References
- Heyland J, Fu J, Blank LM, et al. Carbon metabolism limits recombinant protein production in Pichia pastoris. Biotechnol Bioeng. 2011;108:1942–1953.
- Hohenblum H, Borth N, Mattanovich D. Assessing viability and cell-associated product of recombinant protein producing Pichia pastoris with flow cytometry. J Biotechnol. 2003;102:281–290.
- Jorda J, Jouhten P, Camara E, et al. Metabolic flux profiling of recombinant protein secreting Pichia pastoris growing on glucose: methanol mixtures. Microb Cell Fact. 2012;8:11.
- Xie J, Yang R, Zhou Q, et al. Efficiencies of growth and angiostatin expression in cultures of Pichia pastoris fed with mixed carbon sources. Chem Biochem Eng Q. 2013;27:235–244.
- Jia L, Mpofu E, Tu T, et al. Transcriptional analysis for carbon metabolism and kinetic modeling for heterologous proteins productions by Pichia pastoris in induction process with methanol/sorbitol co-feeding. Process Biochem. 2017;59:159–166.
- Zhang P, Zhang WW, Zhou XS, et al. Catabolite repression of Aox in Pichia pastoris is dependent on hexose transporter PpHxt1 and pexophagy. Appl Environ Microbiol. 2010;76:6108–6118.
- Berrios J, Flores M-O, Díaz-Barrera A, et al. A comparative study of glycerol and sorbitol as co-substrates in methanol-induced cultures of Pichia pastoris: temperature effect and scale-up simulation. J Ind Microbiol Biotechnol. 2017;44:407–411.
- Farré JC, Manjithaya R, Mathewson RD, et al. PpAtg30 tags peroxisomes for turnover by selective autophagy. Dev Cell. 2008;14:365–376.
- Liu T, Zhang J. High-level expression and characterization of Aspergillus niger ATCC 1015 xylanase B in Komagataella phaffii. Appl Biol Chem. 2018;61:373–381.
- Green MR, Sambrook J. Molecular cloning: A laboratory manual. 4th ed. New York (NY): Cold Spring Harbor Laboratory Press; 2012.
- Zhang J, Liu T. Energy charge as an indicator of pexophagy in Pichia pastoris. Front Microbiol. 2017;8:963.
- Zhang JG, Wang XD, Zhang JN, et al. Oxygen vectors used for S-adenosylmethionine production in recombinant Pichia pastoris with sorbitol as supplemental carbon source. J Biosci Bioeng. 2008;105:335–340.
- Tuttle DL, Dunn W. Divergent modes of autophagy in the methylotrophic yeast Pichia pastoris. J Cell Sci. 1995;108:25–35.
- Looser V, Brühlmann B, Bumbak F, et al. Cultivation strategies to enhance productivity of Pichia pastoris: a review. Biotechnol Adv. 2015;98:1177–1193.
- Yang Z, Zhang Z. Engineering strategies for enhanced production of protein and bio-products in Pichia pastoris: a review. Biotechnol Adv. 2018;36:182–195.
- Singh S, Gras A, Fiez-Vandal C, et al. Large-scale functional expression of WT and truncated human adenosine A2A receptor in Pichia pastoris bioreactor cultures. Microb Cell Fact. 2008;7:28.
- Zhang WH, Potter KJH, Plantz BA, et al. Pichia pastoris fermentation with mixed-feeds of glycerol and methanol: growth kinetics and production improvement. J Ind Microbiol Biotechnol. 2003;30:210–215.
- Inan M, Meagher MM. Non-repressing carbon sources for alcohol oxidase (AOX1) promoter of Pichia pastoris. J Biosci Bioeng. 2001;92:585–589.
- Azadi S, Mahboubi A, Naghdi N, et al. Evaluation of sorbitol-methanol co-feeding strategy on production of recombinant human growth hormone in Pichia Pastoris. Iran J Pharm Res. 2017;16:1555–1564.
- Moreira LRS, Filho E. Insights into the mechanism of enzymatic hydrolysis of xylan. Appl Microbiol Biotechnol. 2016;100:5205–5214.
- Collins T, Gerday C, Feller G. Xylanases, xylanase families and extremophilic xylanases. FEMS Microbiol Rev. 2005;29:3–23.
- Zhang M, Cai G, Zheng E, et al. Transgenic pigs expressing beta-xylanase in the parotid gland improve nutrient utilization. Transgenic Res. 2019;22:189–198.
- Frisvad JC, Moller LLH, Larsen TO, et al. Safety of the fungal workhorses of industrial biotechnology: update on the mycotoxin and secondary metabolite potential of Aspergillus niger, Aspergillus oryzae, and Trichoderma reesei. Appl Microbiol Biotechnol. 2018;102:9481–9515.