Experimental models of chemically induced Parkinson’s disease in zebrafish at the embryonic larval stage: a systematic review

References

• Abrão, L. C., D. G. Costa-Silva, M. G. dos Santos, M. B. R. Cerqueira, E. Badiale-Furlong, A. L. Muccillo-Baisch, and M. A. Hort. 2022. Toxicity evaluation of traditional and organic yerba mate (Ilex paraguariensis A. St.-Hil.) extracts. J. Toxicol. Environ. Health A 85 (11):461–79. doi:10.1080/15287394.2022.2035873.
   PubMed Web of Science ®Google Scholar
• Acharya, S., B. M. Safaie, P. Wongkongkathep, M. I. Ivanova, A. Attar, F. Klärner, T. Schrader, J. A. Loo, G. Bitan, and L. J. Lapidus. 2014. Molecular basis for preventing α-synuclein aggregation by a molecular tweezer. J. Biol. Chem. 289 (15):10727–37. doi:10.1074/jbc.M113.524520.
   PubMed Web of Science ®Google Scholar
• Amaraneni, M., J. Pang, T. B. Mortuza, S. Muralidhara, B. S. Cummings, C. A. White, C. V. Vorhees, J. Zastre, and J. V. Bruckner. 2017. Brain uptake of deltamethrin in rats as a function of plasma protein binding and blood–brain barrier maturation. NeuroToxicology 62:24–29. doi:10.1016/j.neuro.2017.04.009.
   PubMed Web of Science ®Google Scholar
• Arslan-Ergul, A., E. Begun, E. T. Karoglu, D. O. Halim, and M. M. Adams. 2016. Short-term dietary restriction in old zebrafish changes cell senescence mechanisms. Neuroscience 334:64–75. doi:10.1016/j.neuroscience.2016.07.033.
   PubMed Web of Science ®Google Scholar
• Bailey, J., A. Oliveri, and E. D. Levin. 2013. Zebrafish model systems for developmental neurobehavioral toxicology. Birth Defects Res. (Part C) 99 (1):14–23. doi:10.1002/bdrc.21027.
   PubMedGoogle Scholar
• Bakthavatsalam, S., S. Das Sharma, M. Sonawane, V. Thirumalai, and A. Datta. 2014. A zebrafish model of manganism reveals reversible and treatable symptoms that are independent of neurotoxicity. Dis. Model Mech. 7:1239–51. doi:10.1242/dmm.016683.
   PubMed Web of Science ®Google Scholar
• Barker, R. A., and A. Björklund. 2020. Animal models of Parkinson’s disease: Are they useful or not? J. Parkinsons Dis 10 (4):1335–42. doi:10.3233/JPD-202200.
   PubMedGoogle Scholar
• Barlow, B. K., D. A. Cory-Slechta, E. K. Richfield, and M. Thiruchelvam. 2007. The gestational environment and Parkinson’s disease: Evidence for neurodevelopmental origins of a neurodegenerative disorder. Reprod. Toxicol 23 (3):457–70. doi:10.1016/j.reprotox.2007.01.007.
   PubMed Web of Science ®Google Scholar
• Barlow, B. K., D. W. Lee, D. A. Cory-Slechta, and L. A. Opanashuk. 2005. Modulation of antioxidant defense systems by the environmental pesticide maneb in dopaminergic cells. NeuroToxicology 26 (1):63–75. doi:10.1016/j.neuro.2004.07.004.
   PubMed Web of Science ®Google Scholar
• Bashirzade, A. A., K. N. Zabegalov, A. D. Volgin, A. S. Belova, K. A. Demin, M. S. de Abreu, V. Y. Babchenko, K. A. Bashirzade, K. B. Yenkoyan, M. A. Tikhonova, et al. 2022. Modeling neurodegenerative disorders in zebrafish. Neurosci. Biobehav. Rev 138:104679. doi:10.1016/j.neubiorev.2022.104679.
   PubMed Web of Science ®Google Scholar
• Basnet, R. M., D. Zizioli, S. Taweedet, D. Finazzi, and M. Memo. 2019. Zebrafish larvae as a behavioral model in neuropharmacology. Biomedicines 7 (1):23. doi:10.3390/biomedicines7010023.
   PubMed Web of Science ®Google Scholar
• Bauer, B., A. Mally, and D. Liedtke. 2021. Zebrafish embryos and larvae as alternative animal models for toxicity testing. Int. J. Mol. Sci 22 (24):13417. doi:10.3390/ijms222413417.
   PubMed Web of Science ®Google Scholar
• Benvenutti, R., M. Marcon, C. G. Reis, L. R. Nery, C. Miguel, A. P. Herrmann, M. R. M. Vianna, and A. Piato. 2018. N-acetylcysteine protects against motor, optomotor and morphological deficits induced by 6-OHDA in zebrafish larvae. PeerJ 6:1–17. doi:10.7717/peerj.4957.
   Web of Science ®Google Scholar
• Betarbet, R., T. B. Sherer, and J. T. Greenamyre. 2002. Animal models of Parkinson’s disease. BioEssays 24 (4):308–18. doi:10.1002/bies.10067.
   PubMed Web of Science ®Google Scholar
• Blanch, A., F. Balada, and A. Aluja. 2014. Habituation in acoustic startle reflex: Individual differences in personality. Int. J. Psychophysiol 91 (3):232–39. doi:10.1016/j.ijpsycho.2014.01.001.
   PubMed Web of Science ®Google Scholar
• Blandini, F., and M. T. Armentero. 2012. Animal models of Parkinson’s disease. FEBS J. 279 (7):1156–66. doi:10.1111/j.1742-4658.2012.08491.x.
   PubMed Web of Science ®Google Scholar
• Bowman, A. B., G. F. Kwakye, E. Herrero Hernández, and M. Aschner. 2011. Role of manganese in neurodegenerative diseases. J. Trace Elem. Med. Biol 25 (4):191–203. doi:10.1016/j.jtemb.2011.08.144.
   PubMed Web of Science ®Google Scholar
• Bretaud, S., S. Lee, and S. Guo. 2004. Sensitivity of zebrafish to environmental toxins implicated in Parkinson’s disease. Neurotoxicol. Teratol. 26 (6):857–64. doi:10.1016/j.ntt.2004.06.014.
   PubMed Web of Science ®Google Scholar
• Brooks, A. I., C. A. Chadwick, H. A. Gelbard, D. A. Cory-Slechta, and H. J. Federoff. 1999. Paraquat elicited neurobehavioral syndrome caused by dopaminergic neuron loss. Brain Res. 823 (1–2):1–10. doi:10.1016/S0006-8993(98)01192-5.
   PubMed Web of Science ®Google Scholar
• Cao, F., C. L. Souders 2nd, P. Li, S. Pang, X. Liang, L. Qiu, and C. J. Martyniuk. 2019. Developmental neurotoxicity of maneb: Notochord defects, mitochondrial dysfunction and hypoactivity in zebrafish (Danio rerio) embryos and larvae. Ecotoxicol. Environ. Saf. 170:227–37. doi:10.1016/j.ecoenv.2018.11.110.
   PubMed Web of Science ®Google Scholar
• Cao, Z., M. Su, H. Wang, L. Zhou, Z. Meng, G. Xiong, X. Liao, and H. Lu. 2021. Carboxyl graphene oxide nanoparticles induce neurodevelopmental defects and locomotor disorders in zebrafish larvae. Chemosphere 270:128611. doi:10.1016/j.chemosphere.2020.128611.
   PubMed Web of Science ®Google Scholar
• Cassar, S., I. Adatto, J. L. Freeman, J. T. Gamse, I. Iturria, C. Lawrence, A. Muriana, R. T. Peterson, S. Van Cruchten, and L. I. Zon. 2020. Use of zebrafish in drug discovery toxicology. Chem. Res. Toxicol. 33 (1):95–118. doi:10.1021/acs.chemrestox.9b0033.
   PubMed Web of Science ®Google Scholar
• Castello, P. R., D. A. Drechsel, and M. Patel. 2007. Mitochondria are a major source of paraquat-induced reactive oxygen species production in the brain. J. Biol. Chem. 282 (19):14186–93. doi:10.1074/jbc.M700827200.
   PubMed Web of Science ®Google Scholar
• Chen, Q., N. N. Huang, J. T. Huang, S. Chen, J. Fan, C. Li, and F. K. Xie. 2009. Sodium benzoate exposure downregulates the expression of tyrosine hydroxylase and dopamine transporter in dopaminergic neurons in developing zebrafish. Birth Defects Res. Part B - Dev. Reprod. Toxicol 86 (2):85–91. doi:10.1002/bdrb.20187.
   PubMedGoogle Scholar
• Chen, T., C. Li, Y. Li, X. Yi, R. Wang, S. M. Y. Lee, and Y. Zheng. 2017. Small-sized mPEG–PLGA Nanoparticles of Schisantherin a with Sustained Release for Enhanced Brain Uptake and Anti-Parkinsonian Activity. ACS Appl. Mater. Interfaces 9 (11):9516–27. doi:10.1021/acsami.7b01171.
   PubMed Web of Science ®Google Scholar
• Chen, T., Y. Li, C. Li, X. Yi, R. Wang, S. M. Y. Lee, and Y. Zheng. 2017. Pluronic P85/F68 micelles of baicalein could interfere with mitochondria to overcome MRP2-mediated efflux and offer improved anti-parkinsonian activity. Mol. Pharm. 14 (10):3331–42. doi:10.1021/acs.molpharmaceut.7b00374.
   PubMed Web of Science ®Google Scholar
• Chen, Z., C. Yu, I. A. Khan, Y. Tang, S. Liu, and M. Yang. 2020. Toxic effects of different-sized graphene oxide particles on zebrafish embryonic development. Ecotoxicol. Environ. Saf. 197:110608. doi:10.1016/j.ecoenv.2020.110608.
   PubMed Web of Science ®Google Scholar
• Chia, S. J., E. K. Tan, and Y. X. Chao. 2020. Historical perspective: Models of Parkinson’s disease. Int. J. Mol. Sci 21 (7):2464. doi:10.3390/ijms21072464.
   PubMed Web of Science ®Google Scholar
• Choi, T. Y., T. I. Choi, Y. R. Lee, S. K. Choe, and C. H. Kim. 2021. Zebrafish as an animal model for biomedical research. Exp. Mol. Med 53 (3):310–17. doi:10.1038/s12276-021-00571-5.
   PubMed Web of Science ®Google Scholar
• Choi, M. S., T. Nakamura, S. J. Cho, X. Han, E. A. Holland, J. Qu, G. A. Petsko, J. R. Yates, R. C. Liddington, and S. A. Lipton. 2014. Transnitrosylation from DJ-1 to PTEN attenuates neuronal cell death in Parkinson’s disease models. J. Neurosci 34 (45):15123–31. doi:10.1523/JNEUROSCI.4751-13.2014.
   PubMed Web of Science ®Google Scholar
• Chong, C. M., D. Ma, C. Zhao, R. J. M. Franklin, Z. Y. Zhou, N. Ai, C. Li, H. Yu, T. Hou, F. Sa, et al. 2015. Discovery of a novel neuroprotectant, BHDPC, that protects against MPP+/MPTP-induced neuronal death in multiple experimental models. Free Radic. Biol. Med. 89:1057–66. doi:10.1016/j.freeradbiomed.2015.08.013.
   PubMed Web of Science ®Google Scholar
• Christensen, C., H. Porsteinsson, V. H. Maier, and K. E. Karlsson. 2020. Multi-parameter behavioral phenotyping of the MPP+ model of Parkinson’s disease in zebrafish. Front Behav. Neurosci. 14:1–14. doi:10.3389/fnbeh.2020.623924.
   PubMed Web of Science ®Google Scholar
• Cicchetti, F., J. Drouin-Ouellet, and R. E. Gross. 2009. Environmental toxins and Parkinson’s disease: What have we learned from pesticide-induced animal models? Trends Pharmacol. Sci. 30 (9):475–83. doi:10.1016/j.tips.2009.06.005.
   PubMed Web of Science ®Google Scholar
• Cleal, M., B. D. Fontana, M. Double, R. Mezabrovschi, L. Parcell, E. Redhead, and M. O. Parker. 2021. Dopaminergic modulation of working memory and cognitive flexibility in a zebrafish model of aging-related cognitive decline. Neurobiol. Aging 102:1–16. doi:10.1016/j.neurobiolaging.2021.02.005.
   PubMed Web of Science ®Google Scholar
• Cochemé, H. M., and M. P. Murphy. 2008. Complex I is the major site of mitochondrial superoxide production by paraquat. J. Biol. Chem. 283 (4):1786–98. doi:10.1074/jbc.M708597200.
   PubMed Web of Science ®Google Scholar
• Criswell, S. R., J. S. Perlmutter, J. L. Huang, N. Golchin, H. P. Flores, A. Hobson, M. Aschner, K. M. Erikson, H. Checkoway, and B. A. Racette. 2012. Basal ganglia intensity indices and diffusion weighted imaging in manganese-exposed welders. Occup. Environ. Med. 69 (6):437–43. doi:10.1136/oemed-2011-100119.
   PubMed Web of Science ®Google Scholar
• Cronin, A., and M. Grealy. 2017. Neuroprotective and neuro-restorative effects of minocycline and rasagiline in a zebrafish 6-hydroxydopamine model of Parkinson’s Disease. Neuroscience 367:34–46. doi:10.1016/j.neuroscience.2017.10.018.
   PubMed Web of Science ®Google Scholar
• Crossley, N. A., E. Sena, J. Goehler, J. Horn, B. Van Der Worp, P. M. W. Bath, M. MacLeod, and U. Dirnagl. 2008. Empirical evidence of bias in the design of experimental stroke studies: A metaepidemiologic approach. Stroke 39 (3):929–34. doi:10.1161/STROKEAHA.107.498725.
   PubMed Web of Science ®Google Scholar
• Cui, G., L. Shan, Y. Chen, H. Zhou, Y. Wang, and S. M. Y. Lee. 2016. A new danshensu derivative protects against 6-hydroxydopamine-induced neurotoxicity in vitro and in vivo. Am. J. Chin. Med. 44 (07):1349–61. doi:10.1142/S0192415X16500750.
   PubMedGoogle Scholar
• Decourt, M., H. Jiménezurbieta, M. Benoit-Marand, and P. O. Fernagut. 2021. Neuropsychiatric and cognitive deficits in Parkinson’s disease and their modeling in rodents. Biomedicines 9 (6):684. doi:10.3390/biomedicines9060684.
   PubMed Web of Science ®Google Scholar
• De Lau, L. M. L., P. C. L. M. Giesbergen, M. C. De Rijk, A. Hofman, P. J. Koudstaal, and M. M. B. Breteler. 2004. Incidence of parkinsonism and Parkinson disease in a general population: The Rotterdam study. Neurology 63:1240–44. doi:10.1212/01.WNL.0000140706.52798.BE.
   PubMed Web of Science ®Google Scholar
• Díaz-Casado, M. E., E. Lima, J. A. García, C. Doerrier, P. Aranda, R. K. A. Sayed, A. Guerra-Librero, G. Escames, L. C. López, and D. Acuña-Castroviejo. 2016. Melatonin rescues zebrafish embryos from the parkinsonian phenotype restoring the parkin/pink1/dj-1/MUL1 network. J. Pineal Res. 61 (1):96–107. doi:10.1111/jpi.12332.
   PubMed Web of Science ®Google Scholar
• Díaz-Casado, M. E., I. Rusanova, P. Aranda, M. Fernández-Ortiz, R. K. A. Sayed, B. I. Fernández-Gil, A. Hidalgo-Gutiérrez, G. Escames, L. C. López, and D. Acuña-Castroviejo. 2018. In vivo determination of mitochondrial respiration in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated zebrafish reveals the efficacy of melatonin in restoring mitochondrial normalcy. Zebrafish 15 (1):15–26. doi:10.1089/zeb.2017.1479.
   PubMed Web of Science ®Google Scholar
• Ding, L., W. Nan, X. Zhu, X. Li, L. Zhou, H. Chen, L.Yu, F. Ullah Khan, H. Zhong and X. Shi. (2019). Rapamycin and FK506 derivative TH2849 could ameliorate neurodegenerative diseases through autophagy with low immunosuppressive effect. CNS Neurosci. Ther. 25 (4):452–464. doi:10.1111/cns.13062.
   PubMed Web of Science ®Google Scholar
• Dipp, V. R., S. Valles, H. Ortiz-Kerbertt, J. V. Suarez, and U. Bardullas. 2018. Neurobehavioral alterations in zebrafish due to long-term exposure to low doses of inorganic arsenic. Zebrafish 15:575–85. doi:10.1089/zeb.2018.1627.
   PubMed Web of Science ®Google Scholar
• Dixon, S. J., K. M. Lemberg, M. R. Lamprecht, R. Skouta, E. M. Zaitsev, C. E. Gleason, D. N. Patel, A. J. Bauer, A. M. Cantley, W. S. Yang, et al. 2012. Ferroptosis: An iron-dependent form of nonapoptotic cell death. Cell, 149,(5):1060–72. doi:10.1016/j.cell.2012.03.042.
   PubMed Web of Science ®Google Scholar
• Dong, H., H. Wu, C. Bai, K. Ye, L. Mao, Y. Lei, Y. Liu, H. Xu, J. Lin, J. Zhu, et al. 2022. Transient MPTP exposure at a sensitive developmental window altered gut microbiome and led to male-biased motor and social behavioral deficits in adult zebrafish. NeuroToxicology 91:360–68. doi:10.1016/j.neuro.2022.06.008.
   PubMed Web of Science ®Google Scholar
• Doyle, J. M., and R. P. Croll. 2022. A critical review of zebrafish models of Parkinson’s disease. 2022. Front Pharmacol. 13:835827. doi:10.3389/fphar.2022.835827.
   PubMed Web of Science ®Google Scholar
• Drummond, N. J., N. O. Davies, J. E. Lovett, M. R. Miller, G. Cook, T. Becker, C. G. Becker, D. B. McPhail, and T. Kunath. 2017. A synthetic cell permeable antioxidant protects neurons against acute oxidative stress. Sci. Rep 7 (1):1–12. doi:10.1038/s41598-017-12072-5.
   PubMedGoogle Scholar
• Duavy, S. M., A. Ecker, G. T. Salazar, J. Loreto, J. G. M. Costa, and N. Vargas Barbosa. 2019. Pequi enriched diets protect Drosophila melanogaster against paraquat-induced locomotor deficits and oxidative stress. J. Toxicol. Environ. Health. A 82 (11):664–77. doi:10.1080/15287394.2019.1642277.
   PubMed Web of Science ®Google Scholar
• Dun, Y., G. Li, Y. Yang, Z. Xiong, M. Feng, M. Wang, Y. Zhang, J. Xiang, and R. Ma. 2012. Inhibition of the canonical wnt pathway by dickkopf-1 contributes to the neurodegeneration in 6-OHDA-lesioned rats. Neurosci. Lett. 525 (2):83–88. doi:10.1016/j.neulet.2012.07.030.
   PubMed Web of Science ®Google Scholar
• du Sert, P. N., V. Hurst, A. Ahluwalia, S. Alam, T. A. M, M. Baker, W. J. Browne, A. Clark, I. C. Cuthill, U. Dirnagl, et al. 2020. The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research. PLoS Biol., 18,(7):e3000410. doi:10.1371/journal.pbio.3000410.
   PubMed Web of Science ®Google Scholar
• Espadas, I., S. Darmopil, E. Vergaño-Vera, O. Ortiz, I. Oliva, C. Vicario-Abejón, E. D. Martín, and R. Moratalla. 2012. L-DOPA-induced increase in TH-immunoreactive striatal neurons in parkinsonian mice: Insights into regulation and function. Neurobiol. Dis. 48 (3):271–81. doi:10.1016/j.nbd.2012.07.012.
   PubMed Web of Science ®Google Scholar
• Farrell, T. C., C. L. Cario, C. Milanese, A. Vogt, J. Jeong and E. A. Burton. 2011. Evaluation of spontaneous propulsive movement as a screening tool to detect rescue of Parkinsonism phenotypes in zebrafish models. Neurobiol. Dis. 44:9–18. doi:10.1016/j.nbd.2011.05.016.
   PubMed Web of Science ®Google Scholar
• Feng, C. W., N. F. Chen, Z. H. Wen, W. Y. Yang, H. M. Kuo, P. J. Sung, J. H. Su, S. Y. Cheng, and W. F. Chen. 2019. In vitro and in vivo neuroprotective effects of stellettin b through anti-apoptosis and the nrf2/ho-1 pathway. Mar. Drugs 17 (6):315. doi:10.3390/md17060315.
   PubMed Web of Science ®Google Scholar
• Feng, C. W., H. C. Hung, S. Y. Huang, C. H. Chen, Y. R. Chen, C. Y. Chen, S. N. Yang, H. M. D. Wang, P. J. Sung, J. H. Sheu, et al. 2016. Neuroprotective effect of the marine-derived compound 11-dehydrosinulariolide through DJ-1-related pathway in in vitro and in vivo models of Parkinson’s disease. Mar. Drugs, 14,(10):1–18. doi:10.3390/md14100187
   Web of Science ®Google Scholar
• Feng, C. W., Z. H. Wen, S. Y. Huang, H. C. Hung, C. H. Chen, S. N. Yang, N. F. Chen, H. M. Wang, C. Der Hsiao, and W. F. Chen. 2014. Effects of 6-hydroxydopamine exposure on motor activity and biochemical expression in zebrafish (Danio Rerio) larvae. Zebrafish 11 (3):227–39. doi:10.1089/zeb.2013.0950.
   PubMed Web of Science ®Google Scholar
• Filippi, A., T. Mueller, and W. Driever. 2014. Vglut2 and Gad Expression reveal distinct patterns of dual GABAergic versus glutamatergic cotransmitter phenotypes of dopaminergic and noradrenergic neurons in the zebrafish brain. J. Comp. Neurol. 522:2019–37. doi:10.1002/cne.23524.
   PubMed Web of Science ®Google Scholar
• Fleming, A., A. Diekmann, and P. Goldsmith. 2013. Functional characterisation of the maturation of the blood-brain barrier in larval zebrafish. PLoS One 8 (10):e77548. doi:10.1371/journal.pone.0077548.
   PubMed Web of Science ®Google Scholar
• Franco-Iborra, S., M. Vila, and C. Perier. 2016. The Parkinson disease mitochondrial hypothesis: Where are we at? Neurosci. 22 (3):266–77. doi:10.1177/1073858415574600.
   Google Scholar
• Freire, C., and S. Koifman. 2012. Pesticide exposure and Parkinson’s disease: Epidemiological evidence of association. NeuroToxicology 33 (5):947–71. doi:10.1016/j.neuro.2012.05.011.
   PubMed Web of Science ®Google Scholar
• Friedrich, R. W., G. A. Jacobson, and P. Zhu. 2010. Circuit neuroscience in zebrafish. Curr. Bio 20 (8):R371–81. doi:10.1016/j.cub.2010.02.039.
   PubMed Web of Science ®Google Scholar
• Geier, M. C., D. J. Minick, L. Truong, S. Tilton, P. Pande, K. A. Anderson, J. Teeguardan, and R. L. Tanguay. 2018. Systematic developmental neurotoxicity assessment of a representative pah superfund mixture using zebrafish. Toxicol. Appl. Pharmacol. 354:115–25. doi:10.1016/j.taap.2018.03.029.
   PubMed Web of Science ®Google Scholar
• Gerlai, R. 2020. Evolutionary conservation, translational relevance and cognitive function: The future of zebrafish in behavioral neuroscience. Neurosci. Biobehav. Rev 116:426–35. doi:10.1016/j.neubiorev.2020.07.009.
   PubMed Web of Science ®Google Scholar
• Gonzalezpolo, R., G. Soler, A. Rodriguezmartin, J. Moran, and J. Fuentes. 2004. Protection against MPP+ neurotoxicity in cerebellar granule cells by antioxidants. Cell Biol. Int. 28 (5):373–80. doi:10.1016/j.cellbi.2004.03.005.
   PubMed Web of Science ®Google Scholar
• Grandi, L. C., G. Di Giovanni, and S. Galati. 2018. Animal models of early-stage Parkinson’s disease and acute dopamine deficiency to study compensatory neurodegenerative mechanisms. 2018. J. Neurosci. Methods 308:205–18. doi:10.1016/j.jneumeth.2018.08.012.
   PubMed Web of Science ®Google Scholar
• Gu, J., M. Guo, C. Huang, X. Wang, Y. Zhu, L. Wang, Z. Wang, L. Zhou, D. Fan, L. Shi, et al. 2021. Titanium dioxide nanoparticle affects motor behavior, neurodevelopment and axonal growth in zebrafish (Danio rerio) larvae. Sci. Total Environ. 754:142315. doi:10.1016/j.scitotenv.2020.142315.
   PubMed Web of Science ®Google Scholar
• Gu, J., M. Guo, X. Yin, C. Huang, L. Qian, L. Zhou, Z. Wang, L. Wang, L. Shi, and G. Ji. 2022. A systematic comparison of neurotoxicity of bisphenol a and its derivatives in zebrafish. Sci. Total Environ. 805:150210. doi:10.1016/j.scitotenv.2021.150210.
   PubMed Web of Science ®Google Scholar
• Guo, Z., H. Miyoshi, T. Komyoji, T. Haga, and T. Fujita. 1991. Uncoupling activity of a newly developed fungicide, fluazinam [3-chloro-N-(3-chloro-2,6-dinitro-4-trifluoromethylphenyl)-5-trifluoromethyl-2-pyridinamine]. Biochim. Biophy. Acta - Bioenerg 1056 (1):89–92. doi:10.1016/S0005-2728(05)80077-5.
   Web of Science ®Google Scholar
• Guo, S., S. W. Wilson, S. Cooke, A. B. Chitnis, W. Driever, and A. Rosenthal. 1999. Mutations in the zebrafish unmask shared regulatory pathways controlling the development of catecholaminergic neurons. Dev. Biol. 208 (2):473–87. doi:10.1006/dbio.1999.9204.
   PubMed Web of Science ®Google Scholar
• Guo, B., D. Xu, H. Duan, J. Du, Z. Zhang, S. W. Y. Lee, and Y. Wang. 2014. Therapeutic effects of multifunctional tetramethylpyrazine nitrone on models of Parkinson’s disease in vitro and in vivo. Biol. Pharm. Bull. 37 (2):274–85. doi:10.1248/bpb.b13-00743.
   PubMed Web of Science ®Google Scholar
• Haces, M. L., T. Montiel, and L. Massieu. 2010. Selective vulnerability of brain regions to oxidative stress in a non-coma model of insulin-induced hypoglycemia. Neuroscience 165 (1):28–38. doi:10.1016/j.neuroscience.2009.10.003.
   PubMed Web of Science ®Google Scholar
• Ham, A., D. W. Kim, K. H. Kim, S. J. Lee, K. B. Oh, J. Shin, and W. Mar. 2013. Reynosin protects against neuronal toxicity in dopamine-induced SH-SY5Y cells and 6-hydroxydopamine-lesioned rats as models of Parkinson’s disease: Reciprocal up-regulation of E6-AP and down-regulation of α-synuclein. Brain Res. 1524:54–61. doi:10.1016/j.brainres.2013.05.036.
   PubMed Web of Science ®Google Scholar
• Heinz, S., A. Freyberger, B. Lawrenz, L. Schladt, G. Schmuck, and H. Ellinger-Ziegelbauer. 2017. Mechanistic investigations of the mitochondrial complex i inhibitor rotenone in the context of pharmacological and safety evaluation. Sci. Rep. 7 (1):45465. doi:10.1038/srep45465.
   PubMedGoogle Scholar
• Horzmann, K. A., and J. L. Freeman. 2018. Making waves: New developments in toxicology with the zebrafish. Toxicol. Sci 163 (1):5–12. doi:10.1093/toxsci/kfy044.
   PubMed Web of Science ®Google Scholar
• Hsu, C. H., Z. H. Wen, C. S. Lin, and C. Chakraborty. 2007. The zebrafish model: Use in studying cellular mechanisms for a spectrum of clinical disease entities. Current Neurovas. Res, 4 (2):111–20. doi:10.2174/156720207780637234.
   PubMed Web of Science ®Google Scholar
• Huang, X., Y. Liang, Y. Qing, D. Chen, and N. Shi. 2019. Proteasome inhibition by MG-132 protects against deltamethrin-induced apoptosis in rat hippocampus. Life Sci. 220:76–83. doi:10.1016/j.lfs.2019.01.041.
   PubMed Web of Science ®Google Scholar
• Hu, Q., F. Guo, F. Zhao, and Z. Fu. 2017. Effects of titanium dioxide nanoparticles exposure on parkinsonism in zebrafish larvae and PC12. Chemosphere 173:373–79. doi:10.1016/j.chemosphere.2017.01.063.
   PubMed Web of Science ®Google Scholar
• Hu, Q., and G. Wang. 2016. Mitochondrial dysfunction in Parkinson’s disease. Transl. Neurodegener 5 (1):14. doi:10.1186/s40035-016-0060-6.
   PubMed Web of Science ®Google Scholar
• Ibrahim, A. M., L. Chauhan, A. Bhardwaj, A. Sharma, F. Fayaz, B. Kumar, M. Alhashmi, N. AlHajri, M. S. Alam, and F. H. Pottoo. 2022. Brain-derived neurotropic factor in neurodegenerative disorders. Biomedicines 10 (5):1143. doi:10.3390/biomedicines10051143.
   PubMed Web of Science ®Google Scholar
• Ijomone, O. M., O. M. Aluko, C. O. A. Okoh, A. C. Martins, and M. Aschner. 2019. Role for calcium signaling in manganese neurotoxicity. J. Trace Elem. Med. Biol 56:146–55. doi:10.1016/j.jtemb.2019.08.006.
   PubMed Web of Science ®Google Scholar
• Jeong, J. Y., H. B. Kwon, J. C. Ahn, D. Kang, S. H. Kwon, J. A. Park, and K. W. Kim. 2008. Functional and developmental analysis of the blood–brain barrier in zebrafish. Brain Res. Bull. 75 (5):619–28. doi:10.1016/j.brainresbull.2007.10.043.
   PubMed Web of Science ®Google Scholar
• Joseph, T. P., N. Jagadeesan, L. Y. Sai, S. L. Lin, S. Sahu, and M. Schachner. 2020. Adhesion Molecule L1 Agonist mimetics protect against the pesticide paraquat-induced locomotor deficits and biochemical alterations in zebrafish. Front. Neurosci. 14:1–15. doi:10.3389/fnins.2020.00458.
   PubMed Web of Science ®Google Scholar
• Kacew, S., and A. W. Hayes. 2020. Absence of neurotoxicity and lack of neurobehavioral consequences due to exposure to tetrabromobisphenol a (TBBPA) exposure in humans, animals and zebrafish. Arch. Toxicol. 94 (1):59–66. doi:10.1007/s00204-019-02627-y.
   PubMed Web of Science ®Google Scholar
• Kalueff, A. V., D. J. Echevarria, and A. M. Stewart. 2014. Gaining translational momentum: More zebrafish models for neuroscience research. Prog. Neuropsychopharmacol. Biol. Psychiatry 55:1–6. doi:10.1016/j.pnpbp.2014.01.022.
   PubMed Web of Science ®Google Scholar
• Kalueff, A. V., M. Gebhardt, A. M. Stewart, J. M. Cachat, M. Brimmer, J. S. Chawla, C. Craddock, E. J. Kyzar, A. Roth, S. Landsman, et al. 2013. Towards a comprehensive catalog of zebrafish behavior 1.0 and beyond. Zebrafish, 10,(1):70–86. doi:https://doi.org/10.1089/zeb.2012.0861
   PubMed Web of Science ®Google Scholar
• Kalueff, A. V., A. M. Stewart, and R. Gerlai. 2014. Zebrafish as an emerging model for studying complex brain disorders. Trends Pharmacol. Sci. 35 (2):63–75. doi:10.1016/j.tips.2013.12.002.
   PubMed Web of Science ®Google Scholar
• Kao, C. J., W. F. Chen, B. L. Guo, C. W. Feng, H. C. Hung, W. Y. Yang, C. S. Sung, K. H. Tsui, H. Chu, N. F. Chen, et al. 2017. The 1-tosylpentan-3-one protects against 6-hydroxydopamine-induced neurotoxicity. Int. J. Mol. Sci 18 (5):1–25. doi:10.3390/ijms18051096.
   Web of Science ®Google Scholar
• Kawakami, F., N. Shimada, E. Ohta, G. Kagiya, R. Kawashima, T. Maekawa, H. Maruyama, and T. Ichikawa. 2014. Leucine-rich repeat kinase 2 regulates tau phosphorylation through direct activation of glycogen synthase kinase-3β. FEBS J. 281:3–13. doi:10.1111/febs.12579.
   PubMed Web of Science ®Google Scholar
• Kesh, S., R. R. Kannan, and A. Balakrishnan. 2021a. Naringenin alleviates 6-hydroxydopamine induced Parkinsonism in SHSY5Y cells and zebrafish model. Comp. Biochem. Physiol. C: Toxicol. Pharmacol. 239:108893. doi:10.1016/j.cbpc.2020.108893.
   PubMed Web of Science ®Google Scholar
• Kesh, S., R. R. Kannan, K. Sivaji, and A. Balakrishnan. 2021b. Hesperidin downregulates kinases lrrk2 and gsk3β in a 6-OHDA induced Parkinson’s disease model. Neurosci. Lett. 740:135426. doi:10.1016/j.neulet.2020.135426.
   PubMed Web of Science ®Google Scholar
• Khalili, A., E. van Wijngaarden, G. R. Zoidl, and P. Rezai. 2020. Multi-phenotypic and bi-directional behavioral screening of zebrafish larvae. Integr. Bio: Quant. Biosci. Nano. Macro 12 (8):211–20. doi:10.1093/intbio/zyaa016.
   Google Scholar
• Kim, S. S., K. S. Hwang, H. Kan, J. Y. Yang, Y. Son, D. S. Shin, B. H. Lee, C. H. Chae, and M. A. Bae. 2022. Neurotoxicological profiling of paraquat in zebrafish model. Neurochem. Res. 47 (8):2294–306. doi:10.1007/s11064-022-03615-y.
   PubMed Web of Science ®Google Scholar
• Kin, K., T. Yasuhara, M. Kameda, and I. Date. 2019. Animal models for Parkinson’s disease research: Trends in the 2000s. Int. J. Mol . Sci. 20 (21):5402. doi:10.3390/ijms20215402.
   PubMed Web of Science ®Google Scholar
• Kozioł, E., K. Skalicka-Woźniak, A. Michalak, K. Kaszubska, and B. Budzyńska. 2021. Xanthotoxin reverses Parkinson’s disease-like symptoms in zebrafish larvae and mice models: A comparative study. Pharmacol. Rep. 73 (1):122–29. doi:10.1007/s43440-020-00136-9.
   PubMed Web of Science ®Google Scholar
• Kumar, S., R. Meena, and R. Paulraj. 2016. Role of macrophage (M1 and M2) in titanium-dioxide nanoparticle-induced oxidative stress and inflammatory response in rat. Appl. Biochem. Biotechnol. 180 (7):1257–75. doi:10.1007/s12010-016-2165-x.
   PubMed Web of Science ®Google Scholar
• Lam, C. S., V. Korzh, and U. Strahle. 2005. Zebrafish embryos are susceptible to the dopaminergic neurotoxin MPTP. Eur. J. Neurosci. 21 (6):1758–62. doi:10.1111/j.1460-9568.2005.03988.x.
   PubMed Web of Science ®Google Scholar
• Leandro, L. P., R. Siqueira de Mello, D. G. da Costa-Silva, M. E. M. Nunes, A. Lopes, I. K. Martins, T. Posser, and J. L. Franco. 2021. Behavioral changes occur earlier than redox alterations in developing zebrafish exposed to Mancozeb. Environ. Pollut. 268:115783. doi:10.1016/j.envpol.2020.115783.
   PubMed Web of Science ®Google Scholar
• Li, S., H. Chen, X. Yang, D. Bardelang, I. W. Wyman, J. Wan, S. M. Y. Lee, and R. Wang. 2015. Supramolecular inhibition of neurodegeneration by a synthetic receptor. ACS Med. Chem. Lett. 6 (12):1174–78. doi:10.1021/acsmedchemlett.5b00372.
   PubMed Web of Science ®Google Scholar
• Li, C., B. Tang, Y. Feng, F. Tang, M. Pui-Man Hoi, Z. Su, and S. Ming-Yuen Lee. 2018a. Pinostrobin exerts neuroprotective actions in neurotoxin-induced Parkinson’s disease models through Nrf2 induction. J. Agric. Food Chem. 66 (31):8307–18. doi:10.1021/acs.jafc.8b02607.
   PubMed Web of Science ®Google Scholar
• Liu, X., N. Yamada, and T. Osawa. 2014. Amide-type adduct of dopamine-plausible cause of Parkinson’s disease. Subcell. Bioche 77:49–60.
   PubMedGoogle Scholar
• Liu, Y., Y. Zhao, B. Sun, and C. Chen. 2013. Understanding the toxicity of carbon nanotubes. Acc. Chem. Res. 46 (3):702–13. doi:10.1021/ar300028m.
   PubMed Web of Science ®Google Scholar
• Li, M., F. Zhou, T. Xu, H. Song, and B. Lu. 2018b. Acteoside protects against 6-OHDA-induced dopaminergic neuron damage via Nrf2-ARE signaling pathway. Food. Che. Toxicol 119:6–13. doi:10.1016/j.fct.2018.06.018.
   PubMed Web of Science ®Google Scholar
• Lulla, A., L. Barnhill, G. Bitan, M. I. Ivanova, B. Nguyen, K. O’donnell, M. C. Stahl, C. Yamashiro, F. -G. Klärner, T. Schrader, et al. 2016. Neurotoxicity of the Parkinson disease-associated pesticide ziram is synuclein-dependent in zebrafish embryos. Environ. Health Perspect., 124,(11):1766–75. doi:10.1289/EHP141.
   PubMed Web of Science ®Google Scholar
• Ma, Q. 2013. Role of NrF2 in oxidative stress and toxicity. 2013. Annu. Rev. Pharmacol. Toxicol. 53 (1):401–26. doi:10.1146/annurev-pharmtox-011112-140320.
   PubMed Web of Science ®Google Scholar
• Macleod, M. R., A. Lawson McLean, A. Kyriakopoulou, S. Serghiou, A. de Wilde, N. Sherratt, T. Hirst, R. Hemblade, Z. Bahor, C. Nunes-Fonseca, et al. 2015. Risk of bias in reports of in vivo research: A focus for improvement. PLoS Biol., 13,(10):e1002273. doi:10.1371/journal.pbio.1002273.
   PubMed Web of Science ®Google Scholar
• Macleod M. R., O’Collins T., Howells D. W. and Donnan G. A. 2004. Pooling of Animal Experimental Data Reveals Influence of Study Design and Publication Bias. Stroke 35: 1203–1208. 10.1161/01.STR.0000125719.25853.20
   PubMed Web of Science ®Google Scholar
• Manjunatha, B., E. Seo, S. H. Park, S.R. R. Kundapur, and J.S. Lee. 2021. Pristine graphene and graphene oxide induce multi-organ defects in zebrafish (Danio rerio) larvae/juvenile: An in vivo study. Environ. Sci. Pollut. Res. Int. 28 (26):34664–75. doi:10.1007/s11356-021-13058-7.
   PubMed Web of Science ®Google Scholar
• Manning-Bog, A. B., A. L. McCormack, J. Li, V. N. Uversky, A. L. Fink, and D. A. Di Monte. 2002. The herbicide paraquat causes up-regulation and aggregation of α-synuclein in mice. J. Biol. Chem. 277 (3):1641–44. doi:10.1074/jbc.C100560200.
   PubMed Web of Science ®Google Scholar
• Maries, E., B. Dass, T. J. Collier, J. H. Kordower, and K. Steece-Collier. 2003. The role of α-synuclein in Parkinson’s disease: Insights from animal models. Nat. Rev. Neurosci. 4 (9):727–38. doi:10.1038/nrn1199.
   PubMed Web of Science ®Google Scholar
• Martel, S., J. Y. Keow, and M. Ekker. 2015. Rotenone neurotoxicity causes dopamine neuron loss in zebrafish. Univ. Ottawa J. Med 15 (2):16–21. doi:10.18192/uojm.v5i2.1413.
   Google Scholar
• Martí, Y., F. Matthaeus, T. Lau, and P. Schloss. 2017. Methyl-4-phenylpyridinium (MPP+) differentially affects monoamine release and re-uptake in murine embryonic stem cell-derived dopaminergic and serotonergic neurons. Mole. Cellular Neurosci 83:37–45. doi:10.1016/j.mcn.2017.06.009.
   PubMed Web of Science ®Google Scholar
• Matsui, H., A. Sugie, and J. Kanungo. 2017. An optimized method for counting dopaminergic neurons in zebrafish. PLoS. One 12 (9):1–12. doi:10.1371/journal.pone.0184363.
   Web of Science ®Google Scholar
• McDowell, K., and M. F. Chesselet. 2012. Animal models of the non-motor features of Parkinson’s disease. Neurobiol. Dis. 46 (3):597–606. doi:10.1016/j.nbd.2011.12.040.
   PubMed Web of Science ®Google Scholar
• McLean, D. L., and J. R. Fetcho. 2004. Ontogeny and innervation patterns of dopaminergic, noradrenergic, and serotonergic neurons in larval zebrafish. J. Comp. Neurol. 480 (1):38–56. doi:10.1002/cne.20280.
   PubMed Web of Science ®Google Scholar
• Melo, K. M., R. Oliveira, C. K. Grisolia, I. Domingues, J. C. Pieczarka, J. de Souza Filho, and C. Y. Nagamachi. 2015. Short-term exposure to low doses of rotenone induces developmental, biochemical, behavioral, and histological changes in fish. Environ. Sci. Pollut. Res 22 (18):13926–38. doi:10.1007/s11356-015-4596-2.
   PubMed Web of Science ®Google Scholar
• Meredith, G. E., S. Totterdell, E. Petroske, K. Santa Cruz, R. C. Callison Jr, and Y. S. Lau. 2002. Lysosomal malfunction accompanies alpha-synuclein aggregation in a progressive mouse model of Parkinson’s disease. Brain Res. 956 (1):156–65. doi:10.1016/s0006-8993(02)03514-x.
   PubMed Web of Science ®Google Scholar
• Milanese, C., J. J. Sager, Q. Bais, T. C. Farrells, J. R. Cannons, J. T. Greenamyre, and E. A. Burtons. 2012. Hypokinesia and reduced dopamine levels in zebrafish lacking β- and γ1-synucleins. J. Biol. Chem. 287 (5):2971–83. doi:10.1074/jbc.M111.308312.
   PubMed Web of Science ®Google Scholar
• Mitra, S., N. Chakrabarti, and A. Bhattacharyya. 2011. Differential regional expression patterns of α-synuclein, TNF-α, and IL-1β; and variable status of dopaminergic neurotoxicity in mouse brain after Paraquat treatment. J. Neuroinflammation 8 (1):163. doi:10.1186/1742-2094-8-163.
   PubMedGoogle Scholar
• Moher, D., A. Liberati, J. Tetzlaff, and D. G. Altman. 2009. Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement. J. Clin. Epidemiol. 62 (10):1006–12. doi:10.1016/j.jclinepi.2009.06.005.
   PubMed Web of Science ®Google Scholar
• Moretto, A., and C. Colosio. 2011. Biochemical and toxicological evidence of neurological effects of pesticides: The example of Parkinson’s disease. NeuroToxicol. 32 (4):383–91. doi:10.1016/j.neuro.2011.03.004.
   PubMed Web of Science ®Google Scholar
• Murphy, M. P. 2009. How mitochondria produce reactive oxygen species. Biochem. J. 417 (1):1–13. doi:10.1042/BJ20081386.
   PubMed Web of Science ®Google Scholar
• Nasuti, C., G. Brunori, P. Eusepi, L. Marinelli, R. Ciccocioppo, and R. Gabbianelli. 2017. Early life exposure to permethrin: A progressive animal model of Parkinson’s disease. J. Pharmacol. Toxicol. Methods 83:80–86. doi:10.1016/j.vascn.2016.10.003.
   PubMed Web of Science ®Google Scholar
• Naz, F., and Y. H. Siddique. 2021. Drosophila melanogaster a versatile model of Parkinson’s disease. CNS & Neurol. Dis. Drug Targets 20 (6):487–530. doi:10.2174/1871527320666210208125912.
   PubMed Web of Science ®Google Scholar
• Nellore, J., and P. Nandita. 2015. Paraquat exposure induces behavioral deficits in larval zebrafish during the window of dopamine neurogenesis. Toxicol. Rep 2:950–56. doi:10.1016/j.toxrep.2015.06.007.
   PubMed Web of Science ®Google Scholar
• Niedzielska, E., I. Smaga, M. Gawlik, A. Moniczewski, P. Stankowicz, J. Pera, and M. Filip. 2016. Oxidative stress in neurodegenerative diseases. Mol. Neurobiol. 53 (6):4094–125. doi:10.1007/s12035-015-9337-5.
   PubMed Web of Science ®Google Scholar
• Ohnuki, T., A. Nakamura, S. Okuyama, and S. Nakamura. 2010. Gene expression profiling in progressively MPTP-lesioned macaques reveals molecular pathways associated with sporadic Parkinson’s disease. Brain Res. 1346:26–42. doi:10.1016/j.brainres.2010.05.066.
   PubMed Web of Science ®Google Scholar
• Pantoja, C., J. Larsch, E. Laurell, G. Marquart, M. Kunst, and H. Baier. 2020. Rapid effects of selection on brain-wide activity and behavior. Curr. Bio 30 (18):3647–3656.e3. doi:10.1016/j.cub.2020.06.086.
   PubMed Web of Science ®Google Scholar
• Panula, P., Y. C. Chen, M. Priyadarshini, H. Kudo, S. Semenova, M. Sundvik, and V. Sallinen. 2010. The comparative neuroanatomy and neurochemistry of zebrafish CNS systems of relevance to human neuropsychiatric diseases. Neurobiol. Dis. 40 (1):46–57. doi:10.1016/j.nbd.2010.05.010.
   PubMed Web of Science ®Google Scholar
• Park, J. -S., R. L. Davis, and C. M. Sue. 2018. Mitochondrial dysfunction in Parkinson’s disease: New mechanistic insights and therapeutic perspectives. Curr. Neurol Neurosci. Rep. 18 (5):21. doi:10.1007/s11910-018-0829-3.
   PubMed Web of Science ®Google Scholar
• Parng, C., N. M. Roy, C. Ton, Y. Lin, and P. McGrath. 2007. Neurotoxicity assessment using zebrafish. J. Pharmacol. Toxicol. Methods 55 (1):103–12. doi:10.1016/j.vascn.2006.04.004.
   PubMedGoogle Scholar
• Peters, J. L., A. J. Sutton, D. R. Jones, L. Rushton, and K. R. Abrams. 2006. A systematic review of systematic reviews and meta-analyses of animal experiments with guidelines for reporting. J. Environ. Sci. Health, Part B 41 (7):1245–58. doi:10.1080/03601230600857130.
   PubMed Web of Science ®Google Scholar
• Pinho, B. R., S. D. Reis, P. Guedes-Dias, A. Leitão-Rocha, C. Quintas, P. Valentão, P. B. Andrade, M. M. Santos, and J.M.A. Oliveira. 2016. Pharmacological modulation of HDAC1 and HDAC6 in vivo in a zebrafish model: Therapeutic implications for Parkinson’s disease. Pharmacol. Res 103:328–39. doi:10.1016/j.phrs.2015.11.024.
   PubMed Web of Science ®Google Scholar
• Pinho, B. R., S. D. Reis, R. C. Hartley, M. P. Murphy, and J.M.A. Oliveira. 2019. Mitochondrial superoxide generation induces a parkinsonian phenotype in zebrafish and huntingtin aggregation in human cells. Free Radic. Biol. Med. 130:318–27. doi:10.1016/j.freeradbiomed.2018.10.446.
   PubMed Web of Science ®Google Scholar
• Poewe, W., K. Seppi, C. M. Tanner, G. M. Halliday, P. Brundin, J. Volkmann, A. E. Schrag, and A. E. Lang. 2017. Parkinson disease. Nat. Rev. Dis. Primers 3 (1):17013. doi:10.1038/nrdp.2017.13.
   PubMed Web of Science ®Google Scholar
• Prabhudesai, S., S. Sinha, A. Attar, A. Kotagiri, A. G. Fitzmaurice, R. Lakshmanan, M. I. Ivanova, J. A. Loo, F. -G. Klärner, T. Schrader, et al. 2012. A novel “molecular tweezer” Inhibitor of α-synuclein neurotoxicity in vitro and in vivo. Neurotherapeutics, 9,(2):464–76. doi:10.1007/s13311-012-0105-1
   PubMed Web of Science ®Google Scholar
• Prasuhn, J., and N. Brüggemann. 2021. Gene therapeutic approaches for the treatment of mitochondrial dysfunction in Parkinson’s disease. Genes 12 (11):1840. doi:10.3390/genes12111840.
   PubMed Web of Science ®Google Scholar
• Qian, L., S. Qi, Z. Wang, J. T. Magnuson, D. C. Volz, D. Schlenk, J. Jiang, and C. Wang. 2021. Environmentally relevant concentrations of boscalid exposure affects the neurobehavioral response of zebrafish by disrupting visual and nervous systems. J. Hazard. Mater. 404:124083. doi:10.1016/j.jhazmat.2020.124083.
   PubMed Web of Science ®Google Scholar
• Radad, K., M. Al-Shraim, A. Al-Emam, F. Wang, B. Kranner, W. D. Rausch, and R. Moldzio. 2019. Rotenone: From modelling to implication in Parkinson’s disease. Folia Neuropathol. 57 (4):317–26. doi:10.5114/fn.2019.89857.
   PubMed Web of Science ®Google Scholar
• Randlett, O., M. Haesemeyer, G. Forkin, H. Shoenhard, A. F. Schier, F. Engert, and M. Granato. 2019. Distributed plasticity drives visual habituation learning in larval zebrafish. Curr. Bio 29 (8):1337–1345.e4. doi:10.1016/j.cub.2019.02.039.
   PubMed Web of Science ®Google Scholar
• Razali, K., M. H. Mohd Nasir, N. Othman, A. A. Doolaanea, J. Kumar, W. N. Ibrahim, W.M.Y. Mohamed, and B. Giros. 2022. Characterization of neurobehavioral pattern in a zebrafish 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced model: A 96-hour behavioral study. PLoS. One 17 (10):e0274844. doi:10.1371/journal.pone.0274844.
   PubMedGoogle Scholar
• Razali, K., N. Othman, M. H. Mohd Nasir, A. A. Doolaanea, J. Kumar, W. N. Ibrahim, N. M. Ibrahim, and N. M. Y. Mohamed Wmy. 2021. The promise of the zebrafish model for Parkinson’s disease: Today’s science and tomorrow’s treatment. Front Genet. 12:655550. doi:10.3389/fgene.2021.655550.
   PubMed Web of Science ®Google Scholar
• Reif, D. M., L. Truong, D. Mandrell, S. Marvel, G. Zhang, and R. L. Tanguay. 2016. High-throughput characterization of chemical-associated embryonic behavioral changes predicts teratogenic outcomes. Arch. Toxicol. 90 (6):1459–70. doi:10.1007/s00204-015-1554-1.
   PubMed Web of Science ®Google Scholar
• Reinig, S., W. Driever, and A. B. Arrenberg. 2017. The descending diencephalic dopamine system is tuned to sensory stimuli. Curr. Bio 27 (3):318–33. doi:10.1016/j.cub.2016.11.059.
   PubMed Web of Science ®Google Scholar
• Ren, C., X. Hu, X. Li, and Q. Zhou. 2016. Ultra-trace graphene oxide in a water environment triggers Parkinson’s disease-like symptoms and metabolic disturbance in zebrafish larvae. Biomaterials 93:83–94. doi:10.1016/j.biomaterials.2016.03.036.
   PubMed Web of Science ®Google Scholar
• Rink, E., and M. F. Wullimann. 2001. The teleostean (zebrafish) dopaminergic system ascending to the subpallium (striatum) is located in the basal diencephalon (posterior tuberculum). Brain Res. 889: 316–30. doi:10.1016/S0006-8993(00)03174-7
   PubMed Web of Science ®Google Scholar
• Robea, M. A., I. M. Balmus, A. Ciobica, S. Strungaru, G. Plavan, L. D. Gorgan, A. Savuca, and M. Nicoara. 2020. Parkinson’s disease-induced zebrafish models: Focussing on oxidative stress implications and sleep processes. Oxid. Med. Cell Longev 2020:1370837. doi:10.1155/2020/1370837.
   PubMed Web of Science ®Google Scholar
• Rosa, J. G. S., C. Lima, and M. Lopes-Ferreira. 2022. Zebrafish larvae behavior models as a tool for drug screenings and pre-clinical trials: A review. Int. J. Mol. Sci. 23 (12):6647. doi:10.3390/ijms23126647.
   PubMed Web of Science ®Google Scholar
• Sai, Y., Z. Zou, K. Peng, and Z. Dong. 2012. The Parkinson’s disease-related genes act in mitochondrial homeostasis. Neurosci. Biobehav. Rev. 36 (9):2034–43. doi:10.1016/j.neubiorev.2012.06.007.
   PubMed Web of Science ®Google Scholar
• Sallinen, V., V. Torkko, M. Sundvik, I. Reenilä, D. Khrustalyov, J. Kaslin, and P. Panula. 2009. MPTP and MPP+ target specific aminergic cell populations in larval zebrafish. J. Neurochem. 108 (3):719–31. doi:10.1111/j.1471-4159.2008.05793.x.
   PubMed Web of Science ®Google Scholar
• Saluja, D., R. Jhanji, S. Kaushal, B. Verma, N. Sharma, R. Singh, S. Agrawal, M. Yadav, A. Kumar, C. Singh, et al. 2021. Importance of zebrafish as an efficient research model for the screening of novel therapeutics in neurological disorders. CNS & Neurol. Dis. Drug Targets, 20,(2):145–57. doi:10.2174/187152731-9666201207211927
   PubMed Web of Science ®Google Scholar
• Santos, D. B., D. Colle, E.L. Moreira, M. A. Hort, M. Godoi, G. Le Douaron, A. L. Braga, J. Assreuy, P. P. Michel, R. D. Prediger, et al. 2017. Succinobucol, a non-statin hypocholesterolemic drug, prevents premotor symptoms and nigrostriatal neurodegeneration in an experimental model of Parkinson’s disease. Mol. Neurobiol. 54 (2):1513–30. doi:10.1007/s12035-016-9747-z.
   PubMed Web of Science ®Google Scholar
• Sarasamma, S., G. Audira, P. Samikannu, S. Juniardi, P. Siregar, E. Hao, J. Chen, and C. Hsiao. 2019. Behavioral impairments and oxidative stress in the brain, muscle, and gill caused by chronic exposure of C70 Nanoparticles on adult zebrafish. Int. J. Mol. Sci. 20 (22):5795. doi:10.3390/ijms20225795.
   PubMed Web of Science ®Google Scholar
• Schmidt, N., and B. Ferger. 2001. Neurochemical findings in the MPTP model of Parkinson’s disease. J. Neural Transm. 108 (11):1263–82. doi:10.1007/s007020100004.
   PubMed Web of Science ®Google Scholar
• Schnörr, S. J., P. J. Steenbergen, M. K. Richardson, and D. L. Champagne. 2012. Measuring thigmotaxis in larval zebrafish. Behav. Brain Res. 228 (2):367–74. doi:10.1016/j.bbr.2011.12.016.
   PubMed Web of Science ®Google Scholar
• Schober, A. 2004. Classic toxin-induced animal models of Parkinson’s disease: 6-OHDA and MPTP. Cell Tissue Res. 318 (1):215–24. doi:10.1007/s00441-004-0938-y.
   PubMed Web of Science ®Google Scholar
• Schweitzer, J., H. Lohr, A. Filippi, and W. Driever. 2012. Dopaminergic and noradrenergic circuit development in zebrafish. Dev. Neurobiol. 72 (3):256–68. doi:10.1002/dneu.20911.
   PubMed Web of Science ®Google Scholar
• Semenova, S. A., Y. C. Chen, X. Zhao, H. Rauvala, and P. Panula. 2014. The tyrosine hydroxylase 2 (TH2) system in zebrafish brain and stress activation of hypothalamic cells. Histochem. Cell Biol. 142 (6):619–33. doi:10.1007/s00418-014-1240-z.
   PubMed Web of Science ®Google Scholar
• Shi, X., Y. Du, P. K. S. Lam, R. S. S. Wu, and B. Zhou. 2008. Developmental toxicity and alteration of gene expression in zebrafish embryos exposed to PFOS. Toxicol. Appl. Pharmacol. 230 (1):23–32. doi:10.1016/j.taap.2008.01.043.
   PubMed Web of Science ®Google Scholar
• Shukla, R. K., Y. K. Dhuriya, L. P. Chandravanshi, R. Gupta, P. Srivastava, A. B. Pan, A. Kumar, C. M. Pandey, M. H. Siddiqui, and V. K. Khanna. 2017. Influence of immobilization and forced swim stress on the neurotoxicity of lambda-cyhalothrin in rats: Effect on brain biogenic amines and BBB permeability. NeuroToxicology 60:187–96. doi:10.1016/j.neuro.2016.07.002.
   PubMed Web of Science ®Google Scholar
• Silva, R. F. O., B. R. Pinho, M. M. Santos, and J. M. A. Oliveira. 2022. Disruptions of circadian rhythms, sleep, and stress responses in zebrafish: New infrared-based activity monitoring assays for toxicity assessment. Chemosphere 305:135449. doi:10.1016/j.chemosphere.2022.135449.
   PubMed Web of Science ®Google Scholar
• Simon, D. K., C. M. Tanner, and P. Brundin. 2020. Parkinson disease epidemiology, pathology, genetics, and pathophysiology. Clin. Geriatr. Med. 36 (1):1–12. doi:10.1016/j.cger.2019.08.002.
   PubMed Web of Science ®Google Scholar
• Sun, Y., L. He, T. Wang, W. Hua, H. Qin, J. Wang, L. Wang, W. Gu, T. Li, N. Li, et al. 2020. Activation of p62-Keap1-Nrf2 pathway protects 6-hydroxydopamine-induced ferroptosis in dopaminergic cells. Mol. Neurobiol., 57,(11):4628–41. doi:10.1007/s12035-020-02049-3
   PubMed Web of Science ®Google Scholar
• Surmeier, D. J., J. A. Obeso, and G. M. Halliday. 2017. Selective neuronal vulnerability in Parkinson disease. Nat. Rev. Neurosci. 18 (2):101–13. doi:10.1038/nrn.2016.178.
   PubMed Web of Science ®Google Scholar
• Swarnkar, S., P. Goswami, P. K. Kamat, I. K. Patro, S. Singh, and C. Nath. 2013. Rotenone-induced neurotoxicity in rat brain areas: A study on neuronal and neuronal supportive cells. Neuroscience 230:172–83. doi:10.1016/j.neuroscience.2012.10.034.
   PubMed Web of Science ®Google Scholar
• Tanner, C. M., F. Kamel, G. W. Ross, J. A. Hoppin, S. M. Goldman, M. Korell, C. Marras, G. S. Bhudhikanok, M. Kasten, A. R. Chade, et al. 2011. Rotenone, paraquat, and Parkinson’s disease. Environ. Health Perspect. 119 (6):866–72. doi:10.1289/ehp.1002839.
   PubMed Web of Science ®Google Scholar
• Tartaglione, A. M., A. Venerosi, and G. Calamandrei. 2016. Early-life toxic Insults and onset of sporadic neurodegenerative diseases-an Overview of experimental studies. Current Topics in Behav. Neurosci 29:231–64. doi:10.1007/7854_2015_416.
   PubMedGoogle Scholar
• Tay, T. L., O. Ronneberger, S. Ryu, R. Nitschke, and W. Driever. 2011. Comprehensive catecholaminergic projectome analysis reveals single-neuron integration of zebrafish ascending and descending dopaminergic systems. Nat. Commun. 2 (1):171. doi:10.1038/ncomms1171.
   PubMedGoogle Scholar
• Thirugnanam, T., and K. Santhakumar. 2022. Chemically induced models of Parkinson’s disease. Comp. Biochem. Physiol. C: Toxicol. Pharmacol 252:109213. doi:10.1016/j.cbpc.2021.109213.
   PubMed Web of Science ®Google Scholar
• Thirumalai, V., and H. T. Cline. 2008. Endogenous dopamine suppresses initiation of swimming in prefeeding zebrafish larvae. J. Neurophysiol. 100 (3):1635–48. doi:10.1152/jn.90568.2008.
   PubMed Web of Science ®Google Scholar
• Tierney, K. B. 2011. Behavioural assessments of neurotoxic effects and neurodegeneration in zebrafish. Biochi. Biophy. Acta (BBA) - Mol. Basis of Dis 1812 (3):381–89. doi:10.1016/j.bbadis.2010.10.011.
   PubMed Web of Science ®Google Scholar
• Üstündağ, F. D., I. Ünal, D. Cansız, U. V. Üstündağ, H. K. Subaşat, A. A. Alturfan, P. M. Tiber, and E. Emekli-Alturfan. 2020. 3-Pyridinylboronic acid normalizes the effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine exposure in zebrafish embryos. Drug Chem. Toxicol. 45 (2):947–54. doi:10.1080/01480545.2020.1795189.
   PubMed Web of Science ®Google Scholar
• Üstündağ, F. D., İ. Ünal, Ü. V. Üstündağ, D. Cansız, M. Beler, A. Karagöz, H. K. Subaşat, A. A. Alturfan, P. M. Tiber, and E. Emekli-Alturfan. 2022. 3-pyridinylboronic acid ameliorates rotenone-induced oxidative stress through nrf2 target genes in zebrafish embryos. Neurochem. Res. 47 (6):1553–64. doi:10.1007/s11064-022-03548-6.
   PubMed Web of Science ®Google Scholar
• Vaccari, C., R. Dib, H. Gomaa, L. C. Lopes, J. Lauro, and C. Vaccari. 2019. Paraquat and Parkinson’s disease: A systematic review and meta-analysis of observational studies. J. Toxicol. Environ. Health B 22 (5–6):172–202. doi:10.1080/10937404.2019.1659197.
   PubMed Web of Science ®Google Scholar
• Varešlija, D., K. F. Tipton, G. P. Davey, and A. G. McDonald. 2020. 6-Hydroxydopamine: A far from simple neurotoxin. J. Neural Transm. 172 (2):213–30. doi:10.1007/s00702-019-02133-6.
   Google Scholar
• Vaz, R. L., S. Sousa, D. Chapela, H. C. van der Linde, R. Willemsen, A. D. Correia, T. F. Outeiro, and N. D. Afonso. 2020. Identification of antiparkinsonian drugs in the 6-hydroxydopamine zebrafish model. Pharmacol. Biochem. Behav. 189:172828. doi:10.1016/j.pbb.2019.172828.
   PubMed Web of Science ®Google Scholar
• Vila, M., S. Vukosavic, V. Jackson-Lewis, M. Neystat, M. Jakowec, and S. Przedborski. 2000. α-synuclein up-regulation in substantia nigra dopaminergic neurons following administration of the parkinsonian toxin MPTP. J. Neurochem. 74 (2):721–29. doi:10.1046/j.1471-4159.2000.740721.x.
   PubMed Web of Science ®Google Scholar
• Vitoratos, A. G. 2014. Mode of action and genetic analysis of resistance to fluazinam in Ustilago maydis. J. Phytopathol 162 (11–12):737–46. ddoi:10.1111/jph.12254.
   Web of Science ®Google Scholar
• Wang, Y., L. Gao, J. Chen, Q. Li, L. Huo, Y. Wang, H. Wang, and J. Du. 2021. Pharmacological modulation of nrf2/ho-1 signaling pathway as a therapeutic target of Parkinson’s disease. Front Pharmacol. 12:1–35. doi:10.3389/fphar.2021.757161.
   Web of Science ®Google Scholar
• Wang, X. H., C. L. Souders, Y. H. Zhao, and C. J. Martyniuk. 2018a. Mitochondrial bioenergetics and locomotor activity are altered in zebrafish (Danio rerio) after exposure to the bipyridylium herbicide diquat. Toxicol. Lett. 283:13–20. doi:10.1016/j.toxlet.2017.10.022.
   PubMed Web of Science ®Google Scholar
• Wang, J., H. Xu, H. Jiang, X. Du, P. Sun, and J. Xie. 2012. Neurorescue effect of rosmarinic acid on 6-hydroxydopamine-lesioned nigral dopamine neurons in rat model of parkinson’s Disease. J. Mol. Neurosci 47 (1):113–19. doi:10.1007/s12031-011-9693-1.
   PubMed Web of Science ®Google Scholar
• Wang, Z., H. Zhao, Y. Xu, J. Zhao, Z. Song, Y. Bi, Y. Li, Lan X, Pan C, Foulkes NS, Zhang S. 2022. Early-life lead exposure induces long-term toxicity in the central nervous system: From zebrafish larvae to juveniles and adults. Sci. Total Environ. 804:150185. doi:10.1016/j.scitotenv.2021.150185.
   PubMed Web of Science ®Google Scholar
• Wang, X. H., S. S. Zheng, T. Huang, L. M. Su, Y. H. Zhao, C. L. Souders, and C. J. Martyniuk. 2018b. Fluazinam impairs oxidative phosphorylation and induces hyper/hypo-activity in a dose specific manner in zebrafish larvae. Chemosphere 210:633–44. doi:10.1016/j.chemosphere.2018.07.056.
   PubMed Web of Science ®Google Scholar
• Wichmann, T. 2019. Changing views of the pathophysiology of parkinsonism. Mov. Disorders 34 (8):1130–43. doi:10.1002/mds.27741.
   PubMed Web of Science ®Google Scholar
• Woodard, A., B. Barbery, R. Wilkinson, J. Strozyk, M. Milner, P. Doucette, J. Doran, K. Appleby, H. Atwill, W. E. Bell, et al. 2019. The role of neuronal nitric oxide and its pathways in the protection and recovery from neurotoxin-induced de novo hypokinetic motor behaviors in the embryonic zebrafish. Danio. rerio. 6 (1):25–42. doi:10.3934/Neuroscience.2019.1.25.
   Google Scholar
• Wu, W., H. Han, J. Liu, M. Tang, X. Wu, X. Cao, T. Zhao, Y. Lu, T. Niu, J. Chen, et al. 2021. Fucoxanthin prevents 6-OHDA-induced neurotoxicity by targeting keap1. Oxid. Med Cell Longev 2021:6688708. doi:10.1155/2021/6688708.
   PubMed Web of Science ®Google Scholar
• Xu, J., R. Casanave, and S. Guo. 2021. Larval zebrafish display dynamic learning of aversive stimuli in a constant visual surrounding. Learn. Memory 28 (7):228–38. doi:10.1101/lm.053425.121.
   PubMed Web of Science ®Google Scholar
• Xu, D. P., K. Zhang, Z. J. Zhang, Y. W. Sun, B. J. Guo, Y. Q. Wang, P. M. Hoi, Y. F. Han, and S. M. Y. Lee. 2014. A novel tetramethylpyrazine bis-nitrone (TN-2) protects against 6-hydroxyldopamine-induced neurotoxicity via modulation of the NF-κB and the PKCα/PI3-K/Akt pathways. Neurochem. Int. 78:76–85. doi:10.1016/j.neuint.2014.09.001.
   PubMed Web of Science ®Google Scholar
• Yao, L., S. X. Peng, Y. Xu, S. L. Lin, Y. H. Li, C. J. Liu, H. Zhao, L. F. Wang, and Y. Q. Shen. 2016. Unexpected neuroprotective effects of loganin on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity and cell death in zebrafish. J. Cell. Biochem. 118 (3):615–28. doi:10.1002/jcb.25749.
   PubMed Web of Science ®Google Scholar
• Yasuda, Y., T. Shimoda, K. Uno, N. Tateishi, S. Furuya, K. Yagi, K. Suzuki, and S. Fujita. 2008. The effects of MPTP on the activation of microglia/astrocytes and cytokine/chemokine levels in different mice strains. J. Neuroimmunol. 204 (1–2):43–51. doi:10.1016/j.jneuroim.2008.08.003.
   PubMed Web of Science ®Google Scholar
• Yee, A. G., S. M. Lee, M. R. Hunter, M. Glass, P. S. Freestone, and J. Lipski. 2014. Effects of the Parkinsonian toxin MPP+ on electrophysiological properties of nigral dopaminergic neurons. NeuroToxicology 45:1–11. doi:10.1016/j.neuro.2014.08.009.
   PubMed Web of Science ®Google Scholar
• Yu, H., J. Zhang, Y. Chen, J. Chen, Y. Qiu, Y. Zhao, H. Li, S. Xia, S. Chen, and J. Zhu. 2022. The adverse effects of fluxapyroxad on the neurodevelopment of zebrafish embryos. Chemosphere 307:135751. doi:10.1016/j.chemosphere.2022.135751.
   PubMed Web of Science ®Google Scholar
• Zeng, X. S., W. S. Geng, and J. J. Jia. 2018. Neurotoxin-induced animal models of Parkinson Disease: Pathogenic mechanism and assessment. ASN. Neuro 10:1759091418777438. doi:10.1177/1759091418777438.
   Web of Science ®Google Scholar
• Zhang, Z. J., L. C. V. Cheang, M. W. Wang, and S. M. Y. Lee. 2010. Quercetin exerts a neuroprotective effect through inhibition of the iNOS/NO system and pro-inflammation gene expression in PC12 cells and in zebrafish. Int. J. Mol. Med. 27 (2):195–203. doi:10.3892/ijmm.2010.571.
   PubMed Web of Science ®Google Scholar
• Zhang, Z. J., L. C. V. Cheang, M. W. Wang, G. H. Li, I. K. Chu, Z. X. Lin, and S. M. Y. Lee. 2012. Ethanolic extract of fructus Alpinia oxyphylla protects against 6-hydroxydopamine-induced damage of PC12 cells in vitro and dopaminergic neurons in zebrafish. Cell. Mol. Neurobiol. 32 (1):27–40. doi:10.1007/s10571-011-9731-0.
   PubMed Web of Science ®Google Scholar
• Zhang, J., V. A. Fitsanakis, G. Gu, D. Jing, M. Ao, V. Amarnath, and T. J. Montine. 2003. Manganese ethylene-bis-dithiocarbamate and selective dopaminergic neurodegeneration in rat: A link through mitochondrial dysfunction. J. Neurochem. 84 (2):336–46. doi:10.1046/j.1471-4159.2003.01525.x.
   PubMed Web of Science ®Google Scholar
• Zhang, C., C. Li, S. Chen, Z. Li, X. Jia, K. Wang, J. Bao, Y. Liang, X. Wang, M. Chen, et al. 2017. Berberine protects against 6-OHDA-induced neurotoxicity in PC12 cells and zebrafish through hormetic mechanisms involving PI3K/AKT/Bcl-2 and Nrf2/HO-1 pathways. Redox Biol. 11:1–11. doi:10.1016/j.redox.2016.10.019.
   PubMed Web of Science ®Google Scholar
• Zhang, C., C. Li, S. Chen, Z. Li, L. Ma, X. Jia, K. Wang, J. Bao, Y. Liang, M. Chen, et al. 2017. Hormetic effect of panaxatriol saponins confers neuroprotection in PC12 cells and zebrafish through PI3K/AKT/mTOR and AMPK/SIRT1/FOXO3 pathways. Sci. Rep., 7,(1):1–12. doi:https://doi.org/10.1038/srep41082
   PubMed Web of Science ®Google Scholar
• Zhang, L., Y. Y. Li, T. Chen, W. Xia, Y. Zhou, Y. J. Wan, Z. Q. Lv, G. Q. Li, and S. Q. Xu. 2011. Abnormal development of motor neurons in perfluorooctane sulphonate exposed zebrafish embryos. Ecotoxicology 20 (4):643–52. doi:10.1007/s10646-011-0604-6.
   PubMed Web of Science ®Google Scholar
• Zhang, D., S. Li, L. Hou, L. Jing, Z. Ruan, B. Peng, X. Zhang, J. S. Hong, J. Zhao, and Q. Wang. 2021. Microglial activation contributes to cognitive impairments in rotenone-induced mouse Parkinson’s disease model. J . Neuroinflammation 18 (1):4. doi:10.1186/s12974-020-02065-z.
   PubMed Web of Science ®Google Scholar
• Zhang, Z., G. Li, S. S. W. Szeto, C. M. Chong, Q. Quan, C. Huang, W. Cui, B. Guo, Y. Wang, Y. Han, et al. 2015a. Examining the neuroprotective effects of protocatechuic acid and chrysin on in vitro and in vivo models of Parkinson disease. Free Radic. Biol. Med. 84:331–43. doi:10.1016/j.freeradbiomed.2015.02.030.
   PubMed Web of Science ®Google Scholar
• Zhang, L. Q., F. Sa, C. M. Chong, Y. Wang, Z. Y. Zhou, R. C. C. Chang, S. W. Chan, P. M. Hoi, and S. M. Yuen Lee. 2015b. Schisantherin a protects against 6-OHDA-induced dopaminergic neuron damage in zebrafish and cytotoxicity in SH-SY5Y cells through the ROS/NO and AKT/GSK3β pathways. J. Ethnopharmacol. 170:8–15. doi:10.1016/j.jep.2015.04.040.
   PubMed Web of Science ®Google Scholar
• Zhang, J., B. Sun, J. Yang, Z. Chen Li, N. Zhang, H. Li, and L. Shen. 2022. Comparison of the effect of rotenone and 1‑methyl‑4‑phenyl‑1,2,3,6‑tetrahydropyridine on inducing chronic Parkinson’s disease in mouse models. Mol. Med. Rep. 25:91. doi:10.3892/mmr.2022.12607.
   PubMed Web of Science ®Google Scholar
• Zhang, J., M. Wang, Y. Zhao, Y. Zhang, Y. Gao, X. Zhang, and G. Yang. 2022. Alpha-lipoic acid improved motor function in MPTP-induced Parkinsonian mice by reducing neuroinflammation in the nigral and spinal cord. Neurosci. Lett. 781:136669. doi:10.1016/j.neulet.2022.136669.
   PubMed Web of Science ®Google Scholar
• Zhao, Y., Y. Han, Z. Wang, T. Chen, H. Qian, J. He, J. Li, B. Han, and T. Wang. 2020. Rosmarinic acid protects against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced dopaminergic neurotoxicity in zebrafish embryos. Toxicol. Vitro 65:1–10. doi:10.1016/j.tiv.2020.104823.
   Web of Science ®Google Scholar
• Zhong, H. J., J. J. Liu, C. M. Chong, L. Lu, M. Wang, D. S. H. Chan, P. W. H. Chan, S. M. Lee, D. L. Ma, and C. H. Leung. 2014. Discovery of a natural product-like iNOS inhibitor by molecular docking with potential neuroprotective effects in vivo. PLoS. One 9:e92905. doi:10.1371/journal.pone.0092905.
   PubMed Web of Science ®Google Scholar
• Zhou, Y., P. Li, A. Brantner, H. Wang, X. Shu, J. Yang, N. Si, L. Han, H. Zhao, and B. Bian. 2017. Chemical profiling analysis of Maca using UHPLC-ESI-Orbitrap MS coupled with UHPLC-ESI-QqQ MS and the neuroprotective study on its active ingredients. Sci. Rep. 7 (1):1–14. doi:10.1038/srep44660.
   PubMedGoogle Scholar
• Zhu, J., R. Xia, Z. Liu, J. Shen, X. Gong, Y. Hu, H. Chen, Y. Yu, W. Gao, C. Wang, et al. 2020. Fenvalerate triggers Parkinson-like symptom during zebrafish development through initiation of autophagy and p38 MAPK/mTOR signaling pathway. Chemosphere 243:125336. doi:10.1016/j.chemosphere.2019.125336.
   PubMed Web of Science ®Google Scholar
• Zis, P., R. Erro, C. C. Walton, A. Sauerbier, and K. R. Chaudhuri. 2015. The range and nature of non-motor symptoms in drug-naive Parkinson’s disease patients: A state-of-the-art systematic review. Npj Parkinson’s Dis. 1 (1):15013. doi:10.1038/npjparkd.2015.13.
   PubMedGoogle Scholar