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Journal of Toxicology and Environmental Health, Part B
Critical Reviews
Volume 23, 2020 - Issue 7
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Review

Effects of ambient particulate matter on vascular tissue: a review

Kristina Shkirkovaa Department of Neurosurgery, Zilkha Neurogenetic Institute, University of Southern California, Los Angeles, USACorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-9288-4258View further author information
ORCID Icon,
Krista Lamorie-Footea Department of Neurosurgery, Zilkha Neurogenetic Institute, University of Southern California, Los Angeles, USA;b Department of Neurosurgery, Keck School of Medicine, University of Southern California, Los Angeles, USAView further author information
,
Michelle Connora Department of Neurosurgery, Zilkha Neurogenetic Institute, University of Southern California, Los Angeles, USA;b Department of Neurosurgery, Keck School of Medicine, University of Southern California, Los Angeles, USAView further author information
,
Arati Patela Department of Neurosurgery, Zilkha Neurogenetic Institute, University of Southern California, Los Angeles, USA;b Department of Neurosurgery, Keck School of Medicine, University of Southern California, Los Angeles, USAORCID Iconhttps://orcid.org/0000-0002-2300-0391View further author information
ORCID Icon,
Giuseppe Barisanoa Department of Neurosurgery, Zilkha Neurogenetic Institute, University of Southern California, Los Angeles, USAView further author information
,
Hans Baertscha Department of Neurosurgery, Zilkha Neurogenetic Institute, University of Southern California, Los Angeles, USA;b Department of Neurosurgery, Keck School of Medicine, University of Southern California, Los Angeles, USAView further author information
,
Qinghai Liua Department of Neurosurgery, Zilkha Neurogenetic Institute, University of Southern California, Los Angeles, USAView further author information
,
Todd E. Morganc Department of Gerontology, Leonard Davis School of Gerontology, University of Southern California, Los Angeles, USAView further author information
,
Constantinos Sioutasd Department of Civil and Environmental Engineering, Viterbi School of Engineering, University of Southern California, Los Angeles, USAView further author information
&
William J. Macka Department of Neurosurgery, Zilkha Neurogenetic Institute, University of Southern California, Los Angeles, USA;b Department of Neurosurgery, Keck School of Medicine, University of Southern California, Los Angeles, USA;e Department of Neurosurgery, University of Southern California, Los Angeles, CA, USAView further author information
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Pages 319-350 | Published online: 24 Sep 2020

References

  • Akintoye, E., L. Shi, I. Obaitan, M. Olusunmade, Y. Wang, J. D. Newman, and J. A. Dodson. 2016. Association between fine particulate matter exposure and subclinical atherosclerosis: A meta-analysis. Eur. J. Prev. Cardiol. 23:602–12. doi:10.1177/2047487315588758.
  • Alexeeff, S. E., B. A. Coull, A. Gryparis, H. Suh, D. Sparrow, P. S. Vokonas, and J. Schwartz. 2011. Medium-term exposure to traffic-related air pollution and markers of inflammation and endothelial function. Environ. Health Perspect. 119 (4):481–86. doi:10.1289/ehp.1002560.
  • Alfaro-Moreno, E., T. S. Nawrot, A. Nemmar, and B. Nemery. 2007. Particulate matter in the environment: Pulmonary and cardiovascular effects. Curr. Opin. Pulm. Med. 13 (2):98–106. doi:10.1097/MCP.0b013e328013f47e.
  • An, Z., Y. Jin, J. Li, W. Li, and W. Wu. 2018. Impact of particulate air pollution on cardiovascular health. Curr. Allergy Asthma Rep. 18 (3):1–15. doi:10.1007/s11882-018-0768-8.
  • Araujo, J. A., B. Barajas, M. Kleinman, X. Wang, B. J. Bennett, K. W. Gong, M. Navab, J. Harkema, C. Sioutas, A. J. Lusis, et al.. 2008. Ambient particulate pollutants in the ultrafine range promote early atherosclerosis and systemic oxidative stress. Circ. Res. 102 (5):589–96. doi:10.1161/CIRCRESAHA.107.164970.
  • Armijos, R. X., M. M. Weigel, O. B. Myers, W. W. Li, M. Racines, and M. Berwick. 2015. Residential exposure to urban traffic is associated with increased carotid intima-media thickness in children. J. Environ. Public Health 215:713540.
  • Bai, N., T. Kido, H. Suzuki, G. Yang, T. J. Kavanagh, J. D. Kaufman, M. E. Rosenfeld, C. van Breemen, and S. F. Eeden. 2011. Changes in atherosclerotic plaques induced by inhalation of diesel exhaust. Atherosclerosis 216:299–306. doi:10.1016/j.atherosclerosis.2011.02.019.
  • Bai, Y., and Q. Sun. 2016. Fine particulate matter air pollution and atherosclerosis: Mechanistic insights. Biochim. Biophys. Acta 1860:2863–68. doi:10.1016/j.bbagen.2016.04.030.
  • Bai, Y., A. K. Suzuki, and M. Sagai. 2001. The cytotoxic effects of diesel exhaust particles on human pulmonary artery endothelial cells in vitro: Role of active oxygen species. Free Radic. Biol. Med. 30:555–62. doi:10.1016/S0891-5849(00)00499-8.
  • Barath, S., N. L. Mills, M. Lundback, H. Tornqvist, A. J. Lucking, J. P. Langrish, S. Soderberg, C. Boman, R. Westerholm, J. Londahl, et al.. 2010. Impaired vascular function after exposure to diesel exhaust generated at urban transient running conditions. Part Fibre Toxicol 7:1–19. doi:10.1186/1743-8977-7-19.
  • Bauer, M., S. Moebus, S. Mohlenkamp, N. Dragano, M. Nonnemacher, M. Fuchsluger, C. Kessler, H. Jakobs, M. Memmesheimer, R. Erbel, et al.. 2010. Urban particulate matter air pollution is associated with subclinical atherosclerosis: Results from the HNR (Heinz Nixdorf Recall) study. J. Am. Coll. Cardiol. 56:1803–08. doi:10.1016/j.jacc.2010.04.065.
  • Bell, G., S. Mora, P. Greenland, M. Tsai, E. Gill, and J. D. Kaufman. 2017. Association of air pollution exposures with high-density lipoprotein cholesterol and particle number: The multi-ethnic study of atherosclerosis. Arterioscler. Thromb. Vasc. Biol. 37:976–82. doi:10.1161/ATVBAHA.116.308193.
  • Boovarahan, S. R., and G. A. Kurian. 2018. Mitochondrial dysfunction: A key player in the pathogenesis of cardiovascular diseases linked to air pollution. Rev. Environ. Health 33:111–22. doi:10.1515/reveh-2017-0025.
  • Bourdrel, T., M. A. Bind, Y. Bejot, O. Morel, and J. F. Argacha. 2017. Cardiovascular effects of air pollution. Arch. Cardiovasc. Dis. 110:634–42. doi:10.1016/j.acvd.2017.05.003.
  • Brauner, E. V., P. Moller, L. Barregard, L. O. Dragsted, M. Glasius, P. Wahlin, P. Vinzents, O. Raaschou-Nielsen, and S. Loft. 2008. Exposure to ambient concentrations of particulate air pollution does not influence vascular function or inflammatory pathways in young healthy individuals. Part Fibre Toxicol 5:13–19. doi:10.1186/1743-8977-5-13.
  • Briet, M., C. Collin, S. Laurent, A. Tan, M. Azizi, M. Agharazii, X. Jeunemaitre, F. Alhenc-Gelas, and P. Boutouyrie. 2007. Endothelial function and chronic exposure to air pollution in normal male subjects. Hypertension 50:970–76. doi:10.1161/HYPERTENSIONAHA.107.095844.
  • Brook, R. D. 2008. Cardiovascular effects of air pollution. Clin. Sci. 115:175–87. doi:10.1042/CS20070444.
  • Brook, R. D., J. R. Brook, B. Urch, R. Vincent, S. Rajagopalan, and F. Silverman. 2002. Inhalation of fine particulate air pollution and ozone causes acute arterial vasoconstriction in healthy adults. Circulation 105:1534–36. doi:10.1161/01.CIR.0000013838.94747.64.
  • Brook, R. D., B. Franklin, W. Cascio, Y. Hong, G. Howard, M. Lipsett, R. Luepker, M. Mittleman, J. Samet, S. C. Smith Jr., et al.. 2004. Air pollution and cardiovascular disease: A statement for healthcare professionals from the Expert Panel on Population and Prevention Science of the American Heart Association. Circulation 109:2655–71. doi:10.1161/01.CIR.0000128587.30041.C8.
  • Brook, R. D., and S. Rajagopalan. 2010. Particulate matter air pollution and atherosclerosis. Curr. Atheroscler Rep. 12:291–300. doi:10.1007/s11883-010-0122-7.
  • Brook, R. D., S. Rajagopalan, C. A. Pope 3rd, J. R. Brook, A. Bhatnagar, A. V. Diez-Roux, F. Holguin, Y. Hong, R. V. Luepker, M. A. Mittleman, et al.. 2010. Particulate matter air pollution and cardiovascular disease: An update to the scientific statement from the American Heart Association. Circulation 121:2331–78. doi:10.1161/CIR.0b013e3181dbece1.
  • Burnett, R., H. Chen, M. Szyszkowicz, N. Fann, B. Hubbell, C. A. Pope 3rd, J. S. Apte, M. Brauer, A. Cohen, S. Weichenthal, et al.. 2018. Global estimates of mortality associated with long-term exposure to outdoor fine particulate matter. Proc. Natl. Acad. Sci. 115:9592–97. doi:10.1073/pnas.1803222115.
  • Campen, M. J., N. S. Babu, G. A. Helms, S. Pett, J. Wernly, R. Mehran, and J. D. McDonald. 2005. Nonparticulate components of diesel exhaust promote constriction in coronary arteries from ApoE-/- mice. Toxicol. Sci. 88:95–102. doi:10.1093/toxsci/kfi283.
  • Campen, M. J., A. K. Lund, T. L. Knuckles, D. J. Conklin, B. Bishop, D. Young, S. Seilkop, J. Seagrave, M. D. Reed, and J. D. McDonald. 2010. Inhaled diesel emissions alter atherosclerotic plaque composition in ApoE(-/-) mice. Toxicol. Appl. Pharmacol. 242:310–17. doi:10.1016/j.taap.2009.10.021.
  • Cao, Y., K. Jantzen, A. C. Gouveia, A. Skovmand, M. Roursgaard, S. Loft, and P. Moller. 2015. Automobile diesel exhaust particles induce lipid droplet formation in macrophages in vitro. Environ. Toxicol. Pharmacol. 40:164–71. doi:10.1016/j.etap.2015.06.012.
  • Cao, Y., J. Long, Y. Ji, G. Chen, Y. Shen, Y. Gong, and J. Li. 2016. Foam cell formation by particulate matter (PM) exposure: A review. Inhal. Toxicol. 28:583–90. doi:10.1080/08958378.2016.1236157.
  • Channell, M. M., M. L. Paffett, R. B. Devlin, M. C. Madden, and M. J. Campen. 2012. Circulating factors induce coronary endothelial cell activation following exposure to inhaled diesel exhaust and nitrogen dioxide in humans: Evidence from a novel translational in vitro model. Toxicol. Sci. 127:179–86. doi:10.1093/toxsci/kfs084.
  • Chen, C. C., P. S. Chen, and C. Y. Yang. 2019. Relationship between fine particulate air pollution exposure and human adult life expectancy in Taiwan. J. Toxicol. Environ. Health Part A 82:826–32. doi:10.1080/15287394.2019.1658386.
  • Chen, T., G. Jia, Y. Wei, and J. Li. 2013. Beijing ambient particle exposure accelerates atherosclerosis in ApoE knockout mice. Toxicol. Lett. 223:146–53. doi:10.1016/j.toxlet.2013.09.004.
  • Cherng, T. W., M. L. Paffett, O. Jackson-Weaver, M. J. Campen, B. R. Walker, and N. L. Kanagy. 2011. Mechanisms of diesel-induced endothelial nitric oxide synthase dysfunction in coronary arterioles. Environ. Health Perspect. 119:98–103. doi:10.1289/ehp.1002286.
  • Chuang, K. J., C. C. Chan, T. C. Su, C. T. Lee, and C. S. Tang. 2007. The effect of urban air pollution on inflammation, oxidative stress, coagulation, and autonomic dysfunction in young adults. Am. J. Respir. Crit. Care Med. 176:370–76. doi:10.1164/rccm.200611-1627OC.
  • Cohen, A. J., M. Brauer, R. Burnett, H. R. Anderson, J. Frostad, K. Estep, K. Balakrishnan, B. Brunekreef, L. Dandona, R. Dandona, et al.. 2017. Estimates and 25-year trends of the global burden of disease attributable to ambient air pollution: An analysis of data from the Global Burden of Diseases Study. Lancet 389:1907–18. doi:10.1016/S0140-6736(17)30505-6.
  • Cook-Mills, J. M., M. E. Marchese, and H. Abdala-Valencia. 2011. Vascular cell adhesion molecule-1 expression and signaling during disease: Regulation by reactive oxygen species and antioxidants. Antioxid. Redox Signal. 15:1607–38. doi:10.1089/ars.2010.3522.
  • Cosselman, K. E., A. Navas-Acien, and J. D. Kaufman. 2015. Environmental factors in cardiovascular disease. Nat. Rev. Cardiol 12:627–42.
  • Dabass, A., E. O. Talbott, A. Venkat, J. Rager, G. M. Marsh, R. K. Sharma, and F. Holguin. 2016. Association of exposure to particulate matter (PM2.5) air pollution and biomarkers of cardiovascular disease risk in adult NHANES participants. Int. J. Hyg. Environ. Health 219:301–10. doi:10.1016/j.ijheh.2015.12.002.
  • Davel, A. P., M. Lemos, L. M. Pastro, S. C. Pedro, P. A. de Andre, C. Hebeda, S. H. Farsky, P. H. Saldiva, and L. V. Rossoni. 2012. Endothelial dysfunction in the pulmonary artery induced by concentrated fine particulate matter exposure is associated with local but not systemic inflammation. Toxicology 295:39–46. doi:10.1016/j.tox.2012.02.004.
  • Donaldson, K., V. Stone, A. Seaton, and W. MacNee. 2001. Ambient particle inhalation and the cardiovascular system: Potential mechanisms. Environ. Health Perspect. 109:523–27.
  • Du, X., S. Jiang, X. Zeng, J. Zhang, K. Pan, J. Zhou, Y. Xie, H. Kan, W. Song, Q. Sun, et al.. 2018. Air pollution is associated with the development of atherosclerosis via the cooperation of CD36 and NLRP3 inflammasome in ApoE(-/-) mice. Toxicol. Lett. 290:123–32. doi:10.1016/j.toxlet.2018.03.022.
  • Du, X. M., M. J. Kim, L. Hou, W. Le Goff, M. J. Chapman, M. Van Eck, L. K. Curtiss, J. R. Burnett, S. P. Cartland, C. M. Quinn, et al.. 2015. HDL particle size is a critical determinant of ABCA1-mediated macrophage cellular cholesterol export. Circ. Res. 116:1133–42. doi:10.1161/CIRCRESAHA.116.305485.
  • Du, Y., X. Xu, M. Chu, Y. Guo, and J. Wang. 2016. Air particulate matter and cardiovascular disease: The epidemiological, biomedical and clinical evidence. J. Thorac Dis 8:8–19.
  • Fang, S. C., A. Cassidy, and D. C. Christiani. 2010. A systematic review of occupational exposure to particulate matter and cardiovascular disease. Int. J. Environ. Res. Public Health 7:1773–806. doi:10.3390/ijerph7041773.
  • Fiordelisi, A., P. Piscitelli, B. Trimarco, E. Coscioni, G. Iaccarino, and D. Sorriento. 2017. The mechanisms of air pollution and particulate matter in cardiovascular diseases. Heart Fail Rev. 22:337–47. doi:10.1007/s10741-017-9606-7.
  • Floyd, H. S., L. C. Chen, B. Vallanat, and K. Dreher. 2009. Fine ambient air particulate matter exposure induces molecular alterations associated with vascular disease progression within plaques of atherosclerotic susceptible mice. Inhal. Toxicol. 21:394–403. doi:10.1080/08958370802317745.
  • Forman, H. J., and C. E. Finch. 2018. A critical review of assays for hazardous components of air pollution. Free Radic. Biol. Med. 117:202–17. doi:10.1016/j.freeradbiomed.2018.01.030.
  • Frampton, M. W. 2006. Inflammation and airborne particles. Clin. Occup. Environ. Med. 5:797–815.
  • Frampton, M. W. 2007. Does inhalation of ultrafine particles cause pulmonary vascular effects in humans. Inhal. Toxicol. 19:75–79. doi:10.1080/08958370701495071.
  • Franchini, M., A. Guida, A. Tufano, and A. Coppola. 2012. Air pollution, vascular disease and thrombosis: Linking clinical data and pathogenic mechanisms. J. Thromb. Haemost. 10:2438–51. doi:10.1111/jth.12006.
  • Franchini, M., and P. M. Mannucci. 2009. Particulate air pollution and cardiovascular risk: Short-term and long-term effects. Semin. Thromb. Hemost. 35:665–70. doi:10.1055/s-0029-1242720.
  • Franchini, M., and P. M. Mannucci. 2011. Thrombogenicity and cardiovascular effects of ambient air pollution. Blood 118:2405–12. doi:10.1182/blood-2011-04-343111.
  • Franklin, B. A., R. Brook, and C. Arden Pope 3rd. 2015. Air pollution and cardiovascular disease. Curr. Problem Cardiol. 40:207–38. doi:10.1016/j.cpcardiol.2015.01.003.
  • Gan, W. Q., R. W. Allen, M. Brauer, H. W. Davies, G. B. Mancini, and S. A. Lear. 2014. Long-term exposure to traffic-related air pollution and progression of carotid artery atherosclerosis: A prospective cohort study. BMJ Open 4:4–743. doi:10.1136/bmjopen-2013-004743.
  • Gill, E. A., C. L. Curl, S. D. Adar, R. W. Allen, A. H. Auchincloss, M. S. O’Neill, S. K. Park, V. C. Van Hee, A. V. Diez Roux, and J. D. Kaufman. 2011. Air pollution and cardiovascular disease in the Multi-Ethnic Study of Atherosclerosis. Prog. Cardiovasc. Dis. 53:353–60. doi:10.1016/j.pcad.2011.02.001.
  • Gonzalez-Flecha, B. 2004. Oxidant mechanisms in response to ambient air particles. Mol. Aspects Med. 25:169–82. doi:10.1016/j.mam.2004.02.017.
  • Grahame, T. J., and R. B. Schlesinger. 2010. Cardiovascular health and particulate vehicular emissions: A critical evaluation of the evidence. Air Qual Atmos Health 3:3–27.
  • Gray, D. L., L. A. Wallace, M. C. Brinkman, S. S. Buehler, and C. La Londe. 2015. Respiratory and cardiovascular effects of metals in ambient particulate matter: A critical review. Rev. Environ. Contam. Toxicol. 234:135–203.
  • Green, R., R. Broadwin, B. Malig, R. Basu, E. B. Gold, L. Qi, B. Sternfeld, J. T. Bromberger, G. A. Greendale, H. M. Kravitz, et al.. 2016. Long- and short-term exposure to air pollution and inflammatory/emostatic markers in midlife women. Epidemiology 27:211–20.
  • Grunig, G., L. M. Marsh, N. Esmaeil, K. Jackson, T. Gordon, J. Reibman, G. Kwapiszewska, and S. H. Park. 2014. Perspective: Ambient air pollution: Inflammatory response and effects on the lung’s vasculature. Pulm. Circ. 4:25–35. doi:10.1086/674902.
  • Guo, L., N. Zhu, Z. Guo, G. K. Li, C. Chen, N. Sang, and Q. C. Yao. 2012. Particulate matter (PM10) exposure induces endothelial dysfunction and inflammation in rat brain. J. Hazard. Mater. 213:28–37. doi:10.1016/j.jhazmat.2012.01.034.
  • Gurgueira, S. A., J. Lawrence, B. Coull, G. G. Murthy, and B. Gonzalez-Flecha. 2002. Rapid increases in the steady-state concentration of reactive oxygen species in the lungs and heart after particulate air pollution inhalation. Environ. Health Perspect. 110:749–55. doi:10.1289/ehp.02110749.
  • Hamanaka, R. B., and G. M. Mutlu. 2018. Particulate matter air pollution: Effects on the cardiovascular system. Front. Endocrinol. 9:600–80. doi:10.3389/fendo.2018.00680.
  • Hampel, R., A. Peters, R. Beelen, B. Brunekreef, J. Cyrys, U. de Faire, K. de Hoogh, K. Fuks, B. Hoffmann, A. Huls, et al., E. T. S. groups. 2015. Long-term effects of elemental composition of particulate matter on inflammatory blood markers in European cohorts Environ. Int. 82: 76–84. doi: 10.1016/j.envint.2015.05.008.
  • Hartz, A. M., B. Bauer, M. L. Block, J. S. Hong, and D. S. Miller. 2008. Diesel exhaust particles induce oxidative stress, proinflammatory signaling, and P-glycoprotein up-regulation at the blood-brain barrier. FASEB J. 22:2723–33. doi:10.1096/fj.08-106997.
  • Hassing, H. C., T. B. Twickler, J. J. Kastelein, M. J. Cramer, and F. R. Cassee. 2009. Air pollution as noxious environmental factor in the development of cardiovascular disease. Netherland J. Med. 67:116–21.
  • Hoffmann, B., S. Moebus, N. Dragano, A. Stang, S. Mohlenkamp, A. Schmermund, M. Memmesheimer, M. Brocker-Preuss, K. Mann, R. Erbel, et al.. 2009. Chronic residential exposure to particulate matter air pollution and systemic inflammatory markers. Environ. Health Perspect. 117:1302–08. doi:10.1289/ehp.0800362.
  • Huang, W., G. Wang, S. E. Lu, H. Kipen, Y. Wang, M. Hu, W. Lin, D. Rich, P. Ohman-Strickland, S. R. Diehl, et al.. 2012. Inflammatory and oxidative stress responses of healthy young adults to changes in air quality during the Beijing Olympics. Am. J. Respir. Crit. Care Med. 186:1150–59. doi:10.1164/rccm.201205-0850OC.
  • Huang, Y. C., and A. J. Ghio. 2006. Vascular effects of ambient pollutant particles and metals. Curr. Vasc. Pharm. 4:199–203. doi:10.2174/157016106777698351.
  • Huttunen, K., T. Siponen, I. Salonen, T. Yli-Tuomi, M. Aurela, H. Dufva, R. Hillamo, E. Linkola, J. Pekkanen, A. Pennanen, et al.. 2012. Low-level exposure to ambient particulate matter is associated with systemic inflammation in ischemic heart disease patients. Environ. Res. 116:44–51. doi:10.1016/j.envres.2012.04.004.
  • Initiative, I. S.-L. D. B. 2019. The impact of air pollution on deaths, disease burden, and life expectancy across the states of India: The Global Burden of Disease Study 2017. Lancet Planet Health 3:26–39. doi:10.1016/S2542-5196(18)30261-4.
  • Jantzen, K., A. Jensen, A. Kermanizadeh, G. Elholm, T. Sigsgaard, P. Moller, M. Roursgaard, and S. Loft. 2018. Inhalation of house dust and zone alters systemic levels of endothelial progenitor cells, oxidative stress, and inflammation in elderly subjects. Toxicol. Sci. 163:353–63. doi:10.1093/toxsci/kfy027.
  • Johannesson, S., E. M. Andersson, L. Stockfelt, L. Barregard, and G. Sallsten. 2014. Urban air pollution and effects on biomarkers of systemic inflammation and coagulation: A panel study in healthy adults. Inhal. Toxicol. 26:84–94. doi:10.3109/08958378.2013.856968.
  • Kaufman, J. D., S. D. Adar, R. G. Barr, M. Budoff, G. L. Burke, C. L. Curl, M. L. Daviglus, A. V. Diez Roux, A. J. Gassett, D. R. Jacobs Jr., et al.. 2016. Association between air pollution and coronary artery calcification within six metropolitan areas in the USA (the Multi-Ethnic Study of Atherosclerosis and Air Pollution): A longitudinal cohort study. Lancet 388:696–704. doi:10.1016/S0140-6736(16)00378-0.
  • Keebaugh, A. J., C. Sioutas, P. Pakbin, J. J. Schauer, L. B. Mendez, and M. T. Kleinman. 2015. Is atherosclerotic disease associated with organic components of ambient fine particles. Sci. Total Environ. 533:69–75. doi:10.1016/j.scitotenv.2015.06.048.
  • Kelly, F. J., and J. C. Fussell. 2015. Linking ambient particulate matter pollution effects with oxidative biology and immune responses. Ann. N. Y. Acad. Sci. 1340:84–94. doi:10.1111/nyas.12720.
  • Kirrane, E. F., T. J. Luben, A. Benson, E. O. Owens, J. D. Sacks, S. J. Dutton, M. Madden, and J. L. Nichols. 2019. A systematic review of cardiovascular responses associated with ambient black carbon and fine particulate matter. Environ. Int. 127:305–16. doi:10.1016/j.envint.2019.02.027.
  • Knuckles, T. L., A. K. Lund, S. N. Lucas, and M. J. Campen. 2008. Diesel exhaust exposure enhances venoconstriction via uncoupling of eNOS. Toxicol. Appl. Pharmacol. 230:346–51. doi:10.1016/j.taap.2008.03.010.
  • Krishnan, R. M., J. H. Sullivan, C. Carlsten, H. W. Wilkerson, R. P. Beyer, T. Bammler, F. Farin, A. Peretz, and J. D. Kaufman. 2013. A randomized cross-over study of inhalation of diesel exhaust, hematological indices, and endothelial markers in humans. Part Fibre Toxicol 10:3–70. doi:10.1186/1743-8977-10-7.
  • Kristovich, R., D. A. Knight, J. F. Long, M. V. Williams, P. K. Dutta, and W. J. Waldman. 2004. Macrophage-mediated endothelial inflammatory responses to airborne particulates: Impact of particulate physicochemical properties. Chem. Res. Toxicol. 17:1303–12. doi:10.1021/tx049893p.
  • Kunzli, N., L. Perez, S. von Klot, D. Baldassarre, M. Bauer, X. Basagana, C. Breton, J. Dratva, R. Elosua, U. de Faire, et al.. 2011. Investigating air pollution and atherosclerosis in humans: Concepts and outlook. Prog. Cardiovasc. Dis. 53:334–43.
  • Landrigan, P. J., R. Fuller, N. J. R. Acosta, O. Adeyi, R. Arnold, N. N. Basu, A. B. Balde, R. Bertollini, S. Bose-O’Reilly, J. I. Boufford, et al.. 2018. The Lancet Commission on pollution and health. Lancet 391:462–512. doi:10.1016/S0140-6736(17)32345-0.
  • Langrish, J. P., J. Bosson, J. Unosson, A. Muala, D. E. Newby, N. L. Mills, A. Blomberg, and T. Sandstrom. 2012. Cardiovascular effects of particulate air pollution exposure: Time course and underlying mechanisms. J. Intern. Med. 272:224–39. doi:10.1111/j.1365-2796.2012.02566.x.
  • Lanki, T., R. Hampel, P. Tiittanen, S. Andrich, R. Beelen, B. Brunekreef, J. Dratva, U. De Faire, K. B. Fuks, B. Hoffmann, et al.. 2015. Air pollution from road traffic and systemic inflammation in adults: A cross-sectional analysis in the European ESCAPE project. Environ. Health Perspect. 123:785–91. doi:10.1289/ehp.1408224.
  • Lawal, A. O. 2017. Air particulate matter induced oxidative stress and inflammation in cardiovascular disease and atherosclerosis: The role of Nrf2 and AhR-mediated pathways. Toxicol. Lett. 270:88–95. doi:10.1016/j.toxlet.2017.01.017.
  • LeBlanc, A. J., J. L. Cumpston, B. T. Chen, D. Frazer, V. Castranova, and T. R. Nurkiewicz. 2009. Nanoparticle inhalation impairs endothelium-dependent vasodilation in subepicardial arterioles. J. Toxicol. Environ. Health Part A 72:1576–84. doi:10.1080/15287390903232467.
  • Lee, C. C., S. H. Huang, Y. T. Yang, Y. W. Cheng, C. H. Li, and J. J. Kang. 2012. Motorcycle exhaust particles up-regulate expression of vascular adhesion molecule-1 and intercellular adhesion molecule-1 in human umbilical vein endothelial cells. Toxicol In Vitro 26:552–60. doi:10.1016/j.tiv.2012.01.021.
  • Lee, M. S., K. D. Eum, S. C. Fang, E. G. Rodrigues, G. A. Modest, and D. C. Christiani. 2014. Oxidative stress and systemic inflammation as modifiers of cardiac autonomic responses to particulate air pollution. Int. J. Cardiol. 176:166–70. doi:10.1016/j.ijcard.2014.07.012.
  • Lelieveld, J., K. Klingmuller, A. Pozzer, U. Poschl, M. Fnais, A. Daiber, and T. Munzel. 2019. Cardiovascular disease burden from ambient air pollution in Europe reassessed using novel hazard ratio functions. Eur. Heart J. 40:1590–96. doi:10.1093/eurheartj/ehz135.
  • Lenters, V., C. S. Uiterwaal, R. Beelen, M. L. Bots, P. Fischer, B. Brunekreef, and G. Hoek. 2010. Long-term exposure to air pollution and vascular damage in young adults. Epidemiology 21:512–20. doi:10.1097/EDE.0b013e3181dec3a7.
  • Li, H., J. Cai, R. Chen, Z. Zhao, Z. Ying, L. Wang, J. Chen, K. Hao, P. L. Kinney, H. Chen, et al.. 2017. Particulate matter exposure and stress hormone levels: A randomized, double-blind, crossover trial of air purification. Circulation 136:618–27. doi:10.1161/CIRCULATIONAHA.116.026796.
  • Li, R., M. Navab, P. Pakbin, Z. Ning, K. Navab, G. Hough, T. E. Morgan, C. E. Finch, J. A. Araujo, A. M. Fogelman, et al.. 2013. Ambient ultrafine particles alter lipid metabolism and HDL anti-oxidant capacity in LDLR-null mice. J. Lipid Res. 54:1608–15. doi:10.1194/jlr.M035014.
  • Li, X., K. Tang, X. R. Jin, Y. Xiang, J. Xu, L. L. Yang, N. Wang, Y. F. Li, A. L. Ji, L. X. Zhou, et al.. 2018. Short-term air pollution exposure is associated with hospital length of stay and hospitalization costs among inpatients with type 2 diabetes: A hospital-based study. J. Toxicol. Environ. Health Part A 81:819–29.
  • Lippmann, M. 2014. Toxicological and epidemiological studies of cardiovascular effects of ambient air fine particulate matter (PM2.5) and its chemical components: Coherence and public health implications. Crit. Rev. Toxicol. 44:299–347. doi:10.3109/10408444.2013.861796.
  • Liu, J., X. Ye, D. Ji, X. Zhou, C. Qiu, W. Liu, and L. Yu. 2018. Diesel exhaust inhalation exposure induces pulmonary arterial hypertension in mice. Environ. Pollut. 237:747–55. doi:10.1016/j.envpol.2017.10.121.
  • Liu, L., B. Urch, R. Poon, M. Szyszkowicz, M. Speck, D. R. Gold, A. J. Wheeler, J. A. Scott, J. R. Brook, P. S. Thorne, et al.. 2015. Effects of ambient coarse, fine, and ultrafine particles and their biological constituents on systemic biomarkers: A controlled human exposure study. Environ. Health Perspect. 123:534–40. doi:10.1289/ehp.1408387.
  • Louwies, T., L. I. Panis, M. Kicinski, P. De Boever, and T. S. Nawrot. 2013. Retinal microvascular responses to short-term changes in particulate air pollution in healthy adults. Environ. Health Perspect. 121:1011–16. doi:10.1289/ehp.1205721.
  • Luben, T. J., J. L. Nichols, S. J. Dutton, E. Kirrane, E. O. Owens, L. Datko-Williams, M. Madden, and J. D. Sacks. 2017. A systematic review of cardiovascular emergency department visits, hospital admissions and mortality associated with ambient black carbon. Environ. Int. 107:154–62. doi:10.1016/j.envint.2017.07.005.
  • Lund, A. K., T. L. Knuckles, C. Obot Akata, R. Shohet, J. D. McDonald, A. Gigliotti, J. C. Seagrave, and M. J. Campen. 2007. Gasoline exhaust emissions induce vascular remodeling pathways involved in atherosclerosis. Toxicol. Sci. 95:485–94. doi:10.1093/toxsci/kfl145.
  • Lund, A. K., J. Lucero, M. Harman, M. C. Madden, J. D. McDonald, J. C. Seagrave, and M. J. Campen. 2011. The oxidized low-density lipoprotein receptor mediates vascular effects of inhaled vehicle emissions. Am. J. Respir. Crit. Care Med. 184:82–91. doi:10.1164/rccm.201012-1967OC.
  • Lundback, M., N. L. Mills, A. Lucking, S. Barath, K. Donaldson, D. E. Newby, T. Sandstrom, and A. Blomberg. 2009. Experimental exposure to diesel exhaust increases arterial stiffness in man. Part Fibre Toxicol 6:17–71. doi:10.1186/1743-8977-6-7.
  • Martinelli, N., O. Olivieri, and D. Girelli. 2013. Air particulate matter and cardiovascular disease: A narrative review. Eur. J. Intern. Med. 24:295–302. doi:10.1016/j.ejim.2013.04.001.
  • Mehta, P. K., J. Wei, and N. K. Wenger. 2015. Ischemic heart disease in women: A focus on risk factors. Trends Cardiovasc. Med. 25:140–51. doi:10.1016/j.tcm.2014.10.005.
  • Meza, C. A., J. D. La Favor, D. H. Kim, and R. C. Hickner. 2019. Endothelial dysfunction: Is there a hyperglycemia-induced imbalance of NOX and NOS. Int. J. Mol. Sci. 20:14–39. doi:10.3390/ijms20153775.
  • Michikawa, T., T. Okamura, H. Nitta, Y. Nishiwaki, T. Takebayashi, K. Ueda, A. Kadota, A. Fujiyoshi, T. Ohkubo, H. Ueshima, et al.. 2016. Cross-sectional association between exposure to particulate matter and inflammatory markers in the Japanese general population: NIPPON DATA. Environ. Pollut. 213:460–67. doi:10.1016/j.envpol.2016.02.051.
  • Miller, M. R. 2014. The role of oxidative stress in the cardiovascular actions of particulate air pollution. Biochem. Soc. Trans. 42:1006–11. doi:10.1042/BST20140090.
  • Miller, M. R., S. J. Borthwick, C. A. Shaw, S. G. McLean, D. McClure, N. L. Mills, R. Duffin, K. Donaldson, I. L. Megson, P. W. Hadoke, et al.. 2009. Direct impairment of vascular function by diesel exhaust particulate through reduced bioavailability of endothelium-derived nitric oxide induced by superoxide free radicals. Environ. Health Perspect. 117:611–16. doi:10.1289/ehp.0800235.
  • Miller, M. R., S. G. McLean, R. Duffin, A. O. Lawal, J. A. Araujo, C. A. Shaw, N. L. Mills, K. Donaldson, D. E. Newby, and P. W. Hadoke. 2013. Diesel exhaust particulate increases the size and complexity of lesions in atherosclerotic mice. Part Fibre Toxicol 10:15–61. doi:10.1186/1743-8977-10-61.
  • Miller, M. R., J. B. Raftis, J. P. Langrish, S. G. McLean, P. Samutrtai, S. P. Connell, S. Wilson, A. T. Vesey, P. H. B. Fokkens, A. J. F. Boere, et al.. 2017. Inhaled nanoparticles accumulate at sites of vascular disease. ACS Nano. 11:4542–52. doi:10.1021/acsnano.6b08551.
  • Miller, M. R., C. A. Shaw, and J. P. Langrish. 2012. From particles to patients: Oxidative stress and the cardiovascular effects of air pollution. Future Cardiol 8:577–602. doi:10.2217/fca.12.43.
  • Mills, N. L., H. Tornqvist, S. D. Robinson, M. Gonzalez, K. Darnley, W. MacNee, N. A. Boon, K. Donaldson, A. Blomberg, T. Sandstrom, et al.. 2005. Diesel exhaust inhalation causes vascular dysfunction and impaired endogenous fibrinolysis. Circulation 112:3930–36. doi:10.1161/CIRCULATIONAHA.105.588962.
  • Mills, N. L., H. Tornqvist, S. D. Robinson, M. C. Gonzalez, S. Soderberg, T. Sandstrom, A. Blomberg, D. E. Newby, and K. Donaldson. 2007. Air pollution and atherothrombosis. Inhal. Toxicol. 19:81–89. doi:10.1080/08958370701495170.
  • Mirowsky, J. E., M. S. Carraway, R. Dhingra, H. Tong, L. Neas, D. Diaz-Sanchez, W. Cascio, M. Case, J. Crooks, E. R. Hauser, et al.. 2017. Ozone exposure is associated with acute changes in inflammation, fibrinolysis, and endothelial cell function in coronary artery disease patients. Environ. Health 16:45–126. doi:10.1186/s12940-017-0335-0.
  • Miyata, R., K. Hiraiwa, J. C. Cheng, N. Bai, R. Vincent, G. A. Francis, D. D. Sin, and S. F. Van Eeden. 2013. Statins attenuate the development of atherosclerosis and endothelial dysfunction induced by exposure to urban particulate matter (PM10). Toxicol. Appl. Pharmacol. 272:1–11. doi:10.1016/j.taap.2013.05.033.
  • Moller, P., D. V. Christophersen, N. R. Jacobsen, A. Skovmand, A. C. Gouveia, M. H. Andersen, A. Kermanizadeh, D. M. Jensen, P. H. Danielsen, M. Roursgaard, et al.. 2016. Atherosclerosis and vasomotor dysfunction in arteries of animals after exposure to combustion-derived particulate matter or nanomaterials. Crit. Rev. Toxicol. 46:437–76. doi:10.3109/10408444.2016.1149451.
  • Moller, P., L. Mikkelsen, L. K. Vesterdal, J. K. Folkmann, L. Forchhammer, M. Roursgaard, P. H. Danielsen, and S. Loft. 2011. Hazard identification of particulate matter on vasomotor dysfunction and progression of atherosclerosis. Crit. Rev. Toxicol. 41:339–68. doi:10.3109/10408444.2010.533152.
  • Morales-Barcenas, R., . Y. I., Y. Chirino, A. R. Sanchez-Perez, J. Osornio-Vargas, I. Melendez-Zajgla, C. M. Rosas And, and G. Cuellar. 2015. Particulate matter (PM10) induces metalloprotease activity and invasion in airway epithelial cells. Toxicol. Lett. 237:167–73.
  • Nasser, Z., P. Salameh, W. Nasser, L. Abou Abbas, E. Elias, and A. Leveque. 2015. Outdoor particulate matter (PM) and associated cardiovascular diseases in the Middle East. Int. J. Occup. Med. Environ Health 28:641–61. doi:10.13075/ijomeh.1896.00186.
  • Nelin, T. D., A. M. Joseph, M. W. Gorr, and L. E. Wold. 2012. Direct and indirect effects of particulate matter on the cardiovascular system. Toxicol. Lett. 208:293–99. doi:10.1016/j.toxlet.2011.11.008.
  • Newby, D. E., P. M. Mannucci, G. S. Tell, A. A. Baccarelli, R. D. Brook, K. Donaldson, F. Forastiere, M. Franchini, O. H. Franco, I. Graham, et al.. 2015. Expert position paper on air pollution and cardiovascular disease. Eur. Heart J. 36:83–93. doi:10.1093/eurheartj/ehu458.
  • Niu, J., E. N. Liberda, S. Qu, X. Guo, X. Li, J. Zhang, J. Meng, B. Yan, N. Li, M. Zhong, et al.. 2013. The role of metal components in the cardiovascular effects of PM2.5. PLoS. One 8:83–782. doi:10.1371/journal.pone.0083782.
  • Nogueira, J. B. 2009. Air pollution and cardiovascular disease. Rev. Port. Cardiol. 28:715–33.
  • Nurkiewicz, T. R., D. W. Porter, M. Barger, V. Castranova, and M. A. Boegehold. 2004. Particulate matter exposure impairs systemic microvascular endothelium-dependent dilation. Environ. Health Perspect. 112:1299–306. doi:10.1289/ehp.7001.
  • Nurkiewicz, T. R., D. W. Porter, M. Barger, L. Millecchia, K. M. Rao, P. J. Marvar, A. F. Hubbs, V. Castranova, and M. A. Boegehold. 2006. Systemic microvascular dysfunction and inflammation after pulmonary particulate matter exposure. Environ. Health Perspect. 114:412–19. doi:10.1289/ehp.8413.
  • O’Neill, M. S., A. Veves, J. A. Sarnat, A. Zanobetti, D. R. Gold, P. A. Economides, E. S. Horton, and J. Schwartz. 2007. Air pollution and inflammation in type 2 diabetes: A mechanism for susceptibility. Occup. Environ. Med. 64:373–79. doi:10.1136/oem.2006.030023.
  • O’Neill, M. S., A. Veves, A. Zanobetti, J. A. Sarnat, D. R. Gold, P. A. Economides, E. S. Horton, and J. Schwartz. 2005. Diabetes enhances vulnerability to particulate air pollution-associated impairment in vascular reactivity and endothelial function. Circulation 111:2913–20. doi:10.1161/CIRCULATIONAHA.104.517110.
  • Oppenheim, H. A., J. Lucero, A. C. Guyot, L. M. Herbert, J. D. McDonald, A. Mabondzo, and A. K. Lund. 2013. Exposure to vehicle emissions results in altered blood brain barrier permeability and expression of matrix metalloproteinases and tight junction proteins in mice. Part Fibre Toxicol 10:1–62. doi:10.1186/1743-8977-10-62.
  • Peretz, A., J. H. Sullivan, D. F. Leotta, C. A. Trenga, F. N. Sands, J. Allen, C. Carlsten, C. W. Wilkinson, E. A. Gill, and J. D. Kaufman. 2008. Diesel exhaust inhalation elicits acute vasoconstriction in vivo. Environ. Health Perspect. 116:937–42. doi:10.1289/ehp.11027.
  • Pinichka, C., N. Makka, D. Sukkumnoed, S. Chariyalertsak, P. Inchai, and K. Bundhamcharoen. 2017. Burden of disease attributed to ambient air pollution in Thailand: A GIS-based approach. PLoS. One 12:189–909. doi:10.1371/journal.pone.0189909.
  • Polichetti, G., S. Cocco, A. Spinali, V. Trimarco, and A. Nunziata. 2009. Effects of particulate matter PM(10), PM(2.5) and PM(1) on the cardiovascular system. Toxicology 261:1–8. doi:10.1016/j.tox.2009.04.035.
  • Pope, C. A., 3rd, A. Bhatnagar, J. P. McCracken, W. Abplanalp, D. J. Conklin, and T. O’Toole. 2016. Exposure to fine particulate air pollution is associated with endothelial injury and systemic inflammation. Circ. Res. 119:1204–14. doi:10.1161/CIRCRESAHA.116.309279.
  • Pope, C. A., 3rd, R. T. Burnett, M. J. Thun, E. E. Calle, D. Krewski, K. Ito, and G. D. Thurston. 2002. Lung cancer, cardiopulmonary mortality, and long-term exposure to fine particulate air pollution. J. Am. Med. Assoc. 287:1132–41. doi:10.1001/jama.287.9.1132.
  • Pope, C. A., 3rd, J. C. Hansen, R. Kuprov, M. D. Sanders, M. N. Anderson, and D. J. Eatough. 2011. Vascular function and short-term exposure to fine particulate air pollution. J. Air Waste Manage. Assoc. 61:858–63. doi:10.3155/1047-3289.61.8.858.
  • Premasekharan, G., K. Nguyen, J. Contreras, V. Ramon, V. J. Leppert, and H. J. Forman. 2011. Iron-mediated lipid peroxidation and lipid raft disruption in low-dose silica-induced macrophage cytokine production. Free Radic. Biol. Med. 51:1184–94. doi:10.1016/j.freeradbiomed.2011.06.018.
  • Prueitt, R. L., J. M. Cohen, and J. E. Goodman. 2015. Evaluation of atherosclerosis as a potential mode of action for cardiovascular effects of particulate matter. Regul. Toxicol. Pharmacol. 73:1–15. doi:10.1016/j.yrtph.2015.09.034.
  • Rajagopalan, S., S. G. Al-Kindi, and R. D. Brook. 2018. Air pollution and cardiovascular disease: JACC state-of-the-art review. J. Am. Coll. Cardiol. 72:2054–70. doi:10.1016/j.jacc.2018.07.099.
  • Ramanathan, G., F. Yin, M. Speck, C. H. Tseng, J. R. Brook, F. Silverman, B. Urch, R. D. Brook, and J. A. Araujo. 2016. Effects of urban fine particulate matter and ozone on HDL functionality. Part Fibre Toxicol 13:1–26.
  • Rao, X., J. Zhong, A. Maiseyeu, B. Gopalakrishnan, F. A. Villamena, L. C. Chen, J. R. Harkema, Q. Sun, and S. Rajagopalan. 2014. CD36-dependent 7-ketocholesterol accumulation in macrophages mediates progression of atherosclerosis in response to chronic air pollution exposure. Circ. Res. 115:770–80. doi:10.1161/CIRCRESAHA.115.304666.
  • Rask-Madsen, C., and G. L. King. 2013. Vascular complications of diabetes: Mechanisms of injury and protective factors. Cell Metab. 17:20–33. doi:10.1016/j.cmet.2012.11.012.
  • Rich, D. Q., H. M. Kipen, W. Huang, G. Wang, Y. Wang, P. Zhu, P. Ohman-Strickland, M. Hu, C. Philipp, S. R. Diehl, et al.. 2012. Association between changes in air pollution levels during the Beijing Olympics and biomarkers of inflammation and thrombosis in healthy young adults. J. Am. Med. Assoc. 307:2068–78. doi:10.1001/jama.2012.3488.
  • Robertson, S., G. A. Gray, R. Duffin, S. G. McLean, C. A. Shaw, P. W. Hadoke, D. E. Newby, and M. R. Miller. 2012. Diesel exhaust particulate induces pulmonary and systemic inflammation in rats without impairing endothelial function ex vivo or in vivo. Part Fibre Toxicol 9:1–9. doi:10.1186/1743-8977-9-9.
  • Rudez, G., N. A. Janssen, E. Kilinc, F. W. Leebeek, M. E. Gerlofs-Nijland, H. M. Spronk, H. Ten Cate, F. R. Cassee, and M. P. de Maat. 2009. Effects of ambient air pollution on hemostasis and inflammation. Environ. Health Perspect. 117:995–1001. doi:10.1289/ehp.0800437.
  • Rundell, K. W., J. R. Hoffman, R. Caviston, R. Bulbulian, and A. M. Hollenbach. 2007. Inhalation of ultrafine and fine particulate matter disrupts systemic vascular function. Inhal. Toxicol. 19:133–40. doi:10.1080/08958370601051727.
  • Sandhu, R. S., D. H. Petroni, and W. J. George. 2005. Ambient particulate matter, C-reactive protein, and coronary artery disease. Inhal. Toxicol. 17:409–13. doi:10.1080/08958370590929538.
  • Saura, M., C. Zaragoza, C. Bao, B. Herranz, M. Rodriguez-Puyol, and C. J. Lowenstein. 2006. Stat3 mediates interleukin-6 [correction of interelukin-6] inhibition of human endothelial nitric-oxide synthase expression. J. Biol. Chem. 281:30057–62. doi:10.1074/jbc.M606279200.
  • Scapellato, M. L., and M. Lotti. 2007. Short-term effects of particulate matter: An inflammatory mechanism. Crit. Rev. Toxicol. 37:461–87.
  • Schisler, J. C., S. M. Ronnebaum, M. Madden, M. Channell, M. Campen, and M. S. Willis. 2015. Endothelial inflammatory transcriptional responses to an altered plasma exposome following inhalation of diesel emissions. Inhal. Toxicol. 27:272–80. doi:10.3109/08958378.2015.1030481.
  • Schroeder, W. H., M. Dobson, D. M. Kane, and N. D. Johnson. 1987. Toxic trace elements associated with airborne particulate matter: A review. J. Air Pollut. Control Assoc. 37:1267–85.
  • See, S. W., Y. H. Wang, and R. Balasubramanian. 2007. Contrasting reactive oxygen species and transition metal concentrations in combustion aerosols. Environ. Res. 103:317–24. doi:10.1016/j.envres.2006.08.012.
  • Shrey, K., A. Suchit, D. Deepika, K. Shruti, and R. Vibha. 2011. Air pollutants: The key stages in the pathway towards the development of cardiovascular disorders. Environ. Toxicol. Pharmacol. 31:1–9. doi:10.1016/j.etap.2010.09.002.
  • Simkhovich, B. Z., M. T. Kleinman, and R. A. Kloner. 2008. Air pollution and cardiovascular injury epidemiology, toxicology, and mechanisms. J. Am. Coll. Cardiol. 52:719–26. doi:10.1016/j.jacc.2008.05.029.
  • Siponen, T., T. Yli-Tuomi, M. Aurela, H. Dufva, R. Hillamo, M. R. Hirvonen, K. Huttunen, J. Pekkanen, A. Pennanen, I. Salonen, et al.. 2015. Source-specific fine particulate air pollution and systemic inflammation in ischemic heart disease patients. Occup. Environ. Med. 72:277–83. doi:10.1136/oemed-2014-102240.
  • Su, T. C., J. J. Hwang, Y. C. Shen, and C. C. Chan. 2015. Carotid intima-media thickness and long-term exposure to traffic-related air pollution in middle-aged residents of Taiwan: A cross-sectional study. Environ. Health Perspect. 123:773–78. doi:10.1289/ehp.1408553.
  • Sun, Q., X. Hong, and L. E. Wold. 2010. Cardiovascular effects of ambient particulate air pollution exposure. Circulation 121:2755–65. doi:10.1161/CIRCULATIONAHA.109.893461.
  • Sun, Q., A. Wang, X. Jin, A. Natanzon, D. Duquaine, R. D. Brook, J. G. Aguinaldo, Z. A. Fayad, V. Fuster, M. Lippmann, et al.. 2005. Long-term air pollution exposure and acceleration of atherosclerosis and vascular inflammation in an animal model. J. Am. Med. Ass. 294:3003–10. doi:10.1001/jama.294.23.3003.
  • Sun, Q., P. Yue, R. I. Kirk, A. Wang, D. Moatti, X. Jin, B. Lu, A. D. Schecter, M. Lippmann, T. Gordon, et al.. 2008a. Ambient air particulate matter exposure and tissue factor expression in atherosclerosis. Inhal. Toxicol. 20:127–37. doi:10.1080/08958370701821482.
  • Sun, Q., P. Yue, Z. Ying, A. J. Cardounel, R. D. Brook, R. Devlin, J. S. Hwang, J. L. Zweier, L. C. Chen, and S. Rajagopalan. 2008b. Air pollution exposure potentiates hypertension through reactive oxygen species-mediated activation of Rho/ROCK. Arterioscler. Thromb. Vasc. Biol. 28:1760–66. doi:10.1161/ATVBAHA.108.166967.
  • Tamagawa, E., N. Bai, K. Morimoto, C. Gray, T. Mui, K. Yatera, X. Zhang, L. Xing, Y. Li, I. Laher, et al.. 2008. Particulate matter exposure induces persistent lung inflammation and endothelial dysfunction. Am. J. Physiol. Lung Cell Mol. Physiol. 295:L79–L85. doi:10.1152/ajplung.00048.2007.
  • Taniyama, Y., and K. K. Griendling. 2003. Reactive oxygen species in the vasculature: Molecular and cellular mechanisms. Hypertension 42:1075–81. doi:10.1161/01.HYP.0000100443.09293.4F.
  • Tornqvist, H., N. L. Mills, M. Gonzalez, M. R. Miller, S. D. Robinson, I. L. Megson, W. Macnee, K. Donaldson, S. Soderberg, D. E. Newby, et al.. 2007. Persistent endothelial dysfunction in humans after diesel exhaust inhalation. Am. J. Respir. Crit. Care Med. 176:395–400. doi:10.1164/rccm.200606-872OC.
  • Toth, P. P., P. J. Barter, R. S. Rosenson, W. E. Boden, M. J. Chapman, M. Cuchel, R. B. D’Agostino Sr., M. H. Davidson, W. S. Davidson, J. W. Heinecke, et al.. 2013. High-density lipoproteins: A consensus statement from the National Lipid Association. J. Clin. Lipidol 7:484–525. doi:10.1016/j.jacl.2013.08.001.
  • Tranfield, E. M., S. F. van Eeden, K. Yatera, J. C. Hogg, and D. C. Walker. 2010. Ultrastructural changes in atherosclerotic plaques following the instillation of airborne particulate matter into the lungs of rabbits. Can. J. Cardiol 26:258–69. doi:10.1016/S0828-282X(10)70422-0.
  • Tsai, D. H., N. Amyai, P. Marques-Vidal, J. L. Wang, M. Riediker, V. Mooser, F. Paccaud, G. Waeber, P. Vollenweider, and M. Bochud. 2012. Effects of particulate matter on inflammatory markers in the general adult population. Part Fibre Toxicol 9:1–24. doi:10.1186/1743-8977-9-24.
  • Tsai, S. S., C. C. Chen, and C. Y. Yang. 2014. Short-term effect of fine particulate air pollution on daily mortality: A case-crossover study in a tropical city, Kaohsiung, Taiwan. J. Toxicol. Environ. Health Part A 77:467–77. doi:10.1080/15287394.2014.881247.
  • Utell, M. J., M. W. Frampton, W. Zareba, R. B. Devlin, and W. E. Cascio. 2002. Cardiovascular effects associated with air pollution: Potential mechanisms and methods of testing. Inhal. Toxicol. 14:1231–47. doi:10.1080/08958370290084881.
  • van Eeden, S. F., W. C. Tan, T. Suwa, H. Mukae, T. Terashima, T. Fujii, D. Qui, R. Vincent, and J. C. Hogg. 2001. Cytokines involved in the systemic inflammatory response induced by exposure to particulate matter air pollutants (PM10). Am. J. Respir. Crit. Care Med. 164:826–30. doi:10.1164/ajrccm.164.5.2010160.
  • Vidale, S., and C. Campana. 2018. Ambient air pollution and cardiovascular diseases: From bench to bedside. Eur. J. Prev. Cardiol. 25:818–25. doi:10.1177/2047487318766638.
  • Viehmann, A., S. Hertel, K. Fuks, L. Eisele, S. Moebus, S. Mohlenkamp, M. Nonnemacher, H. Jakobs, R. Erbel, K. H. Jockel, et al.. 2015. Long-term residential exposure to urban air pollution, and repeated measures of systemic blood markers of inflammation and coagulation. Occup. Environ. Med. 72:656–63.
  • Vodonos, A., Y. A. Awad, and J. Schwartz. 2018. The concentration-response between long-term PM2.5 exposure and mortality; A meta-regression approach. Environ. Res. 166:677–89. doi:10.1016/j.envres.2018.06.021.
  • Wang, G., R. Jiang, Z. Zhao, and W. Song. 2013. Effects of ozone and fine particulate matter (PM2.5) on rat system inflammation and cardiac function. Toxicol. Lett. 217:23–33. doi:10.1016/j.toxlet.2012.11.009.
  • Wang, M., S. Zheng, Y. Nie, J. Weng, N. Cheng, X. Hu, X. Ren, H. Pei, and Y. Bai. 2018. Association between short-term exposure to air pollution and dyslipidemias among type 2 diabetic patients in northwest China: A population-based study. Int. J. Environ. Res. Public Health 15:576–615.
  • Wang, T., L. Wang, L. Moreno-Vinasco, G. D. Lang, J. H. Siegler, B. Mathew, P. V. Usatyuk, J. M. Samet, A. S. Geyh, P. N. Breysse, et al.. 2012. Particulate matter air pollution disrupts endothelial cell barrier via calpain-mediated tight junction protein degradation. Part Fibre Toxicol 9:1–35. doi:10.1186/1743-8977-9-35.
  • Wang, Y., G. A. Wellenius, D. A. Hickson, A. Gjelsvik, C. B. Eaton, and S. B. Wyatt. 2016. Residential proximity to traffic-related pollution and atherosclerosis in 4 vascular beds among African American adults: Results from the Jackson Heart Study. Am. J. Epidemiol. 184:732–43. doi:10.1093/aje/kww080.
  • Wang, Y., L. Xiong, and M. Tang. 2017. Toxicity of inhaled particulate matter on the central nervous system: Neuroinflammation, neuropsychological effects and neurodegenerative disease. J. Appl. Toxicol. 37:644–67. doi:10.1002/jat.3451.
  • Watkinson, W. P., M. J. Campen, J. P. Nolan, and D. L. Costa. 2001. Cardiovascular and systemic responses to inhaled pollutants in rodents: Effects of ozone and particulate matter. Environ. Health Perspect. 109:539–46.
  • Wauters, A., C. Dreyfuss, S. Pochet, P. Hendrick, G. Berkenboom, P. van de Borne, and J. F. Argacha. 2013. Acute exposure to diesel exhaust impairs nitric oxide-mediated endothelial vasomotor function by increasing endothelial oxidative stress. Hypertension 62:352–58. doi:10.1161/HYPERTENSIONAHA.111.00991.
  • Wauters, A., M. Vicenzi, B. De Becker, J. P. Riga, F. Esmaeilzadeh, V. Faoro, J. L. Vachiery, P. van de Borne, and J. F. Argacha. 2015. At high cardiac output, diesel exhaust exposure increases pulmonary vascular resistance and decreases distensibility of pulmonary resistive vessels. Am. J. Physiol. Heart Circ. Physiol. 309:2137–44. doi:10.1152/ajpheart.00149.2015.
  • Wilker, E. H., M. A. Mittleman, B. A. Coull, A. Gryparis, M. L. Bots, J. Schwartz, and D. Sparrow. 2013. Long-term exposure to black carbon and carotid intima-media thickness: The normative aging study. Environ. Health Perspect. 121:1061–67. doi:10.1289/ehp.1104845.
  • Wolf, K., A. Popp, A. Schneider, S. Breitner, R. Hampel, W. Rathmann, C. Herder, M. Roden, W. Koenig, C. Meisinger, et al.. 2016. Association between long-term exposure to air pollution and biomarkers related to insulin resistance, subclinical inflammation, and adipokines. Diabetes 65:3314–26. doi:10.2337/db15-1567.
  • Yan, Z., Y. Jin, Z. An, Y. Liu, J. M. Samet, and W. Wu. 2016. Inflammatory cell signaling following exposures to particulate matter and ozone. Biochim. Biophys. Acta 1860:2826–34. doi:10.1016/j.bbagen.2016.03.030.
  • Yatera, K., J. Hsieh, J. C. Hogg, E. Tranfield, H. Suzuki, C. H. Shih, A. R. Behzad, R. Vincent, and S. F. van Eeden. 2008. Particulate matter air pollution exposure promotes recruitment of monocytes into atherosclerotic plaques. Am. J. Physiol. Heart Circ. Physiol. 294:944–53. doi:10.1152/ajpheart.00406.2007.
  • Ying, Z., T. Kampfrath, G. Thurston, B. Farrar, M. Lippmann, A. Wang, Q. Sun, L. C. Chen, and S. Rajagopalan. 2009. Ambient particulates alter vascular function through induction of reactive oxygen and nitrogen species. Toxicol. Sci. 111:80–88. doi:10.1093/toxsci/kfp004.
  • Yue, W., A. Schneider, M. Stolzel, R. Ruckerl, J. Cyrys, X. Pan, W. Zareba, W. Koenig, H. E. Wichmann, and A. Peters. 2007. Ambient source-specific particles are associated with prolonged repolarization and increased levels of inflammation in male coronary artery disease patients. Mutat. Res. 621:50–60. doi:10.1016/j.mrfmmm.2007.02.009.
  • Zanoli, L., P. Lentini, A. Granata, A. Gaudio, P. Fatuzzo, L. Serafino, S. Rastelli, V. Fiore, A. D’Anca, S. S. Signorelli, et al.. 2017. A systematic review of arterial stiffness, wave reflection and air pollution. Mol. Med. Rep. 15:3425–29.
  • Zhang, X., N. Staimer, D. L. Gillen, T. Tjoa, J. J. Schauer, M. M. Shafer, S. Hasheminassab, P. Pakbin, N. D. Vaziri, C. Sioutas, et al.. 2016a. Associations of oxidative stress and inflammatory biomarkers with chemically characterized air pollutant exposures in an elderly cohort. Environ. Res. 150:306–19. doi:10.1016/j.envres.2016.06.019.
  • Zhang, X., N. Staimer, T. Tjoa, D. L. Gillen, J. J. Schauer, M. M. Shafer, S. Hasheminassab, P. Pakbin, J. Longhurst, C. Sioutas, et al.. 2016b. Associations between microvascular function and short-term exposure to traffic-related air pollution and particulate matter oxidative potential. Environ. Health 15:3–81. doi:10.1186/s12940-016-0157-5.
  • Zou, Y., C. Jin, Y. Su, J. Li, and B. Zhu. 2016. Water soluble and insoluble components of urban PM2.5 and their cytotoxic effects on epithelial cells (A549) in vitro. Environ. Pollut. 212:627–35. doi:10.1016/j.envpol.2016.03.022.

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