Determination of synergy between sulbactam, meropenem and colistin in carbapenem-resistant Klebsiella pneumoniae and Acinetobacter baumannii isolates and correlation with the molecular mechanism of resistance

References

• Bergen PJ , Bulman ZP , Saju S , Bulitta JB , Landersdorfer C , Forrest A , et al. Polymyxin combinations: pharmacokinetics and pharmacodynamics for rationale use. Pharmacotherapy . 2015;35:34–42.
   PubMed Web of Science ®Google Scholar
• Mammina C , Bonura C , Di Bernardo F , Aleo A , Fasciana T , Sodano C , et al. 2012. Ongoing spread of colistin-resistant Klebsiella pneumoniae in different wards of an acute general hospital, Italy, June to December 2011. Euro Surveill, 2012;17(33):pii 20248.
   Google Scholar
• Bogdanovich T , Adams-Haduch JM , Tian GB , Nguyen MH , Kwak EJ , Muto CA , et al. Colistin-resistant, Klebsiella pneumoniae carbapenemase (KPC)-producing Klebsiella pneumoniae belonging to the international epidemic clone ST258. Clin Infect Dis . 2011;53:373–6.
   PubMed Web of Science ®Google Scholar
• Mezzatesta ML , Gona F , Caio C , Petrolito V , Sciortino D , Sciacca A , et al. Outbreak of KPC- 3-producing, and colistin-resistant, Klebsiella pneumoniae infections in two Sicilian hospitals. Clin Microbiol Infect . 2011;17:1444–7.
   PubMed Web of Science ®Google Scholar
• Toth A , Damjanova I , Puskas E , Janvari L , Farkas M , Dobak A , et al. Emergence of a colistin-resistant KPC-2-producing Klebsiella pneumoniae ST258 clone in Hungary. Eur J Clin Microbiol Infect Dis . 2010;29:765–9.
   PubMed Web of Science ®Google Scholar
• Kontopoulou K , Protonotariou E , Vasilakos K , Kriti M , Koteli A , Antoniadou E , et al. Hospital outbreak caused by Klebsiella pneumoniae producing KPC-2 beta-lactamase resistant to colistin. J Hosp Infect . 2010;76:70–3.
   PubMed Web of Science ®Google Scholar
• Goel G , Hmar L , Sarkar De M , Bhattacharya S , Chandy M . Colistin-resistant Klebsiella pneumoniae: report of a cluster of 24 cases from a new oncology center in eastern India. Infect Control Hosp Epidemiol . 2014;35:1076–7.
   PubMed Web of Science ®Google Scholar
• Doi Y , Paterson DL . Carbapenemase-producing Enterobacteriaceae . Semin Respir Crit Care Med . 2015;36:74–84.
   PubMed Web of Science ®Google Scholar
• Clinical and Laboratory Standards Institute . [CLSI document M100-S23] Performance standards for antimicrobial susceptibility testing; twenty-third informational supplement . Wayne, PA: Clinical and Laboratory Standards Institute; 2013.
   Google Scholar
• Gracia LS . Clinical microbiology procedures handbook . 2nd (update) edn. Santa Monica, CA: ASM Press; 2007.
   Google Scholar
• Nordmann P , Poirel L , Dortet L . Rapid detection of carbapenemase-producing Enterobacteriaceae . Emerg Infect Dis . 2012;18:1503–7.
   PubMed Web of Science ®Google Scholar
• Dortet L , Poirel L , Errera C , Nordmann P . CarbAcineto NP test for rapid detection of carbapenemase-producing Acinetobacter spp. J Clin Microbiol . 2014;52:2359–64.
   PubMed Web of Science ®Google Scholar
• Poirel L , Walsh TR , Cuvillier V , Nordmann P . Multiplex PCR for detection of acquired carbapenemase genes. Diagn Microbiol Infect Dis . 2011;70:119–23.
   PubMed Web of Science ®Google Scholar
• Yigit H , Queenan AM , Anderson GJ , Domenech-Sanchez A , Biddle JW , Steward CD , et al. Novel carbapenem-hydrolyzing beta-lactamase, KPC-1, from a carbapenem-resistant strain of Klebsiella pneumoniae . Antimicrob Agents Chemother . 2001;45:1151–61.
   PubMed Web of Science ®Google Scholar
• Poirel L , Castanheira M , Carrer A , Rodriguez CP , Jones RN , Smayevsky J , et al. OXA-163, an OXA-48-related class D beta-lactamase with extended activity toward expanded-spectrum cephalosporins. Antimicrob Agents Chemother . 2011;55:2546–51.
   PubMed Web of Science ®Google Scholar
• Nordmann P , Boulanger AE , Poirel L . NDM-4 metallo-beta-lactamase with increased carbapenemase activity from Escherichia coli . Antimicrob Agents Chemother . 2012;56:2184–6.
   PubMed Web of Science ®Google Scholar
• Amudhan SM , Sekar U , Arunagiri K , Sekar B . OXA beta-lactamase-mediated carbapenem resistance in Acinetobacter baumannii . Indian J Med Microbiol . 2011;29:269–74.
   PubMed Web of Science ®Google Scholar
• Magiorakos AP , Srinivasan A , Carey RB , Carmeli Y , Falagas ME , Giske CG , et al. Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance. Clin Microbiol Infect . 2012;18:268–81.
   PubMed Web of Science ®Google Scholar
• Choi JY , Park YS , Cho CH , Shin SY , Song YG , Yong D , et al. Synergic in-vitro activity of imipenem and sulbactam against Acinetobacter baumannii . Clin Microbiol Infect . 2004;10:1098–01.
   PubMed Web of Science ®Google Scholar
• Ko WC , Lee HC , Chiang SR , Yan JJ , Wu JJ , Lu CL , et al. In vitro and in vivo activity of meropenem and sulbactam against a multidrug-resistant Acinetobacter baumannii strain. J Antimicrob Chemother . 2004;53:393–5.
   PubMed Web of Science ®Google Scholar
• Song JY , Kee SY , Hwang IS , Seo YB , Jeong HW , Kim WJ , et al. In vitro activities of carbapenem/sulbactam combination, colistin, colistin/rifampicin combination and tigecycline against carbapenem-resistant Acinetobacter baumannii . J Antimicrob Chemother . 2007;60:317–22.
   PubMed Web of Science ®Google Scholar
• Sheng WH , Wang JT , Li SY , Lin YC , Cheng A , Chen YC , et al. Comparative in vitro antimicrobial susceptibilities and synergistic activities of antimicrobial combinations against carbapenem-resistant Acinetobacter species: Acinetobacter baumannii versus Acinetobacter genospecies 3 and 13TU. Diagn Microbiol Infect Dis . 2011;70:380–6.
   PubMed Web of Science ®Google Scholar
• Principe L , Capone A , Mazzarelli A , D'Arezzo S , Bordi E , Di Caro A , et al. In vitro activity of doripenem in combination with various antimicrobials against multidrug-resistant Acinetobacter baumannii: possible options for the treatment of complicated infection. Microb Drug Resist . 2013;19:407–14.
   PubMed Web of Science ®Google Scholar
• Pongpech P , Amornnopparattanakul S , Panapakdee S , Fungwithaya S , Nannha P , Dhiraputra C , et al. Antibacterial activity of carbapenem-based combinations againts multidrug-resistant Acinetobacter baumannii . J Med Assoc Thai . 2010;93:161–71.
   PubMedGoogle Scholar
• Cikman A , Ceylan MR , Parlak M , Karahocagil MK , Berktas M . [Evaluation of colistin- ampicillin/sulbactam combination efficacy in imipenem-resistant Acinetobacter baumannii strains]. Mikrobiyol Bul . 2013;47:147–51.
   PubMed Web of Science ®Google Scholar
• Zusman O , Avni T , Leibovici L , Adler A , Friberg L , Stergiopoulou T , et al. Systematic review and meta-analysis of in vitro synergy of polymyxins and carbapenems. Antimicrob Agents Chemother . 2013;57:5104–11.
   PubMed Web of Science ®Google Scholar
• Tan TY , Lim TP , Lee WH , Sasikala S , Hsu LY , Kwa AL . In vitro antibiotic synergy in extensively drug-resistant Acinetobacter baumannii: the effect of testing by time-kill, checkerboard, and Etest methods. Antimicrob Agents Chemother . 2011;55:436–8.
   PubMed Web of Science ®Google Scholar
• White RL , Burgess DS , Manduru M , Bosso JA . Comparison of three different in vitro methods of detecting synergy: time-kill, checkerboard, and E test. Antimicrob Agents Chemother . 1996;40:1914–8.
   PubMed Web of Science ®Google Scholar
• Jernigan MG , Press EG , Nguyen MH , Clancy CJ , Shields RK . The combination of doripenem and colistin is bactericidal and synergistic against colistin-resistant, carbapenemase-producing Klebsiella pneumoniae . Antimicrob Agents Chemother . 2012;56:3395–8.
   PubMed Web of Science ®Google Scholar
• Souli M , Rekatsina PD , Chryssouli Z , Galani I , Giamarellou H , Kanellakopoulou K . Does the activity of the combination of imipenem and colistin in vitro exceed the problem of resistance in metallo-beta-lactamase-producing Klebsiella pneumoniae isolates? Antimicrob Agents Chemother . 2009;53:2133–5.
   PubMed Web of Science ®Google Scholar
• Santimaleeworagun W , Wongpoowarak P , Chayakul P , Pattharachayakul S , Tansakul P , Garey KW . In vitro activity of colistin or sulbactam in combination with fosfomycin or imipenem against clinical isolates of carbapenem-resistant Acinetobacter baumannii producing OXA-23 carbapenemases. Southeast Asian J Trop Med Public Health . 2011;42:890–900.
   PubMed Web of Science ®Google Scholar
• Clancy CJ , Chen L , Hong JH , Cheng S , Hao B , Shields RK , et al. Mutations of the ompK36 porin gene and promoter impact responses of sequence type 258, KPC-2-producing Klebsiella pneumoniae strains to doripenem and doripenem-colistin. Antimicrob Agents Chemother . 2013;57:5258–65.
   PubMed Web of Science ®Google Scholar
• Hong JH , Clancy CJ , Cheng S , Shields RK , Chen L , Doi Y , et al. Characterization of porin expression in Klebsiella pneumoniae Carbapenemase (KPC)-producing K. pneumoniae identifies isolates most susceptible to the combination of colistin and carbapenems. Antimicrob Agents Chemother . 2013;57:2147–53.
   PubMed Web of Science ®Google Scholar
• Clancy CJ , Hao B , Shields RK , Chen L , Perlin DS , Kreiswirth BN , et al. Doripenem, gentamicin, and colistin, alone and in combinations, against gentamicin-susceptible, KPC- producing Klebsiella pneumoniae strains with various ompK36 genotypes. Antimicrob Agents Chemother . 2014;58:3521–5.
   PubMed Web of Science ®Google Scholar
• Biancofiore G , Tascini C , Bisa M , Gemignani G , Bindi ML , Leonildi A , et al. Colistin, meropenem and rifampin in a combination therapy for multi-drug-resistant Acinetobacter baumannii multifocal infection. A case report. Minerva Anestesiol . 2007;73:181–5.
   PubMed Web of Science ®Google Scholar
• Lee CH , Tang YF , Su LH , Chien CC , Liu JW . Antimicrobial effects of varied combinations of meropenem, sulbactam, and colistin on a multidrug-resistant Acinetobacter baumannii isolate that caused meningitis and bacteremia. Microb Drug Resist . 2008;14:233–7.
   PubMed Web of Science ®Google Scholar
• Oliva A , Mascellino MT , Cipolla A , D'Abramo A , De Rosa A , Savinelli S , et al. Therapeutic strategy for pandrug-resistant Klebsiella pneumoniae severe infections: short-course treatment with colistin increases the in vivo and in vitro activity of double carbapenem regimen. Int J Infect Dis . 2015;33:132–4.
   PubMed Web of Science ®Google Scholar
• Perrott J , Mabasa VH , Ensom MH . Comparing outcomes of meropenem administration strategies based on pharmacokinetic and pharmacodynamic principles: a qualitative systematic review. Ann Pharmacother . 2010;44:557–64.
   PubMed Web of Science ®Google Scholar
• Jaruratanasirikul S , Sriwiriyajan S , Punyo J . Comparison of the pharmacodynamics of meropenem in patients with ventilator-associated pneumonia following administration by 3- hour infusion or bolus injection. Antimicrob Agents Chemother . 2005;49:1337–9.
   PubMed Web of Science ®Google Scholar