Publication Cover
Redox Report
Communications in Free Radical Research
Volume 1, 1995 - Issue 5
2
Views
3
CrossRef citations to date
0
Altmetric
Original Articles

Protective effects of coenzyme Q10 and α-tocopherol against free radical-mediated liver cell injury

, &
Pages 343-347 | Accepted 16 May 1995, Published online: 13 Jul 2016

References

  • Mellors A, Tappel A L. The inhibition of mitochondrial peroxidation by ubiquinone and ubiquinol. J Biol Chem 1966; 241: 4353–4356.
  • Beyer R E. The participation of coenzyme Q in free radical production and antioxidation. Free Radic Biol Med 1990; 8: 545–565.
  • Frei B, Kim M C, Ames B N. Ubiquinol-10 is an effective lipid-soluble antioxidant at physiological concentrations. Proc Natl Acad Sci U S A 1990; 87: 4879–4883.
  • Yamamoto Y, Komuro E, Niki E. Antioxidant activity of ubiquinol in solution and phosphatidylcholine liposome. J Nutr Sci Vitaminol (Tokyo) 1990; 36: 505–511.
  • Stocker R, Bowry V W, Frei B. Ubiquinol-10 protects human low density lipoprotein more efficiently against lipid peroxidation than does α-tocopherol. Proc Natl Acad Sci U S A 1991; 88: 1646–1650.
  • Kagan V E, Serbinova E A, Koynova G M et al. Antioxidant action of ubiquinol homologues with different isoprenoid chain length in biomembranes. Free Radic Biol Med 1990; 9: 117–126.
  • Matsura T, Yamada K, Kawasaki T. Difference in antioxidant activity between reduced coenzyme Q9 and reduced coenzyme Q10 in the cell: studies with isolated rat and guinea pig hepatocytes treated with a water-soluble radical initiator. Biochim Biophys Acta 1992; 1123: 309–315.
  • Matsura T, Yamada K, Kawasaki T. Antioxidant role of cellular reduced coenzyme Q homologs and α-tocopherol in free radical-induced injury of hepatocytes isolated from rats fed diets with different vitamin E contents. Biochim Biophys Acta 1992; 1127: 277–283.
  • Amimoto T, Matsura T, Koyama S, Nakanishi T, Yamada K, Kajiyama G. Acetaminophen-induced hepatic injury in mice: the role of lipid peroxidation and effects of pretreatment with coenzyme Q10 and α-tocopherol. Free Radic Biol Med 1995; 19: 169–176.
  • Marubayashi S, Dohi K, Yamada K, Kawasaki T. Changes in the levels of endogenous coenzyme Q homologs, α-tocopherol and glutathione in rat liver after hepatic ischemia and reperfusion, and the effect of pretreatment with CoQ10 Biochim Biophys Acta 1984; 797: 1–9.
  • Packer L, Landvik S. Vitamin E: introduction to biochemistry and health benefits. Ann N Y Acad Sci 1989; 570: 1–6.
  • Niki E. Antioxidants in relation to lipid peroxidation. Chem Phys Lipids 1987; 44: 227–253.
  • Seglen P O. Preparation of isolated rat liver cells. Methods Cell Biol 1976; 13: 29–83.
  • Yamamoto M, Shima T, Uozumi T, Sogabe T, Yamada K, Kawasaki T. A possible role of lipid peroxidation in cellular damages caused by cerebral ischemia and the protective effect of α-tocopherol administration. Stroke 1983; 14: 977–982.
  • Lowry O H, Rosebrough N J, Farr A L, Randall R J. Protein measurement with the folin phenol reagent. J Biol Chem 1951; 193: 265–275.
  • Yamamoto Y, Niki E, Kamiya Y, Shimasaki H. Oxidation of lipids 7. Oxidation of phosphatidylcholines in homogeneous solution and in water dispersion. Biochim Biophys Acta 1984; 795: 332–340.
  • Ingold K U, Bowry V W, Stocker R, Walling C. Autoxidation of lipids and antioxidation by α-tocopherol and ubiquinol in homogeneous solution and in aqueous dispersions of lipids: unrecognized consequences of lipid particle size as exemplified by oxidation of human low density lipoprotein. Proc Natl Acad Sci U S A 1993; 90: 45–49.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.