1,000
Views
0
CrossRef citations to date
0
Altmetric
Articles

Expression of senescence markers in human PDL stem cells after long-term cultivation in vitro

, , , , & ORCID Icon
Pages 1024-1030 | Received 29 Mar 2021, Accepted 17 Jun 2021, Published online: 09 Jul 2021

References

  • Shay JW, Wright WE. Hayflick, his limit, and cellular ageing. Nat Rev Mol Cell Biol. 2000;1(1):72–76.
  • Hayflick L. The limited in vitro lifetime of human diploid cell strains. Exp Cell Res. 1965;37:614–636.
  • Turinetto V, Vitale E, Giachino C. Senescence in human mesenchymal stem cells: functional changes and implications in stem cell-based therapy. IJMS. 2016;17(7):1164.
  • Sharpe PT. Dental mesenchymal stem cells. Development 2016;143(13):2273–2280.
  • Park JY, Jeon SH, Choung PH. Efficacy of periodontal stem cell transplantation in the treatment of advanced periodontitis. Cell Transplant 2011;20(2):271–285.
  • Mihaylova Z, Tsikandelova R, Sanimirov P, et al. Role of PDGF-BB in proliferation, differentiation and maintaining stem cell properties of PDL cells in vitro. Arch Oral Biol. 2018;85:1–9.
  • Madeira A, da Silva CL, dos Santos F, et al. Human mesenchymal stem cell expression program upon extended ex-vivo cultivation, as revealed by 2-DE-based quantitative proteomics. PLoS One 2012;7(8):e43523.
  • Feng XM, Xing J, Feng GJ, et al. p16(INK4A) mediates age-related changes in mesenchymal stem cells derived from human dental pulp through the DNA damage and stress response. Mech Ageing Dev. 2014;141-142:46–55.
  • Horibe H, Murakami M, Iohara K, et al. Isolation of a stable subpopulation of mobilized dental pulp stem cells (MDPSCs) with high proliferation, migration, and regeneration potential is independent of age. PLoS One 2014;9(5):e98553.
  • Zhang J, An Y, Gao LN, et al. The effect of aging on the pluripotential capacity and regenerative potential of human periodontal ligament stem cells. Biomaterials 2012;33(29):6974–6986.
  • Oh J, Lee YD, Wagers AJ. Stem cell aging: mechanisms, regulators and therapeutic opportunities. Nat Med. 2014;20(8):870–880.
  • Rinaldi S, Maioli M, Santaniello S, et al. Regenerative treatment using a radioelectric asymmetric conveyor as a novel tool in antiaging medicine: an in vitro beta-galactosidase study. Clin Interv Aging 2012;7:191.
  • Danisovic L, Oravcova L, Krajciova L, et al. Effect of long-term culture on the biological and morphological characteristics of human adipose tissue-derived stem cells. J Physiol Pharmacol. 2017;68(1):149–158.
  • Geng YQ, Guan JT, Xu XH, et al. Senescence-associated beta-galactosidase activity expression in aging hippocampal neurons. Biochem Biophys Res Commun. 2010;396(4):866–869.
  • Yang NC, Hu ML . The limitations and validities of senescence associated-beta-galactosidase activity as an aging marker for human foreskin fibroblast Hs68 cells. Exp Gerontol. 2005;40(10):813–819.
  • Lee BY, Han JA, Im JS, et al . Senescence-associated beta-galactosidase is lysosomal beta-galactosidase. Aging Cell 2006;5(2):187–195.
  • Severino J, Allen RG, Balin S, et al. Is beta-galactosidase staining a marker of senescence in vitro and in vivo?Exp Cell Res. 2000;257(1):162–171.
  • Wagner W, Horn P, Castoldi M, et al. Replicative senescence of mesenchymal stem cells: a continuous and organized process. PLoS One 2008;3(5):e2213.
  • Suchánek J, Visek B, Soukup T, et al. Stem cells from human exfoliated deciduous teeth-isolation, long-term cultivation and phenotypical analysis. Acta Med (Hradec Kralove) 2010;53(2):93–99.
  • Yang H, Gao LN, An Y, et al. Comparison of mesenchymal stem cells derived from gingival tissue and periodontal ligament in different incubation conditions. Biomaterials 2013;34(29):7033–7047.
  • Straka M, Kupcová I, Varga I, et al. Effect of long-term cultivation on morphological and biological characteristics of human periodontal ligament stem cells. Neuroendocrinol Lett. 2016;37(5):361–367.
  • Mihaylova Z, Stanimirov P, Miteva M, et al. Periodontal ligament stem cell properties after long-term in vitro cultivation. Problems Dent Med. 2019;1(45):44–50.