Multiple pharmacological approaches on hydroalcoholic extracts from different parts of Cynoglossum creticum Mill. (Boraginaceae)

References

• Arnold S, Arvanitakis Z, Macauley-Rambach S, Koenig A, Wang H, Ahima R, Craft S, Gandy S, Buettner C, Stoeckel L, et al. 2018. Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums. Nat Rev Neurol. 14(3):168–181.
   PubMed Web of Science ®Google Scholar
• Asibal CF, Glinski JA, Gelbaum LT, Zalkow LH. 1989. Pyrrolizidine alkaloids from Cynoglossum creticum. Synthesis of the pyrrolizidine alkaloids echinatine, rinderine, and analogues. J Nat Prod. 52(1):109–118.
   PubMed Web of Science ®Google Scholar
• Avila J, Llorens-Martín M, Pallas-Bazarra N, Bolós M, Perea JR, Rodríguez-Matellán A, Hernández F. 2017. Cognitive decline in neuronal aging and Alzheimer's disease: role of NMDA receptors and associated proteins. Front Neurosci. 11:626.
   PubMed Web of Science ®Google Scholar
• Bozluolcay M, Andican G, Fırtına S, Erkol G, Konukoglu D. 2016. Inflammatory hypothesis as a link between Alzheimer's disease and diabetes mellitus. Geriatr Gerontol Int. 16(10):1161–1166.
   PubMed Web of Science ®Google Scholar
• Brockmeyer B, Kraus UR, Theobald N. 2015. Accelerated solvent extraction (ASE) for purification and extraction of silicone passive samplers used for the monitoring of organic pollutants. Environ Sci Pollut Res. 22(24):19887–19895.
   PubMed Web of Science ®Google Scholar
• Buchholz T, Melzig MF. 2015. Polyphenolic compounds as pancreatic lipase inhibitors. Planta Med. 81(10):771–783.
   PubMed Web of Science ®Google Scholar
• Cespedes CL, Balbontin C, Avila JG, Dominguez M, Alarcon J, Paz C, Burgos V, Ortiz L, Peñaloza-Castro I, Seigler DS, et al. 2017. Inhibition on cholinesterase and tyrosinase by alkaloids and phenolics from Aristotelia chilensis leaves. Food Chem Toxicol. 109(Pt 2):984–995.
   PubMedGoogle Scholar
• Chen Y, Zhu J, Mo J, Yang H, Jiang X, Lin H, Gu K, Pei Y, Wu L, Tan R, et al. 2018. Synthesis and bioevaluation of new tacrine-cinnamic acid hybrids as cholinesterase inhibitors against Alzheimer’s disease. J Enzyme Inhib Med Chem. 33(1):290–302.
   PubMed Web of Science ®Google Scholar
• Colak N, Primetta AK, Riihinen KR, Jaakola L, Grúz J, Strnad M, Torun H, Ayaz FA. 2017. Phenolic compounds and antioxidant capacity in different-colored and non-pigmented berries of bilberry (Vaccinium myrtillus L.). Food Biosci. 20:67–78.
   Web of Science ®Google Scholar
• Dresler S, Szymczak G, Wójcik M. 2017. Comparison of some secondary metabolite content in the seventeen species of the Boraginaceae family. Pharm Biol. 55(1):691–695.
   PubMedGoogle Scholar
• Elkady AI, Hussein RA, El-Assouli SM. 2016. Harmal extract induces Apoptosis of HCT116 human colon cancer cells, mediated by inhibition of nuclear factor-κB and activator protein-1 signaling pathways and induction of cytoprotective genes. Asian Pac J Cancer Prev. 17(4):1947–1959.
   PubMedGoogle Scholar
• El-Shazly A, Sarg T, Witte L, Wink M. 1996. Pyrrolizidine alkaloids from Cynoglossum creticum. Phytochemistry. 42(4):1217–1221.
   Web of Science ®Google Scholar
• Folch J, Ettcheto M, Busquets O, Sánchez-López E, Castro-Torres R, Verdaguer E, Manzine P, Poor S, García M, Olloquequi J, et al. 2018. The implication of the brain insulin receptor in late onset Alzheimer’s disease dementia. Pharmaceuticals. 11(1):11.
   Web of Science ®Google Scholar
• Gonçalves S, Romano A. 2017. Inhibitory properties of phenolic compounds against enzymes linked with human diseases. Phenolic compounds-biological activity. 99–118.
   Google Scholar
• Gonzalez-Franquesa A, Patti M-E. 2017. Insulin resistance and mitochondrial dysfunction. In: Santulli G, editors. Mitochondrial dynamics in cardiovascular medicine. Cham: Springer; p. 465–520.
   Google Scholar
• Grochowski DM, Uysal S, Aktumsek A, Granica S, Zengin G, Ceylan R, Locatelli M, Tomczyk M. 2017. In vitro enzyme inhibitory properties, antioxidant activities, and phytochemical profile of Potentilla thuringiaca. Phytochem Lett. 20:365–372.
   Web of Science ®Google Scholar
• Gülçin İ, Scozzafava A, Supuran CT, Koksal Z, Turkan F, Çetinkaya S, Bingöl Z, Huyut Z, Alwasel SH. 2016. Rosmarinic acid inhibits some metabolic enzymes including glutathione S-transferase, lactoperoxidase, acetylcholinesterase, butyrylcholinesterase and carbonic anhydrase isoenzymes. J Enzyme Inhib Med Chem. 31(6):1698–1702.
   PubMed Web of Science ®Google Scholar
• Helmstädter A. 2016. Ethnopharmacology in the work of Melville William Hilton-Simpson (1881–1938) – historical analysis and current research opportunities. Die Pharm. 71(6):352–360.
   PubMed Web of Science ®Google Scholar
• Hsu CL, Yen GC. 2008. Phenolic compounds: evidence for inhibitory effects against obesity and their underlying molecular signaling mechanisms. Mol Nutr Food Res. 52(1):53–61.
   PubMed Web of Science ®Google Scholar
• Hu R, Chen N, Yao J, Zhao Q, Zhang F, Li Z-Y, You Q-D, Guo Q-L. 2012. The role of Nrf2 and apoptotic signaling pathways in oroxylin A-mediated responses in HCT-116 colorectal adenocarcinoma cells and xenograft tumors. Anti-Cancer Drugs. 23(6):651–658.
   PubMed Web of Science ®Google Scholar
• Huyut Z, Beydemir Ş, Gülçin İ. 2017. Antioxidant and antiradical properties of selected flavonoids and phenolic compounds. Biochem Res Int. 2017:7616791.
   PubMedGoogle Scholar
• Kim Y-J, Uyama H. 2005. Tyrosinase inhibitors from natural and synthetic sources: structure, inhibition mechanism and perspective for the future. Cell Mol Life Sci. 62(15):1707–1723.
   PubMed Web of Science ®Google Scholar
• Lee SY, Baek N, Nam T-G. 2016. Natural, semisynthetic and synthetic tyrosinase inhibitors. J Enzyme Inhib Med Chem. 31(1):1–13.
   PubMed Web of Science ®Google Scholar
• Limmongkon A, Nopprang P, Chaikeandee P, Somboon T, Wongshaya P, Pilaisangsuree V. 2018. LC-MS/MS profiles and interrelationships between the anti-inflammatory activity, total phenolic content and antioxidant potential of Kalasin 2 cultivar peanut sprout crude extract. Food Chem. 239:569–578.
   PubMed Web of Science ®Google Scholar
• Liu Z, Qi L, Li Y, Zhao X, Sun B. 2017. VEGFR2 regulates endothelial differentiation of colon cancer cells. BMC Cancer. 17(1):593
   PubMedGoogle Scholar
• Llorent-Martínez EJ, Zengin G, Fernández-de Córdova ML, Bender O, Atalay A, Ceylan R, Mollica A, Mocan A, Uysal S, Guler GO. 2017. Traditionally used Lathyrus species: phytochemical composition, antioxidant activity, enzyme inhibitory properties, cytotoxic effects, and in silico studies of L. czeczottianus and L. nissolia. Front Pharmacol. 8:83.
   PubMed Web of Science ®Google Scholar
• Locatelli M, Zengin G, Uysal A, Carradori S, De Luca E, Bellagamba G, Aktumsek A, Lazarova I. 2017. Multicomponent pattern and biological activities of seven Asphodeline taxa: potential sources of natural-functional ingredients for bioactive formulations. J Enzyme Inhib Med Chem. 32(1):60–67.
   PubMed Web of Science ®Google Scholar
• Martinez-Gonzalez AI, Díaz-Sánchez ÁG, Rosa LA, Vargas-Requena CL, Bustos-Jaimes I, Alvarez-Parrilla AE. 2017. Polyphenolic compounds and digestive enzymes: in vitro non-covalent interactions. Molecules. 22(4):669.
   Web of Science ®Google Scholar
• Menghini L, Leporini L, Scanu N, Pintore G, La Rovere R, Di Filippo E, Pietrangelo T, Fulle S. 2011. Effect of phytochemical concentrations on biological activities of cranberry extracts. J Biol Regul Homeostat Agents. 25(1):27–35.
   PubMed Web of Science ®Google Scholar
• Menghini L, Leporini L, Vecchiotti G, Locatelli M, Carradori S, Ferrante C, Zengin G, Recinella L, Chiavaroli A, Leone S, et al. 2018. Crocus sativus L. stigmas and byproducts: qualitative fingerprint, antioxidant potentials and enzyme inhibitory activities. Food Res Int. 109:91–98.
   PubMed Web of Science ®Google Scholar
• Mocan A, Diuzheva A, Carradori S, Andruch V, Massafra C, Moldovan C, Sisea C, Petzer JP, Petzer A, Zara S. 2018. Development of novel techniques to extract phenolic compounds from Romanian cultivars of Prunus domestica L. and their biological properties. Food Chem Toxicol. 119:189–198.
   Web of Science ®Google Scholar
• Mollica A, Zengin G, Stefanucci A, Ferrante C, Menghini L, Orlando G, Brunetti L, Locatelli M, Dimmito MP, Novellino E, et al. 2018. Nutraceutical potential of Corylus avellana daily supplements for obesity and related dysmetabolism. J Funct Foods. 47:562–574.
   Web of Science ®Google Scholar
• Newman DJ, Cragg GM. 2012. Natural products as sources of new drugs over the 30 years from 1981 to 2010. J Nat Prod. 75(3):311–335.
   PubMed Web of Science ®Google Scholar
• Palmese MT, Manganelli REU, Tomei PE. 2001. An ethno-pharmacobotanical survey in the Sarrabus district (south-east Sardinia). Fitoterapia. 72(6):619–643.
   PubMed Web of Science ®Google Scholar
• Picot MC, Zengin G, Mollica A, Stefanucci A, Carradori S, Mahomoodally M. 2017. In vitro and in silico studies of mangiferin from Aphloia theiformis on key enzymes linked to diabetes type 2 and associated complications. Med Chem. 13(7):633–640.
   PubMed Web of Science ®Google Scholar
• Selvi F, Sutorý K. 2012. A synopsis of the genus Cynoglossum (Boraginaceae-Cynoglosseae) in Italy. Plant Biosyst. 146(2):461–479.
   Web of Science ®Google Scholar
• Shen B. 2015. A new golden age of natural products drug discovery. Cell. 163(6):1297–1300.
   PubMed Web of Science ®Google Scholar
• Sobolev AP, Mannina L, Capitani D, Sanzò G, Ingallina C, Botta B, Fornarini S, Crestoni ME, Chiavarino B, Carradori S, et al. 2018. A multi-methodological approach in the study of Italian PDO “Cornetto di Pontecorvo” red sweet pepper. Food Chem. 255:120–131.
   PubMed Web of Science ®Google Scholar
• Suh JH, Wang Y, Ho C-T. 2018. Natural dietary products and their effects on appetite control. J Agric Food Chem. 66(1):36–39.
   PubMed Web of Science ®Google Scholar
• Vieira MN, Lima-Filho RA, De Felice FG. 2017. Connecting Alzheimer's disease to diabetes: underlying mechanisms and potential therapeutic targets. Neuropharmacology. 136:160–171.
   PubMed Web of Science ®Google Scholar
• Weng S, Mao L, Gong Y, Sun T, Gu Q. 2017. Role of quercetin in protecting ARPE-19 cells against H2O2-induced injury via nuclear factor erythroid 2 like 2 pathway activation and endoplasmic reticulum stress inhibition. Mol Med Rep. 16(3):3461–3468.
   PubMed Web of Science ®Google Scholar
• Zengin G, Abdallah HH, Dogan A, Mollica A, Aumeeruddy-Elalfi Z, Mahomoodally MF. 2018a. Phenolic components and assessment of biological properties of Tchihatchewia isatidea Boiss. extracts: docking and functional approaches for designing novel products. Food Chem Toxicol. 111:423–431.
   PubMed Web of Science ®Google Scholar
• Zengin G, Bulut G, Mollica A, Haznedaroglu MZ, Dogan A, Aktumsek A. 2017a. Bioactivities of Achillea phrygia and Bupleurum croceum based on the composition of phenolic compounds: in vitro and in silico approaches. Food Chem Toxicol. 107:597–608.
   PubMed Web of Science ®Google Scholar
• Zengin G, Llorent-Martínez EJ, Fernández-de Córdova ML, Bahadori MB, Mocan A, Locatelli M, Aktumsek A. 2018b. Chemical composition and biological activities of extracts from three Salvia species: S. blepharochlaena, S. euphratica var. leiocalycina, and S. verticillata subsp. amasiaca. Ind Crops Prod. 111:11–21.
   Web of Science ®Google Scholar
• Zengin G, Uysal A, Aktumsek A, Mocan A, Mollica A, Locatelli M, Custodio L, Neng NR, Nogueira JMF, Aumeeruddy-Elalfi Z, et al. 2017b. Euphorbia denticulata Lam.: a promising source of phyto-pharmaceuticals for the development of novel functional formulations. Biomed Pharmacother. 87:27–36.
   PubMed Web of Science ®Google Scholar
• Zhang H, Ma ZF. 2018. Phytochemical and pharmacological properties of Capparis spinosa as a medicinal plant. Nutrients. 10(2):116.
   PubMed Web of Science ®Google Scholar