J. , Mehaffy , J. and Reynolds , S. J. 2010 . Muramic acid, endotoxin, 3-hydroxy fatty acids, and ergosterol content explain monocyte and epithelial cell inflammatory responses to agricultural dusts . J. Toxicol. Environ. Health A , 73 : 684 – 700 .
  • Poole , J. A. , Kielian , T. , Wyatt , T. A. , Gleason , A. M. , Stone , J. , Palm , K. , West , W. W. and Romberger , D. J. 2011a . Organic dust augments nucleotide-binding oligomerization domain expression via an NF-{kappa}B pathway to negatively regulate inflammatory responses . Am. J. Physiol. Lung Cell Mol. Physiol. , 301 : L296 – L306 .
  • Poole , J. A. , LeVan , T. D. , Slager , R. E. , Qiu , F. , Severa , L. , Yelinek , J. , Carlson , M. L. , Bush , J. , Bolin , N. , Wyatt , T. A. , Romberger , D. and Von Essen , S. G. 2007a . Bronchodilator responsiveness in swine veterinarians . J. Agromed. , 12 : 49 – 54 .
  • Poole , J. A. , Wyatt , T. A. , Kielian , T. , Oldenburg , P. , Gleason , A. M. , Bauer , A. , Golden , G. , West , W. W. , Sisson , J. H. and Romberger , D. J. 2011b . Toll-like receptor 2 regulates organic dust-induced airway inflammation . Am. J. Respir. Cell Mol. Biol. , 45 : 711 – 719 .
  • Poole , J. A. , Wyatt , T. A. , Oldenburg , P. J. , Elliott , M. K. , West , W. W. , Sisson , J. H. , Von Essen , S. G. and Romberger , D. J. 2009 . Intranasal organic dust exposure-induced airway adaptation response marked by persistent lung inflammation and pathology in mice . Am. J. Physiol. Lung Cell Mol. Physiol. , 296 : L1085 – L1095 .
  • Poole , J. A. , Wyatt , T. A. , Von Essen , S. G. , Hervert , J. , Parks , C. , Mathisen , T. and Romberger , D. J. 2007b . Repeat organic dust exposure-induced monocyte inflammation is associated with protein kinase C activity . J. Allergy Clin. Immunol. , 120 : 366 – 373 .
  • Poole , J. A. , Gleason , A. M. , Bauer , C. , West , W. W. , Alexis , N. , Reynolds , S. J. , Romberger , D. J. and Kielian , T. 2012 . αβ T cells and a mixed Th1/Th17 response are important in organic dust-induced airway disease . Ann. Allergy Asthma Immunol. , 109 : 266 – 273 .
  • Portengen , L. , Sigsgaard , T. , Omland , O. , Hjort , C. , Heederik , D. and Doekes , G. 2002 . Low prevalence of atopy in young Danish farmers and farming students born and raised on a farm . Clin. Exp. Allergy , 32 : 247 – 253 .
  • Radon , K. , Ehrenstein , V. , Praml , G. and Nowak , D. 2004 . Childhood visits to animal buildings and atopic diseases in adulthood: An age-dependent relationship . Am. J. Ind. Med. , 46 : 349 – 356 .
  • Rask-Andersen , A. , Malmberg , P. and Lundholm , M. 1989 . Endotoxin levels in farming: Absence of symptoms despite high exposure levels . Br. J. Ind. Med. , 46 : 412 – 416 .
  • Reed , C. E. and Milton , D. K. 2001 . Endotoxin-stimulated innate immunity: A contributing factor for asthma . J. Allergy Clin. Immunol. , 108 : 157 – 166 .
  • Rennie , D. C. , Lawson , J. A. , Senthilselvan , A. , Willson , P. J. and Dosman , J. A. 2012 . Domestic endotoxin exposure and asthma in children: Epidemiological studies . Front. Biosci. , 4 : 56 – 73 .
  • Reynolds , S. J. , Donham , K. J. , Whitten , P. , Merchant , J. A. , Burmeister , F. and Popendorf , W. J. 1996 . Longitudinal evaluation of dose-response relationships for environmental exposures and pulmonary function in swine production workers . Am. J. Ind. Med. , 29 : 33 – 40 .
  • Riedler , J. , Eder , W. , Oberfeld , G. and Schreuer , M. 2000 . Austrian children living on a farm have less hay fever, asthma and allergic sensitization . Clin. Exp. Allergy , 30 : 194 – 200 .
  • Romberger , D. J. , Bodlak , V. , Von Essen , S. G. , Mathisen , T. and Wyatt , T. A. 2002 . Hog barn dust extract stimulates IL-8 and IL-6 release in human bronchial epithelial cells via PKC activation . J. Appl. Physiol. , 93 : 289 – 296 .
  • Schwartz , D. A. , Donham , K. J. , Olenchock , S. A. , Popendorf , W. J. , Van Fossen , D. S. , Burmeister , L. F. and Merchant , J. A. 1995 . Determinants of longitudinal changes in spirometric function among swine confinement operators and farmers . Am. J. Respir. Crit. Care Med. , 151 : 47 – 53 .
  • Senthilselvan , A. , Dosman , J. A. , Chenard , L. , Burch , L. H. , Predicala , B. Z. , Sorowski , R. , Schneberger , D. , Hurst , T. , Kirychuk , S. , Gerdts , V. , Cormier , Y. , Rennie , D. C. and Schwartz , D. A. 2009 . Toll-like receptor 4 variants reduce airway response in human subjects at high endotoxin levels in a swine facility . J. Allergy Clin. Immunol. , 123 : 1034 – 1040 .
  • Senthilselvan , A. , Rennie , D. , Chenard , L. , Burch , L. H. , Babiuk , L. , Schwartz , D. A. and Dosman , J. A. 2008 . Association of polymorphisms of toll-like receptor 4 with a reduced prevalence of hay fever and atopy . Ann Allergy Asthma Immunol , 100 : 463 – 468 .
  • Slager , R. E. , Allen-Gipson , D. S. , Sammut , A. , Heires , A. , DeVasure , J. , Von Essen , S. , Romberger , D. J. and Wyatt , T. A. 2007 . Hog barn dust slows airway epithelial cell migration in vitro through a PKC alpha-dependent mechanism . Am. J. Physiol. Lung Cell Mol. Physiol , 293 : L1469 – L1474 .
  • Slager , R. E. , Simpson , S. L. , Levan , T. D. , Poole , J. A. , Sandler , D. P. and JHoppin , J. A. 2010 . Rhinitis associated with pesticide use among private pesticide applicators in the agricultural health study . J. Toxicol. Environ. Health A , 73 : 1382 – 1393 .
  • Sundblad , B. M. , Larsson , B. M. , Palmberg , L. and Larsson , K. 2002 . Exhaled nitric oxide and bronchial responsiveness in healthy subjects exposed to organic dust . Eur. Respir. J. , 20 : 426 – 431 .
  • Sundblad , B. M. , von Scheele , I. , Palmberg , L. , Olsson , M. and Larsson , K. 2009 . Repeated exposure to organic material alters inflammatory and physiological airway responses . Eur. Respir. J. , 34 : 80 – 88 .
  • Szponar , B. and Larsson , L. 2001 . Use of mass spectrometry for characterising microbial communities in bioaerosols . Ann. Agric. Environ. Med. , 8 : 111 – 117 .
  • Tarlo , S. M. and Liss , G. M. 2003 . Occupational asthma: An approach to diagnosis and management . Can. Med. Assoc. J. , 168 : 867 – 871 .
  • Tarlo , S. M. and Malo , J. L. 2009 . Third Jack Pepys Workshop on Asthma in the Workplace Participants . An official ATS proceedings: Asthma in the workplace: The third Jack Pepys Workshop on Asthma in the Workplace: Answered and unanswered questions.Proc. Am. Thorac. Soc , 6 : 339 – 349 .
  • U.S. Department of Agriculture. 2009. The economics of food, farming, natural resources, and rural America. Economic Research Service. www.ers.usda.gov/briefing/cattle/background.htm (http://www.ers.usda.gov/briefing/cattle/background.htm)
  • Vogelzang , P. F. , van der Gulden , J. W. , Folgering , H. , Kolk , J. J. , Heederik , D. , Preller , L. , Tielen , M. J. and van Schayck , C. P. 1998 . Endotoxin exposure as a major determinant of lung function decline in pig farmers . Am. J. Respir. Crit. Care Med. , 157 : 15 – 18 .
  • Vogelzang , P. F. , van der Gulden , J. W , Tielen , M. J. , Folgering , H. and van Schayck , C. P. 1999 . Health-based selection for asthma, but not for chronic bronchitis, in pig farmers: An evidence-based hypothesis . Eur. Respir. J. , 13 : 187 – 189 .
  • Von Essen , S. and Donham , K. 1999 . Illness and injury in animal confinement workers . Occup. Med. , 14 : 337 – 350 .
  • Von Essen , S. , Moore , G. , Gibbs , S. and Larson , K. L. 2010 . Respiratory issues in beef and pork production: Recommendations from an expert panel . J. Agromed. , 15 : 216 – 225 .
  • Von Essen , S. and Romberger , D. 2003 . The respiratory inflammatory response to the swine confinement building environment: The adaptation to respiratory exposures in the chronically exposed worker . J. Agric. Safety Health , 9 : 185 – 196 .
  • Von Essen , S. G. , Thompson , A. B. , Robbins , R. A. , Jones , K. K. , Dobry , C. A. and Rennard , S. I. 1990 . Lower respiratory tract inflammation in grain farmers . Am. J. Ind. Med. , 1 : 75 – 76 .
  • Von Scheele , I. , Larsson , K. and Palmberg , L. 2010 . Budesonide enhances toll-like receptor 2 expression in activated bronchial epithelial cells . Inhal. Toxicol. , 22 : 493 – 499 .
  • Wyatt , T. A. , Slager , R. E. , Devasure , J. , Auvermann , B. W. , Mulhern , M. L. , Von Essen , S. , Mathisen , T. , Floreani , A. A. and Romberger , D. J. 2007 . Feedlot dust stimulation of interleukin-6 and -8 requires protein kinase c epsilon in human bronchial epithelial cells . Am. J. Physiol. Lung Cell Mol. Physiol. , 293 : L1163 – L1170 .
  • Wyatt , T. A. , Slager , R. E. , Heires , A. J. , DeVasure , J. M. , Von Essen , S. G. and Romberger , D. J. 2010 . Sequential activation of protein kinase C isoforms by organic dust is mediated by tumor necrosis factor . Am. J. Respir. Cell Mol. Biol. , 42 : 706 – 715 .
  • Zejda , J. E. , Hurst , T. S. , Rhodes , C. S. , Barber , E. M. , McDuffie , H. H. and Dosman , J. A. 1993 . Respiratory health of swine producers. Focus on young workers . Chest , 103 : 702 – 709 .
  • Zhiping , W. , Malmberg , P. , Larsson , B. M. , Larsson , K. , Larsson , L. and Saraf , A. 1996 . Exposure to bacteria in swine-house dust and acute inflammatory reactions in humans . Am. J. Respir. Crit. Care Med. , 154 : 1261 – 1266 .

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