Resistance to 5-Fluorouracil and 5-Fluoro;-2’-deoxyuridine Mechanisms and Clinical Implications

A. SobreroIstituto Nazionale per la Ricerca sul Cancro, Viale Benedetto XV, 10 - 16132Genova, Italy

C. AscheleIstituto Nazionale per la Ricerca sul Cancro, Viale Benedetto XV, 10 - 16132Genova, Italy

A. GuglielmiIstituto Nazionale per la Ricerca sul Cancro, Viale Benedetto XV, 10 - 16132Genova, Italy

M.T. NobileIstituto Nazionale per la Ricerca sul Cancro, Viale Benedetto XV, 10 - 16132Genova, Italy

R. RossoIstituto Nazionale per la Ricerca sul Cancro, Viale Benedetto XV, 10 - 16132Genova, Italy

References

Erlichman C, Fine S, Wong A, Elhakeim T. A randomized trial of fluorouracil and folinic acid in patients with metastatic colorectal carcinoma. J Clin Oncol. 1988; 6: 469–475.
Google Scholar
Petrelli N, Herrera L, Rustum Y, et al. A prospective randomized trial of 5-fluorouracil versus 5-fluorouracil and high dose leucovorin versus 5-fluorouracil and methotrexate in previously untreated patients with advanced colorectal cancer. J Clin Oncol. 1987; 5: 1559–1565.
Google Scholar
Doroshow JH, Bertrand M, Molthauf P et al. Prospective randomized trial comparing 5-FU vs 5-FU and HD folinic acid for treatment of advanced colorectal cancer. ASCO 1987; 6: 374.
Google Scholar
Nobile MT, Vidilli MG, Sobrero A, et al. 5-FU alone or combined with HD folinic acid in advanced colorectal cancer patients: a randomized trial. ASCO 1988; 7: 97.
Google Scholar
Moran R. Leucovorin enhancement of the effects of the fluoropyrimidines on thymidylate synthase. Cancer 1989; 63: 1008–1012.
Google Scholar

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Resistance to 5-Fluorouracil and 5-Fluoro;-2’-deoxyuridine Mechanisms and Clinical Implications

References

Information for

Open access

Opportunities

Help and information

Your download is now in progress and you may close this window

Login or register to access this feature

Resistance to 5-Fluorouracil and 5-Fluoro;-2’-deoxyuridine Mechanisms and Clinical Implications

References

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date