161
Views
18
CrossRef citations to date
0
Altmetric
Antimicrobial Original Research Paper

High prevalence of imipenem-resistant and metallo-beta-lactamase-producing Pseudomonas aeruginosa in the Burns Hospital in Tunisia: detection of a novel class 1 integron

, , , ORCID Icon, &
Pages 120-126 | Received 15 May 2018, Accepted 08 Feb 2019, Published online: 08 Mar 2019

References

  • Morrison AJ, Wenzel RP. Epidemiology of infections due to Pseudomonas aeruginosa. Rev Infect Dis. 1984;6(3):S627–S42.
  • Strateva T, Yordanov D. Pseudomonas aeruginosa a phenomenon of bacterial resistance. J Med Microbiol. 2009;58:1133–48.
  • Shen J, Pan Y, Fang Y. Role of the outer membrane protein oprd2 in carbapenem-resistance mechanisms of Pseudomonas aeruginosa. PLoS One. 2015;10:e0139995.
  • Oliver A, Mulet X, López-Causapé C, Juan C. The increasing threat of Pseudomonas aeruginosa high-risk clones. Drug Resist Updat. 2015;21–22:41–59.
  • Rojo-Bezares B, Estepa V, Cebollada R, De Toro M, Somalo S, Seral C et al. Carbapenem-resistant Pseudomonas aeruginosa strains from a Spanish hospital: characterization of metallo-beta-lactamases, porin OprD and integrons. Int J Med Microbiol. 2014;304(3–4):405–14.
  • Hammami S, Boutiba I, Ghozi R, Saidani M, Slim A, Ben Redjeb S. Nosocomial outbreak of imipenem resistant Pseudomonas aeruginosa producing VIM-2 metallo β-lactamase in a kidney transplantation unit. Diagn Pathol. 2011;6:106.
  • Hauser AR. The type III secretion system of Pseudomonas aeruginosa: infection by injection. Nat Rev Microbiol. 2009;7:654–65.
  • Stehling EG, Leite DS, Silveira WD. Molecular typing and biological characteristics of Pseudomonas aeruginosa isolated from cystic fibrosis patients in Brazil. Braz J Infect Dis. 2010;4(5):462–7.
  • Moradali MF, Ghods S, Rehm BHA. Pseudomonas aeruginosa lifestyle: a paradigm for adaptation, survival and persistence. Front Cell Infect Microbiol. 2017;7:39.
  • Achour W, Abbassi MS, Cherif A, Jabnoun S, Khrouf N, Ben Hassen A. Nosocomial respiratory infection due to an imipenem-resistant Pseudomonas aeruginosa O:12 strain in a Tunis's neonatal intensive care unit. J Pathol Biol. 2006;54(10):596–9.
  • Ben Abdallah H, Noomen S, Ben Elhadj Khélifa A, Sahnoun O, Elargoubi A, Mastouri M. Susceptibility patterns of Pseudomonas aeruginosa strains isolated in the Monastir region, Tunisia. Méd Maladie Infect. 2008;38:554–6.
  • Mansour W, Poirel L, Bettaieb D, Bouallégue O, Boujaafer N, Nordmann P. Metallo-lactamase producing Pseudomonas aeruginosa isolates in Tunisia. Diagn Microbiol Infect Dis. 2009;64:458–61.
  • Thabet L, Zoghlami A, Kanzari L, Boukadida J, Messadi A, Ghanem A. Profil épidémiologique et résistance aux antibiotiques des Souches de Pseudomonas aeruginosa isolées au centre de Traumatologie et Grands Brûlés en Tunisie durant trois ans. La tunisie Med. 2012;90 (011):803–6.
  • MacFaddin JF. Biochemical Tests for Identification of Medical Bacteria. 2nd ed. Waverly Press Inc, Baltimor USA. 2000;64–7.
  • Wesam AH. Molecular identification of antibiotics resistant Pseudomonas aeruginosa .Wt Aust J Basic Appl Sci. 2009;3:2144–53.
  • Lee K, Chong Y, Shin HB, Kim YA, Yong D, Yum JH. Modified Hodge and EDTA-disk synergy tests to screen metallo-b-lactamase-producing strains of Pseudomonas and Acinetobacter species. Clin Microbiol Infect. 2001;7:88–91.
  • Poirel L, Héritier C, Tolün V, Nordmann P. Emergence of oxacillinase-mediated resistance to imipenem in Klebsiella pneumoniae. Antimicrob Agents Chemother. 2004;48(1):15–22.
  • Ellington MJ, Kistler J, Livermore DM, Woodford N. Multiplex PCR for rapid detection of genes encoding acquired metallo-b-lactamases. J Antimicrob Chemother. 2007;59:321–2.
  • Naas T, Cuzon G, Truong HV, Nordmann P. Role of ISKpn7 and deletions in blaKPC gene expression. Antimicrob Agents Chemother. 2012;56(9):4753–9.
  • Wolter DJ, Hanson ND, Lister P D. Insertional inactivation of oprD in clinical isolates of Pseudomonas aeruginosa leading to carbapenem resistance. FEMS Microbiol Lett. 2004;236:137–43.
  • Gutiérrez O, Juan C, Cercenado E, Navarro F, Bouza E, Coll P et al. Molecular epidemiology and mechanisms of carbapenem resistance in Pseudomonas aeruginosa isolates from Spanish hospitals. Antimicrob Agents Chemother. 2007;51:4329–35.
  • Rojo-Bezares B, Estepa V, De Toro M, Undabeitia E, Olarte I, Torres C et al. A novel class 1 integron array carrying blaVIM-2 genes and a new insertion sequence in a Pseudomonas aeruginosa strain isolated from a Spanish hospital. J Med Microbiol. 2011;60:1053–4.
  • Curran B, Jonas D, Grundmann H, Pitt T, Dowson CG. Development of a multilocus sequence typing scheme for the opportunistic pathogen Pseudomonas aeruginosa. J Clin Microbiol. 2004;42:5644–9.
  • Petit SM, Lavenir R, Colinon-Dupuich C, Boukerb AM, Cholley P, Bertrand X et al. Lagooning of wastewaters favors dissemination of clinically relevant Pseudomonas aeruginosa. Res Microbiol. 2013;164:856–66.
  • ALmaamory IAAS, Ibraheam IA, Azize HW. Pseudomonas aeruginosa; antibiotics susceptibility among patients of nosocomial infection in Hillah City, Iraq. Int J Curr Eng Technol. 2015;5(3).
  • Oncul O, Ulkur E, Acar A, Turhan V, Yeniz E, Karacaer Z et al. Prospective analysis of nosocomial infections in a burn care unit, Turkey. Indian J Med Res. 2009; 130(6):758–64.
  • Kerr KG, Snelling AM. Pseudomonas aeruginosa: a formidable and ever-present adversary. J Hosp Infect. 2009;73(4):338–44.
  • Azimi L, Motevallian A, Namvar AE, Asghari B, Lari AR. Nosocomial infections in burned patients in Motahari Hospital, Tehran, Iran. Dermatol Res Pract. 2011;10:1155.
  • Lari AR, Alaghehbandan R. Nosocomial infections in an Iranian burn care center. Burns. 2000; 26(8):737–40.
  • Estahbanati H, Kashani P, Ghanaatpished F. Frequency of Pseudomonas aeruginosa serotypes in burn wound infections and their resistance to antibiotics. Burns. 2002;28:340–8.
  • Song W, Man LK, Kang HJ, Shin DH, Kim DK. Microbiologic aspects of predominant bacteria isolated from the burn patients in Korea. Burns. 2001;27:136–9.
  • Hocquet D, Plésiat P, Dehecq B, Mariotte P, Talon D, Bertrand X et al. Nationwide investigation of extended spectrum β-lactamases, metallo-β-lactamases and extended spectrum oxacillinases produced by ceftazidime resistant Pseudomonas aeruginosa isolates in France. Antimicrob Agents Chemother. 2010;54:3512–5.
  • Hong JS, Kim JO, Lee H, Bae IK, Jeong SH, Lee K. Characteristics of metallo-β-lactamase-producing Pseudomonas aeruginosa in Korea. Infect Chemother. 2015;47(1):33–40.
  • Mathlouthi N, Areig Z, Al Bayssari C, Bakour S, Ali El Salabi A, Ben Gwieri S et al. Emergence of Carbapenem-Resistant Pseudomonas aeruginosa and Acinetobacter baumannii Clinical Isolates Collected from Some Libyan Hospitals. Microbial Drug Resistance. 2015;21(3):335–41.
  • Maatallah M, Cheriaa J, Backhrouf A, Iversen A, Grundmann H, Do T et al. Population structure of Pseudomonas aeruginosa from five Mediterranean countries: evidence for frequent recombination and epidemic occurrence of CC235. PLoS One. 2011;6(10).
  • Rojo-Bezares B, Cavalié L, Dubois D, Oswald E, Torres C, Sáenz Y. Characterization of carbapenem resistance mechanisms and integrons in Pseudomonas aeruginosa strains from blood samples in a French hospital. J Med Microbiol. 2016;65(4):311–9.
  • Cholley P, Thouverez M, Hocquet D, Van Der Mee-Marquet N, Talon D, Bertrand X. Most multidrug-resistant Pseudomonas aeruginosa isolates from hospitals in eastern france belong to a few clonal types. J. Clin. Microbiol. 2011;49(7):2578–2583.
  • Wang J, Zhou JY, Qu TT, Shen P, Wei ZQ, Yu YS et al. Molecular epidemiology and mechanisms of carbapenem resistance in Pseudomonas aeruginosa isolates from Chinese hospitals. Int J Antimicrob Agents. 2010;35:486–491.
  • Ocampo-Sosa AA, Cabot G, Rodríguez C, Roman E, Tubau F, Macia MD et al. Alterations of OprD in carbapenem-intermediate and susceptiblestrains of Pseudomonas aeruginosa isolated from patients with bacteremia in a Spanish multicenter study. Antimicrob Agents Chemother. 2012;56:1703–1713.
  • Hardalo C, Edberg SC. Pseudomonas aeruginosa: assessment of risk from drinking water. Crit Rev Microbiol. 1997;23(1):47–75.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.