Potential protective roles of curcumin against cadmium-induced toxicity and oxidative stress

References

• Abu-Taweel, G. M. 2016. Effects of curcumin on the social behavior, blood composition, reproductive hormones in plasma and brain acetylcholinesterase in cadmium intoxicated mice. Saudi J. Biol. Sci 23 (2):219–28. doi:10.1016/j.sjbs.2015.05.010.
   PubMed Web of Science ®Google Scholar
• Abu-Taweel, G. M., J. S. Ajarem, and M. Ahmad. 2013. Protective effect of curcumin on anxiety, learning behavior, neuromuscular activities, brain neurotransmitters and oxidative stress enzymes in cadmium intoxicated mice. J. Behav. Brain Sci 3 (01):74–84. doi:10.4236/jbbs.2013.31008.
   Google Scholar
• Aggarwal, M. L., K. M. Chacko, and B. T. Kuruvilla. 2016. Systematic and comprehensive investigation of the toxicity of curcuminoid -essential oil complex: A bioavailable turmeric formulation. Mol. Med. Rep 13 (1):592–604. doi:10.3892/mmr.2015.4579.
   PubMed Web of Science ®Google Scholar
• Aggarwal, S., Y. Takada, S. Singh, J. N. Myers, and B. B. Aggarwal. 2004. Inhibition of growth and survival of human head and neck squamous cell carcinoma cells by curcumin via modulation of nuclear factor-kappaB signaling. Int. J. Cancer 111 (5):679–92. doi:10.1002/ijc.20333.
   PubMed Web of Science ®Google Scholar
• Akinyemi, A. J., N. Onyebueke, O. A. Faboya, S. A. Onikanni, A. Fadaka, and I. Olayide. 2017b. Curcumin inhibits adenosine deaminase and arginase activities in cadmium-induced renal toxicity in rat kidney. J. Food Drug Anal 25 (2):438–46. doi:10.1016/j.jfda.2016.06.004.
   PubMed Web of Science ®Google Scholar
• Akinyemi, A. J., P. K. Okonkwo, O. A. Faboya, S. A. Onikanni, A. Fadaka, I. Olayide, E. O. Akinyemi, and G. Oboh. 2017a. Curcumin improves episodic memory in cadmium induced memory impairment through inhibition of acetylcholinesterase and adenosine deaminase activities in a rat model. Metabolic Brain Disease 32 (1):87–95. doi:10.1007/s11011-016-9887-x.
   PubMed Web of Science ®Google Scholar
• Aktas, C., M. Kanter, M. Erboga, and S. Ozturk. 2012. Anti-apoptotic effects of curcumin on cadmium-induced apoptosis in rat testes. Toxicol. Ind. Health 28 (2):122–30. doi:10.1177/0748233711407242.
   PubMed Web of Science ®Google Scholar
• Alghasham, A., T. A. Salem, and A.-R. M. Meki. 2013. Effect of cadmium-polluted water on plasma levels of tumor necrosis factor-α, interleukin-6 and oxidative status biomarkers in rats: Protective effect of curcumin. Food and Chemical Toxicology 59:160–64. doi:10.1016/j.fct.2013.05.059.
   PubMed Web of Science ®Google Scholar
• Al-Gnami, S. A. 2014. Effect of polyphenols which extracted from green tea reduce toxic effects of cadmium sulfate in rat’s livers. IOSR. J.Pharm. Biol. Sci 9:53–58. doi:10.9790/3008-09275358.
   Google Scholar
• Alizadeh, M., and S. Kheirouri. 2019. Curcumin reduces malondialdehyde and improves antioxidants in humans with diseased conditions: A comprehensive meta-analysis of randomized controlled trials. Biomedicine (Taipei) 9 (4):23. doi:10.1051/bmdcn/2019090423.
   PubMedGoogle Scholar
• Al-Nasser, I. A. 2000. Cadmium hepatotoxicity and alterations of the mitochondrial function. J. Toxicol. Clin. Toxicol 38 (4):407–13. doi:10.1081/clt-100100950.
   PubMed Web of Science ®Google Scholar
• Alwi, I., T. Santoso, S. Suyono, B. Sutrisna, F. D. Suyatna, S. B. Kresno, and S. Ernie. 2008. The effect of curcumin on lipid level in patients with acute coronary syndrome. Acta Med. Indones 40:201–10.
   PubMedGoogle Scholar
• Anand, P., A. B. Kunnumakkara, R. A. Newman, and B. B. Aggarwal. 2007. Bioavailability of curcumin: Problems and promises. Mol. Pharm 4 (6):807–18. doi:10.1021/mp700113r.
   PubMed Web of Science ®Google Scholar
• Anand, P., C. Sundaram, S. Jhurani, A. B. Kunnumakkara, and B. B. Aggarwal. 2008. Curcumin and cancer: An “old-age” disease with an “age-old” solution. Cancer Lett. 267 (1):133–64. doi:10.1016/j.canlet.2008.03.025.
   PubMed Web of Science ®Google Scholar
• Aranami, F., H. Segawa, J. Furutani, S. Kuwahara, R. Tominaga, E. Hanabusa, S. Tatsumi, S. Kido, M. Ito, and K. Miyamoto. 2010. Fibroblast growth factor 23 mediates the phosphaturic actions of cadmium. J. Med. Invest 57 (1,2):95–108. doi:10.2152/jmi.57.95.
   PubMedGoogle Scholar
• Araujo, M., and W. J. Welch. 2006. Oxidative stress and nitric oxide in kidney function. Curr. Opin. Nephrol. Hypertens 15 (1):72–77. doi:10.1097/01.mnh.0000191912.65281.e9.
   PubMed Web of Science ®Google Scholar
• Arroyo, V. S., K. M. Flores, L. B. Ortiz, L. E. Gómez-Quiroz, and M. C. Gutiérrez-Ruiz. 2012. Liver and cadmium toxicity. J. Drug Metab. Toxicol 5 (001). doi: 10.4172/2157-7609.S5-001.
   Google Scholar
• Bakka, A., J. Aaseth, and H. E. Rugstad. 1981. Influence of certain chelating agents on egress of cadmium from cultured epithelial cells containing high amounts of metallothionein: A screening of Cd-releasing and toxic effects. Acta Pharmacol. Toxicol 49 (5):432–37. doi:10.1111/j.1600-0773.1981.tb00928.x.
   PubMedGoogle Scholar
• Bal, W., and K. S. Kasprzak. 2002. Induction of oxidative DNA damage by carcinogenic metals. Toxicol. Lett 127 (1–3):55–62. doi:10.1016/S0378-4274(01)00483-0.
   PubMed Web of Science ®Google Scholar
• Balogun, E., M. Hoque, P. Gong, E. Killeen, C. J. Green, R. Foresti, J. Alam, and R. Motterlini. 2003. Curcumin activates the haem oxygenase-1 gene via regulation of Nrf2 and the antioxidant-responsive element. Biochemical Journal 371 (3):887–95. doi:10.1042/BJ20021619.
   PubMedGoogle Scholar
• Barbee, J. Y., Jr., and T. S. Prince. 1999. Acute respiratory distress syndrome in a welder exposed to metal fumes. South. Med. J 92 (5):510–12. doi:10.1097/00007611-199905000-00012.
   PubMed Web of Science ®Google Scholar
• Basnet, P., and N. Skalko-Basnet. 2011. Curcumin: An anti-inflammatory molecule from a curry spice on the path to cancer treatment. Molecules 16 (6):4567–98. doi:10.3390/molecules16064567.
   PubMed Web of Science ®Google Scholar
• Bernhoft, R. A. 2013. Cadmium toxicity and treatment. Sci World J 2013:394652. doi:10.1155/2013/394652.
   Web of Science ®Google Scholar
• Bertin, G., and D. Averbeck. 2006. Cadmium: Cellular effects, modifications of biomolecules, modulation of DNA repair and genotoxic consequences (a review). Biochimie 88 (11):1549–59. doi:10.1016/j.biochi.2006.10.001.
   PubMed Web of Science ®Google Scholar
• Bhadauria, S., and S. J. S. Flora. 2007. Response of arsenic-induced oxidative stress, DNA damage and metal imbalance to combined administration of DMSA and monoisoamyl-DMSA during chronic arsenic poisoning in rats. Cell Biol. Toxicol 23 (2):91–104. doi:10.1007/s10565-006-0135-8.
   PubMed Web of Science ®Google Scholar
• Blum, J. L., J. R. Edwards, W. C. Prozialeck, J. Q. Xiong, and J. T. Zelikoff. 2015. Effects of maternal exposure to cadmium oxide nanoparticles during pregnancy on maternal and offspring kidney injury markers using a murine model. J. Toxicol. Environ. Health A 78 (12):711–24. doi:10.1080/15287394.2015.1026622.
   PubMed Web of Science ®Google Scholar
• Carageorgiou, H., V. Tzotzes, A. Sideris, A. Zarros, and S. Tsakiris. 2005. Cadmium effects on brain acetylcholinesterase activity and antioxidant status of adult rats: Modulation by zinc, calcium and L-cysteine co-administration. Basic Clin. Pharmacol. Toxicol 97:320–24. doi:10.1111/j.1742-7843.2005.pto_174.x.
   PubMed Web of Science ®Google Scholar
• Carroll, R. E., R. V. Benya, D. K. Turgeon, S. Vareed, M. Neuman, L. Rodriguez, M. Kakarala, P. M. Carpenter, C. McLaren, F. L. Meyskens Jr., et al. 2011. Phase IIa clinical trial of curcumin for the prevention of colorectal neoplasia. Cancer Prev. Res. (Phila) 4 (3):354–64. doi:10.1158/1940-6207.CAPR-10-0098.
   PubMed Web of Science ®Google Scholar
• Casalino, E., G. Calzaretti, C. Sblano, and C. Landriscina. 2002. Molecular inhibitory mechanisms of antioxidant enzymes in rat liver and kidney by cadmium. Toxicology 179 (1–2):37–50. doi:10.1016/s0300-483x(02)00245-7.
   PubMed Web of Science ®Google Scholar
• Chainoglou, E., and D. Hadjipavlou-Litina. 2019. Curcumin analogues and derivatives with anti-proliferative and anti-inflammatory activity: Structural characteristics and molecular targets. Expert Opin. Drug Discov 14 (8):821–42. doi:10.1080/17460441.2019.1614560.
   PubMed Web of Science ®Google Scholar
• Chandrasekaran, V. R. M., D.-Z. Hsu, and M.-Y. Liu. 2014. Beneficial effect of sesame oil on heavy metal toxicity. J. Parenter. Enteral Nutr 38 (2):179–85. doi:10.1177/0148607113490960.
   PubMed Web of Science ®Google Scholar
• Chater, S., T. Douki, C. Garrel, A. Favier, M. Sakly, and H. Abdelmelek. 2008. Cadmium-induced oxidative stress and DNA damage in kidney of pregnant female rats. C. R. Biol 331 (6):426–32. doi:10.1016/j.crvi.2008.03.009.
   PubMed Web of Science ®Google Scholar
• Chuengsamarn, S., S. Rattanamongkolgul, R. Luechapudiporn, C. Phisalaphong, and S. Jirawatnotai. 2012. Curcumin extract for prevention of type 2 diabetes. Diabetes Care 35 (11):2121–27. doi:10.2337/dc12-0116.
   PubMed Web of Science ®Google Scholar
• Cohly, H. H., A. Taylor, M. F. Angel, and A. K. Salahudeen. 1998. Effect of turmeric, turmerin and curcumin on H2O2-induced renal epithelial (LLC-PK1) cell injury. Free Radic. Biol. Med 24 (1):49–54. doi:10.1016/s0891-5849(97)00140-8.
   PubMed Web of Science ®Google Scholar
• Corveloni, A. C., S. C. Semprebon, A. Baranoski, B. I. Biazi, T. A. Zanetti, and M. S. Mantovani. 2020. Carnosic acid exhibits antiproliferative and proapoptotic effects in tumoral NCI-H460 and nontumoral IMR-90 cells. J. Toxicol. Environ. Health A 83:412–21.
   PubMed Web of Science ®Google Scholar
• da Costa, P., J. F. Gonçalves, J. Baldissarelli, T. R. Mann, F. H. Abdalla, A. M. Fiorenza, M. M. da Rosa, F. B. Carvalho, J. M. Gutierres, C. M. de Andrade, et al. 2017. Curcumin attenuates memory deficits and the impairment of cholinergic and purinergic signaling in rats chronically exposed to cadmium. Environmental Toxicology 32 (1):70–83. doi:10.1002/tox.22213.
   PubMed Web of Science ®Google Scholar
• da Cunha Martins, A., Jr., M. F. H. Carneiro, D. Grotto, J. A. Adeyemi, and F. Jr. Barbosa. 2018. Arsenic, cadmium, and mercury-induced hypertension: Mechanisms and epidemiological findings. J. Toxicol. Environ. Health B 21 (2):61–82. doi:10.1080/10937404.2018.1432025.
   PubMed Web of Science ®Google Scholar
• Daniel, S., J. L. Limson, A. Dairam, G. M. Watkins, and S. Daya. 2004. Through metal binding, curcumin protects against lead- and cadmium-induced lipid peroxidation in rat brain homogenates and against lead-induced tissue damage in rat brain. J. Inorg. Biochem 98 (2):266–75. doi:10.1016/j.jinorgbio.2003.10.014.
   PubMed Web of Science ®Google Scholar
• de Almeida Alvarenga, L., V. de Oliveira Leal, N. A. Borges, A. S. de Aguiar, G. Faxén-Irving, P. Stenvinkel, B. Lindhol, and D. Mafra. 2018. Curcumin - A promising nutritional strategy for chronic kidney disease patients. Journal of Functional Foods 40:715–21. doi:10.1016/j.jff.2017.12.015.
   Web of Science ®Google Scholar
• Deevika, B., S. Asha, G. Taju, and T. Nalini. 2012a. Cadmium acetate induced nephrotoxicity and protective role of curcumin in rats. Asian J. Pharm. Clin. Res 5:186–88.
   Google Scholar
• Deevika, B., S. Asha, G. Taju, and T. Nalini. 2012b. A study of cadmium acetate induced toxicity and hepatoprotective activities of curcumin in albino rats. Int. J. Res. Pharma. Sci 3:436–40.
   Google Scholar
• Dey, P., A. Kundu, H. J. Chakraborty, B. Kar, W. S. Choi, B. M. Lee, T. Bhakta, A. G. Atanasov, and H. S. Kim. 2019. Therapeutic value of steroidal alkaloids in cancer: Current trends and future perspectives. Int. J. Cancer 145 (7):1731–44. doi:10.1002/ijc.31965.
   PubMed Web of Science ®Google Scholar
• Dhillon, N., B. B. Aggarwal, R. A. Newman, R. A. Wolff, A. B. Kunnumakkara, J. L. Abbruzzese, C. S. Ng, V. Badmaev, and R. Kurzrock. 2008. Phase II trial of curcumin in patients with advanced pancreatic cancer. Clin. Cancer Res 14 (14):4491–99. doi:10.1158/1078-0432.CCR-08-0024.
   PubMed Web of Science ®Google Scholar
• Duvoix, A., R. Blasius, S. Delhalle, M. Schnekenburger, F. Morceau, E. Henry, M. Dicato, and M. Diederich. 2005. Chemopreventive and therapeutic effects of curcumin. Cancer Lett. 223 (2):181–90. doi:10.1016/j.canlet.2004.09.041.
   PubMed Web of Science ®Google Scholar
• Edwards, R. L., P. B. Luis, P. V. Varuzza, A. I. Joseph, S. H. Presley, R. Chaturvedi, and C. Schneider. 2017. The anti-inflammatory activity of curcumin is mediated by its oxidative metabolites. J. Biol. Chem 292 (52):21243–52. doi:10.1074/jbc.RA117.000123.
   PubMed Web of Science ®Google Scholar
• El-Habibi, E. M., A. M. El-Wakf, and A. Mogall. 2013. Efficacy of curcumin in reducing risk of cardiovascular disease in high fat diet-fed rats. J. Bioanal. Biomed 5 (03):66–70. doi:10.4172/1948-593X.1000082.
   Google Scholar
• Elinder, C. G., B. Lind, T. Kjellström, L. Linnman, and L. Friberg. 1976. Cadmium in kidney cortex, liver, and pancreas from Swedish autopsies. Estimation of biological half time in kidney cortex, considering calorie intake and smoking habits. Arch. Environ. Health 31 (6):292–302. doi:10.1080/00039896.1976.10667239.
   PubMed Web of Science ®Google Scholar
• El-Maraghy, S. A., M. Z. Gad, A. T. Fahim, and M. A. Hamdy. 2001. Effect of cadmium and aluminum intake on the antioxidant status and lipid peroxidation in rat tissues. J. Biochem. Mol. Toxicol 15 (4):207–14. doi:10.1002/jbt.18.
   PubMed Web of Science ®Google Scholar
• Epstein, J., I. R. Sanderson, and T. T. Macdonald. 2010. Curcumin as a therapeutic agent: The evidence from in vitro,animal and human studies. Br. J. Nutr 103 (11):1545–57. doi:10.1017/S0007114509993667.
   PubMed Web of Science ®Google Scholar
• Esrefoglu, M., M. Gül, B. Ates, and I. Yilmaz. 2006. Ultrastructural clues for the protective effect of ascorbic acid and N-acetylcysteine against oxidative damage on caerulein-induced pancreatitis. Pancreatology 6 (5):477–85. doi:10.1159/000094665.
   PubMed Web of Science ®Google Scholar
• Eybl, V., D. Kotyzová, and M. Bludovská. 2004. The effect of curcumin on cadmium-induced oxidative damage and trace elements level in the liver of rats and mice. Toxicology Letters 151 (1):79–85. doi:10.1016/j.toxlet.2004.02.019.
   PubMed Web of Science ®Google Scholar
• Ferrari, E., R. Benassi, S. Sacchi, F. Pignedoli, M. Asti, and M. Saladini. 2014. Curcumin derivatives as metal-chelating agents with potential multifunctional activity for pharmaceutical applications. J. Inorg. Biochem 139:38–48. doi:10.1016/j.jinorgbio.2014.06.002.
   PubMed Web of Science ®Google Scholar
• Flora, S. J. S., S. Bhadauria, V. Pachauri, and A. Yadav. 2012. Monoisoamyl 2, 3-dimercaptosuccinic acid (MiADMSA) demonstrates higher efficacy by oral route in reversing arsenic toxicity: A pharmacokinetic approach. Basic Clin. Pharmacol. Toxicol 110 (5):449–59. doi:10.1111/j.1742-7843.2011.00836.x.
   PubMed Web of Science ®Google Scholar
• Fowler, B. A. 2009. Monitoring of human populations for early markers of cadmium toxicity: A review. Toxicol. Appl. Pharmacol 238 (3):294–300. doi:10.1016/j.taap.2009.05.004.
   PubMed Web of Science ®Google Scholar
• Gangwar, R. K., V. A. Dhumale, D. Kumari, U. T. Nakate, S. W. Gosavi, R. B. Sharma, S. N. Kale, and S. Datar. 2012. Conjugation of curcumin with PVP capped gold nanoparticles for improving bioavailability. Mater. Sci. Eng. C 32 (8):2659–63. doi:10.1016/j.msec.2012.07.022.
   Web of Science ®Google Scholar
• García, J. D. D., and E. Arceo. 2018. Renal damage associated with heavy metals: Review work. Rev. Colomb. Nefrol 5:43–53. doi:10.22265/acnef.5.2.254.
   Google Scholar
• García-Niño, W. R., and J. Pedraza-Chaverrí. 2014. Protective effect of curcumin against heavy metals-induced liver damage. Food Chem. Toxicol 69:182–201. doi:10.1016/j.fct.2014.04.016.
   PubMed Web of Science ®Google Scholar
• Garrett, S. H., S. Somji, M. A. Sens, K. Zhang, and D. A. Sens. 2011. Microarray analysis of gene expression patterns in human proximal tubule cells over a short and long time course of cadmium exposure. J. Toxicol. Environ. Health A 74 (1):24–42. doi:10.1080/15287394.2010.514230.
   PubMed Web of Science ®Google Scholar
• Gilani, S. R., S. R. Ali Zaidi, M. Batool, A. A. Bhatti, A. I. Durrani, and Z. Mahmood. 2015. Report: Central nervous system (CNS) toxicity caused by metal poisoning: Brain as a target organ. Pak. J. Pharm. Sci 28:1417–23.
   PubMed Web of Science ®Google Scholar
• Ginsberg, G. L. 2012. Cadmium risk assessment in relation to background risk of chronic kidney disease. J. Toxicol. Environ. Health A 75 (7):374–90. doi:10.1080/15287394.2012.670895.
   PubMed Web of Science ®Google Scholar
• Godt, J., F. Scheidig, C. Grosse-Siestrup, V. Esche, P. Brandenburg, A. Reich, and D. A. Groneberg. 2006. The toxicity of cadmium and resulting hazards for human health. Journal of Occupational Medicine and Toxicology 1 (1):22. doi:10.1186/1745-6673-1-22.
   PubMedGoogle Scholar
• Gong, C., S. Deng, Q. Wu, M. Xiang, X. Wei, L. Li, X. Gao, B. Wang, L. Sun, Y. Chen, et al. 2013. Improving antiangiogenesis and anti-tumor activity of curcumin by biodegradable polymeric micelles. Biomaterials 34 (4):1413–32. doi:10.1016/j.biomaterials.2012.10.068.
   PubMed Web of Science ®Google Scholar
• Greten, F. R., C. K. Weber, T. F. Greten, G. Schneider, M. Wagner, G. Adler, and R. M. Schmid. 2002. Stat3 and NF-kappaB activation prevents apoptosis in pancreatic carcinogenesis. Gastroenterology 123 (6):2052–63. doi:10.1053/gast.2002.37075.
   PubMed Web of Science ®Google Scholar
• Grioni, S., C. Agnoli, V. Krogh, V. Pala, S. Rinaldi, M. Vinceti, P. Contiero, L. Vescovi, M. Malavolti, and S. Sieri. 2019. Dietary cadmium and risk of breast cancer subtypes defined by hormone receptor status: A prospective cohort study. Int. J. Cancer 144 (9):2153–60. doi:10.1002/ijc.32039.
   PubMed Web of Science ®Google Scholar
• Grose, E. C., J. H. Richards, R. H. Jaskot, M. G. Ménache, J. A. Graham, and W. C. Dauterman. 1987. A comparative study of the effects of inhaled cadmium chloride and cadmium oxide: Pulmonary response. J. Toxicol. Environ. Health 21 (1–2):219–32. doi:10.1080/15287398709531014.
   PubMed Web of Science ®Google Scholar
• Grynkiewicz, G., and P. Ślifirski. 2012. Curcumin and curcuminoids in quest for medicinal status. Acta Biochim. Pol 59 (2):201–12. doi:10.18388/abp.2012_2139.
   PubMed Web of Science ®Google Scholar
• Gupta, V. K., A. Kumar, N. J. Siddiqi, and B. Sharma. 2015. Rat brain acetyl cholinesterase as a biomarker of cadmium induced neurotoxicity. Open Access J. Toxicol 1 (555553). doi: 10.19080/OAJT.2016.01.555553.
   Google Scholar
• Habeebu, S. S., J. Liu, and C. D. Klaassen. 1998. Cadmium-induced apoptosis in mouse liver. Toxicol. Appl. Pharmacol 149 (2):203–09. doi:10.1006/taap.1997.8334.
   PubMed Web of Science ®Google Scholar
• Haines, D. D., I. Lekli, P. Teissier, I. Bak, and A. Tosaki. 2012. Role of haeme oxygenase-1 in resolution of oxidative stress-related pathologies: Focus on cardiovascular, lung, neurological and kidney disorders. Acta Physiologica 204 (4):487–501. doi:10.1111/j.1748-1716.2011.02387.x.
   PubMed Web of Science ®Google Scholar
• Hao, M. L., N. Pan, Q. H. Zhang, and X. H. Wang. 2015. Therapeutic efficacy of chlorogenic acid on cadmium-induced oxidative neuropathy in a murine model. Exp. Ther. Med 9 (5): 1887–94. doi:10.3892/etm.2015.2367
   Google Scholar
• Haque, S. K., G. Ariceta, and D. Batlle. 2012. Proximal renal tubular acidosis: A not so rare disorder of multiple etiologies. Nephrol. Dial. Transplant 27 (12):4273–87. doi:10.1093/ndt/gfs493.
   PubMed Web of Science ®Google Scholar
• Hassoun, E. A., and S. J. Stohs. 1996. Cadmium-induced production of superoxide anion and nitric oxide, DNA single strand breaks and lactate dehydrogenase leakage in J774A.1 cell cultures. Toxicology 112 (3):219–26. doi:10.1016/0300-483X(96)03404-X.
   PubMed Web of Science ®Google Scholar
• He, Y., Y. Yue, X. Zheng, K. Zhang, S. Chen, and Z. Du. 2015. Curcumin, inflammation, and chronic diseases: How are they linked? Molecules 20 (5):9183–213. doi:10.3390/molecules20059183.
   PubMed Web of Science ®Google Scholar
• He, Z.-Y., C.-B. Shi, H. Wen, F.-L. Li, B.-L. Wang, and J. Wang. 2011. Upregulation of p53 expression in patients with colorectal cancer by administration of curcumin. Cancer Invest. 29 (3):208–13. doi:10.3109/07357907.2010.550592.
   PubMed Web of Science ®Google Scholar
• Hellström, L., C. G. Elinder, B. Dahlberg, M. Lundberg, L. Järup, B. Persson, and O. Axelson. 2001. Cadmium exposure and end-stage renal disease. Am. J. Kidney Dis 38 (5):1001–08. doi:10.1053/ajkd.2001.28589.
   PubMed Web of Science ®Google Scholar
• Hewlings, S. J., and D. S. Kalman. 2017. Curcumin: A Review of Its Effects on Human Health. Foods 6 (10):92. doi:10.3390/foods6100092.
   PubMed Web of Science ®Google Scholar
• Holt, P. R., S. Katz, and R. Kirshoff. 2005. Curcumin therapy in inflammatory bowel disease: A pilot study. Dig. Dis. Sci 50 (11):2191–93. doi:10.1007/s10620-005-3032-8.
   PubMed Web of Science ®Google Scholar
• Horiguchi, H., K. Aoshima, E. Oguma, S. Sasaki, K. Miyamoto, Y. Hosoi, T. Katoh, and F. Kayama. 2010. Latest status of cadmium accumulation and its effects on kidneys, bone, and erythropoiesis in inhabitants of the formerly cadmium-polluted Jinzu River Basin in Toyama, Japan, after restoration of rice paddies. Int. Arch. Occup. Environ. Health 83 (8):953–70. doi:10.1007/s00420-010-0510-x.
   PubMed Web of Science ®Google Scholar
• Huang, M. T., T. Lysz, T. Ferraro, T. F. Abidi, J. D. Laskin, and A. H. Conney. 1991. Inhibitory effects of curcumin on in vitro lipoxygenase and cyclooxygenase activities in mouse epidermis. Cancer Res. 51:813–19.
   PubMed Web of Science ®Google Scholar
• Hyder, O., M. Chung, D. Cosgrove, J. M. Herman, Z. Li, A. Firoozmand, A. Gurakar, A. Koteish, and T. M. Pawlik. 2013. Cadmium exposure and liver disease among US adults. J. Gastrointest. Surg 17 (7):1265–73. doi:10.1007/s11605-013-2210-9.
   PubMed Web of Science ®Google Scholar
• Iavicoli, I., L. Fontana, and A. Bergamaschi. 2009. The effects of metals as endocrine disruptors. J. Toxicol. Environ. Health B 12 (3):206–23. doi:10.1080/10937400902902062.
   PubMed Web of Science ®Google Scholar
• Ibrahim, T. A., H. A. Tarboush, A. Alada, and M. A. Mohanna. 2014. The effect of selenium and lycopene on oxidative stress in bone tissue in rats exposed to cadmium. Food Nutr. Sci 5:1420–29. doi:10.4236/fns.2014.514155.
   Google Scholar
• Igra, A. M., M. Vahter, R. Raqib, and M. Kippler. 2019. Early-life cadmium exposure and bone-related biomarkers: A longitudinal study in children. Environ. Health Perspect 127 (3):37003. doi:10.1289/EHP3655.
   PubMed Web of Science ®Google Scholar
• Islam, M. T., E. S. Ali, S. J. Uddin, S. Shaw, M. A. Islam, M. I. Ahmed, M. C. Shill, U. K. Karmakar, N. S. Yarla, I. N. Khan, et al. 2018. Phytol: A review of biomedical activities. Food Chem. Toxicol 121:82–94. doi:10.1016/j.fct.2018.08.032.
   PubMed Web of Science ®Google Scholar
• Jain, S. K., J. Rains, J. Croad, B. Larson, and K. Jones. 2009. Curcumin supplementation lowers TNF-α, IL-6, IL-8, and MCP-1 secretion in high glucose-treated cultured monocytes and blood levels of TNF-α, IL-6, MCP-1, glucose, and glycosylated hemoglobin in diabetic rats. Antioxid. Redox Signal 11:241–49. doi:10.1089/ars.2008.2140.
   PubMed Web of Science ®Google Scholar
• Järup, L., and A. Akesson. 2009. Current status of cadmium as an environmental health problem. Toxicol. Appl. Pharmacol 238 (3):201–08. doi:10.1016/j.taap.2009.04.020.
   PubMed Web of Science ®Google Scholar
• Järup, L., M. Berglund, C. G. Elinder, G. Nordberg, and M. Vanter. 1998. Health effects of cadmium exposure–A review of the literature and a risk estimate. Scand. J. Work Environ. Health 24:1–51.
   PubMedGoogle Scholar
• Jayaprakasha, G. K., L. Jagan Mohan Rao, and K. K. Sakariah. 2005. Chemistry and biological activities of C. Longa. Trends Food Sci. Technol 16 (12):533–48. doi:10.1016/j.tifs.2005.08.006.
   Web of Science ®Google Scholar
• Jian, Y. T., G. F. Mai, J. D. Wang, Y. L. Zhang, R. C. Luo, and Y. X. Fang. 2005. Preventive and therapeutic effects of NF-κB inhibitor curcumin in rats colitis induced by trinitrobenzene sulfonic acid. World J. Gastroenterol 11 (12):1747–52. doi:10.3748/wjg.v11.i12.1747.
   PubMed Web of Science ®Google Scholar
• Jiang, A. J., G. Jiang, L. T. Li, and J. N. Zheng. 2015. Curcumin induces apoptosis through mitochondrial pathway and caspases activation in human melanoma cells. Mol. Biol. Rep 42 (1):267–75. doi:10.1007/s11033-014-3769-2.
   PubMed Web of Science ®Google Scholar
• Jin, T., M. Nordberg, W. Frech, X. Dumont, A. Bernard, T. T. Ye, Q. Kong, Z. Wang, P. Li, N. G. Lundstrom, et al. 2002. Cadmium biomonitoring and renal dysfunction among a population environmentally exposed to cadmium from smelting in China (ChinaCad). Biometals 15 (4):397–410. doi:10.1023/A:1020229923095.
   PubMed Web of Science ®Google Scholar
• Jobin, C., C. A. Bradham, M. P. Russo, B. Juma, A. S. Narula, D. A. Brenner, and R. B. Sartor. 1999. Curcumin blocks cytokine-mediated NF-κB activation and proinflammatory gene expression by inhibiting inhibitory factor I-κB kinase activity. J. Immunol 163:3474–83.
   PubMed Web of Science ®Google Scholar
• Joe, B., and B. R. Lokesh. 1994. Role of capsaicin, curcumin and dietary n-3 fatty acids in lowering the generation of reactive oxygen species in rat peritoneal macrophages. Biochim. Biophys. Acta 1224 (2):255–63. doi:10.1016/0167-4889(94)90198-8.
   PubMed Web of Science ®Google Scholar
• Joe, B., and B. R. Lokesh. 2000. Dietary n-3 fatty acids, curcumin and capsaicin lower the release of lysosomal enzymes and eicosanoids in rat peritoneal macrophages. Mol. Cell. Biochem 203 (1/2):153–61. doi:10.1023/a:1007005605869.
   PubMed Web of Science ®Google Scholar
• Joe, B., M. Vijaykumar, and B. R. Lokesh. 2004. Biological properties of curcumin-cellular and molecular mechanisms of action. Crit. Rev. Food Sci. Nutr 44 (2):97–111. doi:10.1080/10408690490424702.
   PubMed Web of Science ®Google Scholar
• Johri, N., G. Jacquillet, and R. Unwin. 2010. Heavy metal poisoning: The effects of cadmium on the kidney. Biometals 23 (5):783–92. doi:10.1007/s10534-010-9328-y.
   PubMed Web of Science ®Google Scholar
• Jones, M. M., P. K. Singh, G. R. Gale, A. B. Smith, and L. M. Atkins. 1992. Cadmium mobilization in vivo by intraperitoneal or oral administration of monoalkyl esters of meso–2, 3–dimercaptosuccinic acid in the mouse. Pharmacol. Toxicol 70:336–43. doi:10.1111/j.1600-0773.1992.tb00483.x.
   PubMedGoogle Scholar
• Jurenka, J. S. 2009. Anti-inflammatory properties of curcumin, a major constituent of Curcuma longa: A review of preclinical and clinical research. Altern. Med. Rev 14:141–53.
   PubMed Web of Science ®Google Scholar
• Kang, M. Y., S. H. Cho, Y. H. Lim, J. C. Seo, and Y. C. Hong. 2013. Effects of environmental cadmium exposure on liver function in adults. Occup. Environ. Med 70 (4):268–73. doi:10.1136/oemed-2012-101063.
   PubMed Web of Science ®Google Scholar
• Kannan, G. M., and S. J. S. Flora. 2006. Combined administration of N-acetylcysteine and monoisoamyl DMSA on tissue oxidative stress during arsenic chelation therapy. Biol. Trace Elem. Res 110 (1):43–59. doi:10.1385/BTER:110:1:43.
   PubMed Web of Science ®Google Scholar
• Kapakos, G., V. Youreva, and A. K. Srivastava. 2012. Cardiovascular protection by curcumin: Molecular aspects. Indian J. Biochem. Biophys 49:306–15.
   PubMed Web of Science ®Google Scholar
• Karuna, D. S., P. Dey, S. Das, A. Kundu, and T. Bhakta. 2017. In vitro antioxidant activities of root extract of Asparagus racemosus Linn. J. Tradit. Complement. Med 8 (1):60–65. doi:10.1016/j.jtcme.2017.02.004.
   PubMedGoogle Scholar
• Kataranovski, M., D. Kataranovski, D. Savic, G. Jovcic, Z. Bogdanovic, and T. Jovanovic. 1998. Granulocyte and plasma cytokine activity in acute cadmium intoxication in rats. Physiol. Res 47:453–61.
   PubMed Web of Science ®Google Scholar
• Kazazis, C., N. G. Vallianou, A. Kollas, and A. Evangelopoulos. 2014. Curcumin and diabetes: Mechanisms of action and its anti-diabetic properties. Curr. Top. Nutraceutical Res 12:135–41.
   Web of Science ®Google Scholar
• Kim, K., M. M.Melough, T. M.Vance, H.Noh, S. I.Koo, and O. K.Chun. 2018. Dietary cadmium intake and sources in the US. Nutrients 11 (1):2. doi:10.3390/nu11010002.
   PubMed Web of Science ®Google Scholar
• Kim, K. S., H. J. Lim, J. S. Lim, J. Y. Son, J. Lee, B. M. Lee, S. C. Chang, and H. S. Kim. 2018. Curcumin ameliorates cadmium-induced nephrotoxicity in Sprague-Dawley rats. Food Chem. Toxicol 114:34–40. doi:10.1016/j.fct.2018.02.007.
   PubMed Web of Science ®Google Scholar
• Kjellström, T. 1992. Mechanism and epidemiology of bone effects of cadmium. IARC Sci. Publ 118:301–10.
   PubMedGoogle Scholar
• Kohli, K., J. Ali, M. J. Ansari, and Z. Raheman. 2005. Curcumin: A natural antiinflammatory agent. Indian J. Pharmacol 37 (3):141–47. doi:10.4103/0253-7613.16209.
   Google Scholar
• Kukongviriyapan, U., K. Apaijit, and V. Kukongviriyapan. 2016. Oxidative stress and cardiovascular dysfunction associated with cadmium exposure: Beneficial effects of curcumin and tetrahydrocurcumin. Tohoku J. Exp. Med 239 (1):25–38. doi:10.1620/tjem.239.25.
   PubMed Web of Science ®Google Scholar
• Kukongviriyapan, U., P. Pannangpetch, V. Kukongviriyapan, W. Donpunha, K. Sompamit, and P. Surawattanawan. 2014. Curcumin Protects against Cadmium-Induced Vascular Dysfunction, Hypertension and Tissue Cadmium Accumulation in Mice. Nutrients 6 (3):1194–208. doi:10.3390/nu6031194.
   PubMed Web of Science ®Google Scholar
• Kundu, A., P. Dey, P. Sarkar, S. Karmakar, I. H. Tae, K. S. Kim, J. H. Park, S. H. Lee, B. M. Lee, L. Renthlei, et al. 2019. Protective effects of Croton hookeri on streptozotocin-induced diabetic nephropathy. Food Chem. Toxicol 135:110873. doi:10.1016/j.fct.2019.110873.
   PubMed Web of Science ®Google Scholar
• Kuwabara, N., S. Tamada, T. Iwai, K. Teramoto, N. Kaneda, T. Yukimura, T. Nakatani, and K. Miura. 2006. Attenuation of renal fibrosis by curcumin in rat obstructive nephropathy. Urology 67 (2):440–46. doi:10.1016/j.urology.2005.09.028.
   PubMed Web of Science ®Google Scholar
• Lee, M. Y., and K. K. Griendling. 2008. Redox signaling, vascular function, and hypertension. Antioxidants & Redox Signaling 10 (6):1045–59. doi:10.1089/ars.2007.1986.
   PubMed Web of Science ®Google Scholar
• Lee, Y. K., E. Y. Park, S. Kim, J. Y. Son, T. H. Kim, W. G. Kang, T. C. Jeong, K. B. Kim, S. J. Kwack, J. Lee, et al. 2014. Evaluation of cadmium-induced nephrotoxicity using urinary metabolomic profiles in sprague-dawley male rats. J. Toxicol. Environ. Health A 77 (22–24):1384–98. doi:10.1080/15287394.2014.951755.
   PubMed Web of Science ®Google Scholar
• Li, M., T. Xia, C. S. Jiang, L. J. Li, J. L. Fu, and Z. C. Zhou. 2003. Cadmium directly induced the opening of membrane permeability pore of mitochondria which possibly involved in cadmium-triggered apoptosis. Toxicology 194 (1–2):19–33. doi:10.1016/s0300-483x(03)00327-5.
   PubMed Web of Science ®Google Scholar
• Li, S., W. Yuan, G. Deng, P. Wang, P. Yang, and B. B. Aggarwal. 2011. Chemical composition and product quality control of turmeric (Curcuma longa L. Pharm. Crop 2:28–54. doi:10.2174/2210290601102010028.
   Google Scholar
• Li, X., Y. Lu, Y. Sun, and Q. Zhang. 2015. Effect of curcumin on permeability of coronary artery and expression of related proteins in rat coronary atherosclerosis heart disease model. Int. J. Clin. Exp. Pathol 8:7247–53.
   PubMed Web of Science ®Google Scholar
• Liang, Y., L. Lei, J. Nilsson, H. Li, M. Nordberg, A. Bernard, G. F. Nordberg, I. A. Bergdahl, and T. Jin. 2012. Renal function after reduction in cadmium exposure: An 8-year follow-up of residents in cadmium-polluted areas. Environ. Health Perspect 120 (2):223–28. doi:10.1289/ehp.1103699.
   PubMed Web of Science ®Google Scholar
• Lin, C. C., H. Y. Lin, H. C. Chen, M. W. Yu, and M. H. Lee. 2009. Stability and characterisation of phospholipid-based curcumin-encapsulated microemulsions. Food Chem. 116 (4):923–28. doi:10.1016/j.foodchem.2009.03.052.
   Web of Science ®Google Scholar
• Lin, S. S., H. P. Huang, J. S. Yang, J. Y. Wu, T. C. Hsia, C. C. Lin, C. W. Lin, C. L. Kuo, W. Gibson Wood, and J. G. Chung. 2008. DNA damage and endoplasmic reticulum stress mediated curcumin-induced cell cycle arrest and apoptosis in human lung carcinoma A-549 cells through the activation caspases cascade- and mitochondrial-dependent pathway. Cancer Lett. 272 (1):77–90. doi:10.1016/j.canlet.2008.06.031.
   PubMed Web of Science ®Google Scholar
• Lin, Y. S., J. L. Caffrey, M. H. Chang, N. Dowling, and J. W. Lin. 2010. Cigarette smoking, cadmium exposure, and zinc intake on obstructive lung disorder. Respir. Res 11 (1):53. doi:10.1186/1465-9921-11-53.
   PubMedGoogle Scholar
• Liu, Z., H. Li, M. Soleimani, K. Girijashanker, J. M. Reed, L. He, T. P. Dalton, and D. W. Nebert. 2008. Cd2+ versus Zn2+ uptake by the ZIP8 HCO3−-dependent symporter: Kinetics, electrogenicity and trafficking. Biochem. Biophys. Res. Commun 365 (4):814–20. doi:10.1016/j.bbrc.2007.11.067.
   PubMed Web of Science ®Google Scholar
• Mahmood, K., K. M. Zia, M. Zuber, M. Salman, and M. N. Anjum. 2015. Recent developments in curcumin and curcumin based polymeric materials for biomedical applications: A review. Int. J. Biol. Macromol 81:877–90. doi:10.1016/j.ijbiomac.2015.09.026.
   PubMed Web of Science ®Google Scholar
• Manca, D., A. C. Ricard, H. V. Tra, and G. Chevalier. 1994. Relation between lipid peroxidation and inflammation in the pulmonary toxicity of cadmium. Arch. Toxicol 68 (6):364–69. doi:10.1007/s002040050083.
   PubMed Web of Science ®Google Scholar
• Marquardt, J. U., L. Gomez-Quiroz, L. O. Arreguin Camacho, F. Pinna, Y. H. Lee, M. Kitade, M. P. Domínguez, D. Castven, K. Breuhahn, E. A. Conner, et al. 2015. Curcumin effectively inhibits oncogenic NF-kB signaling and restrains stemness features in liver cancer. J. Hepatol 63 (3):661–69. doi:10.1016/j.jhep.2015.04.018.
   PubMed Web of Science ®Google Scholar
• Mary, C. P. V., S. Vijayakumar, and R. Shankar. 2018. Metal chelating ability and antioxidant properties of curcumin-metal complexes–A DFT approach. J. Mol. Graph. Model 79:1–14. doi:10.1016/j.jmgm.2017.10.022.
   PubMed Web of Science ®Google Scholar
• Masuda, T., T. Maekawa, K. Hidaka, H. Bando, Y. Takeda, and H. Yamaguchi. 2001. Chemical studies on antioxidant mechanism of curcumin: Analysis of oxidative coupling products from curcumin and linoleate. J. Agric. Food Chem 49 (5):2539–47. doi:10.1021/jf001442x.
   PubMed Web of Science ®Google Scholar
• McKenna, I. M., M. P. Waalkes, L. C. Chen, and T. Gordon. 1997. Comparison of inflammatory lung responses in Wistar rats and C57 and DBA mice following acute exposure to cadmium oxide fumes. Toxicol. Appl. Pharmacol 146 (2):196–206. doi:10.1006/taap.1997.8241.
   PubMed Web of Science ®Google Scholar
• Mehta, A., S. C. Pant, and S. J. S. Flora. 2006. Monoisoamyl dimercaptosuccinic acid induced changes in pregnant female rats during late gestation and lactation. Reprod. Toxicol 21 (1):94–103. doi:10.1016/j.reprotox.2005.05.008.
   PubMed Web of Science ®Google Scholar
• Meja, K. K., S. Rajendrasozhan, D. Adenuga, S. K. Biswas, I. K. Sundar, G. Spooner, J. A. Marwick, P. Chakravarty, D. Fletcher, P. Whittaker, et al. 2008. Curcumin restores corticosteroid function in monocytes exposed to oxidants by maintaining HDAC2. Am. J. Respir. Cell Mol. Biol 39 (3):312–23. doi:10.1165/rcmb.2008-0012OC.
   PubMed Web of Science ®Google Scholar
• Meng, Z., C. Yan, Q. Deng, D. F. Gao, and X. L. Niu. 2013. Curcumin inhibits LPS-induced inflammation in rat vascular smooth muscle cells in vitro via ROS-relative TLR4-MAPK/NF-κB pathways. Acta Pharmacol. Sin 34 (7):901–11. doi:10.1038/aps.2013.24.
   PubMed Web of Science ®Google Scholar
• Menon, V. P., and A. R. Sudheer. 2007. Antioxidant and anti-inflammatory properties of curcumin. Adv. Exp. Med. Biol 595:105–25. doi:10.1007/978-0-387-46401-5_3.
   PubMed Web of Science ®Google Scholar
• Mohajeri, M., M. Rezaee, and A. Sahebkar. 2017. Cadmium-induced toxicity is rescued by curcumin: A review. Biofactors 43:645–61. doi:10.1002/biof.1376.
   PubMed Web of Science ®Google Scholar
• Monteiro, C., J. M. P. Ferreira de Oliveira, F. Pinho, V. Bastos, H. Oliveira, F. Peixotoand, and C. Santos. 2018. Biochemical and translational analyses of cadmium–induced mitochondrial dysfunction and oxidative stress in human osteoblasts. J. Toxicol. Environ. Health A 81 (15):705–17. doi:10.1080/15287394.2018.1485122.
   PubMed Web of Science ®Google Scholar
• Morse, D., and A. M. Choi. 2002. Heme oxygenase-1: The “emerging molecule” has arrived. Am. J. Respir. Cell Mol. Biol 27 (1):8–16. doi:10.1165/ajrcmb.27.1.4862.
   PubMed Web of Science ®Google Scholar
• Motaghinejad, M., M. Motevalian, S. Fatima, F. Faraji, and S. Mozaffari. 2017. The neuroprotective effect of curcumin against nicotine-induced neurotoxicity is mediated by CREB-BDNF signaling pathway. Neurochem. Res 42 (10):2921–32. doi:10.1007/s11064-017-2323-8.
   PubMed Web of Science ®Google Scholar
• Motterlini, R., R. Foresti, R. Bassi, and C. J. Green. 2000. Curcumin, an antioxidant and anti-inflammatory agent, induced heme oxygenase-1 and protects endothelial cells against oxidative stress. Free Radic. Biol. Med 28 (8):1303–12. doi:10.1016/S0891-5849(00)00294-X.
   PubMed Web of Science ®Google Scholar
• Nair, A., A. Amalraj, J. Jacob, A. B. Kunnumakkara, and S. Gopi. 2019. Non-curcuminoids from turmeric and their potential in cancer therapy and anticancer drug delivery formulations. Biomolecules 9 (1):13. doi:10.3390/biom9010013.
   PubMed Web of Science ®Google Scholar
• Nazari, Q. A., T. Kume, N. Izuo, Y. Takada-Takatori, A. Imaizumi, T. Hashimoto, Y. Izumi, and A. Akaike. 2013. Neuroprotective effects of curcumin and highly bioavailable curcumin on oxidative stress induced by sodium nitroprusside in rat striatal cell culture. Biol. Pharm. Bull 36 (8):1356–62. doi:10.1248/bpb.b13-00300.
   PubMed Web of Science ®Google Scholar
• Nimse, S. B., and D. Pal. 2015. Free radicals, natural antioxidants, and their reaction mechanisms. RSC Adv 5 (35):27986–8006. doi:10.1039/C4RA13315C.
   Web of Science ®Google Scholar
• Oberdörster, G. 1992. Pulmonary deposition, clearance and effects of inhaled soluble and insoluble cadmium compounds. IARC Sci. Publ 118:189–204.
   PubMedGoogle Scholar
• Ogawa, T., E. Kobayashi, Y. Okubo, Y. Suwazono, T. Kido, and K. Nogawa. 2004. Relationship among prevalence of patients with Itai-itai disease, prevalence of abnormal urinary findings, and cadmium concentrations in rice of individual hamlets in the Jinzu River basin, Toyama prefecture of Japan. Int. J. Environ. Health. Res 14 (4):243–52. doi:10.1080/09603120410001725586.
   PubMed Web of Science ®Google Scholar
• Oguzturk, H., O. Ciftci, M. Aydin, N. Timurkaan, A. Beytur, and F. Yilmaz. 2012. Ameliorative effects of curcumin against acute cadmium toxicity on male reproductive system in rats. Andrologia 44 (4):243–49. doi:10.1111/j.1439-0272.2012.01273.x.
   PubMed Web of Science ®Google Scholar
• Patra, R., A. K. Rautray, and D. Swarup. 2011. Oxidative stress in lead and cadmium toxicity and its amelioration. Vet. Med. Int 2011:457327. doi:10.4061/2011/457327.
   PubMedGoogle Scholar
• Philip, M., D. A. Rowley, and H. Schreiber. 2004. Inflammation as a tumor promoter in cancer induction. Semin. Cancer Biol 14 (6):433–39. doi:10.1016/j.semcancer.2004.06.006.
   PubMed Web of Science ®Google Scholar
• Prasad, S., and B. B. Aggarwal. 2011. Turmeric, the golden spice: From traditional medicine to modern medicine. In Herbal Medicine: Biomolecular and Clinical Aspects (pp. 263-88), ed. I. F. F. Benzie, and S. Wachtel-Galor. Boca Raton (FL): CRC Press/Taylor & Francis.
   Google Scholar
• Priyadarsini, K. I. 2013. Chemical and structural features influencing the biological activity of curcumin. Curr. Pharm. Des 19:2093–100. doi:10.2174/138161213805289228.
   PubMed Web of Science ®Google Scholar
• Rafati Rahimzadeh, M., M. Rafati Rahimzadeh, S. Kazemi, and A. A. Moghadamnia. 2017. Cadmium toxicity and treatment: An update. Caspian J. Intern. Med 8:135–45. doi:10.22088/cjim.8.3.135.
   PubMed Web of Science ®Google Scholar
• Rahmani, A. H., M. A. Alsahli, S. M. Aly, M. A. Khan, and Y. H. Aldebasi. 2018. Role of curcumin in disease prevention and treatment. Adv. Biomed. Res 7 (1):38. doi:10.4103/abr.abr_147_16.
   PubMedGoogle Scholar
• Ramirez-Tortosa, M. C., M. D. Mesa, M. C. Aguilera, J. L. Quiles, L. Baró, C. L. Ramirez-Tortosa, E. Martinez-Victoria, and A. Gil. 1999. Oral administration of a turmeric extract inhibits LDL oxidation and has hypocholesterolemic effects in rabbits with experimental atherosclerosis. Atherosclerosis 147:371–78. doi:10.1016/s0021-9150(99)00207-5.
   PubMed Web of Science ®Google Scholar
• Rana, S. V. 2008. Metals and apoptosis: Recent developments. J. Trace Elem. Med. Biol 22 (4):262–84. doi:10.1016/j.jtemb.2008.08.002.
   PubMed Web of Science ®Google Scholar
• Reddy, A. C., and B. R. Lokesh. 1994. Effect of dietary turmeric (Curcuma longa) on iron-induced lipid peroxidation in the rat liver. Food Chem. Toxicol 32 (3):279–83. doi:10.1016/0278-6915(94)90201-1.
   PubMed Web of Science ®Google Scholar
• Rikans, L. E., and T. Yamano. 2000. Mechanisms of cadmium-mediated acute hepatotoxicity. J. Biochem. Mol. Toxicol 14:110–17. doi:10.1002/(sici)1099-0461(2000)14:2<10::aid-jbt7>3.0.co;2-j.
   PubMed Web of Science ®Google Scholar
• Rodríguez-López, E., M. Tamayo-Ortiz, A. C. Ariza, E. Ortiz-Panozo, A. L. Deierlein, I. Pantic, M. C. Tolentino, G. Estrada-Gutiérrez, S. Parra-Hernández, A. Espejel-Núñez, et al. 2020. Early-life dietary cadmium exposure and kidney function in 9-year-old children from the PROGRESS cohort. Toxics 8 (4):83. doi:10.3390/toxics8040083.
   Web of Science ®Google Scholar
• Rosen, E. M., M. I. Muñoz, T. McElrath, D. E. Cantonwine, and K. K. Ferguson. 2018. Environmental contaminants and preeclampsia: A systematic literature review. J. Toxicol. Environ. Health B 21:291–319. doi:10.1080/10937404.2018.1554515.
   PubMed Web of Science ®Google Scholar
• Sa, G., and T. Das. 2008. Anti cancer effects of curcumin: Cycle of life and death. Cell Div 3:14. doi:10.1186/1747-1028-3-14.
   PubMed Web of Science ®Google Scholar
• Salama, A. F., and S. M. El-Bahr. 2007. Effect of curcumin on cadmium-induced oxidative testicular damage in rats. J. Med. Res. Inst 28:167–73.
   Google Scholar
• Sandur, S. K., M. K. Pandey, B. Sung, K. S. Ahn, A. Murakami, G. Sethi, P. Limtrakul, V. Badmaev, and B. B. Aggarwal. 2007. Curcumin, demethoxycurcumin, bisdemethoxycurcumin, tetrahydrocurcumin and turmerones differentially regulate anti-inflammatory and anti-proliferative responses through a ROS-independent mechanism. Carcinogenesis 28 (8):1765–73. doi:10.1093/carcin/bgm123.
   PubMed Web of Science ®Google Scholar
• Sangartit, W., U. Kukongviriyapan, W. Donpunha, P. Pakdeechote, V. Kukongviriyapan, P. Surawattanawan, and S. E. Greenwald. 2014. Tetrahydrocurcumin protects against cadmium-induced hypertension, raised arterial stiffness and vascular remodeling in mice. PLoS One 9:e114908. doi:10.1371/journal.pone.0114908.
   PubMed Web of Science ®Google Scholar
• Sarkar, S., P. Yadav, R. Trivedi, A. K. Bansal, and D. Bhatnagar. 1995. Cadmium-induced lipid peroxidation and the status of the antioxidant system in rat tissues. J. Trace Elem. Med. Biol 9 (3):144–49. doi:10.1016/S0946-672X(11)80038-6.
   PubMed Web of Science ®Google Scholar
• Satarug, S. 2018. Dietary cadmium intake and its effects on kidneys. Toxics 6 (1):15. doi:10.3390/toxics6010015.
   PubMed Web of Science ®Google Scholar
• Satarug, S., D. A. Vesey, and G. C. Gobe. 2017. Kidney cadmium toxicity, diabetes and high blood pressure: The perfect storm. Tohoku J. Exp. Med 241 (1):65–87. doi:10.1620/tjem.241.65.
   PubMed Web of Science ®Google Scholar
• Satarug, S., S. H. Garrett, M. A. Sens, and D. A. Sens. 2010. Cadmium, environmental exposure, and health outcomes. Environ. Health Perspect 118 (2):182–90. doi:10.1289/ehp.0901234.
   PubMed Web of Science ®Google Scholar
• Sauer, J. M., M. P. Waalkes, S. B. Hooser, R. K. Kuester, C. A. Mcqueen, and I. G. Sipes. 1997. Suppression of Kupffer cell function prevents cadmium induced hepatocellular necrosis in the male Sprague-Dawley rat. Toxicology 121 (2):155–64. doi:10.1016/s0300-483x(97)00062-0.
   PubMed Web of Science ®Google Scholar
• Schnaper, H. W. 2014. Remnant nephron physiology and the progression of chronic kidney disease. Pediatr. Nephrol 29 (2):193–202. doi:10.1007/s00467-013-2494-8.
   PubMed Web of Science ®Google Scholar
• Sehgal, A., M. Kumar, M. Jain, and D. K. Dhawan. 2011. Combined effects of curcumin and piperine in ameliorating benzo(a)pyrene induced DNA damage. Food Chem. Toxicol 49 (11):3002–06. doi:10.1016/j.fct.2011.07.058.
   PubMed Web of Science ®Google Scholar
• Sen Gupta, R., J. Kim, C. Gomes, S. Oh, J. Park, W. B. Im, J. Y. Seong, R. S. Ahn, H. B. Kwon, and J. Soh. 2004. Effect of ascorbic acid supplementation on testicular steroidogenesis and germ cell death in cadmium-treated male rats. Mol. Cell. Endocrinol 221 (1–2):57–66. doi:10.1016/j.mce.2004.03.012.
   PubMed Web of Science ®Google Scholar
• Shaikh, Z. A., T. T. Vu, and K. Zaman. 1999. Oxidative stress as a mechanism of chronic cadmium-induced hepatotoxicity and renal toxicity and protection by antioxidants. Toxicol. Appl. Pharmacol 154 (3):256–63. doi:10.1006/taap.1998.8586.
   PubMed Web of Science ®Google Scholar
• Shakibaei, M., T. John, G. Schulze-Tanzil, I. Lehmann, and A. Mobasheri. 2007. Suppression of NF-κB activation by curcumin leads to inhibition of expression of cyclo-oxygenase-2 and matrix metalloproteinase-9 in human articular chondrocytes: Implications for the treatment of osteoarthritis. Biochem. Pharmacol 73 (9):1434–45. doi:10.1016/j.bcp.2007.01.005.
   PubMed Web of Science ®Google Scholar
• Sharma, R. A., C. R. Ireson, R. D. Verschoyle, K. A. Hill, M. L. Williams, C. Leuratti, M. M. Manson, L. J. Marnett, W. P. Steward, and A. Gescher. 2001. Effects of dietary curcumin on glutathione S-transferase and malondialdehyde-DNA adducts in rat liver and colon mucosa: Relationship with drug levels. Clin. Cancer Res 7:1452–58.
   PubMed Web of Science ®Google Scholar
• Sharma, S., and A. Kumari. 2016. Amelioration of curcumin against cadmium induced oxidative stress in lung of albino mice. Int. J. Adv. Res 4 (5):1020–26. doi:10.21474/IJAR01/455.
   Google Scholar
• Sharma, S., and A. Kumari. 2018. Protective effect of Curcuma longa administration on lung of mice exposed to cadmium. Asian J. Pharm. Clin. Res 11 (10):536–39. doi:10.22159/ajpcr.2018.v11i10.29010.
   Google Scholar
• Shehzad, A., and Y. S. Lee. 2013. Molecular mechanisms of curcumin action: Signal transduction. Biofactors 39 (1):27–36. doi:10.1002/biof.1065.
   PubMed Web of Science ®Google Scholar
• Shi, L.-Y., L. Zhang, H. Li, T.-L. Liu, J.-C. Lai, Z.-B. Wu, and J. Qin. 2018. Protective effects of curcumin on acrolein-induced neurotoxicity in HT22 mouse hippocampal cells. Pharmacological Reports 70 (5):1040–46. doi:10.1016/j.pharep.2018.05.006.
   Web of Science ®Google Scholar
• Shoba, G., D. Joy, T. Joseph, M. Majeed, R. Rajendran, and P. S. Srinivas. 1998. Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta. Med 64 (04):353–56. doi:10.1055/s-2006-957450.
   PubMed Web of Science ®Google Scholar
• Silva, J. N., N. B. N. Moncao, R. R. S. de Freitas, A. M. G. L. Cito, M. H. Chaves, M. R. S. de Araujo, D. J. B. Lima, C. Pessoa, A. de Lima, E. C. C. Araujo, et al. 2020. Toxicological, chemopreventive and cytotoxic potentialities of rare vegetal species and supporting findings for the Brazilian Unified Health System (SUS). J. Toxicol. Environ. Health A. 83(13–14):525–45. doi:10.1080/15287394.2020.1780658
   PubMed Web of Science ®Google Scholar
• Sreejayan,, and M. N. A. Rao. 1994. Curcuminoids as potent inhibitors of lipid peroxidation. J. Pharm. Pharmacol 46:1013–16. doi:10.1111/j.2042-7158.1994.tb03258.x.
   PubMed Web of Science ®Google Scholar
• Srimal, R. C., and B. N. Dhawan. 1973. Pharmacology of diferuloyl methane (curcumin), a non-steroidal anti-inflammatory agent. J. Pharm. Pharmacol 25 (6):447–52. doi:10.1111/j.2042-7158.1973.tb09131.x.
   PubMed Web of Science ®Google Scholar
• Srivastava, P., Y. K. Dhuriya, V. Kumar, A. Srivastava, R. Gupta, R. K. Shukla, R. S. Yadav, H. N. Dwivedi, A. B. Pant, and V. K. Khanna. 2018. PI3K/Akt/GSK3β induced CREB activation ameliorates arsenic mediated alterations in NMDA receptors and associated signaling in rat hippocampus: Neuroprotective role of curcumin. Neurotoxicology 67:190–205. doi:10.1016/j.neuro.2018.04.018.
   PubMed Web of Science ®Google Scholar
• Stohs, S. J., D. Bagchi, E. Hassoun, and M. Bagchi. 2000. Oxidative mechanisms in the toxicity of chromium and cadmium ions. J. Environ. Pathol. Toxicol. Oncol 19:201–13. doi:10.1615/JEnvironPatholToxicolOncol.v20.i2.10.
   PubMedGoogle Scholar
• Strasser, E. M., B. Wessner, N. Manhart, and E. Roth. 2005. The relationship between the anti-inflammatory effects of curcumin and cellular glutathione content in myelomonocytic cells. Biochem. Pharmacol 70 (4):552–59. doi:10.1016/j.bcp.2005.05.030.
   PubMed Web of Science ®Google Scholar
• Su, J. B. 2015. Vascular endothelial dysfunction and pharmacological treatment. World. J. Cardiol 7 (11):719–41. doi:10.4330/wjc.v7.i11.719.
   PubMed Web of Science ®Google Scholar
• Tapia, E., Z. L. Zatarain-Barrón, R. Hernández-Pando, G. Zarco-Márquez, E. Molina-Jijón, M. Cristóbal-García, J. Santamaría, and J. Pedraza-Chaverri. 2013. Curcumin reverses glomerular hemodynamic alterations and oxidant stress in 5/6 nephrectomized rats. Phytomedicine 20 (3–4):359–66. doi:10.1016/j.phymed.2012.11.014.
   PubMed Web of Science ®Google Scholar
• Tarasub, N., C. Tarasub, and W. D. N. Ayutthaya. 2011. Protective role of curcumin on cadmium-induced nephrotoxicity in rats. J. Environ. Chem. Ecotoxicol 3:17–24.
   Google Scholar
• Tarasub, N., K. Narula, and W. D. N. Ayutthaya. 2008. Effects of curcumin on cadmium-induced hepatotoxicity in rats. Thai J. Toxicol 23:100–07.
   Google Scholar
• Tarasub, N., T. Junseecha, C. Tarasub, and W. D. N. Ayutthaya. 2012. Protective effects of curcumin, vitamin C, or their combination on cadmium-induced hepatotoxicity. J. Basic Clin. Pharm 3 (2):273–81. doi:10.4103/0976-0105.103821.
   PubMedGoogle Scholar
• Taylor, M., S. Moore, S. Mourtas, A. Niarakis, F. Re, C. Zona, B. La Ferla, F. Nicotra, M. Masserini, S. G. Antimisiaris, et al. 2011. Effect of curcumin-associated and lipid ligand-functionalized nanoliposomes on aggregation of the Alzheimer’s Aβ peptide. Nanomedicine 7 (5):541–50. doi:10.1016/j.nano.2011.06.015.
   PubMed Web of Science ®Google Scholar
• Thévenod, F. 2003. Nephrotoxicity and the proximal tubule. Insights from cadmium. Nephron. Physiol 93 (4):87–93. doi:10.1159/000070241.
   Google Scholar
• Tomeh, M. A., R. Hadianamrei, and X. Zhao. 2019. A review of curcumin and its derivatives as anticancer agents. Int. J. Mol. Sci 20 (5):1033. doi:10.3390/ijms20051033.
   PubMed Web of Science ®Google Scholar
• Ukil, A., S. Maity, S. Karmakar, N. Datta, J. R. Vedasiromoni, and P. K. Das. 2003. Curcumin, the major component of food flavour turmeric, reduces mucosal injury in trinitrobenzene sulphonic acid-induced colitis. Br. J. Pharmacol 139 (2):209–18. doi:10.1038/sj.bjp.0705241.
   PubMed Web of Science ®Google Scholar
• Vadhan-Raj, S., D. Weber, M. Wang, S. Giralt, S. Thomas, R. Alexanian, X. Zhou, P. Patel, C. Bueso-Ramos, R. Newman, et al. 2007. Curcumin downregulates NF-kB and related genes in patients with multiple myeloma: Results of a phase I/II study. Blood 110 (11):1177. doi:10.1182/blood.V110.11.1177.1177.
   Google Scholar
• Vaidya, V. S., M. A. Ferguson, and J. V. Bonventre. 2008. Biomarkers of acute kidney injury. Annu. Rev. Pharmacol. Toxicol 48 (1):463–93. doi:10.1146/annurev.pharmtox.48.113006.094615.
   PubMedGoogle Scholar
• Velayudhan, K. C., N. Dikshit, and M. A. Nizar. 2012. Ethnobotany of turmeric (Curcuma longa L). Indian J. Tradit. Know 11:607–14.
   Web of Science ®Google Scholar
• Venkatesan, N., and G. Chandrakasan. 1995. Modulation of cyclophosphamide-induced early lung injury by curcumin, an anti-inflammatory antioxidant. Mol. Cell. Biochem 142:79–87. doi:10.1007/BF00928916.
   PubMed Web of Science ®Google Scholar
• Waalkes, M. P. 2000. Cadmium carcinogenesis in review. J. Inorg. Biochem 79 (1–4):241–44. doi:10.1016/s0162-0134(00)00009-x.
   PubMed Web of Science ®Google Scholar
• Waisberg, M., P. Joseph, B. Hale, and D. Beyersmann. 2003. Molecular and cellular mechanisms of cadmium carcinogenesis. Toxicology 192 (2–3):95–117. doi:10.1016/s0300-483x(03)00305-6.
   PubMed Web of Science ®Google Scholar
• Wang, B., and Y. Du. 2013. Cadmium and its neurotoxic effects. Oxid. Med. Cell. Longev 2013:898034. doi:10.1155/2013/898034.
   PubMed Web of Science ®Google Scholar
• Wang, J., J. Ma, J. H. Gu, F. Y. Wang, X. S. Shang, H. R. Tao, and X. Wang. 2017. Regulation of type II collagen, matrix metalloproteinase-13 and cell proliferation by interleukin-1β is mediated by curcumin via inhibition of NF-κB signaling in rat chondrocytes. Mol. Med. Rep 16 (2):1837–45. doi:10.3892/mmr.2017.6771.
   PubMed Web of Science ®Google Scholar
• Wang, J. B., L. L. Qi, S. D. Zheng, H. Z. Wang, and T. X. Wu. 2009. Curcumin suppresses PPARδ expression and related genes in HT-29 cells. World J. Gastroenterol 15:1346–52. doi:10.3748/wjg.15.1346.
   PubMed Web of Science ®Google Scholar
• Wang, R. Y., H. Li, Y. Xu, Y. B. Li, H. L. Wu, H. Guo, J. Z. Zhang, J. J. Zhang, X. Y. Pan, and X. J. Li. 2010. Curcumin produces neuroprotective effects via activating brain-derived neurotrophic factor/TrkB-dependent MAPK and PI-3K cascades in rodent cortical neurons. Prog. Neuropsychopharmacol. Biol. Psychiat 34:147–53. doi:10.1016/j.pnpbp.2009.10.016.
   PubMed Web of Science ®Google Scholar
• Wang, W., Y. Sun, J. Liu, J. Wang, Y. LI, H. Li, W. Zhang, and H. Liao. 2012b. Protective effect of theaflavins on cadmium-induced testicular toxicity in male rats. Food Chem. Toxicol. 50 (9):3243–50. doi:10.1016/j.fct.2012.06.031.
   PubMed Web of Science ®Google Scholar
• Wang, W. H., I. T. Chiang, K. Ding, J. G. Chung, W. J. Lin, S. S. Lin, and J. J. Hwang. 2012a. Curcumin-induced apoptosis in human hepatocellular carcinoma J5 cells: Critical role of Ca+2-dependent pathway. Evid. Based Complement. Alternat. Med 2012:512907. doi:10.1155/2012/512907.
   PubMed Web of Science ®Google Scholar
• Wang, X. P., H. M. Chan, R. A. Goyer, and M. G. Cherian. 1993. Nephrotoxicity of repeated injections of cadmium-metallothionein in rats. Toxicol. Appl. Pharmacol 119 (1):11–16. doi:10.1006/taap.1993.1038.
   PubMed Web of Science ®Google Scholar
• Wigle, D. T., T. E. Arbuckle, M. C. Turner, A. Bérubé, Q. Yang, S. Liu, and D. Krewski. 2008. Epidemiologic evidence of relationships between reproductive and child health outcomes and environmental chemical contaminants. J. Toxicol. Environ. Health B 11:373–517. doi:10.1080/10937400801921320.
   PubMed Web of Science ®Google Scholar
• Wilken, R., M. S. Veena, M. B. Wang, and E. S. Srivatsan. 2011. Curcumin: A review of anti-cancer properties and therapeutic activity in head and neck squamous cell carcinoma. Mol. Cancer 10 (1):12. doi:10.1186/1476-4598-10-12.
   PubMed Web of Science ®Google Scholar
• Wu, J., Q. Li, X. Wang, S. Yu, L. Li, X. Wu, Y. Chen, J. Zhao, and Y. Zhao. 2013. Neuroprotection by curcumin in ischemic brain injury involves the Akt/Nrf2 pathway. PLoS One 8:e59843. doi:10.1371/journal.pone.0059843.
   PubMed Web of Science ®Google Scholar
• Xu, S., H. Pi, Y. Chen, N. Zhang, P. Guo, Y. Lu, M. He, J. Xie, M. Zhong, Y. Zhang, et al. 2013. Cadmium induced Drp1-dependent mitochondrial fragmentation by disturbing calcium homeostasis in its hepatotoxicity. Cell Death Dis 4:e540. doi:10.1038/cddis.2013.7.
   PubMed Web of Science ®Google Scholar
• Yang, H., and Y. Shu. 2015. Cadmium Transporters in the Kidney and Cadmium-Induced Nephrotoxicity. Int. J. Mol. Sci. 16 (1):1484–94. doi:10.3390/ijms16011484.
   PubMed Web of Science ®Google Scholar
• Yesiloglu, Y., and H. Aydin. 2013. Evaluation of antioxidant activities of turmeric extracts from Turkey. Asian J. Chem. 25 (13):7199–8204. doi:10.14233/ajchem.2013.14503.
   Google Scholar
• Yuan, J., W. Liu, H. Zhu, X. Zhang, Y. Feng, Y. Chen, H. Feng, and J. Lin. 2017. Curcumin attenuates blood-brain barrier disruption after subarachnoid hemorrhage in mice. J. Surg. Res. 207:85–91. doi:10.1016/j.jss.2016.08.090.
   PubMed Web of Science ®Google Scholar
• Zalups, R. K. 1997. Influence of different degrees of reduced renal mass on the renal and hepatic disposition of administered cadmium. J. Toxicol. Environ. Health 51 (3):245–64. doi:10.1080/00984109708984025.
   PubMed Web of Science ®Google Scholar
• Zalups, R. K., and S. Ahmad. 2003. Molecular handling of cadmium in transporting epithelia. Toxicol. Appl. Pharmacol 186 (3):163–88. doi:10.1016/s0041-008x(02)00021-2.
   PubMed Web of Science ®Google Scholar
• Zanotto-Filho, A., E. Braganhol, M. I. Edelweiss, G. A. Behr, R. Zanin, R. Schröder, A. Simões-Pires, A. M. Battastini, and J. C. Moreira. 2012. The curry spice curcumin selectively inhibits cancer cells growth in vitro and in preclinical model of glioblastoma. J. Nutr. Biochem 23 (6):591–601. doi:10.1016/j.jnutbio.2011.02.015.
   PubMed Web of Science ®Google Scholar
• Zhu, Y., and S. Bu. 2017. Curcumin induces autophagy, apoptosis, and cell cycle arrest in human pancreatic cancer cells. Evid. Based Complement. Alternat. Med 2017:5787218. doi:10.1155/2017/5787218.
   PubMed Web of Science ®Google Scholar
• Zikaki, K., I. K. Aggeli, C. Gaitanaki, and I. Beis. 2014. Curcumin induces the apoptotic intrinsic pathway via upregulation of reactive oxygen species and JNKs in H9c2 cardiac myoblasts. Apoptosis 19 (6):958–74. doi:10.1007/s10495-014-0979-y.
   PubMed Web of Science ®Google Scholar
• Zoheb, S. M., A. Prakash, A. Rahal, R. Mandil, N. K. Gangwar, and S. K. Garg. 2014. Curcumin attenuates oxidative stress-induced altered histoarchitecture of testes in experimentally exposed rats to metal mixture (lead, arsenic, cadmium, mercury, iron, and copper) for 28 days. Toxicological & Environmental Chemistry 96 (4):660–79. doi:10.1080/02772248.2014.975425.
   Web of Science ®Google Scholar
• Zwolak, I. 2020. The role of selenium in arsenic and cadmium toxicity: An updated review of scientific literature. Biol. Trace Elem. Res 193:44–63. doi:10.1007/s12011-019-01691-w.
   PubMed Web of Science ®Google Scholar