24,359
Views
7
CrossRef citations to date
0
Altmetric
Antimicrobial Original Research Paper

Multi-drug-resistant Gram-negative bacteria causing urinary tract infections: a review

, ORCID Icon &

References

  • Bonkat G, Pickard R, Bartoletti R, Bruyère F, Cai T, Geerlings SE, et al. Guidelines on urological infections. EAU. 2017.
  • Flores-Mireles AL, Walker JN, Caparon M, Hultgren SJ. Urinary tract infections: epidemiology, mechanisms of infection and treatment options. Nat Rev Microbiol. 2015;13(5):269–84.10.1038/nrmicro3432
  • Gupta K, Hooton TM, Naber KG, Wullt B, Colgan R, Miller LG, et al. Infectious Diseases Society of America; European Society for Microbiology and Infectious Diseases. International clinical practice guidelines for the treatment of acute uncomplicated cystitis and pyelonephritis in women: a 2010 update by the Infectious Diseases Society of America and the European Society for Microbiology and Infectious Diseases. Clin Infect Dis. 2011;52(5):e103–2.10.1093/cid/ciq257
  • Oteo J, Pérez-Vázquez M, Campos J. Extended-spectrum [beta]-lactamase producing Escherichia coli: changing epidemiology and clinical impact. Curr Opin Infect Dis. 2010;23(4):320–6.10.1097/QCO.0b013e3283398dc1
  • Boyle DP, Zembower TR. Epidemiology and management of emerging drug-resistant Gram-negative bacteria: extended-spectrum β-lactamases and beyond. Urol Clin North Am. 2015;42(4):493–505.10.1016/j.ucl.2015.05.005
  • Cantón R, Coque TM. The CTX-M beta-lactamase pandemic. Curr Opin Microbiol. 2006;9(5):466–75.10.1016/j.mib.2006.08.011
  • Bauernfeind A, Grimm H, Schweighart S. A new plasmidic cefotaximase in a clinical isolate of Escherichia coli. Infection. 1990;18(5):294–8.10.1007/BF01647010
  • Bauernfeind A, Casellas JM, Goldberg M, Holley M, Jungwirth R, Mangold P, et al. A new plasmidic cefotaximase from patients infected with Salmonella typhimurium. Infection. 1992;20(3):158–63.10.1007/BF01704610
  • European Centre for Disease Prevention and Control. Antimicrobial resistance surveillance in Europe 2014. Annual Report of the European Antimicrobial Resistance Surveillance Network (EARS-Net). Stockholm: ECDC; 2014. p. 2015.
  • Hawser SP, Bouchillon SK, Lascols C, Hackel M, Hoban DJ, Badal RE, et al. Susceptibility of European Escherichia coli clinical isolates from intra-abdominal infections, extended-spectrum β-lactamase occurrence, resistance distribution, and molecular characterization of ertapenem-resistant isolates (SMART 2008–2009). Clin Microbiol Infect. 2012;18(3):253–9.10.1111/j.1469-0691.2011.03550.x
  • Hawser SP, Bouchillon SK, Lascols C, Hackel M, Hoban DJ, Badal RE, et al. Susceptibility of Klebsiella pneumoniae Isolates from Intra-Abdominal Infections and Molecular Characterization of Ertapenem-Resistant Isolates. Antimicrob Agents Chemother. 2011;55(8):3917–21.10.1128/AAC.00070-11
  • Morrissey I, Hackel M, Badal R, Bouchillon S, Hawser S, Biedenbach D. A review of ten years of the study for monitoring antimicrobial resistance trends (SMART) from 2002 to 2011. Pharmaceuticals (Basel). 2013;6(11):1335–46.10.3390/ph6111335
  • Lascols C, Hackel M, Marshall SH, Hujer AM, Bouchillon S, Badal R, et al. Increasing prevalence and dissemination of NDM-1 metallo-β-lactamase in India: data from the SMART study (2009). J Antimicrob Chemother. 2011;66(9):1992–7.10.1093/jac/dkr240
  • Lascols C, Hackel M, Hujer AM, Marshall SH, Bouchillon SK, Hoban DJ, et al. Using nucleic acid microarrays to perform molecular epidemiology and detect novel β-lactamases: a snapshot of extended-spectrum β-lactamases throughout the world. J Clin Microbiol. 2012;50(5):1632–9.10.1128/JCM.06115-11
  • Sheng WH, Badal RE, Hsueh PR, SMART ProGram. Distribution of extended-spectrum β-lactamases, AmpC β-lactamases, and carbapenemases among Enterobacteriaceae isolates causing intra-abdominal infections in the Asia-Pacific region: results of the study for Monitoring Antimicrobial Resistance Trends (SMART). Antimicrob Agents Chemother. 2013;57(7):2981–8.10.1128/AAC.00971-12
  • Vardakas KZ, Legakis NJ, Triarides N, Falagas ME. Susceptibility of contemporary isolates to fosfomycin: a systematic review of the literature. Int J Antimicrob Agents. 2016;47(4):269–85.10.1016/j.ijantimicag.2016.02.001
  • Mezzatesta ML, La Rosa G, Maugeri G, Zingali T, Caio C, Novelli A, et al. In vitro activity of fosfomycin trometamol and other oral antibiotics against multidrug-resistant uropathogens. Int J Antimicrob Agents. 2017;49(6):763–6.10.1016/j.ijantimicag.2017.01.020
  • Cho YH, Jung SI, Chung HS, Yu HS, Hwang EC, Kim SO, et al. Antimicrobial susceptibilities of extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae in health care-associated urinary tract infection: focus on susceptibility to fosfomycin. Int Urol Nephrol. 2015;47(7):1059–66.10.1007/s11255-015-1018-9
  • Sultan A, Rizvi M, Khan F, Sami H, Shukla I, Khan HM. Increasing antimicrobial resistance among uropathogens: Is fosfomycin the answer? Urol Ann. 2015;7(1):26–30.10.4103/0974-7796.148585
  • Khan IU, Mirza IA, Ikram A, Ali S, Hussain A, Ghafoor T. In vitro activity of fosfomycin tromethamine against extended spectrum beta-lactamase producing urinary tract bacteria. J Coll Physicians Surg Pak. 2014;24(12):914–917.
  • Cagan Aktas S, Gencer S, Batırel A, Hacıseyitoglu D, Ozer S. Fosfomycin susceptibility of urinary Escherichia coli isolates producing extended-spectrum beta-lactamase according to CLSI and EUCAST recommendations. Mikrobiyol Bul. 2014;48(4):545–555. [ in Turkish].
  • Sorlozano A, Jimenez-Pacheco A, de Dios Luna Del Castillo J, Sampedro A, Martinez-Brocal A, Miranda-Casas C, et al. Evolution of the resistance to antibiotics of bacteria involved in urinary tract infections: a 7-year surveillance study. Am J Infect Control. 2014;42(10):1033–8.10.1016/j.ajic.2014.06.013
  • Kresken M, Pfeifer Y, Hafner D, Wresch R, Korber-Irrgang B. Occurrence of multidrug resistance to oral antibiotics among Escherichia coli urine isolates from outpatient departments in Germany: extended-spectrum beta-lactamases and the role of fosfomycin. Int J Antimicrob Agents. 2014;44(4):295–300.10.1016/j.ijantimicag.2014.05.020
  • Seo MR, Kim SJ, Kim Y, Kim J, Choi TY, Kang JO, et al. Susceptibility of Escherichia coli from community-acquired urinary tract infection to fosfomycin, nitrofurantoin, and temocillin in Korea. J Korean Med Sci. 2014;29(8):1178–1181.10.3346/jkms.2014.29.8.1178
  • Villar HE, Jugo MB, Macan A, Visser M, Hidalgo M, Maccallini GC. Frequency and antibiotic susceptibility patterns of urinary pathogens in male outpatients in Argentina. J Infect Dev Ctries. 2014;8(6):699–704.
  • Gupta V, Rani H, Singla N, Kaistha N, Chander J. Determination of extended-spectrum beta-lactamases and AmpC production in uropathogenic isolates of Escherichia coli and susceptibility to fosfomycin. J Lab Physicians. 2013;5(2):90–93.10.4103/0974-2727.119849
  • Lai B, Zheng B, Li Y, Zhu S, Tong Z. In vitro susceptibility of Escherichia coli strains isolated from urine samples obtained in mainland China to fosfomycin trometamol and other antibiotics: a 9-year surveillance study (2004–2012). BMC Infect Dis. 2014;14:66.10.1186/1471-2334-14-66
  • Qiao LD, Chen S, Yang Y, Zhang K, Zheng B, Guo HF, et al. Characteristics of urinary tract infection pathogens and their in vitro susceptibility to antimicrobial agents in China: data from a multicenter study. BMJ Open. 2013;3(12):e004152.10.1136/bmjopen-2013-004152
  • Karlowsky JA, Denisuik AJ, Lagace-Wiens PR, Adam HJ, Baxter MR, Hoban DJ, et al. In vitro activity of fosfomycin against Escherichia coli isolated from patients with urinary tract infections in Canada as part of the CANWARD surveillance study. Antimicrob Agents Chemother. 2014;58(2):1252–6.10.1128/AAC.02399-13
  • Demir T, Buyukguclu T. Evaluation of the in vitro activity of fosfomycin tromethamine against Gram-negative bacterial strains recovered from community- and hospital-acquired urinary tract infections in Turkey. Int J Infect Dis. 2013;17(11):e966–70.10.1016/j.ijid.2013.04.005
  • Sahni RD, Balaji V, Varghese R, John J, Tansarli GS, Falagas ME. Evaluation of fosfomycin activity against uropathogens in a fosfomycin-naive population in South India: a prospective study. Future Microbiol. 2013;8(5):675–80.10.2217/fmb.13.31
  • Rodríguez-Avial C, Rodríguez-Avial I, Hernández E, Picazo JJ. Increasing prevalence of fosfomycin resistance in extended-spectrum-beta-lactamase-producing Escherichia coli urinary isolates (2005–2009–2011). Rev Esp Quimioter. 2013;26(1):43–46. [in Spanish].
  • Fournier D, Chirouze C, Leroy J, Cholley P, Talon D, Plésiat P, et al. Alternatives to carbapenems in ESBL-producing Escherichia coli infections. Med Mal Infect. 2013;43(2):62–6.10.1016/j.medmal.2013.01.006
  • Bonkat G, Muller G, Braissant O, Frei R, Tschudin-Suter S, Rieken M, et al. Increasing prevalence of ciprofloxacin resistance in extended-spectrum-beta-lactamase-producing Escherichia coli urinary isolates. World J Urol. 2013;31:1427–32.10.1007/s00345-013-1031-5
  • Araj GF, Jaber FA. In vitro activity of fosfomycin and other antimicrobials against uropathogenic Escherichia coli and Klebsiella pneumoniae at a tertiary care center in Lebanon. J Med Liban. 2012;60(3):142–147.
  • Briongos-Figuero LS, Gómez-Traveso T, Bachiller-Luque P, Domínguez-Gil González M, Gómez-Nieto A, Palacios-Martín T, et al. Epidemiology, risk factors and comorbidity for urinary tract infections caused by extended-spectrum beta-lactamase (ESBL)-producing enterobacteria. Int J Clin Pract. 2012;66(9):891–6.10.1111/ijcp.2012.66.issue-9
  • Meier S, Weber R, Zbinden R, Ruef C, Hasse B. Extended-spectrum beta-lactamase-producing Gram-negative pathogens in community-acquired urinary tract infections: an increasing challenge for antimicrobial therapy. Infection. 2011;39(4):333–40.10.1007/s15010-011-0132-6
  • Liu HY, Lin HC, Lin YC, Yu SH, Wu WH, Lee YJ. Antimicrobial susceptibilities of urinary extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae to fosfomycin and nitrofurantoin in a teaching hospital in Taiwan. J Microbiol Immunol Infect. 2011;44(5):364–8.10.1016/j.jmii.2010.08.012
  • den Heijer CD, Donker GA, Maes J, Stobberingh EE. Antibiotic susceptibility of unselected uropathogenic Escherichia coli from female Dutch general practice patients: a comparison of two surveys with a 5 year interval. J Antimicrob Chemother. 2010;65(10):2128–33.10.1093/jac/dkq286
  • Auer S, Wojna A, Hell M. Oral treatment options for ambulatory patients with urinary tract infections caused by extended-spectrum-beta-lactamase-producing Escherichia coli. Antimicrob Agents Chemother. 2010;54(9):4006–8.10.1128/AAC.01760-09
  • Wachino J, Yamane K, Suzuki S, Kimura K, Arakawa Y. Prevalence of Fosfomycin Resistance among CTX-M-Producing Escherichia coli Clinical Isolates in Japan and Identification of Novel Plasmid-Mediated Fosfomycin-Modifying Enzymes. Antimicrob Agents Chemother. 2010;54(7):3061–4.10.1128/AAC.01834-09
  • Tena D, González-Praetorius A, González JC, Heredero E, Illescas S, de Baranda CS, et al. Changes in the antimicrobial susceptibility of Escherichia coli isolates from community diagnosed urinary tract infections during the period 2003–2007. Multicentre study in Castilla la Mancha (Spain). Rev Esp Quimioter. 2010;23(1):36–42 . [in Spanish].
  • Chislett RJ, White G, Hills T, Turner DP. Fosfomycin susceptibility among extended-spectrum-beta-lactamase-producing Escherichia coli in Nottingham UK. J Antimicrob Chemother. 2010;65(5):1076–7.10.1093/jac/dkq051
  • Mathers AJ, Peirano G, Pitout JD. The Role of epidemic resistance plasmids and international high-risk clones in the spread of multidrug-resistant Enterobacteriaceae. Clin Microbiol Rev. 2015;28(3):565–91.10.1128/CMR.00116-14
  • Clermont O, Lavollay M, Vimont S, Deschamps C, Forestier C, Branger C, et al. The CTX-M-15-producing Escherichia coli diffusing clone belongs to a highly virulent B2 phylogenetic subgroup. J Antimicrob Chemother. 2008;61(5):1024–8.10.1093/jac/dkn084
  • Lavigne JP, Vergunst AC, Goret L, Sotto A, Combescure C, Blanco J, et al. Virulence potential and genomic mapping of the worldwide clone Escherichia coli ST131. PLoS ONE. 2012;7(3):e34294.10.1371/journal.pone.0034294
  • Hussain A, Ewers C, Nandanwar N, Guenther S, Jadhav S, Wieler LH, et al. Multiresistant uropathogenic Escherichia coli from a region in India where urinary tract infections are endemic: genotypic and phenotypic characteristics of sequence type 131 isolates of the CTX-M-15 extended-spectrum-β-lactamase-producing lineage. Antimicrob Agents Chemother. 2012;56(12):6358–65.10.1128/AAC.01099-12
  • López-Cerero L, Navarro MD, Bellido M, Martín-Peña A, Viñas L, Cisneros JM, et al. Escherichia coli belonging to the worldwide emerging epidemic clonal group O25b/ST131: risk factors and clinical implications. J Antimicrob Chemother. 2014;69(3):809–14.10.1093/jac/dkt405
  • Oteo J, Orden B, Bautista V, Cuevas O, Arroyo M, Martínez-Ruiz R, et al. CTX-M-15-producing urinary Escherichia coli O25b-ST131-phylogroup B2 has acquired resistance to fosfomycin. J Antimicrob Chemother. 2009;64(4):712–7.10.1093/jac/dkp288
  • Peleg AY, Hooper DC. Hospital-acquired infections due to Gram-negative bacteria. N Engl J Med. 2010;362(19):1804–13.10.1056/NEJMra0904124
  • Carrër A, Nordmann P. CTX-M-15-producing Klebsiella pneumoniae: a change in the epidemiology of ESBL. Pathol Biol (Paris). 2011;59(6):e133–5.
  • Knothe H, Shah P, Krcmery V, Antal M, Mitsuhashi S. Transferable resistance to cefotaxime, cefoxitin, cefamandole and cefuroxime in clinical isolates of Klebsiella pneumoniae and Serratia marcescens. Infection. 1983;11(6):315–7.10.1007/BF01641355
  • Livermore DM, Hawkey PM. CTX-M changing the face of ESBLs in the UK. J Antimicrob Chemother. 2005;56(3):451–4.10.1093/jac/dki239
  • Mugnaioli C, Luzzaro F, De Luca F, Brigante G, Perilli M, Amicosante G, et al. CTX-M type ESBL in Italy: molecular epidemiology of an emerging countryside problem. Antimicrob Agents Chemother. 2006;50(8):2700–6.10.1128/AAC.00068-06
  • Hernández JR, Martínez-Martínez L, Cantón R, Coque TM, Pascual A, Spanish Group for Nosocomial Infections (GEIH). Nationwide study of E. coli and K. pneumoniae producing ESBL in Spain. Antimicrob Agents Chemother. 2005:49(5):2122–2215.
  • Poirel L, Bonnin RA, Nordmann P. Genetic support and diversity of acquired extended-spectrum β-lactamases in Gram-negative rods. Infect Genet Evol. 2012;12(5):883–93.10.1016/j.meegid.2012.02.008
  • Younes A, Hamouda A, Dave J, Amyes S. Prevalence of transferable blaCTX-M-15 from hospital-and community-acquired Klebsiella pneumoniae isolates in Scotland. J Antimicrob Chemother. 2011;66(2):313–8.10.1093/jac/dkq453
  • Coelho A, Mirelis B, Alonso-Tarrés C, Larrosa MN, Miró E, Abad RC, et al. Detection of three stable genetic clones of CTX-M-15-producing Klebsiella pneumoniae in the Barcelona metropolitan area Spain. J Antimicrob Chemother. 2009;64(4):862–4.10.1093/jac/dkp264
  • Coelho A, González-López JJ, Miró E, Alonso-Tarrés C, Mirelis B, Larrosa MN, et al. Characterisation of the CTX-M-15-encoding gene in Klebsiella pneumoniae strains from the Barcelona metropolitan area: plasmid diversity and chromosomal integration. Int J Antimicrob Agents. 2010;36(1):73–8.10.1016/j.ijantimicag.2010.03.005
  • Mshana SE, Fritzenwanker M, Falgenhauer L, Domann E, Hain T, Chakraborty T, et al. Molecular epidemiology and characterization of an outbreak causing Klebsiella pneumoniae clone carrying chromosomally located bla(CTX-M-15) at a German University-Hospital. BMC Microbiol. 2015;15:122.10.1186/s12866-015-0460-2
  • Alibi S, Ferjani A, Boukadida J. Molecular characterization of extended spectrum beta-lactamases produced by Klebsiella pneumoniae clinical strains from a Tunisian Hospital. Med Mal Infect. 2015;45(4):139–43.10.1016/j.medmal.2015.01.010
  • Kopacz J, Mariano N, Colon-Urban R, Sychangco P, Wehbeh W, Segal-Maurer S, et al. Identification of extended-spectrum-beta-lactamase-positive Klebsiella pneumoniae urinary tract isolates harboring KPC and CTX-M beta-lactamases in non hospitalized patients. Antimicrob Agents Chemother. 2013;57(10):5166–9.10.1128/AAC.00043-13
  • Morfín-Otero R, Mendoza-Olazarán S, Silva-Sánchez J, Rodríguez-Noriega E, Laca-Díaz J, Tinoco-Carrillo P, et al. Characterization of Enterobacteriaceae isolates obtained from a tertiary care hospital in Mexico, which produces extended-spectrum beta-lactamase. Microb Drug Resist. 2013;19(5):378–83.10.1089/mdr.2012.0263