Tanshinone IIA inhibits proliferation and activates apoptosis in C4-1 cervical carcinoma cells in vitro

References

• Chen SJ. Drug-target networks for Tanshinone IIA identified by data mining. Chin J Nat Med. 2015;13(10):751–759.
   PubMed Web of Science ®Google Scholar
• Yang R, Liu A, Ma X. Sodium tanshinone IIA sulfonate protects cardiomyocytes against oxidative stress-mediated apoptosisi through inhibiting JNK activation. J Cardiovasc Pharmacol. 2008;51(4):396–401.
   PubMed Web of Science ®Google Scholar
• Liu X, Guo CY, Ma XJ, et al. Anti-inflammatory effects of tanshinone IIA on atherosclerostic vessels of ovariectomized ApoE mice are mediated by estrogen receptor activation and through the ERK signaling pathway. Cell Physiol Biochem. 2015; 35(5):1744–1755.
   PubMedGoogle Scholar
• Xu H, Hao YL, Xu LN, et al. Tanshinone sensitized the antitumor effects of irradiation on laryngeal cancer via JNK pathway. Cancer Med. 2018; 7(10):5187–5193.
   PubMed Web of Science ®Google Scholar
• Johnson SB, Park HS, Gross CP, et al. Complementary medicine, refusal of conventional cancer therapy, and survival among patients with curable cancers. JAMA Oncol 2018;4:1375–1381.
   Google Scholar
• Su CC. Tanshinone IIA inhibits human gastric carcinoma AGS cell growth by decresing BiP, TCTP, Mc11 and BclxL and increasing Bax and CHOP protein expression. Int J Mol Med. 2014;34(6):1661–1668.
   PubMed Web of Science ®Google Scholar
• Wang MZ, Feng RM, Wang S, et al. Clinical performance of Human Papillomavirus testing and visual inspection with acetic acid in primary, combination, and sequential cervical cancer screening in China. Sex Transm Dis. 2019;46(8):540–547.
   PubMed Web of Science ®Google Scholar
• He L, Gu K. Tanshinone IIA regulates colorectal cancer apoptosis via attenuation of Parkin‑mediated mitophagy by suppressing AMPK/Skp2 pathways. Mol Med Rep 2018; 18(2):1692–1703.
   PubMed Web of Science ®Google Scholar
• Qin J, Shi H, Xu Y, et al. Tanshinone IIA inhibits cervix carcinoma stem cells migration and invasion via inhibiting YAP transcriptional activity. Biomed Pharmaco Ther. 2018; 105:758–765.
   PubMed Web of Science ®Google Scholar
• Gullett NP, Ruhul Amin ARM, Bayraktar S, et al. Cancer prevention with natural compounds. Semin Oncol. 2010;37(3):258–281.
   PubMed Web of Science ®Google Scholar
• Kim DH, Shin EA, Kim B, et al. Reactive oxygen species-mediated phosphorylation of p38 signaling is critically involved in apoptotic effect of Tanshinone I in colon cancer cells. Phytother Res. 2018; 32(10):1975–1982.
   PubMed Web of Science ®Google Scholar
• Zhang Y, Li S, He H, et al. Influence of Tanshinone IIA on apoptosis of human esophageal carcinoma Eca-109 cells and its molecular mechanism. Thorac Cancer. 2017; 8(4):296–303.
   PubMed Web of Science ®Google Scholar
• Munagala R, Aqil F, Jeyabalan J, et al. Tanshinone IIA inhibits viral oncogene expression leading to apoptosis and inhibition of cervical cancer. Cancer Lett. 2015; 356(2):536–546.
   PubMed Web of Science ®Google Scholar
• Li MC, Liu W, Shao WR. Progress of study on anti-human cervical papilloma virus infection with Chinese and Western medicine. Zhongguo Zhong Xi Yi Jie He Za Zhi 2007; 27(6):573–575. (Abstract in English).
   PubMedGoogle Scholar
• Cao YF, Wang SF, Li X, et al. The anticancer mechanism investigation of Tanshinone IIA by pharmacological clustering in protein network. BMC Syst Biol. 2018; 12(1):90.
   PubMedGoogle Scholar
• Zhang RW, Liu ZG, Li MC, et al. In vitro inhibition of invasion and metastasis in colon cancer cells by TanIIA. Genet Mol Res 2016; 15(3): 1–4. gmr.153039008.
   Web of Science ®Google Scholar
• Chien SY, Kuo SJ, Chen YL, et al. Tanshinone IIA inhibits human hepatocellular carcinoma J5 cell growth by increasing Bax and caspase 3 and decreasing CD31 expression in vivo. Mol Med Rep 2012;5(1):282–286.
   PubMed Web of Science ®Google Scholar
• Zhuang S, Cheng TH, Shih NL, et al. Tanshinone IIA induces heme oxygenase 1 expression and inhibits cyclic strain-induced interleukin 8 expression in vascular endothelial cells. Am J Chin Med. 2016; 44(02):377–388.
   PubMedGoogle Scholar
• Alzhrani RM, Alhadidi Q, Bachu RD, et al. Tanshinone IIA inhibits VEGF secretion and HIF-1α expression in cultured human retinal pigment epithelial cells under hypoxia. Curr Eye Res. 2017; 42(12):1667–1673.
   PubMed Web of Science ®Google Scholar
• Eskander RN, Tewari KS. Chemotherapy in the treatment of metastatic, persistent, and recurrent cervical cancer. Curr Opin Obstet Gynecol. 2014;26(4):314–321.
   PubMed Web of Science ®Google Scholar
• Dong W, Zhang Y, Chen X, et al. High-dose tanshinone IIA suppresses migration and proliferation while promoting apoptosis of astrocytoma cells via Notch-1 pathway. Neurochem Res. 2018;43(9):1855–1861. 208;
   PubMed Web of Science ®Google Scholar
• Chen C, Wang HJ, Liu FR, et al. Preparation and antitumor effects of tanshinone IIA loaded albumin nanoparticles. Zhongguo Zhong Yao Za Zhi 2017; 42(4):696–701. (Abstract in English).
   PubMedGoogle Scholar
• Yun SM, Jeong SJ, Kim JH, et al. Activation of c-JunN-terminal kinase mediates tanshinone IIA-induced apoptosis in KBM-5 chronic myeloid leukemia cells. Bio Pharm Bull 2013; 36(2):208–214.
   PubMed Web of Science ®Google Scholar
• Zaker A, Asili J, Abrishamchi P, et al. Cytotoxic and apoptotic effects of root extract and tanshinones isolated from Perovskiaabrotanoides Kar. Iran J Basic Med Sci. 2017; 20(12):1377–1384.
   PubMed Web of Science ®Google Scholar
• Cui ZT, Liu JP, Wei WL. The effects of tanshinone IIA on hypoxia/reoxygenation-induced myocardial microvascular endothelial cell apoptosis in rats via the JAK2/STAT3 signaling pathway. Biomed Pharmacother. 2016; 83:1116–1126.
   PubMed Web of Science ®Google Scholar
• Ren X, Wang C, Xie B, et al. Tanshinone IIA induced cell death via miR30b-p53-PTPN11/SHP2 signaling pathway in human hepatocellular carcinoma cells. Eur J Pharmacol.2017; 796:233–241.
   PubMed Web of Science ®Google Scholar
• Zhu YQ, Wang BY, Wu F, et al. Influence of Tanshinone IIA on the apoptosis of human esophageal Ec-109 cells. Nat Prod Commun. 2016; 11(1):17–19.
   PubMed Web of Science ®Google Scholar
• Hao W, Chen L, Wu LF, et al. Tanshinone IIA exerts an antinociceptive effect in rats with cancer-induced bone pain. Pain Physician. 2016; 19(7):465–476.
   PubMed Web of Science ®Google Scholar
• Wang N, Chang Y, Chen L, et al. Tanshinone IIA protects against chronic intermittent hypoxia-induced myocardial injury via activating the endothelin 1 pathway. Biomed Pharmacother. 2017; 95:1013–1020.
   PubMed Web of Science ®Google Scholar
• Huang J, Lin H, Hong Y. In vitro anti-tumor activity of the tanshinone IIA against SKOV3 cells. Nat Prod Res. 2016; 30(16):1844–1846.
   PubMed Web of Science ®Google Scholar
• Park YK, Obiang-Obounou BW, Lee J, et al. Anti-adipogenic effects on 3T3-L1 Cells and zebrafish by tanshinone IIA. Int. J. Mol. Sci. 2017;18(2065): ijms18102065/1-24.
   Google Scholar
• Schneider-Gädicke A, Schwarz E. Different human cervical carcinoma cell lines show similar transcription patterns of human papillomavirus type 18 early genes. EMBO J. 1986; 5(9):2285–2292.
   PubMed Web of Science ®Google Scholar
• Feng FB, Qiu HY. Neuroprotective effect of tanshinone IIA against neuropathic pain in diabetic rats through the Nrf2/ARE and NF-κB signaling pathways. Kaohsiung J Med Sci. 2018; 34(8):428–437.
   PubMed Web of Science ®Google Scholar
• Chao A, Lin CT, Lai CH. Updates in systemic treatment for metastatic cervical cancer. Curr treat Options in Oncol. 2014;15(1):1–13.
   PubMed Web of Science ®Google Scholar