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Is Triclosan a neurotoxic agent?

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References

  • Adgent MA, Rogan WJ. 2015. Triclosan and prescription antibiotic exposures and enterolactone production in adults. Environ Res. 142: 66–71.
  • Adibhatla RM, Hatcher JF. 2008. Altered lipid metabolism in brain injury and disorders. Subcell Biochem. 49: 241–268.
  • Ahn KC, Zhao B, Chen J, Cherednichenko G, Sanmarti E, Denison MS, Lasley B, Pessah IN, Kültz D, Chang DPY, Gee SJ, Hammock BD. 2008. In vitro biologic activities of the antimicrobials triclocarban, its analogs, and triclosan in bioassay screens: Receptor-based bioassay screens. Environ Health Persp. 116: 1203–1210.
  • Ajao C, Andersson MA, Teplova VV, Nagy S, Gahmberg CG, Andersson LC, Hautaniemi M, Kakasi B, Roivainen M, Salkinoja-Salonen M. 2015. Mitochondrial toxicity of triclosan on mammalian cells. Toxicol Rep. 2: 624–637.
  • Allmyr M, Adolfsson-Erici M, McLachlan MS, Sandborgh-Englund G. 2006. Triclosan in plasma and milk from Swedish nursing mothers and their exposure via personal care products. Sci Total Environ. 372: 87–93.
  • Allmyr M, Harden F, Toms LM, Mueller JF, McLachlan MS, Adolfsson-Erici M, Sandborgh-Englund G. 2008. The influence of age and gender on triclosan concentrations in Australian human blood serum. Sci Total Environ. 393:162–167.
  • Anderson SE, Franko J, Kashon ML Anderson KL, Hubbs AF, Lukomska E, Meade BJ. 2013. Exposure to triclosan augments allergic response to ovalbumin in a mouse model of asthma. Toxicol Sci. 132: 96–106.
  • Anderson SE, Meade JB, Long CM, Lukomska E, Marshall NB. 2016. Investigations of immunotoxicity and allergic potential induced by topical application of triclosan in mice. J Immunotoxicol. 13: 165–172.
  • Arbuckle TE, Weiss L, Fisher M, Hauser R, Dumas P, Bérubé R, Neisa A, LeBlanc A, Lang C, Ayotte P, Walker M, Feeley M, Koniecki D, Tawagi G. 2015. Maternal and infant exposure to environmental phenols as measured in multiple biological matrices. Sci Total Environ. 508: 575–584.
  • Attene-Ramos MS, Huang R, Michael S, Witt KL, Richard A, Tice RR, Simeonov A, Austin CP, Xia M. 2015. Profiling of the Tox21 chemical collection for mitochondrial function to identify compounds that acutely decrease mitochondrial membrane potential. Environ Health Persp. 123: 49–56.
  • Axelstad M, Boberg J, Vinggaard AM, Christiansen S, Hass U. 2013. Triclosan exposure reduces thyroxine levels in pregnant and lactating rat dams and in directly exposed offspring. Food Chem Toxicol. 59: 534–540.
  • Bagley DM, Lin YJ. 2000. Clinical evidence for the lack of triclosan accumulation from daily use in dentifrices. Am J Dent. 13:148–152.
  • Barth C, Villringer A, Sacher J. 2015. Sex hormones affect neurotransmitters and shape the adult female brain during hormonal transition periods. Front Neurosci. 9: 1–20.
  • Belen Rabaglino M, Chang EI, Richards EM, James MO, Keller-Wood M, Wood CE. 2016. Genomic effect of triclosan on the fetal hypothalamus: Evidence for altered neuropeptide regulation. Endocrinology. 157: 2686–2697.
  • Bedoux G, Roig B, Thomas O, Dupont V, Le Bot B. 2012. Occurrence and toxicity of antimicrobial triclosan and by-products in the environment. Environ Sci Pollut Res. 19: 1044–1065.
  • Berlin CM Jr, Kacew S, Lawrence R, LaKind JS, Campbell R. 2002. Criteria for chemical selection for programs on human milk surveillance and research for environmental chemicals. J Toxicol Environ Health A. 65: 1839–1851.
  • Bertelsen RJ, Longnecker MP, Løvik M, Calafat AM, Carlsen KH, London SJ, Lødrup Carlsen KC. 2013. Triclosan exposure and allergic sensitization in Norwegian children. Allergy. 68: 84–91.
  • Bhat AH, Dar KB, Anees S, Zargar MA, Masood A, Sofi MA, Ganie SA. 2015. Oxidative stress, mitochondrial dysfunction and neurodegenerative diseases; A mechanistic insight. Biomed Pharmacother. 74: 101–110.
  • Binelli A, Cogni D, Parolini M, Riva C, Provini A. 2009. In vivo experiments for the evaluation of genotoxic and cytotoxic effects of triclosan in zebra mussel hemocytes. Aquat Toxicol. 91: 238–244.
  • Blesa J, Trigo-Damas I, Quiroga-Varela A, Jackson-Lewis VR. 2015. Oxidative stress and Parkinson’s disease. Front Neuroanat. 9: 91.
  • Brusselmans K, Swinnen J. 2009. The lipogenic switch in cancer. In Mitochondria and Cancer. Singh KK, Costello LC (Eds.). Springer, New York. pp. 39–59.
  • Butt CM, Wang D, Stapleton HM. 2011. Halogenated phenolic contaminants inhibit the in vitro activity of the thyroid-regulating deiodinases in human liver. Toxicol Sci. 124: 339–347.
  • Calafat AM, Ye X, Wong LY, Reidy JA, Needham LL. 2008. Urinary concentrations of triclosan in the U.S. population: 2003-2004. Environ Health Persp. 116: 303–307.
  • Calì T, Ottolini D, Brini M. 2014. Calcium signaling in Parkinson’s disease. Cell Tissue Res. 357: 439–454.
  • Chen J, Ahn KC, Gee NA, Gee SJ, Hammock BD, Lasley BL. 2007. Antiandrogenic properties of parabens and other phenolic containing small molecules in personal care products. Toxicol Appl Pharmacol. 221: 278–284.
  • Cherednichenko G, Zhang R, Bannister RA, Timofeyev V, Li N, Fritsch EB, Feng W, Barrientos GC, Schebb NH, Hammock BD, Beam KG, Chiamvimonvat N, Pessah IN. 2012. Triclosan impairs excitation-contraction coupling and Ca2+ dynamics in striated muscle. Proc Natl Acad Sci USA. 109: 4158–14163.
  • Chiurchiù V, Orlacchio A, Maccarrone M. 2016. Is modulation of oxidative stress an answer? The state of the art of redox therapeutic actions in neurodegenerative diseases. Oxid Med Cell Longev. 7909380.
  • Ciniglia C, Cascone C, Giudice RL, Pinto G, Pollio A. 2005. Application of methods for assessing the geno- and cytotoxicity of triclosan to C. ehrenbergii. J Hazard Mater. 122: 227–232.
  • Clayton EM, Todd M, Dowd JB, Aiello AE. 2011. The impact of bisphenol A and triclosan on immune parameters in the U.S. population, NHANES 2003–2006. Environ Health Persp. 119: 390–396.
  • Cosentino K, García-Sáez AJ. 2014. Mitochondrial alterations in apoptosis. Chem Phys Lipids. 181: 62–75.
  • Crofton K, Paul KB, DeVito MJ, Hedge JM. 2007. Short-term in vivo exposure to the water contaminant triclosan: Evidence for disruption of thyroxine. Environ Toxicol Pharmacol. 24: 194–197.
  • Dann AB, Hontela A. 2011. Triclosan: Environmental exposure, toxicity and mechanisms of action. J Appl Toxicol. 31: 285–311.
  • Dayan AD. 2007. Risk assessment of triclosan [Irgasan®] in human breast milk. Food Chem Toxicol. 45: 125–129.
  • De Virgilio A, Greco A, Fabbrini G, Inghilleri M, Rizzo MI, Gallo A, Conte M, Rosato C, Ciniglio AM, de Vincentiis M. 2016. Parkinson’s disease: Autoimmunity and neuroinflammation. Autoimmun Rev. 15: 1005–1011.
  • Deepa PR, Vandhana S, Jayanthi U, Krishnakumar S. 2012. Therapeutic and toxicologic evaluation of anti-lipogenic agents in cancer cells compared with non-neoplastic cells. Basic Clin Pharm Toxicol. 110: 494–503.
  • Deepa PR, Vandhana S, Muthukumaran S, Umashankar V, Jayanthi U, Krishnakumar S. 2010. Chemical inhibition of fatty acid synthase: Molecular docking analysis and biochemical validation in ocular cancer cells. J Ocul Biol Dis Infor. 3: 117–128.
  • Delorenzo ME, Keller JM, Arthur CD, Finnegan MC, Harper HE, Winder VL, Zdankiewicz DL. 2008. Toxicity of the antimicrobial compound triclosan and formation of the metabolite methyl-triclosan in estuarine systems. Environ Toxicol. 23: 224–232.
  • Dhillon GS, Kaur S, Pulicharla R, Brar SK, Cledón M, Verma M, Surampalli RY. 2015. Triclosan: current status, occurrence, environmental risks and bioaccumulation potential. Int J Environ Res Public Health. 12: 5657–5684.
  • Dinwiddie MT, Terry PD, Chen J. 2014. Recent evidence regarding triclosan and cancer risk. Int J Environ Res Public Health. 11: 2209–2217.
  • Dirtu AC, Roosens L, Geens T, Gheorghe A, Neels H, Covaci A. 2008. Simultaneous determination of bisphenol A, triclosan, and tetrabromobisphenol A in human serum using solid-phase extraction and gas chromatography-electron capture negative-ionization mass spectrometry. Anal Bioanal Chem. 391: 1175–1181.
  • Escarrone AL, Caldas SS, Primel EG, Martins SE, Nery LE. 2016. Uptake, tissue distribution and depuration of triclosan in the guppy Poecilia vivipara acclimated to freshwater. Sci Total Environ. 560–561:218–224.
  • Fakhoury M. 2016. Immune-mediated processes in neurodegeneration: Where do we stand? J Neurol. 263: 1683–1701.
  • Falfushynska HI, Gnatyshyna LL, Osadchuk OY, Farkas A, Vehovszky A, Carpenter DO, Gyori J, Stoliar OB. 2014. Diversity of the molecular responses to separate wastewater effluents in freshwater mussels. Comp Biochem Physiol C Toxicol Pharmacol. 164: 51–58.
  • Fang JL, Stingley RL, Beland FA, Harrouk W, Lumpkins DL, Howard P. 2010. Occurrence, efficacy, metabolism, and toxicity of triclosan. J Environ Sci Health C Environ Carcinogen Ecotoxicol Rev. 28:147–171.
  • Fang JL, Vanlandingham M, da Costa GG, Beland FA. 2016. Absorption and metabolism of triclosan after application to the skin of B6C3F1 mice. Environ Toxicol. 31: 609–623.
  • FDA. 2016. Safety and effectiveness of consumer antiseptics; topical antimicrobial drug products for over-the-counter human use. 81FR61106.
  • Foran CM, Bennett ER, Benson WH. 2000. Developmental evaluation of a potential non-steroidal estrogen: Triclosan. Mar Environ Res. 50:153–156.
  • Fritsch EB, Connon RE, Werner I, Davies R, Beggel S, Feng W, Pessah IN. 2013. Triclosan impairs swimming behavior and alters expression of excitation contraction coupling proteins in fathead minnow (Pimephales promelas). Environ Sci Technol. 47: 2008–2017.
  • Gee RH, Charles A, Taylor N, Darbre PD. 2008. Oestrogenic and androgenic activity of triclosan in breast cancer cells. J Appl Toxicol. 28: 78–91.
  • Geens T, Neels H, Covaci A. 2012 Distribution of bisphenol A, triclosan and n-nonylphenol in human adipose tissue, liver and brain. Chemosphere. 87: 796–802.
  • Ghassabian A, Bongers-Schokking JJ, Henrichs J, Jaddoe VW, Visser TJ, Visser W, de Muinck Keizer-Schrama SM, Hooijkaas H, Steegers EA, Hofman A, Verhulst FC, van der Ende J, de Rijke YB, Tiemeier H. 2011. Maternal thyroid function during pregnancy and behavioral problems in the offspring: The generation R study. Pediatr Res. 69: 454–459.
  • Giannini G, Conti A, Mammarella S, Scrobogna M, Sorrentino V. 1995. The ryanodine receptor/calcium channel genes are widely and differentially expressed in murine brain and peripheral tissues. J Cell Biol. 128: 893–904.
  • Giuliano CA, Rybak MJ. 2015. Efficacy of triclosan as an antimicrobial hand soap and its potential impact on antimicrobial resistance: A focused review. Pharmacotherapy. 35: 328–336.
  • Gou N, Yuan S, Lan J, Gao C, Alshawabkeh AN, Gu AZ. 2014. A quantitative toxicogenomics assay reveals the evolution and nature of toxicity during the transformation of environmental pollutants. Environ Sci Technol. 48: 8855–8863.
  • Guo LW, Wu Q, Green B, Nolen G, Shi L, Lo Surdo J, Deng H, Bauer S, Fang JL, Ning B. 2012. Cytotoxicity and inhibitory effects of low-concentration triclosan on adipogenic differentiation of human mesenchymal stem cells. Toxicol Appl Pharmacol. 262: 117–123.
  • Halladin NL. 2015. Oxidative and inflammatory biomarkers of ischemia and reperfusion injuries. Danish Med J. 62:B5054.
  • Henrichs J, Bongers-Schokking JJ, Schenk JJ, Ghassabian A, Schmidt HG, Visser TJ, Hooijkaas H, de Muinck Keizer-Schrama SM, Hofman A, Jaddoe VV, Visser W, Steegers EA, Verhulst FC, de Rijke YB, Tiemeier H. 2010. Maternal thyroid function during early pregnancy and cognitive functioning in early childhood: The generation R study. J Clin Endocrinol Metab. 95: 4227–4234.
  • Henry ND, Fair PA. 2013. Comparison of in vitro cytotoxicity, estrogenicity and anti-estrogenicity of triclosan, perfluorooctane sulfonate and perfluorooctanoic acid. J Appl Toxicol. 33: 265–272.
  • Ho JC, Hsiao CD, Kawakami K, Tse WK. 2016. Triclosan (TCS) exposure impairs lipid metabolism in zebrafish embryos. Aquat Toxicol. 173: 29–35.
  • Honkisz E, Zieba-Przybylska D, Wojtowicz AK. 2012. The effect of triclosan on hormone secretion and viability of human choriocarcinoma JEG-3 cells. Reprod Toxicol. 34: 385–392.
  • Huo DS, Sun JF, Zhang B, Yan XS, Wang H, Jia JX, Yang ZJ. 2016. Protective effects of testosterone on cognitive dysfunction in Alzheimer’s disease model rats induced by oligomeric beta amyloid peptide 1-42. J Toxicol Environ Health A. 79: 856–863.
  • Ishibashi H, Matsumura N, Hirano M, Matsuoka M, Shiratsuchi H, Ishibashi Y, Takao Y, Arizono K. 2004. Effects of triclosan on the early life stages and reproduction of medaka Oryzias latipes and induction of hepatic vitellogenin. Aquat Toxicol. 67: 167–179.
  • James MO, Li W, Summerlot DP, Rowland-Faux L, Wood CE. 2010. Triclosan is a potent inhibitor of estradiol and estrone sulfonation in sheep placenta. Environ Int. 36: 942–949.
  • Jia JX, Cui CL, Yan XS, Zhang BF, Song W, Huo DS, Wang H, Yang ZJ. 2016. Effects of testosterone on synaptic plasticity mediated by androgen receptors in male SAMP8 mice. J Toxicol Environ Health A. 79: 849–855.
  • Jirasripongpun K, Wongarethornkul T, Mulliganavin S. 2008. Risk assessment of triclosan using animal cell lines. Kasetsart J (Nat Sci). 42: 353–359.
  • Johnson PI, Koustas E, Vesterinen HM, Sutton P, Atchley DS, Kim AN, Campbell M, Donald JM, Sen S, Bero L, Zeise L, Woodruff TJ. 2016. Application of the Navigation Guide systematic review methodology to the evidence for developmental and reproductive toxicity of triclosan. Environ Int. 92–93:716–728.
  • Jones RD, Jampani HB, Newman JL, Lee AS. 2000. Triclosan: A review of effectiveness and safety in health care settings. Am J Infect Control. 28: 184–196.
  • Jung EM, An BS, Choi KC, Jeung EB. 2012. Potential estrogenic activity of triclosan in the uterus of immature rats and rat pituitary GH3 cells. Toxicol Lett. 208: 142–148.
  • Kanetoshi A, Katsura E, Ogawa H, Ohyama T, Kaneshima H, Miura T. 1992. Acute toxicity, percutaneous absorption and effects on hepatic mixed function oxidase activities of 2,4,4’-trichloro-2’-hydroxydiphenyl ether (Irgasan DP300) and its chlorinated derivatives. Arch Environ Contam Toxicol. 23: 91–98.
  • Kim GH, Kim JE, Rhie SJ, Yoon S. 2015. The role of oxidative stress in neurodegenerative diseases. Exp Neurobiol. 24: 325–340.
  • Kim JY, Yi BR, Go RE, Hwang KA, Nam KH, Choi KC. 2014. Methoxychlor and triclosan stimulates ovarian cancer growth by regulating cell cycle- and apoptosis-related genes via an estrogen receptor dependent pathway. Environ Toxicol Pharmacol. 37: 1264–1274.
  • Knobloch M, Braun SMG, Zurkirchen L, von Schoultz C, Zamboni N, Arauzo-Bravo MJ, Kovacs WJ, Karalay Ö, Suter U, Machado RAC, Roccio M, Lutolf MP, Semenkovich CF, Jessberger S. 2013. Metabolic control of adult neural stem cell activity by Fasn-dependent lipogenesis. Nature. 493: 226–230.
  • Kolpin DW, Furlong ET, Meyer MT, Thurman EM, Zaugg SD, Barber LB, Buxton HT. 2002. Pharmaceuticals, hormones, and other organic wastewater contaminants in U.S. streams, 1999-2000: a national reconnaissance. Environ Sci Technol. 36: 1202–1211.
  • Kumar V, Chakraborty A, Kural MR, Roy P. 2009. Alteration of testicular steroidogenesis and histopathology of reproductive system in male rats treated with triclosan. Reprod Toxicol. 27: 177–185.
  • Kumar VS, Gopalakrishnan A, Naziroğlu M, Rajanikant GK. 2014. Calcium ion – the key player in cerebral ischemia. Curr Med Chem. 21: 2065–2075.
  • Kumar KS, Priya SM, Peck AM, Sajwan KS. 2010. Mass loadings of triclosan and triclocarbon from four wastewater treatment plants to three rivers and landfill in Savannah, Georgia, USA. Arch Environ Contam Toxicol. 58: 275–285.
  • Kwon JT, Yang YS, Kang MS, Seo GB, Lee DH, Yang MJ, Shim I, Kim HM, Kim P, Choi K, Lee K. 2013. Pulmonary toxicity screening of triclosan in rats after intratracheal instillation. J Toxicol Sci. 38: 471–475.
  • Kyung Park B, Gonzales EDT, Min Yang S, Bang M, Soon Choi C, Young Shin C. 2016. Effects of triclosan on neural stem cell viability and survival. Biomol Ther (Seoul). 24: 99–107.
  • Lassen TH, Frederiksen H, Kyhl HB, Swan SH, Main KM, Andersson AM, Lind DV, Husby S, Wohlfahrt-Veje C, Skakkebæk NE, Jensen TK. 2016. Prenatal triclosan exposure and anthropometric measures including anogenital distance in Danish Infants. Environ Health Persp. 124: 1261–1268.
  • Lee HR, Hwang KA, Nam KH, Kim HC, Choi KC. 2014. Progression of breast cancer cells was enhanced by endocrine-disrupting chemicals, triclosan and octylphenol, via an estrogen receptor-dependent signaling pathway in cellular and mouse xenograft models. Chem Res Toxicol. 27: 834–842.
  • Li Y, Shan Z, Teng W, Yu X, Li Y, Fan C, Teng X, Guo R, Wang H, Li J, Chen Y, Wang W, Chawinga M, Zhang L, Yang L, Zhao Y, Hua T. 2010. Abnormalities of maternal thyroid function during pregnancy affect neuropsychological development of their children at 25–30 months. Clin Endocrinol (Oxf). 72: 825–829.
  • Lin YJ. 2000. Buccal absorption of triclosan following topical mouth rinse application. Am J Dent. 13: 215–217.
  • Lin D, Li Y, Zhou Q, Xu Y, Wang D. 2014. Effect of triclosan on reproduction, DNA damage and heat shock protein gene expression of the earthworm Eisenia fetida. Ecotoxicology. 23: 1826–1832.
  • Lin D, Xie X, Zhou Q, Liu Y. 2012. Biochemical and genotoxic effect of triclosan on earthworms (Eisenia fetida) using contact and soil tests. Environ Toxicol. 27: 385–392.
  • Liu B, Wang Y, Fillgrove KL, Anderson VE. 2002. Triclosan inhibits enoyl-reductase of type I fatty acid synthase in vitro and is cytotoxic to MCF-7 and SKBr-3 breast cancer cells. Cancer Chemother Pharmacol. 49: 187–193.
  • Lu S, Archer MC. 2005. Fatty acid synthase is a potential molecular target for the chemoprevention of breast cancer. Carcinogenesis. 26: 153–157.
  • Ma H, Zheng L, Li Y, Pan S, Hu J, Yu Z, Zhang G, Sheng G, Fu J. 2013. Triclosan reduces the levels of global DNA methylation in HepG2 cells. Chemosphere. 90: 1023–1029.
  • Magi S, Castaldo P, Macrì ML, Maiolino M, Matteucci A, Bastioli G, Gratteri S, Amoroso S, Lariccia V. 2016. Intracellular calcium dysregulation: Implications for Alzheimer’s disease. Biomed Res Int. 2016: 6701324.
  • Matozzo V, Costa Devoti A, Marin MG. 2012. Immunotoxic effects of triclosan in the clam Ruditapes philippinarum. Ecotoxicology. 21: 66–74.
  • Marin IA, Kipnis J. 2017. Central nervous system: (immunological) ivory tower or not? Neuropsychopharmacology. 42: 28–35.
  • Marlatt VL, Veldhoen N, Lo BP, Bakker D, Rehaume V, Vallée K, Haberl M, Shang D, van Aggelen GC, Skirrow RC, Elphick JR, Helbing CC. 2013. Triclosan exposure alters postembryonic development in a Pacific tree frog (Pseudacris regilla) amphibian metamorphosis assay (TREEMA). Aquat Toxicol. 126: 85–94.
  • McMurry LM, Oethinger M, Levy SB. 1998. Triclosan targets lipid synthesis. Nature. 394: 531–532.
  • Moss T, Howes D, Williams FM. 2000. Percutaneous penetration and dermal metabolism of triclosan (2,4, 4’-trichloro-2’-hydroxydiphenyl ether). Food Chem Toxicol. 38: 361–370.
  • Movahed E, Tan GM, Munusamy K, Yeow TC, Tay ST, Wong WF, Looi CY. 2016. Triclosan demonstrates synergic effect with amphotericin B and fluconazole and induces apoptosis-like cell death in Cryptococcus neoformans. Front Microbiol. 7: 360.
  • Muth-Köhne E, Wichmann A, Delov V, Fenske M. 2012. The classification of motor neuron defects in the zebrafish embryo toxicity test (ZFET) as an animal alternative approach to assess developmental neurotoxicity. Neurotoxicol Teratol. 34:413–424.
  • Newton AP, Cadena SM, Rocha ME, Carnieri EG, Martinelli de Oliveira MB. 2005. Effect of triclosan (TRN) on energy-linked functions of rat liver mitochondria. Toxicol Lett. 160: 49–59.
  • Oliveira R, Domingues I, Koppe Grisolia C, Soares AM. 2009. Effects of triclosan on zebrafish early-life stages and adults. Environ Sci Pollut Res Int. 16: 679–688.
  • Orrenius S, Gogvadze V, Zhivotovsky B. 2015. Calcium and mitochondria in the regulation of cell death. Biochem Biophys Res Commun. 460: 72–81.
  • Parrott JL, Bennie DT. 2009. Life-cycle exposure of fathead minnows to a mixture of six common pharmaceuticals and triclosan. J Toxicol Environ Health A. 72: 633–641.
  • Paul KB, Hedge JM, Bansal RR, Zoeller T, Peter R, DeVito MJ, Crofton KM. 2012. Developmental triclosan exposure decreases maternal, fetal, and early neonatal thyroxine: A dynamic and kinetic evaluation of a putative mode-of-action. Toxicology. 300: 31–45.
  • Paul KB, Hedge JM, DeVito MJ, Crofton KM. 2010a. Short-term exposure to triclosan decreases thyroxine in vivo via upregulation of hepatic catabolism in young Long-Evans rats. Toxicol Sci. 113: 367–379.
  • Paul KB, Hedge JM, DeVito MJ, Crofton KM. 2010b. Developmental triclosan exposure decreases maternal and neonatal thyroxine in rats. Environ Toxicol Chem. 29: 2840–2844.
  • Paul KB, Thompson JT, Simmons SO, Vanden Heuvel JP, Crofton KM. 2013. Evidence for triclosan-induced activation of human and rodent xenobiotic nuclear receptors. Toxicol In Vitro. 7: 2049–2060.
  • Pessah IN, Cherednichenko G, Lein PJ. 2010. Minding the calcium store: Ryanodine receptor activation as a convergent mechanism of PCB toxicity. Pharmacol Ther. 125: 260–285.
  • Philippat C, Botton J, Calafat AM, Ye X, Charles MA, Slama R. 2014. Prenatal exposure to phenols and growth in boys. Epidemiology. 25: 625–635.
  • Queckenberg C, Meins J, Wachall B, Doroshyenko O, Tomalik-Scharte D, Bastian B, Abdel-Tawab M, Fuhr U. 2010. Absorption, pharmacokinetics, and safety of triclosan after dermal administration. Antimicrob Agents Chemother. 54: 570–572.
  • Ransohoff RM. 2016. How neuroinflammation contributes to neurodegeneration. Science. 353: 777–783.
  • Reiss R, Lewis G, Griffin J. 2009. An ecological risk assessment for triclosan in the terrestrial environment. Environ Toxicol Chem. 28: 1546–1556.
  • Riva C, Cristoni S, Binelli A. 2012. Effects of triclosan in the fresh water mussel Dreissena polymorpha: A proteomic investigation. Aquat Toxicol. 118-119: 62–71.
  • Rodricks JV, Swenberg JA, Borzelleca JF, Maronpot RR, Shipp AM. 2010. Triclosan: A critical review of the experimental data and development of margins of safety for consumer products. Crit Rev Toxicol. 40: 422–484.
  • Rodriguez PEA, Sanchez MS. 2010. Maternal exposure to triclosan impairs thyroid homeostasis and female pubertal development in Wistar rat offspring. J Toxicol Environ Health A. 73: 1678–1688.
  • Rotroff DM, Wetmore BA, Dix DJ, Ferguson SS, Clewell HJ, Houck KA, Lecluyse EL, Andersen ME, Judson RS, Smith CM, Sochaski MA, Kavlock RJ, Boellmann F, Martin MT, Reif DM, Wambaugh JF, Thomas RS. 2010. Incorporating human dosimetry and exposure into high-throughput in vitro toxicity screening. Toxicol Sci. 117: 348–358.
  • Rovet JF. 2014. The role of thyroid hormones for brain development and cognitive function. Endocr Dev. 26: 26–43.
  • Ruszkiewicz J, Albrecht J. 2015. Changes in the mitochondrial antioxidant systems in neurodegenerative diseases and acute brain disorders. Neurochem Int. 88: 66–72.
  • Sadowski MC, Pouwer RH, Gunter JH, Lubik AA, Quinn RJ, Nelson CC. 2014. The fatty acid synthase inhibitor triclosan: Repurposing an antimicrobial agent for targeting prostate cancer. Oncotarget. 5: 9362–9381.
  • Sandborgh-Englund G, Adolfsson-Erici M, Odham G, Ekstrand J. 2006. Pharmacokinetics of triclosan following oral ingestion in humans. J Toxicol Environ Health A. 69: 1861–1873.
  • Savage JH, Johns CB, Hauser R, Litonjua AA. 2014. Urinary triclosan levels and recent asthma exacerbations. Ann Allergy Asthma Immunol. 112: 179–181.
  • Savage JH, Matsui EC, Wood RA, Keet CA. 2012. Urinary levels of triclosan and parabens are associated with aeroallergen and food sensitization. J Allergy Clin Immunol. 130: 453–460.
  • Schuur AG, Legger FF, van Meeteren ME, Moonen MJ, van Leeuwen-Bol I, Bergman A, Visser TJ, Brouwer A. 1998. In vitro inhibition of thyroid hormone sulfation by hydroxylated metabolites of halogenated aromatic hydrocarbons. Chem Res Toxicol. 11: 1075–1081.
  • Sengupta N, Litoff EJ, Baldwin WS. 2015. The HR96 activator, atrazine, reduces sensitivity of D. magna to triclosan and DHA. Chemosphere. 128: 299–306.
  • Shim J, Weatherly LM, Luc RH, Dorman MT, Neilson A, Ng R, Kim CH, Millard PJ, Gosse JA. 2016. Triclosan is a mitochondrial uncoupler in live zebrafish. J Appl Toxicol. 36: 1662–1667.
  • Siddiqui AN, Siddiqui N, Khan RA, Kalam A, Jabir NR, Kamal MA, Firoz CK, Tabrez S. 2016. Neuroprotective role of steroidal sex hormones: An overview. CNS Neurosci Ther. 22: 342–350.
  • Singh SP, Azua A, Chaudhary A, Khan S, Willett KL, Gardinali PR. 2010. Occurrence and distribution of steroids, hormones and selected pharmaceuticals in South Florida coastal environments. Ecotoxicology, 19: 338–350.
  • Smaili SS, Hsu YT, Youle RJ, Russell JT. 2000. Mitochondria in Ca2+ signaling and apoptosis. J Bioenerg Biomembr. 32: 35–46.
  • Szychowski KA, Sitarz AM, Wojtowicz AK. 2015. Triclosan induces Fas receptor-dependent apoptosis in mouse neocortical neurons in vitro. Neuroscience. 284: 192–201.
  • Szychowski KA, Wnuk A, Kajta M, Wójtowicz AK. 2016. Triclosan activates aryl hydrocarbon receptor (AhR)-dependent apoptosis and affects Cyp1a1 and Cyp1b1 expression in mouse neocortical neurons. Environ Res. 151: 106–114.
  • Takeda A. 2001. Zinc homeostasis and functions of zinc in the brain. Biometals. 14: 343–351.
  • Takeda A, Tamano H. 2014. Cognitive decline due to excess synaptic Zn2+ signaling in the hippocampus. Front Aging Neurosci. 6: 26.
  • Tamura I, Kanbara Y, Saito M, Horimoto K, Satoh M, Yamamoto H, Oyama Y. 2012. Triclosan, an antibacterial agent, increases intracellular Zn2+ concentration in rat thymocytes: Its relation to oxidative stress. Chemosphere. 86: 70–75.
  • Tanoue R, Nomiyama K, Nakamura H, Hayashi T, Kim JW, Isobe T, Shinohara R, Tanabe S. 2014. Simultaneous determination of polar pharmaceuticals and personal care products in biological organs and tissues. J Chromatogr A. 1355: 193–205.
  • Tramutola A, Lanzillotta C, Perluigi M, Butterfield DA. 2016. Oxidative stress, protein modification and Alzheimer disease. Brain Res Bull. DOI: S0361-9230(16)30129-0.
  • Udoji F, Martin T, Etherton R, Whalen MM. 2010. Immunosuppressive effects of triclosan, nonylphenol, and DDT on human natural killer cells in vitro. J Immunotoxicol. 7: 205–212.
  • Vandhana S, Coral K, Jayanthi U, Deepa PR, Krishnakumar S. 2013. Biochemical changes accompanying apoptotic cell death in retinoblastoma cancer cells treated with lipogenic enzyme inhibitors. Biochim Biophys Acta. 1831: 1458–1466.
  • Veena SR, Krishnaveni GV, Wills AK, Kurpad AV, Muthayya S, Hill JC, Karat SC, Nagarajaiah KK, Fall CH, Srinivasan K. 2010. Association of birthweight and head circumference at birth to cognitive performance in 9- to 10-year-old children in South India: prospective birth cohort study. Pediatr Res. 67: 424–429.
  • Veldhoen N, Skirrow RC, Osachoff H, Wigmore H, Clapson DJ, Gunderson MP, Van Aggelen G, Helbing CC. 2006. The bactericidal agent triclosan modulates thyroid hormone-associated gene expression and disrupts postembryonic anuran development. Aquat Toxicol. 80: 217–227.
  • Wang X, Liu Z, Wang W, Yan Z, Zhang C, Wang W, Chen L. 2014. Assessment of toxic effects of triclosan on the terrestrial snail (Achatina fulica). Chemosphere. 108: 225–230.
  • Wang CF, Tian Y. 2015. Reproductive endocrine-disrupting effects of triclosan: Population exposure, present evidence and potential mechanisms. Environ Pollut. 206: 195–201.
  • Wayman GA, Yang D, Bose DD, Lesiak A, Ledoux V, Bruun D, Pessah IN, Lein PJ. 2012. PCB-95 promotes dendritic growth via ryanodine receptor–dependent mechanisms. Environ Health Persp. 120: 997–1002.
  • Weatherly LM, Kennedy RH, Shim J, Gosse JA. 2013. A microplate assay to assess chemical effects on RBL-2H3 mast cell degranulation: Effects of triclosan without use of an organic solvent. J Vis Exp. 2013: e50671.
  • Weatherly LM, Shim J, Hashmi HN, Kennedy RH, Hess ST, Gosse JA. 2016. Antimicrobial agent triclosan is a proton ionophore uncoupler of mitochondria in living rat and human mast cells and in primary human keratinocytes. J Appl Toxicol. 36: 777–789.
  • Winitthana T, Lawanprasert S, Chanvorachote P. 2014. Triclosan potentiates epithelial-to-mesenchymal transition in anoikis-resistant human lung cancer cells. PLoS One. 9: e110851.
  • Wilson B, Chen RF, Cantwell M, Gontz A, Zhu J, Olsen CR. 2009. The partitioning of triclosan between aqueous and particulate bound phases in the Hudson River Estuary. Mar Pollut Bull. 59: 207–212.
  • Witorsch RJ. 2014. Critical analysis of endocrine disruptive activity of triclosan and its relevance to human exposure through the use of personal care products. Crit Rev Toxicol. 44: 535–555.
  • Yueh MF, Taniguchi K, Chen S, Evans RM, Hammock BD, Karin M, Tukey RH. 2014. The commonly used antimicrobial additive triclosan is a liver tumor promoter. Proc Nat Acad Sci USA. 111: 17200–17205.
  • Zhang N, Wang W, Li W, Liu C, Chen Y, Yang Q, Wang Y, Sun K. 2015. Inhibition of 11β-HSD2 expression by triclosan via induction of apoptosis in human placental syncytiotrophoblasts. J Clin Endocrinol Metab. 100: E542–E549.
  • Zorrilla LM, Gibson EK, Jeffay SC, Crofton KM, Setzer WR, Cooper RL, Stoker TE. 2009. The effects of triclosan on puberty and thyroid hormones in male Wistar rats. Toxicol Sci. 107: 56–64.
  • Zuckerbraun HL, Babich H, May R, Sinensky MC. 1998. Triclosan: Cytotoxicity, mode of action, and induction of apoptosis in human gingival cells in vitro. Eur J Oral Sci. 106:628–636.

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