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Journal of Chemotherapy Volume 2, 1990 - Issue 5
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Original Articles

Double-Blind Randomized Trial of Lorazepam versus Placebo with Methylprednisolone for Control of Emesis Due to Non-Cisplatin Containing Chemotherapy

E. CamporaDepartment of Medical Oncology, Istituto Nazionale per la Ricerca sul Cancro, Viale Benedetto XV, 10, 16132Genova, Italy.
,
E. BaldiniDepartment of Medical Oncology, Istituto Nazionale per la Ricerca sul Cancro, Viale Benedetto XV, 10, 16132Genova, Italy.
,
A. RubagottiDepartment of Medical Oncology, Istituto Nazionale per la Ricerca sul Cancro, Viale Benedetto XV, 10, 16132Genova, Italy.
,
S. ChiaraDepartment of Medical Oncology, Istituto Nazionale per la Ricerca sul Cancro, Viale Benedetto XV, 10, 16132Genova, Italy.
,
P. BruzziUnit of Clinical Epidemiology and Trials, Istituto Nazionale per la Ricerca sul Cancro, Viale Benedetto XV, 10, 16132Genova, Italy.
,
M.R. SertoliDepartment of Medical Oncology, Istituto Nazionale per la Ricerca sul Cancro, Viale Benedetto XV, 10, 16132Genova, Italy.
&
R. Rosso
 show all
Pages 336-339 | Published online: 14 Jul 2016

References

  • Wilcox PM, Petting JH, Nettesheim KM et al. Anticipatory vomiting in women receiving cyclophosphamide, meth otrexate and 5-fluorouracil (CMF) adjuvant chemotherapy for breast carcinoma. Cancer Treat Rep 1982; 66: 1601–1604.
  • David M, Durand M, Chauvergne J et al. Cyclophosphamide, methotrexate and 5-FU (CMF) induced nausea and vomiting: a controlled study with high dose metoclopramide. Cancer Treat Rep 1984; 68: 921–922.
  • Chiara S, Campora E, Lionetto R et al. Methylprednisolone for the control of CMF-induced emesis. Am J Clin Oncol 1987; 10(3): 264–267.
  • Roila F, Basurto C, Minotti V et al. Methylprednisolone versus metoclopramide for prevention of nausea and vomiting in breast cancer patients treated with intravenous cyclophosphamide, methotrexate and 5-fluorouracil: a double blind randomized study. Oncology 1988; 45: 346–349.
  • Gez E, Sulkes A, Ochayon L et al. Methylprednisolone versus metoclopramide as antiemetic treatment in patients receiving adjuvant cyclophosphamide, methotrexate, 5-fluorouracil (CMF) chemotherapy: a randomized crossover blind study. J Chemother 1989; 6: 365–368.
  • Kris MG, Gralla RJ, Tyson LB et al. Improved control of cisplatin-induced emesis with high dose metoclopramide and combinations of metoclopramide, dexamethasone and diphenhydramine: Results of consecutive trials in 255 patients. Cnacer 1985; 527–534.
  • Sledge GW, Loehrer PJ, Roth BJ et al. Cisplatin as firstline therapy for metastatic breast cancer. J Clin Oncol 1988; 6, 12: 1811–1814.
  • Goldhirsch A, Gelber RD, Rudenstam CM et al. Patterns of first relapse in breast cancer patients with node-negative disease: the effect of a single cycle of adjuvant perioperative chemotherapy (PeCT). Proc ASCO 1989; Abst 68.
  • Bonadonna G, Valagussa P. Current status of adjuvant chemotherapy for breast cancer. Sem Oncol 1987; 14, 1: 8–22.
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  • Aapro MS, Plezia PM, Alberts DS et al. Double-blind crossover study of the antiemetic efficacy of high-dose dexamethasone versus high-dose metoclopramide. Proc Am Soc Clin Oncol 1983; 2: 93.
  • Cassileth PA, Lusk EJ, Torri S et al. Antiemetic efficacy of dexamethasone therapy in patients receiving cancer chemotherapy. Arch Intern Med 1983; 143: 1347–1349.
  • Campora E, Chiara S, Bruzzi P et al. The antiemetic efficacy of methylprednisolone compared with metoclopramide in outpatients receiving adjuvant CMF chemotherapy for breast cancer: a randomized trial. Tumori 1985; 71: 459–462.
  • Lazio J, Clark RA, Hanson DC et al. Lorazepam in cancer patients treated with cisplatin: a drug with antiemetic, amnestic and anxiolytic effects. J Clin Oncol 1985; 3: 864–869.
  • Campora E, Sertoli MR, Chiara S et al. Improved tolerance to chemotherapy with lorazepam in outpatients with refractory nausea and vomiting. Farm Ter 1986; 3, 2: 115–117.
  • Mantel N. Chi-square tests with one degree of freedom; extention of the Mantel-FIaenszel procedure. J Am Stat Assoc 1963; 58: 690–700.

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