Current bioeconomical interest in stramenopilic Eustigmatophyceae: a review

References

• Zawojska A, Siudek T. Bioeconomics as interdisciplinary science. Proceedings of the 2016 International Conference “Economic science for rural development” 41; 2016 April 21–22; Jelgava, LLU ESAF; 2016. p. 273–280.
   Google Scholar
• European Commission Innovating for sustainable growth: A Bioeconomy for Europe. Luxembourg: Publication Office of the European Union. 2012;64.
   Google Scholar
• Wilkie C, Edmundson SJ, Duncan JG. Indigenous algae for local bioresource production: Phycoprospecting. Energy Sustain Dev. 2011;15:365–371.
   Web of Science ®Google Scholar
• Senhorincho GNA, Laamanen CA, Scott JA. Bioprospecting freshwater microalgae for antibacterial activity from water bodies associated with abandoned mine sites. Phycologia. 2018;57:432–439.
   Web of Science ®Google Scholar
• Patil V, Tran KQ, Giselrød HR. Towards sustainable production of biofuels from microalgae. Int J Mol Sci. 2008;9:1188–1195.
   PubMed Web of Science ®Google Scholar
• Khan S, Siddique R, Sajjad W. Biodisel production from algae to overcome the energy crisis. Hayyati J Biosci. 2017;24:163–167.
   Google Scholar
• Slocombe SP, Zhang Q, Ross M, et al. Unlocking nature's treasure-chest: screening for oleaginous algae. Sci Rep. 2015;5:9844.
   PubMed Web of Science ®Google Scholar
• Murakami H, Nobusawa T, Hori K, et al. Betaine lipid is crucial for adapting to low temperature and phosphate deficiency in Nannochloropsis. Plant Physiol. 2018;177:181–193.
   PubMed Web of Science ®Google Scholar
• Antia NJ, Cheng JY. The keto-carotenoids of two marine coccoid members of the Eustigmatophyceae. Br Phycol J. 1982;17:39–50.
   Web of Science ®Google Scholar
• Hager A, Stransky H. Das Carotinoidmuster und der Verbreitung des lichtinduzierten Xanthophyllcyclus in verschiedenen Algenklassen. III. Archiv Mikrobiol. 1970;72:68–83.
   PubMedGoogle Scholar
• Lubián LM, Montero O, Moreno-Garrido I, et al. Nannochloropsis (Eustigmatophyceae) as source of commercially valuable pigments. J Appl Phycol. 2000;12:249–255.
   Web of Science ®Google Scholar
• Stoyneva-Gärtner MP, Stoykova P, Uzunov B, et al. Carotenoids in five aeroterrestrial strains from Vischeria/Eustigmatos group: Updating the pigment pattern of Eustigmatophyceae. Biotechnol Biotechnol Equip. 2019;1. 19p. doi: 10.1080/13102818.2018.1562984.
   Web of Science ®Google Scholar
• Higuera-Ciapara I, Félix-Valenzuela L, Goycoolea FM. Astaxanthin: A review of its chemistry and applications. Crit Rev Food Sci Nutr. 2006;46:185–196.
   PubMed Web of Science ®Google Scholar
• Ambati RR, Siew-Moi P, Sarada R, et al. Astaxanthin: Sources, extraction, stability, biological activities and its commercial applications - A review. Mar Drugs. 2014;12:128–152.
   PubMed Web of Science ®Google Scholar
• Shah MM, Liang Y, Cheng JJ, et al. Astaxanthin-producing green microalga Haematococcus pluvialis: from single cell to high value commercial products. Front Plant Sci. 2016;7:531.
   PubMed Web of Science ®Google Scholar
• European register of food additives pursuant to Regulation (EC) No 1831/2003. Annex II. Luxembourg: Publication office of European Union. 2018;
   Google Scholar
• Summary of Color Additives for Use in the United States in Foods, Drugs, Cosmetics, and Medical Devices. USA Food and Drug Administration; [cited 2011 Oct 27]. Available from: https://www.fda.gov/ForIndustry/ColorAdditives/ColorAdditiveInventories/ucm115641.htm
   Google Scholar
• Color Additive Status List. List 4. USA Food and Drug Administration; [cited 2011 Oct 27]. Available from: https://www.fda.gov/ForIndustry/ColorAdditives/ColorAdditiveInventories/ucm106626.htm
   Google Scholar
• Astaxanthin wins full GRAS status. FDA [cited 2010 Jan 19]. Available from: https://www.nutraingredients-usa.com/Article/2010/01/19/Astaxanthin-wins-full-GRAS-status
   Google Scholar
• Park JS, Chyun JH, Kim YK, et al. Astaxanthin decreased oxidative stress and inflammation and enhanced immune response in humans. Nutr Metab (Lond). 2010;7:18–28.
   PubMed Web of Science ®Google Scholar
• McCall BCK, McPartland R, Moore A, et al. Effects of astaxanthin on the proliferation and migration of breast cancer cells in vitro. Antioxidants. 2018;7:135–143.
   Web of Science ®Google Scholar
• Li Z, Sun M, Li Q, et al. Profiling of carotenoids in six microalgae (Eustigmatophyceae) and assessment of their β-carotene productions in bubble column photobioreactor. Biotechnol Lett. 2012;34:2049–2053.
   PubMed Web of Science ®Google Scholar
• Li Z, Ma XQ, Li AF, et al. A novel potential source of β-carotene: Eustigmatos cf. polyphem (Eustigmatophyceae) and pilot β-carotene production in bubble column and flat panel photobioreactors. Bioresour Technol. 2012;117:257–263.
   PubMed Web of Science ®Google Scholar
• EU approved additives and E Numbers. UK Food Standards Agency; [2018]. Available from: https://www.food.gov.uk/business-guidance/eu-approved-additives-and-e-numbers
   Google Scholar
• Prieto A, Pedro Canãvate JP, García-González M. Assessment of carotenoid production by Dunaliella salina in different culture systems and operation regimes. J Biotechnol. 2011;151:180–185.
   PubMed Web of Science ®Google Scholar
• Gao B, Yang J, Lei X, et al. Characterization of cell structural change, growth, lipid accumulation, and pigment profile of a novel oleaginous microalga, Vischeria stellata (Eustigmatophyceae), cultured with different initial nitrate supplies. J Appl Phycol. 2016;28:821–830.
   Web of Science ®Google Scholar
• Food additive status list. US Food and Drug Administration; [cited 2018 Apr 01]. Available from: https://www.fda.gov/food/ingredientspackaginglabeling/foodadditivesingredients/ucm091048.htm#ftnV
   Google Scholar
• Talero E, García-Mauriño S, Ávila-Román A, et al. Bioactive compounds isolated from microalgae in chronic inflammation and cancer. Mar Drugs. 2015;13:6152–6209.
   PubMed Web of Science ®Google Scholar
• Wang F, Huang L, Gao B, et al. Optimum production conditions, purification, identification, and antioxidant activity of violaxanthin from microalga Eustigmatos cf. polyphem (Eustigmatophyceae). Mar Drugs. 2018;16:190.
   Web of Science ®Google Scholar
• FDA-3 Agency Additional Correspondence Letter GRAS Notice No. GRN 000140 of 29th July 2016
   Google Scholar
• Miranda JM, Anton X, Redondo-Valbuena C, et al. Egg and egg-derived foods: Effects on human health and use as functional foods. Nutrients. 2015;7:706–729.
   PubMed Web of Science ®Google Scholar
• Li B, Vachali P, Bernstein PS. Human ocular carotenoid-binding proteins. Photochem Photobiol Sci. 2010; 9:1418–1425.
   PubMed Web of Science ®Google Scholar
• Nolan JM, Meagher K, Kashani S, et al. What is meso-zeaxanthin, and where does it come from?. Eye (Lond). 2013;27:899–905.
   PubMed Web of Science ®Google Scholar
• Koo E, Neuringer M, Sangiovanni JP. Macular xanthophylls, lipoprotein-related genes, and age-related macular degeneration. Amer J Clinic Nutr. 2014;100:336S–346S.
   PubMed Web of Science ®Google Scholar
• Pinazo-Durán MD, Gómez-Ulla F, Arias L, et al. Do nutritional supplements have a role in age macular degeneration prevention?. J Ophthalmol. 2014;2014:901686.
   PubMedGoogle Scholar
• Wang X, Jiang C, Zhang Y, et al. Role of lutein supplementation in the management of age-related macular degeneration: meta-analysis of randomized controlled trials. Ophthalmic Res. 2014;52:198–205.
   PubMed Web of Science ®Google Scholar
• Bernstein PS, Li B, Vachali PP, et al. Lutein, zeaxanthin, and meso-zeaxanthin: The basic and clinical science underlying carotenoid-based nutritional interventions against ocular disease. Prog Retin Eye Res. 2016;50:34–66.
   PubMed Web of Science ®Google Scholar
• Yu B, Wang J, Suter PM, et al. Spirulina is an effective dietary source of zeaxanthin to humans. Br J Nutr. 2012;108:611–619.
   PubMed Web of Science ®Google Scholar
• EFSA. Opinion of the Scientific Panel on additives and products or substances used in animal feed on the request from the European Commission on the safety of use of colouring agents in animal nutrition. EFSA J. 2005;291:1–40.
   Google Scholar
• Brizio P, Benedetto A, Righetti M, et al. Astaxanthin and canthaxanthin (xanthophyll) as supplements in rainbow trout diet: in vivo assessment of residual levels and contributions to human health. J Agric Food Chem. 2013;61:10954–10959.
   PubMed Web of Science ®Google Scholar
• Choubert G, de la Noüe J, Blanc JM. Apparent digestibility of canthaxanthin in rainbow trout: effect of dietary fat level, antibiotics and number of pyloric caeca. Aquaculture. 1991;99:323–329.
   Web of Science ®Google Scholar
• Choubert G, Storebakken T. Digestibility of astaxanthin and canthaxanthin in rainbow trout as affected by dietary concentration, feeding rate and water salinity. Ann Zootech. 1996; 45:445–453.
   Google Scholar
• Niu J, Li CH, Liu YJ, et al. Dietary values of astaxanthin and canthaxanthin in Penaeus monodon in the presence and absence of cholesterol supplementation: effect on growth, nutrient digestibility and tissue carotenoid composition. Br J Nutr. 2012;108:80–91.
   PubMed Web of Science ®Google Scholar
• Surai AP, Surai PF, Steinberg W, et al. Effect of canthaxanthin content of the maternal diet on the antioxidant system of the developing chick. Br Poult Sci. 2003;44:612–619.
   PubMed Web of Science ®Google Scholar
• Surai PF. The antioxidant properties of canthaxanthin and its potential effects in the poultry eggs and on embryonic development of the chick. Part 1. Worlds Poult Sci J. 2012;68:465–476.
   Web of Science ®Google Scholar
• Surai PF. The antioxidant properties of canthaxanthin and its potential effects in the poultry eggs and on embryonic development of the chick. Part 2. Worlds Poult Sci J. 2012;68:717–726.
   Web of Science ®Google Scholar
• Rosa AP, Scher A, Sorbara JO, et al. Effects of canthaxanthin on the productive and reproductive performance of broiler breeders. Poult Sci. 2012;91:660–666.
   PubMed Web of Science ®Google Scholar
• Sujak A, Gabrielska J, Milanowska J, et al. Studies on canthaxanthin in lipid membranes. Biochim Biophys Acta. 2005;1712:17–28.
   PubMed Web of Science ®Google Scholar
• Koller M, Muhr A, Braunegg G. Microalgae as versatile cellular factories for valued products. Algal Res. 2014;6:52–63.
   Google Scholar
• Mourelle ML, Gómez CP, Legido JL. The potential use of marine microalgae and Cyanobacteria in cosmetics and thalassotherapy. Cosmetics. 2017; 4:46.
   Google Scholar
• Eid SY, El-Readi MZ, Wink M. Carotenoids reverse multidrug resistance in cancer cells by interfering with ABC-transporters. Phytomedicine. 2012;19:977–978.
   PubMed Web of Science ®Google Scholar
• Braun R, Farré E, Schurr U, et al. Effects of light and circulation clock on growth and chlorophyll accumulation of Nannochloropsis gaditana (Eustigmatophyte). J Phycol. 2014; 50:515–525.
   PubMedGoogle Scholar
• Mishra VK, Bacheti RK, Husen A. 2011. Medicinal uses of chlorophyll: A critical overview. In: Le H, Salcedo E, editors. Chlorophyll: structure, function and medicinal uses. Hauppauge (NY): Nova Science Publishers; 2011. p. 177–196.
   Google Scholar
• McGee H. On food and cooking. The science and lore of the kitchen. New York: Scribner; 2004.
   Google Scholar
• Chlorophyll [cited 2019 Jan 09]. Available from: https://en.wikipedia.org/wiki/Chlorophyll
   Google Scholar
• Kakhia TI. Dyes, Colors & Pigments. 2015. Available from: http://tarek.kakhia.org.
   Google Scholar
• Durmaz Y. Vitamin E (α-tocopherol) production by the marine microalgae Nannochloropsis oculata (Eustigmatophyceae) nutrient limitation. Aquaculture. 2007;272:711–722.
   Web of Science ®Google Scholar
• Goh LP, Loh SP, Fatimah MY, et al. Bioaccessibility of carotenoids and tocopherols in marine Microalgae, Nannochloropsis sp. and Chaetoceros sp. Malays J Nutr. 2009;15:77–86.
   PubMedGoogle Scholar
• Liu C-P, Lin L-P. Morphology and eicosapentaenoic acid production by Monodus subterraneus UTEX 151. Micron. 2005;36:545–550.
   PubMed Web of Science ®Google Scholar
• Spolaore P, Joannis-Cassan C, Duran E, et al. Commercial applications of microalgae. J Biosci Bioeng. 2006;101:87–96.
   PubMed Web of Science ®Google Scholar
• Fukusho K. Biology and mass production of the rotifer Brachiolnus plicatilis. Int J Aguatic Fish Technol. 1989;1:232–240.
   Google Scholar
• Yúfera M, Navarro N. Population dynamics on the rotifer Brachionus plicatilis cultured in non-limiting food consumption. Hydrobiologia. 1995;313-314:399–405.
   Web of Science ®Google Scholar
• Kostopolou V, Vadstein O. Growth performance of the rotifer Brachiolnus plicatilis, B. “Nevada” and B. “Cayman” under different food concentrations. Aquaculture. 2007; 273:449–458.
   Web of Science ®Google Scholar
• Campaña-Torres AL, Martínez-Córdova LR, Martínez-Porchas M, et al. Productive response of Nannochloropsis oculata, cultured in different media and their efficiency as food for the rotifer Brachionus rotundiformis. FHYTON. 2012;81:45–50.
   Google Scholar
• Ferreira M, Coutinho P, Seixas P, et al. Enriching rotifers with “premium” microalgae. Nannochloropsis gaditana. Mar Biotechnol. 2009;11:585–595.
   PubMed Web of Science ®Google Scholar
• Bae JB, Hur SB. Selection of suitable species of Chlorella, Nannochloris, and Nannochloropsis in high- and low-temperature seasons for mass culture of the rotifer Brachionus plicatilis. Fish Aquat Sci. 2011;14:323–332.
   Google Scholar
• Fui CF, Cancerini SY, Shapawi R, et al. Comparison of Nannochloropsis oculata productions cultivated in two different systems: outdoor Red Tilapia (Oreochromis sp.) culture tank and indoor pure culture. Pertanika J Trop Agric Sci. 2018;41:1523–1531.
   Google Scholar
• Chen HS, Li SS, Huang R, et al. Conditional production of a functional fish growth hormone in the transgenic line of Nannochloropsis oculata (Eustigmatophyceae). J Phycol. 2008;44:768–776.
   PubMed Web of Science ®Google Scholar
• Patterson GW, Tsitsa-Tzardis E, Wikfors GH, et al. Sterols of Eustigmatophyceae. Lipids. 1994; 29:661–664.
   PubMedGoogle Scholar
• Mercer EI, London RA, Kent IS, et al. Sterols, sterol esters and fatty acids of Botrydium granulatum, Tribonema aequale and Monodus subterraneus. Phytochem. 1974;13:845–852.
   Web of Science ®Google Scholar
• Sanjeewa KKA, Fernando IPS, Samarakoon KW, et al. Anti-inflammatory and anti-cancer activities of sterol rich fraction of cultured marine microalga Nannochloropsis oculata. Algae. 2016;31:277–287.
   Web of Science ®Google Scholar
• Suen Y, Hubbard JS, Holzer G, et al. Total lipid production of the green algal genus Nannochloropsis sp. QII under different nitrogen regimes. J Phycol. 1987;23:289–296.
   Web of Science ®Google Scholar
• Volkman JK, Barrett SM, Dunstan GA, et al. C30-C32 alkyl diols and unsaturated alcohols in microalgae of class Eustigmatophyceae. Org Geochem. 1992;18:131–138.
   Web of Science ®Google Scholar
• Ristić-Medić D, Vučić V, Takić M, et al. Polyunsaturated fatty acids in health and disease. J. Serb. Chem. Soc. 2013;78:1269–1289.
   Web of Science ®Google Scholar
• Honoré E, Barhanin J, Attali B, et al. External blockade of the major cardiac delayed-rectifier K + channel (Kv1.5) by polyunsaturated fatty acids. Proc Natl Acad Sci. 1994;91:1937–1941.
   PubMed Web of Science ®Google Scholar
• Simopoulos AP. Omega-3 fatty acids in health and disease and in growth and development. Am J Clin Nutr. 1991;54:438–463.
   PubMed Web of Science ®Google Scholar
• Herbaut C. Omega-3 and health. Rev Médic Bruxelles. 2006;27:S355–S360.
   PubMedGoogle Scholar
• Landmark K, Alm CS. Alpha-linolenic acid, cardiovascular disease and sudden death. Tidsskr Nor Laegeforen. 2006;126:2792–2794.
   PubMedGoogle Scholar
• Reiffel JA, McDonald A. Antiarrhythmic effects of omega-3 fatty acids. Am J Cardiol. 2006;98:50i–60i.
   PubMed Web of Science ®Google Scholar
• Kruger MC, Horrobin DF. Calcium metabolism, osteoporosis and essential fatty acids: a review. Prog Lipid Res. 1997;36:131–151.
   PubMed Web of Science ®Google Scholar
• Pilatova J. The Potential Use of the Eustigmatophyceae in the Production of Biofuels [master’s thesis]. Praha: Charles University; 2013.
   Google Scholar
• Seto A, Wang HL, Hesseltine CW. Culture conditions affect eicasapentanoic acid content of Chlorella minutissima. J Amer Oil Soc. 1984;61:891–894.
   Web of Science ®Google Scholar
• Sukenik A, Carmeli Y, Berner T. Regulation of fatty acid composition by irradiance level in the eustigmatophyte Nannochloropsis sp. J Phycol. 1989;25:686–692.
   Web of Science ®Google Scholar
• Rebolloso-Fuentes MM, Navarro-Pérez A, Garcia-Camacho F, et al. Biomass nutrient profiles of the microalga Nannochloropsis. J Agric Food Chem. 2001;49:2966–2972.
   PubMed Web of Science ®Google Scholar
• Safafar H, Michael ZH, Møller P, et al. High-EPA biomass from Nannochloropsis salina cultivated in a flat-panel photo-bioreactor on a process water-enriched growth medium. Mar Drugs. 2016;14:144.
   Web of Science ®Google Scholar
• Neumann UF, Derwenskus A, Gille S, et al. Bioavailability and safety of nutrients from the microalgae Chlorella vulgaris, Nannochloropsis oceanica and Phaeodactylum tricornutum in C57BL/6 mice. Nutrients. 2018;10:965.
   Web of Science ®Google Scholar
• Hodgson PA, Henderson RJ, Sargent JR, et al. Patterns of variation in the lipid class and fatty acid composition of Nannochloropsis oculata (Eustigmatophyceae) during batch culture. J Appl Phycol. 1991;3:169–181.
   Web of Science ®Google Scholar
• Sukenik A, Carmeli Y. Lipid synthesis and fatty acid composition in Nannochloropsis sp. (Eustigmatophyceae) grown in a light-dark cycle. J Phycol. 1990;469:463–469.
   Google Scholar
• Sukenik A. Ecophysiological considerations in the optimization of eicosapentanoic acid production by Nannochloropsis sp. (Eustigmatophyceae). Biores Technol. 1991;35:263–269.
   Web of Science ®Google Scholar
• Cohen Z. Production potential of eicosapentaenoic acid by Monodus subterraneus. J Am Oil Chem Soc. 1994;71:941–945.
   Web of Science ®Google Scholar
• Cohen Z. Monodus subterraneus. In: Cohen Z, editor. Chemicals from microalgae. London: CRC Press; 1999. p. 25–40.
   Google Scholar
• Zou N, Zang C, Cohen Z, et al. Production of cell mass and eicosapentanoic acid (EPA) inultrahigh cell density cultures of Nannochloropsis sp. (Eustigmatophyceae). Eur J Phycol. 2000;35:122–133.
   Google Scholar
• Xuecheng XNZ. Effect of temperature, light intensity and pH on the growth and fatty acid compositions of Ellipsoidion sp. J Ocean Univ Qingdao. 2001;4:013–023.
   Google Scholar
• Hu H, Gao K. Optimization of growth and fatty acid composition of a unicellular marine picoplankton, Nannochloropsis sp., with enriched carbon sources. Biotechnol Lett. 2003; 25:421–425.
   PubMed Web of Science ®Google Scholar
• Tonon T, Harvey D, Larson TR, et al. Long chain polyunsaturated fatty acid production and partitioning to triacylglycerols in four microalgae. Phytochem. 2002;61:15–24.
   PubMed Web of Science ®Google Scholar
• Xu F, Hu H, Cong W, et al. Growth characteristics and eicosapentaenoic acid production by Nannochloropsis sp. in mixotrophic conditions. Biotechnol Lett. 2004;26:51–53.
   PubMed Web of Science ®Google Scholar
• Converti A, Casazza AA, Ortiz EY, et al. Effect of temperature and nitrogen concentration on the growth and lipid content of Nannochloropsis oculata and Chlorella vulgaris for biodiesel production. Chem Eng Process: Process Intensific. 2009;48:1146–1151.
   Web of Science ®Google Scholar
• Hoffmann M, Marxen K, Schulz R, et al. TFA and EPA productivities of Nannochloropsis salina influenced by temperature and nitrate stimuli in turbidostatic controlled experiments. Mar Drugs. 2010;8:2526–2545.
   PubMed Web of Science ®Google Scholar
• Pal D, Khozin-Goldberg I, Cohen Z, et al. The effect of light, salinity, and nitrogen availability on lipid production by Nannochloropsis sp. Appl Microbiol Biotechnol. 2011;90:1429–1441.
   PubMed Web of Science ®Google Scholar
• Lin Q, Gu N, Li G, et al. Effects of inorganic carbon concentration on carbon formation, nitrate utilization, biomass and oil accumulation of Nannochloropsis oculata CS 179. Biores Technol. 2012;111:353–359.
   PubMed Web of Science ®Google Scholar
• Recht L, Zarka A, Boussiba S. Patterns of carbohydrate and fatty acid changes under nitrogen starvation in the microalgae Haematococcus pluvialis and Nannochloropsis sp. Appl Microbiol Biotechnol. 2012;94:1495–1503.
   PubMed Web of Science ®Google Scholar
• Simionato D, Sforza E, Corteggiani Carpinelli E, et al. Acclimation of Nannochloropsis gaditana to different illumination regimes: effects on lipids accumulation. Biores Technol. 2011;102:6026–6032.
   PubMed Web of Science ®Google Scholar
• Arudchelvam Y, Nirmalakhandan N. Energetic optimization of algal lipid production in bubble columns: Part 1: Evaluation of gas sparging. Biomass Bioenergy. 2012;46:757–764.
   Web of Science ®Google Scholar
• Arudchelvam Y, Nirmalakhandan N. Energetic optimization of algal lipid production in bubble columns: Part II: Evaluation of CO2 enrichment. Biomass Bioenergy. 2012;46:765–772.
   Web of Science ®Google Scholar
• Iwai M, Hori K, Sasaki-Sekimoto Y, et al. Manipulation of oil synthesis in Nannochloropsis strain NIES-2145 with a phosphorus starvation-inducible promoter from Chlamydomonas reinhardtii. Front Microbiol. 2015;6:912.
   PubMed Web of Science ®Google Scholar
• Falkowski PG. Potential strategies for regulating the flux of carbon into specific chemical classes of algae. In: Ramos, J Jones MC, editors. Polysaccharides from microalgae: A new agroindustry. Proceedings of the International Workshop DUML. Beaufort (NC); 1988. p. 83–91.
   Google Scholar
• Chatuverdi R, Uppalapati SR, Alamsjash MA, et al. Isolation of quizalofop-resistant mutants of Nannochloropsis oculata (Eustigmatophyceae) with high eicosapentanoic acid following N-methyl-N-nitrosourea-induced random mutagenesis. J Appl Phycol. 2004;16:135–144.
   Web of Science ®Google Scholar
• Zhang J, Liu S, Sun X, et al. Fatty acid composition analyses of DCMU resistant mutants of Nannochloropsis oculata (Eustigmatophyceae). J Ocean Univ Qindao. 2003;2:63–68.
   Google Scholar
• Cañavate JP, Armada I, Hachero-Cruzado I, et al. Interspecific variability in phosphorus induced lipid remodelling among marine eukaryotic phytoplankton. New Phytol. 2017;213:700–713.
   PubMed Web of Science ®Google Scholar
• Dolch LJ, Rak C, Perin G, et al. A palmitic acid elongase affects eicosapentaenoic acid and plastidial monogalactosyldiacylglycerol levels in Nannochloropsis. Plant Physiol. 2017;173:742–759.
   PubMed Web of Science ®Google Scholar
• Nobusawa T, Hori K, Mori H, et al. Differently localized lysophosphatidic acid acyltransferases crucial for triacylglycerol biosynthesis in the oleaginous alga Nannochloropsis. Plant J. 2017;90:547–559.
   PubMed Web of Science ®Google Scholar
• Iwamoto H, Sato S. Production of EPA by freshwater unicellular algae. J Amer Oil Chem Soc. 1986;63:434–440.
   Web of Science ®Google Scholar
• Hu Q, Hu Z, Zvi C, et al. Enhancement of eicosapentaenoic acid (EPA) and J-linolenic acid (GLA) production by manipulating algal density of outdoor cultures of Monodus subterraneus (Eustigmatophyta) and Spirulina platensis (Cyanobacteria). Eur J Phycol. 1997;32:81–86.
   Web of Science ®Google Scholar
• Vazhappilly R, Chen F. Eicosapentaenoic acid and docosahexaenoic acid production potential of microalgae and their heterotrophic growth. J Amer Oil Chem Soc. 1998;75:393–397.
   Web of Science ®Google Scholar
• Volkman JK, Barrett SM, Blackburn SI. Fatty acids and hydrocy fatty acids in three species of freshwater eustigmatophytes. J Phycol. 1999;35:1005–1012.
   Web of Science ®Google Scholar
• Xu N, Zhang X, Fan X, et al. Effects of nitrogen source and concentration on growth rate and fatty acid composition of Ellipsoidion sp. (Eustigmatophyta). J Appl Phycol. 2001;13:463–469.
   Web of Science ®Google Scholar
• Khozin-Goldberg I, Didi-Cohen S, Shayakhmetova I, et al. Biosynthesis of eicosapentaenoic acid (EPA) in the freshwater eustigmatophyte Monodus subterraneus (Eustigmatophyceae) 1. J Phycol. 2002;38:745–756.
   Web of Science ®Google Scholar
• Khozin-Goldberg I, Cohen Z. The effect of phosphate starvation on the lipid and fatty acid composition of the fresh water eustigmatophyte Monodus subterraneus. Phytochem. 2006;67:696–701.
   PubMed Web of Science ®Google Scholar
• Iliev I, Petkov G, Lukavsky J, et al. The alga Trachydiscus minutus (Pseudostaurastrum minutum): growth and composition. Gen Appl Plant Physiol. 2010;36:222–231.
   Google Scholar
• Rezanka T, Petránková M, Cepák V, et al. Trachydiscus minutus, a new biotechnological source of eicosapentaenoic acid. Folia Microbiol (Praha). 2010;55:265–269.
   PubMed Web of Science ®Google Scholar
• Gigova L, Ivanova N, Gacheva G, et al. Response of trachydiscus minutus (xanthophyceae) to temperature and light(1). J Phycol. 2012; 48:85–93.
   PubMed Web of Science ®Google Scholar
• Krienitz L, Wirth M. The high content of polyunsaturated fatty acids in Nannochloropsis limnetica (Eustigmatophyceae) and its implication for food web interactions, freshwater aquaculture and biotechnology. Limnol - Ecol Manag Inland Waters. 2006;36:204–210.
   Web of Science ®Google Scholar
• Roncarati A, Meluzzi A, Acciarri S, et al. Fatty acid composition of different microalgae strains (Nannochloropsis sp., Nannochloropsis oculata (Droop) Hibberd, Nannochloropsis atomus Butcher and Isochrysis sp.) according to the culture phase and carbon dioxide concentration. J World Aquaculture Soc. 2004;35:401–411.
   Web of Science ®Google Scholar
• Cepák V, Přibyl P, Kohoutková J, et al. Optimization of cultivation conditions for fatty acid composition and EPA production in the eustigmatophycean microalga Trachydiscus minutus. J Appl Phycol. 2014;26:181–190.
   Web of Science ®Google Scholar
• Jo MJ, Hur SB. Growth and nutritional composition of Eustigmatophyceae Monodus subterraneus and Nannochloropsis oceanica in autotrophic and mixotrophic culture. Ocean Polar Res. 2015;37:61–71.
   Google Scholar
• Khozin-Goldberg I, Boussiba S. Concerns over the reporting of inconsistent data on fatty acid composition for microalgae of the genus Nannochloropsis (Eustigmatophyceae). J Appl Phycol. 2011;23:933–934.
   Web of Science ®Google Scholar
• Ma XN, Chen TP, Yang B, et al. Lipid production from Nannochloropsis. Mar Drugs. 2016;14:61.
   PubMed Web of Science ®Google Scholar
• Volkman JK, Brown MR, Dunstan GA, et al. The biochemical composition of marine microalgae from the class Eustigmatophyceae. J Phycol. 1993;29:69–78.
   Web of Science ®Google Scholar
• Volkman JK, Barrett SM, Blackburn SI, et al. Microalgal biomarkers: a review of recent research developments. Org Geochem. 1998;29:1163–1179.
   Web of Science ®Google Scholar
• Gelin F, Volkman JK, de Leeuw JW, et al. Mid-chain hydroxy long-chain fatty-acids in microalgae from genus Nannochloropsis. Phytochemistry. 1997;46:641–646.
   Google Scholar
• Sukenik A. Production of eicosapentaenoic acid by the marine eustigmatophyte Nannochloropsis. In: Cohen Z, editor. Chemicals from microalgae. London: CRC Press; 1999. p. 41–56.
   Google Scholar
• Boussiba S, Vonshak A, Cohen Z, et al. Lipid and biomass production by the halotolerant microalga Nannochloropsis salina. Biomass. 1987;12:37–47.
   Web of Science ®Google Scholar
• Chiu SY, Chien YK, Ming TT, et al. Lipid accumulation and CO2 utilization of Nannochloropsis oculata in response to CO2 aeration. Bioresour Technol. 2009;100:833–838.
   PubMed Web of Science ®Google Scholar
• Chi Y, Chen F, Takiguchi Y. Effect of nitrogen source on biomass and lipid production of a marine Microalga, Nannochloropsis oceanica IMET1. GSC. 2015;05:101–106.
   Google Scholar
• Zhang JJian, Wan LLin, Xia S, et al. Morphological and spectrometric analyses of lipids accumulation in a novel oleaginous microalga, Eustigmatos cf. polyphem (Eustigmatophyceae). Bioprocess Biosyst Eng. 2013;36:1125–1130.
   PubMed Web of Science ®Google Scholar
• Lam MK, Lee KT. Microalgae biofuels: a critical review of issues, problems and the way forward. Biotechnol Adv. 2012;30:673–690.
   PubMed Web of Science ®Google Scholar
• Doan TTY, Sivaloganathan B, Obbard JF. Screening of marine microalgae for biodiesel feedstock. Biomass Bioenergy. 2011;35:2534–2544.
   Web of Science ®Google Scholar
• Moazami N, Ashori A, Ranjbar R, et al. Large-scale biodiesel production using microalgae biomass of Nannochloropsis. Biomass Bioenergy. 2012;39:449–453.
   Web of Science ®Google Scholar
• Dinesh Kumar S, Santhanam P, Grace FLG. The techniques in microalgae bioremediation and algal co-product development. In: Santharaman P, Begum A, Pachiappan P, editors. Basic and applied phytoplankton biology. Singapore: Springer Nature; 2018. p. 191–210.
   Google Scholar
• Jinkerson RE, Radakovits R, Posewitz MC. Genomic insights from the oleaginous model alga Nannochloropsis gaditana. Bioengineered. 2013;4:37–43.
   PubMed Web of Science ®Google Scholar
• Radakovits R, Jinkerson RE, Fuerstenberg SI, et al. Draft genome sequence and genetic transformation of the oleaginous alga Nannochloropis gaditana. Nat Commun. 2012;3:686.
   PubMed Web of Science ®Google Scholar
• Vieler A, Wu G, Tsai C-H, et al. Genome, functional gene annotation, and nuclear transformation of the heterokont oleaginous alga Nannochloropsis oceanica CCMP1779. PLоS Genet. 2012;8:1–25.
   Web of Science ®Google Scholar
• Wang D, Ning K, Li J, et al. Nannochloropsis genomes reveal evolution of microalgal oleaginous traits. PLоS Genet. 2014;10:1–13.
   Web of Science ®Google Scholar
• Li N, Xu C, Li-Beisson Y, et al. Fatty acid and lipid transport in plant cells. Trends Plant Sci. 2016;21:145–158.
   PubMed Web of Science ®Google Scholar
• Poliner E, Panchy N, Newton L, et al. Transcriptional coordination of physiological responses in Nannochloropsis oceanica CCMP1779 under light/dark cycles. Plant J. 2015;83:1097–1113.
   PubMed Web of Science ®Google Scholar
• Alboresi A, Perin G, Vitulo N, et al. Light remodels lipid biosynthesis in Nannochloropsis gaditana by modulating carbon partitioning between organelles. Plant Physiol. 2016;171:2468–2482.
   PubMed Web of Science ®Google Scholar
• Kilian O, Benemann CSE, Niyogi KK, et al. High-efficiency homologous recombination in the oil-producing alga Nannochloropsis sp. Proc Natl Acad Sci USA. 2011;108:21265–21269.
   PubMed Web of Science ®Google Scholar
• Wang Q, Lu Y, Xin Y, et al. Genome editing of model oleaginous microalgae Nannochloropsis spp. By CRISPR/Cas9. Plant J. 2016;88:1071–1081.
   PubMed Web of Science ®Google Scholar
• Wei L, Xin Y, Wang Q, et al. RNAi-based targeted gene-knockdown in the model oleaginous microalgae Nannochloropsis oceanica. Plant J. 2017;89:1236–1250.
   PubMed Web of Science ®Google Scholar
• Tibbetts SM, Milley JE, Lall SP. Chemical composition and nutritional properties of freshwater and marine microalgal biomass cultured in photobioreactors. J Appl Phycol. 2015;27:1109–1119.
   Web of Science ®Google Scholar
• Stolz P, Obermayer B. Manufacturing microalgae for skin care. Cosmet Toilet. 2005;120:99–106.
   Google Scholar
• Pachiappan P, Santhanam P, Begum A, et al. 2018 An introduction to plankton. In: Santharaman P, Begum A, Pachiappan P, editors. Basic and applied phytoplankton biology. Singapore: Springer Nature; 2018. p. 1–24.
   Google Scholar
• Letsiou S, Kalliampakao K, Gardikis K, et al. Skin protective effects of Nannochloropsis gaditana extract on H2O2-stressed human dermal fibroblasts. Front Mar Sci. 2017;4:221.
   Web of Science ®Google Scholar
• Mourelle L, Gόmes CP, Martin MC, et al. Microalgae and Thermalism: Perspectives. J Jpn Soc Balneol Climatol Phys Med. 2014;5:537–538.
   Google Scholar
• Goh SH, Yusoff FM, Loh SP. A comparison of the antioxidant properties and total phenolic content in a diatom, Chaetoceros sp. and a green microalga, Nannochloropsis sp. J Agric Sci. 2010;2:123–130.
   Google Scholar
• Wolf BM, Niedzwiedzki DM, Magdaong NCM, et al. Characterization of a newly isolated freshwater Eustigmatophyte alga capable of utilizing far-red light as its sole light source. Photosyn Res. 2018;135:177–189.
   PubMed Web of Science ®Google Scholar
• Yurchenko T, Ševčíková T, Přibyl P, et al. A gene transfer event suggests a long-term partnership between eustigmatophyte algae and a novel lineage of endosymbiotic bacteria. ISME J. 2018;12:2163–2175.
   PubMed Web of Science ®Google Scholar
• Levine I, Fleurence J, editors. Microalgae in health and disease prevention. London UK: Elsevier; 2018.
   Google Scholar
• Karthikaichamy A, Deore P, Rai V, et al. Time for multiple extraction methods in proteomics? A comparison of three protein extraction methods in the eustigmatophyte alga Microchloropsis gaditana CCMP526. OMICS. 2017;21:678–683.
   PubMed Web of Science ®Google Scholar
• Nice EC. Challenges for omics technologies in the implementation of personalized medicine. Expert Rev Prec Medic Drug Develop. 2018;3:229–231.
   Web of Science ®Google Scholar
• Kagan ML, Matulka RA. Safety assessment of the microalgae Nannochloropsis oculata. Toxicol Rep. 2015;2:617–623.
   PubMed Web of Science ®Google Scholar
• Rai SV, Rajashekhar M. Effect of twelve species of marine phytoplankton on larval survival and development of the mosquito Culex quinquefasciatus. Int J Mar Sci. 2015;57:1–5.
   Google Scholar
• Balakrishnan S, Santhanam P, Manikam N, et al. A method of bio-efficacy potential of microalgae for the control of vector mosquitoes. In: Santharaman P, Begum A, Pachiappan P, editors. Basic and applied phytoplankton biology. Singapore: Springer Nature; 2018. p. 109–122.
   Google Scholar
• Matsumoto H, Shioji N, Hamasaki A, et al. Carbon dioxide fixation by microalgae photosynthesis using actual flue gas discharged from a boiler. Appl Biochem Biotechnol. 1995;51:681.
   Web of Science ®Google Scholar
• Matsumoto H, Shioji N, Hamasaki A, et al. Basic study on optimization of raceway-type algal cultivator. J Chem Eng Japan / JCEJ. 1996;29:541–543.
   Web of Science ®Google Scholar
• Biondi N, Bassi N, Chini Zittelli G, et al. Nannochloropsis sp. F&M-M24: oil production, effect of mixing on productivity and growth in an industrial wastewater. Environ Prog Sustainable Energy. 2013; 32:846–854.
   Web of Science ®Google Scholar
• McGinn PJ, Dickinson KE, Bhatti S, et al. Integration of microalgae cultivation with industrial waste remediation for biofuel and bioenergy production: opportunities and limitations. Photosyn Res. 2011;109:231–247.
   PubMed Web of Science ®Google Scholar
• Lu Y, Xu J. Phytohormones in microalgae: a new opportunity for microalgal biotechnology? Trends Plant Sci. 2015;20:273–282.
   Google Scholar