References
- Appella , E and Anderson , CW . 2000 . Signaling to p53: breaking the posttranslational modification code . Pathol Biol , 48 : 227 – 245 .
- Baek , KH , Kim , MS , Kim , YS , Shin , JM and Choi , HK . 2004 . DUB‐1A, a novel deubiquitinating enzyme subfamily member, is polyubiquitinated and cytokine‐inducible in B‐lymphocytes . J Biol Chem , 279 : 2368 – 2376 .
- Chau , V , Tobias , JW , Bachmair , A , Marriott , D , Ecker , DJ , Gonda , DK and Varshavsky , A . 1989 . A multiubiquitin chain is confined to specific lysine in a targeted short‐lived protein . Science , 243 : 1576 – 1583 .
- Ciechanover , A . 1998 . The ubiquitin‐proteasome pathway: on protein death and cell life . EMBO J , 17 : 7151 – 7160 .
- Cummins , JM and Vogelstein , B . 2004 . HAUSP is required for p53 destabilization . Cell Cycle , 3 : 689 – 692 .
- Everett , RD , Meredith , M , Orr , A , Cross , A , Kathoria , M and Parkinson , J . 1997 . A novel ubiquitin‐specific protease is dynamically associated with the PML nuclear domain and binds to a herpesvirus regulatory protein . EMBO J , 16 : 1519 – 1530 .
- Freiman , RN and Tjian , R . 2003 . Regulating the regulators: lysine modifications make their mark . Cell , 112 : 11 – 17 .
- Glickman , MH and Ciechanover , A . 2002 . The ubiquitin‐proteasome proteolytic pathway: destruction for the sake of construction . Physiol Rev , 82 : 373 – 428 .
- Haupt , Y , Maya , R , Kazaz , A and Oren , M . 1997 . Mdm2 promotes the rapid degradation of p53 . Nature , 387 : 296 – 299 .
- Hershko , A and Ciechanover , A . 1998 . The ubiquitin system . Annu Rev Biochem , 67 : 425 – 479 .
- Honda , R , Tanaka , H and Yasuda , H . 1997 . Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53 . FEBS Lett , 420 : 25 – 27 .
- Hu , M , Li , P , Li , M , Li , W , Yao , T , Wu , JW , Gu , W , Cohen , RE and Shi , Y . 2002 . Crystal structure of a UBP‐family deubiquitinating enzyme in isolation and in complex with ubiquitin aldehyde . Cell , 111 : 1041 – 1054 .
- Kim , JH , Park , KC , Chung , SS , Bang , O and Chung , CH . 2003 . Deubiquitinating enzymes as cellular regulators . J Biochem , 134 : 9 – 18 .
- Kubbutat , MH , Jones , SN and Vousden , KH . 1997 . Regulation of p53 stability by Mdm2 . Nature , 387 : 299 – 303 .
- Layfield , R , Alban , A , Mayer , RJ and Lowe , J . 2001 . The ubiquitin protein catabolic disorders . Neuropathol Appl Neurobiol , 27 : 171 – 179 .
- Li , M , Brooks , CL , Kon , N and Gu , W . 2004 . A dynamic role of HAUSP in the p53‐Mdm2 pathway . Mol Cell , 13 : 879 – 886 .
- Li , M , Chen , D , Shiloh , A , Luo , J , Nikolaev , AY , Qin , J and Gu , W . 2002 . Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization . Nature , 416 : 648 – 653 .
- Lim , SK , Shin , JM , Kim , YS and Baek , KH . 2004 . Identification and characterization of murine mHAUSP encoding a deubiquitinating enzyme that regulates the status of p53 ubiquitination . Int J Oncol , 24 : 357 – 364 .
- Menard , R , Carriere , J , Laflamme , P , Plouffe , C , Khouri , HE , Vernet , T , Tessier , DC , Thomas , DY and Storer , AC . 1991 . Contribution of the glutamine 19 side chain to transition‐state stabilization in the oxyanion hole of papain . Biochemistry , 30 : 8924 – 8928 .
- Pickart , CM . 2001 . Mechanisms underlying ubiquitination . Annu Rev Biochem , 70 : 503 – 533 .
- Quesada , V , Diaz‐Perales , A , Gutierrez‐Fernandez , A , Garabaya , C , Cal , S and Lopez‐Otin , C . 2004 . Cloning and enzymatic analysis of 22 novel human ubiquitin‐specific proteases . Biochem Biophys Res Commun , 314 : 54 – 62 .
- Salomoni , P and Pandolfi , PP . 2002 . p53 De‐ubiquitination: at the edge between life and death . Nat Cell Biol , 4 : E152 – 153 .
- Sui , G , Affarel , B , Shi , Y , Brignone , C , Wall , NR , Yin , P , Donohoe , M , Luke , MP , Calvo , D , Grossman , SR and Shi , Y . 2004 . Yin Yang 1 is a negative regulator of p53 . Cell , 117 : 859 – 872 .
- Vugmeyster , Y , Borodovsky , A , Maurice , MM , Maehr , R , Furman , MH and Ploegh , HL . 2002 . The ubiquitin‐proteasome pathway in thymocyte apoptosis: caspase‐dependent processing of the deubiquitinating enzyme USP7 (HAUSP) . Mol Immunol , 39 : 431 – 441 .
- Wilkinson , KD . 2000 . Ubiquitination and deubiquitination: targeting of proteins for degradation by the proteasome . Semin Cell Dev Biol , 11 : 141 – 148 .
- These authors contributed equally to this work.
- To whom correspondence should be addressed. Tel: 82–2–3468–3197, Fax: 82–2–3468–3264 E‐mail: [email protected]