4-Hydroxynonenal (HNE) and hepatic injury related to chronic oxidative stress

References

• Dianzani MU. 4-Hydroxynonenal from pathology to physiology. Mol Aspects Med. 2003;24(4–5):263–272.
   PubMedGoogle Scholar
• Chen ZH, Niki E. 4-hydroxynonenal (4-HNE) has been widely accepted as an inducer of oxidative stress. Is this the whole truth about it or can 4-HNE also exert protective effects? IUBMB Life. 2006;58(5–6):372–373.
   PubMed Web of Science ®Google Scholar
• Zhang H, Forman HJ. Signaling by 4-hydroxy-2-nonenal: exposure protocols, target selectivity and degradation. Arch Biochem Biophys. 2017;617:145–154.
   PubMed Web of Science ®Google Scholar
• Poli G, Biasi F, Leonarduzzi G. 4-Hydroxynonenal-protein adducts: a reliable biomarker of lipid oxidation in liver diseases. Mol Aspects Med. 2008;29(1–2):67–71.
   PubMed Web of Science ®Google Scholar
• Esterbauer H, Schaur RJ, Zollner H. Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes. Free Radic Biol Med. 1991;11(1):81–128.
   PubMed Web of Science ®Google Scholar
• Awasthi YC, Sharma R, Sharma A, et al. Self-regulatory role of 4-hydroxynonenal in signaling for stress-induced programmed cell death. Free Radic Biol Med. 2008;45(2):111–118.
   PubMed Web of Science ®Google Scholar
• Jacobs AT, Marnett LJ. Systems analysis of protein modification and cellular responses induced by electrophile stress. Acc Chem Res. 2010;43(5):673–683.
   PubMed Web of Science ®Google Scholar
• Pizzimenti S, Ciamporcero E, Daga M, et al. Interaction of aldehydes derived from lipid peroxidation and membrane proteins. Front Physiol. 2013;4:242
   PubMed Web of Science ®Google Scholar
• Milkovic L, Cipak Gasparovic A, Zarkovic N. Overview on major lipid peroxidation bioactive factor 4-hydroxynonenal as pluripotent growth-regulating factor. Free Radic Res. 2015;49(7):850–860.
   PubMed Web of Science ®Google Scholar
• Forman HJ, Fukuto JM, Miller T, et al. The chemistry of cell signaling by reactive oxygen and nitrogen species and 4-hydroxynonenal. Arch Biochem Biophys. 2008;477(2):183–195.
   PubMed Web of Science ®Google Scholar
• Uchida K. 4-hydroxy-2-nonenal: a product and mediator of oxidative stress. Prog Lipid Res. 2003;42(4):318–334.
   PubMed Web of Science ®Google Scholar
• Negre-Salvayre A, Vieira O, Escargueil-Blanc I, et al. Oxidized LDL and 4-hydroxynonenal modulate tyrosine kinase receptor activity. Mol Aspects Med. 2003;24(4–5):251–261.
   PubMedGoogle Scholar
• Raza H, John A. 4-hydroxynonenal induces mitochondrial oxidative stress, apoptosis and expression of glutathione S-transferase A4-4 and cytochrome P450 2E1 in PC12 cells. Toxicol Appl Pharmacol. 2006;216(2):309–318.
   PubMed Web of Science ®Google Scholar
• Roede JR, Jones DP. Reactive species and mitochondrial dysfunction: mechanistic significance of 4-hydroxynonenal. Environ Mol Mutagen. 2010;51(5):380–390.
   PubMed Web of Science ®Google Scholar
• Chapple SJ, Cheng X, Mann GE. Effects of 4-hydroxynonenal on vascular endothelial and smooth muscle cell redox signaling and function in health and disease. Redox Biol. 2013;1(1):319–331.
   PubMed Web of Science ®Google Scholar
• Arashiki N, Otsuka Y, Ito D, et al. The covalent modification of spectrin in red cell membranes by the lipid peroxidation product 4-hydroxy-2-nonenal. Biochem Biophys Res Commun. 2010;391(3):1543–1547.
   PubMed Web of Science ®Google Scholar
• Castro JP, Jung T, Grune T, et al. 4-Hydroxynonenal (HNE) modified proteins in metabolic diseases. Free Radic Biol Med. 2017;111:309–315.
   PubMed Web of Science ®Google Scholar
• Petersen DR, Doorn JA. Reactions of 4-hydroxynonenal with proteins and cellular targets. Free Radic Biol Med. 2004;37(7):937–945.
   PubMed Web of Science ®Google Scholar
• Ullery JC, Marnett LJ. Protein modification by oxidized phospholipids and hydrolytically released lipid electrophiles: investigating cellular responses. Biochim Biophys Acta. 2012;1818(10):2424–2435.
   PubMed Web of Science ®Google Scholar
• Dalleau S, Baradat M, Guéraud F, et al. Cell death and diseases related to oxidative stress: 4-hydroxynonenal (HNE) in the balance. Cell Death Differ. 2013;20(12):1615–1630.
   PubMed Web of Science ®Google Scholar
• Shoeb M, Ansari NH, Srivastava SK, et al. 4-hydroxynonenal in the pathogenesis and progression of human diseases. CMC. 2013;21(2):230–237.
   Web of Science ®Google Scholar
• Csala M, Kardon T, Legeza B, et al. On the role of 4-hydroxynonenal in health and disease. Biochim Biophys Acta. 2015;1852(5):826–838.
   PubMed Web of Science ®Google Scholar
• Di Domenico F, Tramutola A, Butterfield DA. Role of 4-hydroxy-2-nonenal (HNE) in the pathogenesis of alzheimer disease and other selected age-related neurodegenerative disorders. Free Radic Biol Med. 2017;111:253–261.
   PubMed Web of Science ®Google Scholar
• Moreau R, Nguyen BT, Doneanu CE, et al. Reversal by aminoguanidine of the age-related increase in glycoxidation and lipoxidation in the cardiovascular system of Fischer 344 rats. Biochem Pharmacol. 2005;69(1):29–40.
   PubMed Web of Science ®Google Scholar
• Wang L, Lv Y, Yao H, et al. Curcumin prevents the non-alcoholic fatty hepatitis via mitochondria protection and apoptosis reduction. Int J Clin Exp Pathol. 2015;8(9):11503–11509.
   PubMed Web of Science ®Google Scholar
• Barrera G, Pizzimenti S, Ciamporcero ES, et al. Role of 4-hydroxynonenal-protein adducts in human diseases. Antioxid Redox Signal. 2015;22(18):1681–1702.
   PubMed Web of Science ®Google Scholar
• Breitzig M, Bhimineni C, Lockey R, et al. 4-Hydroxy-2-nonenal: a critical target in oxidative stress? Am J Physiol Cell Physiol. 2016;311(4):C537–C543.
   PubMed Web of Science ®Google Scholar
• Pham RT, Gardner JL, Gallagher EP. Conjugation of 4-hydroxynonenal by largemouth bass (Micropterus salmoides) glutathione S-transferases. Mar Environ Res. 2002;54(3–5):291–295.
   PubMed Web of Science ®Google Scholar
• Singhal SS, Singh SP, Singhal P, Horne D, et al. Antioxidant role of glutathione S-transferases: 4-hydroxynonenal, a key molecule in stress-mediated signaling. Toxicol Appl Pharmacol. 2015;289(3):361–370.
   PubMed Web of Science ®Google Scholar
• Awasthi YC, Yang Y, Tiwari NK, et al. Regulation of 4hydroxynonenal-mediated signaling by glutathione S-transferases. Free Radic Biol Med. 2004;37(5):607–619.
   PubMed Web of Science ®Google Scholar
• Yang Y, Sharma R, Sharma A, et al. Lipid peroxidation and cell cycle signaling: 4-hydroxynonenal, a key molecule in stress mediated signaling. Acta Biochim Pol. 2003;50(2):319–336.
   PubMed Web of Science ®Google Scholar
• Brown JM, Kuhlman C, Terneus MV, et al. S-adenosyl-l-methionine protection of acetaminophen mediated oxidative stress and identification of hepatic 4-hydroxynonenal protein adducts by mass spectrometry. Toxicol Appl Pharmacol. 2014;281(2):174–184.
   PubMed Web of Science ®Google Scholar
• Sumida Y, Niki E, Naito Y, et al. Involvement of free radicals and oxidative stress in NAFLD/NASH. Free Radic Res. 2013;47(11):869–880.
   PubMed Web of Science ®Google Scholar
• Łuczaj W, Gęgotek A, Skrzydlewska E. Antioxidants and HNE in redox homeostasis. Free Radic Biol Med. 2017;111:87–101.
   PubMed Web of Science ®Google Scholar
• Yadav UCS, Ramana KV. Regulation of NF-κB-induced inflammatory signaling by lipid peroxidation-derived aldehydes. Oxid Med Cell Longev. 2013;2013:1.
   Google Scholar
• Timucin AC, Basaga H. Pro-apoptotic effects of lipid oxidation products: HNE at the crossroads of NF-κB pathway and anti-apoptotic Bcl-2. Free Radic Biol Med. 2017;111:209–218.
   PubMed Web of Science ®Google Scholar
• Nagakawa Y, Williams GM, Zheng Q, et al. Oxidative mitochondrial DNA damage and deletion in hepatocytes of rejecting liver allografts in rats: role of TNF-alpha. Hepatology 2005;42(1):208–215.
   PubMed Web of Science ®Google Scholar
• Sreeja S, Geetha R, Priyadarshini E, et al. Substitution of soy protein for casein prevents oxidative modification and inflammatory response induced in rats fed high fructose diet. ISRN Inflamm. 2014;2014:1.
   Google Scholar
• Tian Y, Ma J, Wang W, et al. Resveratrol supplement inhibited the NF-κB inflammation pathway through activating AMPKα-SIRT1 pathway in mice with fatty liver. Mol Cell Biochem. 2016;422(1–2):75–84.
   PubMed Web of Science ®Google Scholar
• Huang W, Glass CK. Nuclear receptors and inflammation control: molecular mechanisms and pathophysiological relevance. ATVB. 2010;30(8):1542–1549.
   Google Scholar
• Uchida K, Shiraishi M, Naito Y, et al. Activation of stress signaling pathways by the end product of lipid peroxidation 4-hydroxy-2-nonenal is a potential inducer of intracellular peroxide production. J Biol Chem. 1999;274(4):2234–2242.
   PubMed Web of Science ®Google Scholar
• Kensler TW, Wakabayashi N, Biswal S. Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway. Annu Rev Pharmacol Toxicol. 2007;47(1):89–116.
   PubMed Web of Science ®Google Scholar
• Baird L, Dinkova-Kostova AT. The cytoprotective role of the Keap1-Nrf2 pathway. Arch Toxicol. 2011;85(4):241–272.
   PubMed Web of Science ®Google Scholar
• Zhang H, Davies KJA, Forman HJ. Oxidative stress response and Nrf2 signaling in aging. Free Rad Biol Med. 2015;88(Pt B):314–336.
   PubMedGoogle Scholar
• Loboda A, Damulewicz M, Pyza E, et al. Role of Nrf2/HO-1 system in development, oxidative stress response and diseases: an evolutionarily conserved mechanism. Cell Mol Life Sci. 2016;73(17):3221–3247.
   PubMed Web of Science ®Google Scholar
• Bataille AM, Manautou J. Nrf2: a potential target for new therapeutics in liver disease. Clin Pharmacol Ther. 2012;92(3):340–348.
   PubMed Web of Science ®Google Scholar
• Cherrington N. Diversity in antioxidant response enzymes in progressive stages of human nonalcoholic fatty liver disease. Drug Metab Dispos. 2010;38:2293–2301.
   PubMed Web of Science ®Google Scholar
• Sharma RS, Harrison DJ, Kisielewski D, et al. Experimental nonalcoholic steatohepatitis and liver fibrosis are ameliorated by pharmacologic activation of Nrf2 (NF-E2 p45-related factor 2). Cell Mol Gastroenterol Hepatol. 2018;5(3):367–398.
   PubMed Web of Science ®Google Scholar
• Chaudhary P, Sharma R, Sharma A, et al. Mechanisms of 4-hydroxy-2-nonenal induced pro-and anti-apoptotic signaling. Biochemistry 2010;49(29):6263–6275.
   PubMed Web of Science ®Google Scholar
• Liu W, Porter NA, Schneider C, et al. Formation of 4-hydroxynonenal from cardiolipin oxidation: intramolecular peroxyl radical addition and decomposition. Free Rad Biol Med. 2011;50(1):166–178.
   PubMed Web of Science ®Google Scholar
• Paradies G, Paradies V, Ruggiero FM, et al. Oxidative stress, cardiolipin and mitochondrial dysfunction in nonalcoholic fatty liver disease. WJG. 2014;20(39):14205–14218.
   PubMed Web of Science ®Google Scholar
• Liu W, Kato M, Akhand AA, et al. 4-hydroxynonenal induces a cellular redox status-related activation of the caspase cascade for apoptotic cell death. J Cell Sci. 2000;113(Pt 4):635–641.
   PubMed Web of Science ®Google Scholar
• Ott M, Gogvadze V, Orrenius S, et al. Mitochondria, oxidative stress and cell death. Apoptosis 2007;12(5):913–922.
   PubMed Web of Science ®Google Scholar
• Le Bras M, Clément MV, Pervaiz S, et al. Reactive oxygen species and the mitochondrial signaling pathway of cell death. Histol Histopathol. 2005;20(1):205–219.
   PubMed Web of Science ®Google Scholar
• Valko M, Leibfritz D, Moncol J, et al. Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol. 2007;39(1):44–84.
   PubMed Web of Science ®Google Scholar
• Rector RS, Thyfault JP, Uptergrove GM, et al. Mitochondrial dysfunction precedes insulin resistance and hepatic steatosis and contributes to the natural history of non-alcoholic fatty liver disease in an obese rodent model. J Hepatol. 2010;52(5):727–736.
   PubMed Web of Science ®Google Scholar
• Sharma R, Sharma A, Dwivedi S, et al. 4-Hydroxynonenal self limits Fas-mediated DISC independent apoptosis by promoting export of Daxx from nucleus to cytosol and its binding to Fas. Biochemistry 2008;47(1):143–156.
   PubMed Web of Science ®Google Scholar
• Feldstein AE, Canbay A, Angulo P, et al. Hepatocyte apoptosis and fas expression are prominent features of human nonalcoholic steatohepatitis. Gastroenterology 2003;125(2):437–443.
   PubMed Web of Science ®Google Scholar
• Schwabe RF, Uchinami H, Qian T, et al. Differential requirement for c-Jun NH2-terminal kinase in TNFalpha- and Fas-mediated apoptosis in hepatocytes. FASEB J. 2004;18(6):720–722.
   PubMedGoogle Scholar
• Zelová H, Hošek J. TNF-α signalling and inflammation: interactions between old acquaintances. Inflamm Res. 2013;62(7):641–651.
   PubMed Web of Science ®Google Scholar
• Yin XM. Signal transduction mediated by bid, a pro-death Bcl-2 family proteins, connects the death receptor and mitochondria apoptosis pathways. Cell Res. 2000;10(3):161–167.
   PubMed Web of Science ®Google Scholar
• Shuh M, Bohorquez H, Loss GE, Jr, et al. Tumor necrosis factor-α: life and death of hepatocytes during liver ischemia/reperfusion injury. Ochsner J. 2013;13(1):119–130.
   PubMedGoogle Scholar
• Vieira HL, Belzacq AS, Haouzi D, et al. The adenine nucleotide translocator: a target of nitric oxide, peroxynitrite, and 4-hydroxynonenal. Oncogene 2001;20(32):4305–4316.
   PubMed Web of Science ®Google Scholar
• Jensen VS, Hvid H, Damgaard J, et al. Dietary fat stimulates development of NAFLD more potently than dietary fructose in sprague-dawley rats. Diabetol Metab Syndr. 2018;10(1):4.
   PubMedGoogle Scholar
• Katsiki N, Mikhailidis DP, Mantzoros CS. Non-alcoholic fatty liver disease and dyslipidemia: an update. Metabolism 2016;65(8):1109–1123.
   PubMed Web of Science ®Google Scholar
• Takahashi Y, Fukusato T. Histopathology of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis. WJG. 2014;20(42):15539–15548.
   PubMed Web of Science ®Google Scholar
• Spruss A, Bergheim I. Dietary fructose and intestinal barrier: potential risk factor in the pathogenesis of nonalcoholic fatty liver disease. J Nutr Biochem. 2009;20(9):657–662.
   PubMed Web of Science ®Google Scholar
• Musso G, Gambino R, De Michieli F, et al. Adiponectin gene polymorphisms modulate acute adiponectin response to dietary fat: possible pathogenetic role in NASH. Hepatology 2008;47(4):1167–1177.
   PubMed Web of Science ®Google Scholar
• Seki S, Kitada T, Yamada T, et al. In situ detection of lipid peroxidation and oxidative DNA damage in non-alcoholic fatty liver diseases. J Hepatol. 2002;37(1):56–62.
   PubMed Web of Science ®Google Scholar
• Rolo AP, Teodoro JS, Palmeira CM. Role of oxidative stress in the pathogenesis of nonalcoholic steatohepatitis. Free Rad Biol Med. 2012;52(1):59–69.
   PubMed Web of Science ®Google Scholar
• Serviddio G, Bellanti F, Vendemiale G. Free radical biology for medicine: learning from nonalcoholic fatty liver disease. Free Rad Biol Med. 2013;65:952–968.
   PubMed Web of Science ®Google Scholar
• Bellanti F, Villani R, Facciorusso A, et al. Lipid oxidation products in the pathogenesis of non-alcoholic steatohepatitis. Free Radic Biol Med. 2017;111:173–185.
   PubMed Web of Science ®Google Scholar
• Liu W, Baker SS, Baker RD, et al. Antioxidant mechanisms in nonalcoholic fatty liver disease. CDT. 2015;16(12):1301–1314.
   Google Scholar
• Czaja MJ. Induction and regulation of hepatocyte apoptosis by oxidative stress. Antioxid Redox Signal. 2002;4(5):759–767.
   PubMed Web of Science ®Google Scholar
• Malhi H, Gores GJ. Molecular mechanisms of lipotoxicity in nonalcoholic fatty liver disease. Semin Liver Dis. 2008;28(04):360–369.
   PubMedGoogle Scholar
• Schreuder TC, Verwer BJ, van Nieuwkerk CM, et al. Nonalcoholic fatty liver disease: an overview of current insights in pathogenesis, diagnosis and treatment. WJG. 2008;14(16):2474–2486.
   PubMed Web of Science ®Google Scholar
• Bekyarova G, Tzaneva M, Bratoeva K, et al. Heme- oxygenase-1 upregulated by S-adenosylmethionine potential protection against non-alcoholic fatty liver induced by high fructose diet. Farmatia 2017;65(2):262–267.
   Google Scholar
• Mantena SK, Vaughn DP, Andringa KK, et al. High fat diet induces dysregulation of hepatic oxygen gradients and mitochondrial function in vivo. Biochem J. 2009;417(1):183–193.
   PubMedGoogle Scholar
• Simões ICM, Fontes A, Pinton P, et al. Mitochondria in non-alcoholic fatty liver disease. Int J Biochem Cell Biol. 2018;95:93–99.
   PubMed Web of Science ®Google Scholar
• Sundaram SS, Halbower A, Pan Z, et al. Nocturnal hypoxia-induced oxidative stress promotes progression of pediatric non-alcoholic fatty liver disease. J Hepatol. 2016;65(3):560–569.
   PubMed Web of Science ®Google Scholar
• Videla LA, Rodrigo R, Araya J, et al. Oxidative stress and depletion of hepatic long-chain polyunsaturated fatty acids may contribute to nonalcoholic fatty liver disease. Free Rad Biol Med. 2004;37(9):1499–1507.
   PubMed Web of Science ®Google Scholar
• Yesilova Z, Yaman H, Oktenli C, et al. Systemic markers of lipid peroxidation and antioxidants in patients with nonalcoholic fatty liver disease. Am J Gastroenterol. 2005;100(4):850–855.
   PubMed Web of Science ®Google Scholar
• Baskol G, Baskol M, Kocer D. Oxidative stress and antioxidant defenses in serum of patients with non-alcoholic steatohepatitis. Clin Biochem. 2007;40(11):776–780.
   PubMed Web of Science ®Google Scholar
• Younossi ZM, Baranova A, Ziegler K, et al. A genomic and proteomic study of the spectrum of nonalcoholic fatty liver disease. Hepatology 2005;42(3):665–674.
   PubMed Web of Science ®Google Scholar
• Fu A, Shi X, Zhang H, et al. Mitotherapy for fatty liver by intravenous administration of exogenous mitochondria in male mice. Front Pharmacol. 2017;8:241
   PubMed Web of Science ®Google Scholar
• Caldwell SH, Swerdlow RH, Khan EM, et al. Mitochondrial abnormalities in non-alcoholic steatohepatitis. J Hepatol. 1999;31(3):430–434.
   PubMed Web of Science ®Google Scholar
• Li S, Takahara T, Fujino M, et al. Astaxanthin prevents ischemia-reperfusion injury of the steatotic liver in mice. PLoS ONE. 2017;12(11):e0187810.
   PubMed Web of Science ®Google Scholar
• Voehringer DW, Meyn RE. Redox aspects of Bcl-2 function. Antiox Redox Signal. 2000;2(3):537–550.
   PubMed Web of Science ®Google Scholar
• Martínez-Chantar ML, García-Trevijano ER, Latasa MU, et al. Importance of a deficiency in S-adenosyl-L-methionine synthesis in the pathogenesis of liver injury. Am J Clin Nutr. 2002;76(5):1177S–1182S.
   PubMed Web of Science ®Google Scholar
• Garcia-Ruiz C, Fernandez-Checa JC. Mitochondrial glutathione: hepatocellular survival-death switch. J Gastroenterol Hepatol. 2006;21:S3–S6.
   PubMed Web of Science ®Google Scholar
• Ribeiro PS, Cortez-Pinto H, Solá S, et al. Hepatocyte apoptosis, expression of death receptors, and activation of NF-kappaB in the liver of nonalcoholic and alcoholic steatohepatitis patients. Am J Gastroenterol. 2004;99(9):1708–1717.
   PubMed Web of Science ®Google Scholar
• Ding WX, Yin XM. Dissection of the multiple mechanisms of TNF-alpha-induced apoptosis in liver injury. J Cell Mol Med. 2004;8(4):445–454.
   PubMed Web of Science ®Google Scholar
• Singh R, Wang Y, Schattenberg JM, et al. Chronic oxidative stress sensitizes hepatocytes to death from 4-hydroxynonenal by JNK/c-Jun overactivation. Am J Physiol Gastrointest Liver Physiol. 2009;297(5):G907–G917.
   PubMed Web of Science ®Google Scholar
• Ibrahim MA, Kelleni M, Geddawy A. Nonalcoholic fatty liver disease: current and potential therapies. Life Sci. 2013;92(2):114–118.
   PubMed Web of Science ®Google Scholar
• Tsuruta F, Sunayama J, Mori Y, et al. JNK promotes bax translocation to mitochondria through phosphorylation of 14-3-3 proteins. EMBO J. 2004;23(8):1889–1899.
   PubMed Web of Science ®Google Scholar
• Malhi H, Bronk SF, Werneburg NW, et al. Free fatty acids induce JNK-dependent hepatocyte lipoapoptosis. J Biol Chem. 2006;281(17):12093–12101.
   PubMed Web of Science ®Google Scholar
• Jeong HS, Kim KH, Lee IS, et al. Ginkgolide A ameliorates non-alcoholic fatty liver diseases on high fat diet mice. Biomed Pharmacother. 2017;88:625–634.
   PubMed Web of Science ®Google Scholar