Application of nanoformulations as a strategy to optimize chemotherapeutic treatment of glioblastoma: a systematic review

References

• ABTA. 2023. American Brain Tumor Association. Glioblastoma (GBM). Accessed Oct 12. https://www.abta.org/tumor_types/glioblastoma-gbm/.
   Google Scholar
• Ag Seleci, D., V. Maurer, F. Stahl, T. Scheper, and G. Garnweitner. 2019. “Rapid microfluidic preparation of niosomes for targeted drug delivery.” International Journal of Molecular Sciences 20 (19): 19. https://doi.org/10.3390/ijms20194696.
   Web of Science ®Google Scholar
• Agrawal, U., G. Chashoo, P. R. Sharma, A. Kumar, A. K. Saxena, and S. P. Vyas. 2015. “Tailored Polymer–Lipid Hybrid Nanoparticles for the Delivery of Drug Conjugate: Dual Strategy for Brain Targeting.” Colloids and Surfaces B, Biointerfaces 126: 414–425. https://doi.org/10.1016/j.colsurfb.2014.12.045.
   PubMed Web of Science ®Google Scholar
• Aigner, A., and D. Kogel. 2018. “Nanoparticle/siRNA-Based Therapy Strategies in Glioma: Which Nanoparticles, Which siRnas?” Nanomedicine 13 (1): 89–103. https://doi.org/10.2217/nnm-2017-0230.
   PubMed Web of Science ®Google Scholar
• Ashrafzadeh, M. S., A. Akbarzadeh, A. Heydarinasab, and M. Ardjmand. 2020. “In vivo glioblastoma therapy using targeted liposomal cisplatin.” International Journal of Nanomedicine 15: 7035–7049. https://doi.org/10.2147/ijn.s255902.
   PubMed Web of Science ®Google Scholar
• Badie, B., and J. M. Berlin. 2013. “The Future of CpG Immunotherapy in Cancer.” Immunotherapy 5 (1): 1–3. https://doi.org/10.2217/imt.12.148.
   PubMed Web of Science ®Google Scholar
• Bastiancich, C., J. Bianco, K. Vanvarenberg, B. Ucakar, N. Joudiou, B. Gallez, G. Bastiat, F. Lagarce, V. Préat, and F. Danhier. 2017. “Injectable Nanomedicine Hydrogel for Local Chemotherapy of Glioblastoma After Surgical Resection.” Journal of Controlled Release 264: 45–54. https://doi.org/10.1016/j.jconrel.2017.08.019.
   PubMed Web of Science ®Google Scholar
• Bastiancich, C., E. Bozzato, U. Luyten, F. Danhier, G. Bastiat, and V. Préat. 2019. “Drug Combination Using an Injectable Nanomedicine Hydrogel for Glioblastoma Treatment.” International Journal of Pharmaceutics 559: 220–227. https://doi.org/10.1016/j.ijpharm.2019.01.042.
   PubMed Web of Science ®Google Scholar
• Bastiancich, C., L. Lemaire, J. Bianco, F. Franconi, F. Danhier, V. Préat, G. Bastiat, and F. Lagarce. 2018. “Evaluation of lauroyl-gemcitabine-loaded hydrogel efficacy in glioblastoma rat models.” Nanomedicine 13 (16): 1999–2013. https://doi.org/10.2217/nnm-2018-0057.
   PubMed Web of Science ®Google Scholar
• Bastiancich, C., K. Vanvarenberg, B. Ucakar, M. Pitorre, G. Bastiat, F. Lagarce, V. Preát, and F. Danhier. 2016. “Lauroyl-Gemcitabine-Loaded Lipid Nanocapsule Hydrogel for the Treatment of Glioblastoma.” Journal of Controlled Release 225: 283–293. https://doi.org/10.1016/j.jconrel.2016.01.054.
   PubMed Web of Science ®Google Scholar
• Benezra, M., D. Hambardzumyan, O. Penate-Medina, D. R. Veach, N. Pillarsetty, P. Smith-Jones, E. Phillips, et al. 2012. “Fluorine-labeled dasatinib nanoformulations as targeted molecular imaging probes in a PDGFB-driven murine glioblastoma model.” Neoplasia 14 (12): 1132–1143. https://doi.org/10.1593/neo.121750.
   PubMed Web of Science ®Google Scholar
• Birngruber, T., R. Raml, W. Gladdines, C. Gatschelhofer, E. Gander, A. Ghosh, and F. Sinner. 2014. “Enhanced Doxorubicin Delivery to the Brain Administered Through Glutathione PEGylated Liposomal Doxorubicin (2B3-101) As Compared with Generic Caelyx,®/Doxil®—A Cerebral Open Flow Microperfusion Pilot Study.” Journal of Pharmaceutical Sciences 103 (7): 1945–1948. https://doi.org/10.1002/jps.23994.
   PubMed Web of Science ®Google Scholar
• Buzzelli, J. N., D. Ouaret, G. Brown, P. D. Allen, and R. J. Muschel. 2018. “Colorectal Cancer Liver Metastases Organoids Retain Characteristics of Original Tumor and Acquire Chemotherapy Resistance.” Stem Cell Research 27: 109–120. https://doi.org/10.1016/j.scr.2018.01.016.
   PubMed Web of Science ®Google Scholar
• Carpentier, A., P. Metellus, R. Ursu, S. Zohar, F. Lafitte, M. Barrie, Y. Meng, et al. 2010. “Intracerebral Administration of CpG Oligonucleotide for Patients with Recurrent Glioblastoma: A Phase II Study.” Neuro-Oncology 12 (4): 401–408. https://doi.org/10.1093/neuonc/nop047.
   PubMed Web of Science ®Google Scholar
• Chanphai, P., T. J. Thomas, and H. A. Tajmir-Riahi. 2019. “Design of functionalized folic acid–chitosan nanoparticles for delivery of tetracycline, doxorubicin, and tamoxifen.” Journal of Biomolecular Structure & Dynamics 37 (4): 1000–1006. https://doi.org/10.1080/07391102.2018.1445559.
   PubMed Web of Science ®Google Scholar
• Chen, H., and J. Wen. 2022. “Iron Oxide Nanoparticles Loaded with Paclitaxel Inhibits Glioblastoma by Enhancing Autophagy-Dependent Ferroptosis Pathway.” European Journal of Pharmacology 921: 174860. https://doi.org/10.1016/j.ejphar.2022.174860.
   PubMed Web of Science ®Google Scholar
• Chen, R., A. L. Cohen, and H. Colman. 2016. “Targeted Therapeutics in Patients with High-Grade Gliomas: Past, Present, and Future.” Current Treatment Options in Oncology 17 (8): 42. https://doi.org/10.1007/s11864-016-0418-0.
   PubMed Web of Science ®Google Scholar
• Chen, Y., J. Sun, Y. Huang, Y. Liu, L. Liang, D. Yang, and S. Li. 2019. “Targeted Codelivery of Doxorubicin and IL-36γ Expression Plasmid for an Optimal Chemo-Gene Combination Therapy Against Cancer Lung Metastasis.” Nanomedicine: Nanotechnology, Biology and Medicine 15 (1): 129–141. https://doi.org/10.1016/j.nano.2018.09.005.
   PubMed Web of Science ®Google Scholar
• Cox, A., D. Vinciguerra, F. Re, R. Dal Magro, S. Mura, M. Masserini, and J. Nicolas. 2019. “Protein-Functionalized Nanoparticles Derived from End-Functional Polymers and Polymer Prodrugs for Crossing the Blood-Brain Barrier.” European Journal of Pharmaceutics & Biopharmaceutics 142: 70–82. https://doi.org/10.1016/j.ejpb.2019.06.004.
   PubMed Web of Science ®Google Scholar
• Cutler, J. I., E. Auyeung, and C. A. Mirkin. 2012. “Spherical Nucleic Acids.” Journal of the American Chemical Society 134 (3): 1376–1391. https://doi.org/10.1021/ja209351u.
   PubMed Web of Science ®Google Scholar
• De Cristo Soares Alves, A., V. Lavayen, A. De Fraga Dias, F. A. Bruinsmann, J. N. Scholl, R. Cé, F. Visioli, et al. 2021. “EGFRvIII peptide nanocapsules and bevacizumab nanocapsules: A nose-to-brain multitarget approach against glioblastoma.” Nanomedicine 16 (20): 1775–1790. https://doi.org/10.2217/nnm-2021-0169.
   PubMed Web of Science ®Google Scholar
• Di Filippo, L. D., J. L. Duarte, J. H. Azambuja, R. I. Mancuso, M. T. Luiz, V. H. S. Araújo, and M. Chorilli. 2022. “Glioblastoma Multiforme Targeted Delivery of Docetaxel Using Bevacizumab-Modified Nanostructured Lipid Carriers Impair In Vitro Cell Growth and in vivo Tumor Progression.” International Journal of Pharmaceutics 618: 121682. https://doi.org/10.1016/j.ijpharm.2022.121682.
   PubMed Web of Science ®Google Scholar
• Dilnawaz, F., and S. K. Sahoo. 2013. “Enhanced accumulation of curcumin and temozolomide loaded magnetic nanoparticles executes profound cytotoxic effect in glioblastoma spheroid model.” European Journal of Pharmaceutics & Biopharmaceutics 85 (3): 452–462. https://doi.org/10.1016/j.ejpb.2013.07.013.
   PubMed Web of Science ®Google Scholar
• Emens, L. A., P. A. Ascierto, P. K. Darcy, S. Demaria, A. M. M. Eggermont, W. L. Redmond, and F. M. Marincola. 2017. “Cancer Immunotherapy: Opportunities and Challenges in the Rapidly Evolving Clinical Landscape.” European Journal of Cancer (Oxford, England: 1990) 81:116–129. https://doi.org/10.1016/j.ejca.2017.01.035.
   PubMed Web of Science ®Google Scholar
• Gaillard, P. J., C. C. Appeldoorn, R. Dorland, J. van Kregten, F. Manca, D. J. Vugts, O. van Tellingen, and G. Velasco. 2014. “Pharmacokinetics, Brain Delivery, and Efficacy in Brain Tumor-Bearing Mice of Glutathione PEGylated Liposomal Doxorubicin (2B3-101).” Public Library of Science ONE 9 (1): e82331. https://doi.org/10.1371/journal.pone.0082331.
   Google Scholar
• Ganipineni, L. P., B. Ucakar, N. Joudiou, J. Bianco, and V. Préat. 2018. “Magnetic Targeting of Paclitaxel-Loaded Poly(lactic-Co-Glycolic Acid)-Based Nanoparticles for the Treatment of Glioblastoma.” International Journal of Nanomedicine 13: 4509–4521. https://doi.org/10.2147/ijn.s165184.
   PubMed Web of Science ®Google Scholar
• Gao, H., S. Zhang, Z. Yang, S. Cao, X. Jiang, and Z. Pang. 2014. “In vitro and in vivo intracellular distribution and anti-glioblastoma effects of docetaxel-loaded nanoparticles functioned with IL-13 peptide.” International Journal of Pharmaceutics 466 (1–2): 8–17. https://doi.org/10.1016/j.ijpharm.2014.03.012.
   PubMed Web of Science ®Google Scholar
• Ghaferi, M., A. Raza, M. Koohi, W. Zahra, A. Akbarzadeh, H. EbrahimiShahmabadi, and S. E. Alavi. 2022. “Impact of PEGylated liposomal doxorubicin and carboplatin combination on glioblastoma.” Pharmaceutics 14 (10): 2183. https://doi.org/10.3390/pharmaceutics14102183.
   PubMed Web of Science ®Google Scholar
• Iwama, E., Y. Nakanishi, and I. Okamoto. 2018. “Combined Therapy with Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors for Non–Small Cell Lung Cancer.” Expert Review of Anticancer Therapy 18: 267–276. https://doi.org/10.1080/14737140.2018.1432356.
   PubMed Web of Science ®Google Scholar
• Jensen, S. A., E. S. Day, C. H. Ko, L. A. Hurley, J. P. Luciano, F. M. Kouri, and T. J. Merkel. 2013. “Spherical nucleic acid nanoparticle conjugates as an RNAi-based therapy for glioblastoma.” Science Translational Medicine 5 (209): 209ra152. https://doi.org/10.1126/scitranslmed.3006839.
   PubMed Web of Science ®Google Scholar
• Jiao, Y., H. Sun, Y. Jia, Y. Liu, Y. Gao, M. Xian, and C. Dong. 2019. “Functionalized fluorescent carbon nanoparticles for sensitively targeted of folate-receptor-positive cancer cells.” Microchemical Journal 146: 464–470. https://doi.org/10.1016/j.microc.2019.01.003.
   Web of Science ®Google Scholar
• Kadari, A., D. Pooja, R. H. Gora, S. Gudem, V. Kolapalli, H. Kulhari, and R. Sistla. 2018. “Design of multifunctional peptide collaborated and docetaxel loaded lipid nanoparticles for antiglioma therapy.” European Journal of Pharmaceutics & Biopharmaceutics 132: 168–179. https://doi.org/10.1016/j.ejpb.2018.09.012.
   PubMed Web of Science ®Google Scholar
• Kadhim, Z. A., G. M. Sulaiman, A. M. Al-Shammari, R. A. Khan, O. Al Rugaie, and H. A. Mohammed. 2022. “Oncolytic Newcastle Disease Virus Co-Delivered with Modified PLGA Nanoparticles Encapsulating Temozolomide Against Glioblastoma Cells: Developing an Effective Treatment Strategy.” Molecules 27 (18): 5757. https://doi.org/10.3390/molecules27185757.
   PubMed Web of Science ®Google Scholar
• Kadiyala, P., D. Li, F. M. Nuñez, D. Altshuler, R. Doherty, R. Kuai, M. Yu, et al. 2019. “High Density Lipoprotein-Mimicking Nanodiscs for Chemo-Immunotherapy Against Glioblastoma Multiforme.” Agricultural Science & Technology Nano 13: 1365–1384. https://doi.org/10.1021/acsnano.8b06842.
   Google Scholar
• Kievit, F. M., F. Y. Wang, C. Fang, H. Mok, K. Wang, J. R. Silber, R. G. Ellenbogen, and M. Zhang. 2011. “Doxorubicin Loaded Iron Oxide Nanoparticles Overcome Multidrug Resistance in Cancer in vitro.” Journal of Controlled Release 152 (1): 76–83. https://doi.org/10.1016/j.jconrel.2011.01.024.
   PubMed Web of Science ®Google Scholar
• Kim, S. S., A. Rait, E. Kim, J. Demarco, K. F. Pirollo, and E. H. Chang. 2015. “Encapsulation of Temozolomide in a Tumor-Targeting Nanocomplex Enhances Anti-Cancer Efficacy and Reduces Toxicity in a Mouse Model of Glioblastoma.” Cancer Letters 369 (1): 250–258. https://doi.org/10.1016/j.canlet.2015.08.022.
   PubMed Web of Science ®Google Scholar
• Koirala, N., D. Das, E. Fayazzadeh, S. Sen, A. Mcclain, J. E. Puskas, and G. Mclennan. 2019. “Folic acid conjugated polymeric drug delivery vehicle for targeted cancer detection in hepatocellular carcinoma.” Journal of Biomedical Materials Research Part A 107 (11): 2522–2535. https://doi.org/10.1002/jbm.a.36758.
   PubMed Web of Science ®Google Scholar
• Kumthekar, P., C. H. Ko, T. Paunesku, K. Dixit, A. M. Sonabend, O. Bloch, M. Tate, et al. 2021. “A First-In-Human Phase 0 Clinical Study of RNA Interference–Based Spherical Nucleic Acids in Patients with Recurrent Glioblastoma.” Science Translational Medicine 13 (584): 584. https://doi.org/10.1126/scitranslmed.abb3945.
   Web of Science ®Google Scholar
• Lam, F. C., S. W. Morton, J. Wyckoff, T. L. V. Han, M. K. Hwang, A. Maffa, and P. T. Hammond 2018. Enhanced Efficacy of Combined Temozolomide and Bromodomain Inhibitor Therapy for Gliomas Using Targeted Nanoparticles. Nature Communications. 9: 1991. https://doi.org/10.1016/j.bbcan.2012.12.004.
   PubMed Web of Science ®Google Scholar
• Lawrie, T. A., C. R. Hanna, E. Rogozińska, A. Kernohan, L. Vale, H. Bulbeck, U. M. Ali, and R. Grant. 2019. “Treatment of Newly Diagnosed Glioblastoma in the Elderly.” Cochrane Database of Systematic Reviews 3: CD013261. https://doi.org/10.1002/14651858.CD013261.
   Google Scholar
• Li, D., K. Yang, J. S. Li, X. Y. Ke, Y. Duan, R. Du, P. Song, et al. 2012. “Antitumor efficacy of a novel CLA-PTX microemulsion against brain tumors: in vitro and in vivo findings.” International Journal of Nanomedicine 7: 6105–6114. https://doi.org/10.2147/IJN.S38927.
   PubMed Web of Science ®Google Scholar
• Mahmoud, B. S., and C. McConville. 2021. “Development and Optimization of Irinotecan-Loaded Pcl Nanoparticles and Their Cytotoxicity Against Primary High-Grade Glioma Cells.” Pharmaceutics 13 (4): 541. https://doi.org/10.3390/pharmaceutics13040541.
   PubMed Web of Science ®Google Scholar
• Malik, I. A., N. Naz, N. Sheikh, S. Khan, F. Moriconi, M. Blaschke, and G. Ramadori. 2011. “Comparison of Changes in Gene Expression of Transferrin Receptor-1 and Other Iron-Regulatory Proteins in Rat Liver and Brain During Acute-Phase Response.” Cell and Tissue Research 344 (2): 299. https://doi.org/10.1007/s00441-011-1152-3.
   PubMed Web of Science ®Google Scholar
• Mehrabian, A., M. Mashreghi, S. Dadpour, A. Badiee, L. Arabi, S. Hoda Alavizadeh, S. Alia Moosavian, and M. Reza Jaafari. 2022. “Nanocarriers Call the Last Shot in the Treatment of Brain Cancers.” Technology in Cancer Research & Treatment 21: 15330338221080974. https://doi.org/10.1177/15330338221080974.
   Web of Science ®Google Scholar
• Mohamadi, N., S. M. Kazemi, M. Mohammadian, A. T. Milani, Y. Moradi, M. Yasemi, M. Ebrahimi Far, M. M. Tabrizi, H. E. Shahmabadi, and A. A. Khiyavi. 2017. “Toxicity of Cisplatin-Loaded Poly Butyl Cyanoacrylate Nanoparticles in a Brain Cancer Cell Line: Anionic Polymerization Results.” Asian Pacific Journal of Cancer Prevention: APJCP 18: 629–632. https://doi.org/10.22034/APJCP.2017.18.3.629.
   PubMedGoogle Scholar
• Moore, T. L., S. W. Grimes, R. L. Lewis, and F. Alexis. 2014. “Multilayered Polymer Coated Carbon Nanotubes to Deliver Dasatinib.” Molecular Pharmacology 11 (1): 276–282. https://doi.org/10.1021/mp400448w.
   PubMedGoogle Scholar
• Mosafer, J., M. Teymouri, K. Abnous, M. Tafaghodi, and M. Ramezani. 2017. “Study and Evaluation of Nucleolin-Targeted Delivery of Magnetic PLGA-PEG Nanospheres Loaded with Doxorubicin to C6 Glioma Cells Compared with Low Nucleolin-Expressing L929 Cells.” Materials Science and Engineering 72: 123–133. https://doi.org/10.1016/j.msec.2016.11.053.
   Google Scholar
• Mousavi, M., F. Koosha, and A. Neshastehriz. 2023. “Chemo-Radiation Therapy of U87-MG Glioblastoma Cells Using Spio@auNP-Cisplatin-Alginate Nanocomplex.” Heliyon 9 (3): e13847. https://doi.org/10.1016/j.heliyon.2023.e13847.
   PubMed Web of Science ®Google Scholar
• Mu, Q., M. Jeon, M. Hsiao, V. Patton, K. Wang, O. W. Press, and M. Zhang. 2015. “Stable and efficient paclitaxel nanoparticles for targeted glioblastoma therapy.” Advanced Healthcare Materials 4 (8): 1236–1245. https://doi.org/10.1002/adhm.201500034.
   PubMed Web of Science ®Google Scholar
• Naidu, P. S., N. Gavriel, C. G. Gray, C. A. Bartlett, L. M. Toomey, J. Kretzmann, and D. Ho. 2019. “Elucidating the Inability of Functionalized Nanoparticles to Cross the Blood–Brain Barrier and Target Specific Cells in vivo.” ACS Applied Materials and Interfaces 11 (25): 22085–22095. https://doi.org/10.1021/acsami.9b01356.
   PubMed Web of Science ®Google Scholar
• NCI – National Cancer Institute. 2023. Clinical Trials – Irinotecan Pegol. EUA. Accessed October 12. https://www.cancer.gov/publications/dictionaries/cancer-drug/def/etirinotecan-pegol?redirect=true.
   Google Scholar
• NEKTAR. 2022. Nektar Therapeutics. Ozeald (NKTR-102). Poster publication. https://www.nektar.com/science/scientific-posters-and-presentations.
   Google Scholar
• NLMa - National Library of Medicine. 2023. ClinicalTrials.Gov. Pegylated Liposomal Doxorubicine and Prolonged Temozolomide in Addition to Radiotherapy in Newly Diagnosed Glioblastoma (ID NCT00944801). University of Regensburg. https://clinicaltrials.gov/ct2/show/NCT00944801?term=liposome&cond=glioma&draw=1&rank=7.
   Google Scholar
• NLMb - National Library of Medicine. 2023. ClinicalTrials.Gov. A Study to Evaluate the Safety, Tolerability and Immunogenicity of EGFR(V)-EDV-Dox in Subjects with Recurrent Glioblastoma Multiforme (GBM) (CerebralEDV) (ID NCT02766699). Engeneic Pty Limited https://clinicaltrials.gov/ct2/show/NCT02766699?term=liposome&cond=glioma&draw=2&rank=14.
   Google Scholar
• Patel, N. R., B. S. Pattni, A. H. Abouzeid, and V. P. Torchilin. 2013. “Nanopreparations to overcome multidrug resistance in cancer.” Advanced Drug Delivery Reviews 65 (13–14): 1748–1762. https://doi.org/10.1016/j.addr.2013.08.004.
   PubMed Web of Science ®Google Scholar
• Perego, P., G. Hempel, S. Linder, T. D. Bradshaw, A. K. Larsen, G. J. Peters, R. M. Phillips, et al. 2018. “Estudos de farmacologia celular de agentes anticâncer: recomendações do grupo EORTC-PAMM.” Cancer Chemotherapy and Pharmacology 81 (3): 427–441. https://doi.org/10.1007/s00280-017-3502-7.
   PubMed Web of Science ®Google Scholar
• Pereira, N. R. C., R. A. Loiola, S. F. Rodrigues, C. P. De Oliveira, S. L. Büttenbender, S. S. Guterres, A. R. Pohlmann, and S. H. Farsky. 2018. “Mechanisms of the Effectiveness of poly(ε-Caprolactone) Lipid-Core Nanocapsules Loaded with Methotrexate on Glioblastoma Multiforme Treatment.” International Journal of Nanomedicine 13: 4563–4573. https://doi.org/10.2147/IJN.S168400.
   PubMed Web of Science ®Google Scholar
• Renziehausen, A., A. Tsiailanis, R. Perryman, E. Stylos, C. Chatzigiannis, K. O’Neill, T. Crook, A. G. Tzakos, and N. Syed. 2019. “Encapsulation of Temozolomide in a Calixarene Nanocapsule Improves Its Stability and Enhances Its Therapeutic Efficacy Against Glioblastoma.” Molecular Cancer Therapeutics 18 (9): 1497–1505. https://doi.org/10.1158/1535-7163.MCT-18-1250.
   PubMed Web of Science ®Google Scholar
• Reyes-Reyes, E. M., F. R. Šalipur, M. Shams, M. K. Forsthoefel, and P. J. Bates. 2015. “Mechanistic Studies of Anticancer Aptamer AS1411 Reveal a Novel Role for Nucleolin in Regulating Rac1 Activation.” Molecular Oncology 9 (7): 1392–1405. https://doi.org/10.1016/j.molonc.2015.03.012.
   PubMed Web of Science ®Google Scholar
• Ruan, C., L. Liu, Y. Lu, Y. Zhang, X. He, X. Chen, Y. Zhang, et al. 2018. “Substance P-Modified Human Serum Albumin Nanoparticles Loaded with Paclitaxel for Targeted Therapy of Glioma.” Acta pharmaceutica Sinica B 8 (1): 85–96. https://doi.org/10.1016/j.apsb.2017.09.008.
   PubMed Web of Science ®Google Scholar
• Ruoslahti, E. 2017. “Tumor penetrating peptides for improved drug delivery.” Advanced Drug Delivery Reviews 110: 3–12. https://doi.org/10.1016/j.addr.2016.03.008.
   PubMed Web of Science ®Google Scholar
• Sagnella, S. M., L. Yang, G. E. Stubbs, E. Boslem, E. Martino-Echarri, K. Smolarczyk, S. L. Pattison, et al. 2020. “Cyto-Immuno-Therapy for Cancer: A Pathway Elicited by Tumor-Targeted, Cytotoxic Drug-Packaged Bacterially Derived Nanocells.” Cancer Cell 37 (3): 354–370.e7. https://doi.org/10.1016/j.ccell.2020.02.001.
   PubMed Web of Science ®Google Scholar
• Salazar, A., V. Pérez-De La Cruz, E. Muñoz-Sandoval, V. Chavarria, M. L. García Morales, A. Espinosa-Bonilla, J. Sotelo, A. Jiménez-Anguiano, and B. Pineda. 2021. “Potential use of nitrogen-doped carbon nanotube sponges as payload carriers against malignant glioma.” Nanomaterials (Basel) 11 (5): 1244. https://doi.org/10.3390/nano11051244.
   PubMedGoogle Scholar
• Sarisozen, C., S. Dhokai, E. G. Tsikudo, E. Luther, I. M. Rachman, and V. P. Torchilin. 2016. “Nanomedicine Based Curcumin and Doxorubicin Combination Treatment of Glioblastoma with scFv-Targeted Micelles: In vitro Evaluation on 2D and 3D Tumor Models.” European Journal of Pharmaceutics & Biopharmaceutics 108: 54–67. https://doi.org/10.1016/j.ejpb.2016.08.013.
   PubMed Web of Science ®Google Scholar
• Schmitt, R. R., S. D. Mahajan, A. Pliss, and P. N. Prasad. 2022. “Small Molecule Based EGFR Targeting of Biodegradable Nanoparticles Containing Temozolomide and Cy5 Dye for Greatly Enhanced Image-Guided Glioblastoma Therapy.” Nanomedicine: Nanotechnology, Biology and Medicine 41: 102513. https://doi.org/10.1016/j.nano.2021.102513.
   PubMed Web of Science ®Google Scholar
• Scorilas, A., L. Kyriakopoulou, G. M. Yousef, L. K. Ashworth, A. Kwamie, and E. P. Diamandis. 2001. “Molecular Cloning, Physical Mapping, and Expression Analysis of a Novel Gene, BCL2L12, Encoding a Proline-Rich Protein with a Highly Conserved BH2 Domain of the Bcl-2 Family.” Genomics 72 (2): 217–221. https://doi.org/10.1006/geno.2000.6455.
   PubMed Web of Science ®Google Scholar
• Sharma, A. K., L. Gupta, H. Sahu, A. Qayum, S. K. Singh, K. T. Nakhate, and A. Gupta. 2018. “Chitosan Engineered PAMAM Dendrimers As Nanoconstructs for the Enhanced Anti-Cancer Potential and Improved in vivo Brain Pharmacokinetics of Temozolomide.” Pharmaceutical Research 35 (1): 9. https://doi.org/10.1007/s11095-017-2324-y.
   PubMed Web of Science ®Google Scholar
• Shevtsov, M., S. Stangl, B. Nikolaev, S. Edmond, L. Yakovleva, Y. Marchenko, and G. Multhoff. 2018. “P04. 01 Synergistic Antitumor Effects of a Combined Therapy Consisting of Immune Checkpoint Inhibitors and Tumor-Targeting Nanoparticles in Glioblastoma.” Neuro-Oncol 20 (suppl_3): iii277–iii278. https://doi.org/10.1093/neuonc/noy139.235.
   Google Scholar
• Shi, H., S. Sun, H. Xu, Z. Zhao, Z. Han, J. Jia, D. Wu, J. Lu, H. Liu, and R. Yu. 2020. “Combined Delivery of Temozolomide and siPlk1 Using Targeted Nanoparticles to Enhance Temozolomide Sensitivity in Glioma.” International Journal of Nanomedicine 15: 3347–3362. https://doi.org/10.2147/ijn.s243878.
   PubMed Web of Science ®Google Scholar
• Shi, K., J. Zhou, Q. Zhang, H. Gao, Y. Liu, T. Zong, and Q. He. 2015. “Arginine-glycine-aspartic acid-modified lipid-polymer hybrid nanoparticles for docetaxel delivery in glioblastoma multiforme.” Journal of Biomedical Nanotechnology 11 (3): 382–391. https://doi.org/10.1166/jbn.2015.1965.
   PubMed Web of Science ®Google Scholar
• Singh, P. K., A. K. Srivastava, A. Dev, B. Kaundal, S. R. Choudhury, and S. Karmakar. 2018. 1, 3β-Glucan anchored, paclitaxel loaded chitosan nanocarrier endows enhanced hemocompatibility with efficient anti-glioblastoma stem cells therapy. Carbohydrate Polymers 180 (1): 365–375. https://doi.org/10.1016/j.carbpol.2017.10.030
   PubMed Web of Science ®Google Scholar
• Singh, R., Z. Fazal, A. K. Corbet, E. Bikorimana, J. C. Rodriguez, E. M. Khan, and M. J. Spinella. 2019. “Epigenetic Remodeling Through Downregulation of Polycomb Repressive Complex 2 Mediates Chemotherapy Resistance in Testicular Germ Cell Tumors.” Cancers 11 (6): 796. https://doi.org/10.3390/cancers11060796.
   PubMed Web of Science ®Google Scholar
• Steffens, L., A. M. Morás, P. R. Arantes, K. Masterson, Z. Cao, M. Nugent, and D. J. Moura. 2020. “Electrospun PVA-Dacarbazine nanofibers as a novel nano brain-implant for treatment of glioblastoma: in silico and in vitro characterization.” European Journal of Pharmaceutical Sciences 143: 105183. https://doi.org/10.1016/j.ejps.2019.105183.
   PubMed Web of Science ®Google Scholar
• Stegh, A. H., H. Kim, R. M. Bachoo, K. L. Forloney, J. Zhang, H. Schulze, and L. Chin. 2007. “Bcl2L12 inhibits post-mitochondrial apoptosis signaling in glioblastoma.” Genes & Development 21 (1): 98–111. https://doi.org/10.1101/gad.1480007.
   PubMed Web of Science ®Google Scholar
• Sun, T., H. Wu, Y. Li, Y. Huang, L. Yao, X. Chen, X. Han, Y. Zhou, and Z. Du. 2017. “Targeting Transferrin Receptor Delivery of Temozolomide for a Potential Glioma Stem Cell-Mediated Therapy.” Oncotarget 8 (43): 74451–74465. https://doi.org/10.18632/oncotarget.20165.
   PubMedGoogle Scholar
• Szablewski, L. 2013. “Expression of Glucose Transporters in Cancers.” Biochimica et biophysica acta 1835 (2): 164–169. https://doi.org/10.1016/j.bbcan.2012.12.004.
   PubMed Web of Science ®Google Scholar
• Tao, Y., M. Ning, and H. Dou. 2013. “A Novel Therapeutic System for Malignant Glioma: Nanoformulation, Pharmacokinetic, and Anticancer Properties of Cell-Nano-Drug Delivery.” Nanomedicine: Nanotechnology, Biology and Medicine 9 (2): 222–232. https://doi.org/10.1016/j.nano.2012.10.006.
   PubMed Web of Science ®Google Scholar
• Thakur, A., C. Faujdar, R. Sharma, S. Sharma, B. Malik, K. Nepali, and J. P. Liou. 2022. “Glioblastoma: Current Status, Emerging Targets, and Recent Advances.” Journal of Medicinal Chemistry 65 (13): 8596–8685. https://doi.org/10.1021/acs.jmedchem.1c01946.
   PubMed Web of Science ®Google Scholar
• Torchilin, V. P. 2007. “Targeted Pharmaceutical Nanocarriers for Cancer Therapy and Imaging.” The AAPS Journal 9 (2): E128–E147. https://doi.org/10.1208/aapsj0902015.
   PubMed Web of Science ®Google Scholar
• Varan, C., and E. Bilensoy. 2017. “Cationic PEGylated Polycaprolactone Nanoparticles Carrying Post-Operation Docetaxel for Glioma Treatment.” Beilstein Journal of Nanotechnology 8: 1446–1456. https://doi.org/10.3762/bjnano.8.144.
   PubMed Web of Science ®Google Scholar
• Verreault, M., D. Strutt, D. Masin, M. Anantha, A. Yung, P. Kozlowski, D. Waterhouse, M. B. Bally, and D. T. Yapp. 2011. “Vascular Normalization in Orthotopic Glioblastoma Following Intravenous Treatment with Lipid-Based Nanoparticulate Formulations of Irinotecan (Irinophore C™), Doxorubicin (Caelyx®) or Vincristine.” BMC Cancer 11 (1): 124. https://doi.org/10.1186/1471-2407-11-124.
   PubMedGoogle Scholar
• Wan, Z., C. Li, J. Gu, J. Qian, J. Zhu, J. Wang, Y. Li, J. Jiang, H. Chen, and C. Luo. 2021. “Accurately Controlled Delivery of Temozolomide by Biocompatible UiO-66-NH2 Through Ultrasound to Enhance the Antitumor Efficacy and Attenuate the Toxicity for Treatment of Malignant Glioma.” International Journal of Nanomedicine 16: 6905–6922. https://doi.org/10.2147/ijn.s330187.
   PubMedGoogle Scholar
• Wang, L., Y. Hu, Y. Hao, L. Li, C. Zheng, H. Zhao, and Y. Zhang. 2018a. “Tumor-Targeting Core-Shell Structured Nanoparticles for Drug Procedural Controlled Release and Cancer Sonodynamic Combined Therapy.” Journal of Controlled Release: Official Journal of the Controlled Release Society 286: 74–84. https://doi.org/10.1016/j.jconrel.2018.07.028.
   PubMed Web of Science ®Google Scholar
• Wang, X., J. Gao, X. Ouyang, J. Wang, X. Sun, and Y. Lv. 2018b. “Mesenchymal Stem Cells Loaded with Paclitaxel-Poly(lactic-Co-Glycolic Acid) Nanoparticles for Glioma-Targeting Therapy.” International Journal of Nanomedicine 13: 5231–5248. https://doi.org/10.2147/ijn.s167142.
   PubMed Web of Science ®Google Scholar
• Wang, L., X. Wang, L. Shen, M. Alrobaian, S. K. Panda, H. A. Almasmoum, M. M. Ghaith, et al. 2021. “Paclitaxel and Naringenin-Loaded Solid Lipid Nanoparticles Surface Modified with Cyclic Peptides with Improved Tumor Targeting Ability in Glioblastoma Multiforme.” Biomedicine & Pharmacotherapy 138: 111461. https://doi.org/10.1016/j.biopha.2021.111461.
   PubMed Web of Science ®Google Scholar
• Wang, X., C. Wu, S. Liu, and D. Peng. 2022. “Combinatorial Therapeutic Strategies for Enhanced Delivery of Therapeutics to Brain Cancer Cells Through Nanocarriers: Current Trends and Future Perspectives.” Drug Delivery 29 (1): 1370–1383. https://doi.org/10.1080/10717544.2022.2069881.
   PubMed Web of Science ®Google Scholar
• Wen, L., Y. Tan, S. Dai, Y. Zhu, T. Meng, X. Yang, Y. Liu, X. Liu, H. Yuan, and F. Hu. 2017. “VEGF-Mediated Tight Junctions Pathological Fenestration Enhances Doxorubicin-Loaded Glycolipid-Like Nanoparticles Traversing BBB for Glioblastoma-Targeting Therapy.” Drug Delivery 24 (1): 1843–1855. https://doi.org/10.1080/10717544.2017.1386731.
   PubMed Web of Science ®Google Scholar
• WHO. World Health Organization. 2020. GLOBOCAN 2020 – CANCER TODAY. França. Accessed October 12. https://gco.iarc.fr/today/fact-sheets-cancers.
   Google Scholar
• Winograd, E., I. Germano, P. Wen, J. J. Olson, and D. R. Ormond. 2022. “Congress of Neurological Surgeons Systematic Review and Evidence-Based Guidelines Update on the Role of Targeted Therapies and Immunotherapies in the Management of Progressive Glioblastoma.” Journal of Neuro-Oncology 158 (2): 265–321. https://doi.org/10.1007/s11060-021-03876-7.
   PubMed Web of Science ®Google Scholar
• Xu, H., Y. Zhang, L. Li, Y. Ren, F. Qian, L. Wang, H. Ma, A. Quan, H. Liu, and R. Yu. 2023. “The Nanoprodrug of Polytemozolomide Combines with MGMT SiRNA to Enhance the Effect of Temozolomide in Glioma.” Drug Delivery 30 (1): 1–13. https://doi.org/10.1080/10717544.2022.2152911.
   PubMed Web of Science ®Google Scholar