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Original Articles

Quantitative weight of evidence assessment of higher tier studies on the toxicity and risks of neonicotinoids in honeybees. 4. Thiamethoxam

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References

  • [NWQMC] National Water Quality Monitoring Council. 2016. Water quality data. NWQMC. Accessed January, 2016. http://waterqualitydata.us/portal/.
  • [OMECC] Ontario Ministry of Environment and Climate Change. 2017. Stream neonicotinoid monitoring study OMECC. Accessed January 25, 2017. https://www.ontario.ca/search/data-catalogue?sort=asc&query=Neonicotinoid.
  • [PubChem] PubChem. 2016. Clothianidin. PubChem. Accessed April, 2016. http://pubchem.ncbi.nlm.nih.gov/compound/Thiamethoxam#section=Top.
  • Anderson, T. A., C. J. Salice, R. A. Erickson, S. T. McMurry, S. B. Cox, and L. M. Smith. 2013. Effects of landuse and precipitation on pesticides and water quality in playa lakes of the southern high plains. Chemosphere 92:84–90. doi:10.1016/j.chemosphere.2013.02.054.
  • Bargańska, Ż., M. Ślebioda, and J. Namieśnik. 2013. Pesticide residues levels in honey from apiaries located of Northern Poland. Food Control 31:196–201. doi:10.1016/j.foodcont.2012.09.049.
  • BCPC. 2015. The Pesticide Manual (12th ed.), ed. Tomlin, C. D. S., Alton, UK: British Crop Protection Council.
  • Biocca, M., R. Fanigliulo, P. Gallo, P. Pulcini, and D. Pochi. 2015. The assessment of dust drift from pneumatic drills using static tests and in-field validation. Crop Protect 71:109–15. doi:10.1016/j.cropro.2015.02.006.
  • Blacquière, T., G. Smagghe, C. A. M. Van Gestel, and V. Mommaerts. 2012. Neonicotinoids in bees: A review on concentrations, side-effects and risk assessment. Ecotoxicology 21:973–92. doi:10.1007/s10646-012-0863-x.
  • Botias, C., A. David, J. Horwood, A. Abdul-Sada, E. Nicholls, E. Hill, and D. Goulson. 2015. Neonicotinoid residues in wildflowers, a potential route of chronic exposure for bees. Environmental Science & Technology 49:12731–40. doi:10.1021/acs.est.5b03459.
  • Codling, G., Y. Al Naggar, J. P. Giesy, and A. J. Robertson. 2016. Concentrations of neonicotinoid insecticides in honey, pollen and honey bees (Apis mellifera L.) in central Saskatchewan, Canada. Chemosphere 144:2321–28. doi:http://dx.doi.org/10.1016/j.chemosphere.2015.10.13.
  • David, A., C. Botías, A. Abdul-Sada, E. Nicholls, E. L. Rotheray, E. M. Hill, and D. Goulson. 2016. Widespread contamination of wildflower and bee-collected pollen with complex mixtures of neonicotinoids and fungicides commonly applied to crops. Environment International 88:169–78. doi:10.1016/j.envint.2015.12.011.
  • Di Prisco, G., V. Cavaliere, D. Annoscia, P. Varricchio, E. Caprio, F. Nazzi, G. Gargiulo, and F. Pennacchio. 2013. Neonicotinoid clothianidin adversely affects insect immunity and promotes replication of a viral pathogen in honey bees. Proceedings of the National Academy of Sciences USA 110:18466–71. doi:10.1073/pnas.1314923110.
  • Dively, G. P., and A. Kamel. 2012. Insecticide residues in pollen and nectar of a cucurbit crop and their potential exposure to pollinators. Journal of Agricultural and Food Chemistry 60:4449–56. doi:10.1021/jf205393x.
  • EFSA. 2014. Conclusion on the peer review of the pesticide risk assessment for bees for the active substance thiamethoxam. EFSA Journal 11:3067. doi:10.2903/j.efsa.2013.3067.
  • EPPO. 1992. Guideline on test methods for evaluating the side-effects of plant protection products on honey bees. EPPO Bulletin 22:203–08.
  • Henry, M., N. Cerrutti, P. Aupinel, A. Decourtye, M. Gayrard, J.-F. Odoux, A. Pissard, C. Rüger, and V. Bretagnolle. 2015. Reconciling laboratory and field assessments of neonicotinoid toxicity to honeybees. Proceedings of the National Academy of Sciences 282:2015–110. doi:10.1098/rspb.2015.2110.
  • Hilton, M. J., T. D. Jarvis, and D. C. Ricketts. 2016. The degradation rate of thiamethoxam in European field studies. Pest Management Science 72:388–97. doi:10.1002/ps.4024.
  • Hladik, M. L., and D. W. Kolpin. 2016. First national-scale reconnaissance of neonicotinoid insecticides in streams across the USA. Environmental Chemistry 13:12–20. doi:http://dx.doi.org/10.1071/EN15061.
  • Hladik, M. L., M. Vandever, and K. L. Smalling. 2016. Exposure of native bees foraging in an agricultural landscape to current-use pesticides. Science of the Total Environment 542 (Part A):469–77. doi:10.1016/j.scitotenv.2015.10.077.
  • Jeschke, P., R. Nauen, M. Schindler, and A. Elbert. 2011. Overview of the status and global strategy for neonicotinoids. Journal of Agricultural and Food Chemistry 59:2897–908.doi:10.1021/jf101303g.
  • Jones, A., and G. Turnbull. 2016. Neonicotinoid concentrations in UK honey from 2013. Pest Management Science 72:1897–900. doi:10.1002/ps.4227.
  • Kasiotis, K. M., C. Anagnostopoulos, P. Anastasiadou, and K. Machera. 2014. Pesticide residues in honeybees, honey and bee pollen by LC-MS/MS screening: Reported death incidents in honeybees. Science of the Total Environment 485-486:633–42. doi:10.1016/j.scitotenv.2014.03.042.
  • Krupke, C. H., G. J. Hunt, B. D. Eitzer, G. Andino, and K. Given. 2012. Multiple routes of pesticide exposure for honey bees living near agricultural fields. PLoS ONE 7:e29268. doi:10.1371/journal.pone.0029268.
  • Lawrence, T. J., E. M. Culbert, A. S. Felsot, V. R. Hebert, and W. S. Sheppard. 2016. Survey and risk assessment of Apis mellifera (Hymenoptera: Apidae) exposure to neonicotinoid pesticides in urban, rural, and agricultural settings. Journal of Economic Entomology 109:520–28. doi:10.1093/jee/tov397.
  • Main, A. R., J. Fehr, K. Liber, J. V. Headley, K. M. Peru, and C. A. Morrissey. 2017. Reduction of neonicotinoid insecticide residues in Prairie wetlands by common wetland plants. Science of the Total Environment 579:1193–202. doi:10.1016/j.scitotenv.2016.11.102.
  • Main, A. R., J. V. Headley, K. M. Peru, N. L. Michel, A. J. Cessna, and C. A. Morrissey. 2014. Widespread use and frequent detection of neonicotinoid insecticides in wetlands of Canada’s Prairie Pothole Region. PLoS ONE 9:e92821. doi:10.1371/journal.pone.0092821.
  • Main, A. R., N. L. Michel, M. C. Cavallaro, J. V. Headley, K. M. Peru, and C. A. Morrissey. 2016. Snowmelt transport of neonicotinoid insecticides to Canadian Prairie wetlands. Agriculture, Ecosystems & Environment 215:76–84. doi:10.1016/j.agee.2015.09.011.
  • Mullin, C. A., M. Frazier, J. L. Frazier, S. Ashcraft, R. Simonds, D. Vanengelsdorp, and J. S. Pettis. 2010. High levels of miticides and agrochemicals in North American apiaries: Implications for honey bee health. PLoS ONE 5:e9754. doi:10.1371/journal.pone.0009754.
  • Pacífico Da Silva, I., F. A. S. Oliveira, H. P. Pedroza, I. C. N. Gadelha, M. M. Melo, and B. Soto-Blanco. 2015. Pesticide exposure of honeybees (Apis mellifera) pollinating melon crops. Apidologie 46:703–15. doi:10.1007/s13592-015-0360-3.
  • Pilling, E., P. Campbell, M. Coulson, N. Ruddle, and I. Tornier. 2013. A four-year field program investigating long-term effects of repeated exposure of honey bee colonies to flowering crops treated with thiamethoxam. PLoS ONE 8:e77193. doi:10.1371/journal.pone.0077193.
  • Pohorecka, K., P. Skubida, A. Miszczak, P. Semkiw, P. Sikorski, K. Zagibajło, D. Teper, Z. Kołtowski, M. Skubida, D. Zdańska, and A. Bober. 2012. Residues of neonicotinoid insecticides in bee collected plant materials from oilseed rape crops and their effect on bee colonies. Journal of Apicultural Science 56. doi:10.2478/v10289-012-0029-3.
  • Sanchez-Hernandez, L., D. Hernandez-Dominguez, M. T. Martin, M. J. Nozal, M. Higes, and J. L. Bernal Yague. 2016. Residues of neonicotinoids and their metabolites in honey and pollen from sunflower and maize seed dressing crops. Journal of Chromatography 1428:220–7. doi:10.1016/j.chroma.2015.10.066.
  • Schaafsma, A., V. Limay-Rios, T. Baute, J. Smith, and Y. Xue. 2015. Neonicotinoid insecticide residues in surface water and soil associated with commercial maize (corn) fields in Southwestern Ontario. PLoS ONE 10:e0118139. doi:10.1371/journal.pone.0118139.
  • Schneider, C. W., J. Tautz, B. Grunewald, and S. Fuchs. 2012. RFID tracking of sublethal effects of two neonicotinoid insecticides on the foraging behavior of Apis mellifera. PLoS ONE 7:e30023. doi:10.1371/journal.pone.0030023.
  • SETAC, editor. 1995. Procedures for Assessing the Environmental Fate and Ecotoxicity of Pesticides. Pensacola, Florida: SETAC.
  • Solomon, K. R., and G. L. Stephenson. 2017a. Quantitative weight of evidence assessment of higher tier studies on the toxicity and risks of neonicotinoid insecticides in honeybees 1: Methods. Journal Toxicogical Environment Health B. This issue.
  • Solomon, K. R., and G. L. Stephenson. 2017b. Quantitative weight of evidence assessment of higher tier studies on the toxicity and risks of neonicotinoid insecticides in honeybees 3: Clothianidin. Journal Toxicogical Environment Health B. This issue.
  • Stanley, J., K. Sah, S. K. Jain, J. C. Bhatt, and S. N. Sushil. 2015. Evaluation of pesticide toxicity at their field recommended doses to honeybees, Apis cerana and A. mellifera through laboratory, semi-field and field studies. Chemosphere 119:668–74. doi:10.1016/j.chemosphere.2014.07.039.
  • Stephenson, G. L., and K. R. Solomon. 2017. Quantitative weight of evidence assessment of higher tier studies on the toxicity and risks of neonicotinoid insecticides in honeybees 2: Imidacloprid. Journal Toxicogical Environment Health B. This issue.
  • Stewart, S. D., G. M. Lorenz, A. L. Catchot, J. Gore, D. Cook, J. Skinner, T. C. Mueller, D. R. Johnson, J. Zawislak, and J. Barber. 2014. Potential exposure of pollinators to neonicotinoid insecticides from the use of insecticide seed treatments in the Mid-Southern United States. Environmental Science & Technology 48:9762–69. doi:10.1021/es501657w.
  • Stoner, K. A., and B. D. Eitzer. 2012. Movement of soil-applied imidacloprid and thiamethoxam into nectar and pollen of squash (Cucurbita pepo). PLoS ONE 7:e39114. doi:10.1371/journal.pone.0039114.
  • Struger, J., J. Grabuski, S. Cagampan, E. Sverko, D. McGoldrick, and C. H. Marvin. 2017. Factors influencing the occurrence and distribution of neonicotinoid insecticides in surface waters of southern Ontario, Canada. Chemosphere 169:516–23. doi:10.1016/j.chemosphere.2016.11.036.
  • Syngenta. 1998a. Tunnel test: Effects of sunflowers grown from seeds dressed with A-9567B on Honey Bees (Apis mellifera). (Unpublished Report). Report CGA293343_0957 - A9567B (S98NCR3769V074), Syngenta Ltd, Basel, Switzerland.
  • Syngenta. 1998b. Semi-field test: Effects of oil-seed winter-rape grown from seeds dressed with A9700 B on the Honey Bee (Apis mellifera L.). (Unpublished Report). Report CGA293343_0822 - A9700B, Syngenta Ltd, Basel, Switzerland.
  • Syngenta. 1999. BeeSCAN monitoring in summer rape grown from seed dressed with Cruiser A 9567 B. (Unpublished Report). Report CGA293343_1351 - A9567B, Syngenta Ltd, Munchwilen, Switzerland.
  • Syngenta. 2000a. Report on analytical study 100/99 determination of analytes thiamethoxam (CGA 293343) and CGA 322704 in honey and sun flower heads collected in study 983769. (Unpublished Report). Report CGA293343_1363 - A9567B, Syngenta Ltd, Basel, Switzerland.
  • Syngenta. 2000b. Two field trials to determine the effects of HELIXTM seed treatment on honeybees foraging on canola flowers. (Unpublished Report). Report CGA293343_1384 - A11642A (CER03214/99), Syngenta Ltd, Guelph, Canada.
  • Syngenta. 2000c. Report on analytical study 107/00 determination of analytes thiamethoxam (CGA 293343) and CGA 322704 in sun flower (Heads and flowers), honey, nectar, and pollen collected in study 31062/00. (Unpublished Report). Report CGA293343_1365 - A9567B, Syngenta Ltd, Basel, Switzerland.
  • Syngenta. 2000d. Report on analytical study 107/00 determination of analytes thiamethoxam (CGA 293343) and CGA 322704 in sun flower (Heads), honey, and pollen collected in study S99NCB1556V046 (Unpublished Report). Report CGA293343_1366 - A9567B, Syngenta Ltd, Basel, Switzerland.
  • Syngenta. 2000e. Report on analytical study 106/00 determination of analytes thiamethoxam (CGA 293343) and CGA 322704 in sun flower (Heads and flowers), honey, nectar, and pollen collected in study 31061/00. (Unpublished Report). Report CGA293343_1364 - A9567B, Syngenta Ltd, Basel, Switzerland.
  • Syngenta. 2000f. Report on analytical study 104/00 determination of analytes thiamethoxam (CGA 293343) and CGA 322704 in sun flower (Heads and leafs), honey, pollen, and bee (Honey stomach content) collected in study 99332/S1-BFEU. (Unpublished Report). Report CGA293343_1367 - A9567B, Syngenta Ltd, Basel, Switzerland.
  • Syngenta. 2000g. Tunnel test- effects of sunflowers grown from seeds dressed with CGA 293343 70 WS (A-9567 B) on Honey Bees (Apis mellifera). (Unpublished Report). Report CGA293343_1408 - A9567B (S99NCB1556VO46), Syngenta Ltd, Basel, Switzerland.
  • Syngenta. 2001a. Field test: effects of oil-seed spring-rape grown from seeds dressed with CGA 293343 WS 70 (A 9567 B) on the Honey Bee (Apis mellifera L.) (Conducted in Southern Germany near Pforzheim). (Unpublished Report). Report CGA293343_1376 - A9567B (99125/01-BFEU), Syngenta Ltd, Basel, Switzerland.
  • Syngenta. 2001b. Report on analytical study 103/01 determination of analytes thiamethoxam (CGA 293343) and CGA 322704 in sunflowers (Flowers, leaves), honey, honey stomach content, and pollen, collected in study 20001072/I1-BFEU. (Unpublished Report). Report CGA293343_1411- A9567B, Syngenta Ltd., Basel, Switzerland.
  • Syngenta. 2001c. Report on analytical study 102/01 determination of analytes thiamethoxam (CGA 293343) and CGA 322704 in winter rape (Leaves, blossoms), honey, honey stomach content, and pollen, collected in study 99393/01-BFEU. (Unpublished Report). Report CGA293343_1830, Syngenta Ltd, Basel, Switzerland.
  • Syngenta. 2001d. Report on analytical study 112/01 determination of analytes thiamethoxam (CGA 293343) and CGA 322704 in oil seed rape (Flowers), honey, honey stomach content, and pollen, collected in study 00 10 48 016. (Unpublished Report). Report CGA293343_1832, Syngenta Ltd, Basel, Switzerland.
  • Syngenta. 2001e. Semi-field test: Side effects of oil-seed spring-rape (Brassica napus) dressed with different rates of CGA 293343 on the Honey Bee (Apis mellifera L.). (Unpublished Report). Report CGA293343_1833 - A9807C, A9567C (20001077/01-BZEU). Syngenta Ltd., Basel, Switzerland.
  • Syngenta. 2001f. Field test: Side effects of sunflower grown from seeds dressed with A-9567 B on the Honey Bee (Apis mellifera L.) in Italy. (Unpublished Report). Report CGA293343_1391 - A9567B (20001072/I1-BFEU). Syngenta Ltd., Basel, Switzerland.
  • Syngenta. 2001g. Assessment of side effects of CGA 293343 + CGA 329351 + CGA 173506 FS 321.3 (A 9807 C) applied as seed dressing of Brassica napus on the Honeybee Apis mellifera L. (Unpublished Report). Report CGA173506_5395 - A9807C (2003626), Syngenta Ltd, Basel, Switzerland.
  • Syngenta. 2001h. Field test: Side effects of oil-seed winter-rape grown from seeds dressed with Cruiser OSR (A9807 C) on the Honey Bee (Apis mellifera L.). (Unpublished Report). Report CGA173506_5423 - A9807C (99393/01-BFEU), Syngenta Ltd, Basel, Switzerland.
  • Syngenta. 2001i. Field test (Non-GLP): Side effects of oil-seed winter-rape grown from seeds dressed with A9807 C on the Honey Bee (Apis mellifera L.). (Unpublished Report). Report CGA173506_5452 - A9807C (991579), Syngenta Ltd, Basel, Switzerland.
  • Syngenta. 2001j. Field test: effects of oil-seed spring-rape grown from seeds dressed with CGA 293343 WS 70 (A 9567 B) on the Honey Bee (Apis mellifera L.) (Conducted in Northern Germany near Celle). (Unpublished Report). Report CGA293343_1360 - A9567B (99125/02-BFEU), Syngenta Ltd, Basel, Switzerland.
  • Syngenta. 2001k. Field test: Side effects of sunflowers grown from seeds dressed with CGA 293343 WS 70 (A 9567 B) on the Honey Bee (Apis mellifera L.) in Spain. (Unpublished Report). Report CGA293343_1361 - A9567B (99332/S1-BFEU), Syngenta Ltd, Basel, Switzerland.
  • Syngenta. 2001l. Field test: Side effects of sunflowers grown from seeds dressed with CGA 293343 350 FS (A-9700 B) on the Honeybee (Apis mellifera carnica). (Unpublished Report). Report CGA293343_1369 - A9700B (31061/00), Syngenta Ltd, Basel, Switzerland.
  • Syngenta. 2001m. Field test: Side effects of sunflowers grown from seeds dressed with CGA 293343 350 FS (A-9700 B) on the Honeybee (Apis mellifera carnica). (Unpublished Report). Report CGA293343_1370 - A9700B (31062/00), Syngenta Ltd, Basel, Switzerland.
  • Syngenta. 2001n. Semi-field test (Tunnel): Side effects of sunflower grown from seeds dressed with A-9567 B on the Honey Bee (Apis mellifera) in Spain. (Unpublished Report). Report CGA293343_1375 - A9567B (20001072/S1-BZEU), Syngenta Ltd, Basel, Switzerland.
  • Syngenta. 2002. Determination of residues of thiamethoxam (CGA 293343) and CGA 322704 in Maize plants and Maize pollen after seed dressing with A9567C. (Unpublished Report). Report CGA293343_1643, Syngenta Ltd, Bracknell, Berkshire, United Kingdom.
  • Syngenta. 2003a. Determination of analytes thiamethoxam (CGA 293343) and Its Metabolite CGA 322704 in or on Pollen, Nectar and Honey from sunflower collected in study 991567. (Unpublished Report). Report CGA293343_1704, Syngenta Ltd, Basel, Switzerland.
  • Syngenta. 2003b. Field test: Side effects of sunflower grown from seeds dressed with A-9700 B on Honey Bee (Apis mellifera L.) in Argentina. (Unpublished Report). Report CGA293343_1697 - A9700B (991567), Syngenta Ltd, Basel, Switzerland.
  • Syngenta. 2007a. Thiamethoxam (CGA293343) and its Metabolite (CGA322704): A residue study with A10590C treated maize seed, investigating residues in crop, soil and honeybee products in Alsace, France. (Unpublished Report). Report CGA173506_7323 - A10590C (20051149/F1-BZEU), Syngenta Ltd, Bracknell, Berkshire, United Kingdom.
  • Syngenta. 2007b. Thiamethoxam (CGA293343) and its Metabolite (CGA322704): A residue study with A9700B treated spring barley seed followed by A9807C treated winter oil-seed rape seed, investigating residues in crop and honeybee products in Northern France. (Unpublished Report). Report A9700B_10673 A9807C, Bracknell Berkshire, United Kingdom, Syngenta Ltd.
  • Syngenta. 2007c. Thiamethoxam (CGA293343) and its metabolite (CGA322704): A residue study with A9807C treated winter oil-seed rape seed, investigating residues in crop and honeybee products in Alsace (France). (Unpublished Report). Report CGA173506_7186 A9807C, Syngenta Ltd, Bracknell, Berkshire, United Kingdom.
  • Syngenta. 2007d. Thiamethoxam (CGA293343) and its metabolite (CGA322704): A residue study with A9807C treated winter oil-seed rape seed, investigating residues in crop and honeybee products in Southern France. (Unpublished Report). Report CGA173506_7188 A9807C, Syngenta Ltd, Bracknell, Berkshire, United Kingdom.
  • Syngenta. 2007e. Thiamethoxam: Deposition of dust from pneumatic drilling of A10590C treated maize seed in France during 2006. (Unpublished Report). Report CGA293343_3445, Syngenta Ltd, Bracknell, Berkshire, United Kingdom.
  • Syngenta. 2007f. Thiamethoxam (CGA293343) and its Metabolite (CGA322704): A residue study with A10590C treated maize seed, investigating residues in crop, soil and honeybee products in Southern France. (Unpublished Report). Report CGA173506_7324 - A10590C (20051149/F2-BZEU), Syngenta Ltd, Bracknell, Berkshire, United Kingdom.
  • Syngenta. 2007g. Thiamethoxam (CGA293343) and its Metabolite (CGA322704): A residue study with A10590C treated maize seed, investigating residues in crop, soil and honeybee products in northern France. (Unpublished Report). Report CGA173506_7333 - A10590C (2032750), Syngenta Ltd, Bracknell, Berkshire, United Kingdom.
  • Syngenta. 2007h. Thiamethoxam (CGA293343) and its metabolite (CGA322704): A residue study with A9700B treated spring barley seed followed by A9807C treated winter oil-seed rape seed, investigating residues in crop, soil and honeybee products in Southern France. (Unpublished Report). Report CGA293343_ 3436 A9700B, A9807C (20051040/F2-BZEU), Syngenta Ltd, Bracknell, Berkshire, United Kingdom.
  • Syngenta. 2007i. Thiamethoxam (CGA 293343) and its Metabolite (CGA322704): A residue study with A9700B treated spring barley seed followed by A9807C treated winter oilseed rape seed, investigating residues in crop, soil and honeybee products in Northern France. (Unpublished Report). Report CGA293343-3456 A9700B, A9807C (2032738), Syngenta Ltd, Bracknell, Berkshire, United Kingdom.
  • Syngenta. 2007j. Thiamethoxam (CGA 293343) and its Metabolite (CGA322704): A residue study with A9807C treated winter oilseed rape seed, investigating residues in crop and honeybee products in Northern France. (Unpublished Report). Report CGA1730506 _7187 A9807C (20051041/F2-BZEU), Syngenta Ltd, Bracknell, Berkshire, United Kingdom.
  • Syngenta. 2008a. Thiamethoxam; deposition of dust from Pneumatic DRILLING of A9700B treated maize seed in France during 2005. (Unpublished Report). Report A9700B_10842, Syngenta Ltd, Bracknell, Berkshire, United Kingdom.
  • Syngenta. 2008b. Thiamethoxam: Deposition of dust from Pneumatic drilling of A9700B+A9638A treated maize seed in France during 2008. (Unpublished Report). Report A9700B, Syngenta Ltd, Bracknell, Berkshire, United Kingdom.
  • Syngenta. 2009a. Thiamethoxam (CGA293343): A field study with A9807C treated winter oilseed rape seed, investigating effects on Honeybees (Apis mellifera L.) over Four Years in Alsace (France). (Unpublished Report). Report A9807C_10957 (20051041/F1-BFEU), Syngenta Ltd, Bracknell, Berkshire, United Kingdom.
  • Syngenta. 2009b. Thiamethoxam (CGA293343): A field study with A9807C treated winter oilseed rape seed, investigating effects on Honeybees (Apis mellifera L.) over Four years in Northern France. (Unpublished Report). Report A9807C_10958 - A9807C (20051041/F2-BFEU), Syngenta Ltd, Bracknell, Berkshire, United Kingdom.
  • Syngenta. 2010a. Thiamethoxam (A9700B, A9584C) - A semi-field study with dust from A9700B treated Maize seeds and A9584C to evaluate effects on the Honeybee Apis mellifera L. (Hymenoptera, Apidae) in Phacelia tanacetifolia. (Unpublished Report). Report A9700B_10908 - A9700B, A9584C, Syngenta Ltd, Bracknell, Berkshire, United Kingdom.
  • Syngenta. 2010b. Thiamethoxam (CGA293343) - A semi-field study with A9700B + A9638A treated Maize seed, followed by untreated flowering crop(s), investigating residues in crop(s), soil and honeybee products in burgundy (France), in 2009. (Unpublished Report). Report A9700B_10916 - A9700B (S08-01285), Syngenta Ltd, Bracknell, Berkshire, United Kingdom.
  • Syngenta. 2010c. Thiamethoxam (CGA293343) - A field study with A9700B + A9638A treated Maize seed, investigating effects on Honeybees (Apis mellifera L.) over Four years in Alsace (France). (Unpublished Report). Report A9700B_10911 - A9700B (20061138/F1-BFEU), Syngenta Ltd, Bracknell, Berkshire, United Kingdom.
  • Syngenta. 2010d. Thiamethoxam (CGA293343) - A field study with A9700B + A9638A treated maize seed, investigating effects on Honeybees (Apis mellifera L.) over Four Years in Lorraine (France). (Unpublished Report). Report A9700B_10912 - A9700B (20061138/F2-BFEU), Syngenta Ltd, Bracknell, Berkshire, United Kingdom.
  • Syngenta. 2010e. Thiamethoxam – Investigating the deposition of dust from Pneumatic drilling of A9700B treated maize seeds in Italy during 2009. (Unpublished Report). Report CGA293343_11508-A9700BS, Syngenta Ltd, Bracknell, Berkshire, United Kingdom.
  • Syngenta. 2010f. Thiamethoxam - Investigating the deposition of dust from Pneumatic drilling of A9700B treated Maize seeds in France during 2009. (Unpublished Report). Report A9700B_10917, Syngenta Ltd, Bracknell, Berkshire, United Kingdom.
  • Syngenta. 2010g. Evaluation of deposition of seed treatment particles abraded from “PRODUCT” dressed maize seeds emitted during sowing, in adjacent oilseed rape and bare soil areas Final Report Amendment No. 1. (Unpublished Report). Report A9700B_10906, Syngenta Ltd, Frankfurt am Main, Germany.
  • Syngenta. 2010h. Thiamethoxam (CGA293343) - A field study with A9700B + A9638A treated maize seed, investigating effects on Honeybees (Apis mellifera L.) over Four years in Southern France. (Unpublished Report). Report A9700B_10913 - A9700B (20061138/F3-BFEU), Syngenta Ltd, Bracknell, Berkshire, United Kingdom.
  • Syngenta. 2010i. Thiamethoxam FS (A9700B) - A field study with treated maize seeds, investigating the effects of residues from dust during seeding and residues in guttation liquid, on Honeybee Colonies in Alsace (France) in 2009. (Unpublished Report). Report A9700B_10921 - A9700B (S09-01639), Syngenta Ltd, Bracknell, Berkshire, United Kingdom.
  • Syngenta. 2010j. Thiamethoxam (CGA293343) - A semi-field study with A9700B + A9638A treated maize seed, followed by untreated flowering crop(s), investigating residues in crop(s), Soil and Honeybee products in Alsace (France), in 2009. (Unpublished Report). Report A9700B_10915 - A9700B (S08-01279), Syngenta Ltd, Bracknell, Berkshire, United Kingdom.
  • Syngenta. 2010k. Thiamethoxam (CGA293343) - A semi-field study with A9700B + A9638A treated maize seed, followed by untreated flowering crop(s), investigating residues in crop(s), Soil and Honeybee products in Picardie (France), in 2009. (Unpublished Report). Report A9700B_10914 - A9700B (S08-01284), Syngenta Ltd, Bracknell, Berkshire, United Kingdom.
  • Syngenta. 2010l. Thiamethoxam - A semi-field study with maize seeds treated with A9700B and A14304E, Investigating residues in guttation liquid in 2009. (Unpublished Report). Report A9700B_10918 - A9700B, A14304E (S09-02828), Syngenta Ltd, Bracknell, Berkshire, United Kingdom.
  • Syngenta. 2011a. Investigating the dust deposition during sowing of seed-treated oilseed rape seeds with air assisted (Pneumatic) sowing machinery. (Unpublished Report). Report A9807C_10978 - CWFG - A9807C, Syngenta Ltd, Frankfurt am Main, Germany.
  • Syngenta. 2011b. Determination of residues of thiamethoxam and its metabolites in sweet corn and sorghum pollen after drilling of seeds treated with A9700B, France 2010. (Unpublished Report). Report A9700B_10940 - A9700B (S10-01907), Syngenta Ltd, Bracknell, Berkshire, United Kingdom.
  • Syngenta. 2011c. Investigating the dust deposition during sowing of seed-treated oilseed rape seeds with air assisted (Pneumatic) sowing machinery. (Unpublished Report). Report A9807C_10977 - CWFG - A9807C, Syngenta Ltd, Frankfurt am Main, Germany.
  • Syngenta. 2012a. Thiamethoxam FS (A9700B) - A field study with treated maize seeds, investigating the effects of residues from dust during drilling, residues in guttation liquid and flowering maize, on the Honeybee (Apis mellifera L.) in Alsace, France in 2010. Final Report Amendment 1. (Unpublished Report). Report A9700B S10-01857, Syngenta Ltd, Bracknell, United Kingdom.
  • Syngenta. 2012b. Thiamethoxam FS (A9700B) - A field study with treated maize seeds, investigating the effects of residues from dust during drilling, residues in guttation liquid and flowering maize, on the Honeybee (Apis mellifera L.) in Lorraine (France) in 2010. Final Report Amendment 2. (Unpublished Report). Report A9700B S10-01859, Syngenta Ltd, Bracknell, United Kingdom.
  • Syngenta. 2012c. Thiamethoxam - Investigating the deposition of dust from Pneumatic drilling of A9700B treated sunflower seeds in Northern Germany during 2011. (Unpublished Report). Report A9700B_10950 - A9700B, Syngenta Ltd, Bracknell, Berkshire, United Kingdom.
  • Syngenta. 2012d. Thiamethoxam FS (A9700B) - A field study with treated maize seeds, investigating the effects of residues from dust during drilling, residues in guttation liquid and flowering maize, on the Honeybee (Apis mellifera L.) in Stade, Germany in 2010. Final Report Amendment 1. (Unpublished Report). Report A9700B-S10-01860, Syngenta Ltd, Bracknell, Berkshire, United Kingdom.
  • Syngenta. 2012e. Thiamethoxam and CGA322704 - A9807C - Monitoring of the deposition of thiamethoxam and CGA322704 dust emitted during sowing of oil-seed rape dressed with Cruiser OSR (Germany, 2008). (Unpublished Report). Report A9807C_10980 - A9807C, Syngenta Ltd, Maintal, Germany.
  • Syngenta. 2012f. Thiamethoxam FS (A9700B) - A field study with treated maize seeds, investigating the effects of residues from dust during drilling, residues in guttation liquid and flowering maize, on the Honeybee (Apis mellifera L.) in Stade, Germany in 2010. (Unpublished Report). Report A9700B_10951, Syngenta Ltd, Niefern-Öschelbronn, Germany.
  • Syngenta. 2012g. Thiamethoxam FS (A9700B) - A field study with treated maize seeds, investigating the effects of residues from dust during drilling, residues in guttation liquid and flowering maize, on the Honeybee (Apis mellifera L.) in Alsace, France in 2010. (Unpublished Report). Report A9700B_10952, Syngenta Ltd, Niefern-Öschelbronn, Germany.
  • Syngenta. 2012h. Thiamethoxam FS (A9700B) - A field study with treated maize seeds, investigating the effects of residues from dust during drilling, residues in guttation liquid and flowering maize, on the Honeybee (Apis mellifera L.) in Lorraine (France) in 2010. (Unpublished Report). Report A9700B_10953, Syngenta Ltd, Niefern-Öschelbronn, Germany.
  • Syngenta. 2013a. Thiamethoxam - monitoring of potential effects of the drilling of thiamethoxam FS treated maize seeds on honeybees, guttation monitoring of maize seedlings under agronomic use conditions and assessment of the relevance of guttation for Honeybees in Alsace (France). (Unpublished Report). Report CGA293343_11583 - A9807F (S10-01275), Syngenta Ltd.
  • Syngenta. 2013b. Thiamethoxam – A field study to evaluate the magnitude of residues of thiamethoxam and its metabolite CGA322704 in Melon following a granular application of Actara® 5GR (A12180A) at transplanting in Spain 2012 Final report. (Unpublished Report). Report A12180A_10000 - A12180A (S12-02311), Syngenta Ltd, Bracknell, Berkshire, United Kingdom.
  • Syngenta. 2014. Thiamethoxam/Difenoconazole/Metalaxyl-M/Fludioxonil FS (A11642A) – Residue Levels in or on Canola (Flowers, Pollen and Nectar) from Trials Conducted in Canada during 2012 and 2013 Final report. (Unpublished Report). Report A11642A (TK0116694), Syngenta Ltd, Guelph, Canada.
  • Syngenta. 2015. Thiamethoxam technical – Honey Bee brood and colony level effects following Thiamethoxam Intake via Treated Sucrose Solution in a Field Study in North Carolina. (Unpublished Report). Report S14-02633, Syngenta Ltd, Greensboro, United States.
  • Thompson, H., M. Coulson, N. Ruddle, S. Wilkins, and S. Harkin. 2016. Thiamethoxam: Assessing flight activity of honeybees foraging on treated oilseed rape using radio frequency identification technology. Environmental Toxicology and Chemistry 35:385–93. doi:10.1002/etc.3183.
  • USEPA. 2014. Guidance for Assessing Pesticide Risks to Bees. Washington, DC: Office of Chemical Safety and Pollution Prevention, Office of Pesticide Programs. United States Environmental Protection Agency. https://www.epa.gov/sites/production/files/2014-06/documents/pollinator_risk_assessment_guidance_06_19_14.pdf
  • Yamamoto, A., T. Terao, H. Hisatomi, H. Kawasaki, and R. Arakawa. 2012. Evaluation of river pollution of neonicotinoids in Osaka City (Japan) by LC/MS with dopant-assisted photoionisation. Journal of Environmental Monitoring 14:2189–94. doi:10.1039/c2em30296a.
  • Zhang, B., X. Pan, L. Venne, S. Dunnum, S. T. McMurry, G. P. Cobb, and T. A. Anderson. 2008. Development of a method for the determination of 9 currently used cotton pesticides by gas chromatography with electron capture detection. Talanta 75:1055–60. doi:10.1016/j.talanta.2008.01.032.