Nanotechnology towards prevention of anaemia and osteoporosis: from concept to market

References

• De Jong WH, Borm PJA. Drug delivery and nanoparticles: applications and hazards. Int J Nanomed. 2008;3(2):133–149.
   PubMed Web of Science ®Google Scholar
• Chaudhry Q, Scotter M, Blackburn J, et al. Applications and implications of nanotechnologies for the food sector. Food Addit Contam. 2008;25(3):241–258.
   Web of Science ®Google Scholar
• Erfanian A, Mirhosseini H, Manap MYA, et al. Influence of nano-size reduction on absorption and bioavailability of calcium from fortified milk powder in rats. Food Res Int. 2014;66:1–11.
   Web of Science ®Google Scholar
• Erfanian A, Mirhosseini H, Rasti B, et al. Absorption and bioavailability of nano-size reduced calcium citrate fortified milk powder in ovariectomized and ovariectomized-osteoporosis rats. J Agric Food Chem. 2015;63(24):5795–5804.
   PubMed Web of Science ®Google Scholar
• Min KH, Park K, Kim Y-S, et al. Hydrophobically modified glycol chitosan nanoparticles-encapsulated camptothecin enhance the drug stability and tumor targeting in cancer therapy. J Control Release. 2008;127(3):208–218.
   PubMed Web of Science ®Google Scholar
• Jia L. Nanoparticle formulation increases oral bioavailability of poorly soluble drugs: approaches experimental evidences and theory. Curr Nanosci. 2005;1(3):237–243.
   PubMed Web of Science ®Google Scholar
• Mahler GJ, Esch MB, Tako E, et al. Oral exposure to polystyrene nanoparticles affects iron absorption. Nat Nanotechnol. 2012;7(4):264–271.
   PubMed Web of Science ®Google Scholar
• Database WHOG. [Internet]. Worldwide prevalence of anaemia. 2005. cited [2016 Nov 10]. Available from: http://www.who.int/vmnis/publications/anaemia_prevalence/en/
   Google Scholar
• Hurrell R, Egli I. Iron bioavailability and dietary reference values. Am J Clin Nutr. 2010;91(5):1461S–1467S.
   PubMed Web of Science ®Google Scholar
• Vikas K, Sinha AK, Makkar HPS, et al. Dietary roles of phytate and phytase in human nutrition: a review. Food Chem. 2010;120(4):945–959.
   Web of Science ®Google Scholar
• Saini RK, Nile SH, Keum Y. Food science and technology for management of iron deficiency in humans: a review. Trends Food Sci Technol. 2016;53:13–22.
   Web of Science ®Google Scholar
• Saha L, Pandhi P, Gopalan S, et al. Comparison of efficacy, tolerability, and cost of iron polymaltose complex with ferrous sulphate in the treatment of iron deficiency anemia in pregnant women. MedGenMed. 2007 [cited 2017 Mar 29];9(1):1. Available from:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1924983/
   PubMedGoogle Scholar
• Srinivasu BY, Mitra G, Muralidharan M, et al. Beneficiary effect of nanosizing ferric pyrophosphate as food fortificant in iron deficiency anemia: evaluation of bioavailability, toxicity and plasma biomarker. RSC Adv. 2015;5(76):61678–61687.
   Web of Science ®Google Scholar
• Wu H, Zhu S, Zeng M, et al. Enhancement of non-heme iron absorption by anchovy (Engraulis japonicus) muscle protein hydrolysate involves a nanoparticle-mediated mechanism. J Agric Food Chem. 2014;62(34):8632–8639.
   PubMed Web of Science ®Google Scholar
• Pereira DIA, Bruggraber SFA, Faria N, et al. Nanoparticulate iron(III) oxo-hydroxide delivers safe iron that is well absorbed and utilised in humans. Nanomedicine Nanotechnology, Biol Med. 2014;10(8):1877–1886.
   PubMed Web of Science ®Google Scholar
• Zariwala MG, Elsaid N, Jackson TL, et al. A novel approach to oral iron delivery using ferrous sulphate loaded solid lipid nanoparticles. Int J Pharm. 2013;456(2):400–407.
   PubMed Web of Science ®Google Scholar
• Eldridge JH, Hammond CJ, Meulbroek JA, et al. Controlled vaccine release in the gut-associated lymphoid tissues. I. Orally administered biodegradable microspheres target the Peyer's patches. J Control Release. 1990;11(1–3):205–214.
   Web of Science ®Google Scholar
• Severino P, Andreani T, Macedo AS, et al. Current state-of-art and new trends on lipid nanoparticles (SLN and NLC) for oral drug delivery. J Drug Deliv. 2012; [cited 2017 Mar 29];2012:750891. DOI: 10.1155/2012/750891
   PubMedGoogle Scholar
• Aungst BJ. Intestinal permeation enhancers. J Pharm Sci. 2000;89(4):429–442.
   PubMed Web of Science ®Google Scholar
• Hosny KMKM, Banjar ZM, Hariri AH, et al. Solid lipid nanoparticles loaded with iron to overcome barriers for treatment of iron deficiency anemia. Drug Des Dev Ther. 2015;9(9):313–320.
   PubMed Web of Science ®Google Scholar
• Salah EDTA, Bakr MM, Kamel HM, inventors; Innovative Research and Development Co. (Inrad), assignee, et al.. Magnetite nanoparticles as a single dose treatment for iron deficiency anemia. Google Patents. 2010; cited [2016 Nov 15]. Available from:http://www.google.co.in/patents/WO2010034319A1?cl=en
   Google Scholar
• Mahmoud MBM, Helmy SHA.inventors; European Egyptian Pharmaceutical Industries, assignee. Novel formula of iron based nanocomposites for rapid and efficient treatment of iron deficiency anemia. Google Patents. 2014; cited [2016 Nov 15]. Available from:http://www.google.co.in/patents/WO2014135170A1?cl=en
   Google Scholar
• Orphan Nutrition. Micronutrient : calcium [Internet]. 2016. cited [2016 Nov 15]. Available from: http://www.orphannutrition.org/orphan-nutrition-library/micronutrient-malnutrition-calcium/
   Google Scholar
• Christakos S, Dhawan P, Porta A, et al. Vitamin D and intestinal calcium absorption. Mol Cell Endocrinol. 2011;347(1–2):25–29.
   PubMed Web of Science ®Google Scholar
• FAO,WHO. Vitamin and mineral requirements in human nutrition Second edition. World Heal Organ [Internet]. 1998;1–20. cited [2016 Nov 16]. Available from:www.who.org
   Google Scholar
• Ho SC, Chan SG, Yip YB, et al. Change in bone mineral density and its determinants in pre- and perimenopausal Chinese women: the Hong Kong perimenopausal women osteoporosis study. Osteoporos Int. 2008;19(12):1785–1796.
   PubMed Web of Science ®Google Scholar
• Johnell O, Kanis JA. An estimate of the worldwide prevalence and disability associated with osteoporotic fractures. Osteoporos Int. 2006;17:1726–1733.
   PubMed Web of Science ®Google Scholar
• Lindsay R. Estrogen and osteoporosis. Phys Sportsmed. 1987;15(11):105–108.
   PubMed Web of Science ®Google Scholar
• Reid IR, Ames RW, Evans MC, et al. Effect of calcium supplementation on bone loss in post menopausal women. N Engl J Med. 1993;328(7):460–464.
   PubMed Web of Science ®Google Scholar
• Pentti K, Tuppurainen MT, Honkanen R, et al. Use of calcium supplements and the risk of coronary heart disease in 52–62-year-old women: the Kuopio Osteoporosis Risk Factor and Prevention Study. Maturitas. 2009;63(1):73–78.
   PubMed Web of Science ®Google Scholar
• Shin CS, Kim KM. The risks and benefits of calcium supplementation. Endocrinol Metab. 2015;30(1):27–34.
   Google Scholar
• Khajuria DK, Disha C, Vasireddi R, et al. Risedronate/zinc-hydroxyapatite based nanomedicine for osteoporosis. Mater Sci Eng C. 2016;63:78–87.
   PubMed Web of Science ®Google Scholar
• Iafisco M, Ruffini A, Adamiano A, et al. Biomimetic magnesium-carbonate-apatite nanocrystals endowed with strontium ions as anti-osteoporotic trigger. Mater Sci Eng C. 2014;35(1):212–219.
   PubMed Web of Science ®Google Scholar
• Lin L, Chow KL, Leng Y. Study of hydroxyapatite osteoinductivity with an osteogenic differentiation of mesenchymal stem cells. J Biomed Mater Res A. 2009;89(2):326–335.
   PubMed Web of Science ®Google Scholar
• Webster TJ, Ergun C, Doremus RH, et al. Enhanced functions of osteoblasts on nanophase ceramics. Biomaterials. 2000;21(17):1803–1810.
   PubMed Web of Science ®Google Scholar
• Sun H, Ye F, Wang J, et al. The upregulation of osteoblast marker genes in mesenchymal stem cells prove the osteoinductivity of hydroxyapatite/tricalcium phosphate biomaterial. Transplant Proc. 2008;40(8):2645–2648.
   PubMed Web of Science ®Google Scholar
• Balasundaram G, Webster TJ. HA coated magnetic nanoparticles for the treatment of osteoporosis. 2010;27(9).
   Google Scholar
• Honeywell M, Philips S, Vo K. Teriparatide for osteoporosis: a clinical review. Drug Forecast Citeseer. 2003;28(11):713–716.
   Google Scholar
• GEN [Internet]. c2017. New Rochelle (NY): genetic engineering & biotechnology news. Critical Pharmaceuticals, University of Nottingham to work on nano-enabled nasal spray for osteoporosis; 2012 Feb 16 [cited 2016 Nov 17]; [about 2 screens]. Available from: http://www.genengnews.com/gen-news-highlights/critical-pharmaceuticals-university-of-nottingham-to-work-on-nano-enabled-nasal-spray-for-osteoporosis/81246375/
   Google Scholar
• Huang S, Chen JC, Hsu CW, et al. Effects of nano calcium carbonate and nano calcium citrate on toxicity in ICR mice and on bone mineral density in an ovariectomized mice model. Nanotechnology. 2009; [cited 2017 Mar 29];20(37):375102. DOI: 10.1088/0957-4484/20/37/375102
   PubMed Web of Science ®Google Scholar
• Tokudome Y, Ito A, Otsuka M. Effect of zinc-containing β-tricalcium phosphate nano particles injection on jawbone mineral density and mechanical strength of osteoporosis model rats. Biol Pharm Bull. 2011;34(8):1215–1218.
   PubMed Web of Science ®Google Scholar
• Kumar A, Gupta GK, Khedgikar V, et al. In vivo efficacy studies of layer-by-layer nano-matrix bearing kaempferol for the conditions of osteoporosis: a study in ovariectomized rat model. Eur J Pharm Biopharm. 2012;82(3):508–517.
   PubMed Web of Science ®Google Scholar
• Sharan K, Siddiqui JA, Swarnkar G, et al. Role of phytochemicals in the prevention of menopausal bone loss: evidence from in vitro and in vivo, human interventional and pharmacokinetic studies. Curr Med Chem. 2009;16(9):1138–1157.
   PubMed Web of Science ®Google Scholar
• Siddiqui J, Sharan K, Swarnkar G, et al. Quercetin-6-C-β-D-glucopyranoside isolated from Ulmus wallichiana planchon is more potent than quercetin in inhibiting osteoclastogenesis and mitigating ovariectomy-induced bone loss in rats. Menopause. 2011;18(2):198–207.
   PubMed Web of Science ®Google Scholar
• Trivedi R, Kumar S, Kumar A, et al. Kaempferol has osteogenic effect in ovariectomized adult Sprague-Dawley rats. Mol Cell Endocrinol. 2008;289(1–2):85–93.
   PubMed Web of Science ®Google Scholar
• Arjmandi BH, Birnbaum R, Goyal NV, et al. Bone-sparing effect of soy protein in ovarian hormone-deficient rats is related to its isoflavone content. Am J Clin Nutr. 1998;68(6 Suppl):1364S–1368S.
   PubMed Web of Science ®Google Scholar
• Kumar A, Singh AK, Gautam AK, et al. Identification of kaempferol-regulated proteins in rat calvarial osteoblasts during mineralization by proteomics. Proteomics. 2010;10(9):1730–1739.
   PubMed Web of Science ®Google Scholar
• Powell JJ, Bruggraber SFA, Faria N, et al. A nano-disperse ferritin-core mimetic that efficiently corrects anemia without luminal iron redox activity. Nanomedicine Nanotechnology, Biol Med. 2014;10(7):1529–1538.
   PubMed Web of Science ®Google Scholar
• Prochorova AM, Pavlovb GV, Okpattah GAC. Nano-disperse iron for the treatment and prevention of iron-deficiency anemia in weaning pigs. Paper presented at: 10th Foresight Conference on Molecular Nanotechnology [Internet]. 2002 Oct 11–12. Bethesda, MD. [cited 2016 Nov 17]. Available from:https://www.foresight.org/Conference/MNT10/Abstracts/Prochorov2/index.html
   Google Scholar
• XCodex Foundation [Internet]. Heemstede (Netherlands): XCodex Foundation; c2017. Welcome to the next generation of mineral waters; 2016. [cited 2016 Nov 17]; [about 3 screens]. Available from: http://nano-mineralwater.com/nano-iron/
   Google Scholar
• Consumer Products Inventory. ColloidaLife™ Trace Minerals [Internet]. The project on emerging nanotechnologies. 2014. cited [2016 Nov 18]. Available from: http://www.nanotechproject.org/cpi/products/colloidalife-trace-minerals/
   Google Scholar
• Consumer Products Inventory. Nanogel [Internet]. The project on emerging nanotechnologies. 2013. cited [2016 Nov 18]. Available from: http://www.nanotechproject.org/cpi/products/nanogel/
   Google Scholar
• Consumer Products Inventory. Rejuvenate [Internet]. The project on emerging nanotechnologies. 2013. cited [2016 Nov 18]. Available from: http://www.nanotechproject.org/cpi/products/rejuvenate/
   Google Scholar
• Uswatta SP, Okeke IU, Jayasuriya AC. Injectable porous nano-hydroxyapatite/chitosan/tripolyphosphate scaffolds with improved compressive strength for bone regeneration. Mater Sci Eng C. 2016;69:505–512.
   PubMed Web of Science ®Google Scholar
• Chen HS, Chang JH, Wu JSB. Calcium bioavailability of nanonized pearlpowder for adults. J Food Sci. 2008;73(9):H246–H251.
   PubMed Web of Science ®Google Scholar
• Amini AR, Laurencin CT, Nukavarapu SP. Bone tissue engineering: recent advances and challenges. Crit Rev Biomed Eng. 2012;40(5):363–408.
   PubMedGoogle Scholar
• Petrovic V, Zivkovic P, Petrovic D, et al. Craniofacial bone tissue engineering. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2012;114(3):e1–e9.
   Web of Science ®Google Scholar
• Venkatesan J, Bhatnagar I, Manivasagan P, et al. Alginate composites for bone tissue engineering: a review. Int J Biol Macromol. 2015;72:269–281.
   PubMed Web of Science ®Google Scholar
• Deepthi S, Venkatesan J, Kim S-K, et al. An overview of chitin or chitosan/nano ceramic composite scaffolds for bone tissue engineering. Int J Biol Macromol. 2016;93(Pt B):1338–1353.
   PubMed Web of Science ®Google Scholar
• Mahoney C, McCullough BM, Bhattarai N, et al. Nanofibrous structure of chitosan for biomedical applications. J Nanomed Biotherap Discov. 2012; [cited 2017 Mar 29];2(1):102. DOI: 10.4172/2155-983X.1000102
   Google Scholar
• Zhao H, Jin H, Cai J. Preparation and characterization of nano-hydroxyapatite/chitosan composite with enhanced compressive strength by urease-catalyzed method. Mater Lett. 2014;116:293–295.
   Web of Science ®Google Scholar
• Chang C, Peng N, He M, et al. Fabrication and properties of chitin/hydroxyapatite hybrid hydrogels as scaffold nano-materials. Carbohydr Polym. 2013;91(1):7–13.
   PubMed Web of Science ®Google Scholar
• Manjubala I, Scheler S, Bössert J, et al. Mineralisation of chitosan scaffolds with nano-apatite formation by double diffusion technique. Acta Biomater. 2006;2(1):75–84.
   PubMed Web of Science ®Google Scholar
• Xing Ma, Yang Wang, et al. Nano-hydroxyapatite/chitosan sponge-like biocomposite for repairing of rat calvarial critical-sized bone defect. J Bioact Compat Polym. 2011;26(4):335–346.
   Web of Science ®Google Scholar
• Kong LJ, Gao Y, Lu GY, et al. A study on the bioactivity of chitosan/nano-hydroxyapatite composite scaffolds for bone tissue engineering. Eur Polym J. 2006;42(12):3171–3179.
   Web of Science ®Google Scholar
• Zou Q, Li Y, Zhang L, et al. Characterization and cytocompatibility of nano-hydroxyapatite/chitosan bone cement with the addition of calcium salts. J Biomed Mater Res - Part B Appl Biomater. 2009;90(B1):156–164.
   PubMed Web of Science ®Google Scholar
• Siripireddy B, Mandal BK, Shivendu R, et al. Nano-zirconia – Evaluation of its antioxidant and anticancer activity. J Photochem Photobiol B Biol. 2017;170:125–133.
   PubMed Web of Science ®Google Scholar
• Janardan S, Suman P, Ragul G, et al. Assessment on antibacterial activity of nanosized silica derived from hypercoordinated silicon(IV) precursors guidelines to the referees. RSC Adv. 2016;6:66394–66406.
   Web of Science ®Google Scholar
• Shivendu R, Nandita D, Srivastava P, et al. A Spectroscopic study on interaction between bovine serum albumin and titanium dioxide nanoparticle synthesized from microwave-assisted hybrid chemical approach. J Photochem Photobiol B Biol. 2016;161:472–481.
   PubMed Web of Science ®Google Scholar
• Ranjan S, Nanditha D, Chinnappan S, et al. Titanium dioxide nanoparticle-protein interaction explained by docking approach. Int J Nano. Forthcoming 2017;
   Google Scholar
• Ranjan S, Dasgupta N, Chinnappan S, et al. A novel approach to evaluate titanium dioxide nanoparticle-protein interaction through docking: an insight into mechanism of action. Proc Natl Acad Sci India. 2015; cited [2016 Nov 20]. Available from:https://link.springer.com/article/10.1007/s40011-015-0673-z
   Google Scholar
• Ranjan S, Ramalingam C. Titanium dioxide nanoparticles induce bacterial membrane rupture by reactive oxygen species generation. Environ Chem Lett. 2016;14(4):487–494.
   Web of Science ®Google Scholar
• Wei G, Ma PX. Structure and properties of nano-hydroxyapatite/polymer composite scaffolds for bone tissue engineering. Biomaterials. 2004;25(19):4749–4757.
   PubMed Web of Science ®Google Scholar
• Sharma C, Dinda AK, Potdar PD, et al. Fabrication and characterization of novel nano-biocomposite scaffold of chitosan–gelatin–alginate–hydroxyapatite for bone tissue engineering. Mater Sci Eng C. 2016;64:416–427.
   PubMed Web of Science ®Google Scholar
• Young AT, Kang JH, Kang DJ, et al. Interaction of stem cells with nano hydroxyapatite-fucoidan bionanocomposites for bone tissue regeneration. Int J Biol Macromol. 2016;93(Pt B):1488–1491.
   PubMed Web of Science ®Google Scholar
• Sowjanya JA, Singh J, Mohita T, et al. Biocomposite scaffolds containing chitosan/alginate/nano-silica for bone tissue engineering. Colloids Surfaces B Biointerfaces. 2013;109:294–300.
   PubMed Web of Science ®Google Scholar
• Correia CO, Leite ÁJ, Mano JF. Chitosan/bioactive glass nanoparticles scaffolds with shape memory properties. Carbohydr Polym. 2015;123:39–45.
   PubMed Web of Science ®Google Scholar
• Teimouri A, Ebrahimi R, Emadi R, et al. Nano-composite of silk fibroin–chitosan/Nano ZrO2 for tissue engineering applications: fabrication and morphology. Int J Biol Macromol. 2015;76:292–302.
   PubMed Web of Science ®Google Scholar
• Wers E, Oudadesse H, Lefeuvre B, et al. Evaluation of the kinetic and relaxation time of gentamicin sulfate released from hybrid biomaterial Bioglass-chitosan scaffolds. Appl Surf Sci. 2015;353:200–208.
   Web of Science ®Google Scholar
• Kavya KC, Jayakumar R, Nair S, et al. Fabrication and characterization of chitosan/gelatin/nSiO2 composite scaffold for bone tissue engineering. Int J Biol Macromol. 2013;59:255–263.
   PubMed Web of Science ®Google Scholar
• Saravanan S, Sameera DK, Moorthi A, et al. Chitosan scaffolds containing chicken feather keratin nanoparticles for bone tissue engineering. Int J Biol Macromol. 2013;62:481–486.
   PubMed Web of Science ®Google Scholar
• Serra IR, Fradique R, Vallejo MCS, et al. Production and characterization of chitosan/gelatin/β-TCP scaffolds for improved bone tissue regeneration. Mater Sci Eng C. 2015;55:592–604.
   PubMed Web of Science ®Google Scholar
• Shokri S, Movahedi B, Rafieinia M, et al. A new approach to fabrication of Cs/BG/CNT nanocomposite scaffold towards bone tissue engineering and evaluation of its properties. Appl Surf Sci. 2015;357(Part):1758–1764.
   Web of Science ®Google Scholar
• Venkatesan J, Ryu B, Sudha PN, et al. Preparation and characterization of chitosan–carbon nanotube scaffolds for bone tissue engineering. Int J Biol Macromol. 2012;50(2):393–402.
   PubMed Web of Science ®Google Scholar
• Pourhaghgouy M, Zamanian A, Shahrezaee M, et al. Physicochemical properties and bioactivity of freeze-cast chitosan nanocomposite scaffolds reinforced with bioactive glass. Mater Sci Eng C. 2016;58:180–186.
   PubMed Web of Science ®Google Scholar
• Nazemi K, Azadpour P, Moztarzadeh F, et al. Tissue-engineered chitosan/bioactive glass bone scaffolds integrated with {PLGA} nanoparticles: a therapeutic design for on-demand drug delivery. Mater Lett. 2015;138:16–20.
   Web of Science ®Google Scholar
• Jayakumar R, Ramachandran R, Kumar PTS, et al. Fabrication of chitin–chitosan/nano ZrO2 composite scaffolds for tissue engineering applications. Int J Biol Macromol. 2011;49(3):274–280.
   PubMed Web of Science ®Google Scholar
• Heidari F, Bahrololoom ME, Vashaee D, et al. In situ preparation of iron oxide nanoparticles in natural hydroxyapatite/chitosan matrix for bone tissue engineering application. Ceram Int. 2015;41(2, Part B):3094–3100.
   Web of Science ®Google Scholar
• Tripathi A, Saravanan S, Pattnaik S, et al. Bio-composite scaffolds containing chitosan/nano-hydroxyapatite/nano-copper–zinc for bone tissue engineering. Int J Biol Macromol. 2012;50(1):294–299.
   PubMed Web of Science ®Google Scholar
• Fricain JC, Schlaubitz S, Visage C Le, et al. A nano-hydroxyapatite – Pullulan/dextran polysaccharide composite macroporous material for bone tissue engineering. Biomaterials. 2013;34(12):2947–2959.
   PubMed Web of Science ®Google Scholar
• Shakir M, Jolly R, Khan MS, et al. Nano-hydroxyapatite/β-CD/chitosan nanocomposite for potential applications in bone tissue engineering. Int J Biol Macromol. 2016;93(Part A):276–289.
   PubMed Web of Science ®Google Scholar
• Lowe B, Venkatesan J, Anil S, et al. Preparation and characterization of chitosan-natural nano hydroxyapatite-fucoidan nanocomposites for bone tissue engineering. Int J Biol Macromol. 2016;93(Pt B):1479–1487.
   PubMed Web of Science ®Google Scholar
• Durgalakshmi D, Subhathirai SP, Balakumar S. Nano-bioglass: a versatile antidote for bone tissue engineering problems. Procedia Eng. 2014;92:2–8.
   Google Scholar
• Dasgupta N, Ranjan S, Rajendran B, et al. Thermal co-reduction approach to vary size of silver nanoparticle: its microbial and cellular toxicology. Env Sci Pol Res. 2016;23:4149–4163.
   PubMed Web of Science ®Google Scholar
• Ranjan S, Dasgupta N, Rajendran B, et al. Microwave-irradiation-assisted hybrid chemical approach for titanium dioxide nanoparticle synthesis: microbial and cytotoxicological evaluation. Env Sci Pollut Res. 2016;23(12):12287–12302.
   PubMed Web of Science ®Google Scholar
• Dasgupta N, Ramalingam C. Silver nanoparticle antimicrobial activity explained by membrane rupture and reactive oxygen generation. Environ Chem Lett. 2016;14(4):477–485.
   Web of Science ®Google Scholar
• Sireesh BM, Mandal BK, Ranjan S, et al. Diastase assisted green synthesis of size- controllable gold nanoparticles. RSC Adv. 2015;5:26727–26733.
   Web of Science ®Google Scholar
• Babu Maddinedi S, Kumar Mandal B, Patil SH, et al. Diastase induced green synthesis of bilayered reduced graphene oxide and its decoration with gold nanoparticles. J Photochem Photobiol B. 2017;166:252–258.
   PubMed Web of Science ®Google Scholar
• Tammina SK, Mandal BK, Ranjan S, et al. Cytotoxicity study of Piper nigrum seed mediated synthesized SnO2 nanoparticles towards colorectal (HCT116) and lung cancer (A549) cell lines. J Photochem Photobiol B Biol. 2017;166:158–168.
   PubMed Web of Science ®Google Scholar
• Sanhai WR, Sakamoto JH, Canady R, et al. Seven challenges for nanomedicine. Nat Nanotechnol. 2008;3(5):242–244.
   PubMed Web of Science ®Google Scholar
• Bamrungsap S, Zhao Z, Chen T, et al. Nanotechnology in therapeutics: a focus on nanoparticles as a drug delivery system. Nanomed Future Med. 2012;7(8):1253–1271.
   PubMed Web of Science ®Google Scholar
• Sahoo KB, Pattajoshi SP. Challenges of nano drug delivery and its safety issues. Int J Pharm Pharm Res. 2016; [cited 2017 Mar 29];6(3): Available from:http://ijppr.humanjournals.com/wp-content/uploads/2016/07/42.Bijay-Kumar-Sahoo-Sidheswar-Prasad-Pattajoshi.pdf
   Google Scholar
• Hobson DW, Roberts SM, Shvedova AA, et al. Applied Nanotoxicology. Int J Toxicol. 2016;35(1):5–16.
   PubMed Web of Science ®Google Scholar
• Jain A, Shivendu R, Nandita D, et al. Nanomaterials in Food and Agriculture: an overview on their safety concerns and regulatory issues. Crit Rev Food Sci Nutr. Forthcoming 2017; DOI: 10.1080/10408398.2016.1160363
   PubMed Web of Science ®Google Scholar
• Kisin ER, Murray AR, Keane MJ, et al. Single-walled carbon nanotubes: geno- and cytotoxic effects in lung fibroblast V79 cells. J Toxicol Environ Health A. 2007;70:2071–2079.
   PubMed Web of Science ®Google Scholar
• Barnes CA, Elsaesser A, Arkusz J, et al. Reproducible comet assay of amorphous silica nanoparticles detects no genotoxicity. Nano Lett. 2008;8:3069–3074.
   PubMed Web of Science ®Google Scholar
• Deng ZJ, Liang M, Monteiro M, et al. Nanoparticle-induced unfolding of fibrinogen promotes Mac-1 receptor activation and inflammation. Nat Nanotechnol. 2011;6(1):39–44.
   PubMed Web of Science ®Google Scholar