4,131
Views
1
CrossRef citations to date
0
Altmetric
Article

Comparative Study Among Ephedrine, Norepinephrine and Phenylephrine Infusions to Prevent Spinal Hypotension During Cesarean Section. A Randomized Controlled Double-Blind Study

ORCID Icon, & ORCID Icon
Pages 295-301 | Received 29 Mar 2021, Accepted 26 May 2021, Published online: 12 Jun 2021

References

  • Gandhi KA, Jain K. Management of anaesthesia for elective, low-risk (Category 4) caesarean section. Indian J Anaesth. 2018;62(9):667.
  • Ngan Kee WD. Prevention of maternal hypotension after regional anaesthesia for caesarean section. Curr Opin Anesthesiol. 2010;23(3):304–309.
  • Klöhr S, Roth R, Hofmann T, et al. Definitions of hypotension after spinal anaesthesia for caesarean section: literature search and application to parturients. Acta Anaesthesiol Scand. 2010;54(8):909–921.
  • Salinas FV, Sueda LA, Liu SS, et al. Physiology of spinal anaesthesia and practical suggestions for successful spinal anaesthesia. Best Pract Res Clin Anaesthesiol. 2003;17(3):289–303.
  • Neal JM. Hypotension and bradycardia during spinal anesthesia: significance, prevention, and treatment. Tech Reg Anesth Pain Manage. 2000;4(4):148–154.
  • Macarthur A, Riley ET. Obstetric anesthesia controversies: vasopressor choice for postspinal hypotension during cesarean delivery. Int Anesthesiol Clin. 2007;45(1):115–132.
  • Okudaira S, Suzuki S. Influence of spinal hypotension on fetal oxidative status during elective cesarean section in uncomplicated pregnancies. Arch Gynecol Obstet. 2005;271(4):292–295.
  • Maayan-Metzger A, Schushan-Eisen I, Todris L, et al. Maternal hypotension during elective cesarean section and short-term neonatal outcome. Am J Obstet Gynecol. 2010;202(1):56. e1-5.
  • Vercauteren M, Hoffmann V, Coppejans H, et al. Hydroxyethylstarch compared with modified gelatin as volume preload before spinal anaesthesia for caesarean section. Br J Anaesth. 1996;76(5):731–733.
  • Ben-David B, Miller G, Gavriel R, et al. Low-dose bupivacaine-fentanyl spinal anesthesia for cesarean delivery. Reg Anesth Pain Med. 2000;25(3):235–239.
  • Ngan Kee W, Khaw K, Lau T, et al. Randomised double-blinded comparison of phenylephrine vs ephedrine for maintaining blood pressure during spinal anaesthesia for non-elective caesarean section. Anaesthesia. 2008;63(12):1319–1326.
  • Wang X, Shen X, Liu S, et al. The efficacy and safety of norepinephrine and its feasibility as a replacement for phenylephrine to manage maternal hypotension during elective cesarean delivery under spinal anesthesia. BioMed Res Int. 2018;2018.
  • Moslemi F, Rasooli S. Comparison of prophylactic infusion of phenylephrine with ephedrine for prevention of hypotension in elective cesarean section under spinal anesthesi: a randomized clinical trial. Iran J Med Sci. 2015;40(1):19.
  • Saravanan S, Kocarev M, Wilson R, et al. Equivalent dose of ephedrine and phenylephrine in the prevention of post-spinal hypotension in caesarean section. Br J Anaesth. 2006;96(1):95–99.
  • Stewart A, Fernando R, McDonald S, et al. The dose-dependent effects of Phenylephrine for elective cesarean delivery under spinal anesthesia. Anaesth Analg. 2010;111(5):1230–1237.
  • Persson M, Razaz N, Tedroff K, et al. Five and 10 minute apgar scores and risks of cerebral palsy and epilepsy: population based cohort study in Sweden. BMJ. 2018;360:k207.
  • Feng K, Wang X, Feng X, et al. Effects of continuous infusion of phenylephrine vs. norepinephrine on parturients and fetuses under LiDCOrapid monitoring: a randomized, double-blind, placebo-controlled study. BMC Anesthesiol. 2020;20(1):229.
  • Das S, Mukhopadhyay S, Mandal M, et al. A comparative study of infusions of phenylephrine, ephedrine and phenylephrine plus ephedrine on maternal haemodynamics in elective caesarean section. Indian J Anaesth. 2011;55(6):578.
  • Sharwood-Smith G, Drummond G. Hypotension in obstetric spinal anaesthesia: a lesson from pre-eclampsia. Br J Anaesth. 2009;102(3):291–294.
  • Dyer RA, Reed AR, Van Dyk D, et al. Hemodynamic effects of ephedrine, phenylephrine, and the coadministration of phenylephrine with oxytocin during spinal anesthesia for elective cesarean delivery. Anesthesiol. 2009;111(4):753–765.
  • Lee A, Kee WDN, Gin T. A quantitative, systematic review of randomized controlled trials of ephedrine versus phenylephrine for the management of hypotension during spinal anesthesia for cesarean delivery. Anesth Analg. 2002;94(4):920–926.
  • Lee A, Kee WDN, Gin T. A dose-response meta-analysis of prophylactic intravenous ephedrine for the prevention of hypotension during spinal anesthesia for elective cesarean delivery. Anesth Analg. 2004;98(2):483–490.
  • Kee WDN, Lee SW, Ng FF, et al. Randomized double-blinded comparison of norepinephrine and phenylephrine for maintenance of blood pressure during spinal anesthesia for cesarean delivery. Anesthesiol. 2015;122(4):736–745.
  • Kee WDN. Prevention of maternal hypotension after regional anaesthesia for caesarean section. Curr Opin Anesthesiol. 2010;23(3):304–309.
  • Kee WDN, Khaw KS, Tan PE, et al. Placental transfer and fetal metabolic effects of phenylephrine and ephedrine during spinal anesthesia for cesarean delivery. Anesthesiol. 2009;111(3):506–512.
  • Mercier FJ, Riley ET, Frederickson WL, et al. Phenylephrine added to prophylactic ephedrine infusion during spinal anesthesia for elective cesarean section. Anesthesiol. 2001;95(3):668–674.
  • Jl A, Jl H, Agarkar M, et al. Practice guidelines for obstetric anesthesia: an updated report by the American society of anesthesiologists task force on obstetric anesthesia and the society for obstetric anesthesia and perinatology. Anesthesiol. 2016;124(2):270–300.
  • Loubert C. Fluid and vasopressor management for cesarean delivery under spinal anesthesia: continuing professional development. Can J Anesth. 2012;59(6):604–619.
  • Habib AS. A review of the impact of phenylephrine administration on maternal hemodynamics and maternal and neonatal outcomes in women undergoing cesarean delivery under spinal anesthesia. Anesth Analg. 2012;114(2):377–390.
  • Puolakka J, Kauppila A, Tuimala R, et al. The effect of parturition on umbilical blood plasma levels of norepinephrine. Obstet Gynecol. 1983;61(1):19–21.
  • Arago FF, Arago PW, Martins CA, et al. Comparison of metaraminol, phenylephrine and ephedrine in prophylaxis and treatment of hypotension in cesarean section under spinal anesthesia. Rev Bras  Anestesiol. 2014;64(5):299–306.
  • Veeser M, Hofmann T, Roth R, et al. Vasopressors for the management of hypotension after spinal anesthesia for elective caesarean section. Systematic review and cumulative meta-analysis. Acta Anaesthesiol Scand. 2012;56(7):810–816.
  • Cooper DW, Carpenter M, Mowbray P, et al. Fetal and maternal effects of phenylephrine and ephedrine during spinal anesthesia for cesarean delivery. Anesthesiol. 2002;97(6):1582–1590.