SERPINE1 as a cancer-promoting gene in gastric adenocarcinoma: facilitates tumour cell proliferation, migration, and invasion by regulating EMT

References

• Ajani JA, Lee J, Sano T, Janjigian YY, Fan D, Song S. Gastric adenocarcinoma. Nat Rev Dis Primers. 2017;3:17036.
   PubMed Web of Science ®Google Scholar
• Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, et al. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 2015;136:E359–386.
   PubMed Web of Science ®Google Scholar
• Saika K, Sobue T. [Cancer statistics in the world]. Gan to Kagaku Ryoho. Can Chemother. 2013;40:2475–2480.
   PubMedGoogle Scholar
• Lei Y, Zheng R, Wang N, Yuan Y, Liu S, Li H, et al. Incidence and mortality of stomach cancer in China, 2014. Chinese J Cancer Res. 2019;31:135–143.
   PubMed Web of Science ®Google Scholar
• Matsumoto S, Yoshida Y. Efficacy of endoscopic screening in an isolated island: a case-control study. Indian J Gastroenterol. 2014;33:46–49.
   PubMedGoogle Scholar
• Song Z, Wu Y, Yang J, Yang D, Fang X. Progress in the treatment of advanced gastric cancer. Tumour Biol. 2017;39:101042831771462.
   Google Scholar
• Janmaat VT, Steyerberg EW, van der Gaast A, Mathijssen RH, Bruno MJ, Peppelenbosch MP, et al. Palliative chemotherapy and targeted therapies for esophageal and gastroesophageal junction cancer. Cochrane Database Syst Rev. 2017;11:Cd004063.
   PubMed Web of Science ®Google Scholar
• Yoo C, Park YS. Companion diagnostics for the targeted therapy of gastric cancer. World J Gastroenterol. 2015;21:10948–10955.
   PubMed Web of Science ®Google Scholar
• Pavon MA, Arroyo-Solera I, Céspedes MV, Casanova I, León X, Mangues R, et al. uPA/uPAR and SERPINE1 in head and neck cancer: role in tumor resistance, metastasis, prognosis and therapy. Oncotarget. 2016;7:57351–57366.
   PubMedGoogle Scholar
• Pavon MA, Arroyo-Solera I, Téllez-Gabriel M, León X, Virós D, López M, et al. Enhanced cell migration and apoptosis resistance may underlie the association between high SERPINE1 expression and poor outcome in head and neck carcinoma patients. Oncotarget. 2015;6:29016–29033.
   PubMedGoogle Scholar
• Arroyo-Solera I, Pavón MÁ, León X, López M, Gallardo A, Céspedes MV, et al. Effect of serpinE1 overexpression on the primary tumor and lymph node, and lung metastases in head and neck squamous cell carcinoma. Head Neck. 2019;41:429–439.
   PubMed Web of Science ®Google Scholar
• Yang K, Zhang S, Zhang D, Tao Q, Zhang T, Liu G, et al. Identification of SERPINE1, PLAU and ACTA1 as biomarkers of head and neck squamous cell carcinoma based on integrated bioinformatics analysis. Int J Clin Oncol. 2019;24:1030-1041.
   Google Scholar
• Dhanda J, Triantafyllou A, Liloglou T, Kalirai H, Lloyd B, Hanlon R, et al. SERPINE1 and SMA expression at the invasive front predict extracapsular spread and survival in oral squamous cell carcinoma. Br J Cancer. 2014;111:2114–2121.
   PubMed Web of Science ®Google Scholar
• Klein RM, Bernstein D, Higgins SP, Higgins CE, Higgins PJ. SERPINE1 expression discriminates site-specific metastasis in human melanoma. Exp Dermatol. 2012;21:551–554.
   PubMed Web of Science ®Google Scholar
• Klimczak-Bitner AA, Kordek R, Bitner J, Musiał J, Szemraj J. Expression of MMP9, SERPINE1 and miR-134 as prognostic factors in esophageal cancer. Oncol Lett. 2016;12:4133.
   PubMed Web of Science ®Google Scholar
• Zhang G, Gomes-Giacoia E, Dai Y, Lawton A, Miyake M, Furuya H, et al. Validation and clinicopathologic associations of a urine-based bladder cancer biomarker signature. Diagn Pathol. 2014;9:1–10.
   PubMed Web of Science ®Google Scholar
• Li X, Dong P, Wei W, Jiang L, Guo S, Huang C, et al. Overexpression of CEP72 promotes bladder urothelial carcinoma cell aggressiveness via epigenetic CREB-mediated induction of SERPINE1. Am J Pathol. 2019;189:1284–1297.
   PubMed Web of Science ®Google Scholar
• Lin X, Lin B-W, Chen X-L, Zhang B-L, Xiao X-J, Shi J-S, et al. PAI-1/PIAS3/Stat3/miR-34a forms a positive feedback loop to promote EMT-mediated metastasis through Stat3 signaling in Non-small cell lung cancer. Biochem Biophys Res Commun. 2017;493:1464–1470.
   PubMed Web of Science ®Google Scholar
• Mazzoccoli G, Pazienza V, Panza A, Valvano MR, Benegiamo G, Vinciguerra M, et al. ARNTL2 and SERPINE1: potential biomarkers for tumor aggressiveness in colorectal cancer. J Cancer Res Clin Oncol. 2012;138:501–511.
   PubMed Web of Science ®Google Scholar
• Wu D-M, Wang S, Wen X, Han X-R, Wang Y-J, Fan S-H, et al. MircoRNA-1275 promotes proliferation, invasion and migration of glioma cells via SERPINE1. J Cell Mol Med. 2018;22:4963–4974.
   PubMed Web of Science ®Google Scholar
• Sang Y, Chen MY, Luo D, Zhang R-H, Wang L, Li M, et al. TEL2 suppresses metastasis by down-regulating SERPINE1 in nasopharyngeal carcinoma. Oncotarget. 2015;6:29240–29253.
   PubMedGoogle Scholar
• Li L, Zhu Z, Zhao Y, Zhang Q, Wu X, Miao B, et al. FN1, SPARC, and SERPINE1 are highly expressed and significantly related to a poor prognosis of gastric adenocarcinoma revealed by microarray and bioinformatics. Sci Rep. 2019;9:7827.
   PubMed Web of Science ®Google Scholar
• Liao P, Li W, Liu R, Teer JK, Xu B, Zhang W, et al. Genome-scale analysis identifies SERPINE1 and SPARC as diagnostic and prognostic biomarkers in gastric cancer. Onco Targets Ther. 2018;11:6969–6980.
   PubMed Web of Science ®Google Scholar
• Ye X, Weinberg RA. Epithelial-mesenchymal plasticity: a central regulator of cancer progression. Trends Cell Biol. 2015;25:675–686.
   PubMed Web of Science ®Google Scholar
• Qureshi R, Arora H, Rizvi MA. EMT in cervical cancer: its role in tumour progression and response to therapy. Cancer Lett. 2015;356:321–331.
   PubMed Web of Science ®Google Scholar
• Xu J, Zhang W, Tang L, Chen W, Guan X. Epithelial-mesenchymal transition induced PAI-1 is associated with prognosis of triple-negative breast cancer patients. Gene. 2018;670:7–14.
   PubMed Web of Science ®Google Scholar
• Thompson EW, Newgreen DF, Tarin D. Carcinoma invasion and metastasis: a role for epithelial-mesenchymal transition? Cancer Res. 2005;65:5991–5995; discussion 5995.
   PubMed Web of Science ®Google Scholar
• Chen T, You Y, Jiang H, Wang ZZ. Epithelial-mesenchymal transition (EMT): a biological process in the development, stem cell differentiation, and tumorigenesis. J Cell Phtsiol. 2017;232:3261–3272.
   Google Scholar
• Serrano-Gomez SJ, Maziveyi M, Alahari SK. Regulation of epithelial-mesenchymal transition through epigenetic and post-translational modifications. Mol Cancer. 2016;15:18.
   PubMed Web of Science ®Google Scholar
• Zou S, Ma C, Yang F, Xu X, Jia J, Liu Z, et al. FBXO31 suppresses gastric cancer EMT by targeting Snail1 for proteasomal degradation. Mol Cancer Res. 2018;16:286–295.
   PubMed Web of Science ®Google Scholar
• Yan K, Tian J, Shi W, Xia H, Zhu Y. LncRNA SNHG6 is associated with poor prognosis of gastric cancer and promotes cell proliferation and EMT through epigenetically silencing p27 and sponging miR-101-3p. Cell Physiol Biochem. 2017;42:999–1012.
   PubMed Web of Science ®Google Scholar
• Pan J-X, Qu F, Wang F-F, Xu J, Mu L-S, Ye L-Y, et al. Aberrant SERPINE1 DNA methylation is involved in carboplatin induced epithelial-mesenchymal transition in epithelial ovarian cancer. Arch Gynecol Obstet. 2017;296:1145–1152.
   PubMed Web of Science ®Google Scholar
• Azimi I, Petersen RM, Thompson EW, Roberts-Thomson SJ, Monteith GR. Hypoxia-induced reactive oxygen species mediate N-cadherin and SERPINE1 expression, EGFR signalling and motility in MDA-MB-468 breast cancer cells. Sci Rep. 2017;7:15140.
   PubMed Web of Science ®Google Scholar