Safflower yellow extract inhibits thrombus formation in mouse brain arteriole and exerts protective effects against hemorheology disorders in a rat model of blood stasis syndrome

References

• Meng C, Zhao PW, Sun YL. Advances in pharmacological function of Carthamus tinctorius and its essential constitutes. Global Trad Chin Med. 2012;5(7):556–560.
   Google Scholar
• Yang L, Wang L, Yao M, et al. The effectiveness and safety of edaravone combined with safflower yellow injections for the treatment of acute cerebral infarction: a meta-analysis. Chin J Clin Res. 2013;26(4):313–316.
   Google Scholar
• Zhou X, Tang L, Xu Y, et al. Towards a better understanding of medicinal uses of Carthamus tinctorius L. in traditional Chinese medicine: a phytochemical and pharmacological review. J Ethnopharmacol. 2014;151(1):27–43.
   PubMed Web of Science ®Google Scholar
• Yang XW, Li YH, Zhang H, et al. Safflower Yellow regulates microglial polarization and inhibits inflammatory response in LPS-stimulated Bv2 cells. Int J Immunopathol Pharmacol. 2016;29(1):54–64.
   PubMed Web of Science ®Google Scholar
• Liu Y, Lian Z, Zhu H, et al. A systematic, integrated study on the neuroprotective effects of hydroxysafflor yellow A revealed by (1) H NMR-based metabonomics and the NF-kappaB pathway. Evid Based Complement Alternat Med. 2013.
   Web of Science ®Google Scholar
• Bai Y, Lu P, Han C, et al. Hydroxysafflor yellow A (HSYA) from flowers of Carthamus tinctorius L. and its vasodilatation effects on pulmonary artery. Molecules. 2012;17(12):14918–14927.
   PubMed Web of Science ®Google Scholar
• Wang Y, Zhang C, Peng W, et al. Hydroxysafflor yellow A exerts antioxidant effects in a rat model of traumatic brain injury. Mol Med Rep. 2016;(14):3690–3696.
   PubMedGoogle Scholar
• Yang F, Li J, Zhu J, et al. Hydroxysafflor yellow A inhibits angiogenesis of hepatocellular carcinoma via blocking ERK/MAPK and NF-kappaB signaling pathway in H22 tumor-bearing mice. Eur J Pharmacol. 2015;754:105–114.
   PubMed Web of Science ®Google Scholar
• Whinna HC. Overview of murine thrombosis models. Thromb Res. 2008;122:S64–S69.
   PubMed Web of Science ®Google Scholar
• Liu H, Zhang W-J, Long C-F, et al. Protective effects of traditional Chinese herbal formula Compound Xueshuantong Capsule (CXC) on rats with blood circulation disorders. Biotechnol Biotechnol Equip. 2017;31(4):846–854.
   Web of Science ®Google Scholar
• Zhang Q, Lan Y, He X-f, et al. Allopurinol protects against ischemic insults in a mouse model of cortical microinfarction. Brain Res. 2015;1622:361–367.
   PubMed Web of Science ®Google Scholar
• Li P, Su W, Yun S, et al. Toward a scientific understanding of the effectiveness, material basis and prescription compatibility of a Chinese herbal formula Dan-hong injection. Sci Rep. 2017;7:46266.
   PubMed Web of Science ®Google Scholar
• Murphy TH. Two-photon imaging of neuronal structural plasticity in mice during and after Ischemia. Cold Spring Harb Protoc. 2015;2015(6):941–952.
   PubMedGoogle Scholar
• Liu H, JP L, Li P, et al. Core bioactive components promoting blood circulation in the Traditional Chinese Medicine Compound Xueshuantong Capsule (CXC) based on the relevance analysis between chemical HPLC fingerprint and in vivo biological effects. PLoS One. 2014;9(11):e112675.
   PubMed Web of Science ®Google Scholar
• Jin Y, Zhang XL, Shi H, et al. Characterization of C-glycosyl quinochalcones in Carthamus tinctorius L. by ultraperformance liquid chromatography coupled with quadrupole-time-of-flight mass spectrometry. Rapid Commun Mass Spectrom. 2008;22(8):1275–1287.
   PubMed Web of Science ®Google Scholar
• Fan L, Guo D-A. Stability and degradation of hydroxysafflor yellow A and anhydrosafflor yellow B in the safflower injection studied by HPLC-DAD-ESI-MSn. J Chin Pharm Sci. 2011;20(1).
   Google Scholar
• Shang E, Zhu Z, Liu L, et al. UPLC-QTOF-MS with chemical profiling approach for rapidly evaluating chemical consistency between traditional and dispensing granule decoctions of Tao-Hong-Si-Wu decoction. Chem Cent J. 2012;6(1):143.
   PubMedGoogle Scholar
• Perez P, Alarcon M, Fuentes E, et al. Thrombus formation induced by laser in a mouse model. Exp Ther Med. 2014;8(1):64–68.
   PubMed Web of Science ®Google Scholar
• Kamocka MM, Mu J, Liu X, et al. Two-photon intravital imaging of thrombus development. J Biomed Opt. 2010;15(1):016020.
   PubMed Web of Science ®Google Scholar
• Bochenek ML, Schütz E, Schäfer K. Endothelial cell senescence and thrombosis: ageing clots. Thromb Res. 2016;147:36–45.
   PubMed Web of Science ®Google Scholar
• Li Y, Shi Y, Sun Y, et al. Restorative effects of hydroxysafflor yellow A on hepatic function in an experimental regression model of hepatic fibrosis induced by carbon tetrachloride. Mol Med Rep. 2017;15(1):47–56.
   PubMed Web of Science ®Google Scholar
• Wright B, Moraes LA, Kemp CF, et al. A structural basis for the inhibition of collagen-stimulated platelet function by quercetin and structurally related flavonoids. Br J Pharmacol. 2010;159(6):1312–1325.
   PubMed Web of Science ®Google Scholar
• Yu L, Hu G-Q, Du X, et al. Inhibition of cerebral ischemia/reperfusion injury-induced apoptosis: nicotiflorin and JAK2/STAT3 pathway. Neural Regen Res. 2017;12(1):96.
   PubMed Web of Science ®Google Scholar
• Li HX, Han SY, Wang XW, et al. Effect of the carthamins yellow from Carthamus tinctorius L. on hemorheological disorders of blood stasis in rats. Food Chem Toxicol. 2009;47(8):1797–802.
   PubMed Web of Science ®Google Scholar
• Cowan AQ, Cho DJ, Rosenson RS. Importance of blood rheology in the pathophysiology of atherothrombosis. Cardiovasc Drugs Ther. 2012;26(4):339–48.
   PubMed Web of Science ®Google Scholar
• Wang K, Yang L. Analysis of 192 cases of traditional Chinese medicine and its adverse drug reaction. China Health Standard Manage. 2016;7:164–166.
   Google Scholar