A doxycycline-inducible C17.2 neural stem cell-based combination of differentiation and suicide gene therapy for an in vitro tumorigenic C6 glioma model

References

• Ostrom QT, Gittleman H, Truitt G, et al. CBTRUS statistical report: primary brain and other central nervous system tumors diagnosed in the united states in 2011-2015. Neuro-Oncology. 2018;20(suppl_4):iv1–iv86.
   PubMed Web of Science ®Google Scholar
• Louis DN. Molecular pathology of malignant gliomas. Annu Rev Pathol. 2006;1:97–117.
   PubMed Web of Science ®Google Scholar
• Culver KW, Ram Z, Wallbridge S, et al. In vivo gene transfer with retroviral vector-producer cells for treatment of experimental brain tumors. Science. 1992;256(5063):1550–1552.
   PubMed Web of Science ®Google Scholar
• Portnow J, Synold TW, Badie B, et al. Neural stem cell-based anticancer gene therapy: a first-in-human study in recurrent high-grade glioma patients. Clin Cancer Res. 2017;23(12):2951–2960.
   PubMed Web of Science ®Google Scholar
• Aboody KS, Brown A, Rainov NG, et al. Neural stem cells display extensive tropism for pathology in adult brain: evidence from intracranial gliomas. Proc Natl Acad Sci USA. 2000;97(23):12846–12851.
   PubMed Web of Science ®Google Scholar
• Stuckey DW, Shah K. Stem cell-based therapies for cancer treatment: separating hope from hype. Nat Rev Cancer. 2014;14(10):683–691.
   PubMed Web of Science ®Google Scholar
• Duarte S, Carle G, Faneca H, et al. Suicide gene therapy in cancer: where do we stand now? Cancer Lett. 2012;324(2):160–170.
   PubMed Web of Science ®Google Scholar
• Colombo MP, Trinchieri G. Interleukin-12 in anti-tumor immunity and immunotherapy. Cytokine Growth Factor Rev. 2002;13(2):155–168.
   PubMed Web of Science ®Google Scholar
• Kim SS, Harford JB, Moghe M, et al. A tumor-targeting nanomedicine carrying the p53 gene crosses the blood-brain barrier and enhances anti-PD-1 immunotherapy in mouse models of glioblastoma. Int J Cancer. 2019;145(9):2535–2546.
   PubMed Web of Science ®Google Scholar
• Geletneky K, Hajda J, Angelova AL, et al. Oncolytic H-1 parvovirus shows safety and signs of immunogenic activity in a first phase I/IIa glioblastoma trial. Mol Ther. 2017;25(12):2620–2634.
   PubMed Web of Science ®Google Scholar
• Mooney R, Hammad M, Batalla‐Covello J, et al. Concise review: neural stem Cell-Mediated Targeted Cancer Therapies. Stem Cells Transl Med. 2018;7(10):740–747.
   PubMed Web of Science ®Google Scholar
• Mullen CA, Kilstrup M, Blaese RM. Transfer of the bacterial gene for cytosine deaminase to mammalian cells confers lethal sensitivity to 5-fluorocytosine: a negative selection system. Proc Natl Acad Sci USA. 1992;89(1):33–37.
   PubMed Web of Science ®Google Scholar
• Beltinger C, Fulda S, Kammertoens T, et al. Herpes simplex virus thymidine kinase/ganciclovir-induced apoptosis involves ligand-independent death receptor aggregation and activation of caspases. Proc Natl Acad Sci USA. 1999;96(15):8699–8704.
   PubMed Web of Science ®Google Scholar
• Lee AS, Tang C, Rao MS, et al. Tumorigenicity as a clinical hurdle for pluripotent stem cell therapies. Nat Med. 2013;19(8):998–1004.
   PubMed Web of Science ®Google Scholar
• Park J, Kim CG, Shim JK, et al. Effect of combined anti-PD-1 and temozolomide therapy in glioblastoma. Oncoimmunology. 2019;8(1):e1525243.
   PubMed Web of Science ®Google Scholar
• Cammarata FP, Torrisi F, Forte GI, et al. Proton therapy and Src family kinase inhibitor combined treatments on U87 human glioblastoma multiforme cell line. IJMS. 2019;20(19):4745.
   Web of Science ®Google Scholar
• Polyak K, Hahn WC. Roots and stems: stem cells in cancer. Nat Med. 2006;12(3):296–300.
   PubMed Web of Science ®Google Scholar
• Piccirillo SG, Reynolds BA, Zanetti N, et al. Bone morphogenetic proteins inhibit the tumorigenic potential of human brain tumour-initiating cells. Nature. 2006;444(7120):761–765.
   PubMed Web of Science ®Google Scholar
• Basile MS, Mazzon E, Krajnovic T, et al. Anticancer and differentiation properties of the nitric oxide derivative of lopinavir in human glioblastoma cells. Molecules. 2018;23(10):2463. Sep 26
   Web of Science ®Google Scholar
• Fang KM, Yang CS, Lin TC, et al. Induced interleukin-33 expression enhances the tumorigenic activity of rat glioma cells. Neuro-oncology. 2014;16(4):552–566.
   PubMed Web of Science ®Google Scholar
• Nakase T, Naus CC. Gap junctions and neurological disorders of the central nervous system. Biochim Biophys Acta. 2004;1662(1-2):149–158.
   PubMed Web of Science ®Google Scholar
• Asklund T, Appelskog IB, Ammerpohl O, et al. Gap junction-mediated bystander effect in primary cultures of human malignant gliomas with recombinant expression of the HSVtk gene. Exp Cell Res. 2003;284(2):185–195.
   PubMed Web of Science ®Google Scholar
• Li S, Tokuyama T, Yamamoto J, et al. Bystander effect-mediated gene therapy of gliomas using genetically engineered neural stem cells. Cancer Gene Ther. 2005;12(7):600–607.
   PubMed Web of Science ®Google Scholar
• Schichor C, Birnbaum T, Etminan N, et al. Vascular endothelial growth factor A contributes to glioma-induced migration of human marrow stromal cells (hMSC). Exp Neurol. 2006;199(2):301–310.
   PubMed Web of Science ®Google Scholar
• Jurvansuu J, Zhao Y, Leung DS, et al. Transmembrane protein 18 enhances the tropism of neural stem cells for glioma cells. Cancer Res. 2008;68(12):4614–4622.
   PubMed Web of Science ®Google Scholar
• Shaimardanova AA, Kitaeva KV, Abdrakhmanova II, et al. Production and application of multicistronic constructs for various human disease therapies. Pharmaceutics. 2019;11(11):580. Nov 6
   PubMed Web of Science ®Google Scholar
• Sharma P, Yan F, Doronina VA, et al. 2A peptides provide distinct solutions to driving stop-carry on translational recoding. Nucleic Acids Res. 2012;40(7):3143–3151.
   PubMed Web of Science ®Google Scholar
• Yaghoubi SS, Campbell DO, Radu CG, et al. Positron emission tomography reporter genes and reporter probes: gene and cell therapy applications. Theranostics. 2012;2(4):374–391.
   PubMed Web of Science ®Google Scholar
• Kumar NM, Gilula NB. The gap junction communication channel. Cell. 1996;84(3):381–388.
   PubMed Web of Science ®Google Scholar
• Spray DC, Hanstein R, Lopez-Quintero SV, et al. Gap junctions and bystander effects: good Samaritans and executioners. Wiley Interdiscip Rev Membr Transp Signal. 2013;2(1):1–15.
   PubMedGoogle Scholar
• Papaccio F, Paino F, Regad T, et al. Concise review: cancer cells, cancer stem cells, and mesenchymal stem cells: influence in cancer development. Stem Cells Transl Med. 2017;6(12):2115–2125.
   PubMed Web of Science ®Google Scholar
• Kreso A, Dick JE. Evolution of the cancer stem cell model. Cell Stem Cell. 2014;14(3):275–291.
   PubMed Web of Science ®Google Scholar