Effect of a “handshake” stewardship program versus a formulary restriction policy on High-End antibiotic use, expenditure, antibiotic resistance, and patient outcome

References

• Centers for Disease Control and Prevention. Antibiotic resistance threats in the United States. Atlanta, GA: CDC; 2013.
   Google Scholar
• The White House. 2014. National strategy for combating antibiotic- resistant bacteria. The White House, Washington, DC. Available from: https://www.whitehouse.gov/sites/default/files/docs/carb_national_strategy.pdf.
   Google Scholar
• Chamoun K, Farah M, Araj G, Daoud Z, Moghnieh R, Salameh P, Saade D, Mokhbat J, Abboud E, Hamze M, et al. Surveillance of antimicrobial resistance in Lebanese hospitals: retrospective nationwide compiled data. Int J Infect Dis. 2016;46:64–70.
   PubMed Web of Science ®Google Scholar
• Moghnieh R, Araj GF, Awad L, Daoud Z, Mokhbat JE, Jisr T, Abdallah D, Azar N, Irani-Hakimeh N, Balkis MM, et al. A compilation of antimicrobial susceptibility data from a network of 13 Lebanese hospitals reflecting the national situation during 2015–2016. Antimicrob Resist Infect Control. 2019;8(1):41.
   PubMedGoogle Scholar
• Araj GF, Avedissian AZ, Ayyash NS. A reflection on bacterial resistance to antimicrobial agents at a major tertiary care center in Lebanon over a decade. J Med Liban. 2012;103(368):1.
   Google Scholar
• Moghnieh R, Siblani L, Ghadban D, El Mchad H, Zeineddine R, Abdallah D, Ziade F, Sinno L, Kiwan O, Kerbaj F, et al. Extensively drug-resistant Acinetobacter baumannii in a Lebanese intensive care unit: risk factors for acquisition and determination of a colonization score. J Hosp Infect. 2016;92(1):47–53.
   PubMed Web of Science ®Google Scholar
• Moghnieh RA, Kanafani ZA, Tabaja HZ, Sharara SL, Awad LS, Kanj SS. Epidemiology of common resistant bacterial pathogens in the countries of the Arab League. Lancet Infect Dis. 2018;18(12):e379–94.
   PubMed Web of Science ®Google Scholar
• Kanafani ZA, Kmeid J, Nawar T, Assaf SM, Zahreddine N, Kanj SS. Retrospective case series of infections caused by carbapenem-resistant Enterobacteriaceae at a tertiary care centre in Lebanon. Int J Antimicrob Agents. 2016;47(5):415–6.
   PubMed Web of Science ®Google Scholar
• Borg MA, Zarb P, Ferech M, Goossens H, on behalf of the ARMed Project Group. Antibiotic consumption in southern and eastern mediterranean hospitals: results from the ARMed project. J Antimicrob Chemother. 2008;62(4):830–836.
   PubMed Web of Science ®Google Scholar
• Iskandar K, Hanna PA, Salameh P, Raad EB. Antibiotic consumption in non-teaching Lebanese hospitals: a cross-sectional study. J Infect Public Heal. 2016; 9(5):618–25.
   PubMed Web of Science ®Google Scholar
• Allouch A, Sabbah H, Samara H, Sabbah S, Droubi N, Sabbah I. Antibiotic use, cost, and consumption in tertiary hospitals in Lebanon: a comparative study before and after an implementation of antibiotic-restriction program (ARP). BJMMR. 2016; 12(3):1–15.
   Google Scholar
• Karanika S, Paudel S, Grigoras C, Kalbasi A, Mylonakis E. Systematic review and meta-analysis of clinical and economic outcomes from the implementation of hospital-based antimicrobial stewardship programs. Antimicrob Agents Chemother. 2016; 60(8):4840–52.
   PubMed Web of Science ®Google Scholar
• Nathwani D, Varghese D, Stephens J, Ansari W, Martin S, Charbonneau C. Value of hospital antimicrobial stewardship programs [ASPs]: a systematic review. Antimicrob Resist Infect Control. 2019;8(1):35.
   PubMedGoogle Scholar
• Moghnieh R, Sakr NY, Kanj SS, Musharrafieh U, Husni R, Jradeh M, et al. The lebanese society for infectious diseases and clinical microbiology (LSIDCM) guidelines for adult community-acquired pneumonia (CAP) in Lebanon. J Med Liban. 2014; 103(1006):1–8.
   Google Scholar
• Husni R, Atoui R, Choucair J, Moghnieh R, Mokhbat J, Tabbarah Z, et al. The Lebanese Society of Infectious Diseases and Clinical Microbiology: Guidelines for the treatment of urinary tract infections. LMJ. 2017; 65(4):208–219.
   Google Scholar
• Haddad N, Kanj SS, Awad LS, Abdallah DI, Moghnieh RA. The 2018 Lebanese Society of Infectious Diseases and Clinical Microbiology Guidelines for the use of antimicrobial therapy in complicated intra-abdominal infections in the era of antimicrobial resistance. BMC Infect Dis. 2019;19(1):293.
   PubMedGoogle Scholar
• Moghnieh R, Kanafani ZA, Abi Hanna P, Matar MJ, Mokhbat J, Jradeh M, et al. 2016 lebanese society of infectious diseases and clinical microbiology guidelines on the management of febrile neutropenia in adult cancer patients in the era of growing antimicrobial resistance. J Med Liban. 2017;65(2):63–82.
   Google Scholar
• Awad L, Abdallah D, Mugharbil A, Jisr T, Droubi N, El Rajab N, Moghnieh R. An antibiotic stewardship exercise in the ICU: building a treatment algorithm for the management of ventilator-associated pneumonia based on local epidemiology and the 2016 Infectious Diseases Society of America/American Thoracic Society guidelines. IDR. 2018; 11:17–28.
   Google Scholar
• Awad L, Tamim H, Abdallah D, Salameh M, Mugharbil A, Jisr T, et al. Correlation between antifungal consumption and the distribution of Candida species in different hospital departments of a Lebanese medical Centre. BMC Infect Dis. 2018;18(1):589.
   PubMedGoogle Scholar
• WHO Collaborating Centre for Drug Statistics Methodology. Guidelines for ATC classification and DDD assignment 2018. Oslo, Norway: World Health Organization; 2017.
   Google Scholar
• Brotherton AL. Metrics of antimicrobial stewardship programs. Med Clin N Am 102. 2018; 102 (5):965–976.
   PubMed Web of Science ®Google Scholar
• CLSI. Performance standards for antimicrobial susceptibility testing; twenty-eighth informational supplement. In: CLSI document M100-S28. Wayne, PA: Clinical and Laboratory Standards Institute; 2018.
   Google Scholar
• Moon HW, Ko YJ, Park S, Hur M, Yun YM. Analysis of community-and hospital-acquired bacteraemia during a recent 5-year period. J Med Microbiol. 2014;63(3):421–6.
   PubMedGoogle Scholar
• CDC. Core elements of hospital antibiotic stewardship programs. Atlanta, GA: US Department of Health and Human Services, CDC; 2014. Available from: http://www.cdc.gov/getsmart/healthcare/implementation/core-elements.html.
   Google Scholar
• MacBrayne CE, Williams MC, Levek C, Child J, Pearce K, Birkholz M, et al. Sustainability of handshake stewardship: extending a hand is effective years later. Clin Infect Dis. 2019; pii: ciz650. https://doi.org/10.1093/cid/ciz650 [Epub ahead of print]
   Web of Science ®Google Scholar
• Moghnieh R, Estaitieh N, Mugharbil A, Jisr T, Abdallah DI, Ziade F, Sinno L, Ibrahim A. Third generation cephalosporin resistant Enterobacteriaceae and multidrug resistant gram-negative bacteria causing bacteremia in febrile neutropenia adult cancer patients in Lebanon, broad spectrum antibiotics use as a major risk factor, and correlation with poor prognosis. Front Cell Infect Microbiol. 2015; 5:11.
   PubMed Web of Science ®Google Scholar
• El-Hajj E, Mrad C, Bou-Assi T, Haddad A, Anouty Z, Jurjus A, et al. Prevalence and risk factors of extended Spectrum Beta lactamase organisms in community-acquired urinary tract infections in Lebanon: a case control study. Euro Mediterranean Biomed J. 2016;11:148–56.
   Google Scholar
• Bassetti M, Carnelutti A, Peghin M. Patient specific risk stratification for antimicrobial resistance and possible treatment strategies in gram-negative bacterial infections. Expert Rev anti Infect Ther. 2017;15(1):55–65.
   PubMed Web of Science ®Google Scholar
• Park SH. Third-generation cephalosporin resistance in gram-negative bacteria in the community: a growing public health concern. Korean J Intern Med. 2014;29(1):27.
   PubMed Web of Science ®Google Scholar
• Harris PNA, Tambyah PA, Lye DC, Mo Y, Lee TH, Yilmaz M, et al. Effect of piperacillin-tazobactam vs meropenem on 30-day mortality for patients with E coli or Klebsiella pneumoniae bloodstream infection and ceftriaxone resistance: a randomized clinical trial. JAMA. 2018;320(10):984–94.
   PubMed Web of Science ®Google Scholar
• Prevel R, Berdaï D, Boyer A. Antibiotics for ceftriaxone-resistant Gram-negative bacterial bloodstream infections. JAMA. 2019;321(6):613.
   PubMedGoogle Scholar
• Sfeir MM. Post-MERINO trial: Any role for piperacillin-tazobactam in treating bloodstream infections caused by extended-spectrum beta-lactamase producing Enterobacteriaceae? Int J Antimicrob Agents. 2019;53(5):557–558.
   PubMed Web of Science ®Google Scholar
• Gutierrez-Gutiérrez B, Rodríguez-Baño J. Current options for the treatment of infections due to extended-spectrum beta-lactamase-producing Enterobacteriaceae in different groups of patients. Clin Microbiol Infect. 2019; 25(8):932–942.
   PubMed Web of Science ®Google Scholar
• Bertollo LG, Lutkemeyer DS, Levin AS. Are antimicrobial stewardship programs effective strategies for preventing antibiotic resistance? A systematic review. Am J Infect Control. 2018;46(7):824–36.
   PubMed Web of Science ®Google Scholar
• Hwang H, Kim B. Impact of an infectious diseases specialist-led antimicrobial stewardship programmes on antibiotic use and antimicrobial resistance in a large Korean hospital. Sci Rep. 2018;8(1):14757.
   PubMedGoogle Scholar
• Schwaber MJ, De-Medina T, Carmeli Y. Epidemiological interpretation of antibiotic resistance studies–what are we missing. ?Nat Rev Microbiol. 2004;2(12):979–983.
   PubMed Web of Science ®Google Scholar
• Schechner V, Temkin E, Harbarth S, Carmeli Y, Schwaber MJ. Epidemiological interpretation of studies examining the effect of antibiotic usage on resistance. Clin Microbiol Rev. 2013;26(2):289–307.
   PubMed Web of Science ®Google Scholar
• Tacconelli E, Carrara E, Savoldi A, Harbarth S, Mendelson M, Monnet DL, Pulcini C, Kahlmeter G, Kluytmans J, Carmeli Y, et al. Discovery, research, and development of new antibiotics: the WHO priority list of antibiotic-resistant bacteria and tuberculosis. Lancet Infect Dis. 2018;18(3):318–27.
   PubMed Web of Science ®Google Scholar
• Hurst AL, Child J, Pearce K, Palmer C, Todd JK, Parker SK. Handshake stewardship. Ped Infect Dis J. 2016;35(10):1104–10.
   PubMed Web of Science ®Google Scholar
• Baker DW, Hyun D, Neuhauser MM, Bhatt J, Srinivasan A. Leading Practices in Antimicrobial Stewardship: Conference Summary. Jt Comm J Qual Patient Saf. 2019; 45(7):517–523.
   PubMed Web of Science ®Google Scholar
• Cole KA, Rivard KR, Dumkow LE. Antimicrobial Stewardship Interventions to Combat Antibiotic Resistance: an Update on Targeted Strategies. Curr Infect Dis Rep. 2019;21(10):33.
   PubMed Web of Science ®Google Scholar
• Schweitzer VA, van Heijl I, van Werkhoven CH, Islam J, Hendriks-Spoor KD, Bielicki J, Bonten MJM, Walker AS, Llewelyn MJ, Harbarth S, et al. The quality of studies evaluating antimicrobial stewardship interventions: a systematic review. Clin Microbiol Infect. 2019; 25(5):555–561.
   PubMed Web of Science ®Google Scholar