Mechanisms and applications of ferroptosis-associated regulators in cancer therapy and drug resistance

References

• Dixon SJ, Lemberg KM, Lamprecht MR, et al. Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell. 2012;149(5):1060–1072.
   PubMed Web of Science ®Google Scholar
• Gan B. Mitochondrial regulation of ferroptosis. J Cell Biol. 2021;220(9):e202105043.
   PubMed Web of Science ®Google Scholar
• Zuo YB, Zhang YF, Zhang R, et al. Ferroptosis in cancer progression: role of noncoding RNAs. Int J Biol Sci. 2022;18(5):1829–1843.
   PubMed Web of Science ®Google Scholar
• Ebrahimi N, Adelian S, Shakerian S, et al. Crosstalk between ferroptosis and the epithelial-mesenchymal transition: implications for inflammation and cancer therapy. Cytokine Growth Factor Rev. 2022;64:33–45.
   PubMed Web of Science ®Google Scholar
• He J, Li Z, Xia P, et al. Ferroptosis and ferritinophagy in diabetes complications. Mol Metab. 2022;60:101470.
   PubMed Web of Science ®Google Scholar
• Zhou ZD, Tan EK. Iron regulatory protein (IRP)-iron responsive element (IRE) signaling pathway in human neurodegenerative diseases. Mol Neurodegener. 2017;12(1):75.
   PubMedGoogle Scholar
• Bogdan AR, Miyazawa M, Hashimoto K, et al. Regulators of iron homeostasis: new players in metabolism, cell death, and disease. Trends Biochem Sci. 2016;41(3):274–286.
   PubMed Web of Science ®Google Scholar
• Li B, Yang L, Peng X, et al. Emerging mechanisms and applications of ferroptosis in the treatment of resistant cancers. Biomed Pharmacother. 2020;130:110710.
   PubMed Web of Science ®Google Scholar
• Richardson DR. Mysteries of the transferrin-transferrin receptor 1 interaction uncovered. Cell. 2004;116(4):483–485.
   PubMed Web of Science ®Google Scholar
• Ohgami RS, Campagna DR, Greer EL, et al. Identification of a ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells. Nat Genet. 2005;37(11):1264–1269.
   PubMed Web of Science ®Google Scholar
• Zheng H, Jiang J, Xu S, et al. Nanoparticle-induced ferroptosis: detection methods, mechanisms and applications. Nanoscale. 2021;13(4):2266–2285.
   PubMed Web of Science ®Google Scholar
• Qin Y, Qiao Y, Wang D, et al. Ferritinophagy and ferroptosis in cardiovascular disease: mechanisms and potential applications. Biomed Pharmacother. 2021;141:111872.
   PubMed Web of Science ®Google Scholar
• Nemeth E, Ganz T. Hepcidin-Ferroportin interaction controls systemic iron homeostasis. IJMS. 2021;22(12):6493.
   Google Scholar
• Shan Z, Wei Z, Shaikh ZA. Suppression of ferroportin expression by cadmium stimulates proliferation, EMT, and migration in triple-negative breast cancer cells. Toxicol Appl Pharmacol. 2018;356:36–43.
   PubMed Web of Science ®Google Scholar
• Gao M, Yi J, Zhu J, et al. Role of mitochondria in ferroptosis. Mol Cell. 2019;73(2):354–363.e3. e353.
   PubMed Web of Science ®Google Scholar
• Yang WS, Stockwell BR. Synthetic lethal screening identifies compounds activating iron-dependent, nonapoptotic cell death in oncogenic-RAS-harboring cancer cells. Chem Biol. 2008;15(3):234–245.
   PubMedGoogle Scholar
• Turcu AL, Versini A, Khene N, et al. DMT1 inhibitors kill cancer stem cells by blocking lysosomal iron translocation. Chemistry. 2020;26(33):7369–7373.
   PubMed Web of Science ®Google Scholar
• Golbashirzadeh M, Heidari HR, Khosroushahi AY. Molecular mechanisms of reactive oxygen species in regulated cell deaths: impact of ferroptosis in cancer therapy. Gene Reports. 2022;27:101614.
   Web of Science ®Google Scholar
• Hou W, Xie Y, Song X, et al. Autophagy promotes ferroptosis by degradation of ferritin. Autophagy. 2016;12(8):1425–1428.
   PubMed Web of Science ®Google Scholar
• Mancias JD, Wang X, Gygi SP, et al. Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy. Nature. 2014;509(7498):105–109.
   PubMed Web of Science ®Google Scholar
• Latunde-Dada GO. Ferroptosis: role of lipid peroxidation, iron and ferritinophagy. Biochim Biophys Acta Gen Subj. 2017;1861(8):1893–1900.
   PubMed Web of Science ®Google Scholar
• Li N, Wang W, Zhou H, et al. Ferritinophagy-mediated ferroptosis is involved in sepsis-induced cardiac injury. Free Radic Biol Med. 2020;160:303–318.
   PubMed Web of Science ®Google Scholar
• Zhang Z, Yao Z, Wang L, et al. Activation of ferritinophagy is required for the RNA-binding protein ELAVL1/HuR to regulate ferroptosis in hepatic stellate cells. Autophagy. 2018;14(12):2083–2103.
   PubMed Web of Science ®Google Scholar
• Hishikawa D, Shindou H, Kobayashi S, et al. Discovery of a lysophospholipid acyltransferase family essential for membrane asymmetry and diversity. Proc Natl Acad Sci U S A. 2008;105(8):2830–2835.
   PubMed Web of Science ®Google Scholar
• Dixon SJ, Winter GE, Musavi LS, et al. Human haploid cell genetics reveals roles for lipid metabolism genes in nonapoptotic cell death. ACS Chem Biol. 2015;10(7):1604–1609.
   PubMed Web of Science ®Google Scholar
• Tousignant KD, Rockstroh A, Poad BLJ, et al. Therapy-induced lipid uptake and remodeling underpin ferroptosis hypersensitivity in prostate cancer. Cancer Metab. 2020;8:11.
   PubMed Web of Science ®Google Scholar
• Kagan VE, Mao G, Qu F, et al. Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis. Nat Chem Biol. 2017;13(1):81–90.
   PubMed Web of Science ®Google Scholar
• Magtanong L, Ko PJ, To M, et al. Exogenous monounsaturated fatty acids promote a Ferroptosis-Resistant cell state. Cell Chem Biol. 2019;26(3):420–432.e429.
   PubMed Web of Science ®Google Scholar
• Zou Y, Li H, Graham ET, et al. Cytochrome P450 oxidoreductase contributes to phospholipid peroxidation in ferroptosis. Nat Chem Biol. 2020;16(3):302–309.
   PubMed Web of Science ®Google Scholar
• Probst L, Dächert J, Schenk B, et al. Lipoxygenase inhibitors protect acute lymphoblastic leukemia cells from ferroptotic cell death. Biochem Pharmacol. 2017;140:41–52.
   PubMed Web of Science ®Google Scholar
• Ates G, Goldberg J, Currais A, et al. CMS121, a fatty acid synthase inhibitor, protects against excess lipid peroxidation and inflammation and alleviates cognitive loss in a transgenic mouse model of alzheimer’s disease. Redox Biol. 2020;36:101648.
   PubMed Web of Science ®Google Scholar
• Yan B, Ai Y, Sun Q, et al. Membrane damage during ferroptosis is caused by oxidation of phospholipids catalyzed by the oxidoreductases POR and CYB5R1. Mol Cell. 2021;81(2):355–369.e10. e310.
   PubMed Web of Science ®Google Scholar
• Zhang LL, Tang RJ, Yang YJ. The underlying pathological mechanism of ferroptosis in the development of cardiovascular disease. Front Cardiovasc Med. 2022;9:964034.
   PubMed Web of Science ®Google Scholar
• Rishi G, Huang G, Subramaniam VN. Cancer: the role of iron and ferroptosis. Int J Biochem Cell Biol. 2021;141:106094.
   PubMed Web of Science ®Google Scholar
• Sui S, Xu S, Pang D. Emerging role of ferroptosis in breast cancer: new dawn for overcoming tumor progression. Pharmacol Ther. 2022;232:107992.
   PubMed Web of Science ®Google Scholar
• Seibt TM, Proneth B, Conrad M. Role of GPX4 in ferroptosis and its pharmacological implication. Free Radic Biol Med. 2019;133:144–152.
   PubMed Web of Science ®Google Scholar
• Yang WS, SriRamaratnam R, Welsch ME, et al. Regulation of ferroptotic cancer cell death by GPX4. Cell. 2014;156(1-2):317–331.
   PubMed Web of Science ®Google Scholar
• Hsieh P-L, Chao S-C, Chu P-M, et al. Regulation of ferroptosis by Non-Coding RNAs in head and neck cancers. IJMS. 2022;23(6):3142.
   Google Scholar
• Yang WS, Stockwell BR. Ferroptosis: death by lipid peroxidation. Trends Cell Biol. 2016;26(3):165–176.
   PubMed Web of Science ®Google Scholar
• Tu H, Tang LJ, Luo XJ, et al. Insights into the novel function of system Xc- in regulated cell death. Eur Rev Med Pharmacol Sci. 2021;25(3):1650–1662.
   PubMed Web of Science ®Google Scholar
• Liu X, Zhang Y, Zhuang L, et al. NADPH debt drives redox bankruptcy: SLC7A11/xCT-mediated cystine uptake as a double-edged sword in cellular redox regulation. Genes Dis. 2021;8(6):731–745.
   PubMed Web of Science ®Google Scholar
• Su Y, Zhao B, Zhou L, et al. Ferroptosis, a novel pharmacological mechanism of anti-cancer drugs. Cancer Lett. 2020;483:127–136.
   PubMed Web of Science ®Google Scholar
• Liu J, Xia X, Huang P. xCT: a critical molecule that links cancer metabolism to redox signaling. Mol Ther. 2020;28(11):2358–2366.
   PubMed Web of Science ®Google Scholar
• Zhang W, Sun Y, Bai L, et al. RBMS1 regulates lung cancer ferroptosis through translational control of SLC7A11. J Clin Invest. 2021;131(22):e152067.
   PubMed Web of Science ®Google Scholar
• Liu J, Liu M, Zhang H, et al. Exploring cysteine regulation in cancer cell survival with a highly specific "lock and key" fluorescent probe for cysteine. Chem Sci. 2019;10(43):10065–10071.
   PubMed Web of Science ®Google Scholar
• Lei P, Bai T, Sun Y. Mechanisms of ferroptosis and relations with regulated cell death: a review. Front Physiol. 2019;10:139.
   PubMed Web of Science ®Google Scholar
• Wenzel SE, Tyurina YY, Zhao J, et al. PEBP1 wardens ferroptosis by enabling lipoxygenase generation of lipid death signals. Cell. 2017;171(3):628–641.e26. e626.
   PubMed Web of Science ®Google Scholar
• Shimada K, Hayano M, Pagano NC, et al. Cell-Line selectivity improves the predictive power of pharmacogenomic analyses and helps identify NADPH as biomarker for ferroptosis sensitivity. Cell Chem Biol. 2016;23(2):225–235.
   PubMed Web of Science ®Google Scholar
• Badgley MA, Kremer DM, Maurer HC, et al. Cysteine depletion induces pancreatic tumor ferroptosis in mice. Science. 2020;368(6486):85–89.
   PubMed Web of Science ®Google Scholar
• Mbah NE, Lyssiotis CA. Metabolic regulation of ferroptosis in the tumor microenvironment. J Biol Chem. 2022;298(3):101617.
   PubMed Web of Science ®Google Scholar
• Kahroba H, Shirmohamadi M, Hejazi MS, et al. The role of Nrf2 signaling in cancer stem cells: from stemness and self-renewal to tumorigenesis and chemoresistance. Life Sci. 2019;239:116986.
   PubMed Web of Science ®Google Scholar
• Sarutipaiboon I, Settasatian N, Komanasin N, et al. Association of genetic variations in NRF2, NQO1, HMOX1, and MT with severity of coronary artery disease and related risk factors. Cardiovasc Toxicol. 2020;20(2):176–189.
   PubMed Web of Science ®Google Scholar
• Zhang DD, Lo SC, Cross JV, et al. Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex. Mol Cell Biol. 2004;24(24):10941–10953.
   PubMed Web of Science ®Google Scholar
• Taguchi K, Yamamoto M. The KEAP1-NRF2 system in cancer. Front Oncol. 2017;7:85.
   PubMed Web of Science ®Google Scholar
• Lien EC, Lyssiotis CA, Juvekar A, et al. Glutathione biosynthesis is a metabolic vulnerability in PI(3)K/akt-driven breast cancer. Nat Cell Biol. 2016;18(5):572–578.
   PubMed Web of Science ®Google Scholar
• Chen D, Tavana O, Chu B, et al. NRF2 is a major target of ARF in p53-Independent tumor suppression. Mol Cell. 2017;68(1):224–232.e4. e224.
   PubMed Web of Science ®Google Scholar
• Lei G, Mao C, Yan Y, et al. Ferroptosis, radiotherapy, and combination therapeutic strategies. Protein Cell. 2021;12(11):836–857.
   PubMed Web of Science ®Google Scholar
• Kang R, Kroemer G, Tang D. The tumor suppressor protein p53 and the ferroptosis network. Free Radic Biol Med. 2019;133:162–168.
   PubMed Web of Science ®Google Scholar
• Wang Y, Zhang Z, Sun W, et al. Ferroptosis in colorectal cancer: potential mechanisms and effective therapeutic targets. Biomed Pharmacother. 2022;153:113524.
   PubMed Web of Science ®Google Scholar
• Kraft VAN, Bezjian CT, Pfeiffer S, et al. GTP cyclohydrolase 1/tetrahydrobiopterin counteract ferroptosis through lipid remodeling. ACS Cent Sci. 2020;6(1):41–53.
   PubMed Web of Science ®Google Scholar
• Hu Q, Wei W, Wu D, et al. Blockade of GCH1/BH4 axis activates ferritinophagy to mitigate the resistance of colorectal cancer to Erastin-Induced ferroptosis. Front Cell Dev Biol. 2022;10:810327.
   PubMed Web of Science ®Google Scholar
• Xie LH, Fefelova N, Pamarthi SH, et al. Molecular mechanisms of ferroptosis and relevance to cardiovascular disease. Cells. 2022;11(17):2726.
   PubMed Web of Science ®Google Scholar
• Gao M, Monian P, Quadri N, et al. Glutaminolysis and transferrin regulate ferroptosis. Mol Cell. 2015;59(2):298–308.
   PubMed Web of Science ®Google Scholar
• Mao C, Liu X, Zhang Y, et al. DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer. Nature. 2021;593(7860):586–590.
   PubMed Web of Science ®Google Scholar
• Toyokuni S, Ito F, Yamashita K, et al. Iron and thiol redox signaling in cancer: an exquisite balance to escape ferroptosis. Free Radic Biol Med. 2017;108:610–626.
   PubMed Web of Science ®Google Scholar
• Freitas I, Boncompagni E, Vaccarone R, et al. Iron accumulation in mammary tumor suggests a tug of war between tumor and host for the microelement. Anticancer Res. 2007;27(5a):3059–3065.
   PubMed Web of Science ®Google Scholar
• Candelaria PV, Leoh LS, Penichet ML, et al. Antibodies targeting the transferrin receptor 1 (TfR1) as direct anti-cancer agents. Front Immunol. 2021;12:607692.
   PubMed Web of Science ®Google Scholar
• Müller S, Sindikubwabo F, Cañeque T, et al. CD44 regulates epigenetic plasticity by mediating iron endocytosis. Nat Chem. 2020;12(10):929–938.
   PubMed Web of Science ®Google Scholar
• Ma MZ, Chen G, Wang P, et al. Xc- inhibitor sulfasalazine sensitizes colorectal cancer to cisplatin by a GSH-dependent mechanism. Cancer Lett. 2015;368(1):88–96.
   PubMed Web of Science ®Google Scholar
• Chen D, Fan Z, Rauh M, et al. ATF4 promotes angiogenesis and neuronal cell death and confers ferroptosis in a xCT-dependent manner. Oncogene. 2017;36(40):5593–5608.
   PubMed Web of Science ®Google Scholar
• Zhou HH, Chen X, Cai LY, et al. Erastin reverses ABCB1-Mediated docetaxel resistance in ovarian cancer. Front Oncol. 2019;9:1398.
   PubMed Web of Science ®Google Scholar
• Zhang Y, Tan H, Daniels JD, et al. Imidazole ketone erastin induces ferroptosis and slows tumor growth in a mouse lymphoma model. Cell Chem Biol. 2019;26(5):623–633.e9. e629.
   PubMed Web of Science ®Google Scholar
• Shin D, Kim EH, Lee J, et al. Nrf2 inhibition reverses resistance to GPX4 inhibitor-induced ferroptosis in head and neck cancer. Free Radic Biol Med. 2018;129:454–462.
   PubMed Web of Science ®Google Scholar
• Eling N, Reuter L, Hazin J, et al. Identification of artesunate as a specific activator of ferroptosis in pancreatic cancer cells. Oncoscience. 2015;2(5):517–532.
   PubMedGoogle Scholar
• Lin R, Zhang Z, Chen L, et al. Dihydroartemisinin (DHA) induces ferroptosis and causes cell cycle arrest in head and neck carcinoma cells. Cancer Lett. 2016;381(1):165–175.
   PubMed Web of Science ®Google Scholar
• Ma S, Henson ES, Chen Y, et al. Ferroptosis is induced following siramesine and lapatinib treatment of breast cancer cells. Cell Death Dis. 2016;7(7):e2307.
   PubMed Web of Science ®Google Scholar
• Wang Z, Zhou L, Xiong Y, et al. Salinomycin exerts anti-colorectal cancer activity by targeting the β-catenin/T-cell factor complex. Br J Pharmacol. 2019;176(17):3390–3406.
   PubMed Web of Science ®Google Scholar
• Mai TT, Hamaï A, Hienzsch A, et al. Salinomycin kills cancer stem cells by sequestering iron in lysosomes. Nat Chem. 2017;9(10):1025–1033.
   PubMed Web of Science ®Google Scholar
• Kanugula AK, Gollavilli PN, Vasamsetti SB, et al. Statin-induced inhibition of breast cancer proliferation and invasion involves attenuation of iron transport: intermediacy of nitric oxide and antioxidant defence mechanisms. Febs J. 2014;281(16):3719–3738.
   PubMed Web of Science ®Google Scholar
• Sun Y, Berleth N, Wu W, et al. Fin56-induced ferroptosis is supported by autophagy-mediated GPX4 degradation and functions synergistically with mTOR inhibition to kill bladder cancer cells. Cell Death Dis. 2021;12(11):1028.
   PubMed Web of Science ®Google Scholar
• Yang J, Jia Z, Zhang J, et al. Metabolic intervention nanoparticles for Triple-Negative breast cancer therapy via overcoming FSP1-Mediated ferroptosis resistance. Adv Healthc Mater. 2022;11(13):e2102799.
   PubMed Web of Science ®Google Scholar
• Wahl C, Liptay S, Adler G, et al. Sulfasalazine: a potent and specific inhibitor of nuclear factor kappa B. J Clin Invest. 1998;101(5):1163–1174.
   PubMed Web of Science ®Google Scholar
• Houessinon A, François C, Sauzay C, et al. Metallothionein-1 as a biomarker of altered redox metabolism in hepatocellular carcinoma cells exposed to sorafenib. Mol Cancer. 2016;15(1):38.
   PubMedGoogle Scholar
• Yu H, Guo P, Xie X, et al. Ferroptosis, a new form of cell death, and its relationships with tumourous diseases. J Cell Mol Med. 2017;21(4):648–657.
   PubMed Web of Science ®Google Scholar
• Chen L, Li X, Liu L, et al. Erastin sensitizes glioblastoma cells to temozolomide by restraining xCT and cystathionine-γ-lyase function. Oncol Rep. 2015;33(3):1465–1474.
   PubMed Web of Science ®Google Scholar
• Li N, Yi X, He Y, et al. Targeting ferroptosis as a novel approach to alleviate aortic dissection. Int J Biol Sci. 2022;18(10):4118–4134.
   PubMed Web of Science ®Google Scholar
• Sui X, Zhang R, Liu S, et al. RSL3 drives ferroptosis through GPX4 inactivation and ROS production in colorectal cancer. Front Pharmacol. 2018;9:1371.
   PubMed Web of Science ®Google Scholar
• Yang J, Mo J, Dai J, et al. Cetuximab promotes RSL3-induced ferroptosis by suppressing the Nrf2/HO-1 signalling pathway in KRAS mutant colorectal cancer. Cell Death Dis. 2021;12(11):1079.
   PubMed Web of Science ®Google Scholar
• Ye Z, Hu Q, Zhuo Q, et al. Abrogation of ARF6 promotes RSL3-induced ferroptosis and mitigates gemcitabine resistance in pancreatic cancer cells. Am J Cancer Res. 2020;10(4):1182–1193.
   PubMed Web of Science ®Google Scholar
• Greenshields AL, Shepherd TG, Hoskin DW. Contribution of reactive oxygen species to ovarian cancer cell growth arrest and killing by the anti-malarial drug artesunate. Mol Carcinog. 2017;56(1):75–93.
   PubMed Web of Science ®Google Scholar
• Ostenfeld MS, Fehrenbacher N, Høyer-Hansen M, et al. Effective tumor cell death by sigma-2 receptor ligand siramesine involves lysosomal leakage and oxidative stress. Cancer Res. 2005;65(19):8975–8983.
   PubMed Web of Science ®Google Scholar
• Wood ER, Truesdale AT, McDonald OB, et al. A unique structure for epidermal growth factor receptor bound to GW572016 (lapatinib): relationships among protein conformation, inhibitor off-rate, and receptor activity in tumor cells. Cancer Res. 2004;64(18):6652–6659.
   PubMed Web of Science ®Google Scholar
• Antoszczak M. A comprehensive review of salinomycin derivatives as potent anticancer and anti-CSCs agents. Eur J Med Chem. 2019;166:48–64.
   PubMed Web of Science ®Google Scholar
• Marcheggiani F, Cirilli I, Orlando P, et al. Modulation of coenzyme Q(10) content and oxidative status in human dermal fibroblasts using HMG-CoA reductase inhibitor over a broad range of concentrations. From mitohormesis to mitochondrial dysfunction and accelerated aging. Aging (Albany NY). 2019;11(9):2565–2582.
   PubMedGoogle Scholar
• Cramer SL, Saha A, Liu J, et al. Systemic depletion of L-cyst(e)ine with cyst(e)inase increases reactive oxygen species and suppresses tumor growth. Nat Med. 2017;23(1):120–127.
   PubMed Web of Science ®Google Scholar
• Shimada K, Skouta R, Kaplan A, et al. Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis.Nat Chem Biol. 2016;12(7):497–503.
   Google Scholar
• Kim SE, Zhang L, Ma K, et al. Ultrasmall nanoparticles induce ferroptosis in nutrient-deprived cancer cells and suppress tumour growth. Nat Nanotechnol. 2016;11(11):977–985.
   PubMed Web of Science ®Google Scholar
• Chen P, Li X, Zhang R, et al. Combinative treatment of β-elemene and cetuximab is sensitive to KRAS mutant colorectal cancer cells by inducing ferroptosis and inhibiting epithelial-mesenchymal transformation. Theranostics. 2020;10(11):5107–5119.
   PubMed Web of Science ®Google Scholar
• Jomen W, Ohtake T, Akita T, et al. Iron chelator deferasirox inhibits NF-κB activity in hepatoma cells and changes sorafenib-induced programmed cell deaths. Biomed Pharmacother. 2022;153:113363.
   PubMed Web of Science ®Google Scholar
• Koppula P, Lei G, Zhang Y, et al. A targetable CoQ-FSP1 axis drives ferroptosis- and radiation-resistance in KEAP1 inactive lung cancers. Nat Commun. 2022;13(1):2206.
   PubMed Web of Science ®Google Scholar
• Wortmann M, Schneider M, Pircher J, et al. Combined deficiency in glutathione peroxidase 4 and vitamin E causes multiorgan thrombus formation and early death in mice. Circ Res. 2013;113(4):408–417.
   PubMed Web of Science ®Google Scholar
• Ajoolabady A, Aslkhodapasandhokmabad H, Libby P, et al. Ferritinophagy and ferroptosis in the management of metabolic diseases. Trends Endocrinol Metab. 2021;32(7):444–462.
   PubMed Web of Science ®Google Scholar
• Weber S, Parmon A, Kurrle N, et al. The clinical significance of iron overload and iron metabolism in myelodysplastic syndrome and acute myeloid leukemia. Front Immunol. 2020;11:627662.
   PubMed Web of Science ®Google Scholar
• You H, Wang D, Wei L, et al. Deferoxamine inhibits acute lymphoblastic leukemia progression through repression of ROS/HIF-1α, wnt/β-Catenin, and p38MAPK/ERK pathways. J Oncol. 2022;2022:8281267.
   PubMed Web of Science ®Google Scholar
• Cappellini MD, Pattoneri P. Oral iron chelators. Annu Rev Med. 2009;60:25–38.
   PubMed Web of Science ®Google Scholar
• Jin X, Chu Q, Sun L, et al. Phosphoinositide 3 kinase γ plays a critical role in acute kidney injury. Cells. 2022;11(5):772.
   PubMed Web of Science ®Google Scholar
• Bersuker K, Hendricks JM, Li Z, et al. The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis. Nature. 2019;575(7784):688–692.
   PubMed Web of Science ®Google Scholar
• Mishima E, Ito J, Wu Z, et al. A non-canonical vitamin K cycle is a potent ferroptosis suppressor. Nature. 2022;608(7924):778–783.
   PubMed Web of Science ®Google Scholar
• Hinman A, Holst CR, Latham JC, et al. Vitamin E hydroquinone is an endogenous regulator of ferroptosis via redox control of 15-lipoxygenase. PLoS One. 2018;13(8):e0201369.
   PubMed Web of Science ®Google Scholar
• Angeli JPF, Shah R, Pratt DA, et al. Ferroptosis inhibition: mechanisms and opportunities. Trends Pharmacol Sci. 2017;38(5):489–498.
   PubMed Web of Science ®Google Scholar
• Zhang X, Jiang L, Chen H, et al. Resveratrol protected acrolein-induced ferroptosis and insulin secretion dysfunction via ER-stress- related PERK pathway in MIN6 cells. Toxicology. 2022;465:153048.
   PubMed Web of Science ®Google Scholar
• Mansoori B, Mohammadi A, Davudian S, et al. The different mechanisms of cancer drug resistance: a brief review. Adv Pharm Bull. 2017;7(3):339–348.
   PubMed Web of Science ®Google Scholar
• Elgendy SM, Alyammahi SK, Alhamad DW, et al. Ferroptosis: an emerging approach for targeting cancer stem cells and drug resistance. Crit Rev Oncol Hematol. 2020;155:103095.
   PubMed Web of Science ®Google Scholar
• Qiao J, Chen Y, Mi Y, et al. NR5A2 synergizes with NCOA3 to induce breast cancer resistance to BET inhibitor by upregulating NRF2 to attenuate ferroptosis. Biochem Biophys Res Commun. 2020;530(2):402–409.
   PubMed Web of Science ®Google Scholar
• Rodriguez R, Schreiber SL, Conrad M. Persister cancer cells: iron addiction and vulnerability to ferroptosis. Mol Cell. 2022;82(4):728–740.
   PubMed Web of Science ®Google Scholar
• Hangauer MJ, Viswanathan VS, Ryan MJ, et al. Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition. Nature. 2017;551(7679):247–250.
   PubMed Web of Science ®Google Scholar
• Walerych D, Lisek K, Sommaggio R, et al. Proteasome machinery is instrumental in a common gain-of-function program of the p53 missense mutants in cancer. Nat Cell Biol. 2016;18(8):897–909.
   PubMed Web of Science ®Google Scholar
• Sun X, Ou Z, Chen R, et al. Activation of the p62-Keap1-NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells. Hepatology. 2016;63(1):173–184.
   PubMed Web of Science ®Google Scholar
• Pirpour Tazehkand A, Akbarzadeh M, Velaie K, et al. The role of Her2-Nrf2 axis in induction of oxaliplatin resistance in Colon cancer cells. Biomed Pharmacother. 2018;103:755–766.
   PubMed Web of Science ®Google Scholar
• Sun X, Niu X, Chen R, et al. Metallothionein-1G facilitates sorafenib resistance through inhibition of ferroptosis. Hepatology. 2016;64(2):488–500.
   PubMed Web of Science ®Google Scholar
• Huang Y, Dai Z, Barbacioru C, et al. Cystine-glutamate transporter SLC7A11 in cancer chemosensitivity and chemoresistance. Cancer Res. 2005;65(16):7446–7454.
   PubMed Web of Science ®Google Scholar
• Lu J, Holmgren A. The thioredoxin antioxidant system. Free Radic Biol Med. 2014;66:75–87.
   PubMed Web of Science ®Google Scholar
• Zhou W, Fang C, Zhang L, et al. Thioredoxin domain-containing protein 9 (TXNDC9) contributes to oxaliplatin resistance through regulation of autophagy-apoptosis in colorectal adenocarcinoma. Biochem Biophys Res Commun. 2020;524(3):582–588.
   PubMed Web of Science ®Google Scholar