Deregulation of the circadian clock constitutes a significant factor in tumorigenesis: a clockwork cancer. Part I: clocks and clocking machinery

References

• Johnson CH, Golden SS, Ishiura M, Kondo T. Circadian clocks in prokaryotes. Mol Microbiol. 1996;21:5–11.
   PubMed Web of Science ®Google Scholar
• Kronauer RE, Forger DB, Jewett ME. Quantifying human circadian pacemaker response to brief, extended and repeated light stimuli over the phototopic range. J Biol Rhythms. 1999;14(6):500–515.
   PubMed Web of Science ®Google Scholar
• Nagoshi E, Saini C, Bauer C, Laroche T, Naef F, Schibler U. Circadian gene expression in individual fibroblasts: cell-autonomous and self-sustained oscillators pass time to daughter cells. Cell. 2004;119(5):693–705.
   PubMed Web of Science ®Google Scholar
• Kaeffer B, Pardini L. Clock genes of mammalian cells: practical implications in tissue culture. In Vitr Cell Dev Biol Anim. 2005;41(10):311–320.
   PubMed Web of Science ®Google Scholar
• Farnell YF, Shende VR, Neuendorff N, Allen GC, Earnest DJ. Immortalized cell lines for real-time analysis of circadian pacemaker and peripheral oscillator properties. Eur J Neurosci. 2011;33(8):1533–1540.
   PubMed Web of Science ®Google Scholar
• Chepesiuk R. Missing the dark: health effects of light pollution. Environ Health Perspect. 2009;117(1):A20–A27.
   PubMed Web of Science ®Google Scholar
• Zheleva M. The dark side of light. Light pollution kills leatherback turtle hatchlings. Biodiscovery. 2012;3:4.
   Google Scholar
• Bui S, Oppedal F, Korsøen ØJ, Sonny D, Dempster T. Group behavioural responses of Atlantic salmon (Salmo salar L.) to light, infrasound and sound stimuli. PLoS One. 2013;8(5):e63696.
   Google Scholar
• Dominoni D, Quetting M, Partecke J. Artificial light at night advances avian reproductive physiology. Proc Biol Sci. 2013;280(1756):20123017.
   PubMed Web of Science ®Google Scholar
• Lee C, Etchegaray JP, Cagampang FR, Loudon AS, Reppert SM. Posttranslational mechanisms regulate the mammalian circadian clock. Cell. 2001;107(7):855–867.
   PubMed Web of Science ®Google Scholar
• Sato TK, Yamada RG, Ukai H, Baggs JE, Miraglia LJ, Kobayashi TJ, Welsh DK, Kay SA, Ueda HR, Hogenesch JB. Feedback repression is required for mammalian circadian clock function. Nat Genet. 2006;38(3):312–319.
   PubMed Web of Science ®Google Scholar
• Kondratov RV, Kondratova AA, Lee C, Gorbacheva VY, Chernov MV, Antoch MP. Post-translational regulation of circadian transcriptional CLOCK(NPAS2)/BMAL1 complex by CRYPTOCHROMES. Cell Cycle. 2006;5(8):890–895.
   PubMed Web of Science ®Google Scholar
• Oishi K, Miyazaki K, Kadota K, Kikuno R, Nagase T, Atsumi G, Ohkura N, Azama T, Mesaki M, Yukimasa S, Kobayashi H, Iitaka C, Umehara T, Horikoshi M, Kudo T, Shimizu Y, Yano M, Monden M, Machida K, Matsuda J, Horie S, Todo T, Ishida N. Genome-wide expression analysis of mouse liver reveals CLOCK-regulated circadian output genes. J Biol Chem. 2003;278(42):41519–41527.
   PubMed Web of Science ®Google Scholar
• Bozek K, Relógio A, Kielbasa SM, Heine M, Dame C, Kramer A, Herzel H. Regulation of clock-controlled genes in mammals. PLoS One. 2009;4(3):e4882.
   PubMed Web of Science ®Google Scholar
• Gekakis N, Staknis D, Nguyen HB, Davis FC, Wilsbacher LD, King DP, Takahashi JS, Weitz CJ. Role of the CLOCK protein in the mammalian circadian mechanism. Science. 1998;280(5369):1564–1569.
   PubMed Web of Science ®Google Scholar
• Griffin EA Jr, Staknis D, Weitz CJ. Light-independent role of CRY1 and CRY2 in the mammalian circadian clock. Science. 1999;286(5440):768–771.
   PubMed Web of Science ®Google Scholar
• Langmesser S, Tallone T, Bordon A, Rusconi S, Albrecht U. Interaction of circadian clock proteins PER2 and CRY with BMAL1 and CLOCK. BMC Mol Biol. 2008;9:41.
   PubMed Web of Science ®Google Scholar
• Padmanabhan K, Robles MS, Westerling T, Weitz CJ. Feedback regulation of transcriptional termination by the mammalian circadian clock PERIOD complex. Science. 2012; 337(6094):599–602.
   PubMed Web of Science ®Google Scholar
• Sangoram AM, Saez L, Antoch MP, Gekakis N, Staknis D, Whiteley A, Fruechte EM, Vitaterna MH, Shimomura K, King DP, Young MW, Weitz CJ, Takahashi JS. Mammalian circadian autoregulatory loop: a timeless ortholog and mPer1 interact and negatively regulate CLOCK-BMAL1-induced transcription. Neuron. 1998;21:1101–1113.
   PubMed Web of Science ®Google Scholar
• Honma S, Kawamoto T, Takagi Y, Fujimoto K, Sato F, Noshiro M, Kato Y, Honma K. Dec1 and Dec2 are regulators of the mammalian molecular clock. Nature. 2002;419(6909):841–844.
   PubMed Web of Science ®Google Scholar
• Marra G, Anti M, Percesepe A, Armelao F, Ficarelli R, Coco C, Rinelli A, Vecchio FM, D’Arcangelo E. Circadian variations of epithelial cell proliferation in human rectal crypts. Gastroenterology. 1994;106(4):982–987.
   PubMed Web of Science ®Google Scholar
• Janich P, Toufighi K, Solanas G, Luis NM, Minkwitz S, Serrano L, Lehner B, Benitah SA. Human epidermal stem cell function is regulated by circadian oscillations. Cell Stem Cell. 2013;13(6):745–753.
   PubMed Web of Science ®Google Scholar
• Casanova-Acebes M, Pitaval C, Weiss LA, Nombela-Arrieta C, Chèvre R, A-González N, Kunisaki Y, Zhang D, van Rooijen N, Silberstein LE, Weber C, Nagasawa T, Frenette PS, Castrillo A, Hidalgo A. Rhythmic modulation of the hematopoietic niche through neutrophil clearance. Cell. 2013;153(5):1025–1035.
   PubMed Web of Science ®Google Scholar
• Nguyen KD, Fentress SJ, Qiu Y, Yun K, Cox JS, Chawla A. Circadian gene Bmal1 regulates diurnal oscillations of Ly6C(hi) inflammatory monocytes. Science. 2013;341(6153):1483–1488.
   PubMed Web of Science ®Google Scholar
• Janich P, Pascual G, Merlos-Suárez A, Batlle E, Ripperger J, Albrecht U, Cheng HY, Obrietan K, Di Croce L, Benitah SA. The circadian molecular clock creates epidermal stem cell heterogeneity. Nature.2011;480(7376):209–214.
   PubMed Web of Science ®Google Scholar
• Bouchard-Cannon P, Mendoza-Viveros L, Yuen A, Kærn M, Cheng HY. The circadian molecular clock regulates adult hippocampal neurogenesis by controlling the timing of cell-cycle entry and exit. Cell Rep. 2013;5(4):961–973.
   Web of Science ®Google Scholar
• Bellesi M, Pfister-Genskow M, Maret S, Keles S, Tononi G, Cirelli C. Effects of sleep and wake on oligodendrocytes and their precursors. J Neurosci. 2013;33(36):14288–14300.
   PubMed Web of Science ®Google Scholar
• Smaaland R, Laerum OD, Lote K, Sletvold O, Sothern RB, Bjerknes R. DNA synthesis in human bone marrow is circadian stage dependent. Blood. 1991;77:2603–2611.
   PubMed Web of Science ®Google Scholar
• Griniatsos J, Michail OP, Theocharis S, Arvelakis A, Papaconstantinou I, Felekouras E, Pikoulis E, Karavokyros I, Bakoyiannis C, Marinos G, Bramis J, Michail PO. Circadian variation in expression of G1 phase cyclins D1 and E and cyclin-dependent kinase inhibitors p16 and p21 in human bowel mucosa. World J Gastroenterol. 2006;12(13):2109–2114.
   PubMed Web of Science ®Google Scholar
• Paulose JK, Rucker EB 3rd, Cassone VM. Toward the beginning of time: circadian rhythms in metabolism precede rhythms in clock gene expression in mouse embryonic stem cells. PLoS One. 2012;7(11):e49555.
   Google Scholar
• Inada Y, Uchida H, Umemura Y, Nakamura W, Sakai T, Koike N, Yagita K. Cell and tissue-autonomous development of the circadian clock in mouse embryos. FEBS Lett. 2014;588(3):459–465.
   PubMed Web of Science ®Google Scholar
• O’Reilly LP, Watkins SC, Smithgall TE. An unexpected role for the clock protein timeless in developmental apoptosis. PLoS One. 2011;6(2):e17157.
   Google Scholar
• Arabadjiev B, Petkova R, Momchilova A, Chakarov S, Pankov R. Of mice and men – differential mechanisms of maintaining the undifferentiated state in mESC and hESC. Biodiscovery. 2012;3:1.
   Google Scholar
• Chen Z, McKnight SL. A conserved DNA damage response pathway responsible for coupling the cell division cycle to the circadian and metabolic cycles. Cell Cycle. 2007;6(23):2906–2912.
   PubMed Web of Science ®Google Scholar
• Gamsby JJ, Loros JJ, Dunlap JC. A phylogenetically conserved DNA damage response resets the circadian clock. J Biol Rhythms. 2009;24(3):193–202.
   PubMed Web of Science ®Google Scholar
• Lee CC. The circadian clock and tumor suppression by mammalian period genes. Methods in Enzymology. 2005;393:852–861.
   PubMed Web of Science ®Google Scholar
• Barlow C, Eckhaus MA, Schäffer AA, Wynshaw-Boris A. Atm haploinsufficiency results in increased sensitivity to sublethal doses of ionizing radiation in mice. Nat Genet. 1999;21(4):359–360.
   PubMed Web of Science ®Google Scholar
• Fu L, Pelicano H, Liu J, Huang P, Lee C. The circadian gene Period2 plays an important role in tumor suppression and DNA damage response in vivo. Cell. 2002;111(1):41–50.
   PubMed Web of Science ®Google Scholar
• Gery S, Komatsu N, Baldjyan L, Yu A, Koo D, Koeffler HP. The circadian gene per1 plays an important role in cell growth and DNA damage control in human cancer cells. Mol Cell. 2006;22(3):375–382.
   PubMed Web of Science ®Google Scholar
• Chen-Goodspeed M, Lee CC. Tumor suppression and circadian function. J Biol Rhythms. 2007;22(4):291–298.
   PubMed Web of Science ®Google Scholar
• Bao S, Tibbetts RS, Brumbaugh KM, Fang Y, Richardson DA, Ali A, Chen SM, Abraham RT, Wan X-F. ATR/ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress responses. Nature. 2001:411(6840):969–974.
   PubMed Web of Science ®Google Scholar
• Khalil HS, Tummala H, Chakarov S, Zhelev N, Lane DP. Targeting ATM pathway for therapeutic intervention in cancer. Biodiscovery. 2012;1:3.
   Google Scholar
• Khalil HS, Tummala H, Zhelev N. ATM in focus: A damage sensor and cancer target. Biodiscovery. 2012;5:1.
   Google Scholar
• Lee CH, Chung JH. The hCds1 (Chk2)-FHA domain is essential for a chain of phosphorylation events on hCds1 that is induced by ionising radiation. J Biol Chem. 2001;276(32):30537–30541.
   PubMed Web of Science ®Google Scholar
• Chehab NH, Malikzay A, Appel M, Halazonetis TD. Chk2/hCds1 functions as a DNA damage checkpoint in G-1 by stabilising p53. Genes Dev. 2000;14:278–288.
   PubMed Web of Science ®Google Scholar
• Tang J, Erikson RL, Liu X. Checkpoint kinase 1 (Chk1) is required for mitotic progression through negative regulation of polo-like kinase 1 (Plk1). Proc Natl Acad Sci USA. 2006;103:11964–11969.
   PubMed Web of Science ®Google Scholar
• Yang X, Wood PA, Hrushesky WJ. Mammalian TIMELESS is required for ATM-dependent CHK2 activation and G2/M checkpoint control. J Biol Chem. 2010;285(5):3030–3034.
   PubMed Web of Science ®Google Scholar
• Rahman-Roblick R, Roblick UJ, Hellman U, Conrotto P, Liu T, Becker S, Hirschberg D, Jörnvall H, Auer G, Wiman KG. p53 targets identified by protein expression profiling. Proc Natl Acad Sci USA. 2007;104(13):5401–5406.
   PubMed Web of Science ®Google Scholar
• Huart AS, Hupp TR. Evolution of conformational disorder & diversity of the P53 interactome. BioDiscovery. 2013;8:5.
   Google Scholar
• Banin S, Moyal L, Shieh S, Taya Y, Anderson CW, Chessa L, Smorodinsky NI, Prives C, Reiss Y, Shiloh Y, Ziv Y. Enhanced phosphorylation of p53 by ATM in response to DNA damage. Science. 1998;281(5383):1674–1677.
   PubMed Web of Science ®Google Scholar
• Chakarov S, Petkova R, Russev GCh. p53 – guardian angel and archangel. Biotechnol Biotechnol Equipment. 2012;26(1):2695–2702.
   Web of Science ®Google Scholar
• Khosravi R, Maya R, Gottlieb T, Oren M, Shiloh Y, Shkedy D. Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage. Proc Natl Acad Sci USA. 1999;96(26):14973–14977.
   PubMed Web of Science ®Google Scholar
• Loughery J, Meek D. Switching on p53: an essential role for protein phosphorylation? BioDiscovery. 2013;8:1.
   Google Scholar
• Miki T, Matsumoto T, Zhao Z, Lee CC. p53 regulates Period2 expression and the circadian clock. Nat Commun. 2013;4:2444.
   PubMed Web of Science ®Google Scholar
• Ozturk N, Lee JH, Gaddameedhi S, Sancar A. Loss of cryptochrome reduces cancer risk in p53 mutant mice. Proc Natl Acad Sci USA. 2009;106(8):2841–2846.
   PubMed Web of Science ®Google Scholar
• Mullenders J, Fabius AW, Madiredjo M, Bernards R, Beijersbergen RL. A large scale shRNA barcode screen identifies the circadian clock component ARNTL as putative regulator of the p53 tumor suppressor pathway. PLoS One. 2009;4(3):e4798.
   PubMed Web of Science ®Google Scholar
• Ishihara H, Tanaka I, Yakumaru H, Chikamori M, Ishihara F, Tanaka M, Ishiwata A, Kurematsu A, Satoh A, Ueda J, Akashi M. Circadian transitions in radiation dose-dependent augmentation of mRNA levels for DNA damage-induced genes elicited by accurate real-time RT-PCR quantification. J Radiat Res. 2010;51(3):265–275.
   Web of Science ®Google Scholar
• Filipski E, Innominato PF, Wu M, Li X M, Iacobelli S, Xian L J, Levi F. Effects of light and food schedules on liver and tumor molecular clocks in mice. J Natl Cancer Inst. 2005;97:507–517.
   PubMed Web of Science ®Google Scholar
• Honma S, Ikeda M, Abe H, Tanahashi Y, Namihira M, Honma K, Nomura M. Circadian oscillation of BMAL1, a partner of a mammalian clock gene Clock, in rat suprachiasmatic nucleus. Biochem Biophys Res Commun. 1998;250:83–87.
   PubMed Web of Science ®Google Scholar
• Bhawal UK, Sato F, Arakawa Y, Fujimoto K, Kawamoto T, Tanimoto K, Ito Y, Sasahira T, Sakurai T, Kobayashi M, Kashima I, Kijima H, Kuniyasu H, Abiko Y, Kato Y, Sato S. Basic helix-loop-helix transcription factor DEC1 negatively regulates cyclin D1. J Pathol. 2011;224(3):420–429.
   PubMed Web of Science ®Google Scholar
• Matsuo T, Yamaguchi S, Mitsui S, Emi A, Shimoda F, Okamura H. Control mechanism of the circadian clock for timing of cell division in vivo. Science. 2003;302(5643):255–259.
   PubMed Web of Science ®Google Scholar
• Kang TH, Reardon JT, Kemp M, Sancar A. Circadian oscillation of nucleotide excision repair in mammalian brain. Proc Natl Acad Sci USA. 2009;106(8):2864–2867.
   PubMed Web of Science ®Google Scholar
• Sancar A, Lindsey-Boltz LA, Kang TH, Reardon JT, Lee JH, Ozturk N. Circadian clock control of the cellular response to DNA damage. FEBS Lett. 2010;584(12):2618–2625.
   PubMed Web of Science ®Google Scholar
• Gaddameedhi S, Reardon JT, Ye R, Ozturk N, Sancar A. Effect of circadian clock mutations on DNA damage response in mammalian cells. Cell Cycle. 2012;11(18):3481–3491.
   PubMed Web of Science ®Google Scholar
• Kang TH, Lindsey-Boltz LA, Reardon JT, Sancar A. Circadian control of XPA and excision repair of cisplatin-DNA damage by cryptochrome and HERC2 ubiquitin ligase. Proc Natl Acad Sci USA. 2010;107(11):4890–4895.
   PubMed Web of Science ®Google Scholar
• Marchenay C, Cellarier E, Lévi F, Rolhion C, Kwiatkowski F, Claustrat B, Madelmont JC, Chollet P. Circadian variation in O6-alkylguanine-DNA alkyltransferase activity in circulating blood mononuclear cells of healthy human subjects. Int J Cancer. 2001;91(1):60–66.
   PubMed Web of Science ®Google Scholar
• Kim J, Matsunaga N, Koyanagi S, Ohdo S. Clock gene mutation modulates the cellular sensitivity to genotoxic stress through altering the expression of N-methylpurine DNA glycosylase gene. Biochem Pharmacol. 2009;78(8):1075–1082.
   PubMed Web of Science ®Google Scholar
• Nouspikel T, Hanawalt PC. Terminally differentiated human neurons repair transcribed genes but display attenuated global DNA repair and modulation of repair gene expression. Mol Cell Biol. 2000;20(5):1562–1570.
   PubMed Web of Science ®Google Scholar
• Chakarov S, Russev G. DNA repair and cell differentiation - does getting older means getting wiser as well? Biotechnol Biotechnol Equipment. 2010;24(2):1804–1806.
   Web of Science ®Google Scholar
• Grimaldi B, Nakahata Y, Sahar S, Kaluzova M, Gauthier D, Pham K, Patel N, Hirayama J, Sassone-Corsi P. Chromatin remodeling and circadian control: master regulator CLOCK is an enzyme. Cold Spring Harbor Symp Quantitative Biol. 2007;72:105–112.
   PubMedGoogle Scholar
• Grimaldi B, Nakahata Y, Kaluzova M, Masubuchi S, Sassone-Corsi P. Chromatin remodeling, metabolism and circadian clocks: the interplay of CLOCK and SIRT1. Int J Biochem Cell Biol. 2009;41(1):81–86.
   PubMed Web of Science ®Google Scholar
• Wang Z, Zang C, Rosenfeld JA, Schones DE, Barski A, Cuddapah S, Cui K, Roh TY, Peng W, Zhang MQ, Zhao K. Combinatorial patterns of histone acetylations and methylations in the human genome. Nat Genet. 2008;40(7):897–903.
   PubMed Web of Science ®Google Scholar
• Hirayama J, Sahar S, Grimaldi B, Tamaru T, Takamatsu K, Nakahata Y, Sassone-Corsi P. CLOCK-mediated acetylation of BMAL1 controls circadian function. Nature. 2007; 450(7172):1086–1090.
   PubMed Web of Science ®Google Scholar
• Chakarov S, Vassilev P, Tencheva Z, Angelova A. Isolation and properties of human recombinant high mobility group I/Y chromosomal protein. Biotechnol Biotechnol Equipment. 1997;11(3–4):46–50.
   Web of Science ®Google Scholar
• Reeves R, Beckerbauer L. HMGI/Y proteins: flexible regulators of transcription and chromatin structure. Biochim Biophys Acta. 2001;1519(1–2):13–29.
   PubMed Web of Science ®Google Scholar
• Liu Y, Prasad R, Wilson SH. HMGB1: roles in base excision repair and related function. Biochim Biophys Acta. 2010;1799(1–2):119–130.
   PubMed Web of Science ®Google Scholar
• Schärer OD. Multistep damage recognition, pathway coordination and connections to transcription, damage signalling, chromatin structure, cancer and ageing: current perspectives on the nucleotide excision repair pathway. DNA Repair (Amst). 2011;10(7):667.
   PubMed Web of Science ®Google Scholar
• Chakarov S, Chakalova L, Tencheva Z, Ganev V, Angelova A. Morphine treatment affects the regulation of high mobility group I-type chromosomal phosphoproteins in C6 glioma cells. Life Sci. 2000;66(18):1725–1731.
   PubMed Web of Science ®Google Scholar
• Ugrinova I, Zlateva S, Pashev IG, Pasheva EA. Native HMGB1 protein inhibits repair of cisplatin-damaged nucleosomes in vitro. Int J Biochem Cell Biol. 2009;41(7):1556–1562.
   PubMed Web of Science ®Google Scholar
• Chakarov S, Chakalova L, Tencheva Z, Angelova A. HMG I/Y chromosome proteins in developing rat brain cells. C R Acad Bulg Sci. 1995;48(11–12):139–141.
   Google Scholar
• Zhou X, Benson KF, Ashar HR, Chada K. Mutation responsible for the mouse pygmy phenotype in the developmentally regulated factor HMGI-C. Nature. 1995;376(6543):771–774.
   PubMed Web of Science ®Google Scholar
• Angelova A, Chakarov S, Tencheva Z. Effect of the HMG I/Y chromosomal proteins on the RNA polymerase activity in isolated brain nuclei. C R Acad Bulg Sci. 1998;51(5/6):91–92.
   Google Scholar
• Hoppe G, Rayborn M.E, Sears JE. Diurnal rhythm of the chromatin protein Hmgb1 in rat photoreceptors is under circadian regulation. J Comp Neurol. 2007;501(2):219–230.
   PubMed Web of Science ®Google Scholar
• Adair JE, Kwon Y, Dement GA, Smerdon MJ, Reeves R. Inhibition of nucleotide excision repair by high mobility group protein HMGA1. J Biol Chem. 2005;80:32184–32192.
   Web of Science ®Google Scholar
• Adair JE, Maloney SC, Dement GA, Wertzler KJ, Smerdon MJ, Reeves R. High-mobility group A1 proteins inhibit expression of nucleotide excision repair factor xeroderma pigmentosum group A. Cancer Res. 2007; 67:6044–6052.
   PubMed Web of Science ®Google Scholar
• Foti D, Chiefari E, Fedele M, Iuliano R, Brunetti L, Paonessa F, Manfioletti G, Barbetti F, Brunetti A, Croce CM, Fusco A, Brunetti A. Lack of the architectural factor HMGA1 causes insulin resistance and diabetes in humans and mice. Nat Med. 2005;11(7):765–773.
   PubMed Web of Science ®Google Scholar
• Chiefari E, Tanyolaç S, Paonessa F, Pullinger CR, Capula C, Iiritano S, Mazza T, Forlin M, Fusco A, Durlach V, Durlach A, Malloy MJ, Kane JP, Heiner SW, Filocamo M, Foti DP, Goldfine ID, Brunetti A. Functional variants of the HMGA1 gene and type 2 diabetes mellitus. JAMA. 2011;305(9):903–912.
   PubMed Web of Science ®Google Scholar
• Chiappetta G, Manfioletti G, Pentimalli F, Abe N, Di Bonito M, Vento MT, Giuliano A, Fedele M, Viglietto G, Santoro M, Watanabe T, Giancotti V, Fusco A. High mobility group HMGI(Y) protein expression in human colorectal hyperplastic and neoplastic diseases Int J Cancer 2001;91(2):147–151.
   PubMed Web of Science ®Google Scholar
• Sgarra R, Rustighi A, Tessari MA, Di Bernardo J, Altamura S, Fusco A, Manfioletti G, Giancotti V. Nuclear phosphoproteins HMGA and their relationship with chromatin structure and cancer. FEBS Lett. 2004;574:1–8.
   PubMed Web of Science ®Google Scholar
• Kostova N, Zlateva S, Ugrinova I, Pasheva E. The expression of HMGB1 protein and its receptor RAGE in human malignant tumors. Mol Cell Biochem. 2010;337(1–2):251–258.
   PubMed Web of Science ®Google Scholar
• Erol A. Metabolic syndrome is a real disease and premalignant state induced by oncogenic stresses to block malignant transformation. Med Hypotheses. 2010;74(6):1038–1043.
   PubMed Web of Science ®Google Scholar
• Petkova R, Tummala H, Zhelev N. Nothing in excess – lessons learned from the expression of high-mobility group proteins type A in non-cancer and cancer cells. Biotechnol Biotechnol Equipment. 2011;25(4):2572–2575.
   Web of Science ®Google Scholar