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Research Article

Biotransformation of ginsenosides by glycoside hydrolase from an endophytic fungus of Panax ginseng

ORCID Icon, , , &
Article: 2362852 | Received 14 Jan 2024, Accepted 29 May 2024, Published online: 05 Jun 2024

References

  • Cui L, Wu S, Zhao C, et al. Microbial conversion of major ginsenosides in ginseng total saponins by Platycodon grandiflorum endophytes. J Ginseng Res. 2016;40(4):1–10. doi: 10.1016/j.jgr.2015.11.004.
  • Park S, Lim H, Park K, et al. Fungal endophytes from three cultivars of Panax ginseng Meyer cultivated in Korea. J Ginseng Res. 2012a;36(1):107–113. doi: 10.5142/jgr.2012.36.1.107.
  • Park Y, Kim Y, Mishra RC, et al. Fungal endophytes inhabiting mountain-cultivated ginseng (Panax ginseng Meyer): Diversity and biocontrol activity against ginseng pathogens. Sci Rep. 2017;7(1):16221. doi: 10.1038/s41598-017-16181-z.
  • Wu H, Yang HY, You XL, et al. Diversity of endophytic fungi from roots of Panax ginseng and their saponin yield capacities. Springerplus. 2013;2(1):107. doi: 10.1186/2193-1801-2-107.
  • Chu LL, Bae H. Bacterial endophytes from ginseng and their biotechnological application. J Ginseng Res. 2022;46(1):1–10. doi: 10.1016/j.jgr.2021.04.004.
  • Wang P, Tang C, Liu Y, et al. Biotransformation of high concentrations of ginsenoside substrate into compound K by β-glycosidase from Sulfolobus solfataricus. Genes (Basel). 2023;14(4):897. doi: 10.3390/genes14040897.
  • Ancheeva E, Daletos G, Proksch P. Bioactive secondary metabolites from endophytic fungi. Curr Med Chem. 2020;27(11):1836–1854. doi: 10.2174/0929867326666190916144709.
  • Becker K, Stadler M. Recent progress in biodiversity research on the Xylariales and their secondary metabolism. J Antibiot (Tokyo). 2021;74(1):1–23. doi: 10.1038/s41429-020-00376-0.
  • Fu Y. Biotransformation of ginsenoside Rb1 to Gyp-XVII and minor ginsenoside Rg3 by endophytic bacterium Flavobacterium sp. GE 32 isolated from Panax ginseng. Lett Appl Microbiol. 2019;68(2):134–141. doi: 10.1111/lam.13090.
  • Fu Y, Yin ZH, Wu LP, et al. Biotransformation of ginsenoside Rb1 to ginsenoside C-K by endophytic fungus Arthrinium sp. GE 17-18 isolated from Panax ginseng. Lett Appl Microbiol. 2016;63(3):196–201. doi: 10.1111/lam.12606.
  • Kim M, Upadhyaya J, Yoon M, et al. Highly regioselective biotransformation of ginsenoside Rb2 into compound Y and compound K by β-glycosidase purified from Armillaria mellea mycelia. J Ginseng Res. 2018;42(4):504–511. doi: 10.1016/j.jgr.2017.07.001.
  • An D-S, Cui C-H, Lee H-G, et al. Identification and characterization of a novel Terrabacter ginsenosidimutans sp. nov. β-glucosidase that transforms ginsenoside Rb1 into the rare gypenosides XVII and LXXV. Appl Environ Microbiol. 2010;76(17):5827–5836. doi: 10.1128/AEM.00106-10.
  • Wang L, Liu Q, Sung B, et al. Bioconversion of ginsenosides Rb1, Rb2, Rc and Rd by novel β-glucosidase hydrolyzing outer 3-O glycoside from Sphingomonassp. 2F2: cloning, expression, and enzyme characterization. J Biotechnol. 2011;156(2):125–133. doi: 10.1016/j.jbiotec.2011.07.024.
  • Zheng Y, Miao C, Chen H, et al. Endophytic fungi harbored in Panax notoginseng: diversity and potential as biological control agents against host plant pathogens of root-rot disease. J Ginseng Res. 2017;41(3):353–360. doi: 10.1016/j.jgr.2016.07.005.
  • Xu L, Han T, Wu J, et al. Comparative research of chemical constituents, antifungal and antitumor properties of ether extracts of Panax ginseng and its endophytic fungus. Phytomedicine. 2009;16(6-7):609–616. doi: 10.1016/j.phymed.2009.03.014.
  • Park YH, Lee SG, Ahn DJ, et al. Diversity of fungal endophytes in various tissues of Panax ginseng Meyer cultivated in Korea. J Ginseng Res. 2012b;36(2):211–217.
  • Yan H, Jin H, Fu Y, et al. Production of rare ginsenosides Rg3 and Rh2 by endophytic bacteria from Panax ginseng. J Agric Food Chem. 2019;67(31):8493–8499. doi: 10.1021/acs.jafc.9b03159.
  • Cao L, Wu H, Zhang H, et al. Highly efficient production of diverse rare ginsenosides using combinatorial biotechnology. Biotechnol Bioeng. 2020;117(6):1615–1627. doi: 10.1002/bit.27325.
  • Chopra P, Chhillar H, Kim YJ, et al. Phytochemistry of ginsenosides: recent advancements and emerging roles. Crit Rev Food Sci Nutr. 2023;63(5):613–640. doi: 10.1080/10408398.2021.1952159.
  • Tran TNA, Son J, Awais M, et al. β-Glucosidase and Its application in bioconversion of ginsenosides in Panax ginseng. Bioengineering. 2023;10(4):484. doi: 10.3390/bioengineering10040484.
  • Fu C, Shen W, Li W, et al. Engineered β-glycosidase from hyperthermophilic sulfolobus solfataricus with improved Rd-hydrolyzing activity for ginsenoside compound K production. Appl Biochem Biotechnol. 2023. doi: 10.1007/s12010-023-04745-x.
  • Wang R, Pu Z, Janke JJ, et al. Engineered glycosidase for significantly improved production of naturally rare vina-ginsenoside R7. J Agric Food Chem. 2023;71(8):3852–3861. doi: 10.1021/acs.jafc.2c09115.
  • Wang Z, Wang L, Pan Y, et al. Research advances on endophytic fungi and their bioactive metabolites. Bioprocess Biosyst Eng. 2023;46(2):165–170. doi: 10.1007/s00449-022-02840-7.
  • Zhu H, Zhang R, Huang Z, et al. Progress in the conversion of ginsenoside Rb1 into minor ginsenosides using β-glucosidases. Foods. 2023;12(2):397. doi: 10.3390/foods12020397.
  • Hong H, Cui C, Kim J, et al. Enzymatic biotransformation of ginsenoside rb1 and gypenoside xvii into ginsenosides Rd and F2 by recombinant β-glucosidase from Flavobacterium johnsoniae. J Ginseng Res. 2012;36(4):418–424. doi: 10.5142/jgr.2012.36.4.418.
  • Cui CH, Kim JK, Kim SC, et al. Characterization of a ginsenoside-transforming beta-glucosidase from Paenibacillus mucilaginosus and its application for enhanced production of minor ginsenoside F(2). PLoS One. 2014;9(1):e85727. doi: 10.1371/journal.pone.0085727.
  • Kim SJ, Lee CM, Kim MY, et al. Screening and characterization of an enzyme with beta-glucosidase activity from environmental DNA. J Microbiol Biotechnol. 2007;17(6):905–912.
  • Renchinkhand G, Magsar U, Bae HC, et al. Identification of β-glucosidase activity of Lentilactobacillus buchneri URN103L and its potential to convert ginsenoside Rb1 from Panax ginseng. Foods. 2022;11(4):529. doi: 10.3390/foods11040529.