Main properties of nanocrystalline hydroxyapatite as a bone graft material in treatment of periodontal defects. A review of literature

References

• Fleckenstein KB, Cuenin MF, Peacock ME, et al. Effect of a hydroxyapatite tricalcium phosphate alloplast on osseous repair in the rat calvarium. J Periodontol. 2006;77(1):39–45.
   PubMed Web of Science ®Google Scholar
• Lang NP. Focus on intrabony defects – conservative therapy. Periodontology 2000;22:51–58.
   Web of Science ®Google Scholar
• Scabbia A, Trombelli L. A comparative study on the use of a HA/collagen/chondroitin sulphate biomaterial (Biostite) and a bovine-derived HA xenograft (Bio-Oss) in the treatment of deep intra-osseous defects. J Clin Periodontol. 2004;31(5):348–355.
   PubMed Web of Science ®Google Scholar
• Aichelmann-Reidy ME, Yukna RA. Bone replacement grafts. The bone substitutes. Dent Clin North Am. 1998;42(3):491–503.
   PubMedGoogle Scholar
• Saffar JL, Colombier ML, Detienville R. Bone formation in tricalcium phosphate-filled periodontal intrabony lesions. Histological observations in humans. J Periodontol. 1990;61(4):209–216.
   PubMed Web of Science ®Google Scholar
• Kenney EB, Lekovic V, Han T, et al. The use of a porous hydroxylapatite implant in periodontal defects. I. Clinical results after six months. J Periodontol. 1985;56(2):82–88.
   PubMed Web of Science ®Google Scholar
• Ganeles J, Listgarten MA, Evian CI. Ultrastructure of durapatite-periodontal tissue interface in human intrabony defects. J Periodontol. 1986;57(3):133–140.
   PubMed Web of Science ®Google Scholar
• Newman MG, Takei H, Klokkevold PR, et al. Carranza's clinical periodontology. 12th ed. St. Louis (MO): Saunders Elsevier; 2014.
   Google Scholar
• Mann S. Principles and concepts in bioinorganic materials chemistry. New York (NY): Oxford University Press; 2001 p. 324.
   Google Scholar
• Wang L, Nancollas GH. Calcium orthophosphates: crystallization and dissolution. Chem Rev. 2008;108(11):4628–4669.
   PubMed Web of Science ®Google Scholar
• Meffert RM, Thomas JR, Hamilton KM, et al. Hydroxylapatite as an alloplastic graft in the treatment of human periodontal osseous defects. J Periodontol. 1985;56(2):63–73.
   PubMed Web of Science ®Google Scholar
• Eichert C, Drouet C, Sfihi H, et al. Nanocrystalline apatite-based biomaterials: synthesis, processing and characterization. In: Kendall JB, editor. Biomaterials research advances. Hauppauge (NY): Nova Science Publishers, Inc; 2007. p. 93–143.
   Google Scholar
• Kawai K, Larson BJ, Ishise H, et al. Calcium-based nanoparticles accelerate skin wound healing. PLoS One. 2011;6(11):e27106.
   PubMed Web of Science ®Google Scholar
• Kanaya S, Nemoto E, Sakisaka Y, et al. Calcium-mediated increased expression of fibroblast growth factor-2 acts through NF-kappaB and PGE2/EP4 receptor signaling pathways in cementoblasts. Bone. 2013;56(2):398–405.
   PubMed Web of Science ®Google Scholar
• Yang C, Lee J-S, Jung UW, et al. Periodontal regeneration with nano-hyroxyapatite-coated silk scaffolds in dogs. J Periodontal Implant Sci. 2013;43(6):315–322.
   PubMed Web of Science ®Google Scholar
• Saleh RG, El Tokhey AO, El-Guindy HM. Evaluation of hydroxyapatite nanoparticles with and without silver nanoparticles in the treatment of induced periodontitis in dogs. J Am Sci. 2014;10:21–33.
   Google Scholar
• Hossein Shahoon RH, Yadegari Z, Hosseiny VAM, et al. The comparison of silver and hydroxyapatite nanoparticles biocompatibility on L929 fibroblast cells. J Nanomed Nanotechol. 2013;4(4):1000173.
   Google Scholar
• Sun W, Chu C, Wang J, et al. Comparison of periodontal ligament cells responses to dense and nanophase hydroxyapatite. J Mater Sci Mater Med. 2007;18(5):677–683.
   PubMed Web of Science ®Google Scholar
• Schnettler R, Alt SJ, Pavlidis V, et al. PD Calcium phosphate-based bone substitutes. Eur J Trauma. 2004;1(30):219–229.
   Google Scholar
• Thian ES, Huang J, Ahmad Z et al. Influence of nanohydroxyapatite patterns deposited by electrohydrodynamic spraying on osteblast response. J Biomed Mater Res. 2008;865:188–194.
   Web of Science ®Google Scholar
• Pilloni A, Pompa G, Saccucci M, et al. Analysis of human alveolar osteoblast behavior on a nano-hydroxyapatite substrate: an in vitro study. BMC Oral Health. 2014;14:22.
   PubMed Web of Science ®Google Scholar
• Webster TJ, Ergun C, Doremus RH, et al. Enhanced functions of osteoblasts on nanophase ceramics. Biomaterials. 2000;21(17):1803–1810.
   PubMed Web of Science ®Google Scholar
• Liu X, Zhao MZ, Lu JX, et al. Cell responses to two kinds of nanohydroxyapatite with different sizes and crystallinities. Int J Nanomed. 2012;7:1239–1250.
   PubMed Web of Science ®Google Scholar
• Motskin M, Wright DM, Muller K, et al. Hydroxyapatite nano and microparticles: correlation of particle properties with cytotoxicity and biostability. Biomaterials. 2009;30(19):3307–3317.
   PubMed Web of Science ®Google Scholar
• Hsieh MF, Li JK-J, Lin C-AJ, et al. Tracking of cellular uptake of hydrophilic CdSe/ZnS quantum dots/hydroxyapatite composites nanoparticles in MC3T3-E1 osteoblast cells. J Nanosci Nanotechnol. 2009;9(4):2758–2762.
   PubMed Web of Science ®Google Scholar
• Detsch R, Hagmeyer D, Neumann M, et al. The resorption of nanocrystalline calcium phosphates by osteoclast-like cells. Acta Biomater. 2010;6:3223–3233.
   PubMed Web of Science ®Google Scholar
• Matesanz MC, Linares J, Lilue I, et al. Nanocrystalline silicon substituted hydroxyapatite effects on osteoclast differentiation and resorptive activity. J Mater Chem. 2014;2:2910–2919.
   Web of Science ®Google Scholar
• Jahangirnezhad M, Kazeminezhad I, Saki Gh, et al. The effects of nanohydroxyapatite on bone regeneration in rat calvarial defects. Am J Res Commun. 2013;1(4):302–316.
   Google Scholar
• Cecilia Vullo MM, Rossi G, Tambella AM et al. Use of nanohydroxyapatite in regenerative therapy in dogs affected by periodontopathy. Ann Clin Lab Res. 2015;3(2):18.
   Google Scholar
• Götz W, Gerber T, Michel B, et al. Immunohistochemical characterization of nanocrystalline hydroxyapatite silica gel (NanoBone(r)) osteogenesis: a study on biopsies from human jaws. Clin Oral Implants Res. 2008;19(10):1016–1026.
   PubMed Web of Science ®Google Scholar
• Huber FX, McArthur N, Hillmeier J, et al. Void filling of tibia compression fracture zones using a novel resorbable nanocrystalline hydroxyapatite paste in combination with a hydroxyapatite ceramic core: first clinical results. Arch Orthop Trauma Surg. 2006;126(8):533–540.
   PubMed Web of Science ®Google Scholar
• Zuev VP, Dmitrieva LA, Pankratov AS, et al. [The comparative characteristics of stimulators of reparative osteogenesis in the treatment of periodontal diseases]. Stomatologiia (Mosk). 1996;75(5):31–34.
   PubMedGoogle Scholar
• Talal A, McKay IJ, Tanner KE, et al. Effects of hydroxyapatite and PDGF concentrations on osteoblast growth in a nanohydroxyapatite-polylactic acid composite for guided tissue regeneration. J Mater Sci Mater Med. 2013;24(9):2211–2221.
   PubMed Web of Science ®Google Scholar
• Busenlechner D, Huber CD, Vasak C, et al. Sinus augmentation analysis revised: the gradient of graft consolidation. Clin Oral Implants Res. 2009;20(10):1078–1083.
   PubMed Web of Science ®Google Scholar
• Bertoldi C, Zaffe D. In vivo comparison of two bone substitutes in the distal femur of the rabbit. Int J Oral Maxillofac Implants. 2012;27(1):119–127.
   PubMed Web of Science ®Google Scholar
• Scheel J, Weimans S, Thiemann A, et al. Exposure of the murine RAW 264.7 macrophage cell line to hydroxyapatite dispersions of various composition and morphology: assessment of cytotoxicity, activation and stress response. Toxicol In Vitro. 2009;23(3):531–538.
   PubMed Web of Science ®Google Scholar
• Du B, Liu W, Deng Y, et al. Angiogenesis and bone regeneration of porous nano-hydroxyapatite/coralline blocks coated with rhVEGF165 in critical-size alveolar bone defects in vivo. Int J Nanomed. 2015;10:2555–2565.
   PubMed Web of Science ®Google Scholar
• Lock J, Liu H. Nanomaterials enhance osteogenic differentiation of human mesenchymal stem cells similar to a short peptide of BMP-7. Int J Nanomed. 2011;6:2769–2777.
   PubMed Web of Science ®Google Scholar
• Zhou G, Li Y, Xiao W, et al. Synthesis, characterization, and antibacterial activities of a novel nanohydroxyapatite/zinc oxide complex. J Biomed Mater Res A. 2008;85A(4):929–937.
   Web of Science ®Google Scholar
• Jain A, Pahuja CRB. Comparative evaluation of the efficacy of calcium sulfate bone grafts in crystalline and nano-crystalline forms in fresh extraction socket sites: A radiographic and histological pilot study. Int JOral Implantol Clin Res. 2012;3(1):58–61.
   Google Scholar
• Pezzatini S, Morbidelli L, Solito R, et al. Nanostructured HA crystals up-regulate FGF-2 expression and activity in microvascular endothelium promoting angiogenesis. Bone. 2007;41(4):523–534.
   PubMed Web of Science ®Google Scholar
• Thorwarth M, Schultze-Mosgau S, Kessler P, et al. Bone regeneration in osseous defects using a resorbable nanoparticular hydroxyapatite. J Oral Maxillofac Surg. 2005;63(11):1626–1633.
   PubMed Web of Science ®Google Scholar
• Canullo L, Wiel Marin G, Tallarico M, et al. Histological and histomorphometrical evaluation of postextractive sites grafted with Mg-enriched nano-hydroxyapatite: A randomized controlled trial comparing 4 versus 12 months of healing. Clin Implant Dent Relat Res. 2015;18:973–983.
   PubMed Web of Science ®Google Scholar
• Chitsazi MT, Shirmohammadi A, Faramarzie M, et al. A clinical comparison of nano-crystalline hydroxyapatite (Ostim) and autogenous bone graft in the treatment of periodontal intrabony defects. Med Oral Patol Oral Cir Bucal. 2011;16(3):e448–e453.
   PubMed Web of Science ®Google Scholar
• Elyan Al Machot TH, Lorenz K, Khalili I, et al. Clinical outcomes after treatment of periodontal intrabony defects with nanocrystalline hydroxyapatite (Ostim) or enamel matrix derivatives (Emdogain): A randomized controlled clinical trial. BioMed Res Int. 2014; Article ID 786353.
   PubMed Web of Science ®Google Scholar
• Prathap S, Hegde S, Kashyap R, et al. Clinical evaluation of porous hydroxyapatite bone graft (Periobone G) with and without collagen membrane (Periocol) in the treatment of bilateral grade II furcation defects in mandibular first permanent molars. J Indian Soc Periodontol. 2013;17(2):228–234.
   PubMedGoogle Scholar
• Singh VP, Nayak DG, Uppoor AS, et al. Clinical and radiographic evaluation of nano-crystalline hydroxyapatite bone graft (Sybograf) in combination with bioresorbable collagen membrane (Periocol) in periodontal intrabony defects. Dent Res J (Isfahan). 2012;9(1):60–67.
   PubMedGoogle Scholar
• Seifi M, Arayesh A, Shamloo N, et al. Effect of nanocrystalline hydroxyapatite socket preservation on orthodontically induced inflammatory root resorption. Cell J. 2015;16(4):514–527.
   PubMed Web of Science ®Google Scholar
• Kamboj M, Harinder RA, Gupta, Comparative evaluation of the efficacy of synthetic nanocrystalline hydroxyapatite bone graft (Ostim®) and synthetic microcrystalline hydroxyapatite bone graft (Osteogen®) in the treatment of human periodontal intrabony defects: A clinical and denta scan study. J Indian Soc Periodontol. 2016.
   PubMedGoogle Scholar
• Bansal M, Kaushik M, Khattak BP et al. Comparison of nanocrystalline hydroxyapatite and synthetic resorbable hydroxyapatite graft in the treatment of intrabony defects: A clinical and radiographic study. J Indian Soc Periodontol. 2014;18(2):213–219.
   PubMedGoogle Scholar
• Kasaj A, Röhrig B, Zafiropoulos G-G, et al. Clinical evaluation of nanocrystalline hydroxyapatite paste in the treatment of human periodontal bony defects – A randomized controlled clinical trial: 6-month results. J Periodontol. 2008;79(3):394–400.
   PubMed Web of Science ®Google Scholar
• Elgendy EA, Shady TEA, Clinical and radiographic evaluation of nanocrystalline hydroxyapatite with or without platelet-rich fibrin membrane in the treatment of periodontal intrabony defects. J Indian Soc Periodontol. 2015;19(1):61–65.
   PubMedGoogle Scholar
• Rahman H, Chandra A, Aziz A et al. Platelet rich fibrin and nanocrystalline hydroxyapatite with collagen combination in treatment of periapical lesion: A novel clinical approach. British J Med Med Res. 2015;5(2):275–282.
   Google Scholar
• Figliuzzi MM, Giudice A, Pileggi S, et al. Biomimetic hydroxyapatite used in the treatment of periodontal intrabony pockets: clinical and radiological analysis. Ann Stomatol (Roma). 2016;7(1–2):16–23.
   PubMed Web of Science ®Google Scholar
• Cecilia Vullo MM, Rossi G, Tambella AM et al. Use of nanohydroxyapatite in regenerative therapy in dogs affected by periodontopathy: Preliminary results. Ann Clin Lab Res. 2015;3(2):18.
   Google Scholar