Publication Cover
Amyloid
The Journal of Protein Folding Disorders
Volume 12, 2005 - Issue 1
267
Views
73
CrossRef citations to date
0
Altmetric
Original Article

Multiple ligand binding sites on Aβ(1–40) fibrils

Pages 5-14 | Published online: 06 Jul 2009

References

  • Klunk WE, Jacob RF, Mason RP. Quantifying amyloid by Congo Red spectral shift assay. Methods Enzymol 1999;309:285–305.
  • Naiki H, Higuchi K, Hosokawa M, Takeda T. Fluorometric determination of amyloid fibrils in vitro using the fluorescent dye, Thioflavin T. Anal Biochem 1989;177:244–249.
  • LeVine H, III. Thioflavine T interaction with synthetic Alzheimer’s disease beta-amyloid peptides: Detection of amyloid aggregation in solution. Protein Sci 1993;2:404–410.
  • LeVine H, III. Quantification of beta-sheet amyloid fibril structures with Thioflavin T. Methods Enzymol 1999;309:274–284.
  • Zhuang ZP, Kung MP, Hou C, Skovronsky DM, Gur TL, Plossl K, Trojanowski JQ, Lee VM, Kung HF. Radioiodinated styrylbenzenes and thioflavins as probes for amyloid aggregates. J Med Chem 2001;44:1905–1914.
  • Kung HF, Kung MP, Zhuang ZP, Hou C, Lee CW, Plossl K, Zhuang B, Skovronsky DM, Lee VM, Trojanowski JQ. Iodinated tracers for imaging amyloid plaques in the brain. Mol Imaging Biol 2003;5:418–426.
  • Skovronsky DM, Zhang B, Kung MP, Kung HF, Trojanowski JQ, Lee VM. In vivo detection of amyloid plaques in a mouse model of Alzheimer’s disease. Proc Natl Acad Sci USA 2000; 97:7609–7614.
  • Lee HJ, Zhang Y, Zhu C, Duff K, Pardridge WM. Imaging brain amyloid of Alzheimer’s disease in vivo in transgenic mice with an Abeta peptide radiopharmaceutical. J Cerebral Blood Flow & Metab 2002;22:223–231.
  • Bacskai BJ, Hickey GA, Skoch J, Kajdasz ST, Wang Y, Huang GF, Mathis CA, Klunk WE, Hyman BT. Four-dimensional multiphoton imaging of brain entry, amyloid binding, and clearance of an amyloid-{beta}ligand in transgenic mice. Proc Natl Acad Sci USA 2003;100:12462–12467.
  • Okamura N, Suemoto T, Shimadzu H, Suzuki M, Shiomitsu T, Akatsu H, Yamamoto T, Staufenbiel M, Yanai K, Arai H, et al. Styrylbenzoxazole derivatives for in vivo imaging of amyloid plaques in the brain. J Neurosci 2004;24:2535–2541.
  • Kung MP, Hou C, Zhuang ZP, Cross AJ, Maier DL, Kung HF. Characterization of IMPY as a potential imaging agent for beta-amyloid plaques in double transgenic PSAPP mice. Eur J Nucl Med Mol Imaging 2004;epub DOI 10.1007/ S00259-004-1487-z.
  • Klunk WE, Engler H, Nordberg A, Wang Y, Blomqvist G, Holt DP, Bergstrom M, Savitcheva I, Huang GF, Estrada S, et al. Imaging brain amyloid in Alzheimer’s disease with Pittsburgh Compound-B. Ann Neurol 2004;55:306–319.
  • Shoghi-Jadid K, Small GW, Agdeppa ED, Kepe V, Ercoli LM, Siddarth P, Read S, Satyamurthy N, Petric A, Huang SC, Barrio JR. Localization of neurofibrillary tangles and beta-amyloid plaques in the brains of living patients with Alzheimer disease. Am J Geriatr Psychiatry 2002;10:24–35.
  • Tycko R. Insights into the amyloid folding problem from solid-state NMR. Biochemistry 2003;42:3151–3159.
  • Tycko R. Progress towards a molecular-level structural understanding of amyloid fibrils. Curr Opin Struct Biol 2004;14:96–103.
  • Williams AD, Portelius E, Kheterpal I, Guo JT, Cook KD, Xu Y, Wetzel R. Mapping abeta amyloid fibril secondary structure using scanning proline mutagenesis. J Mol Biol 2004;335:833–842.
  • LeVine H, III. Thioflavine T interaction with amyloid b-sheet structures. Amyloid: Int J Exp Clin Invest 1995;2:1–6.
  • Mathis CA, Wang Y, Holt DP, Huang GF, Debnath ML, Klunk WE. Synthesis and evaluation of 11C-labeled 6- substituted 2-arylbenzothiazoles as amyloid imaging agents. J Med Chem 2003;46:2740–2754.
  • Klunk WE, Wang Y, Huang GF, Debnath ML, Holt DP, Mathis CA. Uncharged Thioflavin-T derivatives bind to amyloid-beta protein with high affinity and readily enter the brain. Life Sci 2001;69:1471–1484.
  • Mathis CA, Wang Y, Klunk WE. Imaging beta-amyloid plaques and neurofibrillary tangles in the aging human brain. Curr Pharm Des 2004;10:1469–1492.
  • Mathis CA, Bacskai BJ, Kajdasz ST, McLellan ME, Frosch MP, Hyman BT, Holt DP, Wang Y, Huang GF, Debnath ML, Klunk WE. A lipophilic Thioflavin-T derivative for positron emission tomography (PET) imaging of amyloid in brain. Bioorganic & Medicinal Chemistry Letters 2002;12:295–298.
  • Agdeppa ED, Kepe V, Liu J, Small GW, Huang SC, Petric A, Satyamurthy N, Barrio JR. 2-dialkylamino-6-acylmalononitrile substituted naphthalenes (DDNP analogs): Novel diagnostic and therapeutic tools in Alzheimer’s disease. Mol Imaging Biol 2003a;5:404–417.
  • Agdeppa ED, Kepe V, Petri A, Satyamurthy N, Liu J, Huang SC, Small GW, Cole GM, Barrio JR. In vitro detection of (S)-naproxen and ibuprofen binding to plaques in the Alzheimer’s brain using the positron emission tomography molecular imaging probe 2-(1-[6-[(2-[(18)F]fluoroethyl) (methyl)amino]-2-naphthyl]ethylidene)malononitrile. Neuroscience 2003;117:723–730.
  • Huang CY. Determination of binding stoichiometry by the continuous variation method: The Job plot. Methods Enzymol 1982;87:509–525.
  • LeVine H, III. Stopped-flow kinetics reveal multiple phases of Thioflavin T binding to Alzheimer beta (1-40) amyloid fibrils. Arch Biochem Biophys 1997;342:306–316.
  • Stine WB, Jr., Snyder SW, Ladror US, Wade WS, Miller MF, Perun TJ, Holzman TF, Krafft GA. The nanometer-scale structure of amyloid-beta visualized by atomic force microscopy. J Protein Chem 1996;15:193–203.
  • Wang Z, Zhou C, Wang C, Wan L, Fang X, Bai C. AFM and STM study of beta-amyloid aggregation on graphite. Ultra-microscopy 2003;97:73–79.
  • Wood SJ, Maleeff B, Hart T, Wetzel R. Physical, morphological and functional differences between pH 5.8 and 7.4 aggregates of the Alzheimer’s amyloid peptide Abeta. J Mol Biol 1996;256:870–877.
  • Antzutkin ON, Leapman RD, Balbach JJ, Tycko R. Supramolecular structural constraints on Alzheimer’s beta-amyloid fibrils from electron microscopy and solid-state nuclear magnetic resonance. Biochemistry 2002;41:15436–15450.
  • Roterman I, No KT, Piekarska B, Kaszuba J, Pawlicki R, Rybarska J, Konieczny L. Bis azo dyes-studies on the mechanism of complex formation with IgG modulated by heating or antigen binding. J Physiol Pharmacol 1993;44:213–232.
  • Sunde M, Serpell LC, Bartlam M, Fraser PE, Pepys MB, Blake CC. Common core structure of amyloid fibrils by synchrotron x-ray diffraction. J Mol Biol 1997;273:729–739.
  • Serpell LC, Sunde M, Benson MD, Tennent GA, Pepys MB, Fraser PE. The protofilament substructure of amyloid fibrils. J Mol Biol 2000;300:1033–1039.
  • Blake CC, Serpell LC, Sunde M, Sandgren O, Lundgren E. A molecular model of the amyloid fibril. Ciba Found Symp 1996;199:40–46.
  • Lu K, Jacob J, Thiyagarajan P, Conticello VP, Lynn DG. Exploiting amyloid fibril lamination for nanotube self-assembly. J Am Chem Soc 2003;125:6391–6393.
  • Roterman I, KrUl M, Nowak M, Konieczny L, Rybarska J, Stopa B, Piekarska B, Zemanek G. Why Congo Red binding is specific for amyloid proteins-model studies and a computer analysis approach. Med Sci Monit 2001;7:771–784.
  • Carter DB, Chou KC. A model for structure-dependent binding of Congo Red to Alzheimer beta-amyloid fibrils. Neurobiol Aging 1998;19:37–40.
  • Brange J, Dodson GG, Edwards DJ, Holden PH, Whittingham JL. A model of insulin fibrils derived from the x-ray crystal structure of a monomeric insulin (despentapeptide insulin). Proteins 1997;27:507–516.
  • Walker LC, Bian F, Callahan MJ, Lipinski WJ, Durham RA, LeVine H. Modeling Alzheimer’s disease and other proteopathies in vivo: Is seeding the key? Amino Acids 2002;23:87–93.
  • Kane MD, Lipinski WJ, Callahan MJ, Bian F, Durham RA, Schwarz RD, Roher AE, Walker LC. Evidence for seeding of beta-amyloid by intracerebral infusion of Alzheimer brain extracts in beta-amyloid precursor protein-transgenic mice. J Neurosci 2000;20:3606–3611.
  • Walker LC, Callahan MJ, Bian F, Durham RA, Roher AE, Lipinski WJ. Exogenous induction of cerebral beta-amyloidosis in betaAPP-transgenic mice. Peptides 2002;23:1241–1247.
  • Meyer-Luehmann M, Stalder M, Herzig MC, Kaeser SA, Kohler E, Pfeifer M, Boncristiano S, Mathews PM, Mercken M, Abramowski D, et al. Extracellular amyloid formation and associated pathology in neural grafts. Nat Neurosci 2003; 6:370–377.
  • Harper JD, Wong SS, Lieber CM, Lansbury PT. Observation of metastable Abeta amyloid protofibrils by atomic force microscopy. Chem Biol 1997;4:119–125.
  • Citron BA, Suo Z, SantaCruz K, Davies PJ, Qin F, Festoff BW. Protein crosslinking, tissue transglutaminase, alternative splicing and neurodegeneration. Neurochem Int 2002;40:69–78.
  • Norlund MA, Lee JM, Zainelli GM, Muma NA. Elevated transglutaminase-induced bonds in PHF tau in Alzheimer’s disease. Brain Res 1999;851:154–163.
  • Reddy VP, Obrenovich ME, Atwood CS, Perry G, Smith MA. Involvement of Maillard reactions in Alzheimer disease. Neurotox Res 2002;4:191–209.
  • Serot JM, Bene MC, Faure GC. Choroid plexus, ageing of the brain, and Alzheimer’s disease. Front Biosci 2003;8:S515–S521.
  • Huang X, Moir RD, Tanzi RE, Bush AI, Rogers JT. Redox- active metals, oxidative stress, and Alzheimer’s disease pathology. Ann N Y Acad Sci 2004;1012:153–163.
  • Head E, Garzon-Rodriguez W, Johnson JK, Lott IT, Cotman CW, Glabe C. Oxidation of Abeta and plaque biogenesis in Alzheimer’s disease and Down syndrome. Neurobiol Dis 2001;8:792–806.
  • O’Nuallain B, Williams AD, Westermark P, Wetzel R. Seeding specificity in amyloid growth induced by hetero- logous fibrils. J Biol Chem 2004;279:17490–17499.
  • Tanaka M, Chien P, Naber N, Cooke R, Weissman JS. Conformational variations in an infectious protein determine prion strain differences. Nature 2004;428:323–328.
  • Peretz D, Scott MR, Groth D, Williamson RA, Burton DR, Cohen FE, Prusiner SB. Strain-specified relative conforma- tional stability of the scrapie prion protein. Protein Sci 2001;10:854–863.
  • Chien P, DePace AH, Collins SR, Weissman JS. Generation of prion transmission barriers by mutational control of amyloid conformations. Nature 2003;424:948–951.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.