Paraquat and Parkinson’s disease: a systematic review and meta-analysis of observational studies

References

• Adler, C. H., and T. G. Beach. 2016. Neuropathological basis of nonmotor manifestations of Parkinson’s disease. Mov. Disord. 31:1114–19. doi:10.1002/mds.16605.
   PubMed Web of Science ®Google Scholar
• Ali, K., and H. R. Morris. 2015. Parkinson’s disease: Chameleons and mimics. Pract. Neurol. 15:14–25. doi:10.1136/practneurol-2014-000849.
   PubMedGoogle Scholar
• Allen, M. T., and L. S. Levy. 2013. Parkinson’s disease and pesticide exposure – A new assessment. Crit. Rev. Toxicol. 43:515–34. doi:10.3109/10408444.2013.798719.
   PubMed Web of Science ®Google Scholar
• Angerer, J., U. Ewers, and M. Wilhelm. 2007. Human biomonitoring: state of the art. Int. J. Hyg. Environ. Health 210:201–28. doi:10.1016/j.ijheh.2007.01.024.
   PubMed Web of Science ®Google Scholar
• ANVISA. Agência Nacional de Vigilância Sanitária. 2017. Analisa a reavaliação toxicológica do ingrediente ativo Paraquate [Analyzes the toxicological revaluation of the active ingredient Paraquat]. http://portal.anvisa.gov.br/documents/219201/2782895/Voto+Renato+Paraquate/fa409d90-a520-4302-9815-f39b683da509.
   Google Scholar
• Bain, P., M. Brin, G. Deuschl, R. Elble, J. Jankovic, L. Findley, W. C. Koller, and R. Pahwa. 2000. Criteria for the diagnosis of essential tremor. Neurology 54:S7.
   PubMed Web of Science ®Google Scholar
• Balshem, H., M. Helfand, H. J. Schünemann, A. D. Oxman, R. Kunz, J. Brozek, G. E. Vist, Y. Falck-Ytter, J. Meerpohl, S. Norris, et al. 2011. GRADE guidelines: 3. Rating the quality of evidence. J. Clin. Epidemiol. 64:401–06. doi:10.1016/j.jclinepi.2010.07.015.
   PubMed Web of Science ®Google Scholar
• Barlow, B. K., M. J. Thiruchelvam, L. Bennice, D. A. Cory-Slechta, N. Ballatori, and E. K. Richfield. 2003. Increased synaptosomal dopamine content and brain concentration of paraquat produced by selective dithiocarbamates. J. Neurochem. 85:1075–86. doi:10.1046/j.1471-4159.2003.01773.x.
   PubMed Web of Science ®Google Scholar
• Bernheimer, H., W. Birkmayer, O. Hornykiewicz, K. Jellinger, and F. Seitelberger. 1973. Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations. J. Neurol. Sci. 20:415–55. doi:10.1016/0022-510x(73)90175-5.
   PubMed Web of Science ®Google Scholar
• Blesa, J., S. Phani, V. Jackson-Lewis, and S. Przedborski. 2012. Classic and new animal models of Parkinson's disease. J Biomed Biotechnol 2012:845618. doi:10.1155/2012/845618.
   PubMedGoogle Scholar
• Blesa, J., I. Trigo-Damas, M. Dileone, N. L. Del Rey, L. F. Hernandez, and J. A. Obeso. 2017. Compensatory mechanisms in Parkinson’s disease: Circuits adaptations and role in disease modification. Exp. Neurol. 298:148–61. doi:10.1016/j.expneurol.2017.10.002.
   PubMed Web of Science ®Google Scholar
• Breckenridge, C. B., C. Berry, E. T. Chang, R. L. Sielken, and J. S. Mandel. 2016. Association between Parkinson’s disease and cigarette smoking, rural living, well-water consumption, farming and pesticide use: Systematic review and meta-analysis. PLoS ONE 11:e0151841. doi:10.1371/journal.pone.0151841.
   PubMed Web of Science ®Google Scholar
• Brent, J., and T. H. Schaeffer. 2011. Systematic review of Parkinsonian syndromes in short- and long-term survivors of paraquat poisoning. J. Occup. Environ. Med. 53:1332–36. doi:10.1097/JOM.0b013e318233775d.
   PubMed Web of Science ®Google Scholar
• Brouwer, M., A. Huss, M. van der Mark, P. C. G. Nijssen, W. M. Mulleners, A. M. G. Sas, T. van Laar, G. R. de Snoo, H. Kromhout, and R. C. H. Vermeulen. 2017. Environmental exposure to pesticides and the risk of Parkinson’s disease in the Netherlands. Environ. Int. 107:100–10. doi:10.1016/j.envint.2017.07.001.
   PubMed Web of Science ®Google Scholar
• Brown, T. P., P. C. Rumsby, A. C. Capleton, L. Rushton, and L. S. Levy. 2006. Pesticides and Parkinson’s disease - Is there a link? Environ. Health Perspect. 114:156–64. doi:10.1289/ehp.8095.
   PubMed Web of Science ®Google Scholar
• Cannon, J. R., and J. T. Greenamyre. 2013. Gene-environment interactions in Parkinson’s disease: Specific evidence in humans and mammalian models. Neurobiol. Dis. 57:38–46. doi:10.1016/j.nbd.2012.06.025.
   PubMed Web of Science ®Google Scholar
• Castello, P. R., D. A. Drechsel, and M. Patel. 2007. Mitochondria are a major source of paraquat-induced reactive oxygen species production in the brain. J. Biol. Chem. 282:14186–93. doi:10.1074/jbc.M700827200.
   PubMed Web of Science ®Google Scholar
• Chaudhuri, K. R., and P. Martinez-Martin. 2008. Quantitation of non-motor symptoms in Parkinson’s disease. Eur. J. Neurol. 15 (Suppl 2):2–7. doi:10.1111/j.1468-1331.2008.02212.x.
   PubMedGoogle Scholar
• Cheng, H. C., C. M. Ulane, and R. E. Burke. 2010. Clinical progression in Parkinson disease and the neurobiology of axons. Ann. Neurol. 67:715–25. doi:10.1002/ana.21995.
   PubMed Web of Science ®Google Scholar
• Cheng, Y. H., W. C. Chou, Y. F. Yang, C. W. Huang, C. M. How, S. C. Chen, W. Y. Chen, N. H. Hsieh, Y. J. Lin, S. H. You, et al. 2018. PBPK/PD assessment for Parkinson’s disease risk posed by airborne pesticide paraquat exposure. Environ. Sci. Pollut. Res. Int. 25:5359–68. doi:10.1007/s11356-017-0875-4.
   PubMed Web of Science ®Google Scholar
• Chinta, S. J., G. Woods, M. Demaria, A. Rane, Y. Zou, A. McQuade, S. Rajagopalan, C. Limbad, D. T. Madden, J. Campisi, et al. 2018. Cellular senescence is induced by the environmental neurotoxin paraquat and contributes to neuropathology linked to Parkinson’s disease. Cell Rep. 22:930–40. doi:10.1016/j.celrep.2017.12.092.
   PubMed Web of Science ®Google Scholar
• Cicchetti, F., J. Drouin-Ouellet, and R. E. Gross. 2009. Environmental toxins and Parkinson’s disease: what have we learned from pesticide-induced animal models?. Trends Pharmacol. Sci. 30:475–83. doi:10.1016/j.tips.2009.06.005.
   PubMed Web of Science ®Google Scholar
• Costello, S., M. Cockburn, J. Bronstein, X. Zhang, and B. Ritz. 2009. Parkinson’s disease and residential exposure to maneb and paraquat from agricultural applications in the Central Valley of California. Am. J. Epidemiol. 169:919–26. doi:10.1093/aje/kwp006.
   PubMed Web of Science ®Google Scholar
• Dauer, W., and S. Przedborski. 2003. Parkinson’s disease: Mechanisms and models. Neuron 39:889–909. doi:10.1016/s0896-6273(03)00568-3.
   PubMed Web of Science ®Google Scholar
• de Rijk, M. C., L. J. Launer, K. Berger, M. M. Breteler, J. F. Dartigues, M. Baldereschi, L. Fratiglioni, A. Lobo, J. Martinez-Lage, C. Trenkwalder, et al. 2000. Prevalence of Parkinson’s disease in Europe: A collaborative study of population-based cohorts. Neurologic diseases in the Elderly research group. Neurology 54:S21–S23.
   PubMed Web of Science ®Google Scholar
• Dhillon, A. S., G. L. Tarbutton, J. L. Levin, G. M. Plotkin, L. K. Lowry, J. T. Nalbone, and S. Shepherd. 2008. Pesticide/environmental exposures and Parkinson’s disease in East Texas. J. Agromed. 13:37–48. doi:10.1080/10599240801986215.
   PubMedGoogle Scholar
• Dick, F. D., G. De Palma, A. Ahmadi, N. W. Scott, G. J. Prescott, J. Bennett, S. Semple, S. Dick, C. Counsell, P. Mozzoni, et al. 2007. Environmental risk factors for Parkinson’s disease and parkinsonism: The Geoparkinson study. Occup. Environ. Med. 64:666–72. doi:10.1136/oem.2006.027003.
   PubMed Web of Science ®Google Scholar
• Dinis-Oliveira, R. J., F. Remião, H. Carmo, J. A. Duarte, A. S. Navarro, M. L. Bastos, and F. Carvalho. 2006. Paraquat exposure as an etiological factor of Parkinson’s disease. Neurotoxicol. 27:1110–22. doi:10.1016/j.neuro.2006.05.012.
   PubMed Web of Science ®Google Scholar
• Dorsey, E. R., R. Constantinescu, J. P. Thompson, K. M. Biglan, R. G. Holloway, K. Kieburtz, F. J. Marshall, B. M. Ravina, G. Schifitto, A. Siderowf, et al. 2007. Projected number of people with Parkinson disease in the most populous nations, 2005 through 2030. Neurology 68:384–86. doi:10.1212/01.wnl.0000247740.47667.03.
   PubMed Web of Science ®Google Scholar
• Durrheim, D. N., and A. Reingold. 2010. Modifying the GRADE framework could benefit public health. J. Epidemiol. Community Health 64:387. doi:10.1136/jech.2009.103226.
   PubMed Web of Science ®Google Scholar
• Elbaz, A., J. Clavel, P. J. Rathouz, F. Moisan, J. P. Galanaud, B. Delemotte, A. Alpérovitch, and C. Tzourio. 2009. Professional exposure to pesticides and Parkinson disease. Ann. Neurol. 66:494–504. doi:10.1002/ana.21717.
   PubMed Web of Science ®Google Scholar
• Elble, R. J. 2000. Diagnostic criteria for essential tremor and differential diagnosis. Neurology 54:S2–S6.
   PubMed Web of Science ®Google Scholar
• Engel, L., H. Checkoway, M. Keifer, N. Seixas, W. Longstreth, K. Scott, K. Hudnellh, W. K. Angerf, and R. Camicioli. 2001. Parkinsonism and occupational exposure to pesticides. Occup. Environ. Med. 58:582–89. doi:10.1136/oem.58.9.582.
   PubMed Web of Science ®Google Scholar
• Fearnley, J. M., and A. J. Lees. 1991. Ageing and Parkinson’s disease: Substantia nigra regional selectivity. Brain 114:2283–301. doi:10.1093/brain/114.5.2283.
   PubMed Web of Science ®Google Scholar
• Fedak, K. M., A. Bernal, Z. A. Capshaw, and S. Gross. 2015. Applying the Bradford Hill criteria in the 21st century: How data integration has changed causal inference in molecular epidemiology. Emerg Themes Epidemiol 12:14. doi:10.1186/s12982-015-0037-4.
   PubMed Web of Science ®Google Scholar
• Fei, Q., and D. W. Ethell. 2008. Maneb potentiates paraquat neurotoxicity by inducing key Bcl-2 family members. J. Neurochem. 105:2091–97. doi:10.1111/j.1471-4159.2008.05293.x.
   PubMed Web of Science ®Google Scholar
• Feng, L. R., and K. A. Maguire-Zeiss. 2011. Dopamine and paraquat enhance alpha-synuclein-induced alterations in membrane conductance. Neurotox Res 20:387–401. doi:10.1007/s12640-011-9255-x.
   PubMed Web of Science ®Google Scholar
• Firestone, J. A., J. I. Lundin, K. M. Powers, T. Smith-Weller, G. M. Franklin, P. D. Swanson, W. T. Longstreth, and H. C. Jr. 2010. Occupational factors and risk of Parkinson’s disease: A population-based case–control study. Am. J. Ind. Med. 53:217–23. doi:10.1002/ajim.20788.
   PubMed Web of Science ®Google Scholar
• Firestone, J. A., T. Smith-Weller, G. Franklin, P. Swanson, W. T. Longstreth, and H. Checkoway. 2005. Pesticides and risk of Parkinson disease. A population-based case-control study. Arch. Neurol. 62:91–95. doi:10.1001/archneur.62.1.91.
   PubMed Web of Science ®Google Scholar
• Fleming, S. M. 2017. Mechanisms of gene-environment interactions in Parkinson’s disease. Curr. Environ. Health Rep. 4:192–99. doi:10.1007/s40572-017-0143-2.
   PubMedGoogle Scholar
• Freire, C., and S. Koifman. 2012. Pesticide exposure and Parkinson’s disease: Epidemiological evidence of association. Neurotoxicol. 33:947–71. doi:10.1016/j.neuro.2012.05.011.
   PubMed Web of Science ®Google Scholar
• Furlong, M., C. M. Tanner, S. M. Goldman, G. S. Bhudhikanok, A. Blair, A. Chade, K. Comyns, J. A. Hoppin, M. Kasten, and M. Korell. 2015. Protective glove use and hygiene habits modify the associations of specific pesticides with Parkinson’s disease. Environ. Int. 75:144–50. doi:10.1016/j.envint.2014.11.002.
   PubMed Web of Science ®Google Scholar
• Gatto, N. M., M. Cockburn, J. Bronstein, A. D. Manthripragada, and B. Ritz. 2009. Well-water consumption and Parkinson’s disease in rural California. Environ. Health Perspect. 117:1912–18. doi:10.1289/ehp.0900852.
   PubMed Web of Science ®Google Scholar
• Gatto, N. M., S. L. Rhodes, A. D. Manthripragada, J. Bronstein, M. Cockburn, M. Farrer, and B. Ritz. 2010. Synuclein gene may interact with environmental factors in increasing risk of Parkinson’s disease. Neuroepidemiology 35:191–95. doi:10.1159/000315157.
   PubMed Web of Science ®Google Scholar
• Gelb, D. J., E. Oliver, and S. Gilman. 1999. Diagnostic criteria for Parkinson disease. Arch. Neurol. 56:33–39. doi:10.1001/archneur.56.1.33.
   PubMed Web of Science ®Google Scholar
• Giasson, B. I., J. E. Duda, I. V. Murray, Q. Chen, J. M. Souza, H. I. Hurtig, H. Ischiropoulos, J. Q. Trojanowski, and V. M. Lee. 2000. Oxidative damage linked to neurodegeneration by selective alpha-synuclein nitration in synucleinopathy lesions. Sci. 290:985–89. doi:10.1126/science.290.5493.985.
   PubMed Web of Science ®Google Scholar
• Goetz, C. G. 2011. The history of Parkinson’s disease: Early clinical descriptions and neurological therapies. Cold Spring Harb. Perspect. Med. 1:a008862. doi:10.1101/cshperspect.a008862.
   PubMed Web of Science ®Google Scholar
• Goldman, S. M., F. Kamel, G. W. Ross, G. S. Bhudhikanok, J. A. Hoppin, M. Korell, C. Marras, C. Meng, D. M. Umbach, and M. Kasten. 2012. Genetic modification of the association of paraquat and Parkinson’s disease. Mov. Disord. 27:1652–58. doi:10.1002/mds.25216.
   PubMed Web of Science ®Google Scholar
• Guyatt, G. H., A. D. Oxman, G. Vist, R. Kunz, J. Brozek, P. Alonso-Coello, V. Montori, E. A. Akl, B. Djulbegovic, Y. Falck-Ytter, et al. 2011a. GRADE guidelines: 4. Rating the quality of evidence - study limitations (risk of bias). J. Clin. Epidemiol. 64:407–15. doi:10.1016/j.jclinepi.2010.07.017.
   PubMed Web of Science ®Google Scholar
• Guyatt, G. H., A. D. Oxman, G. E. Vist, R. Kunz, Y. Falck-Ytter, P. Alonso-Coello, H. J. Schünemann, and GRADE Working Group. 2008. GRADE: An emerging consensus on rating quality of evidence and strength of recommendations. Br. Med. J. 336:924–26. doi:10.1136/bmj.39489.470347.AD.
   PubMed Web of Science ®Google Scholar
• Guyatt, G. H., A. D. Oxman, R. Kunz, J. Brozek, P. Alonso-Coello, D. Rind, P. J. Devereaux, V. M. Montori, B. Freyschuss, G. Vist, et al. 2011b. GRADE guidelines 6. Rating the quality of evidence—imprecision. J. Clin. Epidemiol. 64:1283–93. doi:10.1016/j.jclinepi.2011.01.012.
   PubMed Web of Science ®Google Scholar
• Guyatt, G. H., A. D. Oxman, R. Kunz, J. Woodcock, J. Brozek, M. Helfand, P. Alonso-Coello, P. Glasziou, R. Jaeschke, E. A. Akl, et al. 2011c. GRADE guidelines: 7. Rating the quality of evidence - inconsistency. J. Clin. Epidemiol. 64:1294–302. doi:10.1016/j.jclinepi.2011.03.017.
   PubMed Web of Science ®Google Scholar
• Guyatt, G. H., A. D. Oxman, R. Kunz, J. Woodcock, J. Brozek, M. Helfand, P. Alonso-Coello, Y. Falck-Ytter, R. Jaeschke, G. Vist, et al. 2011d. GRADE guidelines: 8. Rating the quality of evidence - indirectness. J. Clin. Epidemiol. 64:1303–10. doi:10.1016/j.jclinepi.2011.04.014.
   PubMed Web of Science ®Google Scholar
• Guyatt, G. H., A. D. Oxman, S. Sultan, P. Glasziou, E. A. Akl, P. Alonso-Coello, D. Atkins, R. Kunz, J. Brozek, V. Montori, et al. 2011f. GRADE guidelines: 9. Rating up the quality of evidence. J. Clin. Epidemiol. 64:1311–16. doi:10.1016/j.jclinepi.2011.06.004.
   PubMed Web of Science ®Google Scholar
• Guyatt, G. H., A. D. Oxman, V. Montori, G. Vist, R. Kunz, J. Brozek, P. Alonso-Coello, B. Djulbegovic, D. Atkins, Y. Falck-Ytter, et al. 2011e. GRADE guidelines: 5. Rating the quality of evidence - publication bias. J. Clin. Epidemiol. 64:1277–82. doi:10.1016/j.jclinepi.2011.01.011.
   PubMed Web of Science ®Google Scholar
• Guyatt, G. H., and J. W. Busse. 2019. Methods instrument: Tool to assess risk of bias in cohort studies and tool to assess risk of bias in case control studies. In: Evidence partners [Internet]. Accessed June 20, 2017. https://www.evidencepartners.com/resources/methodological-resources.
   Google Scholar
• Hancock, D. B., E. R. Martin, G. M. Mayhew, J. M. Stajich, R. Jewett, M. A. Stacy, B. L. Scott, J. M. Vance, and W. K. Scott. 2008. Pesticide exposure and risk of Parkinson’s disease: A family-based case-control study. BMC Neurol. 8:6. doi:10.1186/1471-2377-8-6.
   PubMed Web of Science ®Google Scholar
• Hernandez, D. G., C. Paisan-Ruiz, A. McInerney-Leo, S. Jain, A. Meyer-Lindenberg, E. W. Evans, K. F. Berman, J. Johnson, G. Auburger, A. A. Schaffer, et al. 2005. Clinical and positron emission tomography of Parkinson’s disease caused by LRRK2. Ann. Neurol. 57:453–56. doi:10.1002/ana.20401.
   PubMed Web of Science ®Google Scholar
• Hertzman, C., M. Wiens, B. Snow, S. Kelly, and D. Calne. 1994. A case-control study of Parkinson’s disease in a horticultural region of British Columbia. Mov. Disord. 9:69–75. doi:10.1002/mds.870090111.
   PubMed Web of Science ®Google Scholar
• Hertzman, C., M. Wiens, and D. Bowering. 1990. Parkinson’s disease: A case-control study of occupational and environmental risk factors. Am. J. Indust. Med. 17:349–55. doi:10.1002/ajim.4700170307.
   PubMed Web of Science ®Google Scholar
• Higgins, J. P. T., D. G. Altman, and J. A. C. Sterne. 2011. Assessing risk of bias in included studies. In Cochrane handbook for systematic reviews of interventions Version 5.1.0, ed. J. P. T. Higgins, and S. Green, Chinchester: The Cochrane Collaboration. http://handbook.cochrane.org/.
   Google Scholar
• Higgins, J. P. T., S. G. Thompson, J. J. Deeks, and D. G. Altman. 2003. Measuring inconsistency in meta-analyses. Br. Med. J. 327:557–60. doi:10.1136/bmj.327.7414.557.
   PubMed Web of Science ®Google Scholar
• Hill, A. B. 1965. The environment and disease: Association or causation? Proc. Roy Soc. Med. 58:295. doi:10.1177/003591576505800503.
   PubMed Web of Science ®Google Scholar
• Huang, D., J. Xu, J. Wang, J. Tong, X. Bai, H. Li, Z. Wang, Y. Huang, Y. Wu, M. Yu, et al. 2017. Dynamic changes in the nigrostriatal pathway in the MPTP mouse model of Parkinson’s disease. Parkinson’s Dis. 2017:9349487. doi:10.1155/2017/9349487.
   PubMedGoogle Scholar
• Hughes, A. J., S. E. Daniel, L. Kilford, and A. J. Lees. 1992b. Accuracy of clinical diagnosis of idiopathic Parkinson’s disease. A clinico-pathological study of 100 cases. J. Neurol. Neurosurg. Psychiat. 55:181–84. doi:10.1136/jnnp.55.3.181.
   PubMed Web of Science ®Google Scholar
• Kalia, L. V., and A. E. Lang. 2015. Parkinson’s disease. Lancet 386:896–912. doi:10.1016/S0140-6736(14)61393-3.
   PubMed Web of Science ®Google Scholar
• Kamel, F., C. Tanner, D. Umbach, J. A. Hoppin, M. C. R. Alavanja, A. Blair, K. Comyns, S. Goldman, M. Korell, J. Langston, et al. 2007. Pesticide exposure and self-reported Parkinson’s disease in the agricultural health study. Am. J. Epidemiol. 165:364–74. doi:10.1093/aje/kwk024.
   PubMed Web of Science ®Google Scholar
• Kamel, F., S. M. Goldman, D. M. Umbach, H. Chen, G. Richardson, M. R. Barber, C. Meng, C. Marras, M. Korell, M. Kasten, et al. 2014. Dietary fat intake, pesticide use, and Parkinson’s disease. Parkinsonism Relat. Disord. 20:82–87. doi:10.1016/j.parkreldis.2013.09.023.
   PubMed Web of Science ®Google Scholar
• Kosaka, K. 2014. Lewy body disease and dementia with Lewy bodies. Proc. Jpn. Acad., Ser. B, Phys. Biol. Sci. 90:301–06. doi:10.2183/pjab.90.301.
   PubMed Web of Science ®Google Scholar
• Kuopio, A. M., R. J. Marttila, H. Helenius, and U. K. Rinne. 1999. Environmental risk factors in Parkinson’s disease. Mov. Disord. 14:928–39.
   PubMed Web of Science ®Google Scholar
• Kuter, K., P. Nowak, K. Golembiowska, and K. Ossowska. 2010. Increased reactive oxygen species production in the brain after repeated low-dose pesticide paraquat exposure in rats: A comparison with peripheral tissues. Neurochem. Res. 35:1121–30. doi:10.1007/s11064-010-0163-x.
   PubMed Web of Science ®Google Scholar
• Lang, A. E., and A. M. Lozano, Parkinson’s disease. 1998. First of two parts. N. Engl. J. Med. 339: 1044–53. doi: 10.1056/NEJM199810083391506.
   PubMed Web of Science ®Google Scholar
• Langston, J. W. 2017. The MPTP story. J. Parkinsons Dis. 7:S11–S19. doi:10.3233/JPD-179006.
   PubMedGoogle Scholar
• Lee, P. C., Y. Bordelon, J. Bronstein, and B. Ritz. 2012. Traumatic brain injury, paraquat exposure, and their relationship to Parkinson disease. Neurology 79:2061–66. doi:10.1212/WNL.0b013e3182749f28.
   PubMed Web of Science ®Google Scholar
• Li, A. A., P. J. Mink, L. J. McIntosh, M. J. Teta, and B. Finley. 2005. Evaluation of epidemiologic and animal data associating pesticides with Parkinson’s disease. J. Occup. Environ. Med. 47:1059–87.
   PubMed Web of Science ®Google Scholar
• Liou, H. H., M. C. Tsai, C. J. Chen, J. S. Jeng, Y. C. Chang, S. Y. Chen, and R. C. Chen. 1997. Environmental risk factors and Parkinson’s disease: A case-control study in Taiwan. Neurology 48:1583–88. doi:10.1212/wnl.48.6.1583.
   PubMed Web of Science ®Google Scholar
• Manning-Bog, A. B., A. L. McCormack, J. Li, V. N. Uversky, A. L. Fink, and D. A. Di Monte. 2002. The herbicide paraquat causes up-regulation and aggregation of alpha-synuclein in mice: Paraquat and alpha-synuclein. J. Biol. Chem. 277:1641–44. doi:10.1074/jbc.C100560200.
   PubMed Web of Science ®Google Scholar
• McCormack, A. L., M. Thiruchelvam, A. B. Manning-Bog, C. Thiffault, J. W. Langston, D. A. Cory-Slechta, and D. A. Di Monte. 2002. Environmental risk factors and Parkinson’s disease: Selective degeneration of nigral dopaminergic neurons caused by the herbicide paraquat. Neurobiol. Dis. 10:119–27.
   PubMed Web of Science ®Google Scholar
• Meredith, G. E., and D. J. Rademacher. 2011. MPTP mouse models of Parkinson’s disease: An update. J. Parkinsons Dis. 1:19–33. doi:10.3233/JPD-2011-11023.
   PubMedGoogle Scholar
• Miller, G. W. 2007. Paraquat: The red herring of Parkinson’s disease research. Toxicol. Sci. 100:1–2. doi:10.1093/toxsci/kfm223.
   PubMed Web of Science ®Google Scholar
• Moretto, A., and C. Colosio. 2013. The role of pesticide exposure in the genesis of Parkinson’s disease: Epidemiological studies and experimental data. Toxicol. 307:24–34. doi:10.1016/j.tox.2012.11.021.
   PubMed Web of Science ®Google Scholar
• Narayan, S., Z. Liew, J. M. Bronstein, and B. Ritz. 2017. Occupational pesticide use and Parkinson’s disease in the Parkinson environment gene (PEG) study. Environ. Int. 107:266–73. doi:10.1016/j.envint.2017.04.010.
   PubMed Web of Science ®Google Scholar
• NTP. National Toxicology Program. 2018. Protocol for scoping review of paraquat dichloride exposure and Parkinson’s disease. https://ntp.niehs.nih.gov/ntp/ohat/parkinson/parkinsons_protocol_508.pdf.
   Google Scholar
• Ntzani, E. E., M. Chondrogiorgi, G. Nitritsos, and I. Tzoulaki. 2013. Literature review on epidemiological studies linking exposure to pesticides and health effects. EFSA Supp Publ 10:497EN. http://onlinelibrary.wiley.com/doi/10.2903/sp.efsa.2013.EN-497/abstract.
   Google Scholar
• Ossowska, K., J. Wardas, M. Smialowska, K. Kuter, T. Lenda, J. M. Wieronska, B. Zieba, P. Nowak, J. Dabrowska, A. Bortel, et al. 2005. A slowly developing dysfunction of dopaminergic nigrostriatal neurons induced by long-term paraquat administration in rats: An animal model of preclinical stages of Parkinson’s disease? Eur. J. Neurosci. 22:1294–304. doi:10.1111/j.1460-9568.2005.04301.x.
   PubMed Web of Science ®Google Scholar
• Pesch, B., B. Kendzia, P. Gustavsson, K. H. Jöckel, G. Johnen, H. Pohlabeln, A. Olsson, W. Ahrens, I. M. Gross, I. Brüske, et al. 2012. Cigarette smoking and lung cancer – relative risk estimates for the major histological types from a pooled analysis of case-control studies. Int. J. Cancer 131:1210–19. doi:10.1002/ijc.27339.
   PubMed Web of Science ®Google Scholar
• Pezzoli, G., and E. Cereda. 2013. Exposure to pesticides or solvents and risk of Parkinson disease. Neurology 80:2035–41. doi:10.1212/WNL.0b013e318294b3c8.
   PubMed Web of Science ®Google Scholar
• Plato, N., and G. Steineck. 1993. Methodology and utility of a job-exposure matrix. Am. J. Ind. Med. 23:491–502.
   PubMed Web of Science ®Google Scholar
• Pouchieu, C., C. Piel, C. Carles, A. Gruber, C. Helmer, S. Tual, E. Marcotullio, P. Lebailly, and I. Baldi. 2018. Pesticide use in agriculture and Parkinson’s disease in the AGRICAN cohort study. Int. J. Epidemiol. 47:299–310. doi:10.1093/ije/dyx225.
   PubMed Web of Science ®Google Scholar
• Ribeiro, A. I., A. Olhero, H. Teixeira, A. Magalhães, and M. F. Pina. 2014. Tools for address georeferencing – limitations and opportunities every public health professional should be aware of. PLoS ONE 9:e114130. doi:10.1371/journal.pone.0114130.
   PubMed Web of Science ®Google Scholar
• Richardson, J. R. 2005. Paraquat neurotoxicity is distinct from that of MPTP and rotenone. Toxicol. Sci. 88:193–201. doi:10.1093/toxsci/kfi304.
   PubMed Web of Science ®Google Scholar
• Ritz, B. R., A. D. Manthripragada, S. Costello, S. J. Lincoln, M. J. Farrer, M. Cockburn, and J. Bronstein. 2009. Dopamine transporter genetic variants and pesticides in Parkinson’s disease. Environ. Health Perspect. 117:964–69. doi:10.1289/ehp.0800277.
   PubMed Web of Science ®Google Scholar
• Rugbjerg, K., M. A. Harris, H. Shen, S. A. Marion, J. K. Tsui, and K. Teschke. 2011. Pesticide exposure and risk of Parkinson’s disease – A population-based case–control study evaluating the potential for recall bias. Scand. J. Work Environ. Health 27:427–36. doi:10.5271/sjweh.3142.
   Google Scholar
• Sanders, L. H., K. C. Paul, E. H. Howlett, H. Lawal, S. Boppana, J. M. Bronstein, B. Ritz, and J. T. Greenamyre. 2017. Editor’s highlight: Base excision repair variants and pesticide exposure increase Parkinson’s disease risk. Toxicol. Sci. 158:188–98. doi:10.1093/toxsci/kfx086.
   PubMed Web of Science ®Google Scholar
• Schünemann, H., S. Hill, G. Guyatt, E. A. Akl, and F. Ahmed. 2011. The GRADE approach and Bradford Hill’s criteria for causation. J. Epidemiol. Community Health 65:392–95. doi:10.1136/jech.2010.119933.
   PubMed Web of Science ®Google Scholar
• Seidler, A., W. Hellenbrand, B. P. Robra, P. Vieregge, P. Nischan, and J. Joerg. 1996. Possible environmental, occupational, and other etiologic factors for Parkinson’s disease: A case-control study in Germany. Neurology 46:1275–84. doi:10.1212/wnl.46.5.1275.
   PubMed Web of Science ®Google Scholar
• Semchuk, K. M., E. J. Love, and R. G. Lee. 1992. Parkinson’s disease and exposure to agricultural work and pesticide chemicals. Neurology 42:1328–35. doi:10.1212/wnl.42.7.1328.
   PubMed Web of Science ®Google Scholar
• Shichiri, M. 2014. The role of lipid peroxidation in neurological disorders. J. Clin. Biochem. Nutr. 54:151–60. doi:10.3164/jcbn.14-10.
   PubMed Web of Science ®Google Scholar
• Shimizu, K., K. Ohtaki, K. Matsubara, K. Aoyama, T. Uezono, O. Saito, M. Suno, K. Ogawa, N. Hayase, K. Kimura, et al. 2001. Carrier-mediated processes in blood–brain barrier penetration and neural uptake of paraquat. Brain Res. 906:135–42. doi:10.1016/s0006-8993(01)02577-x.
   PubMed Web of Science ®Google Scholar
• Singleton, A. B., M. Farrer, J. Johnson, A. Singleton, S. Hague, J. Kachergus, M. Hulihan, T. Peuralinna, A. Dutra, R. Nussbaum, et al. 2003. Alpha-synuclein locus triplication causes Parkinson’s disease. Sci. 302:841. doi:10.1126/science.1090278.
   PubMed Web of Science ®Google Scholar
• Smith, D. M. 2018. Could a common mechanism of protein degradation impairment underlie many neurodegenerative diseases? J. Exp. Neurosci. 12:1179069518794675. doi:10.1177/1179069518794675.
   Web of Science ®Google Scholar
• Stroup, D. F., J. A. Berlin, S. C. Morton, I. Olkin, G. D. Williamson, D. Rennie, D. Moher, B. J. Becker, T. A. Sipe, and S. B. Thacker. 2000. Meta-analysis of observational studies in epidemiology: a proposal for reporting. J. Am. Med. Assoc. 283:2008–12. doi:10.1001/jama.283.15.2008.
   PubMed Web of Science ®Google Scholar
• Sulzer, D., R. N. Alcalay, F. Garretti, L. Cote, E. Kanter, J. Agin-Liebes, C. Liong, C. McMurtrey, W. H. Hildebrand, X. Mao, et al. 2017. T cells from patients with Parkinson’s disease recognize α-synuclein peptides. Nature 546:656–61. doi:10.1038/nature22815.
   PubMed Web of Science ®Google Scholar
• Swaen, G., and L. van Amelsvoort. 2009. A weight of evidence approach to causal inference. J. Clin. Epidemiol. 62:270–77. doi:10.1016/j.jclinepi.2008.06.013.
   PubMed Web of Science ®Google Scholar
• Tanner, C. M., F. Kamel, G. W. Ross, J. A. Hoppin, S. M. Goldman, M. Korell, C. Marras, G. S. Bhudhikanok, M. Kasten, A. R. Chade, et al. 2011. Rotenone, paraquat, and Parkinson’s disease. Environ. Health Perspect. 119:866–72. doi:10.1289/ehp.1002839.
   PubMed Web of Science ®Google Scholar
• Tanner, C. M., G. W. Ross, S. A. Jewell, R. A. Hauser, J. Jankovic, S. A. Factor, S. Bressman, A. Deligtisch, C. Marras, K. E. Lyons, et al. 2009. Occupation and risk of parkinsonism. A multicenter case-control study. Arch. Neurol. 66:1106–13. doi:10.1001/archneurol.2009.195.
   PubMed Web of Science ®Google Scholar
• The Nordic Cochrane Centre. 2011. The cochrane collaboration. Review manager (RevMan). 5.3. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration.
   Google Scholar
• Vaccari, C., R. El Dib, and J. L. V. de Camargo. 2017. Paraquat and Parkinson’s disease: A systematic review protocol according to the OHAT approach for hazard identification. Syst. Rev. 6:98. doi:10.1186/s13643-017-0491-x.
   PubMed Web of Science ®Google Scholar
• van der Mark, M., M. Brouwer, H. Kromhout, P. Nijssen, A. Huss, and R. Vermeulen. 2012.Is pesticide use related to Parkinson Disease? Some clues to heterogeneity in study results. Environ Health Perspect 120: 340–47. doi:10.1289/ehp.1103881.
   Google Scholar
• van Der Mark, M., R. Vermeulen, P. C. Nijssen, W. M. Mulleners, A. M. Sas, T. Van Laar, M. Brouwer, A. Huss, and H. Kromhout. 2014. Occupational exposure to pesticides and endotoxin and Parkinson disease in the Netherlands. Occup. Environ. Med. 71:757–64. doi:10.1136/oemed-2014-102170.
   PubMed Web of Science ®Google Scholar
• Van Maele-Fabry, G., P. Hoet, F. Vilain, and D. Lison. 2012. Occupational exposure to pesticides and Parkinson’s disease: A systematic review and meta-analysis of cohort studies. Environ. Int. 46:30–43. doi:10.1016/j.envint.2012.05.004.
   PubMed Web of Science ®Google Scholar
• Wakabayashi, K., K. Tanji, F. Mori, and H. Takahashi. 2007. The Lewy body in Parkinson’s disease: Molecules implicated in the formation and degradation of α-synuclein aggregates. Neuropathology 27:494–506.
   PubMed Web of Science ®Google Scholar
• Wang, A., S. Costello, M. Cockburn, X. Zhang, J. Bronstein, and B. Ritz. 2011. Parkinson’s disease risk from ambient exposure to pesticides. Eur. J. Epidemiol. 26:547–55. doi:10.1007/s10654-011-9574-5.
   PubMed Web of Science ®Google Scholar
• Warner, T. T., and A. H. Schapira. 2003. Genetic and environmental factors in the cause of Parkinson’s disease. Ann. Neurol. 53:16–25. doi:10.1002/ana.10487.
   PubMed Web of Science ®Google Scholar
• Weed, D. L. 2005. Weight of evidence: A review of concept and methods. Risk Anal. 25:1545–57. doi:10.1111/j.1539-6924.2005.00699.x.
   PubMed Web of Science ®Google Scholar
• Wenning, G. K., I. Litvan, and E. Tolosa. 2011. Milestones in atypical and secondary Parkinsonisms. Mov. Disord. 26:1083–95. doi:10.1002/mds.23713.
   PubMed Web of Science ®Google Scholar
• Zhang, X. F., M. Thompson, and Y. H. Xu. 2016. Multifactorial theory applied to the neurotoxicity of paraquat and paraquat-induced mechanisms of developing Parkinson’s disease. Lab. Invest. 96:496–507. doi:10.1038/labinvest.2015.161.
   PubMed Web of Science ®Google Scholar